PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32157565-11	2020	Nevertheless, all of these cardioprotective effects of oestrogen receptor beta activation were almost abrogated by DAPT administration, i.e. DAPT attenuated the anti-oxidative and anti-apoptotic effects and the decrease in infarct and fibrotic areas and reversed cardiac functional recovery.	dapt	115-119	estrogen receptor 2 (beta)	Mus musculus	55-78
32703416-1	2020	Estrogen receptor beta (ERbeta), encoded by the Esr2 gene, is one of two nuclear receptors that mediate the functions of the steroid hormone estradiol.	Steroids	125-132	estrogen receptor 2 (beta)	Mus musculus	48-52
32703416-1	2020	Estrogen receptor beta (ERbeta), encoded by the Esr2 gene, is one of two nuclear receptors that mediate the functions of the steroid hormone estradiol.	Estradiol	141-150	estrogen receptor 2 (beta)	Mus musculus	48-52
32157565-11	2020	Nevertheless, all of these cardioprotective effects of oestrogen receptor beta activation were almost abrogated by DAPT administration, i.e. DAPT attenuated the anti-oxidative and anti-apoptotic effects and the decrease in infarct and fibrotic areas and reversed cardiac functional recovery.	dapt	141-145	estrogen receptor 2 (beta)	Mus musculus	55-78
31741264-10	2020	Meanwhile, the qRT-PCR results revealed that the LPS-induced upregulation of Ar mRNA in MLTC1 cells and Erbeta mRNA in TM4 cells were significantly recovered after treatment with the specific PPARgamma-antagonist GW9662.	2-chloro-5-nitrobenzanilide	213-219	estrogen receptor 2 (beta)	Mus musculus	104-110
31790664-2	2020	Therefore, the current study aimed to dissect the contribution of ERalpha and ERbeta to the effects of 17beta-estradiol under non-stress and chronic stress conditions.	Estradiol	103-119	estrogen receptor 2 (beta)	Mus musculus	78-84
31676226-7	2020	We found that 8mg/kg DPN (ERbeta-specific agonist) replacement therapy (3 weeks) to the ovariectomized (OVX) mice significantly reduced ischemia injury and alleviated microglia and astrocyte activation, and markedly inhibited the expression of NF-kappaB and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	NAD	21-24	estrogen receptor 2 (beta)	Mus musculus	26-32
31614180-9	2020	Additionally, the timing of calciotropic receptor appearance was confronted with that of estrogen receptors (ESR1, ESR2).	Estrogens	89-97	estrogen receptor 2 (beta)	Mus musculus	115-119
31586450-9	2019	E2 application can still mimicked the protective function when estrogen receptor alpha and beta (ERalpha and ERbeta) blocked by tamoxifen (TAM), while the effects was blocked by GPER1 antagonist G-15.	Tamoxifen	128-137	estrogen receptor 2 (beta)	Mus musculus	109-115
31586450-9	2019	E2 application can still mimicked the protective function when estrogen receptor alpha and beta (ERalpha and ERbeta) blocked by tamoxifen (TAM), while the effects was blocked by GPER1 antagonist G-15.	Tamoxifen	139-142	estrogen receptor 2 (beta)	Mus musculus	109-115
31565219-7	2019	Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice.	Pyruvates	111-119	estrogen receptor 2 (beta)	Mus musculus	192-198
31696058-0	2019	Cyanidin-3-o-Glucoside Pharmacologically Inhibits Tumorigenesis via Estrogen Receptor beta in Melanoma Mice.	cyanidin-3-o-glucoside	0-22	estrogen receptor 2 (beta)	Mus musculus	68-90
31565219-7	2019	Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice.	Pyruvates	142-150	estrogen receptor 2 (beta)	Mus musculus	192-198
31565219-8	2019	The findings indicated for the first time that while estrogen regulates ERalpha and ERbeta expression in the uterus, ERalpha and ERbeta selectively regulate uterine glycolytic enzyme expression during glycolysis.	Estrogens	53-61	estrogen receptor 2 (beta)	Mus musculus	84-90
31250031-0	2019	Oestrogen receptor beta mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.	bisphenol A	48-59	estrogen receptor 2 (beta)	Mus musculus	0-23
31211961-9	2019	In the F3 generation, ancestral DEHP exposure decreased the expression of steroidogenic enzymes, PI3K factors, cell cycle regulators, apoptosis factors, Esr2, DNA methylation mediators, and the percentage of 5-mC compared to controls.	Diethylhexyl Phthalate	32-36	estrogen receptor 2 (beta)	Mus musculus	153-157
31250031-2	2019	Low doses of BPA modify pancreatic beta cell function and induce insulin resistance; some of these effects are mediated via activation of oestrogen receptors alpha (ERalpha) and beta (ERbeta).	bisphenol A	13-16	estrogen receptor 2 (beta)	Mus musculus	184-190
31250031-13	2019	Beta cells from ERbeta-/- mice did not present BPA-induced changes, suggesting that ERbeta mediates BPA"s effects in pancreatic islets.	bisphenol A	100-103	estrogen receptor 2 (beta)	Mus musculus	84-90
31250031-15	2019	CONCLUSIONS/INTERPRETATION: Our data suggest that BPA modulates the expression and function of Na+ and K+ channels via ERbeta in mouse pancreatic islets.	bisphenol A	50-53	estrogen receptor 2 (beta)	Mus musculus	119-125
31457100-5	2019	Knockdown of estrogen receptors ESR1 and ESR2 in primary osteoprogenitors and osteoclasts undergoing differentiation showed decreased coexpression of membrane-bound CD39 and CD73 and lower extracellular adenosine.	Adenosine	203-212	estrogen receptor 2 (beta)	Mus musculus	41-45
31442293-10	2019	Furthermore, in WT MEFs, E2 treatment repressed TNF-alpha-induced expression of iNOS protein and recovered by 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol (PHTPP), a selective ERbeta antagonist, treatment, but not in Nrf2 KO MEFs.	4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	110-182	estrogen receptor 2 (beta)	Mus musculus	204-210
30428773-11	2019	Moreover, treatment of endometriosis xenografts with GW4064 suppressed aromatase and ERbeta expression in nude mice.	GW 4064	53-59	estrogen receptor 2 (beta)	Mus musculus	85-91
31312012-8	2019	Experiments using pharmacological tools as well as DRG from ERbeta-/- mice indicate that this BPA effect involves ERalpha and phosphoinositide 3-kinase.	bisphenol A	94-97	estrogen receptor 2 (beta)	Mus musculus	60-66
31428228-4	2019	Estradiol had similar potencies in binding affinity at ERalpha and ERbeta, which caused widespread genetic and epigenetic effects.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	67-73
31297095-3	2019	Firstly, estradiol, via estrogen receptor beta (ERbeta), enhanced the phagocytic clearance of apoptotic cells, acting through increased production and release of the protein AnxA1.	Estradiol	9-18	estrogen receptor 2 (beta)	Mus musculus	24-46
31280197-1	2019	BACKGROUND/AIM: Perinatal diethylstilbestrol (DES) treatment induces the polyovular follicle containing two or more oocytes in a follicle of mouse ovary through estrogen receptor (ER) beta.	Diethylstilbestrol	26-44	estrogen receptor 2 (beta)	Mus musculus	161-188
31280197-1	2019	BACKGROUND/AIM: Perinatal diethylstilbestrol (DES) treatment induces the polyovular follicle containing two or more oocytes in a follicle of mouse ovary through estrogen receptor (ER) beta.	Diethylstilbestrol	46-49	estrogen receptor 2 (beta)	Mus musculus	161-188
31297095-3	2019	Firstly, estradiol, via estrogen receptor beta (ERbeta), enhanced the phagocytic clearance of apoptotic cells, acting through increased production and release of the protein AnxA1.	Estradiol	9-18	estrogen receptor 2 (beta)	Mus musculus	48-54
30992459-5	2019	Cell viability and survival assays using multiple epitope tagged ERbeta expressing established and primary GBM cells demonstrated that ERbeta sensitizes GBM cells to DNA damaging agents including temozolomide (TMZ).	Temozolomide	196-208	estrogen receptor 2 (beta)	Mus musculus	135-141
31040210-8	2019	ERbeta-ligand treatment in the cuprizone model further increased cholesterol synthesis gene expression and enhanced remyelination.	Cuprizone	31-40	estrogen receptor 2 (beta)	Mus musculus	0-6
31040210-8	2019	ERbeta-ligand treatment in the cuprizone model further increased cholesterol synthesis gene expression and enhanced remyelination.	Cholesterol	65-76	estrogen receptor 2 (beta)	Mus musculus	0-6
31040210-9	2019	Conditional KOs of ERbeta in OLCs demonstrated that increased cholesterol-synthesis gene expression in OLCs was mediated by direct effects in both models.	Cholesterol	62-73	estrogen receptor 2 (beta)	Mus musculus	19-25
31040210-10	2019	To address this direct effect, ChIP assays showed binding of ERbeta to the putative estrogen-response element of a key cholesterol-synthesis gene (Fdps).	Cholesterol	119-130	estrogen receptor 2 (beta)	Mus musculus	61-67
30992459-5	2019	Cell viability and survival assays using multiple epitope tagged ERbeta expressing established and primary GBM cells demonstrated that ERbeta sensitizes GBM cells to DNA damaging agents including temozolomide (TMZ).	Temozolomide	210-213	estrogen receptor 2 (beta)	Mus musculus	135-141
30992459-7	2019	Gene set enrichment analysis (GSEA) suggested that ERbeta-modulated genes were correlated negatively with homologous recombination, mismatch repair and G2M checkpoint genes.	gsea	30-34	estrogen receptor 2 (beta)	Mus musculus	51-57
30992459-9	2019	Additionally, ERbeta overexpressing cells had a higher number of gammaH2AX foci following TMZ treatment.	Temozolomide	90-93	estrogen receptor 2 (beta)	Mus musculus	14-20
30992459-12	2019	ERbeta overexpression further enhanced the survival of mice to TMZ therapy in both TMZ sensitive and TMZ resistant GBM models.	Temozolomide	63-66	estrogen receptor 2 (beta)	Mus musculus	0-6
30992459-12	2019	ERbeta overexpression further enhanced the survival of mice to TMZ therapy in both TMZ sensitive and TMZ resistant GBM models.	Temozolomide	83-86	estrogen receptor 2 (beta)	Mus musculus	0-6
30992459-12	2019	ERbeta overexpression further enhanced the survival of mice to TMZ therapy in both TMZ sensitive and TMZ resistant GBM models.	Temozolomide	83-86	estrogen receptor 2 (beta)	Mus musculus	0-6
30684567-5	2019	Results showed that arsenic increased the expression levels of mRNA and protein of ERbeta, ERK1/2 and NF-kappaB/P65, and ICI182780 inhibited the increase.	Arsenic	20-27	estrogen receptor 2 (beta)	Mus musculus	83-89
30152543-7	2019	Estradiol, through estrogen receptor beta, released CTBP1 from CYP19A1 promoter triggering its transcription and modulating PCa cell proliferation.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	19-41
30679747-0	2019	Analogues of ERbeta ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis.	chloroindazole	27-41	estrogen receptor 2 (beta)	Mus musculus	13-19
30863326-2	2019	Estradiol exert its effects primarily through binding on the two classical estrogen receptor subtypes, alpha (ERalpha) and beta (ERbeta).	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	129-135
30863326-10	2019	Lack of Esr2 gene in male mice was associated with decreased sucrose preference following inescapable shock, suggesting susceptibility for development of anhedonia following stress.	Sucrose	61-68	estrogen receptor 2 (beta)	Mus musculus	8-12
30728084-3	2019	The steroid hormone 17beta-estradiol, along with its receptors ERalpha and ERbeta, is thought to be crucial for sex differences and is expected to be protective, but this may not hold true for males.	Steroids	4-19	estrogen receptor 2 (beta)	Mus musculus	75-81
30728084-3	2019	The steroid hormone 17beta-estradiol, along with its receptors ERalpha and ERbeta, is thought to be crucial for sex differences and is expected to be protective, but this may not hold true for males.	Estradiol	20-36	estrogen receptor 2 (beta)	Mus musculus	75-81
30679747-9	2019	Thus, the o-Methyl and o-Chloro IndCl analogues represent a class of ERbeta ligands that offer significant remyelination and neuroprotection as well as modulation of the immune system; hence, they appear appropriate to consider further for therapeutic development in multiple sclerosis and other demyelinating diseases.	o-methyl	10-18	estrogen receptor 2 (beta)	Mus musculus	69-75
30679747-9	2019	Thus, the o-Methyl and o-Chloro IndCl analogues represent a class of ERbeta ligands that offer significant remyelination and neuroprotection as well as modulation of the immune system; hence, they appear appropriate to consider further for therapeutic development in multiple sclerosis and other demyelinating diseases.	o-chloro indcl	23-37	estrogen receptor 2 (beta)	Mus musculus	69-75
30391483-2	2019	An Erbitux-conjugated TSML (Erb-TSML) was encapsulated with doxorubicin and gold nanorods conjugated with manganese-doped magnetism-engineered iron oxide nanoparticles, for theranostic applications of EGFR-positive tumors.	Doxorubicin	60-71	estrogen receptor 2 (beta)	Mus musculus	3-6
30342056-3	2019	METHODS: For clinical relevance, non-ovariectomized female mice were subjected to high fat diet together with pharmacological (DIP - 4-(2-(3,5-dimethylisoxazol-4-yl)-1H-indol-3-yl)phenol) interventions to ERbeta selective activation.	dip - 4-(2-(3,5-dimethylisoxazol-4-yl)-1h-indol-3-yl)phenol	127-186	estrogen receptor 2 (beta)	Mus musculus	205-211
30342056-6	2019	RESULTS: HFD-fed females treated with DIP had a tissue-specific response towards ERbeta selective activation.	3,5-diisopropylsalicylic acid	38-41	estrogen receptor 2 (beta)	Mus musculus	81-87
31663350-1	2019	AIM: Tamoxifen engages mitochondrial estrogen receptor beta as an antagonist, increases mitochondrial cytotoxicity and induces tumor cell death.	Tamoxifen	5-14	estrogen receptor 2 (beta)	Mus musculus	37-59
30201537-3	2019	We found that ERalpha and/or ERbeta activation using their agonists (0.5 mg/kg E2, PPT or DPN) ameliorate memory impairment in the Morris water maze and Y-maze tests, increase hippocampal neurogenesis and prevent hippocampal apoptotic responses.	NAD	90-93	estrogen receptor 2 (beta)	Mus musculus	29-35
30391483-2	2019	An Erbitux-conjugated TSML (Erb-TSML) was encapsulated with doxorubicin and gold nanorods conjugated with manganese-doped magnetism-engineered iron oxide nanoparticles, for theranostic applications of EGFR-positive tumors.	Manganese	106-115	estrogen receptor 2 (beta)	Mus musculus	3-6
30391483-2	2019	An Erbitux-conjugated TSML (Erb-TSML) was encapsulated with doxorubicin and gold nanorods conjugated with manganese-doped magnetism-engineered iron oxide nanoparticles, for theranostic applications of EGFR-positive tumors.	ferric oxide	143-153	estrogen receptor 2 (beta)	Mus musculus	3-6
30445053-4	2019	We performed an in vivo experiment using an animal model of allergic airway inflammation using male BALB/c mice to confirm an increase in the proinflammatory response induced by propylpyrazoletriol (PPT), an ERalpha agonist, and diarylpropionitrile (DPN), an ERbeta agonist.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	178-197	estrogen receptor 2 (beta)	Mus musculus	259-265
30445053-4	2019	We performed an in vivo experiment using an animal model of allergic airway inflammation using male BALB/c mice to confirm an increase in the proinflammatory response induced by propylpyrazoletriol (PPT), an ERalpha agonist, and diarylpropionitrile (DPN), an ERbeta agonist.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	199-202	estrogen receptor 2 (beta)	Mus musculus	259-265
30405370-3	2018	It is well known that estrogen receptors (ERs), particularly ER alpha (ERalpha), mediate effects of aromatized testosterone, i.e., 17beta-estradiol, but precise role played by ER beta (ERbeta) is still unclear.	Estradiol	131-147	estrogen receptor 2 (beta)	Mus musculus	185-191
30591454-7	2019	Selective ERbeta agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile induced apoptosis in primary CLL cells and suppressed the growth of CLL-derived MEC1 cells.	2,3-bis(4-hydroxyphenyl)-propionitrile	25-64	estrogen receptor 2 (beta)	Mus musculus	10-16
30376877-7	2018	The improvement of heart function in HF mice treated with ERbeta agonist DPN was also associated with reduced cardiac fibrosis and increased cardiac angiogenesis, while the ERalpha agonist PPT had no significant effect on either cardiac fibrosis or angiogenesis.	diarylpropionitrile	73-76	estrogen receptor 2 (beta)	Mus musculus	58-64
29430617-6	2018	Reduced estrogen receptor beta (ERbeta) protein levels were found in the PFC of male mice following tunicamycin treatment.	Tunicamycin	100-111	estrogen receptor 2 (beta)	Mus musculus	8-30
29524300-0	2018	Estrogen receptor-beta of microglia underlies sexual differentiation of neuronal protection via ginsenosides in mice brain.	Ginsenosides	96-108	estrogen receptor 2 (beta)	Mus musculus	0-22
29939337-7	2018	In hypothalamic slices incubated in 100 nM E2 for 4 h, the AVPV-kisspeptin expression was significantly enhanced, which was inhibited by PFOS in a dose-dependent manner or estrogen receptor alpha (ERalpha) antagonist MPP, but not ERbeta antagonist PHTPP.	perfluorooctane sulfonic acid	137-141	estrogen receptor 2 (beta)	Mus musculus	230-236
30081203-7	2018	In addition, the expression of the estrogen receptor-beta on the surface of mast cells was increased by tranexamic acid.	Tranexamic Acid	104-119	estrogen receptor 2 (beta)	Mus musculus	35-57
30081203-9	2018	Furthermore, this ameliorative effect on photoaging may be due to an increase in estrogen receptor-beta after tranexamic acid treatment.	Tranexamic Acid	110-125	estrogen receptor 2 (beta)	Mus musculus	81-103
30096284-3	2018	We found that ERalpha and/or ERbeta activation using their agonists (0.5 mg/kg E2, PPT or DPN) ameliorate memory impairment in the Morris water maze (MWM) and Y-maze tests and suppress apoptosis as evidenced by decreased caspase-3 activity and increased ratio of Bcl-2/Bax.	NAD	90-93	estrogen receptor 2 (beta)	Mus musculus	29-35
29430617-6	2018	Reduced estrogen receptor beta (ERbeta) protein levels were found in the PFC of male mice following tunicamycin treatment.	Tunicamycin	100-111	estrogen receptor 2 (beta)	Mus musculus	32-38
29430617-7	2018	Pretreatment with an ERbeta specific agonist, ERB-041 significantly attenuated tunicamycin-induced deficits in social behavior, and activation of IRE1/XBP1 pathway in mouse PFC.	Tunicamycin	79-90	estrogen receptor 2 (beta)	Mus musculus	21-27
29430617-7	2018	Pretreatment with an ERbeta specific agonist, ERB-041 significantly attenuated tunicamycin-induced deficits in social behavior, and activation of IRE1/XBP1 pathway in mouse PFC.	Tunicamycin	79-90	estrogen receptor 2 (beta)	Mus musculus	46-49
29430617-8	2018	Moreover, ERB-041 inhibited tunicamycin-induced increases in functional connectivity between PFC and hippocampus in male mice.	Tunicamycin	28-39	estrogen receptor 2 (beta)	Mus musculus	10-13
28948468-0	2018	Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.	tibolone	0-8	estrogen receptor 2 (beta)	Mus musculus	123-145
29684419-6	2018	Interruption of ERbeta/c-MET or ERbeta/IL-1/c-MET signaling via ERbeta-shRNA, IL-1 antagonist, or the c-MET inhibitor, SU11274, could partially reverse the T cell-enhanced BCa cell invasion and proliferation.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	119-126	estrogen receptor 2 (beta)	Mus musculus	16-22
29684419-6	2018	Interruption of ERbeta/c-MET or ERbeta/IL-1/c-MET signaling via ERbeta-shRNA, IL-1 antagonist, or the c-MET inhibitor, SU11274, could partially reverse the T cell-enhanced BCa cell invasion and proliferation.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	119-126	estrogen receptor 2 (beta)	Mus musculus	32-38
29684419-6	2018	Interruption of ERbeta/c-MET or ERbeta/IL-1/c-MET signaling via ERbeta-shRNA, IL-1 antagonist, or the c-MET inhibitor, SU11274, could partially reverse the T cell-enhanced BCa cell invasion and proliferation.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	119-126	estrogen receptor 2 (beta)	Mus musculus	32-38
29783074-12	2018	A high dose of FRBI (30 mg/kg to 40 mg/kg) could suppress ovarian and follicular development, and attenuate expression levels of ERbeta and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production.	frbi	15-19	estrogen receptor 2 (beta)	Mus musculus	129-135
30079374-8	2018	These results indicate that estradiol acts directly on GnRH neurons via the ERbeta/Akt/nNOS pathway at proestrus afternoon generating NO that retrogradely accelerates GABA and glutamate release from the presynaptic terminals contacting GnRH neurons.	Estradiol	28-37	estrogen receptor 2 (beta)	Mus musculus	76-82
30079374-8	2018	These results indicate that estradiol acts directly on GnRH neurons via the ERbeta/Akt/nNOS pathway at proestrus afternoon generating NO that retrogradely accelerates GABA and glutamate release from the presynaptic terminals contacting GnRH neurons.	gamma-Aminobutyric Acid	167-171	estrogen receptor 2 (beta)	Mus musculus	76-82
30079374-8	2018	These results indicate that estradiol acts directly on GnRH neurons via the ERbeta/Akt/nNOS pathway at proestrus afternoon generating NO that retrogradely accelerates GABA and glutamate release from the presynaptic terminals contacting GnRH neurons.	Glutamic Acid	176-185	estrogen receptor 2 (beta)	Mus musculus	76-82
30099673-1	2018	Diarylpropionitrile (DPN) is an estrogen receptor-beta-specific agonist that has been linked to neuroprotection, preserving cognitive function with age, the suppression of anxiety-like behaviors, inhibition of cancer growth, and other positive properties.	diarylpropionitrile	0-19	estrogen receptor 2 (beta)	Mus musculus	32-54
30099673-1	2018	Diarylpropionitrile (DPN) is an estrogen receptor-beta-specific agonist that has been linked to neuroprotection, preserving cognitive function with age, the suppression of anxiety-like behaviors, inhibition of cancer growth, and other positive properties.	diarylpropionitrile	21-24	estrogen receptor 2 (beta)	Mus musculus	32-54
29633601-2	2018	The present study was conducted in order to evaluate the (R)-(+) PGN-induced alterations in ovarian aromatization, proto-oncogenes and estrogen receptoralpha ( ERalpha) and ERbeta receptors expressions.	pulegone	65-68	estrogen receptor 2 (beta)	Mus musculus	173-179
29633601-6	2018	RESULTS: The PGN reduced Eralpha, Erbeta and Cyp19 expression at 50 mg/kg and 100 mg/kg doses, while significantly elevating p53 and reducing Bcl-2 expression.	pulegone	13-16	estrogen receptor 2 (beta)	Mus musculus	34-40
29679753-7	2018	DRIA-induced suppression was reversed by inhibition of the estrogen receptor (ER)beta by an antagonist, PHTPP, or by ERbeta siRNA (P < 0.05), but not by MPP, an ERalpha antagonist.	PHTPP	104-109	estrogen receptor 2 (beta)	Mus musculus	59-85
30003164-8	2018	BPA-exposed California mice showed increased hypothalamic expression of Kiss1, Esr1 and Esr2 relative to AIN control and EE-exposed parents in the case of Esr2.	bisphenol A	0-3	estrogen receptor 2 (beta)	Mus musculus	88-92
30003164-8	2018	BPA-exposed California mice showed increased hypothalamic expression of Kiss1, Esr1 and Esr2 relative to AIN control and EE-exposed parents in the case of Esr2.	bisphenol A	0-3	estrogen receptor 2 (beta)	Mus musculus	155-159
29704544-7	2018	BP-3-induced apoptosis and neurotoxicity were accompanied by decreases in the mRNA and protein expression levels of ESR1 and ESR2 (also known as ERalpha and ERbeta), with a simultaneous increase in GPER1 (also known as GPR30) expression.	oxybenzone	0-4	estrogen receptor 2 (beta)	Mus musculus	125-129
29704544-7	2018	BP-3-induced apoptosis and neurotoxicity were accompanied by decreases in the mRNA and protein expression levels of ESR1 and ESR2 (also known as ERalpha and ERbeta), with a simultaneous increase in GPER1 (also known as GPR30) expression.	oxybenzone	0-4	estrogen receptor 2 (beta)	Mus musculus	157-163
29704544-10	2018	In addition, BP-3 caused hypermethylation of the genes Esr1, Esr2 and Bcl2, which could explain the reduced mRNA and protein levels of the estrogen receptors.	oxybenzone	13-17	estrogen receptor 2 (beta)	Mus musculus	61-65
28948468-0	2018	Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.	Palmitic Acid	80-93	estrogen receptor 2 (beta)	Mus musculus	123-145
28948468-7	2018	Furthermore, estrogen receptor beta (ERbeta) inhibition partially dampened tibolone"s protective actions in BV-2 cells stimulated with palmitic acid.	tibolone	75-83	estrogen receptor 2 (beta)	Mus musculus	13-35
28948468-7	2018	Furthermore, estrogen receptor beta (ERbeta) inhibition partially dampened tibolone"s protective actions in BV-2 cells stimulated with palmitic acid.	tibolone	75-83	estrogen receptor 2 (beta)	Mus musculus	37-43
28948468-7	2018	Furthermore, estrogen receptor beta (ERbeta) inhibition partially dampened tibolone"s protective actions in BV-2 cells stimulated with palmitic acid.	Palmitic Acid	135-148	estrogen receptor 2 (beta)	Mus musculus	13-35
28948468-7	2018	Furthermore, estrogen receptor beta (ERbeta) inhibition partially dampened tibolone"s protective actions in BV-2 cells stimulated with palmitic acid.	Palmitic Acid	135-148	estrogen receptor 2 (beta)	Mus musculus	37-43
28948468-8	2018	In conclusion, tibolone protects BV-2 cells by a mechanism involving ERbeta and upregulation of neuroglobin.	tibolone	15-23	estrogen receptor 2 (beta)	Mus musculus	69-75
29550215-5	2018	We also demonstrate that an estrogen receptor beta (ERbeta) antagonist inhibits MPT and knockout of ERbeta decreases the sensitivity of mitochondria to the CypD inhibitor, cyclosporine A.	Cyclosporine	172-186	estrogen receptor 2 (beta)	Mus musculus	100-106
29550215-9	2018	We find that previously described interaction between the oligomycin sensitivity-conferring subunit of ATPase (OSCP) and CypD is decreased by ERbeta knockout, suggesting that ERbeta modulates MPT by regulating CypD interaction with OSCP.	Oligomycins	58-68	estrogen receptor 2 (beta)	Mus musculus	142-148
29550215-9	2018	We find that previously described interaction between the oligomycin sensitivity-conferring subunit of ATPase (OSCP) and CypD is decreased by ERbeta knockout, suggesting that ERbeta modulates MPT by regulating CypD interaction with OSCP.	Oligomycins	58-68	estrogen receptor 2 (beta)	Mus musculus	175-181
29550215-10	2018	Functionally, in primary neurons and hippocampal slice cultures, modulation of ERbeta has protective effects against glutamate toxicity and oxygen glucose deprivation, respectively.	Glutamic Acid	117-126	estrogen receptor 2 (beta)	Mus musculus	79-85
29730190-1	2018	Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor beta and aryl hydrocarbon receptor.	7-isopentenyloxycoumarin	30-54	estrogen receptor 2 (beta)	Mus musculus	229-251
29760072-4	2018	Since the estrogen receptor beta (ERbeta) is expressed in enteric glial cells and neurons, we investigated whether a selective ERbeta agonist, LY3201, can influence neuronal and glial cell differentiation.	LY3201	143-149	estrogen receptor 2 (beta)	Mus musculus	127-133
29730190-1	2018	Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor beta and aryl hydrocarbon receptor.	Coumarins	20-29	estrogen receptor 2 (beta)	Mus musculus	229-251
29730190-1	2018	Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor beta and aryl hydrocarbon receptor.	aurapten	56-65	estrogen receptor 2 (beta)	Mus musculus	229-251
29730190-1	2018	Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor beta and aryl hydrocarbon receptor.	umbelliprenin	71-84	estrogen receptor 2 (beta)	Mus musculus	229-251
29730190-1	2018	Naturally occurring coumarins 7-isopentenyloxycoumarin, auraptene, and umbelliprenin are able to modulate the biosynthesis of melanin in murine Melan-a cells probably through the interaction with selected biological targets like estrogen receptor beta and aryl hydrocarbon receptor.	Melanins	126-133	estrogen receptor 2 (beta)	Mus musculus	229-251
29481981-2	2018	Herein we treated ovariectomized mice with ERalpha or ERbeta selective agonist followed by thyroglobulin-immunization to induce experimental autoimmune thyroiditis (EAT), and observed the aggravation of EAT after diarylpropionitrile (DPN, ERbeta selective agonist) administration.	diarylpropionitrile	213-232	estrogen receptor 2 (beta)	Mus musculus	54-60
29481981-2	2018	Herein we treated ovariectomized mice with ERalpha or ERbeta selective agonist followed by thyroglobulin-immunization to induce experimental autoimmune thyroiditis (EAT), and observed the aggravation of EAT after diarylpropionitrile (DPN, ERbeta selective agonist) administration.	diarylpropionitrile	234-237	estrogen receptor 2 (beta)	Mus musculus	54-60
29294029-0	2018	Estrogen Receptor beta in the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice.	Cocaine	86-93	estrogen receptor 2 (beta)	Mus musculus	0-22
29277538-8	2018	Dual treatment with sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of glutathione levels, and prevention of PPK in female Krt16-/- mice.	sulforaphane	20-32	estrogen receptor 2 (beta)	Mus musculus	61-83
29277538-8	2018	Dual treatment with sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of glutathione levels, and prevention of PPK in female Krt16-/- mice.	diarylpropionitrile	37-56	estrogen receptor 2 (beta)	Mus musculus	61-83
30014635-1	2018	OBJECTIVE: To determine the effects of arsenic and estrogen receptor antagonist (ICI182, 780) on the expression of estrogen receptor beta (ERbeta) in alveolar II epithelial cells (AECII) of female and male mice.	Arsenic	39-46	estrogen receptor 2 (beta)	Mus musculus	115-137
30014635-1	2018	OBJECTIVE: To determine the effects of arsenic and estrogen receptor antagonist (ICI182, 780) on the expression of estrogen receptor beta (ERbeta) in alveolar II epithelial cells (AECII) of female and male mice.	Arsenic	39-46	estrogen receptor 2 (beta)	Mus musculus	139-145
29294029-4	2018	The purpose of this study was to determine if the estrogen receptors ERalpha and ERbeta regulate cocaine conditioned place preference in mice and whether they act in the nucleus accumbens, a brain region critically involved in the development of cocaine abuse.	Cocaine	97-104	estrogen receptor 2 (beta)	Mus musculus	81-87
29412683-6	2018	In summary, these studies highlight diosmetin as a novel therapeutic that induces apoptosis through estrogen receptor beta.	diosmetin	36-45	estrogen receptor 2 (beta)	Mus musculus	100-122
28357806-9	2018	Eralpha and Ppargamma agonists diminished, but Erbeta and Gpr30 agonists stimulated the BP-3-induced apoptotic and neurotoxic effects.	oxybenzone	88-92	estrogen receptor 2 (beta)	Mus musculus	47-53
28357806-13	2018	Therefore, we suggest that BP-3-evoked apoptosis of neuronal cells is mediated via attenuation of Eralpha/Ppargamma and stimulation of Erbeta/Gpr30 signaling.	oxybenzone	27-31	estrogen receptor 2 (beta)	Mus musculus	135-141
29175352-9	2018	D1 females treated with an agonist for ERalpha or ERbeta exhibited an antidepressant-like response to 1.5 mg/kg ketamine.	Ketamine	112-120	estrogen receptor 2 (beta)	Mus musculus	50-56
29175352-12	2018	CONCLUSION: Our results indicate that females" enhanced sensitivity to ketamine during Pro is likely mediated through estradiol acting on ERalpha and ERbeta, leading to greater activation of synaptic plasticity-related kinases within the PFC and HPC.	Ketamine	71-79	estrogen receptor 2 (beta)	Mus musculus	150-156
29309995-6	2018	17beta-estradiol, G-1, PPT, or ERbeta agonist DPN was infused directly into the medial amygdala of ovariectomized female mice.	NAD	46-49	estrogen receptor 2 (beta)	Mus musculus	31-37
29305887-0	2018	Estradiol enhances ethanol reward in female mice through activation of ERalpha and ERbeta.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	83-89
29294029-7	2018	Results: We found that mice treated with 17beta-estradiol or an ERbeta agonist exhibited increased cocaine conditioned place preference, while knockdown of ERbeta, but not ERalpha, in the nucleus accumbens of females with intact ovaries abrogated cocaine conditioned place preference.	Cocaine	99-106	estrogen receptor 2 (beta)	Mus musculus	64-70
29294029-7	2018	Results: We found that mice treated with 17beta-estradiol or an ERbeta agonist exhibited increased cocaine conditioned place preference, while knockdown of ERbeta, but not ERalpha, in the nucleus accumbens of females with intact ovaries abrogated cocaine conditioned place preference.	Cocaine	247-254	estrogen receptor 2 (beta)	Mus musculus	64-70
29294029-7	2018	Results: We found that mice treated with 17beta-estradiol or an ERbeta agonist exhibited increased cocaine conditioned place preference, while knockdown of ERbeta, but not ERalpha, in the nucleus accumbens of females with intact ovaries abrogated cocaine conditioned place preference.	Cocaine	247-254	estrogen receptor 2 (beta)	Mus musculus	156-162
29294029-9	2018	Conclusions: These data indicate that ERbeta in the nucleus accumbens regulates the development of cocaine conditioned place preference in female mice.	Cocaine	99-106	estrogen receptor 2 (beta)	Mus musculus	38-44
29294029-10	2018	17beta-Estradiol may activate neurons in the nucleus accumbens via ERbeta.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	67-73
29305887-0	2018	Estradiol enhances ethanol reward in female mice through activation of ERalpha and ERbeta.	Ethanol	19-26	estrogen receptor 2 (beta)	Mus musculus	83-89
29305887-4	2018	In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERalpha and ERbeta, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test.	Ethanol	131-138	estrogen receptor 2 (beta)	Mus musculus	120-126
29305887-5	2018	E2 enhanced ethanol CPP and, while specific activation of either receptor alone had no effect, co-activation of ERalpha and ERbeta also enhanced ethanol CPP, suggesting that E2 enhances ethanol reward in female mice through actions at both ERalpha and ERbeta.	Ethanol	145-152	estrogen receptor 2 (beta)	Mus musculus	124-130
29305887-5	2018	E2 enhanced ethanol CPP and, while specific activation of either receptor alone had no effect, co-activation of ERalpha and ERbeta also enhanced ethanol CPP, suggesting that E2 enhances ethanol reward in female mice through actions at both ERalpha and ERbeta.	Ethanol	145-152	estrogen receptor 2 (beta)	Mus musculus	124-130
28529128-2	2018	The primary physiological estrogen 17beta-estradiol (E2), a non-selective agonist of classical nuclear estrogen receptors (ERalpha and ERbeta) as well as the G protein-coupled estrogen receptor (GPER), stimulates formation of the vasodilator nitric oxide (NO) in endothelial cells.	Estradiol	35-51	estrogen receptor 2 (beta)	Mus musculus	135-141
28886438-0	2017	Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor beta and increases skeletal muscle mass in young female mice.	daidzein	0-8	estrogen receptor 2 (beta)	Mus musculus	74-96
28159674-7	2018	Pharmacological and molecular evidence, along with results obtained in genetically modified mice, demonstrated that BPA, and its substitute BPS, are potent estrogens acting at nanomolar concentrations via extranuclear ERalpha, ERbeta, and GPER.	bisphenol A	116-119	estrogen receptor 2 (beta)	Mus musculus	227-233
29253565-8	2018	Effects of DHCA on BMP-2-induced osteoblastogenesis were reduced when cells were treated with a specific siRNA to ERalpha or ERbeta.	dehydrodiconiferyl alcohol	11-15	estrogen receptor 2 (beta)	Mus musculus	125-131
29288734-0	2018	17beta-estradiol (E2) promotes growth and stability of new dendritic spines via estrogen receptor beta pathway in intact mouse cortex.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	80-102
29288734-0	2018	17beta-estradiol (E2) promotes growth and stability of new dendritic spines via estrogen receptor beta pathway in intact mouse cortex.	Estradiol	18-20	estrogen receptor 2 (beta)	Mus musculus	80-102
29288734-7	2018	Our results also indicate that the activation of the estrogen receptor beta (ERbeta) mimics the effects of E2 administration on spine dynamics.	Estradiol	107-109	estrogen receptor 2 (beta)	Mus musculus	53-75
29288734-7	2018	Our results also indicate that the activation of the estrogen receptor beta (ERbeta) mimics the effects of E2 administration on spine dynamics.	Estradiol	107-109	estrogen receptor 2 (beta)	Mus musculus	77-83
30357742-4	2018	Because ERbeta is localized in mitochondria, and because estradiol and ERbeta agonist increase mitochondrial O2 consumption, we assessed the mitochondrial respiration (with a high-resolution oxygraph system) and the in vitro activity of the complex I of the electron transfer chain in samples of brain cortex in aged wild-type and ERbetaKO female mice.	Oxygen	109-111	estrogen receptor 2 (beta)	Mus musculus	71-77
29975924-6	2018	RESULTS: We showed that ALA treatment significantly reduced the atherosclerosis induced by ovariectomy and high fat diet in the Ldlr-/- mouse model and restored expression of estrogen receptors (ERalpha and ERbeta), which reduced the progression of atherosclerosis.	Thioctic Acid	24-27	estrogen receptor 2 (beta)	Mus musculus	207-213
29275294-1	2018	BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) beta, not ERalpha.	Diethylstilbestrol	25-43	estrogen receptor 2 (beta)	Mus musculus	155-182
29275294-1	2018	BACKGROUND/AIM: Neonatal diethylstilbestrol (DES) treatment induces polyovular follicles (PFs), which contain more than two oocytes in a follicle, through estrogen receptor (ER) beta, not ERalpha.	Diethylstilbestrol	45-48	estrogen receptor 2 (beta)	Mus musculus	155-182
29275294-2	2018	2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) is a specific ERbeta agonist; the effects of neonatal DPN exposure on PF induction and gene expression in the mouse ovary were examined.	2,3-bis(4-hydroxyphenyl)-propionitrile	0-38	estrogen receptor 2 (beta)	Mus musculus	59-65
29275294-2	2018	2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) is a specific ERbeta agonist; the effects of neonatal DPN exposure on PF induction and gene expression in the mouse ovary were examined.	NAD	40-43	estrogen receptor 2 (beta)	Mus musculus	59-65
29275294-6	2018	CONCLUSION: Since SF1 is an important transcription factor of several genes involved in ovarian function, up-regulation of Sf1 expression by neonatal exposure to DPN, through ERbeta, might affect expression of Gdf9, Mis and Star, resulting in increased PFs in mouse ovary.	NAD	162-165	estrogen receptor 2 (beta)	Mus musculus	175-181
28886438-3	2017	Daidzein is one of the main isoflavones in soy, and activates ERbeta-dependent transcription.	daidzein	0-8	estrogen receptor 2 (beta)	Mus musculus	62-68
28886438-3	2017	Daidzein is one of the main isoflavones in soy, and activates ERbeta-dependent transcription.	Isoflavones	28-39	estrogen receptor 2 (beta)	Mus musculus	62-68
28886438-5	2017	Daidzein stimulated the transcriptional activity of ERbeta in murine C2C12 cells and down-regulated USP19 expression.	daidzein	0-8	estrogen receptor 2 (beta)	Mus musculus	52-58
28886438-7	2017	Daidzein inhibited E2-induced recruitment of ERalpha and promoted recruitment of ERbeta to the Usp19 hERE.	daidzein	0-8	estrogen receptor 2 (beta)	Mus musculus	81-87
28886438-10	2017	Furthermore, E2 induced the recruitment of ERalpha and ERbeta to the hERE, whereas daidzein inhibited E2-induced recruitment of ERalpha, and enhanced E2-increased recruitment of ERbeta, to the Usp19 hERE.	daidzein	83-91	estrogen receptor 2 (beta)	Mus musculus	178-184
28924161-5	2017	Using mouse pancreatic beta-cells from wild-type and oestrogen receptor ERbeta-/- mice, we found that exposure to increasing doses of BPA affected Ca2+ entry in an NMDR manner.	bisphenol A	134-137	estrogen receptor 2 (beta)	Mus musculus	72-78
28846921-12	2017	The findings also indirectly support a role for ERalpha and ERbeta in mediating the memory-enhancing effects of hippocampally-synthesized E2.	Estradiol	138-140	estrogen receptor 2 (beta)	Mus musculus	60-66
28903498-11	2017	We conclude that lifelong exposure to BPA or BPS augmented the monocyte/macrophage inflammatory response and adverse remodeling from an MI thereby reducing the ability to survive and successfully recover, and that the adverse effect of BPA, but not BPS, is downstream of ERbeta signaling.	bisphenol A	38-41	estrogen receptor 2 (beta)	Mus musculus	271-277
28903498-11	2017	We conclude that lifelong exposure to BPA or BPS augmented the monocyte/macrophage inflammatory response and adverse remodeling from an MI thereby reducing the ability to survive and successfully recover, and that the adverse effect of BPA, but not BPS, is downstream of ERbeta signaling.	bis(4-hydroxyphenyl)sulfone	45-48	estrogen receptor 2 (beta)	Mus musculus	271-277
28903498-11	2017	We conclude that lifelong exposure to BPA or BPS augmented the monocyte/macrophage inflammatory response and adverse remodeling from an MI thereby reducing the ability to survive and successfully recover, and that the adverse effect of BPA, but not BPS, is downstream of ERbeta signaling.	bisphenol A	236-239	estrogen receptor 2 (beta)	Mus musculus	271-277
28627701-9	2017	Mangiferin may inhibit osteoclastic bone resorption by suppressing differentiation of osteoclasts and promoting expression of ERbeta mRNA in mouse bone marrow macrophage cells.	mangiferin	0-10	estrogen receptor 2 (beta)	Mus musculus	126-132
28809938-0	2017	Perinatal testosterone exposure potentiates vascular dysfunction by ERbeta suppression in endothelial progenitor cells.	Testosterone	10-22	estrogen receptor 2 (beta)	Mus musculus	68-74
28809938-2	2017	Our preliminary results showed that perinatal testosterone exposure in mice induces estrogen receptor beta (ERbeta) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect.	Testosterone	46-58	estrogen receptor 2 (beta)	Mus musculus	84-106
28809938-2	2017	Our preliminary results showed that perinatal testosterone exposure in mice induces estrogen receptor beta (ERbeta) suppression in endothelial progenitor cells (EPCs) in offspring but not mothers, while estradiol (E2) had no effect.	Testosterone	46-58	estrogen receptor 2 (beta)	Mus musculus	108-114
28809938-3	2017	Further investigation showed that ERbeta suppression is due to perinatal testosterone exposure-induced epigenetic changes with altered DNA methylation on the ERbeta promoter.	Testosterone	73-85	estrogen receptor 2 (beta)	Mus musculus	34-40
28809938-3	2017	Further investigation showed that ERbeta suppression is due to perinatal testosterone exposure-induced epigenetic changes with altered DNA methylation on the ERbeta promoter.	Testosterone	73-85	estrogen receptor 2 (beta)	Mus musculus	158-164
28809938-7	2017	We conclude that perinatal testosterone exposure potentiates vascular dysfunction through ERbeta suppression in EPCs.	Testosterone	27-39	estrogen receptor 2 (beta)	Mus musculus	90-96
28796245-10	2017	Collectively, these findings proved that dioscin exerted efficient anti-PCa activity via activation of ERbeta, which should be developed as an efficient candidate in clinical for treating this cancer in the future.	dioscin	41-48	estrogen receptor 2 (beta)	Mus musculus	103-109
28810592-6	2017	At 3 days after operation, echocardiographic posterior wall thickness at end diastole (PWTD) and end systolic PWTS of Tg-ERbeta mice were significantly reduced, and left ventricular systolic diameter and left ventricular diastolic diameter significantly increased (P<0.05) compared with NLC mice.	Thioguanine	118-120	estrogen receptor 2 (beta)	Mus musculus	121-127
28810592-8	2017	In conclusion, Tg-ERbeta exerts a protective effect on MI.	Thioguanine	15-17	estrogen receptor 2 (beta)	Mus musculus	18-24
28796245-0	2017	Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-beta.	dioscin	0-7	estrogen receptor 2 (beta)	Mus musculus	69-91
28796245-1	2017	Recent researches have shown that estrogen receptor-beta (ERbeta) activator may be a potent anticancer agent for prostate cancer (PCa), and our previous study also indicated that dioscin can upregulate the expression of ERbeta in MC3T3-E1 cell.	dioscin	179-186	estrogen receptor 2 (beta)	Mus musculus	34-56
28796245-1	2017	Recent researches have shown that estrogen receptor-beta (ERbeta) activator may be a potent anticancer agent for prostate cancer (PCa), and our previous study also indicated that dioscin can upregulate the expression of ERbeta in MC3T3-E1 cell.	dioscin	179-186	estrogen receptor 2 (beta)	Mus musculus	58-64
28796245-1	2017	Recent researches have shown that estrogen receptor-beta (ERbeta) activator may be a potent anticancer agent for prostate cancer (PCa), and our previous study also indicated that dioscin can upregulate the expression of ERbeta in MC3T3-E1 cell.	dioscin	179-186	estrogen receptor 2 (beta)	Mus musculus	220-226
28796245-6	2017	Furthermore, mechanism investigation showed that dioscin markedly upregulated ERbeta expression level, subsequently increased prolyl hydroxylase 2 level, decreased the levels of hypoxia-inducible factor-1alpha, vascular endothelial growth factor A and BMI-1, and thus induced cell apoptosis by regulating the expression levels of caspase-3 and Bcl-2 family proteins.	dioscin	49-56	estrogen receptor 2 (beta)	Mus musculus	78-84
28796245-7	2017	In addition, transfection experiment of ERbeta-siRNA further indicated that diosicn showed excellent activity against PCa in vitro and in vivo by increasing ERbeta expression level.	diosicn	76-83	estrogen receptor 2 (beta)	Mus musculus	40-46
28796245-7	2017	In addition, transfection experiment of ERbeta-siRNA further indicated that diosicn showed excellent activity against PCa in vitro and in vivo by increasing ERbeta expression level.	diosicn	76-83	estrogen receptor 2 (beta)	Mus musculus	157-163
28796245-8	2017	The co-immunoprecipitation (Co-IP) results further suggested that dioscin promoted the interaction of c-ABL and ERbeta, but did not change c-ABL expression.	dioscin	66-73	estrogen receptor 2 (beta)	Mus musculus	112-118
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	dioscin	50-57	estrogen receptor 2 (beta)	Mus musculus	96-102
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Hydrogen	129-137	estrogen receptor 2 (beta)	Mus musculus	96-102
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Hydrogen	129-137	estrogen receptor 2 (beta)	Mus musculus	201-207
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	dioscin	190-197	estrogen receptor 2 (beta)	Mus musculus	96-102
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	dioscin	190-197	estrogen receptor 2 (beta)	Mus musculus	201-207
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Phenylalanine	293-296	estrogen receptor 2 (beta)	Mus musculus	96-102
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Phenylalanine	293-296	estrogen receptor 2 (beta)	Mus musculus	201-207
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Phenylalanine	302-305	estrogen receptor 2 (beta)	Mus musculus	96-102
28796245-9	2017	Moreover, the molecular docking assay showed that dioscin processed powerful affinity toward to ERbeta mainly through the strong hydrogen bonding and hydrophobic effects, and the actions of dioscin on ERbeta activation and tumor cells inhibition were significantly weakened in the mutational (Phe-336, Phe-468) PC3 cells.	Phenylalanine	302-305	estrogen receptor 2 (beta)	Mus musculus	201-207
28670368-8	2017	Analysis of colony formation, migration, and invasion capacities, measured using soft agar colony-formation, wound-healing, and transwell invasion assays, respectively, showed that ERbeta silencing augments cell proliferation, migration, and invasion, and that this increase is reversed by PD98059 treatment.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	290-297	estrogen receptor 2 (beta)	Mus musculus	181-187
28706210-5	2017	The effect of E2 on aromatase expression was not imitated by oestrogen receptor (ER) alpha agonist PPT or the GPER agonist G1, but it was fully reproduced by DPN, a specific ligand of ERbeta.	NAD	158-161	estrogen receptor 2 (beta)	Mus musculus	184-190
28706210-6	2017	By contrast, the effect of DHT on aromatase expression was not blocked by the anti-androgen flutamide, but completely abrogated by the ERbeta antagonist PHTPP.	Dihydrotestosterone	27-30	estrogen receptor 2 (beta)	Mus musculus	135-141
28706210-6	2017	By contrast, the effect of DHT on aromatase expression was not blocked by the anti-androgen flutamide, but completely abrogated by the ERbeta antagonist PHTPP.	PHTPP	153-158	estrogen receptor 2 (beta)	Mus musculus	135-141
28263910-0	2017	Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.	DDT	47-50	estrogen receptor 2 (beta)	Mus musculus	139-143
28263910-7	2017	In contrast, o,p"-DDT did not induce depressive-like effects and exhibited quite distinct pattern of biochemical alterations that was related to aryl hydrocarbon receptor (AHR), its nuclear translocator ARNT, and ESR2.	o,p'-DDT	13-21	estrogen receptor 2 (beta)	Mus musculus	213-217
28263910-8	2017	Exposure to o,p"-DDT increased AHR expression in male and female brains, and reduced expression levels of ARNT and ESR2 in the female brains.	o,p'-DDT	12-20	estrogen receptor 2 (beta)	Mus musculus	115-119
29736382-5	2018	All doses of genistein decreased the expression of estrogen receptor-alpha, increased estrogen receptor-beta, lowered VEGF and HIF-1alpha significantly compared with endometriosis group (p > 0.05).	Genistein	13-22	estrogen receptor 2 (beta)	Mus musculus	86-108
28386898-0	2017	Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse.	perfluorooctane sulfonic acid	58-83	estrogen receptor 2 (beta)	Mus musculus	0-22
28386898-2	2017	In this study, we investigated the function of estrogen receptor beta (ERbeta) in PFOS-induced bile acid and cholesterol metabolism disorders and gut microbiome using ERbeta knockout mice that were exposed to PFOS by gavage.	perfluorooctane sulfonic acid	82-86	estrogen receptor 2 (beta)	Mus musculus	47-69
28386898-2	2017	In this study, we investigated the function of estrogen receptor beta (ERbeta) in PFOS-induced bile acid and cholesterol metabolism disorders and gut microbiome using ERbeta knockout mice that were exposed to PFOS by gavage.	perfluorooctane sulfonic acid	82-86	estrogen receptor 2 (beta)	Mus musculus	71-77
28386898-2	2017	In this study, we investigated the function of estrogen receptor beta (ERbeta) in PFOS-induced bile acid and cholesterol metabolism disorders and gut microbiome using ERbeta knockout mice that were exposed to PFOS by gavage.	Bile Acids and Salts	95-104	estrogen receptor 2 (beta)	Mus musculus	71-77
29736382-7	2018	It was concluded that genistein is able to modulate estrogen receptor-alpha and estrogen receptor-beta and inhibit the development of inflammation and angiogenesis in the murine model of peritoneal endometriosis.	Genistein	22-31	estrogen receptor 2 (beta)	Mus musculus	80-102
27903449-4	2017	Therefore, the goal of this study was to examine the role of estradiol - ERbeta signaling in mediating DOL effects in male mice to further decipher sex differences.	dalfopristin	103-106	estrogen receptor 2 (beta)	Mus musculus	73-79
28386898-8	2017	Our study thus provides new evidence that ERbeta mediates PFOS-induced hepatotoxicity.	perfluorooctane sulfonic acid	58-62	estrogen receptor 2 (beta)	Mus musculus	42-48
28266530-7	2017	The ESR2-selective agonist diarylpropionitrile did not affect steroidogenesis.	diarylpropionitrile	27-46	estrogen receptor 2 (beta)	Mus musculus	4-8
28266530-10	2017	In cultured PLCs, 17beta-estradiol, propylpyrazoletriol, and diarylpropionitrile reduced hCG-stimulated Ki67 and Pcna mRNA expression and the number of KI67-positive PLCs, suggesting that oestrogen inhibits PLC proliferation via both ESR1 and ESR2.	Estradiol	18-34	estrogen receptor 2 (beta)	Mus musculus	243-247
28266530-10	2017	In cultured PLCs, 17beta-estradiol, propylpyrazoletriol, and diarylpropionitrile reduced hCG-stimulated Ki67 and Pcna mRNA expression and the number of KI67-positive PLCs, suggesting that oestrogen inhibits PLC proliferation via both ESR1 and ESR2.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	36-55	estrogen receptor 2 (beta)	Mus musculus	243-247
28266530-10	2017	In cultured PLCs, 17beta-estradiol, propylpyrazoletriol, and diarylpropionitrile reduced hCG-stimulated Ki67 and Pcna mRNA expression and the number of KI67-positive PLCs, suggesting that oestrogen inhibits PLC proliferation via both ESR1 and ESR2.	diarylpropionitrile	61-80	estrogen receptor 2 (beta)	Mus musculus	243-247
28092182-0	2017	An estrogen receptor beta-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors.	Bile Acids and Salts	119-128	estrogen receptor 2 (beta)	Mus musculus	3-25
28013213-8	2017	One variant murine ERbeta was constitutively active when expressed in cholangiocytes, was readily inactivated by ICI182780 and activated in a dose-responsive, ICI182780-inhibitable manner by oestrogen.	Fulvestrant	113-122	estrogen receptor 2 (beta)	Mus musculus	19-25
27357538-4	2017	When treating mice grafted with either germinal center or activated B-cell like DLBCL cells with the selective estrogen receptor beta (ERbeta) agonist diarylpropionitrile, tumor growth was significantly inhibited.	diarylpropionitrile	151-170	estrogen receptor 2 (beta)	Mus musculus	111-133
27357538-4	2017	When treating mice grafted with either germinal center or activated B-cell like DLBCL cells with the selective estrogen receptor beta (ERbeta) agonist diarylpropionitrile, tumor growth was significantly inhibited.	diarylpropionitrile	151-170	estrogen receptor 2 (beta)	Mus musculus	135-141
28052027-7	2017	In nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice engrafted with HL cells, ERbeta activation by DPN was able to reduce lymphoma growth up to 60% and this associated with the induction of tumor cell autophagy.	NAD	115-118	estrogen receptor 2 (beta)	Mus musculus	94-100
27863380-7	2016	In colitis mice, the activation of ERbeta, inhibition of mTORC1 activation and Th17 response by arctigenin were abolished by PHTPP treatment.	PHTPP	125-130	estrogen receptor 2 (beta)	Mus musculus	35-41
27733447-6	2017	An ER-beta-selective ligand increased markers of tricarboxylic acid-dependent and -independent energy biogenesis and oxygen consumption in mice without a concomitant increase in physical activity or food consumption, all culminating in significantly reduced weight gain and adiposity.	Tricarboxylic Acids	49-67	estrogen receptor 2 (beta)	Mus musculus	3-10
27733447-6	2017	An ER-beta-selective ligand increased markers of tricarboxylic acid-dependent and -independent energy biogenesis and oxygen consumption in mice without a concomitant increase in physical activity or food consumption, all culminating in significantly reduced weight gain and adiposity.	Oxygen	117-123	estrogen receptor 2 (beta)	Mus musculus	3-10
27922125-4	2016	A 3-day-treatment with a selective ERbeta agonist, LY3201, induced browning of SAT in 1-year-old obese WT and ERalpha-/- female mice.	LY3201	51-57	estrogen receptor 2 (beta)	Mus musculus	35-41
27470296-4	2016	A single-mutant SIRT1-C152(D) restored the reduced ERbeta expression in the endothelium with minimized reactive oxygen species generation and DNA damage and increased mitochondrial function and fatty acid metabolism.	Reactive Oxygen Species	103-126	estrogen receptor 2 (beta)	Mus musculus	51-57
27779914-9	2016	Mice lacking either aromatase or estrogen receptor-beta had hypertrophic Pps and mLNs with more leukocytes than their wild-type littermates, demonstrating a role for 17beta-estradiol in leukocyte regulation.	Estradiol	166-182	estrogen receptor 2 (beta)	Mus musculus	33-55
27194721-3	2016	Estrogen treatment of WT and ERbeta knockout (KO) mice caused a significant reduction in food intake along with increased renal phosphate wasting.	Phosphates	128-137	estrogen receptor 2 (beta)	Mus musculus	29-35
27922125-8	2016	The increase in both sympathetic tone and responsiveness of adipocytes to catecholamines reveals a novel role for ERbeta in controlling browning of adipose tissue.	Catecholamines	74-88	estrogen receptor 2 (beta)	Mus musculus	114-120
27549171-8	2016	Expression of the estrogen receptor beta by CD4(+) T cells was necessary for DHEA-mediated EAE amelioration, as well as for direct downregulation of Th17 responses.	Dehydroepiandrosterone	77-81	estrogen receptor 2 (beta)	Mus musculus	18-40
27581038-0	2017	Dibutyl Phthalate (DBP)-Induced Apoptosis and Neurotoxicity are Mediated via the Aryl Hydrocarbon Receptor (AhR) but not by Estrogen Receptor Alpha (ERalpha), Estrogen Receptor Beta (ERbeta), or Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) in Mouse Cortical Neurons.	Dibutyl Phthalate	0-17	estrogen receptor 2 (beta)	Mus musculus	183-189
27581038-0	2017	Dibutyl Phthalate (DBP)-Induced Apoptosis and Neurotoxicity are Mediated via the Aryl Hydrocarbon Receptor (AhR) but not by Estrogen Receptor Alpha (ERalpha), Estrogen Receptor Beta (ERbeta), or Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) in Mouse Cortical Neurons.	Dibutyl Phthalate	19-22	estrogen receptor 2 (beta)	Mus musculus	183-189
27250720-8	2016	Tibolone upregulated neuroglobin in T98G cells and primary mouse astrocytes by a mechanism involving ERbeta and neuroglobin silencing prevented the protective action of tibolone on GD cells.	tibolone	0-8	estrogen receptor 2 (beta)	Mus musculus	101-107
27688996-9	2016	17betaE blunted the response of both nonadapting GI and AdGI neurons to low glucose in both males and females, which was mediated by activation of estrogen receptor beta and inhibition of AMP-activated kinase.	Glucose	76-83	estrogen receptor 2 (beta)	Mus musculus	147-169
26911702-11	2016	Additionally, BPA exposure in utero decreased Esr1 receptor gene expression and increased Esr2 receptor gene expression.	bisphenol A	14-17	estrogen receptor 2 (beta)	Mus musculus	90-94
27037280-8	2016	Chelidonic acid administration significantly increased the mRNA expression of hippocampal estrogen receptor-beta.	chelidonic acid	0-15	estrogen receptor 2 (beta)	Mus musculus	90-112
27126081-0	2016	Selective Estrogen Receptor beta Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma.	erteberel	41-49	estrogen receptor 2 (beta)	Mus musculus	10-32
27105387-5	2016	Here, we have developed antisera for mouse ERbeta (mERbeta) using a specific C-terminal 18-amino acid peptide conjugated to mariculture keyhole limpet hemocyanin.	18-amino acid peptide	88-109	estrogen receptor 2 (beta)	Mus musculus	43-49
27105387-5	2016	Here, we have developed antisera for mouse ERbeta (mERbeta) using a specific C-terminal 18-amino acid peptide conjugated to mariculture keyhole limpet hemocyanin.	18-amino acid peptide	88-109	estrogen receptor 2 (beta)	Mus musculus	51-58
26873133-4	2016	We previously reported that ERalpha and ERbeta are involved in neuroprotection following MPTP toxicity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	89-93	estrogen receptor 2 (beta)	Mus musculus	40-46
27183630-4	2016	In this article, we show that the synthetic ERbeta-specific ligand 4-(2-phenyl-5,7-bis[trifluoromethyl]pyrazolo[1,5-a]pyrimidin-3-yl)phenol (PHTPP) reversed established paralysis and CNS inflammation, characterized by a dramatic suppression of pathogenic Th responses as well as induction of IL-10-producing regulatory CD4(+) T cell subsets in vivo.	4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	67-139	estrogen receptor 2 (beta)	Mus musculus	44-50
27183630-4	2016	In this article, we show that the synthetic ERbeta-specific ligand 4-(2-phenyl-5,7-bis[trifluoromethyl]pyrazolo[1,5-a]pyrimidin-3-yl)phenol (PHTPP) reversed established paralysis and CNS inflammation, characterized by a dramatic suppression of pathogenic Th responses as well as induction of IL-10-producing regulatory CD4(+) T cell subsets in vivo.	4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	141-146	estrogen receptor 2 (beta)	Mus musculus	44-50
27183630-6	2016	PHTPP-mediated experimental autoimmune encephalomyelitis amelioration was canceled in mice with ERbeta-deficient CD4(+) T cells only, indicating that expression of ERbeta by these cells is crucial for the observed therapeutic effect.	4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	0-5	estrogen receptor 2 (beta)	Mus musculus	96-102
26776441-4	2016	Our previous work has shown that therapeutic treatment with the modestly selective generic estrogen receptor (ER) beta agonist diarylpropionitrile (DPN) confers functional neuroprotection in a chronic experimental autoimmune encephalomyelitis (EAE) mouse model of MS by stimulating endogenous remyelination.	diarylpropionitrile	127-146	estrogen receptor 2 (beta)	Mus musculus	91-118
26776441-4	2016	Our previous work has shown that therapeutic treatment with the modestly selective generic estrogen receptor (ER) beta agonist diarylpropionitrile (DPN) confers functional neuroprotection in a chronic experimental autoimmune encephalomyelitis (EAE) mouse model of MS by stimulating endogenous remyelination.	diarylpropionitrile	148-151	estrogen receptor 2 (beta)	Mus musculus	91-118
26776441-5	2016	Recently, we found that the more potent, selective ERbeta agonist indazole-chloride (Ind-Cl) improves clinical disease and motor performance.	indazole-chloride	66-83	estrogen receptor 2 (beta)	Mus musculus	51-57
26776441-5	2016	Recently, we found that the more potent, selective ERbeta agonist indazole-chloride (Ind-Cl) improves clinical disease and motor performance.	ind-cl	85-91	estrogen receptor 2 (beta)	Mus musculus	51-57
27126081-4	2016	In the present study, we examined the therapeutic effect of the selective synthetic ERbeta agonist LY500307 using in vitro and in vivo GBM models.	erteberel	99-107	estrogen receptor 2 (beta)	Mus musculus	84-90
27126081-6	2016	ERbeta agonists promoted apoptosis of GBM cells, and mechanistic studies using RNA sequencing revealed that LY500307 modulated several pathways related to apoptosis, cell cycle, and DNA damage response.	erteberel	108-116	estrogen receptor 2 (beta)	Mus musculus	0-6
27358124-6	2016	MTT results demonstrated that the proliferation rate of osteoblast was lower after the joint interference than after ERbeta interference, while a slight increase was found in the proliferation rate after ERbeta interference in comparison with the blank control group.	monooxyethylene trimethylolpropane tristearate	0-3	estrogen receptor 2 (beta)	Mus musculus	117-123
27186315-11	2016	While the CORT levels were decreased by ICA at mid or high doses, the expressions of GR, ERalpha and ERbeta were up-regulated by estrogen or different doses of ICA in a dosedependent manner.	icariin	160-163	estrogen receptor 2 (beta)	Mus musculus	101-107
27186315-13	2016	In contrast, ICA at mid and high doses promoted ERbeta more significantly than estrogen.	icariin	13-16	estrogen receptor 2 (beta)	Mus musculus	48-54
27186315-14	2016	CONCLUSION: ICA exerts estrogen-like activity in ameliorating EAE via mediating ERbeta, modulating HPA function and up-regulating the expression of GR in cerebral white matter.	icariin	12-15	estrogen receptor 2 (beta)	Mus musculus	80-86
26944108-6	2016	BPA effect in 3T3-L1 cells was associated to the specific activation of the estrogen receptor alpha (ERalpha) in undifferentiated cells and the estrogen receptor beta (ERbeta) in differentiated cells.	bisphenol A	0-3	estrogen receptor 2 (beta)	Mus musculus	144-166
26944108-6	2016	BPA effect in 3T3-L1 cells was associated to the specific activation of the estrogen receptor alpha (ERalpha) in undifferentiated cells and the estrogen receptor beta (ERbeta) in differentiated cells.	bisphenol A	0-3	estrogen receptor 2 (beta)	Mus musculus	168-174
26944108-8	2016	The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes.	Diethylstilbestrol	35-53	estrogen receptor 2 (beta)	Mus musculus	242-248
26944108-8	2016	The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes.	Diethylstilbestrol	55-58	estrogen receptor 2 (beta)	Mus musculus	242-248
26944108-8	2016	The pure estrogen receptor agonist diethylstilbestrol (DES) played an opposite action to that of BPA inhibiting PPARgamma activity in adipocytes, preventing cell differentiation, activating ERalpha in preadipocytes and inhibiting ERalpha and ERbeta regulation in adipocytes.	bisphenol A	97-100	estrogen receptor 2 (beta)	Mus musculus	242-248
27066533-1	2016	Testosterone, after being converted to estradiol in the brain, acts on estrogen receptors (ERalpha and ERbeta) and controls the expression of male-type social behavior.	Testosterone	0-12	estrogen receptor 2 (beta)	Mus musculus	103-109
27066533-1	2016	Testosterone, after being converted to estradiol in the brain, acts on estrogen receptors (ERalpha and ERbeta) and controls the expression of male-type social behavior.	Estradiol	39-48	estrogen receptor 2 (beta)	Mus musculus	103-109
26631067-0	2016	Estradiol via estrogen receptor beta inhibits chondrogenesis of mouse vertebral growth plate in vitro.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	14-36
26998610-8	2016	The response is not mimicked by the application of the classical estrogen receptor agonists, PPT, (an ERalpha agonist) or DPN, (an ERbeta agonist), further suggesting that this effect of 17beta-Estradiol is mediated through the activation of GPER1.	Estradiol	187-203	estrogen receptor 2 (beta)	Mus musculus	131-137
26732685-9	2016	2,3-Bis(4-hydroxyphenyl)-propionitrile (ERbeta agonist), but not 4,4",4""-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (ERalpha agonist) or G1 (GPR30 agonist), inhibited microglial proliferation.	2,3-bis(4-hydroxyphenyl)-propionitrile	0-38	estrogen receptor 2 (beta)	Mus musculus	40-46
26631067-9	2016	In addition, the inhibitory effect of estradiol was reversed by ERbeta small interfering RNA (siRNA) or PHTPP, an ERbeta antagonist.	Estradiol	38-47	estrogen receptor 2 (beta)	Mus musculus	64-70
26631067-9	2016	In addition, the inhibitory effect of estradiol was reversed by ERbeta small interfering RNA (siRNA) or PHTPP, an ERbeta antagonist.	Estradiol	38-47	estrogen receptor 2 (beta)	Mus musculus	114-120
26631067-9	2016	In addition, the inhibitory effect of estradiol was reversed by ERbeta small interfering RNA (siRNA) or PHTPP, an ERbeta antagonist.	PHTPP	104-109	estrogen receptor 2 (beta)	Mus musculus	114-120
26631067-10	2016	CONCLUSIONS: Estradiol via estrogen/estrogen receptor beta axis inhibits the proliferation and differentiation of VGP chondrocytes, which might give some new insight into the regulatory mechanism of bone development.	Estradiol	13-22	estrogen receptor 2 (beta)	Mus musculus	36-58
26891996-5	2016	In astrocytes, 2.5-20 nM 17beta-estradiol (E2) or 10 nM DPN (ERbeta agonist) not 10 nM PPT (ERalpha agonist), significantly increased GFAP expression.	NAD	56-59	estrogen receptor 2 (beta)	Mus musculus	61-67
26889208-11	2016	We also show that ERbeta is recruited to regions around hypermethylated DMPs.	Unithiol	72-76	estrogen receptor 2 (beta)	Mus musculus	18-24
26889208-12	2016	Finally, we demonstrate here that ERbeta interacts with TDG and that TDG binds ERbeta-dependently to hypermethylated DMPs.	Unithiol	117-121	estrogen receptor 2 (beta)	Mus musculus	79-85
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	estrogen receptor 2 (beta)	Mus musculus	194-216
26836767-2	2016	The aim of this study was to investigate the contribution of neural estrogen receptor (ER) beta in estradiol-induced effects without interfering with its peripheral functions.	Estradiol	99-108	estrogen receptor 2 (beta)	Mus musculus	68-95
26189884-6	2016	D-Asp induced phosphorylation of ERK and Akt proteins, stimulated expression of PCNA and Aurora B, and enhanced mRNA synthesis and protein expression of P450 aromatase and protein expression of Estrogen Receptor beta (ERbeta).	Aspartic Acid	2-5	estrogen receptor 2 (beta)	Mus musculus	218-224
25980457-0	2015	Contribution of estrogen receptor subtypes, ERalpha, ERbeta, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice.	Estradiol	80-89	estrogen receptor 2 (beta)	Mus musculus	53-59
25323043-6	2015	The inhibition of BMP4-induced BMP4 protein expression by oestrogen was prevented by the inhibitor of oestrogen receptor-beta, PHTPP, but not by the inhibitor of oestrogen receptor-alpha MPP.	PHTPP	127-132	estrogen receptor 2 (beta)	Mus musculus	102-125
25980457-6	2015	We confirmed that the ERalpha and ERbeta selective agonists (PPT and DPN) had effects on synaptic responses specific to animals that expressed the relevant receptor; however, PPT and DPN produced only a small increase in synaptic transmission relative to EB or the GPER1 agonist.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	61-64	estrogen receptor 2 (beta)	Mus musculus	34-40
26206299-8	2015	In contrast, 2,3-bis-4-hydroxyphenyl (DPN), a specific agonist for ERbeta, had no effect on neurite outgrowth.	NAD	38-41	estrogen receptor 2 (beta)	Mus musculus	67-73
25980457-6	2015	We confirmed that the ERalpha and ERbeta selective agonists (PPT and DPN) had effects on synaptic responses specific to animals that expressed the relevant receptor; however, PPT and DPN produced only a small increase in synaptic transmission relative to EB or the GPER1 agonist.	diarylpropionitrile	69-72	estrogen receptor 2 (beta)	Mus musculus	34-40
25980457-6	2015	We confirmed that the ERalpha and ERbeta selective agonists (PPT and DPN) had effects on synaptic responses specific to animals that expressed the relevant receptor; however, PPT and DPN produced only a small increase in synaptic transmission relative to EB or the GPER1 agonist.	diarylpropionitrile	183-186	estrogen receptor 2 (beta)	Mus musculus	34-40
26280130-1	2015	We recently reported that chronic 17beta-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERalpha), and independently of ERbeta.	Estradiol	34-50	estrogen receptor 2 (beta)	Mus musculus	262-268
25341395-15	2015	CONCLUSIONS: Soy and genistein at nutritional doses induce fat development in LFD-fed mice and adipogenesis in 3T3-L1 cells, with a mechanism that involves, at least in vitro, ERbeta and is dependent on cell differentiation stage.	Genistein	21-30	estrogen receptor 2 (beta)	Mus musculus	176-182
26491358-14	2015	In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group.	Tamoxifen	21-30	estrogen receptor 2 (beta)	Mus musculus	110-116
26491358-14	2015	In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group.	Tamoxifen	38-47	estrogen receptor 2 (beta)	Mus musculus	110-116
26491358-15	2015	mRNA expression of ERbeta, PI3K, and AKT was dramatically reduced by tamoxifen treatment in lung tissues compared with the estrogen group.	Tamoxifen	69-78	estrogen receptor 2 (beta)	Mus musculus	19-25
26208479-0	2015	Intracellular lactate-mediated induction of estrogen receptor beta (ERbeta) in biphasic malignant pleural mesothelioma cells.	Lactic Acid	14-21	estrogen receptor 2 (beta)	Mus musculus	44-66
26208479-0	2015	Intracellular lactate-mediated induction of estrogen receptor beta (ERbeta) in biphasic malignant pleural mesothelioma cells.	Lactic Acid	14-21	estrogen receptor 2 (beta)	Mus musculus	68-74
26208479-5	2015	We provide evidence that ERbeta expression is induced by increased intracellular lactate concentration.	Lactic Acid	81-88	estrogen receptor 2 (beta)	Mus musculus	25-31
26208479-6	2015	Spheroid culturing and tumor growth of ERbeta negative biphasic MPM in nude mice resulted in the induction of ERbeta expression and response to the selective agonist KB9520.	kb9520	166-172	estrogen receptor 2 (beta)	Mus musculus	39-45
26208479-6	2015	Spheroid culturing and tumor growth of ERbeta negative biphasic MPM in nude mice resulted in the induction of ERbeta expression and response to the selective agonist KB9520.	kb9520	166-172	estrogen receptor 2 (beta)	Mus musculus	110-116
25676031-8	2015	The small interfering RNAs (siRNAs) against the ERalpha (siERalpha) or ERbeta (siERbeta) was induced into N2A and SK-N-SH cells by transfection and resulted in a decrease in the level of corresponding ER transcript.	sierbeta	79-87	estrogen receptor 2 (beta)	Mus musculus	48-77
25341395-7	2015	E2 and genistein effects on ERalpha, ERbeta and PPARgamma transcriptional activities were characterized in ERalpha- or ERbeta-transfected 3T3L1 cells during differentiation, by the use of reporter plasmids.	Genistein	7-16	estrogen receptor 2 (beta)	Mus musculus	37-43
25341395-7	2015	E2 and genistein effects on ERalpha, ERbeta and PPARgamma transcriptional activities were characterized in ERalpha- or ERbeta-transfected 3T3L1 cells during differentiation, by the use of reporter plasmids.	Genistein	7-16	estrogen receptor 2 (beta)	Mus musculus	119-125
25893642-8	2015	Pretreatment with either ER-alpha or ER-beta agonist was, however, effective in blocking amphetamine-induced PPI disruption.	Amphetamine	89-100	estrogen receptor 2 (beta)	Mus musculus	37-44
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	Dihydrotestosterone	30-33	estrogen receptor 2 (beta)	Mus musculus	126-148
26166370-5	2015	In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor alpha (ERalpha) but not via estrogen receptor beta or androgen receptors.	Dehydroepiandrosterone	71-75	estrogen receptor 2 (beta)	Mus musculus	216-238
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	Dihydrotestosterone	30-33	estrogen receptor 2 (beta)	Mus musculus	150-156
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	5alpha-androstane-3beta	65-88	estrogen receptor 2 (beta)	Mus musculus	126-148
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	5alpha-androstane-3beta	65-88	estrogen receptor 2 (beta)	Mus musculus	150-156
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	17beta-diol	90-101	estrogen receptor 2 (beta)	Mus musculus	126-148
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	17beta-diol	90-101	estrogen receptor 2 (beta)	Mus musculus	150-156
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	Androstane-3,17-diol	103-113	estrogen receptor 2 (beta)	Mus musculus	126-148
25849728-2	2015	These estrogenic functions of DHT are mediated by its metabolite 5alpha-androstane-3beta, 17beta-diol (3beta-diol) binding to estrogen receptor beta (ERbeta).	Androstane-3,17-diol	103-113	estrogen receptor 2 (beta)	Mus musculus	150-156
25112706-9	2015	Western blot analysis further indicated that BPA at 0.4, 4, or 40 mg kg(-1)d(-1) significantly down-regulated the protein level of estrogen receptor beta (ERbeta) in the hippocampus of the adult males but not females, and inhibited the protein level of GABA(A)alpha2 receptor in hippocampus of males but promoted that of females.	bisphenol A	45-48	estrogen receptor 2 (beta)	Mus musculus	131-153
25837835-9	2015	Taken together, these results suggest that the CUMS-induced increase in the ratio of ERalpha/ERbeta causes dendritic remodeling, which in turn might be responsible for increase in anxiety- and depression-like behaviour in young male mice.	cums	47-51	estrogen receptor 2 (beta)	Mus musculus	93-99
25880554-9	2015	Use of specific estrogen receptor (ER)alpha- and ERbeta-agonists indicated involvement of both estrogen receptors (ER) in rapamycin effects on mTORC1 and mTORC2.	Sirolimus	122-131	estrogen receptor 2 (beta)	Mus musculus	49-55
25737208-6	2015	Meanwhile, ESR2, a tumor suppressor which is exclusively expressed in GCs, was suppressed in NGF-induced GC proliferation, and this effect was abrogated by U0126.	U 0126	156-161	estrogen receptor 2 (beta)	Mus musculus	11-15
25112706-9	2015	Western blot analysis further indicated that BPA at 0.4, 4, or 40 mg kg(-1)d(-1) significantly down-regulated the protein level of estrogen receptor beta (ERbeta) in the hippocampus of the adult males but not females, and inhibited the protein level of GABA(A)alpha2 receptor in hippocampus of males but promoted that of females.	bisphenol A	45-48	estrogen receptor 2 (beta)	Mus musculus	155-161
25112706-9	2015	Western blot analysis further indicated that BPA at 0.4, 4, or 40 mg kg(-1)d(-1) significantly down-regulated the protein level of estrogen receptor beta (ERbeta) in the hippocampus of the adult males but not females, and inhibited the protein level of GABA(A)alpha2 receptor in hippocampus of males but promoted that of females.	gamma-Aminobutyric Acid	253-257	estrogen receptor 2 (beta)	Mus musculus	131-153
25112706-9	2015	Western blot analysis further indicated that BPA at 0.4, 4, or 40 mg kg(-1)d(-1) significantly down-regulated the protein level of estrogen receptor beta (ERbeta) in the hippocampus of the adult males but not females, and inhibited the protein level of GABA(A)alpha2 receptor in hippocampus of males but promoted that of females.	gamma-Aminobutyric Acid	253-257	estrogen receptor 2 (beta)	Mus musculus	155-161
24846829-9	2015	Raloxifene-induced changes in Erbeta mRNA expression level were in parallel with ERbeta immunofluorescent labeling.	Raloxifene Hydrochloride	0-10	estrogen receptor 2 (beta)	Mus musculus	30-36
24846829-9	2015	Raloxifene-induced changes in Erbeta mRNA expression level were in parallel with ERbeta immunofluorescent labeling.	Raloxifene Hydrochloride	0-10	estrogen receptor 2 (beta)	Mus musculus	81-87
25167991-13	2015	Bladders in mice treated with the estrogen receptor-beta antagonist R,R-THC were similar to those in testosterone plus 17beta-estradiol treated mice.	(R,R)-THC	68-75	estrogen receptor 2 (beta)	Mus musculus	34-56
24726465-12	2014	Thus, we tested if the infusion of intra-hippocampal TPBM and PHTPP, selective antagonists of ERalpha and ERbeta, respectively, would block the memory enhancement effect of E2.	PHTPP	62-67	estrogen receptor 2 (beta)	Mus musculus	106-112
25112706-11	2015	Changes in the levels of GABA(A)alpha2 receptor and ERbeta proteins of hippocampus might be associated with BPA-induced changes in these emotional behaviors.	bisphenol A	108-111	estrogen receptor 2 (beta)	Mus musculus	52-58
25453074-0	2014	Multiple functional therapeutic effects of the estrogen receptor beta agonist indazole-Cl in a mouse model of multiple sclerosis.	3-chloro-2-(4-hydroxyphenyl)-2H-indazol-5-ol	78-89	estrogen receptor 2 (beta)	Mus musculus	47-69
25398007-2	2014	We previously reported that masculinization of the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), which is larger and has more neurons in males than in females, involves aromatized testosterone that acts via estrogen receptor-alpha (ERalpha), but not estrogen receptor-beta (ERbeta).	Testosterone	204-216	estrogen receptor 2 (beta)	Mus musculus	274-296
25398007-2	2014	We previously reported that masculinization of the principal nucleus of the bed nucleus of the stria terminalis (BNSTp), which is larger and has more neurons in males than in females, involves aromatized testosterone that acts via estrogen receptor-alpha (ERalpha), but not estrogen receptor-beta (ERbeta).	Testosterone	204-216	estrogen receptor 2 (beta)	Mus musculus	298-304
24510074-2	2014	Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	113-135
24510074-2	2014	Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	137-143
24510074-2	2014	Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling.	Estradiol	270-279	estrogen receptor 2 (beta)	Mus musculus	113-135
24510074-2	2014	Estradiol induces gene transcription and rapid membrane signaling mediated by estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), and a recently characterized G-protein coupled estrogen receptor, each with distinct distributions and ability to influence estradiol-dependent signaling.	Estradiol	270-279	estrogen receptor 2 (beta)	Mus musculus	137-143
24510074-5	2014	This work indicates a regulatory role of ERbeta in transcription and cognition, which depends on estradiol levels and the function of ERalpha.	Estradiol	97-106	estrogen receptor 2 (beta)	Mus musculus	41-47
24510074-7	2014	Vector-mediated expression of estrogen receptors in the hippocampus provides an innovative research approach and suggests that memory depends on the relative expression of ERalpha and ERbeta interacting with estradiol levels.	Estradiol	208-217	estrogen receptor 2 (beta)	Mus musculus	184-190
25429088-6	2015	Diosgenin induced an immediate and transient plasma membrane translocation of ESR1 and ESR2 from the nucleus, which was inhibited by the antiestrogen ICI 182 780 and PP2, an inhibitor of SRC.	Diosgenin	0-9	estrogen receptor 2 (beta)	Mus musculus	87-91
25070950-1	2014	The actual level of circulating estrogen (17beta-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERalpha and ERbeta, act as nuclear transcriptional regulators of multiple target genes.	Estradiol	42-58	estrogen receptor 2 (beta)	Mus musculus	190-196
24932804-6	2014	Using chromatin immunoprecipitation, we examined whether Esr2 and Oxt gene expression might be mediated by recruitment of the histone acetyltransferase cAMP response element binding protein (CBP) to their promoter regions after maternal memory consolidation.	Cyclic AMP	152-156	estrogen receptor 2 (beta)	Mus musculus	57-61
25156241-8	2014	On the other hand, Nar stimulation activates, via ERbeta, the phosphorylation of p38/MAPK involved in reducing the reactive oxygen species formation in skeletal muscle cells.	Reactive Oxygen Species	115-138	estrogen receptor 2 (beta)	Mus musculus	50-56
25232488-5	2014	Conversely, 17beta-estradiol treatment increased it in SVHUC-control endogenously expressing ERbeta.	Estradiol	12-28	estrogen receptor 2 (beta)	Mus musculus	93-99
24792519-6	2014	Decreased VEGF and ER-alpha reactivities and increased ER-beta reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group.	Finasteride	95-106	estrogen receptor 2 (beta)	Mus musculus	55-62
24077289-6	2014	Knockdown of FOXO3a or ERbeta expression abolished the increase of PUMA in response to 3beta-Adiol in LNCaP and PC3 cells, suggesting that FOXO3a mediates the apoptotic effect of 3beta-Adiol-activated ERbeta.	Androstane-3,17-diol	87-98	estrogen receptor 2 (beta)	Mus musculus	23-29
24077289-6	2014	Knockdown of FOXO3a or ERbeta expression abolished the increase of PUMA in response to 3beta-Adiol in LNCaP and PC3 cells, suggesting that FOXO3a mediates the apoptotic effect of 3beta-Adiol-activated ERbeta.	Androstane-3,17-diol	179-190	estrogen receptor 2 (beta)	Mus musculus	23-29
24960160-3	2014	Here, we have shown that phosphorylation of a tyrosine residue (Y36) present in ERbeta, but not in ERalpha, dictates ERbeta-specific activation of transcription and is required for ERbeta-dependent inhibition of cancer cell growth in culture and in murine xenografts.	Tyrosine	46-54	estrogen receptor 2 (beta)	Mus musculus	80-86
24960160-3	2014	Here, we have shown that phosphorylation of a tyrosine residue (Y36) present in ERbeta, but not in ERalpha, dictates ERbeta-specific activation of transcription and is required for ERbeta-dependent inhibition of cancer cell growth in culture and in murine xenografts.	Tyrosine	46-54	estrogen receptor 2 (beta)	Mus musculus	117-123
25473491-8	2014	In conclusion, the effects of 8-PN on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption were mediated by ERalpha instead of ERbeta and the efficacy was more potent than that of the two classic phytoestrogens: genistein and daidzein.	8-prenylnaringenin	30-34	estrogen receptor 2 (beta)	Mus musculus	156-162
24796879-6	2014	Furthermore, in primary cultured astrocytes, we demonstrated that E2 up-regulated Ndrg2 mRNA and protein expression in a dose- and time-dependent manner and that the ERbeta agonist DPN but not the ERalpha agonist PPT up-regulated Ndrg2 expression.	NAD	181-184	estrogen receptor 2 (beta)	Mus musculus	166-172
24796879-8	2014	After the OVX mice received continuous subcutaneous injections of 50mug/kg E2, 100mug/kg E2 or the ERbeta agonist DPN for 10 days, the Ndrg2 expression significantly increased compared with that of the OVX mice.	NAD	114-117	estrogen receptor 2 (beta)	Mus musculus	99-105
24792519-6	2014	Decreased VEGF and ER-alpha reactivities and increased ER-beta reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group.	Semaxinib	108-114	estrogen receptor 2 (beta)	Mus musculus	55-62
24792519-6	2014	Decreased VEGF and ER-alpha reactivities and increased ER-beta reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group.	Semaxinib	140-146	estrogen receptor 2 (beta)	Mus musculus	55-62
24216299-5	2014	Besides, the treatment of Aroclor 1254 decreased the protein expression of estrogen receptor (ER)-alpha while increasing that of ERbeta.	Aroclors	26-33	estrogen receptor 2 (beta)	Mus musculus	129-135
24742230-6	2014	Western blot analysis results showed that estrogen receptor alpha (ER-alpha), estrogen receptor beta (ER-beta), beta-catenin and Bcl-2 protein expression increased after MC3T3-E1 cells were treated with dioscin.	dioscin	203-210	estrogen receptor 2 (beta)	Mus musculus	78-100
24742230-6	2014	Western blot analysis results showed that estrogen receptor alpha (ER-alpha), estrogen receptor beta (ER-beta), beta-catenin and Bcl-2 protein expression increased after MC3T3-E1 cells were treated with dioscin.	dioscin	203-210	estrogen receptor 2 (beta)	Mus musculus	102-109
24654233-13	2014	The greater increase in physiological MH in females is mediated by induction of AKT signalling, MAPK pathways, protein synthesis, and mitochondrial adaptation via ERbeta.	mh	38-40	estrogen receptor 2 (beta)	Mus musculus	163-169
24216299-6	2014	Then the administration of selective ERalpha agonist PPT partly reversed Aroclor 1254-induced alteration in Bcl-2, caspase-3 and cyclin D1 protein expression while selective ERbeta agonist DPN accelerated it.	NAD	189-192	estrogen receptor 2 (beta)	Mus musculus	174-180
24216299-7	2014	These results suggest that Aroclor 1254, working through ERalpha and ERbeta, interferes with the expression of proteins involved in the balance between cellular apoptosis and proliferation.	Aroclors	27-34	estrogen receptor 2 (beta)	Mus musculus	69-75
24498408-1	2014	The female steroid, 17beta-estradiol (E2), is important for pancreatic beta-cell function and acts via at least three estrogen receptors (ER), ERalpha, ERbeta, and the G-protein coupled ER (GPER).	Steroids	11-18	estrogen receptor 2 (beta)	Mus musculus	152-158
24148819-2	2014	Using in vitro cell lines and an in vivo carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced mouse BCa model, we found that ERbeta plays a positive role in promoting BCa progression.	Butylhydroxybutylnitrosamine	52-90	estrogen receptor 2 (beta)	Mus musculus	136-142
24148819-2	2014	Using in vitro cell lines and an in vivo carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced mouse BCa model, we found that ERbeta plays a positive role in promoting BCa progression.	Butylhydroxybutylnitrosamine	92-95	estrogen receptor 2 (beta)	Mus musculus	136-142
24498408-1	2014	The female steroid, 17beta-estradiol (E2), is important for pancreatic beta-cell function and acts via at least three estrogen receptors (ER), ERalpha, ERbeta, and the G-protein coupled ER (GPER).	Estradiol	20-36	estrogen receptor 2 (beta)	Mus musculus	152-158
24341716-5	2013	Before performing the behavioral task the mice were given saline or PHTPP (an estrogen receptor beta [ER-beta] antagonist) via bilateral infusion into the main olfactory bulb.	PHTPP	68-73	estrogen receptor 2 (beta)	Mus musculus	78-100
24361291-10	2014	In addition, using estrogen receptor beta (ERbeta) knockout mouse myoblasts, it was demonstrated that the effects of stilbene compounds on cell growth and stress resistance all require ERbeta.	Stilbenes	117-125	estrogen receptor 2 (beta)	Mus musculus	19-41
24361291-10	2014	In addition, using estrogen receptor beta (ERbeta) knockout mouse myoblasts, it was demonstrated that the effects of stilbene compounds on cell growth and stress resistance all require ERbeta.	Stilbenes	117-125	estrogen receptor 2 (beta)	Mus musculus	43-49
24361291-10	2014	In addition, using estrogen receptor beta (ERbeta) knockout mouse myoblasts, it was demonstrated that the effects of stilbene compounds on cell growth and stress resistance all require ERbeta.	Stilbenes	117-125	estrogen receptor 2 (beta)	Mus musculus	185-191
24184124-4	2014	3beta-Adiol is unable to bind androgen receptor (AR), but exerts its protection against PC by specifically interacting with estrogen receptor beta (ERbeta).	Androstane-3,17-diol	0-11	estrogen receptor 2 (beta)	Mus musculus	124-146
24184124-4	2014	3beta-Adiol is unable to bind androgen receptor (AR), but exerts its protection against PC by specifically interacting with estrogen receptor beta (ERbeta).	Androstane-3,17-diol	0-11	estrogen receptor 2 (beta)	Mus musculus	148-154
24341716-5	2013	Before performing the behavioral task the mice were given saline or PHTPP (an estrogen receptor beta [ER-beta] antagonist) via bilateral infusion into the main olfactory bulb.	PHTPP	68-73	estrogen receptor 2 (beta)	Mus musculus	102-109
24341716-10	2013	After habituation, gonadectomized 17beta-estradiol-treated mice retained memory of an odor for 30 min, whereas non-estradiol-treated, 17beta-estradiol+ERbeta antagonist (PHTPP), and untreated male mice did not remember an odor 30 min after habituation.	PHTPP	170-175	estrogen receptor 2 (beta)	Mus musculus	151-157
23376369-4	2013	Transient focal ischemic stroke was induced in ovariectomized female C57BL/6 mice (age 10-11weeks) that were treated with the ERbeta-selective agonist diarylpropionitrile (DPN).	diarylpropionitrile	151-170	estrogen receptor 2 (beta)	Mus musculus	126-132
24191028-3	2013	ERbeta is the target molecule of DPN because DPN treatment fails to decrease EAE clinical symptoms in global ERbeta-null mice.	diarylpropionitrile	33-36	estrogen receptor 2 (beta)	Mus musculus	0-6
24191028-3	2013	ERbeta is the target molecule of DPN because DPN treatment fails to decrease EAE clinical symptoms in global ERbeta-null mice.	diarylpropionitrile	45-48	estrogen receptor 2 (beta)	Mus musculus	0-6
24191028-5	2013	To this end, we selectively deleted ERbeta in OLs using the well-characterized Cre-loxP system for conditional gene knockout (CKO) in mice.	N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine	46-49	estrogen receptor 2 (beta)	Mus musculus	36-42
24191028-7	2013	ERbeta CKO in OLs prevented DPN-induced decrease in EAE clinical disease.	N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine	14-17	estrogen receptor 2 (beta)	Mus musculus	0-6
24191028-7	2013	ERbeta CKO in OLs prevented DPN-induced decrease in EAE clinical disease.	diarylpropionitrile	28-31	estrogen receptor 2 (beta)	Mus musculus	0-6
24191028-8	2013	DPN treatment during EAE did not attenuate demyelination, only partially improved axon conduction, and did not activate the phosphatidylinositol 3-kinase/serine-threonine-specific protein kinase/mammalian target of rapamycin signaling pathway in ERbeta CKO mice.	diarylpropionitrile	0-3	estrogen receptor 2 (beta)	Mus musculus	246-252
24191028-9	2013	However, DPN treatment significantly increased brain-derived neurotrophic factor levels in ERbeta CKO mice.	diarylpropionitrile	9-12	estrogen receptor 2 (beta)	Mus musculus	91-97
24191028-10	2013	These findings demonstrate that signaling through ERbeta in OLs is essential for the beneficial myelination effects of the ERbeta ligand DPN in chronic EAE mice.	N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine	60-63	estrogen receptor 2 (beta)	Mus musculus	50-56
24191028-10	2013	These findings demonstrate that signaling through ERbeta in OLs is essential for the beneficial myelination effects of the ERbeta ligand DPN in chronic EAE mice.	N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine	60-63	estrogen receptor 2 (beta)	Mus musculus	123-129
24191028-10	2013	These findings demonstrate that signaling through ERbeta in OLs is essential for the beneficial myelination effects of the ERbeta ligand DPN in chronic EAE mice.	diarylpropionitrile	137-140	estrogen receptor 2 (beta)	Mus musculus	50-56
24191028-10	2013	These findings demonstrate that signaling through ERbeta in OLs is essential for the beneficial myelination effects of the ERbeta ligand DPN in chronic EAE mice.	diarylpropionitrile	137-140	estrogen receptor 2 (beta)	Mus musculus	123-129
23471663-0	2013	Raloxifene upregulated mesangial cell MMP-2 activity via ER-beta through transcriptional regulation.	Raloxifene Hydrochloride	0-10	estrogen receptor 2 (beta)	Mus musculus	57-64
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	75-85	estrogen receptor 2 (beta)	Mus musculus	20-42
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	75-85	estrogen receptor 2 (beta)	Mus musculus	44-51
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	75-85	estrogen receptor 2 (beta)	Mus musculus	182-189
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	137-147	estrogen receptor 2 (beta)	Mus musculus	20-42
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	137-147	estrogen receptor 2 (beta)	Mus musculus	44-51
23471663-4	2013	An antibody against estrogen receptor-beta (ER-beta) blocked the effect of raloxifene on MMP-2 expression, suggesting that the effect of raloxifene on MMP-2 activity was mediated by ER-beta.	Raloxifene Hydrochloride	137-147	estrogen receptor 2 (beta)	Mus musculus	182-189
23471663-8	2013	In addition, we also found that the effect of raloxifene on MMP-2 expression was mediated via its binding to ER-beta.	Raloxifene Hydrochloride	46-56	estrogen receptor 2 (beta)	Mus musculus	109-116
23557759-1	2013	OBJECTIVE: To investigate the effect of the estrogen receptor-beta (ERbeta) agonist diarylpropionitrile (DPN) on lipopolysaccharide (LPS)-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages and the possible mechanisms.	diarylpropionitrile	84-103	estrogen receptor 2 (beta)	Mus musculus	44-66
23557759-1	2013	OBJECTIVE: To investigate the effect of the estrogen receptor-beta (ERbeta) agonist diarylpropionitrile (DPN) on lipopolysaccharide (LPS)-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages and the possible mechanisms.	diarylpropionitrile	84-103	estrogen receptor 2 (beta)	Mus musculus	68-74
23557759-1	2013	OBJECTIVE: To investigate the effect of the estrogen receptor-beta (ERbeta) agonist diarylpropionitrile (DPN) on lipopolysaccharide (LPS)-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages and the possible mechanisms.	diarylpropionitrile	105-108	estrogen receptor 2 (beta)	Mus musculus	44-66
23557759-1	2013	OBJECTIVE: To investigate the effect of the estrogen receptor-beta (ERbeta) agonist diarylpropionitrile (DPN) on lipopolysaccharide (LPS)-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages and the possible mechanisms.	diarylpropionitrile	105-108	estrogen receptor 2 (beta)	Mus musculus	68-74
23557759-8	2013	Small interfering RNA targeting the ERbeta gene inhibited the effect of DPN on RANTES production.	diarylpropionitrile	72-75	estrogen receptor 2 (beta)	Mus musculus	36-42
23557759-10	2013	CONCLUSION(S): Diarylpropionitrile down-regulates LPS-induced RANTES production via ERbeta.	diarylpropionitrile	15-34	estrogen receptor 2 (beta)	Mus musculus	84-90
23716699-4	2013	Here, we provide evidence that maternal exposure during pregnancy to environmentally relevant doses of BPA (2, 20, and 200 microg/kg/d) in mice induces sex-specific, dose-dependent (linear and curvilinear), and brain region-specific changes in expression of genes encoding estrogen receptors (ERs; ERalpha and ERbeta) and estrogen-related receptor-gamma in juvenile offspring.	bisphenol A	103-106	estrogen receptor 2 (beta)	Mus musculus	310-353
23730403-3	2013	Estrogen receptors (ERs), primarily ERbeta, are expressed in normal urothelium and urothelial carcinoma, and blocking ER function with selective ER modulators such as tamoxifen inhibits bladder cancer cell proliferation in vitro.	Tamoxifen	167-176	estrogen receptor 2 (beta)	Mus musculus	36-42
23730403-8	2013	ERbeta was present in all mice and thus is a potential mediator of the tamoxifen chemoprotective effect.	Tamoxifen	71-80	estrogen receptor 2 (beta)	Mus musculus	0-6
23447562-0	2013	The role of estrogen receptor beta in transplacental cancer prevention by indole-3-carbinol.	indole-3-carbinol	74-91	estrogen receptor 2 (beta)	Mus musculus	12-34
23447562-1	2013	In the present study, the efficacy of indole-3-carbinol (I3C), a key bioactive component of cruciferous vegetables, for prevention of cancer in offspring exposed in utero to the environmental carcinogen dibenzo[def,p]chrysene (DBC) was evaluated using an estrogen receptor beta (ERbeta) knockout mouse model.	indole-3-carbinol	38-55	estrogen receptor 2 (beta)	Mus musculus	255-277
23447562-1	2013	In the present study, the efficacy of indole-3-carbinol (I3C), a key bioactive component of cruciferous vegetables, for prevention of cancer in offspring exposed in utero to the environmental carcinogen dibenzo[def,p]chrysene (DBC) was evaluated using an estrogen receptor beta (ERbeta) knockout mouse model.	indole-3-carbinol	38-55	estrogen receptor 2 (beta)	Mus musculus	279-285
24076016-0	2013	Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor beta.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	79-101
24076016-6	2013	We found that estradiol-induced downregulation of synaptopodin is mediated by estrogen receptor beta.	Estradiol	14-23	estrogen receptor 2 (beta)	Mus musculus	78-100
24076016-7	2013	Estrogen receptor beta in turn, is upregulated in response to intracellular estradiol ablation following inhibition of estradiol synthesis by letrozole in dissociated hippocampal cultures, as well as in the hippocampus of the aromatase knock-out mouse.	Estradiol	76-85	estrogen receptor 2 (beta)	Mus musculus	0-22
24076016-7	2013	Estrogen receptor beta in turn, is upregulated in response to intracellular estradiol ablation following inhibition of estradiol synthesis by letrozole in dissociated hippocampal cultures, as well as in the hippocampus of the aromatase knock-out mouse.	Estradiol	119-128	estrogen receptor 2 (beta)	Mus musculus	0-22
24076016-7	2013	Estrogen receptor beta in turn, is upregulated in response to intracellular estradiol ablation following inhibition of estradiol synthesis by letrozole in dissociated hippocampal cultures, as well as in the hippocampus of the aromatase knock-out mouse.	Letrozole	142-151	estrogen receptor 2 (beta)	Mus musculus	0-22
24076016-8	2013	Thus, it appears that both the application of estradiol, via binding to estrogen receptor beta, and letrozole, via upregulation of estrogen receptor beta, eventually result in a downregulation of synaptopodin.	Estradiol	46-55	estrogen receptor 2 (beta)	Mus musculus	72-94
24076016-8	2013	Thus, it appears that both the application of estradiol, via binding to estrogen receptor beta, and letrozole, via upregulation of estrogen receptor beta, eventually result in a downregulation of synaptopodin.	Estradiol	46-55	estrogen receptor 2 (beta)	Mus musculus	131-153
24076016-8	2013	Thus, it appears that both the application of estradiol, via binding to estrogen receptor beta, and letrozole, via upregulation of estrogen receptor beta, eventually result in a downregulation of synaptopodin.	Letrozole	100-109	estrogen receptor 2 (beta)	Mus musculus	131-153
24048848-5	2013	Dorsal hippocampal (DH) infusion of ERalpha (PPT) or ERbeta (DPN) agonists enhanced novel object recognition and object placement memory in ovariectomized female mice in an ERK-dependent manner, suggesting that these receptors influence memory by rapidly activating hippocampal cell signaling.	NAD	61-64	estrogen receptor 2 (beta)	Mus musculus	53-59
24252174-4	2013	Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the current study determined whether changes in NRG1 isoforms and erbin may be associated with altered Erb B2 signaling in DPN.	dpn	230-233	estrogen receptor 2 (beta)	Mus musculus	210-213
24252174-5	2013	RESULTS: Swiss Webster mice were rendered diabetic with streptozotocin (STZ) and after 12 weeks of diabetes, treated with erlotinib, an inhibitor of Erb B2 activation.	Erlotinib Hydrochloride	122-131	estrogen receptor 2 (beta)	Mus musculus	149-152
24252174-6	2013	Inhibition of Erb B2 signaling partially reversed several pathophysiologic aspects of DPN including a pronounced sensory hypoalgesia, nerve conduction velocity deficits and the decrease in epidermal nerve fiber innervation.	dpn	86-89	estrogen receptor 2 (beta)	Mus musculus	14-17
24252174-11	2013	Together, imbalanced NRG1 isoforms and downregulated erbin may contribute to the dysregulation of Erb B2 signaling in the development of DPN.	dpn	137-140	estrogen receptor 2 (beta)	Mus musculus	98-101
22907432-0	2013	Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer.	Tamoxifen	0-9	estrogen receptor 2 (beta)	Mus musculus	52-74
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Tamoxifen	0-3	estrogen receptor 2 (beta)	Mus musculus	26-48
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Tamoxifen	0-3	estrogen receptor 2 (beta)	Mus musculus	50-56
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Reactive Oxygen Species	104-127	estrogen receptor 2 (beta)	Mus musculus	26-48
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Reactive Oxygen Species	104-127	estrogen receptor 2 (beta)	Mus musculus	50-56
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Reactive Oxygen Species	129-132	estrogen receptor 2 (beta)	Mus musculus	26-48
22907432-2	2013	TAM engaged mitochondrial estrogen receptor beta (ERbeta) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity.	Reactive Oxygen Species	129-132	estrogen receptor 2 (beta)	Mus musculus	50-56
22907432-7	2013	Tumor MnSOD and mitochondrial ERbeta are therefore targets for therapeutic intervention to reverse TAM resistance and enhance a cell death response.	Tamoxifen	99-102	estrogen receptor 2 (beta)	Mus musculus	30-36
23653160-9	2013	Abnormalities observed in Arom+ and neonatally DES-treated mice correlate with the expression of estrogen receptor-beta (ERbeta) in the affected structures.	Diethylstilbestrol	47-50	estrogen receptor 2 (beta)	Mus musculus	97-119
23653160-9	2013	Abnormalities observed in Arom+ and neonatally DES-treated mice correlate with the expression of estrogen receptor-beta (ERbeta) in the affected structures.	Diethylstilbestrol	47-50	estrogen receptor 2 (beta)	Mus musculus	121-127
23557759-0	2013	Estrogen receptor beta agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor kappaB activation.	diarylpropionitrile	31-50	estrogen receptor 2 (beta)	Mus musculus	0-22
23731360-3	2013	(Z)-Norendoxifen displayed affinity for aromatase (Ki 442 nM), estrogen receptor-alpha (EC50 17 nM), and estrogen receptor-beta (EC50 27.5 nM), while the corresponding values for (E)-norendoxifen were aromatase (Ki 48 nM), estrogen receptor-alpha (EC50 58.7 nM), and estrogen receptor-beta (EC50 78.5 nM).	N,N-didesmethyl-4-hydroxytamoxifen	4-16	estrogen receptor 2 (beta)	Mus musculus	105-127
23731360-3	2013	(Z)-Norendoxifen displayed affinity for aromatase (Ki 442 nM), estrogen receptor-alpha (EC50 17 nM), and estrogen receptor-beta (EC50 27.5 nM), while the corresponding values for (E)-norendoxifen were aromatase (Ki 48 nM), estrogen receptor-alpha (EC50 58.7 nM), and estrogen receptor-beta (EC50 78.5 nM).	N,N-didesmethyl-4-hydroxytamoxifen	4-16	estrogen receptor 2 (beta)	Mus musculus	267-289
23349481-2	2013	We evaluated the role and antidiabetic actions of the ERbeta selective agonist WAY200070 as an insulinotropic molecule.	WAY 200070	79-88	estrogen receptor 2 (beta)	Mus musculus	54-60
22665260-7	2013	These neuronal changes were prevented in mice 1-3 weeks (but not 10 weeks) after OVX by the selective ERbeta agonist, LY3201, given as continuous release pellets for 3 days.	LY3201	118-124	estrogen receptor 2 (beta)	Mus musculus	102-108
22751110-5	2013	In vivo, ERbeta agonists induced mammary gland hyperplasia and MC4-L2 tumour growth to a similar extent as the ERalpha agonist 4,4",4""-(4-propyl-(1H)-pyrazole-1,3,5-triyl) trisphenol (PPT) or 17beta-estradiol (E2) and correlated with higher number of mitotic and lower number of apoptotic features.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	185-188	estrogen receptor 2 (beta)	Mus musculus	9-15
22751110-5	2013	In vivo, ERbeta agonists induced mammary gland hyperplasia and MC4-L2 tumour growth to a similar extent as the ERalpha agonist 4,4",4""-(4-propyl-(1H)-pyrazole-1,3,5-triyl) trisphenol (PPT) or 17beta-estradiol (E2) and correlated with higher number of mitotic and lower number of apoptotic features.	Estradiol	193-209	estrogen receptor 2 (beta)	Mus musculus	9-15
22751110-9	2013	Inhibition of MEK 1/2 with UO126 completely restored ERbeta growth-inhibitory effects, whereas inhibition of PI3K by LY294002 inhibited ERbeta-induced proliferation.	U 0126	27-32	estrogen receptor 2 (beta)	Mus musculus	53-59
22751110-9	2013	Inhibition of MEK 1/2 with UO126 completely restored ERbeta growth-inhibitory effects, whereas inhibition of PI3K by LY294002 inhibited ERbeta-induced proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	estrogen receptor 2 (beta)	Mus musculus	136-142
22753646-9	2012	In conclusion, genistein is able to inhibit WDC in the presence of both ERs, but the effect of estrogen signaling on PDC is dominant over any dietary treatment, suggesting that improved differential targeting of ERalpha vs. ERbeta would result in prevention of advanced prostate cancer.	Genistein	15-24	estrogen receptor 2 (beta)	Mus musculus	224-230
23332367-8	2013	Interestingly, the estrogen receptors ERa and ERb were several times more abundant in dystrophic than in normal muscles, and tamoxifen normalized the relative abundance of ERb isoforms.	Tamoxifen	125-134	estrogen receptor 2 (beta)	Mus musculus	172-175
22488198-8	2012	These results demonstrate for the first time that ERbeta provides protection in the AOM/DSS-induced CAC model in mice, suggesting a preventive and/or therapeutic potential for the use of ERbeta-selective agonists in IBD.	dss	88-91	estrogen receptor 2 (beta)	Mus musculus	50-56
22672467-4	2012	In MPTP-lesioned mice, oestrogen receptor (ER)alpha and ERbeta are important in 17beta-oestradiol-induced neuroprotection.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-7	estrogen receptor 2 (beta)	Mus musculus	56-62
22672467-4	2012	In MPTP-lesioned mice, oestrogen receptor (ER)alpha and ERbeta are important in 17beta-oestradiol-induced neuroprotection.	Estradiol	80-97	estrogen receptor 2 (beta)	Mus musculus	56-62
22796107-1	2012	Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body.	Estradiol	145-154	estrogen receptor 2 (beta)	Mus musculus	102-124
22796107-1	2012	Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body.	Estradiol	145-154	estrogen receptor 2 (beta)	Mus musculus	126-132
22796107-5	2012	In recent years several ERbeta-specific compounds (selective estrogen receptor beta modulators; SERM-beta) have become available, and research suggests potential utility of these compounds in menopausal symptom relief, breast cancer prevention, diseases that have an inflammatory component, osteoporosis, cardiovascular disease, and inflammatory bowel disease, as well as modulation of mood, and anxiety.	serm-beta	96-105	estrogen receptor 2 (beta)	Mus musculus	24-30
22749433-3	2012	METHODS: We have prepared the fluorine-18 labeled form of 8beta-(2-fluoroethyl)estradiol (8BFEE(2)), an analog of an ERbeta-selective steroidal estrogen, 8beta-vinylestradiol; efficient incorporation of fluorine-18 was achieved, but required very vigorous conditions.	Fluorine-18	30-41	estrogen receptor 2 (beta)	Mus musculus	117-123
22700872-2	2012	Our present study provides evidence that the ERbeta agonist, 2,3-bis-(4-hydroxy-phenyl)-propionitrile (DPN), and the selective estrogen receptor modulator tamoxifen (Tam), inhibit estrogen-induced DNA damage and mammary tumorigenesis in the aromatase transgenic (Arom) mouse model.	NAD	103-106	estrogen receptor 2 (beta)	Mus musculus	45-51
22700872-2	2012	Our present study provides evidence that the ERbeta agonist, 2,3-bis-(4-hydroxy-phenyl)-propionitrile (DPN), and the selective estrogen receptor modulator tamoxifen (Tam), inhibit estrogen-induced DNA damage and mammary tumorigenesis in the aromatase transgenic (Arom) mouse model.	Tamoxifen	166-169	estrogen receptor 2 (beta)	Mus musculus	45-51
23339165-8	2013	Because rapamycin downregulated ERbeta in female mice, we next studied ERbeta(-/-) normotensive DOCA-salt females.	Sirolimus	8-17	estrogen receptor 2 (beta)	Mus musculus	32-38
23339165-11	2013	ERbeta(-/-) DOCA-salt females showed similar mTORC1 and mTORC2 response patterns.	Desoxycorticosterone Acetate	12-16	estrogen receptor 2 (beta)	Mus musculus	0-6
23339165-11	2013	ERbeta(-/-) DOCA-salt females showed similar mTORC1 and mTORC2 response patterns.	Salts	17-21	estrogen receptor 2 (beta)	Mus musculus	0-6
23401502-6	2013	Treatment of EAE mice with LY3201, a selective ERbeta agonist provided by Eli Lilly, resulted in marked reduction of activated microglia in the spinal cord.	LY3201	27-33	estrogen receptor 2 (beta)	Mus musculus	47-53
22892812-4	2012	The selective ERalpha agonist 16alpha-LE2 and the nonselective ERalpha and ERbeta agonist 17beta-estradiol completely restored cardiac glucose uptake in ovariectomized mice.	Estradiol	90-106	estrogen receptor 2 (beta)	Mus musculus	75-81
22892812-4	2012	The selective ERalpha agonist 16alpha-LE2 and the nonselective ERalpha and ERbeta agonist 17beta-estradiol completely restored cardiac glucose uptake in ovariectomized mice.	Glucose	135-142	estrogen receptor 2 (beta)	Mus musculus	75-81
22398780-12	2012	CONCLUSION: These findings demonstrated that combined administration of Ad-ERbeta with raloxifene represents a promising colon cancer therapeutic strategy.	Raloxifene Hydrochloride	87-97	estrogen receptor 2 (beta)	Mus musculus	75-81
23026669-5	2012	These actions are mediated by the activation of ER alpha (ERalpha) and beta (ERbeta), which regulate target gene transcription (genomic action) through two independent activation functions AF-1 and AF-2, but can also elicit rapid membrane initiated steroid signals.	Steroids	249-256	estrogen receptor 2 (beta)	Mus musculus	77-83
22371119-1	2012	Estrogen receptors (ERalpha and ERbeta) mediate the neuroprotection of estrogens against MPTP-induced striatal dopamine (DA) depletion.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	89-93	estrogen receptor 2 (beta)	Mus musculus	32-38
22371119-1	2012	Estrogen receptors (ERalpha and ERbeta) mediate the neuroprotection of estrogens against MPTP-induced striatal dopamine (DA) depletion.	Dopamine	111-119	estrogen receptor 2 (beta)	Mus musculus	32-38
22371119-7	2012	The MPTP-induced up-regulation of Nav1.1 and Nav1.9, down-regulation of Nav1.6 in DRG neurons may be through ERbeta, up-regulation of Nav1.7 and down-regulation of Nav1.8 are dependent on both ERalpha and ERbeta.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-8	estrogen receptor 2 (beta)	Mus musculus	109-115
22371119-7	2012	The MPTP-induced up-regulation of Nav1.1 and Nav1.9, down-regulation of Nav1.6 in DRG neurons may be through ERbeta, up-regulation of Nav1.7 and down-regulation of Nav1.8 are dependent on both ERalpha and ERbeta.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-8	estrogen receptor 2 (beta)	Mus musculus	205-211
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	androstane	18-35	estrogen receptor 2 (beta)	Mus musculus	4-10
22434086-11	2012	Taken together, the data suggest that in the presence of 3beta-diol, ERbeta associates with cAMP response element-binding protein and steroid receptor coactivator-1 to form a functional complex that drives Oxt gene expression.	3beta-diol	57-67	estrogen receptor 2 (beta)	Mus musculus	69-75
22434086-11	2012	Taken together, the data suggest that in the presence of 3beta-diol, ERbeta associates with cAMP response element-binding protein and steroid receptor coactivator-1 to form a functional complex that drives Oxt gene expression.	Cyclic AMP	92-96	estrogen receptor 2 (beta)	Mus musculus	69-75
22358497-8	2012	These results indicate that ERbeta regulates the expression of NHE3 in the proximal colon of pregnant mice through estrogen action, suggesting the involvement of increased sodium absorption by up-regulated NHE3 in constipation during pregnancy.	Sodium	172-178	estrogen receptor 2 (beta)	Mus musculus	28-34
22175770-0	2012	Interaction between P2X3 and oestrogen receptor (ER)alpha/ERbeta in ATP-mediated calcium signalling in mice sensory neurones.	Adenosine Triphosphate	68-71	estrogen receptor 2 (beta)	Mus musculus	58-64
22175770-0	2012	Interaction between P2X3 and oestrogen receptor (ER)alpha/ERbeta in ATP-mediated calcium signalling in mice sensory neurones.	Calcium	81-88	estrogen receptor 2 (beta)	Mus musculus	58-64
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	3beta	37-42	estrogen receptor 2 (beta)	Mus musculus	4-10
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	17beta-diol	43-54	estrogen receptor 2 (beta)	Mus musculus	4-10
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	3beta-diol	56-66	estrogen receptor 2 (beta)	Mus musculus	4-10
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	Dihydrotestosterone	219-238	estrogen receptor 2 (beta)	Mus musculus	170-192
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	Dihydrotestosterone	219-238	estrogen receptor 2 (beta)	Mus musculus	194-200
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	3beta	250-255	estrogen receptor 2 (beta)	Mus musculus	170-192
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	3beta	250-255	estrogen receptor 2 (beta)	Mus musculus	194-200
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	17beta-diol	256-267	estrogen receptor 2 (beta)	Mus musculus	170-192
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	17beta-diol	256-267	estrogen receptor 2 (beta)	Mus musculus	194-200
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	3beta-diol	269-279	estrogen receptor 2 (beta)	Mus musculus	170-192
22434086-4	2012	Within the paraventricular nucleus of the hypothalamus, oxytocinergic neurons involved in regulating the stress response do not express androgen receptors but do express estrogen receptor-beta (ERbeta), which binds the dihydrotestosterone metabolite 3beta,17beta-diol (3beta-diol).	3beta-diol	269-279	estrogen receptor 2 (beta)	Mus musculus	194-200
22434086-5	2012	Testosterone regulation of the HPA axis thus appears to involve the conversion to the ERbeta-selective ligand 5alpha-androstane, 3beta-diol.	Testosterone	0-12	estrogen receptor 2 (beta)	Mus musculus	86-92
22434086-5	2012	Testosterone regulation of the HPA axis thus appears to involve the conversion to the ERbeta-selective ligand 5alpha-androstane, 3beta-diol.	androstane	110-127	estrogen receptor 2 (beta)	Mus musculus	86-92
22434086-5	2012	Testosterone regulation of the HPA axis thus appears to involve the conversion to the ERbeta-selective ligand 5alpha-androstane, 3beta-diol.	3beta-diol	129-139	estrogen receptor 2 (beta)	Mus musculus	86-92
22209345-7	2012	Estradiol, and the specific estrogen receptor-beta agonist DPN, decreased current amplitude measured in the morning (AM), but had no effect on afternoon currents.	NAD	59-62	estrogen receptor 2 (beta)	Mus musculus	28-50
22406418-8	2012	In contrast, the ERbeta selective agonist DPN (100 pM) significantly reduced the Ca(2+)-influx (32%).	NAD	42-45	estrogen receptor 2 (beta)	Mus musculus	17-23
22169964-0	2012	17beta-Estradiol regulates the gene expression of voltage-gated sodium channels: role of estrogen receptor alpha and estrogen receptor beta.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	117-139
22275727-11	2012	CONCLUSIONS: These data suggest that DES-induced SV toxicity and feminization are primarily mediated by ERalpha; however, some aspects of androgen response may require the action of ERbeta.	Diethylstilbestrol	37-40	estrogen receptor 2 (beta)	Mus musculus	182-188
22209345-10	2012	The ER-beta agonist DPN did not mimic the effect of estradiol on DAPs, and the modulation of DAPs by estradiol was no longer present in cells from postreproductive animals.	NAD	20-23	estrogen receptor 2 (beta)	Mus musculus	4-11
22186418-2	2012	Using a combination of pharmacological and genetic approaches, we confirmed that the anxiolytic actions of estradiol are mediated by ERbeta and extended and these observations to demonstrate the neuroanatomical targets involved in ERbeta activation in these behavioral responses.	Estradiol	107-116	estrogen receptor 2 (beta)	Mus musculus	133-139
22186418-2	2012	Using a combination of pharmacological and genetic approaches, we confirmed that the anxiolytic actions of estradiol are mediated by ERbeta and extended and these observations to demonstrate the neuroanatomical targets involved in ERbeta activation in these behavioral responses.	Estradiol	107-116	estrogen receptor 2 (beta)	Mus musculus	231-237
22100717-3	2012	Our laboratory has demonstrated that estradiol (E2) inhibits the development of pre-neoplastic lesions through an estrogen receptor beta (ERbeta) mediated mechanism in mice.	Estradiol	37-46	estrogen receptor 2 (beta)	Mus musculus	114-136
22100717-3	2012	Our laboratory has demonstrated that estradiol (E2) inhibits the development of pre-neoplastic lesions through an estrogen receptor beta (ERbeta) mediated mechanism in mice.	Estradiol	37-46	estrogen receptor 2 (beta)	Mus musculus	138-144
22041555-7	2012	Pretreatment of mice with the selective estrogen receptor (ER), ERalpha- and ERbeta antagonist ICI 182,780, led to a complete block of RSV effect on DAT protein levels, suggesting that ERs are involved in the up-regulation of DAT by RSV.	Resveratrol	233-236	estrogen receptor 2 (beta)	Mus musculus	77-83
22307635-1	2012	An estrogen receptor (ER) beta ligand (LY3201) with a preference for ERbeta over ERalpha was administered in s.c. pellets releasing 0.04 mg/d.	LY3201	39-45	estrogen receptor 2 (beta)	Mus musculus	69-75
22307635-10	2012	The data reveal that treatment with a selective ERbeta agonist results in changes opposite to those reported in estradiol-17beta-treated mice and suggests that ERalpha and ERbeta play opposing roles in the brain.	Estradiol	112-121	estrogen receptor 2 (beta)	Mus musculus	48-54
22307635-10	2012	The data reveal that treatment with a selective ERbeta agonist results in changes opposite to those reported in estradiol-17beta-treated mice and suggests that ERalpha and ERbeta play opposing roles in the brain.	Estradiol	112-121	estrogen receptor 2 (beta)	Mus musculus	172-178
22307635-10	2012	The data reveal that treatment with a selective ERbeta agonist results in changes opposite to those reported in estradiol-17beta-treated mice and suggests that ERalpha and ERbeta play opposing roles in the brain.	17beta	122-128	estrogen receptor 2 (beta)	Mus musculus	48-54
22307635-10	2012	The data reveal that treatment with a selective ERbeta agonist results in changes opposite to those reported in estradiol-17beta-treated mice and suggests that ERalpha and ERbeta play opposing roles in the brain.	17beta	122-128	estrogen receptor 2 (beta)	Mus musculus	172-178
22654841-4	2011	Importantly, rapid direct action of estradiol in GnRH neurons is mediated through membrane or membrane associated receptors, such as GPR30, STX-sensitive receptors, and ERbeta.	Estradiol	36-45	estrogen receptor 2 (beta)	Mus musculus	140-175
22808245-3	2012	Here we show two cycles of short-term ERbeta agonist (8beta-VE2) administration this treatment impairs regeneration, causing cystic atrophy that correlates with sustained depletion of p63+ basal cells.	8beta-ve2	54-63	estrogen receptor 2 (beta)	Mus musculus	38-44
22166976-9	2012	We conclude that the sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERalpha and ERbeta signaling.	bisphenol A	111-114	estrogen receptor 2 (beta)	Mus musculus	198-204
22166976-9	2012	We conclude that the sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERalpha and ERbeta signaling.	Estradiol	119-128	estrogen receptor 2 (beta)	Mus musculus	198-204
22041555-7	2012	Pretreatment of mice with the selective estrogen receptor (ER), ERalpha- and ERbeta antagonist ICI 182,780, led to a complete block of RSV effect on DAT protein levels, suggesting that ERs are involved in the up-regulation of DAT by RSV.	Resveratrol	135-138	estrogen receptor 2 (beta)	Mus musculus	77-83
22970307-3	2012	Here, we present evidence that reintroduction of ERbeta in BG-1 epithelial ovarian cancer cells, which express ERalpha, leads in vitro to a decrease of basal and estradiol-promoted cell proliferation.	Estradiol	162-171	estrogen receptor 2 (beta)	Mus musculus	49-55
22347437-3	2012	Here we used ERbeta-/- mice to study whether ERbeta is involved in the rapid regulation of K(ATP) channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM).	Calcium	116-123	estrogen receptor 2 (beta)	Mus musculus	45-51
22347437-8	2012	Our findings suggest that BPA behaves as a strong estrogen via nuclear ERbeta and indicate that results obtained with BPA in mouse beta-cells may be extrapolated to humans.	bisphenol A	26-29	estrogen receptor 2 (beta)	Mus musculus	71-77
22253831-2	2012	17beta-estradiol (E2) acting via ERbeta augments the actions of follicle stimulating hormone in granulosa cells, leading to granulosa cell differentiation and formation of a preovulatory follicle.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	33-39
21971047-12	2011	Overexpression of ERalpha or knockdown of ERbeta enhanced the effects of E2 on the levels of USP19, MHC, and tropomyosin, whereas knockdown of ERalpha, overexpression of ERbeta, or an ERbeta-selective agonist diarylpropionitrile abolished their effects.	diarylpropionitrile	209-228	estrogen receptor 2 (beta)	Mus musculus	42-48
22347437-3	2012	Here we used ERbeta-/- mice to study whether ERbeta is involved in the rapid regulation of K(ATP) channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM).	bisphenol A	198-201	estrogen receptor 2 (beta)	Mus musculus	45-51
21901819-7	2011	To identify the ER subtype mediating the increase on MN differentiation, we incubated estradiol with the ER-alpha antagonist MPP or with the ER-beta blocker PHTPP.	PHTPP	157-162	estrogen receptor 2 (beta)	Mus musculus	141-148
22016564-10	2011	Reintroduction of ERbeta into ERbeta-deficient cells partly restored Glut4 transcription and stabilized low DNA methylation after treatment with the DNA demethylating agent 5-Aza-2"-deoxycytidine.	Decitabine	173-195	estrogen receptor 2 (beta)	Mus musculus	18-24
22016564-10	2011	Reintroduction of ERbeta into ERbeta-deficient cells partly restored Glut4 transcription and stabilized low DNA methylation after treatment with the DNA demethylating agent 5-Aza-2"-deoxycytidine.	Decitabine	173-195	estrogen receptor 2 (beta)	Mus musculus	30-36
21624456-4	2011	Using organ cultures of fetal testes from wild type and ERalpha or ERbeta knock-out mice we show that genistein inhibits testosterone secretion by fetal Leydig cells during early fetal development (E12.5), within the "masculinization programming window".	Genistein	102-111	estrogen receptor 2 (beta)	Mus musculus	67-73
22088592-9	2011	ERbeta, instead of ERalpha, participates in the action of daidzein in regulating SRC-1 expression.	daidzein	58-66	estrogen receptor 2 (beta)	Mus musculus	0-6
21722721-6	2011	Microarray data showed 82 upregulated and 743 downregulated genes in the ovaries of fenarimol-exposed mice, in which Cyp17a1, Cyp19a1, and ERbeta were upregulated.	fenarimol	84-93	estrogen receptor 2 (beta)	Mus musculus	139-145
21636213-5	2011	Our results show that the ERbeta selective agonist DPN significantly inhibits development of MB preneoplastic lesions when compared with untreated ovariectomized mice, restoring the final incidence to that observed in the intact controls, and that these effects were achieved via activation of anti-proliferative and pro-apototic pathways.	diarylpropionitrile	51-54	estrogen receptor 2 (beta)	Mus musculus	26-32
21636213-0	2011	The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.	diarylpropionitrile	35-54	estrogen receptor 2 (beta)	Mus musculus	4-26
21636213-0	2011	The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.	diarylpropionitrile	56-59	estrogen receptor 2 (beta)	Mus musculus	4-26
21705395-2	2011	This study aims to elucidate which estrogen receptor (ER) subtype, ERalpha or ERbeta, is involved in the regulation of triglyceride (TG) homeostasis in the liver.	Triglycerides	119-131	estrogen receptor 2 (beta)	Mus musculus	78-84
21664404-7	2011	Although there was no significant change in serum testosterone levels and androgen receptor expression levels after treatment with different dosages of Aroclor 1254, the estradiol levels decreased and the expression of estrogen receptor (ER) beta increased in a dose-dependent manner, whereas an elevation of the expression of ERalpha was only observed in the 50mug/kg group.	Aroclors	152-159	estrogen receptor 2 (beta)	Mus musculus	219-246
21705395-2	2011	This study aims to elucidate which estrogen receptor (ER) subtype, ERalpha or ERbeta, is involved in the regulation of triglyceride (TG) homeostasis in the liver.	Triglycerides	133-135	estrogen receptor 2 (beta)	Mus musculus	78-84
21586296-13	2011	Hence, in male mice the lack of ERalpha or ERbeta altered their basal plasma steroid levels and both striatal DA transporters as well as their susceptibility to MPTP toxicity.	Steroids	77-84	estrogen receptor 2 (beta)	Mus musculus	43-49
21167702-0	2011	Soy isoflavones increase quinone reductase in hepa-1c1c7 cells via estrogen receptor beta and nuclear factor erythroid 2-related factor 2 binding to the antioxidant response element.	Isoflavones	4-15	estrogen receptor 2 (beta)	Mus musculus	67-89
21167702-5	2011	This study tested the hypothesis that genistein, daidzein and equol increase quinone reductase activity, protein and mRNA via ERbeta and Nrf2 binding to the QR antioxidant response element (ARE).	Genistein	38-47	estrogen receptor 2 (beta)	Mus musculus	126-132
21586296-13	2011	Hence, in male mice the lack of ERalpha or ERbeta altered their basal plasma steroid levels and both striatal DA transporters as well as their susceptibility to MPTP toxicity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	161-165	estrogen receptor 2 (beta)	Mus musculus	43-49
21502954-3	2011	Treating the cells with estradiol had minor effects on cell growth, whereas the selective ERbeta agonists diarylpropionitrile (DPN) and KB9520 showed a strong antiproliferative effect.	diarylpropionitrile	106-125	estrogen receptor 2 (beta)	Mus musculus	90-96
21683088-6	2011	In 3T3-L1 cells (which have no ERs), transiently transfected with the ERE-dependent reporter plus or minus ERalpha or ERbeta, TBT (in a dose range of 1-100nM) directly targets each ER subtype in a receptor-specific manner through a direct mechanism mediated by ERalpha in undifferentiated preadipocytic cells and by ERbeta in differentiating adipocytes.	tributyltin	126-129	estrogen receptor 2 (beta)	Mus musculus	316-322
21167702-5	2011	This study tested the hypothesis that genistein, daidzein and equol increase quinone reductase activity, protein and mRNA via ERbeta and Nrf2 binding to the QR antioxidant response element (ARE).	daidzein	49-57	estrogen receptor 2 (beta)	Mus musculus	126-132
21167702-11	2011	Furthermore, the study results demonstrate that genistein, daidzein and equol interact with the QR ARE and that daidzein and equol act via both ERbeta and Nrf2 binding strongly to the QR ARE.	Genistein	48-57	estrogen receptor 2 (beta)	Mus musculus	144-150
21167702-11	2011	Furthermore, the study results demonstrate that genistein, daidzein and equol interact with the QR ARE and that daidzein and equol act via both ERbeta and Nrf2 binding strongly to the QR ARE.	daidzein	112-120	estrogen receptor 2 (beta)	Mus musculus	144-150
21502954-3	2011	Treating the cells with estradiol had minor effects on cell growth, whereas the selective ERbeta agonists diarylpropionitrile (DPN) and KB9520 showed a strong antiproliferative effect.	diarylpropionitrile	127-130	estrogen receptor 2 (beta)	Mus musculus	90-96
21502954-3	2011	Treating the cells with estradiol had minor effects on cell growth, whereas the selective ERbeta agonists diarylpropionitrile (DPN) and KB9520 showed a strong antiproliferative effect.	kb9520	136-142	estrogen receptor 2 (beta)	Mus musculus	90-96
21477609-8	2011	An increase in ERbeta levels, with diminished ERalpha/ERbeta ratio, was observed in the tumors from mice treated with DPN/letrozole combination compared to single agents and control.	NAD	118-121	estrogen receptor 2 (beta)	Mus musculus	15-21
21477609-8	2011	An increase in ERbeta levels, with diminished ERalpha/ERbeta ratio, was observed in the tumors from mice treated with DPN/letrozole combination compared to single agents and control.	NAD	118-121	estrogen receptor 2 (beta)	Mus musculus	54-60
21477609-8	2011	An increase in ERbeta levels, with diminished ERalpha/ERbeta ratio, was observed in the tumors from mice treated with DPN/letrozole combination compared to single agents and control.	Letrozole	122-131	estrogen receptor 2 (beta)	Mus musculus	15-21
21477609-8	2011	An increase in ERbeta levels, with diminished ERalpha/ERbeta ratio, was observed in the tumors from mice treated with DPN/letrozole combination compared to single agents and control.	Letrozole	122-131	estrogen receptor 2 (beta)	Mus musculus	54-60
21477609-0	2011	Estrogen receptor-beta activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy.	Letrozole	119-128	estrogen receptor 2 (beta)	Mus musculus	0-22
21477609-6	2011	Our data further confirm that therapeutic activation of ERbeta by DPN, an ERbeta agonist, blocks letrozole-resistant tumor growth in a xenograft model.	NAD	66-69	estrogen receptor 2 (beta)	Mus musculus	56-62
21477609-6	2011	Our data further confirm that therapeutic activation of ERbeta by DPN, an ERbeta agonist, blocks letrozole-resistant tumor growth in a xenograft model.	NAD	66-69	estrogen receptor 2 (beta)	Mus musculus	74-80
21477609-6	2011	Our data further confirm that therapeutic activation of ERbeta by DPN, an ERbeta agonist, blocks letrozole-resistant tumor growth in a xenograft model.	Letrozole	97-106	estrogen receptor 2 (beta)	Mus musculus	56-62
21477609-6	2011	Our data further confirm that therapeutic activation of ERbeta by DPN, an ERbeta agonist, blocks letrozole-resistant tumor growth in a xenograft model.	Letrozole	97-106	estrogen receptor 2 (beta)	Mus musculus	74-80
21477609-7	2011	Interestingly, DPN exerted tumor growth inhibition only in the presence of the AI letrozole, suggesting that combination therapy including ERbeta activators and AI may be used in the clinical setting treating AI resistant breast cancer.	NAD	15-18	estrogen receptor 2 (beta)	Mus musculus	139-145
21377511-6	2011	As previously described, ERbeta KO females showed lower nociceptive responses compared to WT female mice during the interphase and early tonic phase 2 of the formalin test.	Formaldehyde	158-166	estrogen receptor 2 (beta)	Mus musculus	25-31
21377511-7	2011	The observed pronociceptive nature of ERbeta was confirmed using ERbeta-selective agonist DPN injections in ovariectomized mice.	dpn	90-93	estrogen receptor 2 (beta)	Mus musculus	38-44
21377511-7	2011	The observed pronociceptive nature of ERbeta was confirmed using ERbeta-selective agonist DPN injections in ovariectomized mice.	dpn	90-93	estrogen receptor 2 (beta)	Mus musculus	65-71
21285321-3	2011	Therefore we investigated whether the ERalpha agonist propyl pyrazole triol (PPT) and ERbeta agonist diarylpropionitrile (DPN) could affect social recognition, object recognition, or object placement learning within 40 min of drug administration.	diarylpropionitrile	101-120	estrogen receptor 2 (beta)	Mus musculus	86-92
21300662-0	2011	Estrogen receptor-beta signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice.	Desoxycorticosterone Acetate	92-119	estrogen receptor 2 (beta)	Mus musculus	0-22
21300662-0	2011	Estrogen receptor-beta signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice.	Salts	120-124	estrogen receptor 2 (beta)	Mus musculus	0-22
21300662-9	2011	Calcineurin Abeta expression and its positive regulator myocyte-enriched calcineurin-interacting protein 1 were increased in deoxycorticosterone acetate-salt female ERbeta(-/-) mice, yet lower than in WT males.	Desoxycorticosterone Acetate	125-152	estrogen receptor 2 (beta)	Mus musculus	165-171
21300662-11	2011	We conclude that a functional ERbeta is essential for inducing adaptive p38 and extracellular signal-regulated kinase signaling, while reducing maladaptive calcineurin signaling in normotensive deoxycorticosterone acetate female mice.	Desoxycorticosterone Acetate	194-221	estrogen receptor 2 (beta)	Mus musculus	30-36
21071029-9	2011	DHEA in vitro significantly promotes NO synthesis, suppresses MDA and MCP-1 secretion of endothelial cells, and decreases ICAM-1, VCAM-1 and E-selectin expression in HUVECs; neither selective ERalpha antagonist (methyl-piperidino-pyrazole, MPP) nor ERbeta antagonist (R,R-tetrahydrochrysene, R,RTHC) can abolish these effects.	Dehydroepiandrosterone	0-4	estrogen receptor 2 (beta)	Mus musculus	249-255
21293475-7	2011	E (10 mumol/L) also decreased troglitazone-induced PPARgamma reporter activity through both estrogen receptor (ER) alpha and ERbeta.	Troglitazone	30-42	estrogen receptor 2 (beta)	Mus musculus	125-131
20589455-4	2011	ER-beta protein was immunologically detected as a 53 kDa his-tag protein in the pellet of the bacterial lysate.	Histidine	57-60	estrogen receptor 2 (beta)	Mus musculus	0-7
21966501-0	2011	Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERalpha/ERbeta balance in female mice.	Nitric Oxide	55-67	estrogen receptor 2 (beta)	Mus musculus	104-110
20977477-0	2010	Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-beta.	Progesterone	0-12	estrogen receptor 2 (beta)	Mus musculus	98-120
20403091-8	2010	In addition, the mitochondrial transcription factor A and nuclear respiratory factor 1 were up-regulated by oestrogen in a similar way as MRCE in vitro, and ATP levels were elevated after the application of the specific ERbeta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile in cultured spinal cord nerve cells.	Adenosine Triphosphate	157-160	estrogen receptor 2 (beta)	Mus musculus	220-226
20557886-7	2010	ICI 182780, an estrogen receptor antagonist and R,R-THC, an estrogen receptor beta antagonist, counteracted the effect of 3beta-Adiol while bicalutamide, an androgen receptor antagonist, had minor effects.	(R,R)-THC	48-55	estrogen receptor 2 (beta)	Mus musculus	60-82
20557886-7	2010	ICI 182780, an estrogen receptor antagonist and R,R-THC, an estrogen receptor beta antagonist, counteracted the effect of 3beta-Adiol while bicalutamide, an androgen receptor antagonist, had minor effects.	Androstane-3,17-diol	122-133	estrogen receptor 2 (beta)	Mus musculus	60-82
20881113-6	2010	Only high doses (100 nm) of selective ERbeta agonist diarylpropionitrile (DPN) and GPR30 agonist G-1 induced estradiol-like [Ca(2+)](i) responses.	diarylpropionitrile	53-72	estrogen receptor 2 (beta)	Mus musculus	38-44
20881113-6	2010	Only high doses (100 nm) of selective ERbeta agonist diarylpropionitrile (DPN) and GPR30 agonist G-1 induced estradiol-like [Ca(2+)](i) responses.	diarylpropionitrile	74-77	estrogen receptor 2 (beta)	Mus musculus	38-44
20403091-8	2010	In addition, the mitochondrial transcription factor A and nuclear respiratory factor 1 were up-regulated by oestrogen in a similar way as MRCE in vitro, and ATP levels were elevated after the application of the specific ERbeta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile in cultured spinal cord nerve cells.	2,3-bis(4-hydroxyphenyl)-propionitrile	235-273	estrogen receptor 2 (beta)	Mus musculus	220-226
20034504-2	2010	The effects of estradiol are mediated by two classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).	Estradiol	15-24	estrogen receptor 2 (beta)	Mus musculus	112-134
20034504-2	2010	The effects of estradiol are mediated by two classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta).	Estradiol	15-24	estrogen receptor 2 (beta)	Mus musculus	136-142
20034504-3	2010	In 2005, G-protein-coupled receptor 30 (GPR30) was claimed to act as a non-classical estrogen receptor that was also activated by the ERalpha and ERbeta antagonists tamoxifen and fulvestrant (ICI 182780).	Tamoxifen	165-174	estrogen receptor 2 (beta)	Mus musculus	146-152
20668547-11	2010	The ERbeta agonists also increased calcium oscillations and phosphorylated PKC, AKT and ERK1/2 in neurons derived from mouse ES cells, which was inhibited by nifedipine demonstrating that ERbeta activates L-type voltage gated calcium channels to regulate neuronal activity.	Calcium	35-42	estrogen receptor 2 (beta)	Mus musculus	4-10
20668547-11	2010	The ERbeta agonists also increased calcium oscillations and phosphorylated PKC, AKT and ERK1/2 in neurons derived from mouse ES cells, which was inhibited by nifedipine demonstrating that ERbeta activates L-type voltage gated calcium channels to regulate neuronal activity.	Nifedipine	158-168	estrogen receptor 2 (beta)	Mus musculus	4-10
20668547-11	2010	The ERbeta agonists also increased calcium oscillations and phosphorylated PKC, AKT and ERK1/2 in neurons derived from mouse ES cells, which was inhibited by nifedipine demonstrating that ERbeta activates L-type voltage gated calcium channels to regulate neuronal activity.	Nifedipine	158-168	estrogen receptor 2 (beta)	Mus musculus	188-194
20079402-8	2010	Treatment with 17beta-estradiol (E(2), 100 nM) for 4 days increased ERbeta mRNA by about 8 times but had no effect on ERalpha mRNA level.	Estradiol	15-31	estrogen receptor 2 (beta)	Mus musculus	68-74
20206181-6	2010	The expressions of estrogen receptor beta (ERbeta) in both PND 21 and PND 56 mice were markedly down-regulated by BPA at 0.5, 5, and 50mg/kg/d.	bisphenol A	114-117	estrogen receptor 2 (beta)	Mus musculus	19-41
20206181-6	2010	The expressions of estrogen receptor beta (ERbeta) in both PND 21 and PND 56 mice were markedly down-regulated by BPA at 0.5, 5, and 50mg/kg/d.	bisphenol A	114-117	estrogen receptor 2 (beta)	Mus musculus	43-49
20553947-8	2010	The latter property remains dependent on EGFR, as pan-Erb (EGFR) inhibitor, CI-1033, blocks TF promoter activity and inhibits tumour formation by the parental and KSR1 overexpressing A431 cells.	Canertinib	76-83	estrogen receptor 2 (beta)	Mus musculus	54-57
20019181-4	2010	Phyto-oestrogens such as genistein, which preferentially activate ERbeta, have been shown to alleviate the ovarian phenotype of the oestrogen-depleted aromatase knockout mouse.	Genistein	25-34	estrogen receptor 2 (beta)	Mus musculus	66-72
20354658-8	2010	Homozygous Er-beta-/- mice supported the most rapid B16/F10 growth that was further accelerated by prior SSUV irradiation.	ssuv	105-109	estrogen receptor 2 (beta)	Mus musculus	11-18
19621276-10	2010	Then, this study suggests that HSP27 plays a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating caspase-3 activity and stabilizing ERbeta in skeletal muscle cells.	Estradiol	95-111	estrogen receptor 2 (beta)	Mus musculus	161-167
19910637-7	2010	Treatment of cells with a specific ERbeta agonist, diarylpropionitrile, revealed the same effect as E2 stimulation.	diarylpropionitrile	51-70	estrogen receptor 2 (beta)	Mus musculus	35-41
20068453-9	2010	In ER-[alpha] and ER-[beta] gene-deleted mice and controls estradiol-reduced functional injury (blood urea nitrogen: estradiol 117 +/- 71, vehicle 167 +/- 56, P = 0.007; creatinine: estradiol 0.5 +/- 0.5, vehicle 1.0 +/- 0.4, P = 0.013), but the effect of estradiol was not different between ER-[alpha] or ER-[beta] gene-deleted mice.	Estradiol	59-68	estrogen receptor 2 (beta)	Mus musculus	18-26
20068453-9	2010	In ER-[alpha] and ER-[beta] gene-deleted mice and controls estradiol-reduced functional injury (blood urea nitrogen: estradiol 117 +/- 71, vehicle 167 +/- 56, P = 0.007; creatinine: estradiol 0.5 +/- 0.5, vehicle 1.0 +/- 0.4, P = 0.013), but the effect of estradiol was not different between ER-[alpha] or ER-[beta] gene-deleted mice.	Estradiol	59-68	estrogen receptor 2 (beta)	Mus musculus	306-314
22242109-0	2010	Tissue-Dependent Expression of Estrogen Receptor beta in 17beta-Estradiol-Mediated Attenuation of Autoimmune CNS Inflammation.	Estradiol	57-73	estrogen receptor 2 (beta)	Mus musculus	31-53
19729610-6	2009	Mice treated with the ERbeta-specific agonist, DPN had no effect on uterine weight but a 28% decrease in aortic lesion area in HSP27(o/e)apoE(-/-) compared to apoE(-/-) mice.	NAD	47-50	estrogen receptor 2 (beta)	Mus musculus	22-28
19855088-0	2009	Rapid regulation of K(ATP) channel activity by 17{beta}-estradiol in pancreatic {beta}-cells involves the estrogen receptor {beta} and the atrial natriuretic peptide receptor.	Estradiol	47-65	estrogen receptor 2 (beta)	Mus musculus	106-130
19855088-6	2009	The effect of E2 was mimicked by the ERbeta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN).	2,3-bis(4-hydroxyphenyl)-propionitrile	52-90	estrogen receptor 2 (beta)	Mus musculus	37-43
19855088-6	2009	The effect of E2 was mimicked by the ERbeta agonist 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN).	NAD	92-95	estrogen receptor 2 (beta)	Mus musculus	37-43
19855088-7	2009	Activation of ERbeta by DPN enhanced glucose-induced Ca(2+) signals and insulin release.	NAD	24-27	estrogen receptor 2 (beta)	Mus musculus	14-20
19855088-7	2009	Activation of ERbeta by DPN enhanced glucose-induced Ca(2+) signals and insulin release.	Glucose	37-44	estrogen receptor 2 (beta)	Mus musculus	14-20
19675140-6	2009	Erb B2 activation contributed to the mechanical hypoalgesia and MNCV deficits in both diabetic genotypes because treatment with erlotinib or PKI 166 improved these indexes of DPN.	Erlotinib Hydrochloride	128-137	estrogen receptor 2 (beta)	Mus musculus	0-3
19553606-2	2009	We reported previously that the estrogen receptor beta (ESR2) mediates DES signaling in polyovular follicle induction.	Diethylstilbestrol	71-74	estrogen receptor 2 (beta)	Mus musculus	32-54
19553606-2	2009	We reported previously that the estrogen receptor beta (ESR2) mediates DES signaling in polyovular follicle induction.	Diethylstilbestrol	71-74	estrogen receptor 2 (beta)	Mus musculus	56-60
19832683-8	2009	These results indicate that ERbeta but not ERalpha is essential for DES to Induce PFs in mice.	Diethylstilbestrol	68-71	estrogen receptor 2 (beta)	Mus musculus	28-34
19832683-0	2009	Involvement of estrogen receptor beta in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol.	Diethylstilbestrol	118-136	estrogen receptor 2 (beta)	Mus musculus	15-37
19832683-3	2009	In this study, the involvement of estrogen receptor subtypes ERalpha and ERbeta in induction of PFs by neonatal treatment with DES was analyzed by using ERalpha knockout (alphaERKO) and ERbeta knockout (betaERKO) mice.	Diethylstilbestrol	127-130	estrogen receptor 2 (beta)	Mus musculus	73-79
19593916-3	2009	In-vitro assays show that trilostane may have actions through ERb.	trilostane	26-36	estrogen receptor 2 (beta)	Mus musculus	62-65
19593916-5	2009	We hypothesized that trilostane may exert antidepressive effects in the forced swim in part due to actions through ERb.	trilostane	21-31	estrogen receptor 2 (beta)	Mus musculus	115-118
19593916-7	2009	Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects.	trilostane	17-27	estrogen receptor 2 (beta)	Mus musculus	36-39
19581491-4	2009	METHODS AND RESULTS: We treated ovariectomized C57BL/6J mice with the ER-beta selective agonist 2,2-bis(4-hydroxyphenyl)-proprionitrile (DPN), 17beta-estradiol (E2), or vehicle using Alzet minipumps for 2 weeks.	2,2-bis(4-hydroxyphenyl)-proprionitrile	96-135	estrogen receptor 2 (beta)	Mus musculus	70-77
19581491-4	2009	METHODS AND RESULTS: We treated ovariectomized C57BL/6J mice with the ER-beta selective agonist 2,2-bis(4-hydroxyphenyl)-proprionitrile (DPN), 17beta-estradiol (E2), or vehicle using Alzet minipumps for 2 weeks.	NAD	137-140	estrogen receptor 2 (beta)	Mus musculus	70-77
19581491-7	2009	To test the specificity of DPN, we treated ER-beta-knockout mice with DPN.	NAD	70-73	estrogen receptor 2 (beta)	Mus musculus	43-50
19581491-8	2009	However, no cardioprotective effect of DPN was found in ER-beta-knockout mice, indicating that the DPN-induced cardioprotection occurs through the activation of ER-beta.	NAD	99-102	estrogen receptor 2 (beta)	Mus musculus	161-168
19627578-4	2009	Early (3 h) and late (24 h) responses to estrogen were evaluated and the participation of the estrogen receptors (ER), ERalpha and ERbeta, was analyzed by treating mice with propylpyrazole triol, a selective ERalpha agonist, or diarylpropionitrile, a selective agonist of ERbeta.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	174-194	estrogen receptor 2 (beta)	Mus musculus	131-137
19366879-5	2009	ERbeta-/- mice were characterized by fasting hypoglycemia, increased levels of SM GLUT4, pancreatic islet hypertrophy, and a belated rise in plasma insulin in response to a glucose challenge.	Glucose	173-180	estrogen receptor 2 (beta)	Mus musculus	0-6
19366879-10	2009	In ERbeta-/- mice, Tam did not affect GLUT4 in SM but acted as an ERalpha antagonist in WAT, decreasing GLUT4.	Tamoxifen	19-22	estrogen receptor 2 (beta)	Mus musculus	3-9
19324971-3	2009	As a result, FSH-primed ERbeta(-/-) granulosa cells exhibit a reduced response to a subsequent ovulatory dose of LH.	Luteinizing Hormone	113-115	estrogen receptor 2 (beta)	Mus musculus	24-30
19324971-7	2009	Our data indicate that this attenuated response may result from inadequate levels of cAMP, because cAMP levels in cultured ERbeta(-/-) granulosa cells exposed to forskolin were approximately 50% lower than in ERbeta(+/+) granulosa cells.	Colforsin	162-171	estrogen receptor 2 (beta)	Mus musculus	123-129
19101081-0	2009	The inhibitory effect of diarylpropionitrile, a selective agonist of estrogen receptor beta, on the growth of MC38 colon cancer line.	diarylpropionitrile	25-44	estrogen receptor 2 (beta)	Mus musculus	69-91
19428437-10	2009	These data raise the possibility that the antiapoptotic action of 17beta-estradiol in muscle cells may be related in part to a direct action of the hormone on mitochondria through ER beta.	Estradiol	66-82	estrogen receptor 2 (beta)	Mus musculus	180-187
19428988-11	2009	Both PPT, a specific ERalpha agonist, and DPN, a specific ERbeta agonist, inhibited GnRH gene expression in GN11 cells, but only DPN inhibited GnRH gene expression in GT1-7 cells, consistent with their undetectable levels of ERalpha expression.	NAD	42-45	estrogen receptor 2 (beta)	Mus musculus	58-64
19403828-14	2009	In contrast, ERbeta agonists increased GABA transmission and postsynaptic response.	gamma-Aminobutyric Acid	39-43	estrogen receptor 2 (beta)	Mus musculus	13-19
18562442-8	2009	In experiment 3, administration of E(2) or DPN to ovariectomised wildtype, but not betaERKO, mice decreased immobility compared with vehicle administration, these data suggest that ERbeta may be required for some of the anti-depressant-like effects of E(2).	Estradiol	35-39	estrogen receptor 2 (beta)	Mus musculus	181-187
18562442-8	2009	In experiment 3, administration of E(2) or DPN to ovariectomised wildtype, but not betaERKO, mice decreased immobility compared with vehicle administration, these data suggest that ERbeta may be required for some of the anti-depressant-like effects of E(2).	NAD	43-46	estrogen receptor 2 (beta)	Mus musculus	181-187
19279558-0	2009	17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes.	Estradiol	0-17	estrogen receptor 2 (beta)	Mus musculus	43-65
19279558-0	2009	17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes.	Tamoxifen	22-31	estrogen receptor 2 (beta)	Mus musculus	43-65
19101081-3	2009	The aim of this study was to examine the effect of various concentrations (10(-4)-10(-12)M) of diarylpropionitrile (DPN)--a selective agonist of ERbeta--on the growth of murine MC38 colon cancer line.	diarylpropionitrile	95-114	estrogen receptor 2 (beta)	Mus musculus	145-151
19101081-3	2009	The aim of this study was to examine the effect of various concentrations (10(-4)-10(-12)M) of diarylpropionitrile (DPN)--a selective agonist of ERbeta--on the growth of murine MC38 colon cancer line.	diarylpropionitrile	116-119	estrogen receptor 2 (beta)	Mus musculus	145-151
19159615-4	2009	BE360 showed a high binding affinity to estrogen receptors (ER), ERalpha and ERbeta.	be360	0-5	estrogen receptor 2 (beta)	Mus musculus	77-83
19189968-4	2009	ERbeta knockdown results in a lower resting mitochondrial membrane potential (Deltapsim) and increase in resistance to hydrogen peroxide-induced Deltapsim depolarization in both immortal hippocampal cells and primary hippocampal neurons.	Hydrogen Peroxide	119-136	estrogen receptor 2 (beta)	Mus musculus	0-6
19189968-5	2009	ERbeta knockdown cells maintained ATP concentrations despite insults that compromise ATP production and produce less mitochondrial superoxide under oxidative stress.	Adenosine Triphosphate	34-37	estrogen receptor 2 (beta)	Mus musculus	0-6
19189968-5	2009	ERbeta knockdown cells maintained ATP concentrations despite insults that compromise ATP production and produce less mitochondrial superoxide under oxidative stress.	Adenosine Triphosphate	85-88	estrogen receptor 2 (beta)	Mus musculus	0-6
19189968-5	2009	ERbeta knockdown cells maintained ATP concentrations despite insults that compromise ATP production and produce less mitochondrial superoxide under oxidative stress.	Superoxides	131-141	estrogen receptor 2 (beta)	Mus musculus	0-6
18832649-8	2009	Vascular iNOS levels were decreased consistently when adding 1 nM 17beta-estradiol to aortic tissues from ER beta- but not ER alpha-knockout mice.	Estradiol	66-82	estrogen receptor 2 (beta)	Mus musculus	106-113
18926853-1	2009	17beta-Estradiol (E(2)) may influence cognitive and/or affective behavior in part via the beta isoform of the estrogen receptor (ERbeta).	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	129-135
18957991-0	2009	Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-beta.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	105-127
18957991-7	2009	In protocol 2, treatment with ER-beta agonist DPN reduced neuronal injury in the striatum (51%+/-13% injured neurons) as compared with ER-alpha agonist PPT (68%+/-10%) and vehicle (69%+/-11%; P<0.01).	diarylpropionitrile	46-49	estrogen receptor 2 (beta)	Mus musculus	30-37
18957991-8	2009	Estrogen receptor-beta agonist DPN reduced neuronal injury in the hippocampal CA1 field (29%+/-22% injured neurons) as compared with ER-alpha agonist PPT treatment (62%+/-33%; P<0.05).	diarylpropionitrile	31-34	estrogen receptor 2 (beta)	Mus musculus	0-22
19027052-9	2009	The apoptotic effects of beta-naphthoflavone were accompanied by increased levels of AhRs, and these receptors colocalized with ERbeta as demonstrated by confocal microscopy.	beta-Naphthoflavone	25-44	estrogen receptor 2 (beta)	Mus musculus	128-134
18690485-12	2009	Furthermore, DHEA increased uterine ERbeta and ERalpha, and ERbeta transcription in the tibia, while E2 increased ERalpha transcription in the uterus and tibia.	Dehydroepiandrosterone	13-17	estrogen receptor 2 (beta)	Mus musculus	36-42
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	Diethylstilbestrol	75-78	estrogen receptor 2 (beta)	Mus musculus	47-53
18612317-11	2008	Estradiol depresses the brain"s protective response to IsoPC and may exacerbate cortical ischemic injury mainly through an ERbeta-dependent mechanism.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	123-129
18752649-6	2008	Treatment of male or female gonadectomised mice with oestradiol benzoate for 24 h substantially reduced the number of ERbeta-IR neurones, but not ERalpha-IR neurones.	estradiol 3-benzoate	53-72	estrogen receptor 2 (beta)	Mus musculus	118-124
18769638-1	2008	Although administration of 17beta-estradiol (estrogen) following trauma-hemorrhage attenuates the elevation of cytokine production and mitogen-activated protein kinase (MAPK) activation in epidermal keratinocytes, whether the salutary effects of estrogen are mediated by estrogen receptor (ER)-alpha or ER-beta is not known.	Estradiol	27-43	estrogen receptor 2 (beta)	Mus musculus	303-310
18584035-3	2008	To characterize the metabolic function of ERbeta, we investigated its molecular interaction with a master regulator of insulin signaling/glucose metabolism, the PPARgamma, in vitro and in high-fat diet (HFD)-fed ERbeta -/- mice (betaERKO) mice.	Glucose	137-144	estrogen receptor 2 (beta)	Mus musculus	42-48
18691380-3	2008	Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells.	Genistein	0-9	estrogen receptor 2 (beta)	Mus musculus	69-75
18687377-6	2008	Estrogen receptor (ER-alpha and ER-beta) levels in testes of the mice exposed to TBT were decreased in a dose-dependent manner.	tributyltin	81-84	estrogen receptor 2 (beta)	Mus musculus	32-39
18004284-5	2008	The present study investigated the effect of the ERalpha selective agonist PPT (1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole) and the ERbeta selective agonist WAY-200070 (7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol) on the STFP.	WAY 200070	163-173	estrogen receptor 2 (beta)	Mus musculus	138-144
18455477-5	2008	The mnemonic effects of 3*-diol are mediated in part through the beta isoform of estrogen receptors (ERbeta) in the hippocampus.	3*-diol	24-31	estrogen receptor 2 (beta)	Mus musculus	101-107
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	Diethylstilbestrol	75-78	estrogen receptor 2 (beta)	Mus musculus	172-178
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	diarylpropionitrile	188-207	estrogen receptor 2 (beta)	Mus musculus	172-178
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	NAD	209-212	estrogen receptor 2 (beta)	Mus musculus	172-178
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	Diethylstilbestrol	324-327	estrogen receptor 2 (beta)	Mus musculus	172-178
18835417-5	2008	Transactivation assays using mouse ERalpha and ERbeta showed that 10(-10)M DES activated both ER subtypes and that the ERalpha agonist (propyl pyrazole triol, PPT) and the ERbeta agonist (diarylpropionitrile, DPN) selectively activated their respective ERs at 10(-9)M. Neonatal female mice were injected subcutaneously with DES, PPT or DPN and the animals were examined at 13 and 15 weeks of age, respectively.	NAD	336-339	estrogen receptor 2 (beta)	Mus musculus	172-178
18339713-11	2008	Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels.	Diethylstilbestrol	167-170	estrogen receptor 2 (beta)	Mus musculus	8-14
18339713-11	2008	Because ERbeta may modulate ERalpha activation and have an antiproliferative function in the uterus, we hypothesize that ENERKI animals were particularly sensitive to DES-induced inhibition of ERalpha due to up-regulated uterine ERbeta levels.	Diethylstilbestrol	167-170	estrogen receptor 2 (beta)	Mus musculus	229-235
17962348-0	2008	17beta-estradiol at physiological concentrations augments Ca(2+) -activated K+ currents via estrogen receptor beta in the gonadotropin-releasing hormone neuronal cell line GT1-7.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	92-114
18313947-5	2008	We hypothesized that if E(2) has mnemonic effects, in part, due to its actions at ERbeta, then WT mice administered E(2) or DPN would have improved performance compared to vehicle WT controls, which would not be different from betaERKO mice administered vehicle, E(2) or DPN.	Estradiol	24-28	estrogen receptor 2 (beta)	Mus musculus	82-88
18423777-0	2008	WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.	WAY 200070	0-10	estrogen receptor 2 (beta)	Mus musculus	35-57
18423777-16	2008	The effects of the selective ER beta agonist, WAY-200070, on dopamine and serotonin, the anxiolytic-like and antidepressant-like effects as well as the genotype specific effects on neurochemistry support that positive modulation of ER beta function may provide a novel treatment for affective disorders.	Serotonin	74-83	estrogen receptor 2 (beta)	Mus musculus	29-36
18406537-5	2008	We observe translocation of estrogen receptor beta (beta) to the plasma membrane 5 min after exposure to 17beta-estradiol, whereas estrogen receptor alpha (alpha) localization remains unchanged.	Estradiol	105-121	estrogen receptor 2 (beta)	Mus musculus	28-50
18406537-6	2008	Membrane localization of estrogen receptor beta is transient, selective for 17beta-estradiol, and is not blocked by ICI182,780.	Estradiol	76-92	estrogen receptor 2 (beta)	Mus musculus	25-47
18063692-2	2008	In this study, the roles played by the membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), and the intracellular estrogen receptors, estrogen receptor alpha (ERalpha) and beta (ERbeta), in 17beta-estradiol (E2)-induced thymic atrophy were distinguished by construction and the side-by-side comparison of GPR30-deficient mice with ERalpha and ERbeta gene-deficient mice.	Estradiol	204-220	estrogen receptor 2 (beta)	Mus musculus	192-198
17962348-6	2008	An ERbeta-selective agonist, 2,3-bis(4-hydroxyphenyl)-propionitrile, augmented the K(Ca) currents, although an ERalpha-selective agonist, 4,4",4""-[4-propyl-(1H)-pyrazole-1,3,5-triyl]tris-phenol, had no effect.	2,3-bis(4-hydroxyphenyl)-propionitrile	29-67	estrogen receptor 2 (beta)	Mus musculus	3-9
17962348-6	2008	An ERbeta-selective agonist, 2,3-bis(4-hydroxyphenyl)-propionitrile, augmented the K(Ca) currents, although an ERalpha-selective agonist, 4,4",4""-[4-propyl-(1H)-pyrazole-1,3,5-triyl]tris-phenol, had no effect.	k(ca)	83-88	estrogen receptor 2 (beta)	Mus musculus	3-9
17640960-6	2007	However, the activation of estrogen receptor (ER)-beta with a specific agonist, DPN [2,3-bis(4-hydroxyphenol)-propionitrile], prevented the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.	NAD	80-83	estrogen receptor 2 (beta)	Mus musculus	27-54
17628008-2	2007	For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-alpha and ERbeta.	Polyphenols	21-32	estrogen receptor 2 (beta)	Mus musculus	146-152
17628008-2	2007	For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-alpha and ERbeta.	Isoflavones	46-57	estrogen receptor 2 (beta)	Mus musculus	146-152
17628008-2	2007	For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-alpha and ERbeta.	Genistein	58-67	estrogen receptor 2 (beta)	Mus musculus	146-152
17628008-2	2007	For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-alpha and ERbeta.	daidzein	72-80	estrogen receptor 2 (beta)	Mus musculus	146-152
17850458-2	2007	To test the hypothesis that developmental exposure to oestradiol (E(2)) organises the quantity of adult oestrogen receptors (ERalpha and ERbeta), we used male mice with a targeted mutation of the aromatase enzyme gene (ArKO) and their wild-type (WT) littermates.	Estradiol	54-64	estrogen receptor 2 (beta)	Mus musculus	137-143
17951260-7	2007	Consistent with increased ERalpha and ERbeta expression, activin A stimulated estradiol-induced estrogen response element promoter activity.	Estradiol	78-87	estrogen receptor 2 (beta)	Mus musculus	38-44
17980496-7	2007	We found that nociceptive responses are lower in ERbeta KO female than in WT female mice during the interphase and early tonic phase II of the formalin test but not during acute and late tonic phases.	Formaldehyde	143-151	estrogen receptor 2 (beta)	Mus musculus	49-55
18314701-4	2007	However, the expression of the 2 types of estrogen receptor (ER), i.e., ER-alpha and ER-beta, in the spleen of infected mice of both sexes, was decreased by tamoxifen treatment.	Tamoxifen	157-166	estrogen receptor 2 (beta)	Mus musculus	85-92
17640960-6	2007	However, the activation of estrogen receptor (ER)-beta with a specific agonist, DPN [2,3-bis(4-hydroxyphenol)-propionitrile], prevented the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.	2,3-bis(4-hydroxyphenol)-propionitrile	85-123	estrogen receptor 2 (beta)	Mus musculus	27-54
17640960-6	2007	However, the activation of estrogen receptor (ER)-beta with a specific agonist, DPN [2,3-bis(4-hydroxyphenol)-propionitrile], prevented the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.	Testosterone	197-209	estrogen receptor 2 (beta)	Mus musculus	27-54
17626201-5	2007	Estradiol may be involved in cerebellar neuronal circuit formation through promoting neuronal growth and neuronal synaptic contact, because the Purkinje cell expresses estrogen receptor-beta (ERbeta).	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	168-190
17604617-7	2007	Furthermore, experiments using THC (ERalpha-agonist and ERbeta-antagonist) clearly demonstrate the critical role of ERbeta in HER2/neu-mediated tumorigenesis.	Dronabinol	31-34	estrogen receptor 2 (beta)	Mus musculus	116-122
17660237-18	2007	This study suggests that ER beta may be involved in regulation of Leydig cell proliferation and testosterone production in the adult mouse testis.	Testosterone	96-108	estrogen receptor 2 (beta)	Mus musculus	25-32
17675339-6	2007	In the dorsolateral prostate, resveratrol significantly inhibited cell proliferation, increased androgen receptor, estrogen receptor-beta, and insulin-like growth factor-1 receptor, and significantly decreased insulin-like growth factor (IGF)-1 and phospho-extracellular regulating kinase 1 (phospho-ERK 1).	Resveratrol	30-41	estrogen receptor 2 (beta)	Mus musculus	115-137
17675339-10	2007	The decrease in cell proliferation and the potent growth factor, IGF-1, the down-regulation of downstream effectors, phospho-ERKs 1 and 2 and the increase in the putative tumor suppressor, estrogen receptor-beta, provide a biochemical basis for resveratrol suppressing prostate cancer development.	Resveratrol	245-256	estrogen receptor 2 (beta)	Mus musculus	189-211
17626201-5	2007	Estradiol may be involved in cerebellar neuronal circuit formation through promoting neuronal growth and neuronal synaptic contact, because the Purkinje cell expresses estrogen receptor-beta (ERbeta).	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	192-198
17449797-4	2007	Estradiol treatment of ovariectomized ER-beta(-/-) mice induced alveolar regeneration.	Estradiol	0-9	estrogen receptor 2 (beta)	Mus musculus	38-45
17408746-9	2007	ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action.	Cadmium	77-79	estrogen receptor 2 (beta)	Mus musculus	10-17
17408746-9	2007	ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action.	cd+mmi	92-98	estrogen receptor 2 (beta)	Mus musculus	10-17
16906639-3	2006	In the ER competitive binding assay, CCE showed higher affinity with ERbeta compared with ERalpha.	Carbamylcholine	37-40	estrogen receptor 2 (beta)	Mus musculus	69-75
17320868-3	2007	Utilizing primary mesencephalic neurons, we found expression of both estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) with a predominance of ERalpha on both dopamine neurons and astrocytes.	Dopamine	178-186	estrogen receptor 2 (beta)	Mus musculus	107-129
17320868-3	2007	Utilizing primary mesencephalic neurons, we found expression of both estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) with a predominance of ERalpha on both dopamine neurons and astrocytes.	Dopamine	178-186	estrogen receptor 2 (beta)	Mus musculus	131-137
17222059-7	2007	This, coupled with the finding that BPA exposure elicited no additional effects in ERbeta null females, suggests that BPA exerts its effect on the early oocyte by interfering with the actions of ERbeta.	bisphenol A	118-121	estrogen receptor 2 (beta)	Mus musculus	195-201
17684316-5	2007	The addition of DHT to (125)I-SHBG significantly inhibited (125)I-SHBG uptake in HT22-ER beta cells but not in HT22-ER alpha or HT22 wild-type cells.	Dihydrotestosterone	16-19	estrogen receptor 2 (beta)	Mus musculus	86-93
17420033-2	2007	This effect of estradiol is thought to be mediated by an interaction with estrogen receptors (ER), of which there are two: ERalpha and ERbeta.	Estradiol	15-24	estrogen receptor 2 (beta)	Mus musculus	135-141
17336162-3	2007	In contrast, diarylpropionitrile (ERbeta-selective agonist) administration significantly decreased serum anti-DNA IgG2b level but did not significantly affect serum levels of other anti-DNA IgG subclasses, serum total IgG or prolactin concentration, mortality or the occurrence of albuminuria.	diarylpropionitrile	13-32	estrogen receptor 2 (beta)	Mus musculus	34-40
17120206-4	2007	The effects of coumestrol on the cellular activities were analyzed by the mitochondrial tetrazolium (MTT) assay, secretion of alkaline phosphatase (ALP), intracellular calcium content (Ca), and the gene expression of bone matrix protein, estrogen receptors (ER-alpha, ER-beta), and osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL).	Coumestrol	15-25	estrogen receptor 2 (beta)	Mus musculus	268-275
17362982-1	2007	This study was designed to investigate whether treatment with an estrogen receptor-beta (ER-beta)-selective agonist (2,3-bis(4-hydroxyphenyl)-propionitrile, DPN) can provide cardioprotection in female mice lacking endogenous estrogen.	2,3-bis(4-hydroxyphenyl)-propionitrile	117-155	estrogen receptor 2 (beta)	Mus musculus	65-87
17362982-1	2007	This study was designed to investigate whether treatment with an estrogen receptor-beta (ER-beta)-selective agonist (2,3-bis(4-hydroxyphenyl)-propionitrile, DPN) can provide cardioprotection in female mice lacking endogenous estrogen.	2,3-bis(4-hydroxyphenyl)-propionitrile	117-155	estrogen receptor 2 (beta)	Mus musculus	89-96
17362982-1	2007	This study was designed to investigate whether treatment with an estrogen receptor-beta (ER-beta)-selective agonist (2,3-bis(4-hydroxyphenyl)-propionitrile, DPN) can provide cardioprotection in female mice lacking endogenous estrogen.	NAD	157-160	estrogen receptor 2 (beta)	Mus musculus	65-87
17362982-1	2007	This study was designed to investigate whether treatment with an estrogen receptor-beta (ER-beta)-selective agonist (2,3-bis(4-hydroxyphenyl)-propionitrile, DPN) can provide cardioprotection in female mice lacking endogenous estrogen.	NAD	157-160	estrogen receptor 2 (beta)	Mus musculus	89-96
17479667-4	2007	High doses of TOR treatment significantly increased the E2-induced ERbeta expression.	Toremifene	14-17	estrogen receptor 2 (beta)	Mus musculus	67-73
17113197-1	2007	Estrogen actions are mainly mediated by estrogen receptor (ER)alpha and ERbeta which in turn are regulated by several factors including age, sex and gonadal steroid hormones 17beta-estradiol and testosterone.	Steroids	157-173	estrogen receptor 2 (beta)	Mus musculus	72-78
17113197-1	2007	Estrogen actions are mainly mediated by estrogen receptor (ER)alpha and ERbeta which in turn are regulated by several factors including age, sex and gonadal steroid hormones 17beta-estradiol and testosterone.	Estradiol	174-190	estrogen receptor 2 (beta)	Mus musculus	72-78
17113197-5	2007	17beta-Estradiol supplementation reduces the transcription rate of ERalpha and ERbeta in all groups except in adult male while testosterone treatment down regulates the transcription rate of ERalpha and ERbeta in all groups.	17beta	0-6	estrogen receptor 2 (beta)	Mus musculus	79-85
17113197-5	2007	17beta-Estradiol supplementation reduces the transcription rate of ERalpha and ERbeta in all groups except in adult male while testosterone treatment down regulates the transcription rate of ERalpha and ERbeta in all groups.	17beta	0-6	estrogen receptor 2 (beta)	Mus musculus	203-209
17113197-5	2007	17beta-Estradiol supplementation reduces the transcription rate of ERalpha and ERbeta in all groups except in adult male while testosterone treatment down regulates the transcription rate of ERalpha and ERbeta in all groups.	Estradiol	7-16	estrogen receptor 2 (beta)	Mus musculus	79-85
17113197-5	2007	17beta-Estradiol supplementation reduces the transcription rate of ERalpha and ERbeta in all groups except in adult male while testosterone treatment down regulates the transcription rate of ERalpha and ERbeta in all groups.	Testosterone	127-139	estrogen receptor 2 (beta)	Mus musculus	203-209
17113197-10	2007	In case of ERbeta, 17beta-estradiol decreases the transcript level in all groups except adult male while testosterone treatment results in the down regulation of transcript level in all groups.	Estradiol	19-35	estrogen receptor 2 (beta)	Mus musculus	11-17
17113197-10	2007	In case of ERbeta, 17beta-estradiol decreases the transcript level in all groups except adult male while testosterone treatment results in the down regulation of transcript level in all groups.	Testosterone	105-117	estrogen receptor 2 (beta)	Mus musculus	11-17
17113197-11	2007	Thus these findings suggest differential effects of age, sex, 17beta-estradiol and testosterone supplementation on the transcription of mouse ER genes which may account for differences in the protein levels of ERalpha and ERbeta and their functions in the brain.	Estradiol	62-78	estrogen receptor 2 (beta)	Mus musculus	222-228
17113197-11	2007	Thus these findings suggest differential effects of age, sex, 17beta-estradiol and testosterone supplementation on the transcription of mouse ER genes which may account for differences in the protein levels of ERalpha and ERbeta and their functions in the brain.	Testosterone	83-95	estrogen receptor 2 (beta)	Mus musculus	222-228
17038424-0	2006	The oestrogen receptor beta contributes to sex related differences in endothelial function of murine small arteries via EDHF.	edhf	120-124	estrogen receptor 2 (beta)	Mus musculus	4-27
17038424-12	2006	The data suggest that in WT male mice, ERbeta reduces EDHF-mediated relaxation through gap junction communication.	edhf	54-58	estrogen receptor 2 (beta)	Mus musculus	39-45
17110437-4	2006	Sixteen hours after injection of 17beta-estradiol (E(2)), the number of BrdUrd-labeled cells increased 20-fold in WT mice and 80-fold in ERbeta(-/-) mice.	Estradiol	33-49	estrogen receptor 2 (beta)	Mus musculus	137-143
17110437-6	2006	In both untreated and E(2)-treated mice, ERalpha and ERbeta were colocalized in the nuclei of many stromal and glandular epithelial cells.	Estradiol	22-26	estrogen receptor 2 (beta)	Mus musculus	53-59
17034120-0	2006	Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia.	Benzopyrans	0-11	estrogen receptor 2 (beta)	Mus musculus	26-48
17034120-1	2006	Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays.	Benzopyrans	0-10	estrogen receptor 2 (beta)	Mus musculus	21-43
17034120-1	2006	Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays.	Benzopyrans	0-10	estrogen receptor 2 (beta)	Mus musculus	120-142
17034120-1	2006	Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays.	Benzopyrans	0-10	estrogen receptor 2 (beta)	Mus musculus	144-150
16857750-6	2006	Measurements of hormone receptor levels showed increased levels of progesterone receptor protein and estrogen receptor-beta mRNA in Gen-0.5-treated mice compared with controls; ERalpha expression was decreased after all doses of Gen treatment.	Genistein	132-135	estrogen receptor 2 (beta)	Mus musculus	101-123
16984883-2	2006	To investigate the mechanism of O-GlcNAc and O-phosphate"s reciprocal roles in modulating the degradation and activity of murine estrogen receptor beta (mER-beta), the conformational changes induced by O-GlcNAcylation and O-phosphorylation of Ser(16) in 17-mer model peptides corresponding to the N-terminal intrinsically disordered (ID) region of mER-beta were studied by NMR techniques, circular dichroism (CD), and molecular dynamics simulations.	o-glcnac	32-40	estrogen receptor 2 (beta)	Mus musculus	129-151
16984883-2	2006	To investigate the mechanism of O-GlcNAc and O-phosphate"s reciprocal roles in modulating the degradation and activity of murine estrogen receptor beta (mER-beta), the conformational changes induced by O-GlcNAcylation and O-phosphorylation of Ser(16) in 17-mer model peptides corresponding to the N-terminal intrinsically disordered (ID) region of mER-beta were studied by NMR techniques, circular dichroism (CD), and molecular dynamics simulations.	o-glcnac	32-40	estrogen receptor 2 (beta)	Mus musculus	153-161
16984883-2	2006	To investigate the mechanism of O-GlcNAc and O-phosphate"s reciprocal roles in modulating the degradation and activity of murine estrogen receptor beta (mER-beta), the conformational changes induced by O-GlcNAcylation and O-phosphorylation of Ser(16) in 17-mer model peptides corresponding to the N-terminal intrinsically disordered (ID) region of mER-beta were studied by NMR techniques, circular dichroism (CD), and molecular dynamics simulations.	Phosphates	45-56	estrogen receptor 2 (beta)	Mus musculus	129-151
16984883-2	2006	To investigate the mechanism of O-GlcNAc and O-phosphate"s reciprocal roles in modulating the degradation and activity of murine estrogen receptor beta (mER-beta), the conformational changes induced by O-GlcNAcylation and O-phosphorylation of Ser(16) in 17-mer model peptides corresponding to the N-terminal intrinsically disordered (ID) region of mER-beta were studied by NMR techniques, circular dichroism (CD), and molecular dynamics simulations.	Phosphates	45-56	estrogen receptor 2 (beta)	Mus musculus	153-161
16984883-2	2006	To investigate the mechanism of O-GlcNAc and O-phosphate"s reciprocal roles in modulating the degradation and activity of murine estrogen receptor beta (mER-beta), the conformational changes induced by O-GlcNAcylation and O-phosphorylation of Ser(16) in 17-mer model peptides corresponding to the N-terminal intrinsically disordered (ID) region of mER-beta were studied by NMR techniques, circular dichroism (CD), and molecular dynamics simulations.	Serine	243-246	estrogen receptor 2 (beta)	Mus musculus	129-151
16984883-5	2006	Thus, we postulate that the different changes of the local structure in the N-terminal S(15)STG(18) fragment of mER-beta caused by O-phosphate or O-GlcNAc modification might lead to the disturbances to the dynamic ensembles of the ID region of mER-beta, which is related to its modulatory activity.	Phosphates	131-142	estrogen receptor 2 (beta)	Mus musculus	112-120
16846835-5	2006	In contrast, ERbeta-selective agonist diarylpropionitrile (DPN) alone had no effect on thymic weight, cellularity or CD4/CD8 phenotype expression.	diarylpropionitrile	38-57	estrogen receptor 2 (beta)	Mus musculus	13-19
16984883-5	2006	Thus, we postulate that the different changes of the local structure in the N-terminal S(15)STG(18) fragment of mER-beta caused by O-phosphate or O-GlcNAc modification might lead to the disturbances to the dynamic ensembles of the ID region of mER-beta, which is related to its modulatory activity.	Phosphates	131-142	estrogen receptor 2 (beta)	Mus musculus	244-252
16984883-5	2006	Thus, we postulate that the different changes of the local structure in the N-terminal S(15)STG(18) fragment of mER-beta caused by O-phosphate or O-GlcNAc modification might lead to the disturbances to the dynamic ensembles of the ID region of mER-beta, which is related to its modulatory activity.	o-glcnac	146-154	estrogen receptor 2 (beta)	Mus musculus	112-120
16984883-5	2006	Thus, we postulate that the different changes of the local structure in the N-terminal S(15)STG(18) fragment of mER-beta caused by O-phosphate or O-GlcNAc modification might lead to the disturbances to the dynamic ensembles of the ID region of mER-beta, which is related to its modulatory activity.	o-glcnac	146-154	estrogen receptor 2 (beta)	Mus musculus	244-252
17048570-8	2006	CONCLUSION: S. tamariscina and it"s water part and n-butanol part have estrogenic activities, effect on ERbeta is greater than ERalpha.	Water	36-41	estrogen receptor 2 (beta)	Mus musculus	104-110
17048570-8	2006	CONCLUSION: S. tamariscina and it"s water part and n-butanol part have estrogenic activities, effect on ERbeta is greater than ERalpha.	1-Butanol	51-60	estrogen receptor 2 (beta)	Mus musculus	104-110
16627800-2	2006	17beta-estradiol (E2) plays an important role in this process because it can attenuate pressure overload hypertrophy via 2 distinct estrogen receptors (ERs): ERalpha and ERbeta.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	170-176
16434614-1	2006	The present experiments sought to determine the implication of estrogen receptors (ERalpha and ERbeta) and their interaction with insulin-like growth factor receptor (IGF-IR) signaling pathways in neuroprotection by estradiol against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity.	Estradiol	216-225	estrogen receptor 2 (beta)	Mus musculus	95-101
16603234-2	2006	The influence of estradiol via the ERbeta has been assessed using several methods: estrogen receptor knockout mice, specific ERbeta selective agonists, and phytoestrogens which preferentially bind to ERbeta rather than ERalpha.	Estradiol	17-26	estrogen receptor 2 (beta)	Mus musculus	35-41
15916834-2	2006	In the present study, we have examined the effect of age, sex and gonadal steroids (estrogen and testosterone) on the level of ERalpha and ERbeta in the cerebral cortex of AKR mice.	Steroids	74-82	estrogen receptor 2 (beta)	Mus musculus	139-145
15916834-2	2006	In the present study, we have examined the effect of age, sex and gonadal steroids (estrogen and testosterone) on the level of ERalpha and ERbeta in the cerebral cortex of AKR mice.	Testosterone	97-109	estrogen receptor 2 (beta)	Mus musculus	139-145
15916834-5	2006	ERbeta level decreased significantly with advancing age in both sexes, whereas 17beta-estradiol supplementation decreased ERalpha level in old male and increased in old female, it also increased ERbeta level in old male and adult female.	Estradiol	79-95	estrogen receptor 2 (beta)	Mus musculus	195-201
15916834-6	2006	On the other hand, testosterone treatment decreased ERalpha level significantly in old female and ERbeta level in adult female but increased ERbeta level in male mice of both ages.	Testosterone	19-31	estrogen receptor 2 (beta)	Mus musculus	98-104
15916834-6	2006	On the other hand, testosterone treatment decreased ERalpha level significantly in old female and ERbeta level in adult female but increased ERbeta level in male mice of both ages.	Testosterone	19-31	estrogen receptor 2 (beta)	Mus musculus	141-147
15916834-7	2006	Thus, these findings showed that the expression of ERalpha and ERbeta protein is differentially influenced by age, sex and gonadal steroids in the mouse cerebral cortex, suggesting differences in ER-mediated brain functions.	Steroids	131-139	estrogen receptor 2 (beta)	Mus musculus	63-69
16468032-4	2006	When the expression of estrogen receptor (ER) alpha and beta was assessed, an induction of ERbeta by DES was found predominantly in PRL cells.	Diethylstilbestrol	101-104	estrogen receptor 2 (beta)	Mus musculus	91-97
16531562-0	2006	Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?	Estradiol	30-46	estrogen receptor 2 (beta)	Mus musculus	155-162
16563354-8	2006	Our conclusion is that ERbeta cannot be identified by MALDI-TOF from a mixture of mitochondrial proteins resolved on SDS-PAGE.	Sodium Dodecyl Sulfate	117-120	estrogen receptor 2 (beta)	Mus musculus	23-29
16356836-3	2006	We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls.	Resveratrol	141-152	estrogen receptor 2 (beta)	Mus musculus	112-118
16423895-6	2006	Upon treatment of ArKO mice with the ERbeta agonist 2,3-bis(4-hydroxyphenyl)propionitrile, GLUT4 expression was reduced.	2,3-bis(4-hydroxyphenyl)-propionitrile	52-89	estrogen receptor 2 (beta)	Mus musculus	37-43
16192398-3	2006	Previously, we have shown that mice treated neonatally with genistein, the primary soy phytoestrogen, have multi-oocyte follicles (MOFs), an effect apparently mediated by estrogen receptor 2 (ESR2, more commonly known as ERbeta).	Genistein	60-69	estrogen receptor 2 (beta)	Mus musculus	171-190
16192398-3	2006	Previously, we have shown that mice treated neonatally with genistein, the primary soy phytoestrogen, have multi-oocyte follicles (MOFs), an effect apparently mediated by estrogen receptor 2 (ESR2, more commonly known as ERbeta).	Genistein	60-69	estrogen receptor 2 (beta)	Mus musculus	192-196
16192398-3	2006	Previously, we have shown that mice treated neonatally with genistein, the primary soy phytoestrogen, have multi-oocyte follicles (MOFs), an effect apparently mediated by estrogen receptor 2 (ESR2, more commonly known as ERbeta).	Genistein	60-69	estrogen receptor 2 (beta)	Mus musculus	221-227
16166216-9	2005	In conclusion, we have demonstrated that the SK11 Sc cell line contains functional AR and ERbeta and that treatment of the cells with their respective steroids results in an increase in the amount of their mRNAs.	Steroids	151-159	estrogen receptor 2 (beta)	Mus musculus	90-96
16166216-10	2005	Our results suggest that E2 or 3betaAdiol acting via ERbeta might modulate Sc function in vivo and that SK11 cells provide a useful model that can be used to complement studies using Sc selective gene ablation.	Androstane-3,17-diol	31-41	estrogen receptor 2 (beta)	Mus musculus	53-59
16190762-0	2005	Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.	5-[18f]fluoro-(2r,3s)-2,3-bis(4-hydroxyphenyl)pentanenitrile	62-122	estrogen receptor 2 (beta)	Mus musculus	16-38
16216990-6	2005	Compared with wild type, arteries from estrogen receptor-beta knockout male, but not female, mice demonstrated gender-specific enhancement of the response to phenylephrine (alpha1-adrenoceptor agonist), which was accompanied by elevated basal tension attributable to endothelial factors.	Phenylephrine	158-171	estrogen receptor 2 (beta)	Mus musculus	39-61
16007178-6	2005	The ERbeta-selective agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) inhibited cell growth and induced apoptosis.	2,3-bis(4-hydroxyphenyl)-propionitrile	29-68	estrogen receptor 2 (beta)	Mus musculus	4-10
16007178-6	2005	The ERbeta-selective agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) inhibited cell growth and induced apoptosis.	NAD	70-73	estrogen receptor 2 (beta)	Mus musculus	4-10
16007178-9	2005	When ERbeta expression was blocked, E2 induced proliferation and cells gained the capacity to grow in soft agar.	Agar	107-111	estrogen receptor 2 (beta)	Mus musculus	5-11
16264406-3	2005	We developed a glial cell model for ER function using the N20.1 mouse oligodendroglial cell line to evaluate the response of ERalpha and ERbeta to estradiol (E2), a raloxifene analog LY117018 (LY) and 4-hydroxytamoxifen (4OHT).	Estradiol	147-156	estrogen receptor 2 (beta)	Mus musculus	137-143
16190762-0	2005	Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.	16-fluoroestradiol	167-203	estrogen receptor 2 (beta)	Mus musculus	16-38
16190762-4	2005	To develop an imaging agent for ERbeta, we synthesized a fluoroethyl analogue of DPN (2,3-bis(4-hydroxyphenyl)propanonitrile), a known ERbeta-selective ligand.	NAD	81-84	estrogen receptor 2 (beta)	Mus musculus	32-38
16190762-4	2005	To develop an imaging agent for ERbeta, we synthesized a fluoroethyl analogue of DPN (2,3-bis(4-hydroxyphenyl)propanonitrile), a known ERbeta-selective ligand.	NAD	81-84	estrogen receptor 2 (beta)	Mus musculus	135-141
16190762-4	2005	To develop an imaging agent for ERbeta, we synthesized a fluoroethyl analogue of DPN (2,3-bis(4-hydroxyphenyl)propanonitrile), a known ERbeta-selective ligand.	2,3-bis(4-hydroxyphenyl)propanonitrile	86-124	estrogen receptor 2 (beta)	Mus musculus	32-38
16190762-4	2005	To develop an imaging agent for ERbeta, we synthesized a fluoroethyl analogue of DPN (2,3-bis(4-hydroxyphenyl)propanonitrile), a known ERbeta-selective ligand.	2,3-bis(4-hydroxyphenyl)propanonitrile	86-124	estrogen receptor 2 (beta)	Mus musculus	135-141
16190762-5	2005	This analogue, FEDPN (5-fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile), has an 8.3-fold absolute affinity preference for ERbeta.	fedpn	15-20	estrogen receptor 2 (beta)	Mus musculus	129-135
16190762-5	2005	This analogue, FEDPN (5-fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile), has an 8.3-fold absolute affinity preference for ERbeta.	5-fluoro-(2r,3s)-2,3-bis(4-hydroxyphenyl)pentanenitrile	22-77	estrogen receptor 2 (beta)	Mus musculus	129-135
16190762-8	2005	Experiments using ERalpha- and ERbeta-knockout mice demonstrated the expected ERalpha-subtype dependence in the tissue uptake of the known 16alpha-[18F]fluoro-17beta-estradiol ([18F]FES), which has a 6.3-fold preference for ERalpha.	16-fluoroestradiol	139-175	estrogen receptor 2 (beta)	Mus musculus	31-37
16190762-8	2005	Experiments using ERalpha- and ERbeta-knockout mice demonstrated the expected ERalpha-subtype dependence in the tissue uptake of the known 16alpha-[18F]fluoro-17beta-estradiol ([18F]FES), which has a 6.3-fold preference for ERalpha.	Iron	182-185	estrogen receptor 2 (beta)	Mus musculus	31-37
15898060-8	2005	Additional regional analyses in female mouse brain with PA1-310B antibody showed that a second, 59 kDa ERbeta-ir band was present in cortex, striatum, hippocampus, and amygdala that could represent one or both of the larger ERbeta variants (530 and 549aa).	pa1-310b	56-64	estrogen receptor 2 (beta)	Mus musculus	103-109
15845917-6	2005	Treatment of SJL mice with the ERalpha-selective agonist proteolipid protein (PPT) prior to the induction of disease resulted in suppression of clinical symptoms of disease, whereas treatment with an ERbeta-selective agonist (WAY-202041) had no effect.	ERB 041	226-236	estrogen receptor 2 (beta)	Mus musculus	200-206
15831568-4	2005	Granulosa cells of ERbeta knockout (ERKO) preovulatory follicles exhibited an attenuated response to FSH-induced differentiation, as evident by reduced aromatase activity and estradiol synthesis, and insufficient expression of LH receptor.	Estradiol	175-184	estrogen receptor 2 (beta)	Mus musculus	19-25
15831568-7	2005	These studies demonstrate that ERbeta-mediated estradiol actions are vital to FSH-induced granulosa cell differentiation; and in the absence of ERbeta, preovulatory follicles are deficient in the necessary cellular organization (i.e. antrum and cumulus oocyte complex), enzymatic activity (i.e. capacity to convert androgen precursor to estradiol), and receptor signaling pathways (i.e. LH receptor) to respond to a gonadotropin surge and expel a healthy oocyte.	Estradiol	47-56	estrogen receptor 2 (beta)	Mus musculus	31-37
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Estradiol	106-122	estrogen receptor 2 (beta)	Mus musculus	62-68
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Estradiol	106-122	estrogen receptor 2 (beta)	Mus musculus	230-236
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Estradiol	124-126	estrogen receptor 2 (beta)	Mus musculus	62-68
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Diethylstilbestrol	132-150	estrogen receptor 2 (beta)	Mus musculus	62-68
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Diethylstilbestrol	132-150	estrogen receptor 2 (beta)	Mus musculus	230-236
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Diethylstilbestrol	152-155	estrogen receptor 2 (beta)	Mus musculus	62-68
21783566-6	2005	Transient transfection of HeLa-mLF-Luc cells with ERalpha and ERbeta expression plasmids showed that both 17beta-estradiol (E2) and diethylstilbestrol (DES) at 10(-7)M significantly increased luciferase expression via ERalpha and ERbeta.	Diethylstilbestrol	152-155	estrogen receptor 2 (beta)	Mus musculus	230-236
15645223-0	2005	17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice.	Estradiol	3-17	estrogen receptor 2 (beta)	Mus musculus	90-112
15645223-2	2005	With respect to mood related disorders the interaction between ER-beta and the serotonin (5-HT) system is highly relevant.	Serotonin	79-88	estrogen receptor 2 (beta)	Mus musculus	63-70
15645223-3	2005	17beta-Estradiol (E2) induces expression of the enzyme implicated in 5-HT synthesis - tryptophan hydroxylase (TPH), and this effect is mediated through ER-beta located in 5-HT cell bodies of the dorsal raphe nucleus (DRN).	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	152-159
15645223-3	2005	17beta-Estradiol (E2) induces expression of the enzyme implicated in 5-HT synthesis - tryptophan hydroxylase (TPH), and this effect is mediated through ER-beta located in 5-HT cell bodies of the dorsal raphe nucleus (DRN).	Estradiol	18-20	estrogen receptor 2 (beta)	Mus musculus	152-159
15710898-2	2005	3betaAdiol is estrogenic in ERalpha or ERbeta positive cells only if they do not express CYP7B1.	Androstane-3,17-diol	0-10	estrogen receptor 2 (beta)	Mus musculus	39-45
15579483-11	2005	Immunoblot analyses also showed that expression of ERbeta was elevated in enterocytes of Min/+ OX mice treated with E(2) or coumestrol as compared with those of untreated Min/+ OX mice.	Estradiol	116-120	estrogen receptor 2 (beta)	Mus musculus	51-57
15579483-11	2005	Immunoblot analyses also showed that expression of ERbeta was elevated in enterocytes of Min/+ OX mice treated with E(2) or coumestrol as compared with those of untreated Min/+ OX mice.	Coumestrol	124-134	estrogen receptor 2 (beta)	Mus musculus	51-57
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	Genistein	33-42	estrogen receptor 2 (beta)	Mus musculus	93-99
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	Genistein	33-42	estrogen receptor 2 (beta)	Mus musculus	297-303
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	daidzein	44-52	estrogen receptor 2 (beta)	Mus musculus	93-99
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	daidzein	44-52	estrogen receptor 2 (beta)	Mus musculus	297-303
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	Zearalenone	58-69	estrogen receptor 2 (beta)	Mus musculus	93-99
15713532-4	2005	At sub-micromolar concentrations genistein, daidzein, and zearalenone stimulated ERalpha and ERbeta-dependent transcription in Neuro2A cells co-transfected with ERs and simple and complex estrogen-response-element (ERE) containing promoters, although compounds were more active in the presence of ERbeta.	Zearalenone	58-69	estrogen receptor 2 (beta)	Mus musculus	297-303
15642619-0	2005	Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice.	Serotonin	74-83	estrogen receptor 2 (beta)	Mus musculus	19-41
15642619-9	2005	We hypothesize that ERbeta is required during development to modulate the effects of estrogen on anxiety and catecholamine concentrations in female mouse brains.	Catecholamines	109-122	estrogen receptor 2 (beta)	Mus musculus	20-26
15471969-2	2005	Recent studies showed that 3betaAdiol binds to estrogen receptor (ER)-beta and regulates growth of the prostate gland through an estrogen, and not androgen, receptor-mediated pathway.	Androstane-3,17-diol	27-37	estrogen receptor 2 (beta)	Mus musculus	47-74
15579483-4	2005	Replacement of estradiol (E(2)) in ovariectomized Min/+ mice reduced tumor number to baseline and up-regulated the expression of estrogen receptor beta (ERbeta).	Estradiol	15-24	estrogen receptor 2 (beta)	Mus musculus	129-151
15579483-4	2005	Replacement of estradiol (E(2)) in ovariectomized Min/+ mice reduced tumor number to baseline and up-regulated the expression of estrogen receptor beta (ERbeta).	Estradiol	15-24	estrogen receptor 2 (beta)	Mus musculus	153-159
15710898-5	2005	We conclude that, by cell-specific regulation of the estrogenicity of 3betaAdiol, CYP7B1 performs two major tasks: (i) it allows 3betaAdiol to have growth inhibitory effects through ERbeta and (ii) it permits estradiol-specific activation of estrogen receptors by protection of certain cells from the estrogenic effects of 3betaAdiol.	Androstane-3,17-diol	70-80	estrogen receptor 2 (beta)	Mus musculus	182-188
15710898-5	2005	We conclude that, by cell-specific regulation of the estrogenicity of 3betaAdiol, CYP7B1 performs two major tasks: (i) it allows 3betaAdiol to have growth inhibitory effects through ERbeta and (ii) it permits estradiol-specific activation of estrogen receptors by protection of certain cells from the estrogenic effects of 3betaAdiol.	Androstane-3,17-diol	129-139	estrogen receptor 2 (beta)	Mus musculus	182-188
15710898-5	2005	We conclude that, by cell-specific regulation of the estrogenicity of 3betaAdiol, CYP7B1 performs two major tasks: (i) it allows 3betaAdiol to have growth inhibitory effects through ERbeta and (ii) it permits estradiol-specific activation of estrogen receptors by protection of certain cells from the estrogenic effects of 3betaAdiol.	Estradiol	209-218	estrogen receptor 2 (beta)	Mus musculus	182-188
15710898-5	2005	We conclude that, by cell-specific regulation of the estrogenicity of 3betaAdiol, CYP7B1 performs two major tasks: (i) it allows 3betaAdiol to have growth inhibitory effects through ERbeta and (ii) it permits estradiol-specific activation of estrogen receptors by protection of certain cells from the estrogenic effects of 3betaAdiol.	Androstane-3,17-diol	129-139	estrogen receptor 2 (beta)	Mus musculus	182-188
15215204-4	2004	In view of the recent localization of estrogen receptor beta (ERbeta) in primary spermatocytes and data suggesting the ability of ERbeta to repress cellular proliferation, we tested the hypothesis that variations in the testicular steroid microenvironment caused by excess ABP produce changes in ERbeta expression in this cellular type that could be associated to the meiotic arrest and, eventually, to the induction of germ cell apoptosis observed in the ABP transgenic mice.	Steroids	231-238	estrogen receptor 2 (beta)	Mus musculus	130-136
15664701-4	2005	Using dual-label immunocytochemistry for ER-alpha or ER-beta with tryptophan hydroxylase (TPH), the rate-limiting enzyme for 5-hydroxytryptamine (5-HT) synthesis, over 90% of ER-beta ir cells exhibited TPH-ir in all DRN subdivisions, whereas only 23% of ER-alpha ir cells contained TPH.	Serotonin	125-144	estrogen receptor 2 (beta)	Mus musculus	53-60
15215204-4	2004	In view of the recent localization of estrogen receptor beta (ERbeta) in primary spermatocytes and data suggesting the ability of ERbeta to repress cellular proliferation, we tested the hypothesis that variations in the testicular steroid microenvironment caused by excess ABP produce changes in ERbeta expression in this cellular type that could be associated to the meiotic arrest and, eventually, to the induction of germ cell apoptosis observed in the ABP transgenic mice.	Steroids	231-238	estrogen receptor 2 (beta)	Mus musculus	130-136
15353181-4	2004	ERalpha (66 kDa) and ERbeta (54 kDa) expression determined by Western blotting was unchanged within 7 h after inhibition of protein synthesis with cycloheximide in the absence of 17beta-estradiol (E(2)), showing that both proteins are stable without ligand-binding.	Estradiol	179-195	estrogen receptor 2 (beta)	Mus musculus	0-27
15231698-4	2004	Because ERbeta is highly expressed in granulosa cells of the ovary, we hypothesized the intraovarian actions of ERbeta may be necessary for full manifestation of phenotypes associated with LH hyperstimulation.	Luteinizing Hormone	189-191	estrogen receptor 2 (beta)	Mus musculus	8-14
15231698-4	2004	Because ERbeta is highly expressed in granulosa cells of the ovary, we hypothesized the intraovarian actions of ERbeta may be necessary for full manifestation of phenotypes associated with LH hyperstimulation.	Luteinizing Hormone	189-191	estrogen receptor 2 (beta)	Mus musculus	112-118
15256495-5	2004	Furthermore, because little is known regarding the role of each of the two known estrogen receptors (ERs) in microglia, our studies were designed to test the hypothesis that 17beta-estradiol (E(2)) exerts antiinflammatory effects in microglia, specifically via interactions with ERbeta.	Estradiol	174-190	estrogen receptor 2 (beta)	Mus musculus	279-285
15155257-4	2004	ERbeta agonist DPN significantly reduced ischemic damage by 70% in the caudate nucleus and 55% in the CA1 region compared with vehicle controls (P < 0.05, Mann-Whitney U-statistic).	dpn	15-18	estrogen receptor 2 (beta)	Mus musculus	0-6
15205372-0	2004	Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area.	Estradiol	33-42	estrogen receptor 2 (beta)	Mus musculus	0-22
15353181-7	2004	Treatment with the proteasome inhibitor epoxomicin (100 nM) for 3 days caused a prominent upregulation of ERalpha both in the absence and in the presence of E(2), while ERbeta was unaffected, suggesting that ERalpha but not ERbeta is degraded by ubiquitin-proteasome system in vascular smooth muscle cells.	epoxomicin	40-50	estrogen receptor 2 (beta)	Mus musculus	169-175
15353181-7	2004	Treatment with the proteasome inhibitor epoxomicin (100 nM) for 3 days caused a prominent upregulation of ERalpha both in the absence and in the presence of E(2), while ERbeta was unaffected, suggesting that ERalpha but not ERbeta is degraded by ubiquitin-proteasome system in vascular smooth muscle cells.	epoxomicin	40-50	estrogen receptor 2 (beta)	Mus musculus	224-230
15140561-8	2004	The current results strongly suggest that sex steroids can modulate the affective regulation of the serotonergic system through ERalpha and/or ERbeta in 5-HT neurons of the mouse rostral DRN (but not so much through AR), and that such effects might be different depending on the sex and species, as shown by the prominent sex differences in AR expression and prominent species differences in ERalpha and ERbeta expression.	Steroids	46-54	estrogen receptor 2 (beta)	Mus musculus	143-149
15140561-8	2004	The current results strongly suggest that sex steroids can modulate the affective regulation of the serotonergic system through ERalpha and/or ERbeta in 5-HT neurons of the mouse rostral DRN (but not so much through AR), and that such effects might be different depending on the sex and species, as shown by the prominent sex differences in AR expression and prominent species differences in ERalpha and ERbeta expression.	Steroids	46-54	estrogen receptor 2 (beta)	Mus musculus	404-410
15068509-16	2004	Activation of ERalpha or ERbeta by daidzein downregulated PPARgamma transcriptional activity but had no influence on PPARalpha or PPARdelta transcriptional activity.	daidzein	35-43	estrogen receptor 2 (beta)	Mus musculus	25-31
14715153-6	2004	The above results indicate that circulating sex steroids may differentially regulate the expression of ERbeta in the PVN of mice.	Steroids	48-56	estrogen receptor 2 (beta)	Mus musculus	103-109
15072576-1	2004	The steroid hormone, estrogen, plays an important role in various physiological events which are mediated via its nuclear estrogen receptors, ERalpha and ERbeta.	Steroids	4-19	estrogen receptor 2 (beta)	Mus musculus	154-160
14762170-8	2004	During 3 weeks of continuous E(2) treatment, ER beta remained in the nucleus, but there was no detectable ER alpha.	Estradiol	29-33	estrogen receptor 2 (beta)	Mus musculus	45-52
14762170-13	2004	By down-regulating ER beta, tamoxifen may prolong refractoriness to E(2) in mammary epithelium.	Tamoxifen	28-37	estrogen receptor 2 (beta)	Mus musculus	19-26
12915398-3	2003	ERalpha, ERbeta, and PR levels were higher in the aorta and ASMC of atherosclerosis-susceptible B6 mice.	asmc	60-64	estrogen receptor 2 (beta)	Mus musculus	9-15
12576490-2	2003	17Beta-estradiol (E2) and the antiestrogens 4-hydroxytamoxifen and ICI 182,780 induced reporter gene activity in MCF-7 and MDA-MB-231 cells cotransfected with human or mouse ERalpha (hERalpha or MOR), but not ERbeta and GC-rich constructs containing three tandem Sp1 binding sites (pSp13) or other E2-responsive GC-rich promoters.	Estradiol	0-16	estrogen receptor 2 (beta)	Mus musculus	209-215
12941152-5	2003	We show here that the 17-beta-oestradiol (E2)-induced downregulation of B lymphopoietic cells in bone marrow of young ovariectomized mice can be mediated through both ER-alpha and ER-beta.	Estradiol	22-40	estrogen receptor 2 (beta)	Mus musculus	180-187
12941152-5	2003	We show here that the 17-beta-oestradiol (E2)-induced downregulation of B lymphopoietic cells in bone marrow of young ovariectomized mice can be mediated through both ER-alpha and ER-beta.	Estradiol	42-44	estrogen receptor 2 (beta)	Mus musculus	180-187
14724952-2	2003	In the present study, the expression of ER-beta in the developing PVN of postnatal female mice was studied using nickel ammonium sulfate intensified immunocytochemical techniques, and the results showed that ER-beta immunopositive materials were predominantly localized in the magnocellular division of the PVN, only sparse positive cells were found in the parvocellular division and dorsal cap of the PVN.	ammonium nickel sulfate	113-136	estrogen receptor 2 (beta)	Mus musculus	40-47
12913761-8	2003	After capsaicin instillation the micturition interval and volume decreased, and micturition pressure increased in WT, ERbeta and 2 gene mice, while no changes were seen in ERKO mice.	Capsaicin	6-15	estrogen receptor 2 (beta)	Mus musculus	118-130
12727923-4	2003	In contrast, estradiol prevented ovariectomy-induced bone loss in ERbeta(-/-) mice, as in WT males and females, indicating that ERalpha is the major mediator of estradiol effects in bone.	Estradiol	13-22	estrogen receptor 2 (beta)	Mus musculus	66-72
12576490-2	2003	17Beta-estradiol (E2) and the antiestrogens 4-hydroxytamoxifen and ICI 182,780 induced reporter gene activity in MCF-7 and MDA-MB-231 cells cotransfected with human or mouse ERalpha (hERalpha or MOR), but not ERbeta and GC-rich constructs containing three tandem Sp1 binding sites (pSp13) or other E2-responsive GC-rich promoters.	hydroxytamoxifen	44-62	estrogen receptor 2 (beta)	Mus musculus	209-215
12573528-6	2003	Both in the MPOA and BNST, steroid hormone regulation of ERbeta protein (an increase by GDX and a decline to intact levels by EB) was found only in WT, not in alphaERKO mice.	Steroids	27-34	estrogen receptor 2 (beta)	Mus musculus	57-63
12573528-8	2003	EB treatment tended to decrease the number of ERbeta ir cells in WT mice, whereas EB treatment tended to increase ERbeta ir cell counts in alphaERKO mice.	estradiol 3-benzoate	0-2	estrogen receptor 2 (beta)	Mus musculus	46-52
12573528-8	2003	EB treatment tended to decrease the number of ERbeta ir cells in WT mice, whereas EB treatment tended to increase ERbeta ir cell counts in alphaERKO mice.	estradiol 3-benzoate	82-84	estrogen receptor 2 (beta)	Mus musculus	114-120
12573528-10	2003	These results suggest that gonadal steroid hormones may regulate ERbeta protein in male mice and ERalpha may be involved in the expression and regulation of ERbeta in a region-specific manner.	Steroids	35-42	estrogen receptor 2 (beta)	Mus musculus	65-71
12511606-11	2003	In contrast to E2 and selective ER modulators, the phytoestrogen, genistein was more effective at activating the mouse BMP-2 promoter with ERbeta, compared with ERalpha.	Genistein	66-75	estrogen receptor 2 (beta)	Mus musculus	139-145
12505546-3	2003	ER beta immunopositive cell numbers per testis section were significantly decreased in the 50 microg/ml bisphenol A-treated group compared with control and the 0.5 microg/ml bisphenol A-treated group.	bisphenol A	104-115	estrogen receptor 2 (beta)	Mus musculus	0-7
12505546-3	2003	ER beta immunopositive cell numbers per testis section were significantly decreased in the 50 microg/ml bisphenol A-treated group compared with control and the 0.5 microg/ml bisphenol A-treated group.	bisphenol A	174-185	estrogen receptor 2 (beta)	Mus musculus	0-7
12505546-6	2003	ER beta mRNA expression was significantly decreased in the 50 microg/ml bisphenol A-treated group compared with the control and the 0.5 microg/ml bisphenol A-treated group.	bisphenol A	72-83	estrogen receptor 2 (beta)	Mus musculus	0-7
12505546-6	2003	ER beta mRNA expression was significantly decreased in the 50 microg/ml bisphenol A-treated group compared with the control and the 0.5 microg/ml bisphenol A-treated group.	bisphenol A	146-157	estrogen receptor 2 (beta)	Mus musculus	0-7
11880592-11	2002	Genistein in the diet reduced the incidence of poorly differentiated prostatic adenocarcinomas in a dose-dependent manner and down-regulated androgen receptor, estrogen receptor-alpha, progesterone receptor, epidermal growth factor receptor, insulin-like growth factor-I, and extracellular signal-regulated kinase-1 but not estrogen receptor-beta and transforming growth factor-alpha mRNA expressions.	Genistein	0-9	estrogen receptor 2 (beta)	Mus musculus	324-383
12488333-1	2003	Leydig cells, which produce the primary male steroid hormone testosterone (T), express the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, and have the capacity to convert testosterone to the natural estrogen 17beta-estradiol.	Testosterone	181-193	estrogen receptor 2 (beta)	Mus musculus	140-146
12079510-3	2002	Expression of ER-beta mRNA was increased by the TOR treatment, compared with the control.	Toremifene	48-51	estrogen receptor 2 (beta)	Mus musculus	14-21
11884370-7	2002	Basal NO production was increased and the sensitivity to acetylcholine decreased in ERbeta knockout mice in response to E(2), whereas this effect was abolished in ERalpha knockout mice.	Acetylcholine	57-70	estrogen receptor 2 (beta)	Mus musculus	84-90
12370428-7	2002	Because CYP7B1 represents the major pathway for inactivating 3betaAdiol in the prostate, we suggest that ERbeta, 3betaAdiol, and CYP7B1 are the components of a pathway that regulates growth of the rodent ventral prostate.	Androstane-3,17-diol	61-71	estrogen receptor 2 (beta)	Mus musculus	105-111
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	58-68	estrogen receptor 2 (beta)	Mus musculus	17-23
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	58-68	estrogen receptor 2 (beta)	Mus musculus	75-81
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	58-68	estrogen receptor 2 (beta)	Mus musculus	75-81
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	173-183	estrogen receptor 2 (beta)	Mus musculus	17-23
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	173-183	estrogen receptor 2 (beta)	Mus musculus	75-81
12370428-8	2002	In this pathway, ERbeta is an antiproliferative receptor, 3betaAdiol is an ERbeta ligand, and CYP7B1 is the enzyme that regulates ERbeta function by regulating the level of 3betaAdiol.	Androstane-3,17-diol	173-183	estrogen receptor 2 (beta)	Mus musculus	75-81
12297547-0	2002	Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions.	Genistein	21-30	estrogen receptor 2 (beta)	Mus musculus	146-152
12297547-6	2002	Genistein-treated ERbeta knockout mice showed a similar induction of ERalpha, which is seen in CD-1 mice, suggesting that ERbeta does not mediate this effect.	Genistein	0-9	estrogen receptor 2 (beta)	Mus musculus	18-24
12215659-7	2002	Consistent with a role for E2 and ERalpha and ERbeta, treatment of DMBA-initiated female mice with topical ICI 182,780, an estrogen-receptor antagonist, reduced mirex tumor multiplicity by 30%.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	67-71	estrogen receptor 2 (beta)	Mus musculus	46-52
11971662-12	2002	These results suggest that ER-beta mediated actions of gonadal steroids may more profoundly be involved in the inhibitory regulation of aggressive behavior in pubertal and young adult mice.	Steroids	63-71	estrogen receptor 2 (beta)	Mus musculus	27-34
11891272-1	2002	Here we provide the first evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor beta (ERbeta).	Estradiol	59-68	estrogen receptor 2 (beta)	Mus musculus	129-151
11891272-1	2002	Here we provide the first evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor beta (ERbeta).	Estradiol	59-68	estrogen receptor 2 (beta)	Mus musculus	153-159
11955943-2	2002	BPA has been shown to bind weakly to both estrogen receptor (ER) alpha and ER beta.	bisphenol A	0-3	estrogen receptor 2 (beta)	Mus musculus	75-82
11784006-4	2001	The alphaERKO provides the potential to expose DES actions mediated by the second known ER, ERbeta, and those that are ER-independent.	Diethylstilbestrol	47-50	estrogen receptor 2 (beta)	Mus musculus	92-98
11739007-4	2001	In aorta from ovariectomized mice, treatment with the selective ER beta agonist genistein (100 nM) for 24 h increased [(3)H]leucine incorporation by about 30%.	Genistein	80-89	estrogen receptor 2 (beta)	Mus musculus	64-71
11739007-4	2001	In aorta from ovariectomized mice, treatment with the selective ER beta agonist genistein (100 nM) for 24 h increased [(3)H]leucine incorporation by about 30%.	Leucine	124-131	estrogen receptor 2 (beta)	Mus musculus	64-71
11509743-0	2001	Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.	Methoxychlor	44-56	estrogen receptor 2 (beta)	Mus musculus	88-94
11509743-0	2001	Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.	Estradiol	61-70	estrogen receptor 2 (beta)	Mus musculus	88-94
11509743-2	2001	The MXC metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) was previously shown to have selective agonist activity through estrogen receptor alpha (ERalpha) and antagonist activity through ERbeta and androgen receptor (AR).	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	19-65	estrogen receptor 2 (beta)	Mus musculus	203-209
11509743-2	2001	The MXC metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) was previously shown to have selective agonist activity through estrogen receptor alpha (ERalpha) and antagonist activity through ERbeta and androgen receptor (AR).	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	67-71	estrogen receptor 2 (beta)	Mus musculus	203-209
11509743-8	2001	Conversely, in the ovary, induction of cathepsin B by E2 was reversed after cotreatment with HPTE, and ERbeta expression was induced similarly by HPTE and FLU but not by E2.	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	146-150	estrogen receptor 2 (beta)	Mus musculus	103-109
11509743-8	2001	Conversely, in the ovary, induction of cathepsin B by E2 was reversed after cotreatment with HPTE, and ERbeta expression was induced similarly by HPTE and FLU but not by E2.	Flutamide	155-158	estrogen receptor 2 (beta)	Mus musculus	103-109
11371645-9	2001	This compound, which competes with E(2) for binding to ERbeta and elicits an estrogenic response in the aorta but not in the pituitary, decreases the AR content in prostates of wild-type mice but does not affect the elevated levels seen in ERbeta knockout (BERKO) mice.	Estradiol	35-39	estrogen receptor 2 (beta)	Mus musculus	55-61
11467885-7	2001	Unlike EB, which has comparable affinities for estrogen receptor (ER) alpha and ER beta, COUM has a higher affinity for ER beta than for ER alpha.	Coumestrol	89-93	estrogen receptor 2 (beta)	Mus musculus	120-127
11371645-10	2001	Thus ERbeta, probably as a complex with 3betaAdiol, is involved in regulating the AR content of the rodent prostate and in restraining epithelial growth.	Androstane-3,17-diol	40-50	estrogen receptor 2 (beta)	Mus musculus	5-11
11150304-0	2001	Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activity.	Serine	49-55	estrogen receptor 2 (beta)	Mus musculus	69-91
11150304-2	2001	Recently, we demonstrated that the murine estrogen receptor-beta (mER-beta) is alternatively O-GlcNAcylated or O-phosphorylated at Ser(16).	Serine	131-134	estrogen receptor 2 (beta)	Mus musculus	66-74
11150304-5	2001	Whereas, the mutant without hydroxyl amino acids at this locus is degraded at a slower rate, indicating that O-GlcNAc/O-phosphate at Ser(16) modulates mER-beta protein stability.	o-glcnac	109-117	estrogen receptor 2 (beta)	Mus musculus	151-159
11150304-5	2001	Whereas, the mutant without hydroxyl amino acids at this locus is degraded at a slower rate, indicating that O-GlcNAc/O-phosphate at Ser(16) modulates mER-beta protein stability.	Phosphates	118-129	estrogen receptor 2 (beta)	Mus musculus	151-159
11150304-5	2001	Whereas, the mutant without hydroxyl amino acids at this locus is degraded at a slower rate, indicating that O-GlcNAc/O-phosphate at Ser(16) modulates mER-beta protein stability.	Serine	133-136	estrogen receptor 2 (beta)	Mus musculus	151-159
11150304-6	2001	Luciferase reporter assays also show that the Ser(16) locus mutants have abnormal transactivation activities, suggesting that the two alternative modifications at Ser(16) on mER-beta may also be involved in transcriptional regulation.	Serine	46-49	estrogen receptor 2 (beta)	Mus musculus	174-182
11150304-6	2001	Luciferase reporter assays also show that the Ser(16) locus mutants have abnormal transactivation activities, suggesting that the two alternative modifications at Ser(16) on mER-beta may also be involved in transcriptional regulation.	Serine	163-166	estrogen receptor 2 (beta)	Mus musculus	174-182
11289129-8	2001	These results suggest that endogenous estrogens protect against Apc-associated tumor formation and that tumor prevention by 17beta-estradiol is associated with an increase in ERbeta and a decrease in ERalpha expression in the target tissue.	Estradiol	124-140	estrogen receptor 2 (beta)	Mus musculus	175-181
11150304-9	2001	It appears that reciprocal occupancy of Ser(16) by either O-phosphate or O-GlcNAc modulates the degradation and activity of mER-beta.	Serine	40-43	estrogen receptor 2 (beta)	Mus musculus	124-132
11150304-9	2001	It appears that reciprocal occupancy of Ser(16) by either O-phosphate or O-GlcNAc modulates the degradation and activity of mER-beta.	Phosphates	58-69	estrogen receptor 2 (beta)	Mus musculus	124-132
11150304-9	2001	It appears that reciprocal occupancy of Ser(16) by either O-phosphate or O-GlcNAc modulates the degradation and activity of mER-beta.	o-glcnac	73-81	estrogen receptor 2 (beta)	Mus musculus	124-132
11145618-0	2001	Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol.	Estradiol	72-81	estrogen receptor 2 (beta)	Mus musculus	0-22
11133684-9	2001	This study suggests that up-regulation of PR in endometrial stroma is mediated through at least three mechanisms: 1) classical estrogen signaling through ERalpha, 2) estrogen signaling through ERbeta, and 3) as a result of mechanical stimulation plus progesterone, which induces stromal cells to differentiate into decidual cells.	Progesterone	251-263	estrogen receptor 2 (beta)	Mus musculus	193-206
10995228-3	2000	Here, we report that estrogen receptor beta is alternatively modified by either O-GlcNAc or O-phosphate.	o-glcnac	80-88	estrogen receptor 2 (beta)	Mus musculus	21-43
11146419-9	2000	We also examined whether 17 beta-estradiol stimulates the transcriptional activity of the Y(1) receptor gene by binding to ER beta.	Estradiol	25-42	estrogen receptor 2 (beta)	Mus musculus	123-130
10995228-3	2000	Here, we report that estrogen receptor beta is alternatively modified by either O-GlcNAc or O-phosphate.	Phosphates	92-103	estrogen receptor 2 (beta)	Mus musculus	21-43
10995228-5	2000	Structural characterization of the carbohydrate moieties on mER-beta, overexpressed in insect Sf9 cells, confirmed the presence of O-GlcNAc.	Carbohydrates	35-47	estrogen receptor 2 (beta)	Mus musculus	60-68
10995228-5	2000	Structural characterization of the carbohydrate moieties on mER-beta, overexpressed in insect Sf9 cells, confirmed the presence of O-GlcNAc.	o-glcnac	131-139	estrogen receptor 2 (beta)	Mus musculus	60-68
10995228-7	2000	The major site of O-GlcNAc on mER-beta from Sf9 cells is Ser(16) near the N-terminus.	o-glcnac	18-26	estrogen receptor 2 (beta)	Mus musculus	30-38
10995228-7	2000	The major site of O-GlcNAc on mER-beta from Sf9 cells is Ser(16) near the N-terminus.	Serine	57-60	estrogen receptor 2 (beta)	Mus musculus	30-38
10995228-8	2000	Concomitant analyses also documented the O-phosphorylation of mER-beta at Ser(16).	Serine	74-77	estrogen receptor 2 (beta)	Mus musculus	62-70
10995228-10	2000	The localization of a major O-GlcNAc/O-phosphate site in proximity of the transactivation domain and as part of a PEST region (target sequences for rapid protein degradation) on mER-beta suggests that these modifications may play a role in regulating estrogen receptor beta transactivation and turnover.	o-glcnac	28-36	estrogen receptor 2 (beta)	Mus musculus	178-186
10995228-10	2000	The localization of a major O-GlcNAc/O-phosphate site in proximity of the transactivation domain and as part of a PEST region (target sequences for rapid protein degradation) on mER-beta suggests that these modifications may play a role in regulating estrogen receptor beta transactivation and turnover.	o-glcnac	28-36	estrogen receptor 2 (beta)	Mus musculus	251-273
10995228-10	2000	The localization of a major O-GlcNAc/O-phosphate site in proximity of the transactivation domain and as part of a PEST region (target sequences for rapid protein degradation) on mER-beta suggests that these modifications may play a role in regulating estrogen receptor beta transactivation and turnover.	Phosphates	37-48	estrogen receptor 2 (beta)	Mus musculus	178-186
10995228-10	2000	The localization of a major O-GlcNAc/O-phosphate site in proximity of the transactivation domain and as part of a PEST region (target sequences for rapid protein degradation) on mER-beta suggests that these modifications may play a role in regulating estrogen receptor beta transactivation and turnover.	Phosphates	37-48	estrogen receptor 2 (beta)	Mus musculus	251-273
10702625-7	2000	Both ERalpha and ERbeta bind 17beta-estradiol with high affinity and they bind to classical estrogen response elements in a similar if not identical fashion.	Estradiol	29-45	estrogen receptor 2 (beta)	Mus musculus	17-23
10819775-8	2000	Estrogen receptor-alpha and ER-beta mRNA and protein were also demonstrated in HAs by reverse transcription-polymerase chain reaction and double immunofluorescence, and treatment with 17beta-estradiol (17beta-E(2)) increased both active and latent TGF-beta(1) levels in HA CM.	Estradiol	184-200	estrogen receptor 2 (beta)	Mus musculus	28-35
10927637-3	2000	17beta-oestradiol was added to aortic rings from ERbeta knock-out (-/-) and wild-type (+/+) mice precontracted with noradrenaline.	Estradiol	0-17	estrogen receptor 2 (beta)	Mus musculus	49-55
10706629-5	2000	The ERbeta-MAD2 interaction was identified by screening of a yeast two-hybrid system vascular endothelial cell library with ERbeta and confirmed with glutathione S-transferase-fusion protein interaction studies.	Glutathione	150-161	estrogen receptor 2 (beta)	Mus musculus	4-10
10684871-5	2000	Surprisingly, both the ER-alpha selective ligand 16alpha-iodo-17beta-estradiol and the ER-beta selective ligand genistein failed to elicit ERK phosphorylation, suggesting that a different mechanism or receptor may mediate estrogen-induced ERK phosphorylation in the cerebral cortex.	Genistein	112-121	estrogen receptor 2 (beta)	Mus musculus	87-94
9058381-9	1997	Mutagenesis of a serine residue (position 60), located within a mitogen-activated protein kinase consensus phosphorylation site abolishes the stimulatory effect of Ras, suggesting that the activity of mER beta is also regulated by the mitogen-activated protein kinase pathway.	Serine	17-23	estrogen receptor 2 (beta)	Mus musculus	201-209
10611350-5	1999	Surprisingly, in ovariectomized female wild-type and ERbeta knockout mice, 17beta-estradiol markedly and equally inhibited the increase in vascular medial area and the proliferation of vascular smooth muscle cells after vascular injury.	Estradiol	75-91	estrogen receptor 2 (beta)	Mus musculus	53-59
10085099-2	1999	The present study demonstrates that CR-1 indirectly induces tyrosine phosphorylation of erb B-4 but not of the epidermal growth factor-related receptors erb B-2 and erb B-3 in different mouse and human mammary epithelial cell lines.	Tyrosine	60-68	estrogen receptor 2 (beta)	Mus musculus	88-91
9861029-4	1998	Here we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells.	Neomycin	102-110	estrogen receptor 2 (beta)	Mus musculus	48-70
9861029-4	1998	Here we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous recombination in embryonic stem cells.	Neomycin	102-110	estrogen receptor 2 (beta)	Mus musculus	72-78
9801392-9	1998	The residual responsiveness of ERalpha-disrupted mice to estradiol could be accounted for by an ERbeta-dependent mechanism or another as yet unidentified estrogen receptor; however, because ERalpha-immunoreactivity and PCR product representing the 3" end of ERalpha mRNA were found in at least one PR-containing region of the ERalpha-disrupted mice, an ERalpha splice variant may also mediate the induction of PR-immunoreactivity in ERalpha-disrupted mice.	Estradiol	57-66	estrogen receptor 2 (beta)	Mus musculus	96-102
10537130-9	1999	The recently reported ERalpha-specific agonist/ERbeta-specific antagonist 2,2-bis-(p-hydroxyphenyl-1,1,1-trichloroethane (HPTE), a methoxychlor metabolite, also down-regulated GnRH gene expression.	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	74-120	estrogen receptor 2 (beta)	Mus musculus	47-53
10537130-9	1999	The recently reported ERalpha-specific agonist/ERbeta-specific antagonist 2,2-bis-(p-hydroxyphenyl-1,1,1-trichloroethane (HPTE), a methoxychlor metabolite, also down-regulated GnRH gene expression.	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	122-126	estrogen receptor 2 (beta)	Mus musculus	47-53
10537130-9	1999	The recently reported ERalpha-specific agonist/ERbeta-specific antagonist 2,2-bis-(p-hydroxyphenyl-1,1,1-trichloroethane (HPTE), a methoxychlor metabolite, also down-regulated GnRH gene expression.	Methoxychlor	131-143	estrogen receptor 2 (beta)	Mus musculus	47-53
10433208-0	1999	Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism.	Methoxychlor	0-12	estrogen receptor 2 (beta)	Mus musculus	143-150
34884933-5	2021	Prenatal exposure to triclocarban also diminished the mRNA expression of Esr2, Gper1, Ahr, Arnt, Cyp19a1, Cyp1a1, and Atg7, and the protein levels of CAR, ARNT, and MAP1LC3AB in female brains and decreased the protein levels of BCL2, ARNT, and MAP1LC3AB in male brains.	triclocarban	21-33	estrogen receptor 2 (beta)	Mus musculus	73-77
27065803-8	2016	The ERbeta specific agonist DPN (10 pM) also significantly decreased the frequency of miniature postsynaptic currents (mPSCs) in GnRH neurons.	NAD	28-31	estrogen receptor 2 (beta)	Mus musculus	4-10
27065803-9	2016	In addition, the suppressive effect of E2 was completely blocked by the selective ERbeta antagonist PHTPP (1 muM) indicating that ERbeta is required for the observed rapid effect of the E2.	PHTPP	100-105	estrogen receptor 2 (beta)	Mus musculus	82-88
27065803-9	2016	In addition, the suppressive effect of E2 was completely blocked by the selective ERbeta antagonist PHTPP (1 muM) indicating that ERbeta is required for the observed rapid effect of the E2.	PHTPP	100-105	estrogen receptor 2 (beta)	Mus musculus	130-136
15037755-2	2004	In hypophysectomized rats and gonadotropin-releasing hormone antagonist-treated mice, the ERbeta agonist caused stimulation of early folliculogenesis, a decrease in follicular atresia, induction of ovarian gene expression, and stimulation of late follicular growth, accompanied by an increase in the number of ovulated oocytes similar to 17beta-estradiol (E2).	Estradiol	338-354	estrogen receptor 2 (beta)	Mus musculus	90-96
34807349-0	2022	Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-beta Signalling Pathway.	syringaresinol	0-14	estrogen receptor 2 (beta)	Mus musculus	91-114
34884750-9	2021	Furthermore, the estrogen receptors ERa and ERb were increased in the brain of prenatal D4-treated mice.	octamethylcyclotetrasiloxane	88-90	estrogen receptor 2 (beta)	Mus musculus	44-47
34807349-9	2022	SYR also suppressed LPS-induced pyroptosis in RAW 264.7 cells by inhibiting the activation of the NLRP3 inflammasome, which was abolished by an oestrogen receptor-beta (ERbeta) antagonist (PHTPP).	PHTPP	189-194	estrogen receptor 2 (beta)	Mus musculus	144-167
34260963-9	2021	Our findings also suggest that gene expression of estrogen receptor (Esr) 2 increased in the DRN might be associated with the reduction of ABB.	ABB	139-142	estrogen receptor 2 (beta)	Mus musculus	50-75
33618073-13	2021	In vitro studies demonstrated that 17beta-estradiol treatment upregulated FGF23 and Esr2 mRNAs in a dose-dependent manner.	Estradiol	35-51	estrogen receptor 2 (beta)	Mus musculus	84-88
33430527-0	2021	Estrogen and Glycemic Homeostasis: The Fundamental Role of Nuclear Estrogen Receptors ESR1/ESR2 in Glucose Transporter GLUT4 Regulation.	Glucose	99-106	estrogen receptor 2 (beta)	Mus musculus	91-95
33290273-8	2021	E2 augmented Treg expression of Foxp3, CD25 and GATA3, an effect that required ERb, and not ERa signaling.	Estradiol	0-2	estrogen receptor 2 (beta)	Mus musculus	79-82
31778582-8	2020	Moreover, estrogen receptors alpha (ERalpha) and beta (ERbeta) were highly expressed in MBP-positive mature oligodendrocytes.	Estrogens	10-18	estrogen receptor 2 (beta)	Mus musculus	55-61
31778582-10	2020	Furthermore, the donepezil-induced generation of mature oligodendrocytes from miPSC-NSC was significantly attenuated by antagonists and siRNA targeting ERalpha and ERbeta.	donepezil	17-26	estrogen receptor 2 (beta)	Mus musculus	164-170
31778582-11	2020	In conclusion, we demonstrated, for the first time, that donepezil-induced oligodendrogenesis is mediated through both ER subtypes, ERalpha and ERbeta.	donepezil	57-66	estrogen receptor 2 (beta)	Mus musculus	144-150