PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33453127-10	2021	Furthermore, artemisinin restored LPS-induced decrease of junction proteins ZO-1, Occludin and Claudin-5 in primary brain microvessel endothelial cells, and attenuated LPS-induced blood brain barrier disruption in mice as assessed by Evans blue.	artemisinin	13-24	claudin 5	Mus musculus	95-104
33674828-14	2021	However, atorvastatin treatment could protect the BBB integrity from the impact of surgery, by up-regulating the expressions of ZO-1, occludin, and Claudin 5.	Atorvastatin	9-21	claudin 5	Mus musculus	148-157
33613705-9	2021	Furthermore, treatment with 4-MA upregulated the expression of occludin, claudin-5, Akt and eNOS, in addition to increasing eNOS and AKT phosphorylation in bEnd.3 cells.	anisyl alcohol	28-32	claudin 5	Mus musculus	73-82
33839700-10	2021	The expression level of down-regulated claudin-5 in the cerebral cortex of MCAO mice was significantly suppressed by Agomelatine.	agomelatine	117-128	claudin 5	Mus musculus	39-48
33839700-13	2021	The down-regulated claudin-5 by hypoxic incubation in endothelial cells was up-regulated by treatment with Agomelatine.	agomelatine	107-118	claudin 5	Mus musculus	19-28
33524408-7	2021	Mechanistically, lithium upregulated the activity of endothelial Wnt/beta-catenin signaling in vivo and in vitro, increased the protein levels of tight junctions (Claudin-5 and ZO-1), and reduced MMP-9 expression.	Lithium	17-24	claudin 5	Mus musculus	163-172
33309746-7	2021	Escin ameliorated the increasing levels of RhoA, ROCK1, nuclear NF-kappaB and the decreasing expression of IkappaBalpha, cytosolic NF-kappaB, occludin, claudin-5 in the ICH group.	Escin	0-5	claudin 5	Mus musculus	152-161
33309746-8	2021	IL-1beta administration blocked not only escin-mediated increases of IkappaBalpha, cytosolic NF-kappaB, occludin, and claudin-5, but also escin-caused decreases of RhoA, ROCK1, and nuclear NF-kappaB.	Escin	41-46	claudin 5	Mus musculus	118-127
33430871-9	2021	Western-blot, immunohistochemical analysis and qPCR suggested that gastroprotective properties of lactate were mediated by its modulatory effects on the expression of the apoptosis regulator gene Bax, the apoptotic executive protein gene Casp3, and genes critical for gastric mucosal integrity, including those encoding tight junction proteins Occludin, Claudin-1, Claudin-5, and that for lactate receptor GPR81.	Lactic Acid	98-105	claudin 5	Mus musculus	365-374
33573189-4	2021	High glucose decreased occludin, claudin-5, zona occludens-1 (ZO-1) and zona occludens-2 (ZO-2) tight junctions production and altered the endothelial permeability.	Glucose	5-12	claudin 5	Mus musculus	33-42
33430871-10	2021	CONCLUSION: Lactate mitigates ethanol-induced GMI by curtailing local gastric inflammatory response, down-regulating the expression of the apoptosis regulator and executor genes Bax and Casp3, and up-regulating the expression of genes encoding tight junction proteins Occludin, Claudin-1, and Claudin-5 and the lactate receptor GPR81.	Lactic Acid	12-19	claudin 5	Mus musculus	293-302
33430871-10	2021	CONCLUSION: Lactate mitigates ethanol-induced GMI by curtailing local gastric inflammatory response, down-regulating the expression of the apoptosis regulator and executor genes Bax and Casp3, and up-regulating the expression of genes encoding tight junction proteins Occludin, Claudin-1, and Claudin-5 and the lactate receptor GPR81.	Ethanol	30-37	claudin 5	Mus musculus	293-302
33225820-9	2020	Furthermore, treating cerebral vessels of young mice with mitochondrial N-formyl peptides upregulated IL-6, increased Parkin, and reduced Claudin-5, a tight junction protein integral to BBB integrity.	n-formyl peptides	72-89	claudin 5	Mus musculus	138-147
33237730-6	2020	Importantly, we found that Omarigliptin protected the integrity of the BBB against LPS by increasing the expression of the tight junction proteins claudin-1 and claudin-5.	2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine	27-39	claudin 5	Mus musculus	161-170
33237730-9	2020	Consistently, Omarigliptin ameliorated LPS-induced exacerbation of endothelial permeability by increasing the expressions of claudin-1 and claudin-5 and reducing the expression of MMP-2 and MMP-9.	2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine	14-26	claudin 5	Mus musculus	139-148
32790044-12	2020	Similarly, UK383367 downregulated the expression of GFAP and upregulated the expression of beta-DG, ZO-1, occludin, and claudin-5.	UK 383367	11-19	claudin 5	Mus musculus	120-129
33535331-10	2021	Western blot test results showed that the relative expression levels of Claudin-5 and Syndecan-1 protein in the mice glomeruli of TCE positive group were significantly lower than those in the vehicle control group and TCE negative group (P<0.05) .	Trichloroethylene	130-133	claudin 5	Mus musculus	72-81
33535331-10	2021	Western blot test results showed that the relative expression levels of Claudin-5 and Syndecan-1 protein in the mice glomeruli of TCE positive group were significantly lower than those in the vehicle control group and TCE negative group (P<0.05) .	Trichloroethylene	218-221	claudin 5	Mus musculus	72-81
32891717-15	2020	The strong fluorescence of ZO-1 and claudin-5 were uniformly distributed along the whole epithelial mucosa after KFX-P treatment, indicating the effective repairing of the colonic mucosal barrier.	kfx-p	113-118	claudin 5	Mus musculus	36-45
32916895-7	2020	In addition, well-known antioxidants, trolox and N-acetyl cysteine, significantly attenuated the BBB permeability increase, disruption of claudin-5 and ZO-1, and FoxO3a activation during hypoxia, suggesting that ROS are important mediators of BBB dysfunction during hypoxia.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	38-44	claudin 5	Mus musculus	138-147
33224434-9	2020	VPA administration significantly decreased the expression of phosphorylated nuclear factor-kappa B (p-NFkappaB), matrix metalloproteinases 9 (MMP9), tumor necrosis factoralpha (TNFalpha), and interleukin-6 (IL-6), while it enhanced the expression of claudin 5 and occludin in the brain.	Valproic Acid	0-3	claudin 5	Mus musculus	250-259
33192319-10	2020	Our data show increased claudin-5 and occludin expression in oxygen and glucose (OGD)-deprived murine brain capillary cerebellar endothelial cells (cerebEND) after STVNa treatment.	Oxygen	61-67	claudin 5	Mus musculus	24-33
33192319-10	2020	Our data show increased claudin-5 and occludin expression in oxygen and glucose (OGD)-deprived murine brain capillary cerebellar endothelial cells (cerebEND) after STVNa treatment.	Glucose	72-79	claudin 5	Mus musculus	24-33
32916895-7	2020	In addition, well-known antioxidants, trolox and N-acetyl cysteine, significantly attenuated the BBB permeability increase, disruption of claudin-5 and ZO-1, and FoxO3a activation during hypoxia, suggesting that ROS are important mediators of BBB dysfunction during hypoxia.	Acetylcysteine	49-66	claudin 5	Mus musculus	138-147
32823646-6	2020	AlaGln increased transepithelial resistance, and in CPDF exposed HUVEC decreased dextran transport rates and preserved claudin-5 and ZO-1 abundance.	cpdf	52-56	claudin 5	Mus musculus	119-128
32529968-6	2020	The molecular mechanisms underlying the effects of CsA were explored, and it was found that CsA could inhibit the increase in CypA, p-Akt, NF-kappaB, and MMP-9 protein expression after middle cerebral artery occlusion, while Claudin-5 expression was decreased.	Cyclosporine	92-95	claudin 5	Mus musculus	225-234
32823646-8	2020	In mice, arteriolar endothelial claudin-5 was reduced in CPDF, but restored with AlaGln, while mesothelial claudin-5 abundance was unchanged.	cpdf	57-61	claudin 5	Mus musculus	32-41
32823646-8	2020	In mice, arteriolar endothelial claudin-5 was reduced in CPDF, but restored with AlaGln, while mesothelial claudin-5 abundance was unchanged.	alanylglutamine	81-87	claudin 5	Mus musculus	32-41
32823646-9	2020	AlaGln supplementation seals the peritoneal endothelial barrier, and when supplemented to conventional PD fluid increases claudin-5 and ZO-1 abundance and clustering of ZO-1 in the endothelial cell membrane.	alanylglutamine	0-6	claudin 5	Mus musculus	122-131
31575337-9	2020	Furthermore, ATN-161 treatment reduced IgG extravasation into the parenchyma through conserved claudin-5, collagen IV, CXCL12 while reducing MMP-9 transcription.	ATN-2	13-20	claudin 5	Mus musculus	95-104
32548640-5	2020	An investigation into barrier proteins revealed that heme primarily affects the tight junction proteins, zona occludens-1, claudin-1, and claudin-5, which were significantly reduced after heme exposure.	Heme	53-57	claudin 5	Mus musculus	138-147
32548640-5	2020	An investigation into barrier proteins revealed that heme primarily affects the tight junction proteins, zona occludens-1, claudin-1, and claudin-5, which were significantly reduced after heme exposure.	Heme	188-192	claudin 5	Mus musculus	138-147
32333532-13	2020	CONCLUSION: EA can enhance the effect of Donepezil in improving learning-memory ability in AD mice possibly by regulating expression of MMP-9, LRP-1, Pgp and Claudin-5 mRNAs and strengthening the effect of Donepezil in transporting Abeta via BBB.	Donepezil	41-50	claudin 5	Mus musculus	158-167
32035889-10	2020	Sev decreased the expression of heavy chain ferritin (FtH), light chain ferritin (FtL), MBP, ZO-1, occludin, claudin-5, and FpN1, and increased TfR1 in hippocampus and cortex or cerebral microvascular endothelial cells of offspring mice, indicating that Sev caused the iron deficiency and impaired the myelinogenesis in the brain of offspring.	sevoflurane	0-3	claudin 5	Mus musculus	109-118
32141492-10	2020	In bEnd.3 cells, TDZD-8 treatment reduced TLR4 expression and increased claudin5 expression in cells stimulated with lipopolysaccharides.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	17-23	claudin 5	Mus musculus	72-80
32038167-10	2020	When the pan-caspase inhibitor Z-VAD-fmk was used after HSV-1 infection to inhibit apoptosis, the protein levels of GM130, occludin and claudin 5 were partially restored.	NIR-VAD-fmk	31-40	claudin 5	Mus musculus	136-145
30574832-6	2020	We identified that AKT2 during homeostasis specifically regulates CLDN5-dependent barrier integrity in brain microvascular endothelial cells (BMVECs) and that intervention with a selective insulin-receptor (IR) agonist, demethylasterriquinone B1 (DMAQ-B1), rescued IL-1beta-induced AKT2 inactivation, FOXO1 nuclear accumulation, and loss of CLDN5-dependent barrier integrity.	demethylasterriquinone	220-242	claudin 5	Mus musculus	66-71
30574832-6	2020	We identified that AKT2 during homeostasis specifically regulates CLDN5-dependent barrier integrity in brain microvascular endothelial cells (BMVECs) and that intervention with a selective insulin-receptor (IR) agonist, demethylasterriquinone B1 (DMAQ-B1), rescued IL-1beta-induced AKT2 inactivation, FOXO1 nuclear accumulation, and loss of CLDN5-dependent barrier integrity.	demethylasterriquinone	220-242	claudin 5	Mus musculus	341-346
30574832-7	2020	Moreover, DMAQ-B1 attenuated preclinical CLDN5-dependent BBB dysfunction in mice subjected to experimental autoimmune encephalomyelitis.	dmaq	10-14	claudin 5	Mus musculus	41-46
31706766-6	2020	PFOS significantly decreased the expression of TJ-related proteins (ZO-1, Claudin-5, Claudin-11, Occludin) in endothelial cells and disrupted BBB, which subsequently led PFOS to astrocytes and increased the expression of the proteins related to astrocytic damages (Aquaporin 4 and S100beta).	perfluorooctane sulfonic acid	0-4	claudin 5	Mus musculus	74-83
33268702-3	2020	Still, the therapeutic mechanism of YZFDF in restoring Abeta-induced injury of TJ proteins (ZO-1, Occludin, and Claudin-5) remains unclear.	yzfdf	36-41	claudin 5	Mus musculus	112-121
31760035-5	2020	Here, we first found that NAS administration ameliorated TBI-induced brain edema, blood-brain barrier (BBB) disruption, increase of matrix metalloproteinase-9 (MMP-9) expression and decrease of claudin-5 expression.	N-acetylserotonin	26-29	claudin 5	Mus musculus	194-203
30290210-8	2019	Using the permanent middle cerebral artery occlusion (pMCAO) mouse model, we found JTE013 pretreatment markedly reduced Evans blue dye (EBD) extravasation and reversed the decrease in VE-cadherin, occludin, claudin-5 and CD31 expression in infarcted hemisphere.	JTE 013	83-89	claudin 5	Mus musculus	207-216
30845271-12	2019	The administration of dexamethasone decreased the expressions of BBB junctional proteins occludin and claudin-5 in the mice brain meninges.	Dexamethasone	22-35	claudin 5	Mus musculus	102-111
31391341-5	2019	Persistent suppression of claudin-5 expression in mice exposed to a cholesterol-enriched diet induced striking retinal pigment epithelium (RPE) cell atrophy, and persistent targeted suppression of claudin-5 in the macular region of nonhuman primates induced RPE cell atrophy.	Cholesterol	68-79	claudin 5	Mus musculus	26-35
31391341-5	2019	Persistent suppression of claudin-5 expression in mice exposed to a cholesterol-enriched diet induced striking retinal pigment epithelium (RPE) cell atrophy, and persistent targeted suppression of claudin-5 in the macular region of nonhuman primates induced RPE cell atrophy.	Cholesterol	68-79	claudin 5	Mus musculus	197-206
30548093-10	2019	Meanwhile, cyclopamine blocked the effect of TXL-up-regulated expression of occludin, claudin-5 and ZO-1.	cyclopamine	11-22	claudin 5	Mus musculus	86-95
30548093-10	2019	Meanwhile, cyclopamine blocked the effect of TXL-up-regulated expression of occludin, claudin-5 and ZO-1.	Docetaxel	45-48	claudin 5	Mus musculus	86-95
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	claudin 5	Mus musculus	122-131
30812071-14	2018	The IF and qRT-PCR results showed that the protein and mRNA expression levels of ZO-1, Occludin, and Claudin-5 were significantly reduced with the increase in the concentration of PQ (P&lt;0.05) .	Paraquat	180-182	claudin 5	Mus musculus	101-110
29856989-6	2018	Results have shown that 3-MA partially reversed Abeta1-42 oligo induced downregulation of ZO-1, Occludin and Claudin-5, which was further determined by LC3 siRNA.	3-methyladenine	24-28	claudin 5	Mus musculus	109-118
30622526-9	2018	The MAPK kinase inhibitor p38 diminished the formation of NETs and restored the expression of the tight junction protein claudin-5 in the mouse lung when challenged with poly I:C.	Poly I-C	170-178	claudin 5	Mus musculus	121-130
30225764-5	2018	We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis.	dss	134-137	claudin 5	Mus musculus	87-96
29797543-16	2018	Together, the results suggested that STK may affect the expression of E3 ubiquitin ligase HECTD1 and subsequently increase the degradation of claudin-5, thus enabling SS2 to traverse the BBB.	(R)-1-phenylethanol	167-170	claudin 5	Mus musculus	142-151
30054495-7	2018	Further investigation of delayed (72 hour) BBB disruption revealed that claudin-5 (CLD5) expression was disrupted specifically in the hippocampus, but not in dorsal striatum, a brain region that showed no blast-induced BBB permeability to sucrose or albumin.	Sucrose	239-246	claudin 5	Mus musculus	72-81
30054495-7	2018	Further investigation of delayed (72 hour) BBB disruption revealed that claudin-5 (CLD5) expression was disrupted specifically in the hippocampus, but not in dorsal striatum, a brain region that showed no blast-induced BBB permeability to sucrose or albumin.	Sucrose	239-246	claudin 5	Mus musculus	83-87
30054495-8	2018	In addition, we found that delayed BBB permeability and disrupted CLD5 expression were blocked by the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME).	NG-Nitroarginine Methyl Ester	134-168	claudin 5	Mus musculus	66-70
30054495-8	2018	In addition, we found that delayed BBB permeability and disrupted CLD5 expression were blocked by the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME).	NG-Nitroarginine Methyl Ester	170-176	claudin 5	Mus musculus	66-70
30024618-8	2018	After 8-MOP treatment, the expression of MMP-9 decreased in ischemic brain tissue, whereas the expression of claudin-5, VEGF, and GFAP increased, suggesting that the blood-brain barrier ultrastructure was improved.	Methoxsalen	6-11	claudin 5	Mus musculus	109-118
29107696-11	2018	HSYA could significantly reduce the leakage of Evans Blue in mice with ischemia stroke, while attenuating the expression of occludin, claudin-5, and ZO-1.	hydroxysafflor yellow A	0-4	claudin 5	Mus musculus	134-143
27873103-0	2017	Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8.	Histamine	74-83	claudin 5	Mus musculus	61-70
28545897-5	2017	Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-gamma, interleukin (IL)-5, IL-33, and tumor necrosis factor-alpha levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability.	Resveratrol	10-21	claudin 5	Mus musculus	200-209
28373092-5	2017	In addition, Collagen IV, ZO-1, Occludin and Claudin 5 expressions in ipsilateral/left hemisphere were downregulated after SAH, but increased after CsA treatment.	Cyclosporine	148-151	claudin 5	Mus musculus	45-54
27873103-9	2017	Claudin-5 was shown to be regulated VEGFR2/PI3K-Akt dependently by VEGF and PI3K-Akt independently by histamine.	Histamine	102-111	claudin 5	Mus musculus	0-9
27873103-10	2017	Interleukin-8 was shown to downregulate claudin-5 by histamine.	Histamine	53-62	claudin 5	Mus musculus	40-49
28966265-15	2017	These results suggest that the ETB receptor antagonist BQ788 protects against brain edema by inhibiting VEGF-A-mediated decrease in claudin-5.	BQ 788	55-60	claudin 5	Mus musculus	132-141
26515186-0	2016	Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.	Nitric Oxide	0-12	claudin 5	Mus musculus	81-90
27823626-7	2016	Celastrol induced occludin, claudin-5 and zonula occludens-1 (ZO-1) in endothelial cells.	celastrol	0-9	claudin 5	Mus musculus	28-37
27823626-10	2016	We also observed that celastrol regulated claudin-5 expression through different mechanisms.	celastrol	22-31	claudin 5	Mus musculus	42-51
27535376-8	2016	Resveratrol at doses of 25 and 50 mg/kg produced a dose-dependent decrease in EAE paralysis and EB leakage, ameliorated EAE-induced loss of tight junction proteins ZO-1, occludin, and claudin-5, as well as repressed the EAE-induced increase in adhesion proteins ICAM-1 and VCAM-1.	Resveratrol	0-11	claudin 5	Mus musculus	184-193
26515186-0	2016	Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.	oxygen-glucose	106-120	claudin 5	Mus musculus	81-90
26515186-1	2016	Using in vitro oxygen-glucose deprivation (OGD) model, we have previously demonstrated that 2-h OGD induces rapid, caveolin-1-mediated dissociation of claudin-5 from the cellular cytoskeletal framework and quick endothelial barrier disruption.	oxygen-glucose	15-29	claudin 5	Mus musculus	151-160
27247145-7	2016	In TM4 cells, the expressions of BTB proteins (ZO-1, occludin, claudin-5, and connexin-43) were lower in the ZnO NPs group.	Zinc Oxide	109-112	claudin 5	Mus musculus	63-72
27357536-11	2016	The expression of molecules that protect tight junctions, zonula occluden-1 and claudin-5, was upregulated by lycopene treatment after SCI.	Lycopene	110-118	claudin 5	Mus musculus	80-89
25465237-10	2016	Our results show that METH led to disruption of the actin filaments concomitant with claudin-5 translocation to the cytoplasm.	Methamphetamine	22-26	claudin 5	Mus musculus	85-94
27095710-5	2016	In vitro results showed that cCPEY306W/S313H is able to bind specifically to Cldn5 in murine brain vascular endothelial (bEnd.3) cells, and is transported along with Cldn5 from the cell membrane to the cytoplasm, which in turn results in a reduction in transendothelial electrical resistance (TEER).	ccpey306w	29-38	claudin 5	Mus musculus	77-82
27095710-5	2016	In vitro results showed that cCPEY306W/S313H is able to bind specifically to Cldn5 in murine brain vascular endothelial (bEnd.3) cells, and is transported along with Cldn5 from the cell membrane to the cytoplasm, which in turn results in a reduction in transendothelial electrical resistance (TEER).	ccpey306w	29-38	claudin 5	Mus musculus	166-171
27103568-6	2016	We observed that D-allose remarkably decreased BBB permeability and prevented the reduction of ZO-1, Occludin and Claudin-5 in mice brains with MCAO/Rep injury.	allose	17-25	claudin 5	Mus musculus	114-123
26306919-0	2016	The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5.	perampanel	36-46	claudin 5	Mus musculus	133-142
26306919-7	2016	In addition, the expression of claudin-5 at protein level, but not at mRNA level, was increased by perampanel treatment after OGD.	perampanel	99-109	claudin 5	Mus musculus	31-40
26306919-8	2016	Knockdown of claudin-5 partially prevented perampanel-induced protection in cell viability and BBB integrity in OGD-injured mBECs.	perampanel	43-53	claudin 5	Mus musculus	13-22
26409663-0	2015	Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment.	Steroids	80-87	claudin 5	Mus musculus	0-9
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	btb	34-37	claudin 5	Mus musculus	85-93
26165742-5	2015	We found the expression levels of BTB factors (Connexin43, ZO-1, Vimentin, Claudin1, Claudin5) were disrupted in TM-4 cells after HS treatment, which were recovered by the addition of carnitine.	Carnitine	184-193	claudin 5	Mus musculus	85-93
26274818-6	2015	Comparisons of total brain samples with isolated brain endothelial cells together with the stainings for Pecam-1/CD31 and claudin-5 led to the assumption that the morphology of brain vessels is affected by antenatal dexamethasone treatment at PN4.	Dexamethasone	216-229	claudin 5	Mus musculus	122-131
25986579-11	2015	Furthermore, linagliptin significantly increased cerebral claudin-5 and significantly decreased gp91phox in diabetic mice subjected to transient cerebral ischemia.	Linagliptin	13-24	claudin 5	Mus musculus	58-67
26274818-4	2015	The major findings were that in total brains on postnatal day (PN) 4 triple antenatal dexamethasone treatment significantly downregulated the tight junction protein claudin-5, the endothelial marker Pecam-1/CD31, the glucocorticoid receptor, the NR1 subunit of the N-methyl-D-aspartate receptor, and Abc transporters (Abcb1a, Abcg2 Abcc4).	Dexamethasone	86-99	claudin 5	Mus musculus	165-174
26199634-4	2015	In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice.	Escin	26-31	claudin 5	Mus musculus	160-169
25281324-7	2014	Results showed early reversible loss of sharp paracellular claudin-5 expression 90, 105, and 120 minutes after 3-chloropropanediol (500 muM) treatment.	alpha-Chlorohydrin	111-130	claudin 5	Mus musculus	59-68
25281324-8	2014	Sharp paracellular claudin-5 profiles were later restored, but lost again by 2 and 3 days after 3-chloropropanediol treatment.	alpha-Chlorohydrin	96-115	claudin 5	Mus musculus	19-28
25268765-5	2014	DDS also increased the expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels.	Dapsone	0-3	claudin 5	Mus musculus	99-108
24846172-6	2014	Recently we have cloned and characterized a murine claudin-5 promoter and demonstrated 17beta-estradiol (E2)-mediated regulation of claudin-5 in brain and heart microvascular endothelium on promoter, mRNA and protein level.	Estradiol	87-103	claudin 5	Mus musculus	51-60
24919817-8	2014	Compared with Vehicle group, Evo significantly ameliorated neurological deficit, brain water content and infarct size, upregulated the expression of pAkt, pGSK3beta and claudin-5, and downregulated the nuclear accumulation of NF-kappaB (P &lt; 0.05).	evodiamine	29-32	claudin 5	Mus musculus	169-178
24919817-9	2014	Evo protected the brain from ischemic damage caused by pMCAO; this effect may be through upregulation of pAkt, pGSK3beta and claudin-5, and downregulation of NF-kappaB expression.	evodiamine	0-3	claudin 5	Mus musculus	125-134
24846172-6	2014	Recently we have cloned and characterized a murine claudin-5 promoter and demonstrated 17beta-estradiol (E2)-mediated regulation of claudin-5 in brain and heart microvascular endothelium on promoter, mRNA and protein level.	Estradiol	87-103	claudin 5	Mus musculus	132-141
24028293-0	2014	Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin.	Simvastatin	68-79	claudin 5	Mus musculus	8-17
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	claudin 5	Mus musculus	130-139
24028293-4	2014	These effects were associated with membrane translocation of VE-cadherin, whereas translocation of vascular endothelial cadherin (VE-cadherin; silencing RNA) inhibited simvastatin-induced claudin-5 up-regulation.	Simvastatin	168-179	claudin 5	Mus musculus	188-197
24028293-5	2014	Moreover, simvastatin treatment of ECs induced increased phosphorylation of both FoxO1 and beta-catenin, transcriptional regulators of claudin-5 expression mediated by VE-cadherin.	Simvastatin	10-21	claudin 5	Mus musculus	135-144
24028293-7	2014	However, silencing of claudin-5 did significantly attenuate simvastatin-mediated EC barrier protection in response to thrombin, as measured by monolayer flux of sodium fluorescein (376 Da).	Simvastatin	60-71	claudin 5	Mus musculus	22-31
24028293-7	2014	However, silencing of claudin-5 did significantly attenuate simvastatin-mediated EC barrier protection in response to thrombin, as measured by monolayer flux of sodium fluorescein (376 Da).	Fluorescein	161-179	claudin 5	Mus musculus	22-31
22687898-2	2013	Exposure to nanoalumina, but not to nanocarbon, induced a dose-dependent mitochondrial potential collapse, increased autophagy of brain endothelial cells, and decreased expression of the tight-junction proteins occludin and claudin-5.	nanoalumina	12-23	claudin 5	Mus musculus	224-233
24421076-3	2014	Breaching of the BBB in vivo by TNBCs resulted in increased BBB permeability and changes in ZO-1 and claudin-5 tight junction (TJ) protein structures.	tnbcs	32-37	claudin 5	Mus musculus	101-110
24212132-6	2013	The levels of phospho-Syk, MMP9 and ICAM-1 were downregulated, and the level of Claudin5 was uplegurated in piceatannol-treated groups.	3,3',4,5'-tetrahydroxystilbene	108-119	claudin 5	Mus musculus	80-88
23959874-5	2013	Here, we show that the orally available small molecule LY-317615, a synthetic bisindolylmaleimide and inhibitor of protein kinase Cbeta, which is clinically under investigation for the treatment of cancer, suppresses the transmigration of activated T cells through an inflamed endothelial cell barrier, where it leads to the induction of the tight-junction molecules zona occludens-1, claudin 3, and claudin 5 and other pathways critically involved in transendothelial leukocyte migration.	enzastaurin	55-64	claudin 5	Mus musculus	400-409
24759004-9	2014	Progesterone did not affect the expression of both VE-cadherin and claudin-5 and estradiol-17beta also did not affect the VE-cadherin expression, but estradiol-17beta significantly decreased the claudin-5 expression.	Estradiol	150-166	claudin 5	Mus musculus	195-204
24248858-0	2014	Protective effect of shikonin in experimental ischemic stroke: attenuated TLR4, p-p38MAPK, NF-kappaB, TNF-alpha and MMP-9 expression, up-regulated claudin-5 expression, ameliorated BBB permeability.	shikonin	21-29	claudin 5	Mus musculus	147-156
24248858-8	2014	In addition, shikonin effectively alleviated brain leakage of Evans blue, up-regulated claudin-5 expression, and inhibited the over-expressed MMP-9 in ischemic brain.	shikonin	13-21	claudin 5	Mus musculus	87-96
22120415-3	2013	METHODS: Trospium chloride at 1 mg/kg was intravenously administered to adult, middle-aged, and aged mice at 6, 12, and 24 months of age, respectively, and the absolute drug concentrations in the brain were analysed after 2 h. Furthermore, mRNA expression levels of relevant markers of blood-brain barrier integrity (occludin, claudin-5, and the drug efflux carrier P-glycoprotein) were analysed in brain samples from adult and aged mice.	trospium chloride	9-26	claudin 5	Mus musculus	327-336
22687898-3	2013	Inhibition of autophagy by pretreatment with Wortmannin attenuated the effects of nanoalumina on decreased claudin-5 expression; however, it did not affect the disruption of occludin.	Wortmannin	45-55	claudin 5	Mus musculus	107-116
23505411-6	2013	Degradation of claudin-5 coincided with alteration of the blood-CSF barrier permeability and treatment with the MMP inhibitor GM6001 attenuated the degradation of claudin-5.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	126-132	claudin 5	Mus musculus	163-172
21803344-10	2011	METH was able to decrease the protein levels of zonula occludens (ZO)-1, claudin-5 and occludin in the hippocampus 24h post-injection, and increased the activity and immunoreactivity of MMP-9.	Methamphetamine	0-4	claudin 5	Mus musculus	73-82
21892742-6	2012	Additionally, Y-27632 inhibited BK-induced relocation of occludin and claudin-5 from cellular borders into the cytoplasm as well as stress fiber formation in RBMECs.	Y 27632	14-21	claudin 5	Mus musculus	70-79
21705496-6	2011	Using a murine model of HHcy (cbs(+/-)), treatment for 2 weeks with an NMDAr antagonist (memantine) rescued cerebrovascular expression of claudin-5 and blood-brain barrier permeability to both exogenous sodium fluorescein and endogenous IgG.	Memantine	89-98	claudin 5	Mus musculus	138-147
20333434-4	2010	Expression of claudin-5(Y148A), (Y158A) or (E159Q) enhanced permeability of FITC-dextran(10 kDa), which was unchanged in cells expressing claudin-5(wild type) or claudin-5(R145A).	fluorescein isothiocyanate dextran	76-88	claudin 5	Mus musculus	14-23
21151895-4	2010	Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression.	Tetradecanoylphorbol Acetate	25-28	claudin 5	Mus musculus	248-257
21151895-4	2010	Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression.	Cilostazol	34-44	claudin 5	Mus musculus	248-257
20711499-10	2010	DP treatment decreases vascular adhesion molecule and chemokine expression, while upregulating the tight junction molecule claudin-5.	Dipyridamole	0-2	claudin 5	Mus musculus	123-132
19910637-4	2010	Treatment of these cells with 17beta-estradiol (E2) led to an increase in transendothelial electric resistance and a most prominent upregulation of the tight junction protein claudin-5 expression.	Estradiol	30-46	claudin 5	Mus musculus	175-184
20064788-8	2010	RESULTS: Oral administration of coplanar PCB126, mono-ortho-substituted PCB118, and non-coplanar PCB153 (each at 150 micromol/kg body weight) differentially altered expression of the TJ proteins claudin-5, occludin, and zonula occludens-1 in brain capillaries.	2,4,5,2',4',5'-hexachlorobiphenyl	97-103	claudin 5	Mus musculus	195-204
19819031-2	2009	MPTP treatment induced a significant loss of dopaminergic neurons, decreased expressions of claudin 1, claudin 5 and occludin in the substantia nigra compacta (SNc), and functional damage of the blood brain barrier (BBB).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	claudin 5	Mus musculus	103-112
19453913-8	2009	DPO-based multiplex PCR revealed a profound decrease in the gene expression of endothelium-specific cell-to-cell junction proteins, including claudin-5, VE-cadherin, and PECAM-1, in hypercholesterolemic mice compared with that in controls.	dpo	0-3	claudin 5	Mus musculus	142-151
18509865-3	2008	RESULTS: We have shown a significant decrease in claudin-5 mRNA levels 24 and 48 hours post-delivery of siRNA, with levels of protein expression decreasing up to 48 hours post-injection compared to uninjected, phosphate-buffered saline (PBS)-injected and non-targeting siRNA-injected mice.	Phosphate-Buffered Saline	210-235	claudin 5	Mus musculus	49-58
18635843-10	2008	The vascular tight junction protein claudin-5 underwent extensive degradation in the peri-infarct area, which was partially prevented by the lipoxygenase inhibitor baicalein.	baicalein	164-173	claudin 5	Mus musculus	36-45
18996436-2	2009	Recently, we have shown that claudin-5 protein is down-regulated by the proinflammatory cytokine TNF alpha and its levels restored by dexamethasone treatment.	Dexamethasone	134-147	claudin 5	Mus musculus	29-38
18996436-8	2009	Dexamethasone treatment led to a significant increase of the murine claudin-5 promoter activity and mRNA levels in cEND cells.	Dexamethasone	0-13	claudin 5	Mus musculus	68-77
18509865-3	2008	RESULTS: We have shown a significant decrease in claudin-5 mRNA levels 24 and 48 hours post-delivery of siRNA, with levels of protein expression decreasing up to 48 hours post-injection compared to uninjected, phosphate-buffered saline (PBS)-injected and non-targeting siRNA-injected mice.	pbs	237-240	claudin 5	Mus musculus	49-58
17392177-4	2007	Hypoxia (1% O(2)) altered the location of claudin-5 in the plasma membrane and the level of claudin-5 protein in bEND.3 cells, and these changes were accompanied by a decrease in the transendothelial electrical resistance.	o(2)	12-16	claudin 5	Mus musculus	42-51
17392177-4	2007	Hypoxia (1% O(2)) altered the location of claudin-5 in the plasma membrane and the level of claudin-5 protein in bEND.3 cells, and these changes were accompanied by a decrease in the transendothelial electrical resistance.	o(2)	12-16	claudin 5	Mus musculus	92-101
14576355-3	2003	MCP-1 induces reorganization of actin cytoskeleton (stress fiber formation) and redistribution of tight junction proteins, ZO-1, ZO-2 occludin and claudin-5, from the Triton X-100-soluble to the Triton X-100-insoluble fractions.	Octoxynol	167-179	claudin 5	Mus musculus	147-156
14676305-6	2003	Moreover, SB-431542 up-regulated the expression of claudin-5, an endothelial specific component of tight junctions.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	10-19	claudin 5	Mus musculus	51-60
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	ethylene dichloride	259-266	claudin 5	Mus musculus	233-242
32796132-9	2020	Decreases in the expression of ZO-1 and claudin-5 were partially restored by JWH015.	JHW 015	77-83	claudin 5	Mus musculus	40-49
34904960-7	2021	Both TiO2-NPs induced significant oxidative stress, decreased the expression of TJ proteins (occludin, ZO-1 and claudin 5), damaged the TJ structure, and exhibited enlarged gaps between TM-4 cells.	tio2-nps	5-13	claudin 5	Mus musculus	112-121
34605354-9	2021	We found that compared to the Sham group, the elevated neurological deficit score and brain water content increased production of inflammatory factors, increased BBB permeability, and downregulated Claudin 5 expression were observed in the MCAO group and were all dramatically reversed by the administration of Pimavanserin.	pimavanserin	311-323	claudin 5	Mus musculus	198-207
34605354-11	2021	The significantly increased lactate dehydrogenase (LDH) release, declined cell viability, increased endothelial permeability, downregulated Claudin 5 and Kruppel-like factors 6 (KLF6) were observed in the OGD/R group and were all reversed by the introduction of Pimavanserin.	pimavanserin	262-274	claudin 5	Mus musculus	140-149
34605354-12	2021	Lastly, the effects of Pimavanserin on the expression level of Claudin 5 and endothelial permeability in OGD/R-challenged endothelial cells were both abolished by the knockdown of KLF6.	pimavanserin	23-35	claudin 5	Mus musculus	63-72
34420157-4	2021	ATN-161 treatment (10 microM) effectively inhibited OGD/R-induced extracellular matrix (ECM) deposition by reducing integrin alpha5, MMP-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ROS, inflammation by reducing NLRP3 inflammasome, tight junction loss by reducing claudin-5 and ZO-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-FAK and p-AKT levels.	acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide	0-7	claudin 5	Mus musculus	348-357
34769307-4	2021	An in vitro study showed that high glucose treatment disrupted the junctional distribution of claudin-5 in bEnd3 cells and ZO-1 in ARPE19 cells and that tofacitinib citrate treatment prevented high glucose-mediated tight junction disruption.	Glucose	35-42	claudin 5	Mus musculus	94-103
34769307-4	2021	An in vitro study showed that high glucose treatment disrupted the junctional distribution of claudin-5 in bEnd3 cells and ZO-1 in ARPE19 cells and that tofacitinib citrate treatment prevented high glucose-mediated tight junction disruption.	tofacitinib	153-172	claudin 5	Mus musculus	94-103
34769307-4	2021	An in vitro study showed that high glucose treatment disrupted the junctional distribution of claudin-5 in bEnd3 cells and ZO-1 in ARPE19 cells and that tofacitinib citrate treatment prevented high glucose-mediated tight junction disruption.	Glucose	198-205	claudin 5	Mus musculus	94-103
34685627-4	2021	Moreover, pretreatment with fluorocitrate, an inhibitor of reactive astrocytes, could also reverse the alteration in protein expression levels of GFAP, S100B, Iba-1, CD11b, TNF-alpha, IL-6, iNOS, VCAM-1, ICAM-1, MMP-9, occludin, and claudin 5 in the brain of 1,2-DCE intoxicated mice.	fluorocitrate	28-41	claudin 5	Mus musculus	233-242
34571834-2	2021	Recently, it has been reported that haloperidol, an antipsychotic medication, dose-dependently increases expression of claudin-5 in vitro and in vivo, in brain endothelium.	Haloperidol	36-47	claudin 5	Mus musculus	119-128
34571834-5	2021	We hypothesized that haloperidol increases lung EC claudin-5 expression and attenuates agonist-induced lung EC barrier disruption.	Haloperidol	21-32	claudin 5	Mus musculus	51-60
34571834-11	2021	Finally, mice pretreated with haloperidol (4 mg/kg, IP) prior to the intratracheal administration of LPS (1.25 mg/kg, 16 h) had increased lung claudin-5 expression with decreased lung injury as assessed by bronchoalveolar lavage (BAL) fluid protein content, total cell counts, and inflammatory cytokines, in addition to lung histology.	Haloperidol	30-41	claudin 5	Mus musculus	143-152
34571834-12	2021	Our data confirm that haloperidol results in increased claudin-5 expression levels and demonstrates lung vascular-protective effects both in vitro and in vivo in a murine ALI model.	Haloperidol	22-33	claudin 5	Mus musculus	55-64
35062973-9	2022	Met-R treatment decreased expression of p-SRC, Rac1, albumin, and MMP9, but increased claudin-5, occludin, and ZO-1 tight junction proteins after ICH.	met-r	0-5	claudin 5	Mus musculus	86-95
34356895-8	2021	Blocking JAK1 with Tofacitinib prevented IL-17A-mediated claudin-5 dysmorphia in bEnd.3 cells and reduced albumin leakage in IL-17A-treated mice.	tofacitinib	19-30	claudin 5	Mus musculus	57-66
35588994-8	2022	In addition, R-Lipo-CAPE-treated mice displayed a prominent down-regulated expression of MMP-9 and restored expression of the tight junction protein claudin-5.	r-lipo-cape	13-24	claudin 5	Mus musculus	149-158
35490836-8	2022	Intravitreal injection of anti-OPN neutralizing antibody (anti-OPN Ab) suppressed vascular hyperpermeability and prevented decreases in claudin-5 and ZO-1 gene expression levels in the retina of STZ mice.	Streptozocin	195-198	claudin 5	Mus musculus	136-145
35490836-9	2022	Immunohistochemical staining of retinal vessels in STZ mice revealed claudin-5 immunoreactivity with punctate distribution and attenuated ZO-1 immunoreactivity, and these changes were prevented by anti-OPN Ab.	Streptozocin	51-54	claudin 5	Mus musculus	69-78
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Vitamin D	18-27	claudin 5	Mus musculus	111-120
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Vitamin D	18-27	claudin 5	Mus musculus	165-174
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Cholecalciferol	146-156	claudin 5	Mus musculus	111-120
35338345-8	2022	We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression.	Cholecalciferol	146-156	claudin 5	Mus musculus	165-174
35245993-6	2022	In Hcy-stimulated HBVECs, increased endothelial permeability and reduced expression levels of Claudin-5 and Kruppel-like factor 5 (KLF5) were observed, all of which were dramatically rescued by 2 and 5 microM butorphanol tartrate.	Homocysteine	3-6	claudin 5	Mus musculus	94-103
35245993-6	2022	In Hcy-stimulated HBVECs, increased endothelial permeability and reduced expression levels of Claudin-5 and Kruppel-like factor 5 (KLF5) were observed, all of which were dramatically rescued by 2 and 5 microM butorphanol tartrate.	Butorphanol	209-229	claudin 5	Mus musculus	94-103
35245993-8	2022	Collectively, butorphanol tartrate showed protective effects on Hcy-induced BBB disruption by upregulating the KLF5/Claudin-5 axis.	Butorphanol	14-34	claudin 5	Mus musculus	116-125
35245993-8	2022	Collectively, butorphanol tartrate showed protective effects on Hcy-induced BBB disruption by upregulating the KLF5/Claudin-5 axis.	Homocysteine	64-67	claudin 5	Mus musculus	116-125
34393764-12	2021	Exposure of BEND3 cells, mouse brain-derived Endothelial cells3, to a combination of high glucose and palmitic acid resulted in significant (P < 0.01-P < 0.001) decreases in the levels of SIRT3, claudin-5 and ZO-1.	Glucose	90-97	claudin 5	Mus musculus	195-204
34393764-12	2021	Exposure of BEND3 cells, mouse brain-derived Endothelial cells3, to a combination of high glucose and palmitic acid resulted in significant (P < 0.01-P < 0.001) decreases in the levels of SIRT3, claudin-5 and ZO-1.	Palmitic Acid	102-115	claudin 5	Mus musculus	195-204
34167621-5	2021	Our data showed that nano TiO2 reduced Occludin, ZO-1 and Claudin-5 expression.	titanium dioxide	26-30	claudin 5	Mus musculus	58-67
35561751-6	2022	Meanwhile, Sal administration reversed the degradation of tight junction proteins ZO-1, Occludin and Claudin-5.	rhodioloside	11-14	claudin 5	Mus musculus	101-110
35343071-8	2022	Mechanistically, lithium upregulated the activity of endothelial Wnt/beta-catenin signaling in mice and increased the levels of tight junction proteins (occludin, claudin-5 and ZO-1).	Lithium	17-24	claudin 5	Mus musculus	163-172
35490836-13	2022	Immunofluorescence localization of claudin-5 and ZO-1 demonstrated punctate appearance with discontinuous junction in HRECs exposed to high glucose and OPN.	Glucose	140-147	claudin 5	Mus musculus	35-44
35422069-6	2022	We show that targeted disruption of claudin-5 in the hippocampus or genetic heterozygosity of claudin-5 in mice exacerbates kainic acid-induced seizures and BBB disruption.	Kainic Acid	124-135	claudin 5	Mus musculus	36-45
35422069-6	2022	We show that targeted disruption of claudin-5 in the hippocampus or genetic heterozygosity of claudin-5 in mice exacerbates kainic acid-induced seizures and BBB disruption.	Kainic Acid	124-135	claudin 5	Mus musculus	94-103
35245993-5	2022	We found that the increased diffusion of sodium fluorescein and Evan"s blue, declined expression of Claudin-5, and increased production of interleukin- 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were observed in Hcy-treated mice, which were all significantly reversed by butorphanol tartrate.	Homocysteine	222-225	claudin 5	Mus musculus	100-109