PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29953775-3	2017	Resistence of ovarian cancer cells to paclitaxel and cisplatin is associated with a reduced expression of miR-30c, miR-130, and miR335, which results in activation of M-CSF, the known factor of resistance to cytostatic drugs.	Paclitaxel	38-48	microRNA 30c-1	Homo sapiens	106-113
29953775-3	2017	Resistence of ovarian cancer cells to paclitaxel and cisplatin is associated with a reduced expression of miR-30c, miR-130, and miR335, which results in activation of M-CSF, the known factor of resistance to cytostatic drugs.	Cisplatin	53-62	microRNA 30c-1	Homo sapiens	106-113
27649854-1	2016	Circulating miR-30c has been linked to various aspects of cholesterol homeostasis.	Cholesterol	58-69	microRNA 30c-1	Homo sapiens	12-19
27819307-8	2016	miR-30c was negatively correlated with glucose and HbA1c levels in DM2.	Glucose	39-46	microRNA 30c-1	Homo sapiens	0-7
27649854-7	2016	In the non-ALP group there was significant correlation between miR-30c and components within VLDL1, namely triglyceride which showed a negative association (p=0.035) whereas phospholipids and cholesterol-ester were both positively correlated (p=0.025 and 0.014, respectively).	Triglycerides	107-119	microRNA 30c-1	Homo sapiens	63-70
27649854-8	2016	In contrast, in the ALP group there was a significant correlation between the expression of miR-30c and components within VLDL2, namely triglyceride, which was positively associated (p=0.013).	Triglycerides	136-148	microRNA 30c-1	Homo sapiens	92-99
26775556-10	2016	Interestingly, miR-30c expression was negatively correlated with ACR (r=-0.870, P=0.003) and positively correlated with Ccr (r=0.8230, P=0.01), whereas it was uncorrelated with KW/BW, SBP, HbA1C, HOMR-IR and T-Cho (p>0.05).	CAV protocol	210-213	microRNA 30c-1	Homo sapiens	15-22
27469029-7	2016	In addition, we found that miR-30c inhibited dimethyl sulfoxide-induced differentiation of P19 cells.	Dimethyl Sulfoxide	45-63	microRNA 30c-1	Homo sapiens	27-34
26968781-8	2016	KEY FINDINGS: MiR-30c could increase the expression of NKG2D and CD107a on NKL cells, and enhance cytotoxic ability of NKL cells to kill SMMC-7721 cells.	smmc	137-141	microRNA 30c-1	Homo sapiens	14-21
26473850-7	2015	The few available studies investigating microRNA in patients suggest that seven microRNAs (miR-10a, miR-26, miR-30c, miR-126a, miR-210, miR-342 and miR-519a) play a role in tamoxifen resistance.	Tamoxifen	173-182	microRNA 30c-1	Homo sapiens	108-115
26707189-0	2016	Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer.	linderalactone	0-17	microRNA 30c-1	Homo sapiens	83-90
26707189-6	2016	Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p (miR-30c) expression.	linderalactone	77-94	microRNA 30c-1	Homo sapiens	130-137
26707189-6	2016	Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p (miR-30c) expression.	linderalactone	77-94	microRNA 30c-1	Homo sapiens	142-149
26707189-8	2016	In conclusion, isolinderalactone induces apoptosis in MDA-MB-231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c.	linderalactone	15-32	microRNA 30c-1	Homo sapiens	142-149
26149869-0	2015	Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury.	Hydrogen Sulfide	0-16	microRNA 30c-1	Homo sapiens	64-71
26149869-6	2015	Quantitative Real-Time PCR or Western blotting results showed that H2S pretreatment also downregulated miR-30c expression and upregulated Beclin-1 and LC3II expression in spinal cord.	Hydrogen Sulfide	67-70	microRNA 30c-1	Homo sapiens	103-110
26149869-8	2015	In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S.	Hydrogen Sulfide	140-143	microRNA 30c-1	Homo sapiens	48-55
26149869-9	2015	CONCLUSION: H2S protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord hemia-reperfusion injury.	Hydrogen Sulfide	12-15	microRNA 30c-1	Homo sapiens	63-70
24519092-3	2014	miR-30c was downregulated in the doxorubicin-resistant human breast cancer cell lines MCF-7/ADR and MDA-MB-231/ADR compared with their parental MCF-7 and MDA-MB-231 cell lines, respectively.	Doxorubicin	33-44	microRNA 30c-1	Homo sapiens	0-7
25882492-4	2015	Inhibition of miR-30c by either hypoxia or AMO-30c results in PASMC proliferation (cell viability, 5-bromo-2-deoxyuridine (BrdU) incorporation, proliferating cell nuclear antigen, Ki67, and tubulin polymerization) and the inhibition of apoptosis (cell cycle progression, Cyclin A and Cyclin D, and TUNEL staining).	amo-30c	43-50	microRNA 30c-1	Homo sapiens	14-21
25882492-4	2015	Inhibition of miR-30c by either hypoxia or AMO-30c results in PASMC proliferation (cell viability, 5-bromo-2-deoxyuridine (BrdU) incorporation, proliferating cell nuclear antigen, Ki67, and tubulin polymerization) and the inhibition of apoptosis (cell cycle progression, Cyclin A and Cyclin D, and TUNEL staining).	pasmc	62-67	microRNA 30c-1	Homo sapiens	14-21
25882492-4	2015	Inhibition of miR-30c by either hypoxia or AMO-30c results in PASMC proliferation (cell viability, 5-bromo-2-deoxyuridine (BrdU) incorporation, proliferating cell nuclear antigen, Ki67, and tubulin polymerization) and the inhibition of apoptosis (cell cycle progression, Cyclin A and Cyclin D, and TUNEL staining).	Bromodeoxyuridine	99-121	microRNA 30c-1	Homo sapiens	14-21
25882492-4	2015	Inhibition of miR-30c by either hypoxia or AMO-30c results in PASMC proliferation (cell viability, 5-bromo-2-deoxyuridine (BrdU) incorporation, proliferating cell nuclear antigen, Ki67, and tubulin polymerization) and the inhibition of apoptosis (cell cycle progression, Cyclin A and Cyclin D, and TUNEL staining).	Bromodeoxyuridine	123-127	microRNA 30c-1	Homo sapiens	14-21
24623846-7	2014	Among the miRNAs modulated by DHA were miR-192 and miR-30c.	Docosahexaenoic Acids	30-33	microRNA 30c-1	Homo sapiens	51-58
24519092-0	2014	Involvement of miR-30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells.	Doxorubicin	40-51	microRNA 30c-1	Homo sapiens	15-22
24519092-2	2014	The aim of this study was to investigate whether miR-30c mediated the resistance of breast cancer cells to the chemotherapeutic agent doxorubicin (ADR) by targeting tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ).	Doxorubicin	134-145	microRNA 30c-1	Homo sapiens	49-56
24519092-4	2014	Furthermore, we observed that transfection of an miR-30c mimic significantly suppressed the ability of MCF-7/ADR to resist doxorubicin.	Doxorubicin	123-134	microRNA 30c-1	Homo sapiens	49-56
24519092-6	2014	Together, our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR.	Doxorubicin	89-100	microRNA 30c-1	Homo sapiens	46-53
22139444-7	2012	MTT assay             and growth curves revealed that miR-30c inhibits both Ishikawa and HEC-1-B cell             proliferation.	monooxyethylene trimethylolpropane tristearate	0-3	microRNA 30c-1	Homo sapiens	54-61
23316327-7	2012	CASMCs transfected with antagomirs to downregulate miR-30b-c demonstrated significantly increased Runx2, intracellular calcium deposition, and mineralization.	Calcium	119-126	microRNA 30c-1	Homo sapiens	51-60
24286402-5	2013	METHODS: We have therefore retrospectively examined expression of miR-30b miR-30c in 41 formalin fixed paraffin embedded tissue samples from NSCLC patients when TKIs were used as first line therapy.	Formaldehyde	88-96	microRNA 30c-1	Homo sapiens	74-81
23318178-0	2013	Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines.	sulfuretin	0-10	microRNA 30c-1	Homo sapiens	19-26
23318178-6	2013	In addition, silencing miR-30C expression partially reversed sulfuretin-induced cell death.	sulfuretin	61-71	microRNA 30c-1	Homo sapiens	23-30
21880628-9	2011	Furthermore, our data showed that deregulated expression of tumor suppressor microRNAs, such as miR-29a and miR-30c, might contribute to sensitivity to cytarabine, which is observed in NPM1 mutated acute myeloid leukemia.	Cytarabine	152-162	microRNA 30c-1	Homo sapiens	108-115
21878751-6	2011	miR-30c expression was increased during adipogenesis of human multipotent adipose-derived stem (hMADS) cells, and miR-30c overexpression enforced adipocyte marker gene induction and triglyceride accumulation.	Triglycerides	182-194	microRNA 30c-1	Homo sapiens	114-121
19948396-7	2010	And indeed, different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1.	Fluorouracil	248-262	microRNA 30c-1	Homo sapiens	93-100
20490652-4	2011	Univariate analysis showed that higher expression levels of hsa-miR-30a-3p, hsa-miR-30c, and hsa-miR-182 were significantly associated with benefit of tamoxifen treatment and with longer PFS (all P-values <0.01).	Tamoxifen	151-160	microRNA 30c-1	Homo sapiens	80-87
34402004-6	2021	A total of 11 differentially expressed PAH-responsive miRNAs were observed each in two or more cell-based studies (miR-181a and miR-30c-1), animal model studies (miR-291a and miR-292), and human population-based studies (miR-126, miR-142-5p, miR-150-5p, miR-24-3p, miR-27a-3p, miR-28-5p, and miR-320b).	Polycyclic Aromatic Hydrocarbons	39-42	microRNA 30c-1	Homo sapiens	128-137
34172072-17	2021	CONCLUSIONS: Our findings suggest that circ3823 promotes CRC growth, metastasis and angiogenesis through circ3823/miR-30c-5p/TCF7 axis and it may serve as a new diagnostic marker or target for treatment of CRC patients.	circ3823	39-47	microRNA 30c-1	Homo sapiens	114-121
32391974-0	2020	LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3.	Glucose	28-35	microRNA 30c-1	Homo sapiens	100-107
35212616-0	2022	Lidocaine represses proliferation and cisplatin resistance in cutaneous squamous cell carcinoma via miR-30c/SIRT1 regulation.	Lidocaine	0-9	microRNA 30c-1	Homo sapiens	100-107
35212616-0	2022	Lidocaine represses proliferation and cisplatin resistance in cutaneous squamous cell carcinoma via miR-30c/SIRT1 regulation.	Cisplatin	38-47	microRNA 30c-1	Homo sapiens	100-107
35212616-4	2022	Lidocaine suppressed A431 cell proliferation and cisplatin resistance in a dose- and time-dependent manner via the miR-30c/SIRT1 pathway.	Lidocaine	0-9	microRNA 30c-1	Homo sapiens	115-122
35212616-4	2022	Lidocaine suppressed A431 cell proliferation and cisplatin resistance in a dose- and time-dependent manner via the miR-30c/SIRT1 pathway.	Cisplatin	49-58	microRNA 30c-1	Homo sapiens	115-122
35212616-5	2022	MiR-30c overexpression also suppressed cell proliferation and cisplatin resistance in A431 cells by directly targeting and downregulating SIRT1, thus enhancing the protective effects of lidocaine.	Cisplatin	62-71	microRNA 30c-1	Homo sapiens	0-7
35212616-5	2022	MiR-30c overexpression also suppressed cell proliferation and cisplatin resistance in A431 cells by directly targeting and downregulating SIRT1, thus enhancing the protective effects of lidocaine.	Lidocaine	186-195	microRNA 30c-1	Homo sapiens	0-7
35212616-6	2022	Conversely, SIRT1 upregulation or miR-30c inhibition antagonized the inhibitory effects of lidocaine.	Lidocaine	91-100	microRNA 30c-1	Homo sapiens	34-41
35212616-7	2022	Our results suggest that lidocaine may suppress the progression of cSCC by activating the miR-30c/SIRT1 pathway, indicating its promising potential as a treatment strategy for cSCC.	Lidocaine	25-34	microRNA 30c-1	Homo sapiens	90-97
35078992-0	2022	Correction: Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response.	Doxorubicin	22-32	microRNA 30c-1	Homo sapiens	91-98
35278429-6	2022	Here, we report the successful synthesis of a series of miR-30c analogs by using different chemically modified nucleosides.	Nucleosides	111-122	microRNA 30c-1	Homo sapiens	56-63
35278429-7	2022	In these analogs, we left the active sense strand untouched so that its biological activity remained unaltered, and we modified the passenger strand of miR-30c to enhance the stability and uptake of miR-30c by hepatoma cells through phosphorothiorate linkages and the addition of N-acetyl-galactosamine.	phosphorothiorate	233-250	microRNA 30c-1	Homo sapiens	152-159
35278429-7	2022	In these analogs, we left the active sense strand untouched so that its biological activity remained unaltered, and we modified the passenger strand of miR-30c to enhance the stability and uptake of miR-30c by hepatoma cells through phosphorothiorate linkages and the addition of N-acetyl-galactosamine.	phosphorothiorate	233-250	microRNA 30c-1	Homo sapiens	199-206
35278429-7	2022	In these analogs, we left the active sense strand untouched so that its biological activity remained unaltered, and we modified the passenger strand of miR-30c to enhance the stability and uptake of miR-30c by hepatoma cells through phosphorothiorate linkages and the addition of N-acetyl-galactosamine.	Acetylgalactosamine	280-302	microRNA 30c-1	Homo sapiens	152-159
35278429-7	2022	In these analogs, we left the active sense strand untouched so that its biological activity remained unaltered, and we modified the passenger strand of miR-30c to enhance the stability and uptake of miR-30c by hepatoma cells through phosphorothiorate linkages and the addition of N-acetyl-galactosamine.	Acetylgalactosamine	280-302	microRNA 30c-1	Homo sapiens	199-206
35370727-7	2022	In conclusion, Perftoran  induced the phototoxicity of ICG/PDT and inhibited ICG/PDT-hypoxia via suppressing HIF-alpha/beta, miR-210, miR-21, let-7i, miR-15a, miR-30c, and miR-181a and by inducing the expression of let-7d/f and miR-15b.	perftoran	15-24	microRNA 30c-1	Homo sapiens	159-166
34983557-6	2022	More importantly, Iacs-miR-30c potently suppressed the Wnt signaling pathway in vitro and in vivo, and effectively sensitized both potency of 5-Fu in PDX model of colon cancer and Anti-PD1 in B16F10 homograft model of melanoma.	Fluorouracil	142-146	microRNA 30c-1	Homo sapiens	23-30
33861889-4	2021	Using miRNA profiling of fibrotic murine livers, we identified differentially regulated miRNAs and discovered that miR-30c is aberrantly expressed and targets endothelial delta-like ligand 4 (DLL4) in either carbon tetrachloride-treated or bile duct ligated fibrotic mice, as well as in patients with liver fibrosis.	Carbon Tetrachloride	208-228	microRNA 30c-1	Homo sapiens	115-122
31511498-0	2019	Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response.	Doxorubicin	10-20	microRNA 30c-1	Homo sapiens	79-86
31339402-7	2020	When following up the miRNA findings from the animal study in the human working population, a stronger relationship between NAQ and NRS scores was observed in subjects with the miR-30c GG genotype (rs928508) compared to other subjects.	BDBM493967	124-127	microRNA 30c-1	Homo sapiens	177-184
32143184-5	2020	In this context, the ectopic recovery of miR-30b and miR-30c led to significant changes in genes related to FA metabolism, consistent reduction of ceramides, higher mitochondrial activity, and enabled beta-oxidation, redirecting FA metabolism from energy storage to expenditure.	Ceramides	147-156	microRNA 30c-1	Homo sapiens	53-60
31760103-0	2019	Circulating miR-30c as a predictive biomarker of type 2 diabetes mellitus with coronary heart disease by regulating PAI-1/VN interactions.	vn	122-124	microRNA 30c-1	Homo sapiens	12-19
31760103-5	2019	The effects of miR-30c on VN expression by targeting PAI-1 were assessed in vitro SMC and in ex vivo plasma, using bioinformatic analysis, miRNA transfection, luciferase assays, qRT-PCR and western blot, respectively.	vn	26-28	microRNA 30c-1	Homo sapiens	15-22
31760103-6	2019	KEY FINDINGS: We found that decreased circulating miR-30c was negatively correlated with the severity of coronary lesions and the resulting elevated PAI-1 and VN levels.	vn	159-161	microRNA 30c-1	Homo sapiens	50-57
31760103-8	2019	Furthermore, we also showed that miR-30c plays a previously unrecognized role in regulating the expression of VN levels via regulating PAI-1 levels in vitro SMC and in ex vivo plasma.	vn	110-112	microRNA 30c-1	Homo sapiens	33-40
31760103-9	2019	SIGNIFICANCE: These findings provide a novel regulatory mechanism of miR-30c in regulating PAI-1/VN interactions and that may serve as a diagnostic biomarker of DM2 that is complicated with CHD.	vn	97-99	microRNA 30c-1	Homo sapiens	69-76
30262902-7	2018	The results showed that a large number of oncomiRs, including miR-10a, miR-23a, miR-30c, miR-31, miR-151a and miR-205, were significantly suppressed in baicalin-treated HT-29 cells.	baicalin	152-160	microRNA 30c-1	Homo sapiens	80-87
31447008-0	2019	Circulating miR-30b and miR-30c predict erlotinib response in EGFR-mutated non-small cell lung cancer patients.	Erlotinib Hydrochloride	40-49	microRNA 30c-1	Homo sapiens	24-31
31447008-1	2019	OBJECTIVES: MiR-30b, miR-30c, miR-221 and miR-222 are known to induce gefitinib resistance in lung cancer cell lines with activation of mutations in the epidermal growth factor receptor (EGFR).	Gefitinib	70-79	microRNA 30c-1	Homo sapiens	21-28
30963631-7	2019	Under enzalutamide (Enza) treatment, the effects of AR-V7 overexpression were the opposite of those of miR-103a-2-5p/miR-30c-1-3p overexpression; more importantly, the effects of miR-103a-2-5p/miR-30c-1-3p overexpression could be significantly reversed by AR-V7 overexpression under Enza.	enzalutamide	6-18	microRNA 30c-1	Homo sapiens	193-202
28610790-9	2017	Interestingly, low levels of miR-30c are specific for this active form of TB, as its expression is not altered in mononuclear cells from either healthy controls or patients with tuberculous or non-tuberculous pleurisy.	Terbium	74-76	microRNA 30c-1	Homo sapiens	29-36
29514056-3	2018	Recent studies indicate that a number of signaling pathways are involved in the pro-autophagy effect of H2S, such as PI3K/Akt/mTOR, AMPK/mTOR, LKB1/STRAD/MO25, and miR-30c signaling pathways.	Hydrogen Sulfide	104-107	microRNA 30c-1	Homo sapiens	164-171
30069329-8	2018	The rs11614913 (miR-196a-2) C allele or rs9280508 (miR-30c-1) G allele carriers shown more sensitive to platinum both in additive (P=0.010, P=0.022, respectively) and dominant models (P=0.001, P=0.018, respectively).	Platinum	104-112	microRNA 30c-1	Homo sapiens	51-60
28610790-11	2017	In sum, our studies identify miR-30c as a specific correlate of pulmonary manifestations of TB, potentially involved in the altered glucocorticoid sensitivity observed in these patients.	Terbium	92-94	microRNA 30c-1	Homo sapiens	29-36
28232049-8	2017	All 29 PDAC cases exhibited significantly elevated exosomal miR-10b and miR-30c levels, whereas 8 cases had normal or slightly increased CA 19-9 levels.	pdac	7-11	microRNA 30c-1	Homo sapiens	72-79
28062296-5	2017	Using archived samples from previous studies, the effects of 40mg rosuvastatin (n=22) and 40mg pravastatin (n=24) on miR-30c expression was also examined.	Pravastatin	95-106	microRNA 30c-1	Homo sapiens	117-124
28062296-7	2017	RESULTS: When stratified according to total cholesterol concentration, there was increased miR-30c expression in the highest compared to the lowest tertile (p=0.035).	Cholesterol	44-55	microRNA 30c-1	Homo sapiens	91-98
28062296-8	2017	There was significant positive correlation between miR-30c and total- (r=0.367; p=0.002) and LDL-cholesterol (r=0.391; p=0.001).	Cholesterol	97-108	microRNA 30c-1	Homo sapiens	51-58
28062296-10	2017	There was a 3.8-fold increased expression of circulating miR-30c after pravastatin treatment for 1year (p=0.005) but no significant change with atorvastatin after 8weeks (p=0.145).	Pravastatin	71-82	microRNA 30c-1	Homo sapiens	57-64
28062296-11	2017	CONCLUSIONS: This study shows for the first-time in humans that circulating miR-30c is significantly, positively correlated with total- and LDL-cholesterol implicating regulatory functions in lipid homeostasis.	Cholesterol	144-155	microRNA 30c-1	Homo sapiens	76-83
28062296-12	2017	We show miR-30c is transported in both exosomes and on HDL3 and pravastatin therapy significantly increased circulating miR-30c expression adding to the pleiotropic dimensions of statins.	Pravastatin	64-75	microRNA 30c-1	Homo sapiens	8-15
28062296-12	2017	We show miR-30c is transported in both exosomes and on HDL3 and pravastatin therapy significantly increased circulating miR-30c expression adding to the pleiotropic dimensions of statins.	Pravastatin	64-75	microRNA 30c-1	Homo sapiens	120-127
28203091-6	2017	miR-30c also enhances the sensitivity of Caki-1 cells to anticancer agents, including sorafenib and paclitaxel.	Sorafenib	86-95	microRNA 30c-1	Homo sapiens	0-7
28203091-6	2017	miR-30c also enhances the sensitivity of Caki-1 cells to anticancer agents, including sorafenib and paclitaxel.	Paclitaxel	100-110	microRNA 30c-1	Homo sapiens	0-7