PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15197732-5	2004	The transcription of the hexose transporter and related genes was strongly influenced by the presence of glucose; HXT1, HXT2 and HXT3 were greatly activated by glucose and HXT5, HXT7 and AGT1 were significantly repressed by glucose.	Glucose	105-112	alpha-glucoside permease	Saccharomyces cerevisiae S288C	187-191
15128531-4	2004	We also found that Agt1p-mediated trehalose transport and the hydrolysis of the disaccharide by the cytosolic neutral trehalase Nth1p are coupled and represent a second, independent pathway, although there are several constraints on this alternative route.	Trehalose	34-43	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-24
15128531-4	2004	We also found that Agt1p-mediated trehalose transport and the hydrolysis of the disaccharide by the cytosolic neutral trehalase Nth1p are coupled and represent a second, independent pathway, although there are several constraints on this alternative route.	Disaccharides	80-92	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-24
15128531-6	2004	Second, Agt1p rapidly lost activity during growth on trehalose, by a mechanism similar to the sugar-induced inactivation of the maltose permease.	Trehalose	53-62	alpha-glucoside permease	Saccharomyces cerevisiae S288C	8-13
15128531-6	2004	Second, Agt1p rapidly lost activity during growth on trehalose, by a mechanism similar to the sugar-induced inactivation of the maltose permease.	Sugars	94-99	alpha-glucoside permease	Saccharomyces cerevisiae S288C	8-13
16965366-3	2006	While the presence of maltose in the medium did not improve maltotriose fermentation, enhanced and constitutive expression of the AGT1 permease not only increased the uptake of maltotriose, but allowed efficient maltotriose fermentation by this strain.	maltotriose	177-188	alpha-glucoside permease	Saccharomyces cerevisiae S288C	130-134
16965366-3	2006	While the presence of maltose in the medium did not improve maltotriose fermentation, enhanced and constitutive expression of the AGT1 permease not only increased the uptake of maltotriose, but allowed efficient maltotriose fermentation by this strain.	maltotriose	177-188	alpha-glucoside permease	Saccharomyces cerevisiae S288C	130-134
16965366-5	2006	CONCLUSIONS: Over expression of the AGT1 permease and magnesium supplementation improved maltotriose fermentation by an industrial yeast strain that respired but did not ferment this sugar.	maltotriose	89-100	alpha-glucoside permease	Saccharomyces cerevisiae S288C	36-40
16965366-5	2006	CONCLUSIONS: Over expression of the AGT1 permease and magnesium supplementation improved maltotriose fermentation by an industrial yeast strain that respired but did not ferment this sugar.	Sugars	183-188	alpha-glucoside permease	Saccharomyces cerevisiae S288C	36-40
16965366-6	2006	SIGNIFICANCE AND IMPACT OF THE STUDY: This work contributes to the elucidation of the roles of the AGT1 permease and nutrients in the fermentation of all sugars present in starch hydrolysates, a highly desirable trait for several industrial yeasts.	Sugars	154-160	alpha-glucoside permease	Saccharomyces cerevisiae S288C	99-103
16965366-6	2006	SIGNIFICANCE AND IMPACT OF THE STUDY: This work contributes to the elucidation of the roles of the AGT1 permease and nutrients in the fermentation of all sugars present in starch hydrolysates, a highly desirable trait for several industrial yeasts.	Starch	172-178	alpha-glucoside permease	Saccharomyces cerevisiae S288C	99-103
15197732-5	2004	The transcription of the hexose transporter and related genes was strongly influenced by the presence of glucose; HXT1, HXT2 and HXT3 were greatly activated by glucose and HXT5, HXT7 and AGT1 were significantly repressed by glucose.	Glucose	160-167	alpha-glucoside permease	Saccharomyces cerevisiae S288C	187-191
15197732-5	2004	The transcription of the hexose transporter and related genes was strongly influenced by the presence of glucose; HXT1, HXT2 and HXT3 were greatly activated by glucose and HXT5, HXT7 and AGT1 were significantly repressed by glucose.	Glucose	160-167	alpha-glucoside permease	Saccharomyces cerevisiae S288C	187-191
11438190-5	2001	pNPalphaG uptake is mediated by the AGT1 alpha-glucoside permease, which has a high affinity (Km=3 mM) for this chromogenic substrate.	4-nitrophenyl alpha-glucoside	0-9	alpha-glucoside permease	Saccharomyces cerevisiae S288C	36-40
12406721-6	2002	By complementing this strain with permeases encoded by MAL31, MAL61, and AGT1, it was possible to measure their specific transport kinetics by using maltotriose and maltose.	maltotriose	149-160	alpha-glucoside permease	Saccharomyces cerevisiae S288C	73-77
12406721-6	2002	By complementing this strain with permeases encoded by MAL31, MAL61, and AGT1, it was possible to measure their specific transport kinetics by using maltotriose and maltose.	Maltose	165-172	alpha-glucoside permease	Saccharomyces cerevisiae S288C	73-77
12406721-8	2002	Maltotriose utilization from the permease encoded by AGT1 was regulated by the same genetic mechanisms as those involving the maltose transcriptional activator.	maltotriose	0-11	alpha-glucoside permease	Saccharomyces cerevisiae S288C	53-57
12406721-8	2002	Maltotriose utilization from the permease encoded by AGT1 was regulated by the same genetic mechanisms as those involving the maltose transcriptional activator.	Maltose	126-133	alpha-glucoside permease	Saccharomyces cerevisiae S288C	53-57
12406721-9	2002	Competition studies carried out with two industrial strains, one not containing any homologue of AGT1, showed that maltose uptake and maltotriose uptake were competitive and that maltose was the preferred substrate.	Maltose	115-122	alpha-glucoside permease	Saccharomyces cerevisiae S288C	97-101
12406721-9	2002	Competition studies carried out with two industrial strains, one not containing any homologue of AGT1, showed that maltose uptake and maltotriose uptake were competitive and that maltose was the preferred substrate.	maltotriose	134-145	alpha-glucoside permease	Saccharomyces cerevisiae S288C	97-101
12406721-9	2002	Competition studies carried out with two industrial strains, one not containing any homologue of AGT1, showed that maltose uptake and maltotriose uptake were competitive and that maltose was the preferred substrate.	Maltose	179-186	alpha-glucoside permease	Saccharomyces cerevisiae S288C	97-101
15741738-6	2004	Deletion of the AGT1 gene, which encodes a high-affinity sucrose-H(+) symporter, rendered cells incapable of sucrose fermentation.	Sucrose	57-64	alpha-glucoside permease	Saccharomyces cerevisiae S288C	16-20
15741738-6	2004	Deletion of the AGT1 gene, which encodes a high-affinity sucrose-H(+) symporter, rendered cells incapable of sucrose fermentation.	Sucrose	109-116	alpha-glucoside permease	Saccharomyces cerevisiae S288C	16-20
15741738-7	2004	Since sucrose is not an inducer of the permease, expression of the AGT1 must be constitutive in order to allow growth of the hxt-null strain on sucrose.	Sucrose	6-13	alpha-glucoside permease	Saccharomyces cerevisiae S288C	67-71
15741738-7	2004	Since sucrose is not an inducer of the permease, expression of the AGT1 must be constitutive in order to allow growth of the hxt-null strain on sucrose.	Sucrose	144-151	alpha-glucoside permease	Saccharomyces cerevisiae S288C	67-71
12702465-5	2001	On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for maltose and maltotriose, and a very low affinity (K(m) approximately 35 mM) for alpha-methylglucoside.	Trehalose	123-132	alpha-glucoside permease	Saccharomyces cerevisiae S288C	63-67
12702465-5	2001	On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for maltose and maltotriose, and a very low affinity (K(m) approximately 35 mM) for alpha-methylglucoside.	Maltose	180-187	alpha-glucoside permease	Saccharomyces cerevisiae S288C	63-67
12702465-5	2001	On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for maltose and maltotriose, and a very low affinity (K(m) approximately 35 mM) for alpha-methylglucoside.	maltotriose	192-203	alpha-glucoside permease	Saccharomyces cerevisiae S288C	63-67
12702465-5	2001	On the other hand, the alpha-glucoside permease encoded by the AGT1 gene had a high affinity (K(m) approximately 7 mM) for trehalose, a low affinity (K(m) approximately 18 mM) for maltose and maltotriose, and a very low affinity (K(m) approximately 35 mM) for alpha-methylglucoside.	methylglucoside	260-281	alpha-glucoside permease	Saccharomyces cerevisiae S288C	63-67
16232731-2	2000	The MAL2T permease has a low affinity (K(m) = 120 +/-20 mM) for sucrose, while the alpha-glucoside transporter encoded by the AGT1 gene is a high affinity sucrose-H+ symporter (K(m) = 7.9+/-0.8 mM) that increases the specific growth rate of cells growing on sucrose.	Sucrose	64-71	alpha-glucoside permease	Saccharomyces cerevisiae S288C	126-130
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Glycogen	201-209	alpha-glucoside permease	Saccharomyces cerevisiae S288C	104-108
10957961-5	2000	The high-affinity trehalose-H+ symporter encoded by the AGT1 gene is required for growth on trehalose.	Trehalose	18-27	alpha-glucoside permease	Saccharomyces cerevisiae S288C	56-60
10957961-5	2000	The high-affinity trehalose-H+ symporter encoded by the AGT1 gene is required for growth on trehalose.	Trehalose	92-101	alpha-glucoside permease	Saccharomyces cerevisiae S288C	56-60
11055939-6	2000	The genes represented by HAC1, PRY1, and ICT1 have been reported to be associated with cell stress, and AGT1 and GAC1 have been reported to be involved in the uptake of trehalose and the production of glycogen, respectively.	Trehalose	169-178	alpha-glucoside permease	Saccharomyces cerevisiae S288C	104-108
10791714-3	2000	The uptake of trehalose was shown to be mediated by the alpha-glucoside transporter encoded by AGT1, the expression of which is linked to the presence of a functional MAL locus.	Trehalose	14-23	alpha-glucoside permease	Saccharomyces cerevisiae S288C	95-99
10791714-5	2000	However, small amounts of disaccharide were still detected in a agt1 tps1 double mutant when the medium was supplemented with 10 g trehalose l(-1), indicating the existence of a non-concentrative low-affinity sugar transporter.	Disaccharides	26-38	alpha-glucoside permease	Saccharomyces cerevisiae S288C	64-73
10791714-5	2000	However, small amounts of disaccharide were still detected in a agt1 tps1 double mutant when the medium was supplemented with 10 g trehalose l(-1), indicating the existence of a non-concentrative low-affinity sugar transporter.	Trehalose	131-140	alpha-glucoside permease	Saccharomyces cerevisiae S288C	64-73
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	Maltose	92-99	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
16232731-2	2000	The MAL2T permease has a low affinity (K(m) = 120 +/-20 mM) for sucrose, while the alpha-glucoside transporter encoded by the AGT1 gene is a high affinity sucrose-H+ symporter (K(m) = 7.9+/-0.8 mM) that increases the specific growth rate of cells growing on sucrose.	Sucrose	155-162	alpha-glucoside permease	Saccharomyces cerevisiae S288C	126-130
16232731-2	2000	The MAL2T permease has a low affinity (K(m) = 120 +/-20 mM) for sucrose, while the alpha-glucoside transporter encoded by the AGT1 gene is a high affinity sucrose-H+ symporter (K(m) = 7.9+/-0.8 mM) that increases the specific growth rate of cells growing on sucrose.	Sucrose	155-162	alpha-glucoside permease	Saccharomyces cerevisiae S288C	126-130
10368160-0	1999	AGT1, encoding an alpha-glucoside transporter involved in uptake and intracellular accumulation of trehalose in Saccharomyces cerevisiae.	Trehalose	99-108	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-4
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	Trehalose	101-110	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
9925567-11	1999	Sequences corresponding to the AGT1 gene, which encodes a transporter of several alpha-glucosides, including maltose and maltotriose, were detected in all but one of the yeast strains.	alpha-glucosides	81-97	alpha-glucoside permease	Saccharomyces cerevisiae S288C	31-35
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	maltotriose	112-123	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
9925567-11	1999	Sequences corresponding to the AGT1 gene, which encodes a transporter of several alpha-glucosides, including maltose and maltotriose, were detected in all but one of the yeast strains.	Maltose	109-116	alpha-glucoside permease	Saccharomyces cerevisiae S288C	31-35
1999393-3	1991	The high-affinity maltose transporter is maltose inducible and is encoded by the MAL11 (and/or MAL61) gene of the MAL1 (and/or MAL6) locus.	Maltose	18-25	alpha-glucoside permease	Saccharomyces cerevisiae S288C	81-86
9925567-11	1999	Sequences corresponding to the AGT1 gene, which encodes a transporter of several alpha-glucosides, including maltose and maltotriose, were detected in all but one of the yeast strains.	maltotriose	121-132	alpha-glucoside permease	Saccharomyces cerevisiae S288C	31-35
9468339-6	1998	Our results also suggest that the recently characterized AGT1 gene of S. cerevisiae may encode the high-affinity trehalose-H+ symporter.	Trehalose	113-122	alpha-glucoside permease	Saccharomyces cerevisiae S288C	57-61
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Maltose	39-46	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Maltose	108-115	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	turanose	120-128	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	alpha-glucosides	163-179	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	alpha-glucosides	163-179	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Isomaltose	216-226	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Isomaltose	216-226	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	methylglucoside	228-249	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	methylglucoside	228-249	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	maltotriose	251-262	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	maltotriose	251-262	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	isomaltulose	264-274	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	isomaltulose	264-274	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Trehalose	276-285	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	Trehalose	276-285	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	melezitose	290-300	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-18
8594329-5	1995	Like Mal61p, Agt1p is a high-affinity, maltose/proton symporter, but Mal61p is capable of transporting only maltose and turanose, while Agt1p transports these two alpha-glucosides as well as several others including isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose.	melezitose	290-300	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-141
8594329-6	1995	AGT1 expression is maltose inducible and induction is mediated by the Mal-activator.	Maltose	19-26	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-4
8594329-7	1995	The sequence of the upstream region of AGT1 is identical to that of the maltose-inducible MAL61 gene over a 469 bp region containing the UASMAL but the 315 bp sequence immediately upstream of AGT1 shows no significant homology to the sequence immediately upstream of MAL61.	Maltose	72-79	alpha-glucoside permease	Saccharomyces cerevisiae S288C	39-43
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	methylglucoside	125-146	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	melezitose	148-158	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
9919658-1	1999	The AGT1 permease is a alpha-glucoside-H+ symporter responsible for the active transport of maltose, trehalose, maltotriose, alpha-methylglucoside, melezitose and sucrose.	Sucrose	163-170	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
1999393-3	1991	The high-affinity maltose transporter is maltose inducible and is encoded by the MAL11 (and/or MAL61) gene of the MAL1 (and/or MAL6) locus.	Maltose	41-48	alpha-glucoside permease	Saccharomyces cerevisiae S288C	81-86
33279674-1	2021	Proton coupled transport of alpha-glucosides via Mal11 into Saccharomyces cerevisiae costs one ATP per imported molecule.	alpha-glucosides	28-44	alpha-glucoside permease	Saccharomyces cerevisiae S288C	49-54
35448589-3	2022	In this study, we applied an evolutionary engineering strategy to alter the substrate specificity of the proton-coupled disaccharide transporter Mal11 in Saccharomyces cerevisiae, which has affinity for sucrose, maltose and glucose.	Sucrose	203-210	alpha-glucoside permease	Saccharomyces cerevisiae S288C	145-150
35448589-3	2022	In this study, we applied an evolutionary engineering strategy to alter the substrate specificity of the proton-coupled disaccharide transporter Mal11 in Saccharomyces cerevisiae, which has affinity for sucrose, maltose and glucose.	Maltose	212-219	alpha-glucoside permease	Saccharomyces cerevisiae S288C	145-150
35448589-3	2022	In this study, we applied an evolutionary engineering strategy to alter the substrate specificity of the proton-coupled disaccharide transporter Mal11 in Saccharomyces cerevisiae, which has affinity for sucrose, maltose and glucose.	Glucose	224-231	alpha-glucoside permease	Saccharomyces cerevisiae S288C	145-150
35448589-4	2022	The introduction of MAL11 in a strain devoid of all other sugar transporters and disaccharide hydrolases restored growth on glucose but rendered the strain highly sensitive to the presence of sucrose or maltose.	Glucose	124-131	alpha-glucoside permease	Saccharomyces cerevisiae S288C	20-25
35448589-4	2022	The introduction of MAL11 in a strain devoid of all other sugar transporters and disaccharide hydrolases restored growth on glucose but rendered the strain highly sensitive to the presence of sucrose or maltose.	Sucrose	192-199	alpha-glucoside permease	Saccharomyces cerevisiae S288C	20-25
35448589-4	2022	The introduction of MAL11 in a strain devoid of all other sugar transporters and disaccharide hydrolases restored growth on glucose but rendered the strain highly sensitive to the presence of sucrose or maltose.	Maltose	203-210	alpha-glucoside permease	Saccharomyces cerevisiae S288C	20-25
7925377-5	1994	In contrast, expression of the maltose permease gene (MAL11) and maltose utilization is normal.	Maltose	31-38	alpha-glucoside permease	Saccharomyces cerevisiae S288C	54-59
33279674-1	2021	Proton coupled transport of alpha-glucosides via Mal11 into Saccharomyces cerevisiae costs one ATP per imported molecule.	Adenosine Triphosphate	95-98	alpha-glucoside permease	Saccharomyces cerevisiae S288C	49-54
33279674-5	2021	The localization of mutations and transport properties of the mutants enabled us to propose a mechanistic model of proton-coupled sugar transport by Mal11.	Sugars	130-135	alpha-glucoside permease	Saccharomyces cerevisiae S288C	149-154
33117432-3	2020	Furthermore, this strain showed similar CAT-1 resistance to acetic acid and lactic acid, and it was also able to change the pattern of genes involved in sucrose assimilation (SUC2 and AGT1).	Sucrose	153-160	alpha-glucoside permease	Saccharomyces cerevisiae S288C	184-188
29801806-5	2018	As intracellular water content of S. cerevisiae strain 14 (a strain with moderate tolerance to dehydration-rehydration) was reduced to 1.5 g water/g dry weight, the activity of the Agt1 transporter decreased by 10-15 %.	Water	17-22	alpha-glucoside permease	Saccharomyces cerevisiae S288C	181-185
30221387-7	2018	Their ATP yield from sucrose dissimilation, as estimated from biomass yields in anaerobic chemostat cultures, was the same as that of a congenic strain expressing the native sucrose symporter Mal11p.	Sucrose	174-181	alpha-glucoside permease	Saccharomyces cerevisiae S288C	192-198
31558734-6	2019	The genomic DNA of MC87-46 encodes for isomaltases IMA1, IMA2, IMA3, IMA4 and IMA5, as well as the isomaltose transporter gene, AGT1.	Isomaltose	99-109	alpha-glucoside permease	Saccharomyces cerevisiae S288C	128-132
30466168-0	2019	Key amino acid residues of the AGT1 permease required for maltotriose consumption and fermentation by Saccharomyces cerevisiae.	maltotriose	58-69	alpha-glucoside permease	Saccharomyces cerevisiae S288C	31-35
30466168-1	2019	AIMS: The AGT1 gene encodes for a general alpha-glucoside-H+ symporter required for efficient maltotriose fermentation by Saccharomyces cerevisiae.	alpha-glucoside	42-57	alpha-glucoside permease	Saccharomyces cerevisiae S288C	10-14
30466168-1	2019	AIMS: The AGT1 gene encodes for a general alpha-glucoside-H+ symporter required for efficient maltotriose fermentation by Saccharomyces cerevisiae.	maltotriose	94-105	alpha-glucoside permease	Saccharomyces cerevisiae S288C	10-14
30466168-3	2019	METHODS AND RESULTS: By using a knowledge-driven approach based on charge, conservation, location, three-dimensional (3D) structural modelling and molecular docking analysis, we identified four amino acid residues (Glu-120, Asp-123, Glu-167 and Arg-504) in the AGT1 permease that could mediate substrate binding and translocation.	Glutamic Acid	215-218	alpha-glucoside permease	Saccharomyces cerevisiae S288C	261-265
30466168-3	2019	METHODS AND RESULTS: By using a knowledge-driven approach based on charge, conservation, location, three-dimensional (3D) structural modelling and molecular docking analysis, we identified four amino acid residues (Glu-120, Asp-123, Glu-167 and Arg-504) in the AGT1 permease that could mediate substrate binding and translocation.	Glutamic Acid	233-236	alpha-glucoside permease	Saccharomyces cerevisiae S288C	261-265
29992585-0	2018	Extracellular maltotriose hydrolysis by Saccharomyces cerevisiae cells lacking the AGT1 permease.	maltotriose	14-25	alpha-glucoside permease	Saccharomyces cerevisiae S288C	83-87
29992585-2	2018	Although the AGT1 permease is required for efficient maltotriose fermentation, we have described a new phenotype in some agt1Delta strains of which the cells do not grow on maltotriose during the first 3-4 days of incubation, but after that, they start to grow on the sugar aerobically.	maltotriose	53-64	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-17
29992585-2	2018	Although the AGT1 permease is required for efficient maltotriose fermentation, we have described a new phenotype in some agt1Delta strains of which the cells do not grow on maltotriose during the first 3-4 days of incubation, but after that, they start to grow on the sugar aerobically.	Sugars	268-273	alpha-glucoside permease	Saccharomyces cerevisiae S288C	13-17
29992585-10	2018	The AGT1 permease is required for efficient maltotriose fermentation, but some strains deleted in this gene are still able to grow on maltotriose after an extensive lag phase.	maltotriose	44-55	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
29992585-10	2018	The AGT1 permease is required for efficient maltotriose fermentation, but some strains deleted in this gene are still able to grow on maltotriose after an extensive lag phase.	maltotriose	134-145	alpha-glucoside permease	Saccharomyces cerevisiae S288C	4-8
30007297-0	2018	The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1.	Trehalose	4-13	alpha-glucoside permease	Saccharomyces cerevisiae S288C	108-112
30007297-2	2018	It was not known yet how trehalose, synthesized in the cytosol when dividing Saccharomyces cerevisiae cells are shifted from 28 C to 40 C, is transported to the outside and degraded when cells return to 28 C. According to our results, the lack of Agt1, a trehalose transporter, although had not affected trehalose synthesis, reduced cell tolerance to 51 C and increased lipid peroxidation.	Trehalose	25-34	alpha-glucoside permease	Saccharomyces cerevisiae S288C	247-251
30007297-5	2018	This suggests that Agt1 containing vesicles would fuse with the membrane under 40 C to transport part of the cytosolic trehalose to the outside.	Trehalose	119-128	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-23
29801806-5	2018	As intracellular water content of S. cerevisiae strain 14 (a strain with moderate tolerance to dehydration-rehydration) was reduced to 1.5 g water/g dry weight, the activity of the Agt1 transporter decreased by 10-15 %.	Water	141-146	alpha-glucoside permease	Saccharomyces cerevisiae S288C	181-185
29614773-3	2018	In maltose medium, the expression of MAL11 and MAL31 in MCD4 was 2.1 and 4.2 times significantly higher than that in AK46, respectively.	Maltose	3-10	alpha-glucoside permease	Saccharomyces cerevisiae S288C	37-42
29084970-1	2017	Mal11 catalyzes proton-coupled maltose transport across the plasma membrane of Saccharomyces cerevisiae.	Maltose	31-38	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-5
29084970-3	2017	We find that wildtype Mal11 is extremely well coupled and allows yeast to rapidly accumulate maltose to dangerous levels, resulting under some conditions in self-lysis.	Maltose	93-100	alpha-glucoside permease	Saccharomyces cerevisiae S288C	22-27
28087672-3	2017	A strain in which all known sucrose-transporter genes (MAL11, MAL21, MAL31, MPH2, MPH3) were deleted did not grow on sucrose after 2 months of incubation.	Sucrose	28-35	alpha-glucoside permease	Saccharomyces cerevisiae S288C	55-60
25918382-0	2015	Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.	Trehalose	35-44	alpha-glucoside permease	Saccharomyces cerevisiae S288C	83-87
25035870-0	2014	Three Agt1 transporters from brewer"s yeasts exhibit different temperature dependencies for maltose transport over the range of brewery temperatures (0-20  C).	Maltose	92-99	alpha-glucoside permease	Saccharomyces cerevisiae S288C	6-10
18065618-3	2008	Yeast is also endowed with an acid trehalase encoded by ATH1 and an H+/trehalose transporter encoded by AGT1, which can together sustain assimilation of exogenous trehalose.	Trehalose	71-80	alpha-glucoside permease	Saccharomyces cerevisiae S288C	104-108
23061413-3	2013	Our results indicate that both the MTY1 and AGT1 genes from the S. eubayanus subgenome encode functional maltotriose transporters that allow fermentation of this sugar by yeast cells, despite their apparent differences in the kinetics of maltotriose-H(+)  symport activity.	Sugars	162-167	alpha-glucoside permease	Saccharomyces cerevisiae S288C	44-48
23061413-3	2013	Our results indicate that both the MTY1 and AGT1 genes from the S. eubayanus subgenome encode functional maltotriose transporters that allow fermentation of this sugar by yeast cells, despite their apparent differences in the kinetics of maltotriose-H(+)  symport activity.	maltotriose	105-116	alpha-glucoside permease	Saccharomyces cerevisiae S288C	44-48
20562106-10	2010	Indeed, deletion studies revealed that IMA1/YGR287c encodes the major isomaltase and that growth on isomaltose required the presence of AGT1, which encodes an alpha-glucoside transporter.	Isomaltose	100-110	alpha-glucoside permease	Saccharomyces cerevisiae S288C	136-140
21963484-8	2011	A single-cell isolate showed an 11% higher ethanol yield on sucrose in chemostat cultures than an isogenic SUC2 reference strain, while transcriptome analysis revealed elevated expression of AGT1, encoding a disaccharide-proton symporter, and other maltose-related genes.	Disaccharides	208-220	alpha-glucoside permease	Saccharomyces cerevisiae S288C	191-195
21963484-8	2011	A single-cell isolate showed an 11% higher ethanol yield on sucrose in chemostat cultures than an isogenic SUC2 reference strain, while transcriptome analysis revealed elevated expression of AGT1, encoding a disaccharide-proton symporter, and other maltose-related genes.	Maltose	249-256	alpha-glucoside permease	Saccharomyces cerevisiae S288C	191-195
21755532-1	2011	Agt1 is an interesting alpha-glucoside transporter for the brewing industry, as it efficiently transports maltotriose, a sugar often remaining partly unused during beer fermentation.	maltotriose	106-117	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-4
21755532-1	2011	Agt1 is an interesting alpha-glucoside transporter for the brewing industry, as it efficiently transports maltotriose, a sugar often remaining partly unused during beer fermentation.	Sugars	121-126	alpha-glucoside permease	Saccharomyces cerevisiae S288C	0-4
21755532-2	2011	It has been shown that on maltose the expression level of AGT1 is much higher in ale strains than in lager strains, and that glucose represses the expression, particularly in the ale strains.	Maltose	26-33	alpha-glucoside permease	Saccharomyces cerevisiae S288C	58-62
21755532-10	2011	Under the control of the AGT1 promoter of the ale strain the emergence of GFP was strongly induced by maltose, whereas only a low level of GFP was detected with the construct carrying the AGT1 promoter of the lager strain.	Maltose	102-109	alpha-glucoside permease	Saccharomyces cerevisiae S288C	25-29
21755532-11	2011	Thus, the extra MAL-activator binding element, present in the AGT1 promoter of the ale strain, appears to be necessary to reach a high level of induction by maltose.	Maltose	157-164	alpha-glucoside permease	Saccharomyces cerevisiae S288C	62-66
21755532-12	2011	Both AGT1 promoters were repressed by glucose but their derepression was different, possibly due to a distinct distribution of Mig1 elements in these two promoters.	Glucose	38-45	alpha-glucoside permease	Saccharomyces cerevisiae S288C	5-9
20070441-6	2010	CONCLUSIONS: Our results showed that S. pastorianus yeast strains utilized maltotriose more efficiently than S. cerevisiae strains and highlighted the importance of the AGT1 gene for efficient maltotriose utilization by S. cerevisiae yeasts.	maltotriose	75-86	alpha-glucoside permease	Saccharomyces cerevisiae S288C	169-173
20070441-6	2010	CONCLUSIONS: Our results showed that S. pastorianus yeast strains utilized maltotriose more efficiently than S. cerevisiae strains and highlighted the importance of the AGT1 gene for efficient maltotriose utilization by S. cerevisiae yeasts.	maltotriose	193-204	alpha-glucoside permease	Saccharomyces cerevisiae S288C	169-173
20180115-3	2010	The introduction of AGT1 allows maltose and maltotriose fermentation as well as the improvement of amylase activities.	Maltose	32-39	alpha-glucoside permease	Saccharomyces cerevisiae S288C	20-24
20180115-3	2010	The introduction of AGT1 allows maltose and maltotriose fermentation as well as the improvement of amylase activities.	maltotriose	44-55	alpha-glucoside permease	Saccharomyces cerevisiae S288C	20-24
20402791-8	2010	When functional AGT1 from an ale strain was expressed in a lager strain, the resultant maltose transport activity had the high temperature dependence characteristic of ale yeasts.	Maltose	87-94	alpha-glucoside permease	Saccharomyces cerevisiae S288C	16-20
19181838-0	2009	Improved fermentation performance of a lager yeast after repair of its AGT1 maltose and maltotriose transporter genes.	Maltose	76-83	alpha-glucoside permease	Saccharomyces cerevisiae S288C	71-75
19181838-3	2009	alpha-Glucosides are transported into Saccharomyces yeasts by several transporters, including Agt1, which is a good carrier of both maltose and maltotriose.	alpha-glucosides	0-16	alpha-glucoside permease	Saccharomyces cerevisiae S288C	94-98
19181838-3	2009	alpha-Glucosides are transported into Saccharomyces yeasts by several transporters, including Agt1, which is a good carrier of both maltose and maltotriose.	Maltose	132-139	alpha-glucoside permease	Saccharomyces cerevisiae S288C	94-98
19181838-3	2009	alpha-Glucosides are transported into Saccharomyces yeasts by several transporters, including Agt1, which is a good carrier of both maltose and maltotriose.	maltotriose	144-155	alpha-glucoside permease	Saccharomyces cerevisiae S288C	94-98
19181838-6	2009	Compared to the untransformed strain, the transformants with repaired AGT1 had higher maltose transport activity, especially after growth on glucose (which represses endogenous alpha-glucoside transporter genes) and higher ratios of maltotriose transport activity to maltose transport activity.	Maltose	86-93	alpha-glucoside permease	Saccharomyces cerevisiae S288C	70-74
19181838-6	2009	Compared to the untransformed strain, the transformants with repaired AGT1 had higher maltose transport activity, especially after growth on glucose (which represses endogenous alpha-glucoside transporter genes) and higher ratios of maltotriose transport activity to maltose transport activity.	Glucose	141-148	alpha-glucoside permease	Saccharomyces cerevisiae S288C	70-74
19181838-6	2009	Compared to the untransformed strain, the transformants with repaired AGT1 had higher maltose transport activity, especially after growth on glucose (which represses endogenous alpha-glucoside transporter genes) and higher ratios of maltotriose transport activity to maltose transport activity.	maltotriose	233-244	alpha-glucoside permease	Saccharomyces cerevisiae S288C	70-74
19181838-6	2009	Compared to the untransformed strain, the transformants with repaired AGT1 had higher maltose transport activity, especially after growth on glucose (which represses endogenous alpha-glucoside transporter genes) and higher ratios of maltotriose transport activity to maltose transport activity.	Maltose	267-274	alpha-glucoside permease	Saccharomyces cerevisiae S288C	70-74
18179544-0	2008	The Thr505 and Ser557 residues of the AGT1-encoded alpha-glucoside transporter are critical for maltotriose transport in Saccharomyces cerevisiae.	maltotriose	96-107	alpha-glucoside permease	Saccharomyces cerevisiae S288C	38-42
18179544-1	2008	AIMS: The main objective of this study was to identify amino acid residues in the AGT1-encoded alpha-glucoside transporter (Agt1p) that are critical for efficient transport of maltotriose in the yeast Saccharomyces cerevisiae.	maltotriose	176-187	alpha-glucoside permease	Saccharomyces cerevisiae S288C	82-86
18179544-1	2008	AIMS: The main objective of this study was to identify amino acid residues in the AGT1-encoded alpha-glucoside transporter (Agt1p) that are critical for efficient transport of maltotriose in the yeast Saccharomyces cerevisiae.	maltotriose	176-187	alpha-glucoside permease	Saccharomyces cerevisiae S288C	124-129
18179544-2	2008	METHODS AND RESULTS: The sequences of two AGT1-encoded alpha-glucoside transporters with different efficiencies of maltotriose transport in two Saccharomyces strains (WH310 and WH314) were compared.	maltotriose	115-126	alpha-glucoside permease	Saccharomyces cerevisiae S288C	42-46
18179544-8	2008	CONCLUSIONS: The amino acids Thr(505) and Ser(557), which are respectively located in the transmembrane (TM) segment TM(11) and on the intracellular segment after TM(12) of the AGT1-encoded alpha-glucoside transporters, are critical for efficient transport of maltotriose in S. cerevisiae.	Threonine	29-32	alpha-glucoside permease	Saccharomyces cerevisiae S288C	177-181
18179544-8	2008	CONCLUSIONS: The amino acids Thr(505) and Ser(557), which are respectively located in the transmembrane (TM) segment TM(11) and on the intracellular segment after TM(12) of the AGT1-encoded alpha-glucoside transporters, are critical for efficient transport of maltotriose in S. cerevisiae.	Serine	42-45	alpha-glucoside permease	Saccharomyces cerevisiae S288C	177-181
18179544-8	2008	CONCLUSIONS: The amino acids Thr(505) and Ser(557), which are respectively located in the transmembrane (TM) segment TM(11) and on the intracellular segment after TM(12) of the AGT1-encoded alpha-glucoside transporters, are critical for efficient transport of maltotriose in S. cerevisiae.	maltotriose	260-271	alpha-glucoside permease	Saccharomyces cerevisiae S288C	177-181
18203856-0	2008	Molecular analysis of maltotriose active transport and fermentation by Saccharomyces cerevisiae reveals a determinant role for the AGT1 permease.	maltotriose	22-33	alpha-glucoside permease	Saccharomyces cerevisiae S288C	131-135
18203856-5	2008	While both high- and low-affinity transport activities were responsible for maltose uptake from the medium, in the case of maltotriose, the only low-affinity (K(m), 36 +/- 2 mM) transport activity was mediated by the AGT1 permease.	Maltose	76-83	alpha-glucoside permease	Saccharomyces cerevisiae S288C	217-221
18203856-5	2008	While both high- and low-affinity transport activities were responsible for maltose uptake from the medium, in the case of maltotriose, the only low-affinity (K(m), 36 +/- 2 mM) transport activity was mediated by the AGT1 permease.	maltotriose	123-134	alpha-glucoside permease	Saccharomyces cerevisiae S288C	217-221
18203856-6	2008	In conclusion, the AGT1 transporter is required for efficient maltotriose fermentation by S. cerevisiae yeasts, highlighting the importance of this permease for breeding and/or selection programs aimed at improving sluggish maltotriose fermentations.	maltotriose	62-73	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-23
18203856-6	2008	In conclusion, the AGT1 transporter is required for efficient maltotriose fermentation by S. cerevisiae yeasts, highlighting the importance of this permease for breeding and/or selection programs aimed at improving sluggish maltotriose fermentations.	maltotriose	224-235	alpha-glucoside permease	Saccharomyces cerevisiae S288C	19-23
18304329-6	2008	RESULTS: We have deleted from the genome of a S. cerevisiae strain lacking invertase the high-affinity sucrose-H+ symporter encoded by the AGT1 gene.	Sucrose	103-110	alpha-glucoside permease	Saccharomyces cerevisiae S288C	139-143