PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 1554734-0 1992 Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1. Heparin 24-31 serpin family E member 2 Homo sapiens 48-66 1554734-1 1992 The interaction of heparin with glia-derived nexin (GDN) has been characterized and compared to that observed between heparin and antithrombin III (ATIII). Heparin 19-26 serpin family E member 2 Homo sapiens 32-50 1554734-1 1992 The interaction of heparin with glia-derived nexin (GDN) has been characterized and compared to that observed between heparin and antithrombin III (ATIII). Heparin 19-26 serpin family E member 2 Homo sapiens 52-55 1554734-2 1992 Heparin was fractionated according to its affinity for immobilized GDN, and the ability of various fractions to accelerate the inhibition rate of thrombin by either GDN or ATIII was examined. Heparin 0-7 serpin family E member 2 Homo sapiens 67-70 1554734-4 1992 Slightly greater differences were observed for the effect of these fractions on the thrombin-ATIII reaction; heparin that did not bind to the GDN affinity column was about 60% more effective than heparin with a high affinity for GDN in accelerating the inhibition of thrombin by ATIII. Heparin 196-203 serpin family E member 2 Homo sapiens 229-232 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 76-83 serpin family E member 2 Homo sapiens 21-24 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 76-83 serpin family E member 2 Homo sapiens 130-133 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 76-83 serpin family E member 2 Homo sapiens 130-133 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 190-197 serpin family E member 2 Homo sapiens 21-24 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 190-197 serpin family E member 2 Homo sapiens 130-133 1554734-5 1992 The CNBr fragment of GDN between residues 63 and 144 was able to reduce the heparin-accelerated rate of inhibition of thrombin by GDN indicating that this region of GDN was able to bind the heparin molecules responsible for the acceleration. Heparin 190-197 serpin family E member 2 Homo sapiens 130-133 1554734-8 1992 The results are discussed in terms of the heparin species that are responsible for the acceleration of the GDN- and ATIII-thrombin reactions and the heparin-binding sites of GDN and ATIII. Heparin 42-49 serpin family E member 2 Homo sapiens 107-110 1554734-8 1992 The results are discussed in terms of the heparin species that are responsible for the acceleration of the GDN- and ATIII-thrombin reactions and the heparin-binding sites of GDN and ATIII. Heparin 149-156 serpin family E member 2 Homo sapiens 174-177 2221008-5 1990 In situ hybridization with an 35S-labeled RNA antisense probe for PN-1 resulted in significant labeling of astrocytes and blood vessels. Sulfur-35 30-33 serpin family E member 2 Homo sapiens 66-70 12106474-5 1991 When a mixture of prothrombin and GDN is subjected to either polyacrylamide gel electrophoresis or immunoprecipitation, a stable complex cannot be detected. polyacrylamide 61-75 serpin family E member 2 Homo sapiens 34-37 2221008-6 1990 Because thrombin is known to cause retraction of neurites and modification of astrocytic morphology at low concentrations, PN-1 around blood vessels may play a major protective role against extravasation of thrombin and possibly other serine protease into the human brain. Serine 235-241 serpin family E member 2 Homo sapiens 123-127 34173120-3 2021 SERPINE2 is an extracellular serine proteinase inhibitor with secretory capacity. Serine 29-35 serpin family E member 2 Homo sapiens 0-8 2166058-5 1990 Stable (to SDS) 1:1 molar ratio complex formation between PNI and proteases, the proposed means by which these enzymes are regulated and removed, was also detected. Sodium Dodecyl Sulfate 11-14 serpin family E member 2 Homo sapiens 58-61 2102599-1 1990 The brains of kittens prenatally exposed to ethanol were studied by the rapid-Golgi method at PN1 and PN9 days. Ethanol 44-51 serpin family E member 2 Homo sapiens 94-97 2102599-5 1990 Between days PN1 and PN9 rapid changes occurred in the development of the structural elements of brains of prenatally alcohol exposed kittens. Alcohols 118-125 serpin family E member 2 Homo sapiens 13-16 34365134-2 2022 The zone-wise perturbation for the proteins upon denaturation by Urea and Guanidine hydrochloride (Gdn. Urea 65-69 serpin family E member 2 Homo sapiens 99-102 34365134-2 2022 The zone-wise perturbation for the proteins upon denaturation by Urea and Guanidine hydrochloride (Gdn. Guanidine 74-97 serpin family E member 2 Homo sapiens 99-102 34786856-0 2022 Recent Developments in the Chemistry of Pn(I) (Pn = N, P, As, Sb, Bi) Cations. Nitrogen 52-53 serpin family E member 2 Homo sapiens 40-45 34786856-0 2022 Recent Developments in the Chemistry of Pn(I) (Pn = N, P, As, Sb, Bi) Cations. Phosphorus 55-56 serpin family E member 2 Homo sapiens 40-45 34786856-0 2022 Recent Developments in the Chemistry of Pn(I) (Pn = N, P, As, Sb, Bi) Cations. Arsenic 58-60 serpin family E member 2 Homo sapiens 40-45 34786856-0 2022 Recent Developments in the Chemistry of Pn(I) (Pn = N, P, As, Sb, Bi) Cations. Antimony 62-64 serpin family E member 2 Homo sapiens 40-45 34786856-0 2022 Recent Developments in the Chemistry of Pn(I) (Pn = N, P, As, Sb, Bi) Cations. Bismuth 66-68 serpin family E member 2 Homo sapiens 40-45 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. Nitrogen 33-34 serpin family E member 2 Homo sapiens 13-18 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. Phosphorus 36-37 serpin family E member 2 Homo sapiens 13-18 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. Arsenic 39-41 serpin family E member 2 Homo sapiens 13-18 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. Antimony 43-45 serpin family E member 2 Homo sapiens 13-18 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. Bismuth 50-52 serpin family E member 2 Homo sapiens 13-18 34786856-1 2022 The Group 15 Pn(I) cations (Pn = N, P, As, Sb and Bi), which are isoelectronic with the donor-stabilized carbones, have emerged recently. carbones 105-113 serpin family E member 2 Homo sapiens 13-18 34648881-8 2022 In summary, these findings indicate a novel regulatory mechanism by which SERPINE2 modulates the DDR and radioresistance in lung cancer. ddr 97-100 serpin family E member 2 Homo sapiens 74-82 34904615-4 2021 Herein, we have developed five either free base or transition metalated porphyrin-napthalimide based donor-acceptor systems (PN1-PN5) and studied their morphology, electronic properties and catalytic behaviour. porphyrin-napthalimide 72-94 serpin family E member 2 Homo sapiens 125-128 34611254-6 2021 Among the PNI/LVI double negative, single positive to double positive subgroups, increasing LN+, DM rates and decreasing DSS rate were observed. dss 121-124 serpin family E member 2 Homo sapiens 10-17 34611254-7 2021 Among the 44 LN+ patients, PNI/LVI double positive remained associated with a markedly high DM rate of 42.9% and a poor 5-year DSS of 27.7%. dss 127-130 serpin family E member 2 Homo sapiens 27-34 34611254-8 2021 PNI/LVI double positive plays important roles in prognostication and potential clinical application for T3-4 OSCC by independently predicting LN+, DM, and poor DSS, and can be used as a good marker to select DM high-risk patients for novel adjuvant therapy trials. dss 160-163 serpin family E member 2 Homo sapiens 0-7 34173120-4 2021 Although SERPINE2 displays tumor-promoting properties in many cancers, some reports indicate that SRPINE2 also has a tumor-suppressing function. srpine2 98-105 serpin family E member 2 Homo sapiens 9-17 35127498-4 2021 This study aims to evaluate the clinical value of the new score system by combining SII and PNI (SII-PNI score) as a predictor of efficacy and prognosis after neoadjuvant intraperitoneal and systemic (NIPS) paclitaxel combined with Apatinib conversion therapy for GC-CY1 patients. Paclitaxel 207-217 serpin family E member 2 Homo sapiens 101-104 35166426-9 2022 On multivariable logistic regression analysis, the intraprostatic SUVmax was an independent predictor of pN1 for both 68 Ga-PSMA-11 (per doubling: odds ratio (OR) 1.96 (95% Confidence Interval (CI) 1.27-3.01)) and 18 F-PSMA (per doubling: OR 1.79 (95%CI 1.06-3.03). Gallium 121-123 serpin family E member 2 Homo sapiens 105-108 35381514-3 2022 Vinyltrimethoxysilane and thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) was grafted onto the surface of the CCNT/CA skeleton, and the resulting smart aerogel (PNI-Si@CCNT/CA) exhibited temperature responsiveness. trimethoxyvinylsilane 0-21 serpin family E member 2 Homo sapiens 168-171 35381514-3 2022 Vinyltrimethoxysilane and thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) was grafted onto the surface of the CCNT/CA skeleton, and the resulting smart aerogel (PNI-Si@CCNT/CA) exhibited temperature responsiveness. poly-N-isopropylacrylamide 43-70 serpin family E member 2 Homo sapiens 168-171 35381514-3 2022 Vinyltrimethoxysilane and thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) was grafted onto the surface of the CCNT/CA skeleton, and the resulting smart aerogel (PNI-Si@CCNT/CA) exhibited temperature responsiveness. poly-N-isopropylacrylamide 72-79 serpin family E member 2 Homo sapiens 168-171 35381514-4 2022 PNI-Si@CCNT/CA exhibited an excellent reversible conversion between hydrophilicity and hydrophobicity when the temperature was changed to below or above the lower critical solution temperature (LCST) of PNIPAAm (~32 C). poly-N-isopropylacrylamide 203-210 serpin family E member 2 Homo sapiens 0-3 35381514-6 2022 Moreover, PNI-Si@CCNT/CA absorbed oil at 45 C and released the absorbed oil at 25 C. It maintained its good adsorption performance after 15 cycles, and this was ascribed to its excellent mechanical properties and stable structure. Oils 34-37 serpin family E member 2 Homo sapiens 10-13 35089513-9 2022 Hg demonstrates lowest connection with TOC (PHg-TOC ~ 0) but individual heavy metal correlations are largely positive, with many reaching 1.0 (e.g., PNi-Cr = 0.89, PCd-As = 0.72, PNi-Cu = 0.76, and PCu-Cr = 0.72). Metals 78-83 serpin family E member 2 Homo sapiens 149-152 35127498-4 2021 This study aims to evaluate the clinical value of the new score system by combining SII and PNI (SII-PNI score) as a predictor of efficacy and prognosis after neoadjuvant intraperitoneal and systemic (NIPS) paclitaxel combined with Apatinib conversion therapy for GC-CY1 patients. apatinib 232-240 serpin family E member 2 Homo sapiens 101-104 35127498-14 2021 Conclusion: Pretreatment SII-PNI score is an important predictor for the efficacy of GC-CY1 patients after NIPS paclitaxel combined with Apatinib conversion therapy, which can help to identify high-risk groups and predict prognosis. Paclitaxel 112-122 serpin family E member 2 Homo sapiens 29-32 35127498-14 2021 Conclusion: Pretreatment SII-PNI score is an important predictor for the efficacy of GC-CY1 patients after NIPS paclitaxel combined with Apatinib conversion therapy, which can help to identify high-risk groups and predict prognosis. apatinib 137-145 serpin family E member 2 Homo sapiens 29-32 3378053-0 1988 Purification of a form of protease nexin 1 that binds heparin with a low affinity. Heparin 54-61 serpin family E member 2 Homo sapiens 26-42 35056831-4 2022 The surfactant-like functionalities in side chains of PNI-SBMA endow the NFMs with outstanding hydrophilicity, and the naphthimide derivatives are sensitive to pH by photoinduced electron transfer effect, which contribute to highly efficient pH fluorescence sensing applications of NFMs. naphthimide 119-130 serpin family E member 2 Homo sapiens 54-57 2813392-1 1989 Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic site serine of the protease. Sodium Dodecyl Sulfate 118-121 serpin family E member 2 Homo sapiens 0-16 2813392-1 1989 Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic site serine of the protease. Sodium Dodecyl Sulfate 118-121 serpin family E member 2 Homo sapiens 18-22 2813392-1 1989 Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic site serine of the protease. Serine 163-169 serpin family E member 2 Homo sapiens 0-16 2813392-1 1989 Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic site serine of the protease. Serine 163-169 serpin family E member 2 Homo sapiens 18-22 2799763-4 1989 Fractionation of VSMC-conditioned medium by heparin-affigel chromatography separated three immunologically and functionally distinct PA inhibitors (PAI), namely PAI-1, PAI-2 and protease-nexin I. vsmc 17-21 serpin family E member 2 Homo sapiens 178-194 2786418-3 1989 Two distinct species of complexes (91 and 122 kDa) are observed upon SDS-PAGE analysis of the reacted proteins, indicating that PN-1 is capable of complexing and inhibiting both subunits of the homodimeric TSP-1 molecule. Sodium Dodecyl Sulfate 69-72 serpin family E member 2 Homo sapiens 128-132 2920011-4 1989 Association rate constants of both gdN and antithrombin III with alpha-thrombin were obtained using unfractionated, low- and high-affinity heparin types. Heparin 139-146 serpin family E member 2 Homo sapiens 35-38 3378053-1 1988 A form of protease nexin 1 (PN-1) that binds heparin with a low affinity (L-PN-1) was purified and studies since altered interactions with glycosaminoglycans could affect its inhibition of certain serine proteases. Heparin 45-52 serpin family E member 2 Homo sapiens 10-26 3378053-1 1988 A form of protease nexin 1 (PN-1) that binds heparin with a low affinity (L-PN-1) was purified and studies since altered interactions with glycosaminoglycans could affect its inhibition of certain serine proteases. Heparin 45-52 serpin family E member 2 Homo sapiens 28-32 3378053-1 1988 A form of protease nexin 1 (PN-1) that binds heparin with a low affinity (L-PN-1) was purified and studies since altered interactions with glycosaminoglycans could affect its inhibition of certain serine proteases. Glycosaminoglycans 139-157 serpin family E member 2 Homo sapiens 10-26 3378053-1 1988 A form of protease nexin 1 (PN-1) that binds heparin with a low affinity (L-PN-1) was purified and studies since altered interactions with glycosaminoglycans could affect its inhibition of certain serine proteases. Glycosaminoglycans 139-157 serpin family E member 2 Homo sapiens 28-32 3378053-2 1988 Purification of L-PN-1 and PN-1 was achieved by fractionating serum-free conditioned culture medium from human fibroblasts over dextran sulfate-Sepharose followed by immunoaffinity fractionation over a PN-1 monoclonal antibody-Sepharose column. Dextran Sulfate 128-143 serpin family E member 2 Homo sapiens 16-31 3378053-2 1988 Purification of L-PN-1 and PN-1 was achieved by fractionating serum-free conditioned culture medium from human fibroblasts over dextran sulfate-Sepharose followed by immunoaffinity fractionation over a PN-1 monoclonal antibody-Sepharose column. Sepharose 144-153 serpin family E member 2 Homo sapiens 16-31 3378053-2 1988 Purification of L-PN-1 and PN-1 was achieved by fractionating serum-free conditioned culture medium from human fibroblasts over dextran sulfate-Sepharose followed by immunoaffinity fractionation over a PN-1 monoclonal antibody-Sepharose column. Sepharose 227-236 serpin family E member 2 Homo sapiens 16-31 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 41-48 serpin family E member 2 Homo sapiens 147-151 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 41-48 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 41-48 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 41-48 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 147-151 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 147-151 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3378053-5 1988 Studies on activities that depend on the heparin binding domain revealed that heparin equally accelerated the rate of formation of 125I-thrombin-L-PN-1 and 125I-thrombin-PN-1 complexes even when the ratio of heparin to L-PN-1 or PN-1 was varied from 0.01 to 100. Heparin 78-85 serpin family E member 2 Homo sapiens 170-174 3040175-5 1987 In addition, the inhibitor co-migrates with PN-I on SDS-PAGE and cross-reacts with anti-PN-I antibody on immunoblots. Sodium Dodecyl Sulfate 52-55 serpin family E member 2 Homo sapiens 44-48 3279057-8 1988 Extraction of the matrix with 2 M NaCl removed PN-1 in a form which reacted with 125I-thrombin to form complexes which were immunoprecipitated by anti-PN-1 IgG and were of identical size as complexes made from soluble PN-1 and 125I-thrombin. Sodium Chloride 34-38 serpin family E member 2 Homo sapiens 47-51 2959275-2 1987 PN-1 inhibits certain regulatory serine proteinases by forming a covalent complex with the catalytic-site serine residue; the complex then binds to the cell surface and is internalized and degraded. Serine 33-39 serpin family E member 2 Homo sapiens 0-4 3034924-6 1987 At 4 degrees C binding of PN-I:protease complexes was competed by heparin. Heparin 66-73 serpin family E member 2 Homo sapiens 26-30 3102483-4 1987 The complexes are of the appropriate size, bind to Sepharose that has been derivatized with anti-PNI antibody, do not form when the thrombin active site has been blocked with diisopropylphosphofluoridate, and do not appear on platelets when heparin is present. Sepharose 51-60 serpin family E member 2 Homo sapiens 97-100 3565746-14 1987 125I-Fluoresceinamine-derivatized heparin retains its ability to interact specifically with heparin-binding proteins such as human protease nexin-I and antithrombin III. 125i-fluoresceinamine 0-21 serpin family E member 2 Homo sapiens 131-147 3565746-14 1987 125I-Fluoresceinamine-derivatized heparin retains its ability to interact specifically with heparin-binding proteins such as human protease nexin-I and antithrombin III. Heparin 34-41 serpin family E member 2 Homo sapiens 131-147 3569329-5 1987 Among 248 pN1 patients therapy with tamoxifen had an influence on free interval both in the group with a low receptorial status and in particular in that with high receptorial level; no effects of therapy on the ER- patients. Tamoxifen 36-45 serpin family E member 2 Homo sapiens 10-13 6317700-4 1983 In addition, whereas the ability of PN-I to link to thrombin is strongly modulated by heparin, PN-II and PN-III are essentially unaffected by heparin. Heparin 86-93 serpin family E member 2 Homo sapiens 36-40 3771529-3 1986 PN-I preferentially binds thrombin, urokinase, trypsin, and plasmin, and its binding to thrombin is accelerated by heparin. Heparin 115-122 serpin family E member 2 Homo sapiens 0-4 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. Sodium Dodecyl Sulfate 157-179 serpin family E member 2 Homo sapiens 10-14 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. Sodium Dodecyl Sulfate 157-179 serpin family E member 2 Homo sapiens 70-74 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. Sodium Dodecyl Sulfate 157-179 serpin family E member 2 Homo sapiens 70-74 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. Sodium Dodecyl Sulfate 157-179 serpin family E member 2 Homo sapiens 70-74 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. polyacrylamide 180-194 serpin family E member 2 Homo sapiens 10-14 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. polyacrylamide 180-194 serpin family E member 2 Homo sapiens 70-74 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. polyacrylamide 180-194 serpin family E member 2 Homo sapiens 70-74 3771529-6 1986 Unlabeled PN-I could compete for the binding of metabolically labeled PN-I to anti-PN-I, as shown by the elimination of the 43-kDa band representing PN-I on sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiographs. polyacrylamide 180-194 serpin family E member 2 Homo sapiens 70-74 3771529-15 1986 The PN-I precursor was also sensitive to endoglycosidase H, suggesting that it contains N-linked carbohydrates of the high mannose form. n-linked carbohydrates 88-110 serpin family E member 2 Homo sapiens 4-8 3771529-15 1986 The PN-I precursor was also sensitive to endoglycosidase H, suggesting that it contains N-linked carbohydrates of the high mannose form. Mannose 123-130 serpin family E member 2 Homo sapiens 4-8 3771529-16 1986 Mature PN-I is not sensitive to endoglycosidase H, but does contain 3 kDa of N-linked carbohydrate. n-linked carbohydrate 77-98 serpin family E member 2 Homo sapiens 7-11 33046986-5 2020 In 159 pN1-2 patients, the taxane-based three-drug regimen significantly improved DFS (5-year DFS rate, 78.2% vs. 46.9%; log-rank p=0.0002) and OS (5-year OS rate, 90.7% vs. 64.3%; log-rank p=0.0001) compared with the two-drug regimen. taxane 27-33 serpin family E member 2 Homo sapiens 7-10 6579053-1 1983 Four criteria were used to examine serum-free conditioned cell culture medium for protease nexin (PN):(1) formation of SDS-stable approximately 77 K Da complexes between a medium component and [125I]thrombin; (2) acceleration by heparin of the rate of formation of these complexes; (3) cellular binding of these complexes; and (4) inhibition by heparin of the cellular binding of complexes. Sodium Dodecyl Sulfate 119-122 serpin family E member 2 Homo sapiens 82-104 6579053-1 1983 Four criteria were used to examine serum-free conditioned cell culture medium for protease nexin (PN):(1) formation of SDS-stable approximately 77 K Da complexes between a medium component and [125I]thrombin; (2) acceleration by heparin of the rate of formation of these complexes; (3) cellular binding of these complexes; and (4) inhibition by heparin of the cellular binding of complexes. Heparin 229-236 serpin family E member 2 Homo sapiens 82-104 133497-4 1976 Improved gelatin aldehyde impregnation on the dacron covered diaphragm of cardiac prostheses resulted in a reduced PNI thickness and minimized interfacial degeneration of PNI. Aldehydes 17-25 serpin family E member 2 Homo sapiens 115-118 133497-10 1976 The aldehyde treated pericardial surface of cardiac prostheses generated a thin PNI that was fibrin-rich, a viable cell infiltration, no interfacial degeneration, and endothelial-like cells on its surface. Aldehydes 4-12 serpin family E member 2 Homo sapiens 80-83 33674271-1 2021 As a partner antimalarial with an extremely long elimination half-life (~30 days), piperaquine (PQ) is mainly metabolized into a pharmacologically active N-oxide metabolite (PN1) in humans. piperaquine 83-94 serpin family E member 2 Homo sapiens 174-177 33674271-1 2021 As a partner antimalarial with an extremely long elimination half-life (~30 days), piperaquine (PQ) is mainly metabolized into a pharmacologically active N-oxide metabolite (PN1) in humans. piperaquine 96-98 serpin family E member 2 Homo sapiens 174-177 33674271-1 2021 As a partner antimalarial with an extremely long elimination half-life (~30 days), piperaquine (PQ) is mainly metabolized into a pharmacologically active N-oxide metabolite (PN1) in humans. n-oxide 154-161 serpin family E member 2 Homo sapiens 174-177 33674271-3 2021 The results showed that interconversion existed for PQ and its metabolite PN1. piperaquine 52-54 serpin family E member 2 Homo sapiens 74-77 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. Nitrogen 4-5 serpin family E member 2 Homo sapiens 25-28 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. Nitrogen 4-5 serpin family E member 2 Homo sapiens 64-67 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. piperaquine 19-21 serpin family E member 2 Homo sapiens 25-28 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. piperaquine 19-21 serpin family E member 2 Homo sapiens 64-67 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. piperaquine 95-97 serpin family E member 2 Homo sapiens 25-28 33674271-4 2021 The N-oxidation of PQ to PN1 was mainly mediated by CYP3A4, and PN1 can rapidly reduce back to PQ via CYP/FMO enzymes. piperaquine 95-97 serpin family E member 2 Homo sapiens 64-67 33278189-7 2020 They are inhibited by protease nexin 1 or serine E2 (PN1) that is upregulated by angiotensin II but downregulated by aldosterone. Serine 42-48 serpin family E member 2 Homo sapiens 53-56 33278189-7 2020 They are inhibited by protease nexin 1 or serine E2 (PN1) that is upregulated by angiotensin II but downregulated by aldosterone. Aldosterone 117-128 serpin family E member 2 Homo sapiens 53-56 33278189-11 2020 We review the evidence that spironolactone may be the preferred RASSi to increase PN1 and decrease TMPRSS2, furin and plasmin activities and thereby to reduce viral cell binding, entry, infectivity and bad outcomes. Spironolactone 28-42 serpin family E member 2 Homo sapiens 82-85 1214797-4 1975 CD spectrum of poly (I+C) double complex is changed considerably upon addition of D-d: CD increases when P/N ratio is 10:1, decreases at P/N 1:1 and comes back to the initial spectrum at P/N 1:5. Cadmium 0-2 serpin family E member 2 Homo sapiens 187-194 1214797-4 1975 CD spectrum of poly (I+C) double complex is changed considerably upon addition of D-d: CD increases when P/N ratio is 10:1, decreases at P/N 1:1 and comes back to the initial spectrum at P/N 1:5. Poly I-C 15-25 serpin family E member 2 Homo sapiens 187-194 1214797-4 1975 CD spectrum of poly (I+C) double complex is changed considerably upon addition of D-d: CD increases when P/N ratio is 10:1, decreases at P/N 1:1 and comes back to the initial spectrum at P/N 1:5. Cadmium 87-89 serpin family E member 2 Homo sapiens 187-194 33629802-6 2021 Therefore, the optimized mobile phase consisting of 20 mmol NaH2 PO4 and 20 mmol NaClO4 (adding H3 PO4 to adjust pH = 2) was used to separate PN1-1# . sodium perchlorate 81-87 serpin family E member 2 Homo sapiens 142-145 33046986-6 2020 In a multivariable Cox regression analysis of pN1-2 patients, after adjustment for clinical characteristics, the taxane-based three-drug regimen significantly decreased the risk of recurrence (adjusted HR, 0.37; 95% CI, 0.22 to 0.64; p=0.0004) and death (adjusted HR, 0.22; 95% CI, 0.10 to 0.48; p=0.0001) compared with the two-drug regimen. taxane 113-119 serpin family E member 2 Homo sapiens 46-49 32495984-1 2020 BACKGROUND: Protease nexin-1 (PN-1) is a member of the serine protease inhibitor (Serpin)-family, with thrombin as its main target. Serine 55-61 serpin family E member 2 Homo sapiens 30-34 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. Anthraquinones 38-51 serpin family E member 2 Homo sapiens 78-81 32164621-7 2020 RESULTS: In this 78 patient cohort, high TB was significantly associated with advanced tumor status (pT4: 50.0% vs 22.2%, p = 0.007, pN1/2: 70.8% vs 39.6%, p = 0.011, M1: 20.8% vs 1.9%) and higher histological grade (G3: 25.0% vs 5.7%, p = 0.014). Terbium 41-43 serpin family E member 2 Homo sapiens 133-138 32246186-5 2020 RESULTS: During the study period, 628 patients with PNI were treated at GSH. Glutathione 72-75 serpin family E member 2 Homo sapiens 52-55 32515970-3 2020 [Ag (PhTSC HCl) 2] (NO3) H2O (compound 1) was synthesized, characterized, and loaded into polymeric nanoparticles (PN1). Water 26-29 serpin family E member 2 Homo sapiens 116-119 32515970-4 2020 PN1 had been developed by nanoprecipitation with poly (epsilon- caprolactone) polymer and poloxamer 407 surfactant. poly (epsilon- caprolactone) polymer 49-85 serpin family E member 2 Homo sapiens 0-3 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. poly(vinylanthraquinone) 83-86 serpin family E member 2 Homo sapiens 78-81 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. N-isopropylacrylamide 272-293 serpin family E member 2 Homo sapiens 78-81 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. N-isopropylacrylamide 295-300 serpin family E member 2 Homo sapiens 78-81 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. poly(vinylanthraquinone) 318-338 serpin family E member 2 Homo sapiens 78-81 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. poly(vinylanthraquinone) 340-343 serpin family E member 2 Homo sapiens 78-81 32053750-2 2020 In this work, we reported a series of anthraquinone functionalized microgels (PNI-xVAQ) with thermo-sensitivity, redox-actuated self-regulating color, size and fluorescent properties, which were easily synthesized via surfactant free emulsion copolymerization (SFEP) with N-isopropylacrylamide (NIPAm) as the monomer, 2-vinylanthraquinone (VAQ) as the comonomer, and N,N"-methylenebisacrylamide (BIS) as the cross-linker in an aqueous solution at 70 oC. N,N'-methylenebisacrylamide 367-394 serpin family E member 2 Homo sapiens 78-81 32053750-3 2020 The hydrophobic interactions of comonomer VAQ also led to the formation of internal phase-separated hydrophobic nanodomains in the obtained PNI-xVAQ microgels. poly(vinylanthraquinone) 42-45 serpin family E member 2 Homo sapiens 140-143 32053750-3 2020 The hydrophobic interactions of comonomer VAQ also led to the formation of internal phase-separated hydrophobic nanodomains in the obtained PNI-xVAQ microgels. poly(vinylanthraquinone) 145-148 serpin family E member 2 Homo sapiens 140-143 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. poly(vinylanthraquinone) 69-72 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Anthraquinones 135-148 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Dithionite 168-185 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Anthraquinones 267-280 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Anthraquinones 267-280 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Anthraquinones 267-280 serpin family E member 2 Homo sapiens 64-67 32053750-4 2020 The self-regulating color, size and fluorescence changes of the PNI-xVAQ microgels were relied on the non-equilibrium redox process of anthraquinone moieties by adding sodium dithionite as the chemical fuel to activate the positive feedback that was the reduction of anthraquinone to transient anthraquinone radical anions, followed the slow oxidation of anthraquinone radical anions by autonomous "breathing" oxygen in air as the delayed negative feedback. Oxygen 410-416 serpin family E member 2 Homo sapiens 64-67 32053750-5 2020 These autonomous self-regulating properties of the PNI-xVAQ microgel were recyclable to certain extent by repeated feeding of sodium dithionite. poly(vinylanthraquinone) 56-59 serpin family E member 2 Homo sapiens 51-54 32053750-5 2020 These autonomous self-regulating properties of the PNI-xVAQ microgel were recyclable to certain extent by repeated feeding of sodium dithionite. Dithionite 126-143 serpin family E member 2 Homo sapiens 51-54 31148462-5 2019 Methods: Sixty patients (53 +- 13years, 77% males) with PNI were treated with pBONT-A after a test injection with a local anesthetic, which prompted distinctive pain relief. pbont-a 78-85 serpin family E member 2 Homo sapiens 56-59 31756088-3 2020 The adhesion of different cell types (4T1, HEK293, H9C2, HUVEC, and L929) can be easily modulated by varying the thickness of PNIPAAm brushes from 5.9+-1.0 nm (PN1) to 69.0+-5.0 nm (PN6). N-isopropylacrylamide 126-133 serpin family E member 2 Homo sapiens 160-163 31215134-1 2019 BACKGROUND: The present study aimed to investigate the relationship between seven polymorphisms of the serine protease inhibitor-2 (SERPINE2) gene and the risk of chronic obstructive pulmonary disease (COPD) in the Uygur population via a case-control study. Serine 103-109 serpin family E member 2 Homo sapiens 132-140 30823588-5 2019 The five-year overall survival (OS) and disease-specific survival (DSS) in pN1-3 OSCC patients were 62% and 71%, respectively. dss 67-70 serpin family E member 2 Homo sapiens 75-78 31158311-1 2019 We report the formation of a new copper peroxynitrite (PN) complex [CuII (TMG3 tren)(kappa1 -OONO)]+ (PN1) from the reaction of [CuII (TMG3 tren)(O2 .- )]+ (1) with NO. copper peroxynitrite 33-53 serpin family E member 2 Homo sapiens 102-105 31158311-1 2019 We report the formation of a new copper peroxynitrite (PN) complex [CuII (TMG3 tren)(kappa1 -OONO)]+ (PN1) from the reaction of [CuII (TMG3 tren)(O2 .- )]+ (1) with NO. Peroxynitrous Acid 55-57 serpin family E member 2 Homo sapiens 102-105 31158311-3 2019 PN1 transforms thermally into an isomeric form (PN2) with kappa2 -O,O"-(- OONO) coordination, which undergoes O-O bond homolysis to generate a putative cupryl (LCuII -O. ) cupryl 152-158 serpin family E member 2 Homo sapiens 0-3 31100839-2 2019 We retrospectively analyzed the clinical data of patients with pN1 breast cancer who underwent partial mastectomy and taxane-based sequential adjuvant chemotherapy with postoperative radiation therapy in 12 hospitals (n = 1121). taxane 118-124 serpin family E member 2 Homo sapiens 63-66 30785826-16 2019 Six cycles of TC is an effective/safe option in human epidermal growth factor receptor 2-negative EBC with pN0 high genomic risk or pN1 EBC with genomically intermediate- to high-risk disease. Technetium 14-16 serpin family E member 2 Homo sapiens 132-135 29285831-6 2018 According to the current and proposed N classification, the 5-year CSS of penile cancer patients with pN1, pN2 and pN3 was 85.8%, 39.0%, and 19.7%; and with pN1, pN2 and pN3 was 79.8%, 39.3% and 15.3%, which almost all showed significant difference (P < .001, P = .259) (P < .001, P < .001). thiocysteine 67-70 serpin family E member 2 Homo sapiens 102-105 30159726-7 2018 Survival analysis demonstrated that patients with pN0 to pN1 had better OS (P = 0.02), disease-specific survival (DSS) (P = 0.003), DFS (P = 0.02) and metastases free survival (MFS) (P = 0.002) compared to patients with pN2 to pN3. dss 114-117 serpin family E member 2 Homo sapiens 57-60 30545809-1 2018 BACKGROUND: In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. adt 326-329 serpin family E member 2 Homo sapiens 118-121 30545809-1 2018 BACKGROUND: In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. adt 419-422 serpin family E member 2 Homo sapiens 118-121 30527231-10 2018 CONCLUSION: This propensity-matched analysis suggests that RAI therapy after TT was associated with improved OS in PTC patients with pN1 disease. Insulin, Short-Acting 59-62 serpin family E member 2 Homo sapiens 133-136 28415740-2 2017 RESULTS: On multivariate analyses of the derivation set, the nomograms for OS and CSS shared common significant prognostic factors: age, first-degree relative cancer history, differentiation grade, vessels/nerves invasion, TNM stage, CEA, CA19-9 and PNI. Osmium 75-77 serpin family E member 2 Homo sapiens 250-253 28940496-3 2017 We sought to assess the incidence and prognosis of left-sided PNI during CBA. cba 73-76 serpin family E member 2 Homo sapiens 62-65 28501481-5 2017 RESULTS: The 5-year disease-free survival (DFS) and cancer-specific survival (CSS) rate were higher in pN0 patients than in pNx patients and in pN1/2 patients. thiocysteine 78-81 serpin family E member 2 Homo sapiens 144-147 28101585-11 2017 CONCLUSIONS: Patients with pN1 PCa treated with wpRT and 2-3 years ADT have an encouraging 5-year CSS. thiocysteine 98-101 serpin family E member 2 Homo sapiens 27-30 28975405-10 2017 RESULTS: Microarray data showed that SERPINE1 and SERPINE2 increased most dramatically under carboplatin treatment in A2780cp cells. Carboplatin 93-104 serpin family E member 2 Homo sapiens 50-58 29074847-5 2017 Stage migration occurred in pN1 and pN2 patients with LODDS 4. lodds 4 54-61 serpin family E member 2 Homo sapiens 28-31 29074847-6 2017 In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. lodds 28-33 serpin family E member 2 Homo sapiens 3-6 29074847-6 2017 In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. dss 57-60 serpin family E member 2 Homo sapiens 3-6 29074847-6 2017 In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. Osmium 73-75 serpin family E member 2 Homo sapiens 3-6 29074847-6 2017 In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3. lodds 111-116 serpin family E member 2 Homo sapiens 3-6 28453461-2 2017 SerpinE2 (a small ubiquitin-related modifier), like ubiquitin, conjugates SerpinE2 proteins onto lysine residues of target proteins. Lysine 97-103 serpin family E member 2 Homo sapiens 0-8 28453461-2 2017 SerpinE2 (a small ubiquitin-related modifier), like ubiquitin, conjugates SerpinE2 proteins onto lysine residues of target proteins. Lysine 97-103 serpin family E member 2 Homo sapiens 74-82 28415740-2 2017 RESULTS: On multivariate analyses of the derivation set, the nomograms for OS and CSS shared common significant prognostic factors: age, first-degree relative cancer history, differentiation grade, vessels/nerves invasion, TNM stage, CEA, CA19-9 and PNI. thiocysteine 82-85 serpin family E member 2 Homo sapiens 250-253 28068243-17 2017 The better than expected outcomes observed in the lower quartiles of BCR prediction suggest a role for SLN biopsy as a potential selection tool for the addition of pelvic radiation therapy and ADT intensification in pN1 patients. adt 193-196 serpin family E member 2 Homo sapiens 216-219 24212239-8 2014 In patients with CPV, the 5-year survival rate was 56% for patients with no LN metastasis and 44% and 0% for patients with pN1 disease but without extracapsular LN involvement and patients with pN1 disease with extracapsular LN involvement of at least 1 LN, respectively (P = 0.006). Cyclopropavir 17-20 serpin family E member 2 Homo sapiens 123-126 24336069-12 2014 In conclusion, these data suggest that in addition to an acidification dysfunction caused by the CLCN7 mutation, a change in ITGB5, PRF1, WARS, and SERPINE2 expression could be part of the osteoclastic phenotype of ADO II. ado ii 215-221 serpin family E member 2 Homo sapiens 148-156 25605166-11 2014 CONCLUSIONS: Pathologic GS >=9 and pN1 were independent predictors of clinical metastasis in post-prostatectomy patients who received immediate adjuvant ADT. adt 156-159 serpin family E member 2 Homo sapiens 38-41 27445860-5 2016 We hypothesized that plasmin-PN-1 complexes could be internalized via LRP-1 by vSMCs during the early stages of human atheroma. vsmcs 79-84 serpin family E member 2 Homo sapiens 29-33 26829761-1 2016 OBJECTIVES: To comprehend the merits of a Manual Tactile Test (MTT) in assessing hand sensorimotor functions by exploring the relations among 3 subtests along with the precision pinch performances for patients with peripheral nerve injuries (PNIs); and to understand the accuracy of the MTT by constructing the sensitivity and specificity of the test for patients with PNI. monooxyethylene trimethylolpropane tristearate 63-66 serpin family E member 2 Homo sapiens 242-245 26829761-8 2016 Multiple linear regression analysis showed the MTT was a better indicator for predicting the sensorimotor capacity of hands in the patients with PNI (r(2)=.189, P=.003) than the traditional test (r(2)=.088, P=.051). monooxyethylene trimethylolpropane tristearate 47-50 serpin family E member 2 Homo sapiens 145-148 26829761-9 2016 The results of the receiver operating characteristic curve estimation show that the area under the curve was .968 and .959 for the roughness differentiation and stereognosis subtests, respectively, and .853 for the barognosis subtest, therefore revealing the accuracy of the MTT in assessing sensorimotor status for patients with PNI. monooxyethylene trimethylolpropane tristearate 275-278 serpin family E member 2 Homo sapiens 330-333 26829761-10 2016 CONCLUSIONS: This study indicates that the MTT is highly accurate and a significant predictor of sensorimotor performance in hands of patients with PNI. monooxyethylene trimethylolpropane tristearate 43-46 serpin family E member 2 Homo sapiens 148-151 27188608-14 2016 Patients younger than 40, with histological grade II or III tumor and with pN1 or pN2 status are prone to receive OFS. ofs 114-117 serpin family E member 2 Homo sapiens 75-78 26910282-8 2016 However, melanin levels measured in pT3-pT4 melanomas developing metastases (pN1-3, pM1) were higher than in pN0 and pM0 cases. Melanins 9-16 serpin family E member 2 Homo sapiens 77-80 26829704-3 2016 Device resistance measurements, determined as a function of PM(n) molecular length, were utilized to evaluate the magnitude of a phenomenological beta corresponding to the resistance decay parameter across the barrier; these data show that the magnitude of this beta value is modulated via porphyrin macrocycle central metal atom substitution [beta(PZn(n); 0.065 A(-1)) < beta(PCu(n); 0.132 A(-1)) < beta(PNi(n); 0.176 A(-1))]. Metals 319-324 serpin family E member 2 Homo sapiens 411-414 26829704-3 2016 Device resistance measurements, determined as a function of PM(n) molecular length, were utilized to evaluate the magnitude of a phenomenological beta corresponding to the resistance decay parameter across the barrier; these data show that the magnitude of this beta value is modulated via porphyrin macrocycle central metal atom substitution [beta(PZn(n); 0.065 A(-1)) < beta(PCu(n); 0.132 A(-1)) < beta(PNi(n); 0.176 A(-1))]. beta(pzn 344-352 serpin family E member 2 Homo sapiens 411-414 26829704-3 2016 Device resistance measurements, determined as a function of PM(n) molecular length, were utilized to evaluate the magnitude of a phenomenological beta corresponding to the resistance decay parameter across the barrier; these data show that the magnitude of this beta value is modulated via porphyrin macrocycle central metal atom substitution [beta(PZn(n); 0.065 A(-1)) < beta(PCu(n); 0.132 A(-1)) < beta(PNi(n); 0.176 A(-1))]. (2-benzoylethyl)trimethylammonium 146-150 serpin family E member 2 Homo sapiens 411-414 27067684-6 2016 PNI could contribute to adequate patient selection and the improvement of nab-PTX therapy efficacy ingastric cancer. nab 74-77 serpin family E member 2 Homo sapiens 0-3 27067684-6 2016 PNI could contribute to adequate patient selection and the improvement of nab-PTX therapy efficacy ingastric cancer. ptx 78-81 serpin family E member 2 Homo sapiens 0-3 26711710-5 2016 In the case of pN1, the recurrence rate was 14% with SA, 32% with RT, and 33% with RCT (P = .156); and in pN2+, 60%, 49%, and 29%, respectively (P = .012). sa 53-55 serpin family E member 2 Homo sapiens 15-18 26809311-1 2015 A patient in his 70s was diagnosed with rectal cancer (pT3, pN1, cM0, and pStage IIIa) for which he underwent low anterior resection of the rectum and received adjuvant therapy with UFT/LV. uft/lv 182-188 serpin family E member 2 Homo sapiens 60-63 26465957-3 2015 The severity of PNI was evaluated by counting the number of PNIs in all sections with PDAC. pdac 86-90 serpin family E member 2 Homo sapiens 16-19 26465957-8 2015 CONCLUSIONS: The severity of PNI evaluated by counting the number of PNIs in resected specimens was useful for predicting the prognosis of patients with resectable PDAC. pdac 164-168 serpin family E member 2 Homo sapiens 29-32 26987923-3 2015 Here we described the generation of human induced pluripotent stem cell lines (PN1 and PN2) from the peripheral blood of a 1-year-old patient using the dox-inducible STEMCCA vector. Doxorubicin 152-155 serpin family E member 2 Homo sapiens 79-82 25942394-7 2015 RESULTS: According to the 7th edition of the pathological N classification, the 3-year disease-specific survival (DSS) rates for patients with pN1, pN2, and pN3 disease are 89.6%, 65.9%, and 33.6%, respectively (P(N1-N2)=0.030, P(N2-N3)<0.001, P<0.001). dss 114-117 serpin family E member 2 Homo sapiens 143-146 25942394-8 2015 Under the modified pathological N category criteria, the 3-year DSS rates for pN1, pN2, and pN3 patients were 90.7%, 60.5%, and 31.4%, respectively (P(N1-N2)=0.005, P(N2-N3)=0.004, P<0.001). dss 64-67 serpin family E member 2 Homo sapiens 78-81 25480875-17 2015 ALN-RT is often indicated in pN1 patients, particularly in the case of ECE. aln-rt 0-6 serpin family E member 2 Homo sapiens 29-32 24939624-7 2014 Preoperative high FDG uptake in primary tumors was associated with nodal metastases (pN1; Spearman correlation 0.39, p = 0.01). Fluorodeoxyglucose F18 18-21 serpin family E member 2 Homo sapiens 85-88 25199049-10 2014 Overexpression of PN-1 lacking either its antiprotease activity or its binding capacity to glycosaminoglycans had no effect on fibronectin expression. Glycosaminoglycans 91-109 serpin family E member 2 Homo sapiens 18-22 24449194-5 2014 The Kaplan-Meier analysis demonstrated that patients with pN2 and pN1 had a significantly worse DSS compared with patients with pN0 tumors (respectively, 17.273 +- 1.020 and 27.145 +- 1.715 vs. 34.992 +- 2.143 months; P < 0.001). dss 96-99 serpin family E member 2 Homo sapiens 66-69 24212239-8 2014 In patients with CPV, the 5-year survival rate was 56% for patients with no LN metastasis and 44% and 0% for patients with pN1 disease but without extracapsular LN involvement and patients with pN1 disease with extracapsular LN involvement of at least 1 LN, respectively (P = 0.006). Cyclopropavir 17-20 serpin family E member 2 Homo sapiens 194-197 22618708-6 2012 To address these issues, we determined the crystal structures of PN1 in complex with heparin, and in complex with catalytically inert thrombin. Heparin 85-92 serpin family E member 2 Homo sapiens 65-68 23546531-5 2013 The 5-year disease-specific survival (DSS) was worse for pN1 patients than for pN0 patients (46 vs. 77 %; P < 0.0001). dss 38-41 serpin family E member 2 Homo sapiens 57-60 23546531-9 2013 Among pN1 patients, a LN count >12 was associated with a significantly better 5-year DSS (59 vs. 22 %; P = 0.027). dss 88-91 serpin family E member 2 Homo sapiens 6-9 22809039-12 2013 Accurate prediction of the individual risk of CSS may help risk stratifying pN1 UCB in order to help improve clinical-decision making. thiocysteine 46-49 serpin family E member 2 Homo sapiens 76-79 23814118-8 2013 CONCLUSIONS: These results demonstrate that epigenetically regulated PN-1 overexpression promotes development of an antiproteolytic VSMC phenotype and might favor progressive aneurysmal dilation, whereas absence of this counter-regulation in dissections would lead to acute wall rupture. vsmc 132-136 serpin family E member 2 Homo sapiens 69-73 24023701-13 2013 High SERPINE2 levels impair these processes, probably by decreasing cumulus matrix gene expression as well as reducing cumulus hyaluronan contents and inhibiting PLAU activity. Hyaluronic Acid 127-137 serpin family E member 2 Homo sapiens 5-13 22772064-7 2012 In 69 patients MTV and TLG were significantly higher (p=0.0006 and p=0.03) in pN1 patients in comparison to pN0 patients, while SUV values did not show significant differences between the two groups. mtv 15-18 serpin family E member 2 Homo sapiens 78-81 22772064-7 2012 In 69 patients MTV and TLG were significantly higher (p=0.0006 and p=0.03) in pN1 patients in comparison to pN0 patients, while SUV values did not show significant differences between the two groups. (5r)-3-Acetyl-4-Hydroxy-5-Methyl-5-[(1z)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One 23-26 serpin family E member 2 Homo sapiens 78-81 22618708-0 2012 Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism. Heparin 55-62 serpin family E member 2 Homo sapiens 22-38 22618708-3 2012 Rather, PN1 is expressed by multiple cell types, including macrophages, smooth muscle cells, and platelets, and it is on the surface of these cells, bound to glycosaminoglycans, that PN1 inhibits the signaling functions of thrombin. Glycosaminoglycans 158-176 serpin family E member 2 Homo sapiens 8-11 22618708-3 2012 Rather, PN1 is expressed by multiple cell types, including macrophages, smooth muscle cells, and platelets, and it is on the surface of these cells, bound to glycosaminoglycans, that PN1 inhibits the signaling functions of thrombin. Glycosaminoglycans 158-176 serpin family E member 2 Homo sapiens 183-186 23482841-2 2011 METHODS: Working with 5 human cell lines, we determined the CpG methylation status within two CpG islands in the SERPINE2 gene by bisulphate sequencing and the PN-1 mRNA level by Q-RT PCR. bisulphate 130-140 serpin family E member 2 Homo sapiens 113-121 20951508-9 2012 Univariate analysis in the MB cohort revealed that nodal positivity (pN1 vs. pN0) was related to TTLF (hazard ratio 6.39, p = 0.02). ttlf 97-101 serpin family E member 2 Homo sapiens 69-72 21436250-10 2011 The expression quantitative trait loci revealed that five SNPs associated with asthma in CAMP/Illumina and one SNP associated with FEV(1) in CAMP are strongly correlated with SERPINE2 expression levels. Cyclic AMP 89-93 serpin family E member 2 Homo sapiens 175-183 21436250-10 2011 The expression quantitative trait loci revealed that five SNPs associated with asthma in CAMP/Illumina and one SNP associated with FEV(1) in CAMP are strongly correlated with SERPINE2 expression levels. Cyclic AMP 141-145 serpin family E member 2 Homo sapiens 175-183 21761837-1 2011 The synthesis and photophysics of a new Re(I)-carbonyl diimine complex, Re(PNI-phen)(CO)(3)Cl, where the PNI-phen is N-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide is reported. (i)-carbonyl diimine 42-62 serpin family E member 2 Homo sapiens 75-78 21761837-1 2011 The synthesis and photophysics of a new Re(I)-carbonyl diimine complex, Re(PNI-phen)(CO)(3)Cl, where the PNI-phen is N-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide is reported. (i)-carbonyl diimine 42-62 serpin family E member 2 Homo sapiens 105-108 21761837-1 2011 The synthesis and photophysics of a new Re(I)-carbonyl diimine complex, Re(PNI-phen)(CO)(3)Cl, where the PNI-phen is N-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide is reported. n-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide 117-187 serpin family E member 2 Homo sapiens 75-78 21761837-1 2011 The synthesis and photophysics of a new Re(I)-carbonyl diimine complex, Re(PNI-phen)(CO)(3)Cl, where the PNI-phen is N-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide is reported. n-(1,10-phenanthroline)-4-(1-piperidinyl)naphthalene-1,8-dicarboximide 117-187 serpin family E member 2 Homo sapiens 105-108 21761837-2 2011 The metal-to-ligand charge transfer (MLCT) emission lifetime was increased approximately 3000-fold at room temperature with respect to that of the model complex [Re(phen)(CO)(3)Cl] as a result of thermal equilibrium between the emissive (3)MLCT state and a long-lived triplet ligand-centered ((3)LC) state on the PNI chromophore. Metals 4-9 serpin family E member 2 Homo sapiens 313-316 21761837-2 2011 The metal-to-ligand charge transfer (MLCT) emission lifetime was increased approximately 3000-fold at room temperature with respect to that of the model complex [Re(phen)(CO)(3)Cl] as a result of thermal equilibrium between the emissive (3)MLCT state and a long-lived triplet ligand-centered ((3)LC) state on the PNI chromophore. re(phen) 162-170 serpin family E member 2 Homo sapiens 313-316 21761837-2 2011 The metal-to-ligand charge transfer (MLCT) emission lifetime was increased approximately 3000-fold at room temperature with respect to that of the model complex [Re(phen)(CO)(3)Cl] as a result of thermal equilibrium between the emissive (3)MLCT state and a long-lived triplet ligand-centered ((3)LC) state on the PNI chromophore. co)(3)cl 171-179 serpin family E member 2 Homo sapiens 313-316 21858659-8 2011 These findings were validated by analyzing a nationwide registry of 15,488 node-positive patients, which showed that patients with pN1 and intermediate LNR risk had poorer DFS (HR 1.7, 95% CI 1.4-2.2) and CSS (HR 1.6, 95% CI 1.1-2.2) than patients with pN2 and low LNR risk. thiocysteine 205-208 serpin family E member 2 Homo sapiens 131-134 23482841-7 2011 Inhibition of CpG methylation with 5-aza-2"-deoxycytidine led to a several fold increase in PN-1 mRNA levels, but based on the results on CpG methylation in the CpG island spanning the transcript, the effect is most likely indirect. Decitabine 35-57 serpin family E member 2 Homo sapiens 92-96 18393525-1 2008 A new nanoenzyme model with glutathione peroxidase-like active site was constructed on polystyrene nanoparticle (PN1) via microemulsion polymerization. Polystyrenes 87-98 serpin family E member 2 Homo sapiens 113-116 20535627-8 2010 Aldosterone and transforming growth factor-beta1 reciprocally regulate expression of prostasin, PN-1, and ENaC in renal epithelial cell, resulting in sodium retention or natriuresis, respectively. Sodium 150-156 serpin family E member 2 Homo sapiens 96-100 18684774-10 2008 Our results disclose that the prehatching exposure to MeHg induced motor impairments, which were correlated to histological damage and alterations on the cerebellar GSH system"s development from PN 1 to PN 5. mehg 54-58 serpin family E member 2 Homo sapiens 195-199 18684774-10 2008 Our results disclose that the prehatching exposure to MeHg induced motor impairments, which were correlated to histological damage and alterations on the cerebellar GSH system"s development from PN 1 to PN 5. Glutathione 165-168 serpin family E member 2 Homo sapiens 195-199 20942929-6 2010 3- RNAi directed against serpinE2 in caMEK-transformed rat IECs or in human CRC cell lines HCT116 and LoVo markedly decreased foci formation, anchorage-independent growth in soft agarose, cell migration and tumor formation in nude mice. Sepharose 179-186 serpin family E member 2 Homo sapiens 25-33 20564402-7 2010 In the 144 patients with pT2-pT4 and/or pN1-pN3 disease who are suitable to receive CBCC, these proportions were 40% and 24%, respectively (P = .009). Cyclobutanecarbonylcarnitine 84-88 serpin family E member 2 Homo sapiens 40-43 19017876-8 2009 In probands from the Boston Early-Onset COPD Study, SNPs in EPHX1 and in SERPINE2 were associated with the requirement for supplemental oxygen. Oxygen 136-142 serpin family E member 2 Homo sapiens 73-81 17854170-1 2007 Alkynylamidinium groups have been introduced at the beta and meso positions of a nickel(II) porphyrin (PNi(II)) framework. alkynylamidinium 0-16 serpin family E member 2 Homo sapiens 103-106 17854170-1 2007 Alkynylamidinium groups have been introduced at the beta and meso positions of a nickel(II) porphyrin (PNi(II)) framework. nickel(ii) porphyrin 81-101 serpin family E member 2 Homo sapiens 103-106 17854170-5 2007 Analysis of UV-visible absorption profiles for the beta- and meso-alkynylamidinium PNi(II) upon deprotonation enables accurate determination of the amidinium acidity constants for the ground state (pK(a)(beta) = 7.03 +/- 0.1, pK(a)(meso) = 7.74 +/- 0.1 in CH(3)CN) and excited state (pK(a)*(beta) = 6.89 +/- 0.1, pK(a)*(meso) = 8.37 +/- 0.1 in CH(3)CN) porphyrins. amidinium 73-82 serpin family E member 2 Homo sapiens 83-86 17854170-5 2007 Analysis of UV-visible absorption profiles for the beta- and meso-alkynylamidinium PNi(II) upon deprotonation enables accurate determination of the amidinium acidity constants for the ground state (pK(a)(beta) = 7.03 +/- 0.1, pK(a)(meso) = 7.74 +/- 0.1 in CH(3)CN) and excited state (pK(a)*(beta) = 6.89 +/- 0.1, pK(a)*(meso) = 8.37 +/- 0.1 in CH(3)CN) porphyrins. meso 61-65 serpin family E member 2 Homo sapiens 83-86 17970075-5 2007 TIN was higher in colon, pN1/pN2, stage III and IV, and well- or moderately-differentiated adenocarcinoma than in rectum, pNO, stage I and II, and poorly-differentiated or mucinous adenocarcinoma, respectively. Tin 0-3 serpin family E member 2 Homo sapiens 25-28 17854170-5 2007 Analysis of UV-visible absorption profiles for the beta- and meso-alkynylamidinium PNi(II) upon deprotonation enables accurate determination of the amidinium acidity constants for the ground state (pK(a)(beta) = 7.03 +/- 0.1, pK(a)(meso) = 7.74 +/- 0.1 in CH(3)CN) and excited state (pK(a)*(beta) = 6.89 +/- 0.1, pK(a)*(meso) = 8.37 +/- 0.1 in CH(3)CN) porphyrins. meso 232-236 serpin family E member 2 Homo sapiens 83-86 17379830-4 2007 PN-1 bound to the cell surface through interactions with glycosaminoglycans, is an efficient inhibitor of thrombin and controls thrombin-induced cell responses. Glycosaminoglycans 57-75 serpin family E member 2 Homo sapiens 0-4 17379830-8 2007 Pretreatment of the cells with chondroitinase ABC greatly decreased the amount of the PN-1 associated to TM at the cell surface demonstrating the involvement of the TM chondroitin-sulfate chain in the formation of complexes. Chondroitin Sulfates 168-187 serpin family E member 2 Homo sapiens 86-90 12419434-6 2002 Seventeen patients who presented with pT4 or pN1 and/or pM1 received 5-fluorouracil-based chemotherapy postoperatively. Fluorouracil 69-83 serpin family E member 2 Homo sapiens 45-48 17011203-5 2007 Exposure to testosterone or its metabolites (estrogen or dihydrotestosterone) during PN0-2 in females or males castrated at PN0 was sufficient to produce proconvulsant muscimol effects but did not affect the in vitro GABA responses, which remained hyperpolarizing. Testosterone 12-24 serpin family E member 2 Homo sapiens 85-90 17011203-5 2007 Exposure to testosterone or its metabolites (estrogen or dihydrotestosterone) during PN0-2 in females or males castrated at PN0 was sufficient to produce proconvulsant muscimol effects but did not affect the in vitro GABA responses, which remained hyperpolarizing. Dihydrotestosterone 57-76 serpin family E member 2 Homo sapiens 85-90 16420559-6 2006 Overexpression of PN-1 was observed to inhibit thrombin-induced cell responses as indicated by a twofold decrease in induction of PAI-1 expression, a decreased calcium mobilization in response to low thrombin concentrations and a twofold increase in the capacity to inhibit thrombin catalytic activity. Calcium 160-167 serpin family E member 2 Homo sapiens 18-22 16493483-0 2006 Modulation of protease nexin-1 activity by polysaccharides. Polysaccharides 43-58 serpin family E member 2 Homo sapiens 14-30 16493483-4 2006 The purpose of this study was to compare the effects of low (LMW) or high molecular weight (HMW) fucoidans to those of standard heparin and LMW heparin on PN-1 properties. Heparin 144-151 serpin family E member 2 Homo sapiens 155-159 16493483-5 2006 Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and affinity coelectrophoresis, we observed that polysaccharides bound to thrombin, PN-1 and the thrombin/PN-1 complex. Polysaccharides 148-163 serpin family E member 2 Homo sapiens 205-209 16493483-7 2006 Moreover, the formation of PN-1/(125)I-thrombin complex was increased in the presence of heparin, HMW and LMW fucoidans, but barely by LMW heparin. Heparin 89-96 serpin family E member 2 Homo sapiens 27-31 16493483-7 2006 Moreover, the formation of PN-1/(125)I-thrombin complex was increased in the presence of heparin, HMW and LMW fucoidans, but barely by LMW heparin. Heparin, Low-Molecular-Weight 135-146 serpin family E member 2 Homo sapiens 27-31 16493483-9 2006 We also investigated the ability of polysaccharides to remove PN-1 bound to the cell membrane of smooth muscle cells in culture. Polysaccharides 36-51 serpin family E member 2 Homo sapiens 62-66 16493483-10 2006 PN-1 was detached by fucoidans and heparins and was still able to inhibit thrombin. Heparin 35-43 serpin family E member 2 Homo sapiens 0-4 17406311-5 2006 The protocol is based on the use of a recently developed pN1p beta actin-rtTA2S-M2-IRES-EGFP vector (where IRES is an internal ribosome entry site) and permits relatively inexpensive construction of many Tet-on clones with essentially 100% efficiency. tetramethylenedisulfotetramine 204-207 serpin family E member 2 Homo sapiens 57-61 15805872-12 2005 Occult neck disease in N0 patients was low with 4% pN1 for ASG, OC, and LX and with 11% pN1 for OP and HP. N-Acetylgalactosamine 4-sulphate 59-62 serpin family E member 2 Homo sapiens 51-54 16319172-7 2006 Overexpression of PN-1 in CgA-deficient 6T3 cells prevented degradation of DCG proteins at the Golgi apparatus, enhanced DCG biogenesis, and recovered regulated secretion. dcg 75-78 serpin family E member 2 Homo sapiens 18-22 15790463-2 2005 CASE: A 56-year-old Japanese woman diagnosed as having pT2c pN1 M0 pure-type ovarian squamous cell carcinoma was treated with combination chemotherapy consisting of paclitaxel and carboplatin every 3 weeks. Paclitaxel 165-175 serpin family E member 2 Homo sapiens 60-63 15756440-4 2005 A significantly better outcome in the low-dose CDDP/5-FU group than in the surgery alone group was associated with pStage III disease (p<0.001), pN1 lymph node metastasis (p<0.001), and lymphatic invasion (p<0.01). Cisplatin 47-51 serpin family E member 2 Homo sapiens 148-151 15756440-4 2005 A significantly better outcome in the low-dose CDDP/5-FU group than in the surgery alone group was associated with pStage III disease (p<0.001), pN1 lymph node metastasis (p<0.001), and lymphatic invasion (p<0.01). Fluorouracil 52-56 serpin family E member 2 Homo sapiens 148-151 14754568-7 2004 Although CPF exposure on GD17-20, PN1-4, or PN11-14 altered the ability of 5HT to modulate adenylyl cyclase, this change did not correspond with the effects on 5HT receptors, suggesting an additional set of effects on proteins that transduce the 5HT signal. Serotonin 75-78 serpin family E member 2 Homo sapiens 34-39 12949985-9 2003 CONCLUSIONS: Our results suggest that the results of the conventional MTT assay may be useful in evaluating the optimum adjuvant chemotherapy for patients with regional lymph node positive (pN1) esophageal squamous cell carcinoma. monooxyethylene trimethylolpropane tristearate 70-73 serpin family E member 2 Homo sapiens 190-193 12656637-1 2003 Peroxynitric acid/peroxynitrate (PNA) rivals peroxynitrous acid/peroxynitrite (PNI) in importance as a reactive oxygen species. peroxynitric acid 0-17 serpin family E member 2 Homo sapiens 79-82 12656637-1 2003 Peroxynitric acid/peroxynitrate (PNA) rivals peroxynitrous acid/peroxynitrite (PNI) in importance as a reactive oxygen species. Peroxynitrous Acid 18-31 serpin family E member 2 Homo sapiens 79-82 12656637-1 2003 Peroxynitric acid/peroxynitrate (PNA) rivals peroxynitrous acid/peroxynitrite (PNI) in importance as a reactive oxygen species. pna 33-36 serpin family E member 2 Homo sapiens 79-82 12656637-1 2003 Peroxynitric acid/peroxynitrate (PNA) rivals peroxynitrous acid/peroxynitrite (PNI) in importance as a reactive oxygen species. peroxynitrous acid/peroxynitrite 45-77 serpin family E member 2 Homo sapiens 79-82 12656637-1 2003 Peroxynitric acid/peroxynitrate (PNA) rivals peroxynitrous acid/peroxynitrite (PNI) in importance as a reactive oxygen species. Reactive Oxygen Species 103-126 serpin family E member 2 Homo sapiens 79-82 12656637-3 2003 On the other hand, stark differences exist in the stability of these molecules as a function of pH and in the presence of CO(2), and also in the types of bond homolysis reactions that PNA and PNI may undergo. co(2) 122-127 serpin family E member 2 Homo sapiens 192-195 12656637-9 2003 The fundamental principle underlying the large differences in O-O BDEs between PNA and PNI species is that the NO(2) that is formed from PNI can relax from the (2)B(2) excited state to the (2)A(1) ground state, whereas no such comparable state change occurs with NO(3) from PNA. o-o bdes 62-70 serpin family E member 2 Homo sapiens 87-90 12656637-9 2003 The fundamental principle underlying the large differences in O-O BDEs between PNA and PNI species is that the NO(2) that is formed from PNI can relax from the (2)B(2) excited state to the (2)A(1) ground state, whereas no such comparable state change occurs with NO(3) from PNA. o-o bdes 62-70 serpin family E member 2 Homo sapiens 137-140 14527872-1 2003 Nociceptive transduction in inflammatory and neuropathic pain involves peripherally expressed voltage-gated sodium channels, such as tetrodotoxin (TTX)-sensitive PN1 and TTX-resistant PN3. Tetrodotoxin 133-145 serpin family E member 2 Homo sapiens 162-165 14527872-1 2003 Nociceptive transduction in inflammatory and neuropathic pain involves peripherally expressed voltage-gated sodium channels, such as tetrodotoxin (TTX)-sensitive PN1 and TTX-resistant PN3. Tetrodotoxin 147-150 serpin family E member 2 Homo sapiens 162-165 14527872-4 2003 The recombinant human PN1 currents exhibited rapid activation and inactivation kinetics and were blocked by TTX with a half-maximal inhibitory concentration (IC50) of 32.6 nM. Tetrodotoxin 108-111 serpin family E member 2 Homo sapiens 22-25 14527872-8 2003 Lidocaine and mexiletine exhibited tonic and use-dependent block of PN1 and PN3 channels. Lidocaine 0-9 serpin family E member 2 Homo sapiens 68-71 14527872-8 2003 Lidocaine and mexiletine exhibited tonic and use-dependent block of PN1 and PN3 channels. Mexiletine 14-24 serpin family E member 2 Homo sapiens 68-71 14527872-9 2003 The PN1 channel was more susceptible to inhibition by mexiletine than PN3. Mexiletine 54-64 serpin family E member 2 Homo sapiens 4-7 10973954-1 2000 The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor. Heparin 63-70 serpin family E member 2 Homo sapiens 27-43 11876527-1 2002 The aim of the present study was to analyze the effect of serum and human recombinant beta interferon (rIFNbeta) treatment on PN-1 mRNA levels in cultured dermal fibroblasts obtained from the skin of healthy donors and from lesional skin of systemic sclerosis (SSc) patients with the limited (CREST syndrome) or the diffuse form of SSc. rifnbeta 103-111 serpin family E member 2 Homo sapiens 126-130 10973954-3 2000 The inhibitory complexes formed between PN1 and FXIa are stable when subjected to reducing agents, SDS, and boiling, a characteristic of the acyl linkage formed between SERPINs and their cognate proteases. Sodium Dodecyl Sulfate 99-102 serpin family E member 2 Homo sapiens 40-43 10973954-4 2000 Using a sensitive fluorescence-quenched peptide substrate, the K(assoc) of PN1 for FXIa was determined to be 7.9 x 10(4) m(-)(1) s(-)(1) in the absence of heparin. Heparin 155-162 serpin family E member 2 Homo sapiens 75-78 10973954-5 2000 In the presence of heparin, this rate was accelerated to 1.7 x 10(6), M(-)(1) s(-)(1), making PN1 a far better inhibitor of FXIa than C1 inhibitor, which is the only other SERPIN known to significantly inhibit FXIa. Heparin 19-26 serpin family E member 2 Homo sapiens 94-97 10867020-2 2000 We have previously described thrombin (Th)-protease nexin 1 (PN1) inhibitory complex binding to cell surface heparins and subsequent low density lipid receptor-related protein (LRP)-mediated internalization. Heparin 109-117 serpin family E member 2 Homo sapiens 61-64 11016473-5 2000 Gastric cancer patients without LN metastases (pTx pN0; n=78) and patients with LN metastases only in perigastric lymph nodes (pTx pN1; n=34) showed a significantly better long-term prognosis when SLA was performed (84% vs 51%; P=0.001). ptx 127-130 serpin family E member 2 Homo sapiens 131-134 10867020-10 2000 By examining the pH dependence of complex binding in the range of 4.0-7.0, it was determined that the uPA.PN1 inhibitory complexes must specifically bind to endosomal heparins at pH 5.5 to be retained and sorted to lysosomes. Heparin 167-175 serpin family E member 2 Homo sapiens 106-109 9822722-5 1998 TTX-sensitive (TTX-S) currents in small DRG neurons also have slow closed-state inactivation, suggesting that hNE/PN1 contributes to this TTX-S current. Tetrodotoxin 0-3 serpin family E member 2 Homo sapiens 114-117 9822722-5 1998 TTX-sensitive (TTX-S) currents in small DRG neurons also have slow closed-state inactivation, suggesting that hNE/PN1 contributes to this TTX-S current. ttx-s 15-20 serpin family E member 2 Homo sapiens 114-117 9822722-5 1998 TTX-sensitive (TTX-S) currents in small DRG neurons also have slow closed-state inactivation, suggesting that hNE/PN1 contributes to this TTX-S current. ttx-s 138-143 serpin family E member 2 Homo sapiens 114-117 9360977-0 1997 The efficient catabolism of thrombin-protease nexin 1 complexes is a synergistic mechanism that requires both the LDL receptor-related protein and cell surface heparins. Heparin 160-168 serpin family E member 2 Homo sapiens 37-53 9813026-4 1998 A small effect was seen for PN1/heparin inhibition of the exosite-I mutants R35Q, R67Q, R73Q, R75Q, and R77(a)Q, where kon values were decreased 2-4-fold, compared with rIIa. Heparin 32-39 serpin family E member 2 Homo sapiens 28-31 9813026-9 1998 PN1 bound to heparin uses exosite-I to some extent, possibly by utilizing the positive electrostatic field of exosite-I to enhance orientation and thrombin complex formation. Heparin 13-20 serpin family E member 2 Homo sapiens 0-3 9813026-9 1998 PN1 bound to heparin uses exosite-I to some extent, possibly by utilizing the positive electrostatic field of exosite-I to enhance orientation and thrombin complex formation. Iodine 33-35 serpin family E member 2 Homo sapiens 0-3 9813026-9 1998 PN1 bound to heparin uses exosite-I to some extent, possibly by utilizing the positive electrostatic field of exosite-I to enhance orientation and thrombin complex formation. exosite-i 26-35 serpin family E member 2 Homo sapiens 0-3 9360977-5 1997 Since Th-PN1 complexes retain a high-affinity for heparin after complex formation, unlike several of the other SERPINs, we tested the possibility that cell surface heparins were involved in initial complex binding. Heparin 50-57 serpin family E member 2 Homo sapiens 9-12 9360977-6 1997 Soluble heparin was found to be a potent inhibitor of the binding of Th-PN1 to the cell surface and greatly facilitated the dissociation of Th-PN1 complexes pre-bound in the absence of soluble heparin. Heparin 8-15 serpin family E member 2 Homo sapiens 72-75 9360977-6 1997 Soluble heparin was found to be a potent inhibitor of the binding of Th-PN1 to the cell surface and greatly facilitated the dissociation of Th-PN1 complexes pre-bound in the absence of soluble heparin. Heparin 8-15 serpin family E member 2 Homo sapiens 143-146 9360977-9 1997 These data demonstrate the sizable contribution of cell surface heparins to Thrombin-PN1 complex binding and support a model in which these heparins act to concentrate the complexes at the cell surface facilitating their subsequent LRP-dependent endocytosis. Heparin 64-72 serpin family E member 2 Homo sapiens 85-88 7506041-10 1993 Northern blot analysis of U138 RNA demonstrated positive hybridization with an oligodeoxynucleotide specific for PN-1. Oligodeoxyribonucleotides 79-99 serpin family E member 2 Homo sapiens 113-117 8549675-6 1996 We detected specific SDS-stable PNI/thrombin complexes in myotube extracts only, indicating that active PNI was bound to their surfaces. Sodium Dodecyl Sulfate 21-24 serpin family E member 2 Homo sapiens 32-35 8549675-6 1996 We detected specific SDS-stable PNI/thrombin complexes in myotube extracts only, indicating that active PNI was bound to their surfaces. Sodium Dodecyl Sulfate 21-24 serpin family E member 2 Homo sapiens 104-107 7670362-0 1995 Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals. Free Radicals 61-74 serpin family E member 2 Homo sapiens 16-32 8940166-8 1996 Brefeldin A, an inhibitor of vesicular traffic, inhibited both basal and mastoparan-stimulated PN-1 secretions. Brefeldin A 0-11 serpin family E member 2 Homo sapiens 95-99 8738754-7 1996 We now report that subnanomolar amounts of PNI enhance neuronal survival in mixed spinal cord cell culture, especially when neuronal cells were made electrically silent by administration of tetrodotoxin. Tetrodotoxin 190-202 serpin family E member 2 Homo sapiens 43-46 8923453-2 1996 A strong negative regulatory element has been shown by the missing nucleoside technique to be a CACGTG site (E-box) in the proximal part of the PN-1 promoter. Nucleosides 67-77 serpin family E member 2 Homo sapiens 144-148 8923453-2 1996 A strong negative regulatory element has been shown by the missing nucleoside technique to be a CACGTG site (E-box) in the proximal part of the PN-1 promoter. cacgtg 96-102 serpin family E member 2 Homo sapiens 144-148 8006028-7 1994 These studies showed that collagen type IV decreased the formation of SDS-stable complexes between urokinase or plasmin and PN-1 without affecting formation of complexes between thrombin and PN-1. Sodium Dodecyl Sulfate 70-73 serpin family E member 2 Homo sapiens 124-128 8216224-11 1993 for protease nexin I, protein C inhibitor and antithrombin III showed a bell-shaped dependence on heparin concentration. Heparin 98-105 serpin family E member 2 Homo sapiens 4-20 8216224-12 1993 At optimal concentrations, heparin accelerated the rate of inhibition by protease nexin I, protein C inhibitor and antithrombin III by 44-, 18- and 13-fold respectively. Heparin 27-34 serpin family E member 2 Homo sapiens 73-89 8360185-7 1993 Treatment of cells with both cycloheximide and IL-1 reduced the levels of PN-1 mRNA. Cycloheximide 29-42 serpin family E member 2 Homo sapiens 74-78 8360185-9 1993 However, experiments with actinomycin D demonstrated that IL-1 significantly increased the half-life of the PN-1 mRNA. Dactinomycin 26-39 serpin family E member 2 Homo sapiens 108-112 8360185-10 1993 In contrast, dexamethasone (DXM) repressed the synthesis and secretion of PN-1 from fibroblasts. Dexamethasone 13-26 serpin family E member 2 Homo sapiens 74-78 8360185-10 1993 In contrast, dexamethasone (DXM) repressed the synthesis and secretion of PN-1 from fibroblasts. Dexamethasone 28-31 serpin family E member 2 Homo sapiens 74-78 8360185-12 1993 A sustained decrease in PN-1 mRNA was also seen when cells were treated with cycloheximide and DXM. Cycloheximide 77-90 serpin family E member 2 Homo sapiens 24-28 8360185-12 1993 A sustained decrease in PN-1 mRNA was also seen when cells were treated with cycloheximide and DXM. Dexamethasone 95-98 serpin family E member 2 Homo sapiens 24-28 8360185-13 1993 In nuclear run-on assays, DXM functioned as a transcriptional repressor of PN-1 synthesis. Dexamethasone 26-29 serpin family E member 2 Homo sapiens 75-79 8360185-16 1993 While DXM directly regulates PN-1 at the level of transcription, IL-1 in the presence of ongoing protein synthesis regulates PN-1 production predominantly in a post-transcriptional fashion by increasing the half-life of the PN-1 mRNA. Dexamethasone 6-9 serpin family E member 2 Homo sapiens 29-33