PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35501237-12	2022	FNR648-labeled CLDN3 antibody bound to the cell surface of OVCAR-3 and U87MG with 83.4% and 5.7% specificity, respectively.	fnr648	0-6	claudin 3	Mus musculus	15-20
33866021-8	2021	Nevertheless, by RNAseq we detected a downregulation of metabolic pathways in the livers of Cldn3-/- young and aged mice as well as a decrease in lipid content and a weakened biliary-barrier for primary bile acids, such as TCA, TCDCA and TMCA.	Taurochenodeoxycholic Acid	228-233	claudin 3	Mus musculus	92-97
35251039-5	2022	Additionally, HEO and SME-HEO protected the integrity of the BMB by upregulating the expression of junction proteins ZO-1, claudin-1, claudin-3, and occludin.	heme O	14-17	claudin 3	Mus musculus	134-143
33866021-8	2021	Nevertheless, by RNAseq we detected a downregulation of metabolic pathways in the livers of Cldn3-/- young and aged mice as well as a decrease in lipid content and a weakened biliary-barrier for primary bile acids, such as TCA, TCDCA and TMCA.	3,4,5-trimethoxycinnamic acid	238-242	claudin 3	Mus musculus	92-97
33866021-10	2021	CONCLUSION: Our data shows that in the liver, claudin-3 is necessary to maintain metabolic homeostasis, retention of bile acids, and optimal hepatocyte proliferation during liver regeneration.	Bile Acids and Salts	117-127	claudin 3	Mus musculus	46-55
33503995-3	2021	Mice were fed diets containing whole LP powder, MetOH extract, and MetOH residue for 16 d. DSS administration for 9 d induced bodyweight loss, reduced colon length, reduced the colonic expression of tight junction proteins including zonula occludens-1 and -2, and claudin-3 and -7, and upregulated colonic mRNA expression of interleukin 6, chemokine (C-X-C motif) ligand 2, and C-C motif chemokine ligand 2.	Dextran Sulfate	91-94	claudin 3	Mus musculus	264-280
32361923-10	2021	Additionally, BJ-1108 limited intestinal permeability and enhanced the expression of tight junction (TJ) proteins such as claudin-1 and claudin-3 in the DSS-induced colitis model.	BJ-1108	14-21	claudin 3	Mus musculus	136-145
30213590-5	2018	RESULTS: In the liver of Cldn3-knockout mice, the paracellular phosphate ion permeability through hepatic tight junctions was significantly increased, resulting in calcium phosphate core formation.	Phosphates	63-72	claudin 3	Mus musculus	25-30
32354638-8	2020	Lithocholic acid suppressed intestinal mucosal claudin 3 and occludin in wild-type mice, but not in vitamin D receptor knockout mice.	Lithocholic Acid	0-16	claudin 3	Mus musculus	47-56
32354638-9	2020	Everted gut sacs of claudin 3 knockout mice showed an increased permeability for phosphate, but not calcium.	Phosphates	81-90	claudin 3	Mus musculus	20-29
32354638-13	2020	Thus, lithocholic acid and claudin 3 may represent novel therapeutic targets for reducing phosphate burden.	Phosphates	90-99	claudin 3	Mus musculus	27-36
31152671-6	2019	The ZJ617s + LPS group exhibited higher intestinal expression of claudin 3 (62.5%), occludin (60.1%), and zonula occludens 1 (60.5%) compared with the LPS group (P < 0.05).	zj617s	4-10	claudin 3	Mus musculus	65-74
30802726-4	2019	Moreover, protein expression of two tight junction proteins, claudin-3 and junctional adhesion molecule-A, was higher in DSS-administered mice that were fed naringenin than in the mice that did not receive naringenin.	dss	121-124	claudin 3	Mus musculus	61-105
30802726-4	2019	Moreover, protein expression of two tight junction proteins, claudin-3 and junctional adhesion molecule-A, was higher in DSS-administered mice that were fed naringenin than in the mice that did not receive naringenin.	naringenin	157-167	claudin 3	Mus musculus	61-105
30802726-4	2019	Moreover, protein expression of two tight junction proteins, claudin-3 and junctional adhesion molecule-A, was higher in DSS-administered mice that were fed naringenin than in the mice that did not receive naringenin.	naringenin	206-216	claudin 3	Mus musculus	61-105
33032263-11	2020	Additionally, S-PT84 reduced the recruitment of interleukin-17-producing T cells and increased the levels of intestinal tight junction proteins, including zonula occludens-1, occludin, claudin-3, and claudin-7.	s-pt84	14-20	claudin 3	Mus musculus	185-194
30858849-9	2019	The in vitro results demonstrated that licochalcone A inhibited LPS-induced inflammatory responses and increase the protein levels of ZO-1, occludin, and claudin3 in mMECs.	licochalcone A	39-53	claudin 3	Mus musculus	154-162
30213590-5	2018	RESULTS: In the liver of Cldn3-knockout mice, the paracellular phosphate ion permeability through hepatic tight junctions was significantly increased, resulting in calcium phosphate core formation.	calcium phosphate	164-181	claudin 3	Mus musculus	25-30
30213590-7	2018	CONCLUSION: We revealed that in the hepatobiliary system, Cldn3 functions as a paracellular barrier for phosphate ions, to help maintain biliary ion homeostasis.	Phosphates	104-113	claudin 3	Mus musculus	58-63
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	62-67
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	75-80
29277540-6	2018	This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3.	Water	22-27	claudin 3	Mus musculus	129-138
24482188-0	2014	Antitumor effects of heparin-polyethyleneimine nanogels delivering claudin-3-targeted short hairpin RNA combined with low-dose cisplatin on ovarian cancer.	Heparin	21-28	claudin 3	Mus musculus	67-76
28800679-7	2017	SB up-regulated the tight junction proteins occludin and claudin-3 and reduced blood-milk barrier permeability in LPS-induced mastitis.	Butyric Acid	0-2	claudin 3	Mus musculus	57-66
28966615-7	2017	Our results show that sodium propionate strikingly increases the expressions of occludin and claudin-3 and reduces the blood-milk barrier permeability in this model.	sodium propionate	22-39	claudin 3	Mus musculus	93-102
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	claudin 3	Mus musculus	108-117
29017935-5	2018	In bEnd.3 brain-derived endothelial cells, DHEAS stimulates the expression of zonula occludens-1 and claudin-3 and promotes tight junction formation between neighboring cells, which at the blood-brain barrier protects the brain from harmful factors and cells.	Dehydroepiandrosterone Sulfate	43-48	claudin 3	Mus musculus	101-110
29183964-6	2018	Also, transplanted germ cells were capable of inducing Leydig cell testosterone production, which could enhance the expression of integral membrane protein claudin 3 in Sertoli cells.	Testosterone	67-79	claudin 3	Mus musculus	156-165
27605405-12	2016	The DSS+10% GG and PHGG groups showed ~110%, 60%, 120%, and 110% greater (P < 0.05) expression of occludin and claudin 3, 4, and 7, respectively, in the colon than did the DSS group.	dss	4-7	claudin 3	Mus musculus	114-123
27130254-9	2016	The inhibition of Prl secretion by bromocriptine in lactating mice induced the upregulation of Cldn3 and Cldn4 concurrent with the downregulation of milk production.	Bromocriptine	35-48	claudin 3	Mus musculus	95-100
26941614-7	2016	Using an improved fixation strategy (4% paraformaldehyde at pH 11, in the presence of EDTA) and the sensitive alkaline phosphatase as a detection system, we show that claudin-3 is present in mouse epithelia from embryonic day 14 onwards.	paraform	40-56	claudin 3	Mus musculus	167-176
26941614-7	2016	Using an improved fixation strategy (4% paraformaldehyde at pH 11, in the presence of EDTA) and the sensitive alkaline phosphatase as a detection system, we show that claudin-3 is present in mouse epithelia from embryonic day 14 onwards.	Edetic Acid	86-90	claudin 3	Mus musculus	167-176
26541656-10	2015	CONCLUSION: The combination of neomycin and bacitracin reduce intestinal permeability and increase the gene expression of ZO-1, junctional adhesion molecule A (JAM-A), and occludin in the ileum and ZO-1, claudin-3, and claudin-4 in the colon.	Neomycin	31-39	claudin 3	Mus musculus	204-213
26541656-10	2015	CONCLUSION: The combination of neomycin and bacitracin reduce intestinal permeability and increase the gene expression of ZO-1, junctional adhesion molecule A (JAM-A), and occludin in the ileum and ZO-1, claudin-3, and claudin-4 in the colon.	Bacitracin	44-54	claudin 3	Mus musculus	204-213
26019243-12	2015	In mice, GOSs prevented the deoxynivalenol-induced mRNA overexpression of claudin3 (P = 0.022) and CXCL8 homolog keratinocyte hemoattractant (Kc) (Cxcl1) (P = 0.06) as well as the deoxynivalenol-induced morphologic defects.	deoxynivalenol	28-42	claudin 3	Mus musculus	74-82
24966923-6	2014	In CR infected model, cladudin-1 and claudin-3 expression significantly decreased compared with the control mice (P<0.05); after octreotide treatment, claudin-1 and claudin-3 expression significantly increased compared with untreated CR infected mice (P<0.05).	Octreotide	132-142	claudin 3	Mus musculus	168-177
24966923-7	2014	In DSS colitis model, occludin and claudin-3 expression significantly decreased compared with the control mice (P<0.05); and octreotide treatment could only significantly upregulate claudin-3 expression compared with untreated DSS colitis mice (P<0.05).	Dextran Sulfate	3-6	claudin 3	Mus musculus	35-44
24966923-7	2014	In DSS colitis model, occludin and claudin-3 expression significantly decreased compared with the control mice (P<0.05); and octreotide treatment could only significantly upregulate claudin-3 expression compared with untreated DSS colitis mice (P<0.05).	Octreotide	128-138	claudin 3	Mus musculus	185-194
24482188-0	2014	Antitumor effects of heparin-polyethyleneimine nanogels delivering claudin-3-targeted short hairpin RNA combined with low-dose cisplatin on ovarian cancer.	aziridine	29-46	claudin 3	Mus musculus	67-76
23909989-12	2013	In ovariectomized mice, P induces Claudin-3 expression in the luminal epithelium, which is abrogated by P receptor antagonist RU486.	Mifepristone	126-131	claudin 3	Mus musculus	34-43
23959874-5	2013	Here, we show that the orally available small molecule LY-317615, a synthetic bisindolylmaleimide and inhibitor of protein kinase Cbeta, which is clinically under investigation for the treatment of cancer, suppresses the transmigration of activated T cells through an inflamed endothelial cell barrier, where it leads to the induction of the tight-junction molecules zona occludens-1, claudin 3, and claudin 5 and other pathways critically involved in transendothelial leukocyte migration.	enzastaurin	55-64	claudin 3	Mus musculus	385-394
23677978-8	2013	Moreover, claudin 3 knockdown resulted in a prolonged preleptotene phase during spermatogenesis.	preleptotene	54-66	claudin 3	Mus musculus	10-19
22623623-10	2012	In hpg testes, DHT treatment stimulated the redistribution of claudin-11 protein toward the basal region of Sertoli cells by Day 2, increased Cldn3 and Cldn11 mRNA expression, then induced the formation of functional TJs containing both proteins by Day 10.	Dihydrotestosterone	15-18	claudin 3	Mus musculus	142-147
21291956-5	2011	The administration of RU-486, a progesterone receptor (PR) antagonist, into pregnant mice adversely affects the localization and expression of claudin-3 and claudin-4 in the amniotic epithelium.	Mifepristone	22-28	claudin 3	Mus musculus	143-152
34831451-2	2021	Here, we found that the TJ proteins claudin-1 and claudin-3 were significantly increased in the submandibular glands (SMGs) of db/db mice and high glucose (HG)-treated human SMGs.	Glucose	147-154	claudin 3	Mus musculus	50-59
23596159-6	2013	DSS administration also impaired TJ barrier integrity in the colon, as indicated by increased colon permeability and plasma LPS-binding protein levels, resulting from the impaired colonic expression of TJ proteins, occludin, junctional adhesion molecule-A, and claudin-3.	Dextran Sulfate	0-3	claudin 3	Mus musculus	261-270
23626786-7	2013	First, a qualitative change in claudin-3, presumably caused by phosphorylation and participation of claudin-7 in alveolar TJs, was recognized in parallel with the leakage of fluorescein isothiocyanate-conjugated albumin (FITC-albumin) via the alveolar epithelium.	Fluorescein-5-isothiocyanate	174-200	claudin 3	Mus musculus	31-40
23626786-7	2013	First, a qualitative change in claudin-3, presumably caused by phosphorylation and participation of claudin-7 in alveolar TJs, was recognized in parallel with the leakage of fluorescein isothiocyanate-conjugated albumin (FITC-albumin) via the alveolar epithelium.	Fluorescein-5-isothiocyanate	221-225	claudin 3	Mus musculus	31-40
19208807-3	2009	Here, we investigated the efficacy of lipidoid-formulated CLDN3 siRNA in 3 different ovarian cancer models.	lipidoid	38-46	claudin 3	Mus musculus	58-63
19208807-5	2009	Intraperitoneal injection of lipidoid-formulated CLDN3 siRNA resulted in a substantial reduction in tumor burden in MISIIR/TAg transgenic mice and mice bearing tumors derived from mouse ovarian surface epithelial cells.	lipidoid	29-37	claudin 3	Mus musculus	49-54
19208807-9	2009	Importantly, treatment of mice with nonimmunostimulatory 2"-OMe modified CLDN3 siRNA was as effective in suppressing tumor growth as unmodifed siRNA.	2"-ome	57-63	claudin 3	Mus musculus	73-78
19208807-10	2009	These results suggest that lipidoid-formulated CLDN3 siRNA has potential as a therapeutic for ovarian cancer.	lipidoid	27-35	claudin 3	Mus musculus	47-52