PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33175322-7	2021	Saracatinib, a nonselective Fyn inhibitor, has already been tested in clinical trials for Alzheimer"s disease, and novel selective Fyn inhibitors are under investigation.	saracatinib	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
33647348-4	2021	The molecular docking interaction analysis was done by exploring binding potential of flavonoids with kinases (PI3K, Akt, mTOR, EGFR, MAPK, MKK4, FYN, ZAP, BRAF, JAK- STAT1, STAT3, STAT4, STAT5, and VEGF) involved in various carcinogenesis phases.	Flavonoids	86-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	146-149
33647348-5	2021	Among flavonoids acacetin showed highest binding-energy against JAK-2 following FYN > VEGF > PI3K > MKK4 > MAPK > BRAF > STAT5 > STAT1 > STAT4 whereas pinostrobin depicts higher binding-energy with JAK-2 followed by BRAF > MKK4 > VEGF > PI3K > MAPK > STAT1 > STAT4 > STAT5.	acacetin	17-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
33647348-6	2021	Further, molecular-dynamic simulation revealed that pinostrobin interacted with JAK-2 protein with binding-energy of -25.068 +- 1.08 kJ/mol whereas acacetin interacted with both JAK-2 and Fyn with binding-energies of -23.466 +- 0.9508 kJ/mol and-8.935+-1.3108 kJ/mol respectively.	pinostrobin	52-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
33647348-6	2021	Further, molecular-dynamic simulation revealed that pinostrobin interacted with JAK-2 protein with binding-energy of -25.068 +- 1.08 kJ/mol whereas acacetin interacted with both JAK-2 and Fyn with binding-energies of -23.466 +- 0.9508 kJ/mol and-8.935+-1.3108 kJ/mol respectively.	acacetin	148-156	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
33883672-3	2021	In EGFR-overexpressing carcinoma cells, we found that the Src family kinase (SFK) inhibitor PP2 reduces beta4 tyrosine phosphorylation following the activation of EGFR.	pp2	92-95	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
33883672-3	2021	In EGFR-overexpressing carcinoma cells, we found that the Src family kinase (SFK) inhibitor PP2 reduces beta4 tyrosine phosphorylation following the activation of EGFR.	Tyrosine	110-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
34048194-1	2021	BACKGROUND: Rosmarinic acid (RA) is a natural phenolic compound that acts as a Fyn inhibitor by 53 homology modeling of the human Fyn structure.	rosmarinic acid	12-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
34048194-1	2021	BACKGROUND: Rosmarinic acid (RA) is a natural phenolic compound that acts as a Fyn inhibitor by 53 homology modeling of the human Fyn structure.	rosmarinic acid	12-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
34048194-1	2021	BACKGROUND: Rosmarinic acid (RA) is a natural phenolic compound that acts as a Fyn inhibitor by 53 homology modeling of the human Fyn structure.	rosmarinic acid	29-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
34048194-1	2021	BACKGROUND: Rosmarinic acid (RA) is a natural phenolic compound that acts as a Fyn inhibitor by 53 homology modeling of the human Fyn structure.	rosmarinic acid	29-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
33649774-2	2021	In the present study, the antitumor effects of rosmarinic acid (RA), a Fyn inhibitor, were explored in human-derived U251 and U343 glioma cell lines.	rosmarinic acid	47-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	71-74
33649774-2	2021	In the present study, the antitumor effects of rosmarinic acid (RA), a Fyn inhibitor, were explored in human-derived U251 and U343 glioma cell lines.	rosmarinic acid	64-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	71-74
33175322-5	2021	Accumulating preclinical evidence highlights the emerging role of Fyn in key aspects of PD and LID pathogenesis: it may regulate alpha-synuclein phosphorylation, oxidative stress-induced dopaminergic neuronal death, enhanced neuroinflammation and glutamate excitotoxicity by mediating key signaling pathways, such as BDNF/TrkB, PKCdelta, MAPK, AMPK, NF-kappaB, Nrf2, and NMDAR axes.	Glutamic Acid	247-256	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
33325804-6	2021	Moreover, TGF-beta1-induced activation of FYN involves initial activation of NOX4 and direct cysteine oxidation of FYN, and both FYN and mtROS contribute to TGF-beta-induced induction of NOX4.	Cysteine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
33325804-6	2021	Moreover, TGF-beta1-induced activation of FYN involves initial activation of NOX4 and direct cysteine oxidation of FYN, and both FYN and mtROS contribute to TGF-beta-induced induction of NOX4.	Cysteine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
33325804-4	2021	SFK activation by the profibrotic transforming growth factor-beta (TGF-beta) is thought to contribute to pulmonary fibrosis, but the relevant SFK isoform and its relation to NOX4 and/or mitochondrial ROS in the context of profibrotic TGF-beta signaling is not known.	Reactive Oxygen Species	200-203	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
33325804-6	2021	Moreover, TGF-beta1-induced activation of FYN involves initial activation of NOX4 and direct cysteine oxidation of FYN, and both FYN and mtROS contribute to TGF-beta-induced induction of NOX4.	Cysteine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
32905906-10	2020	FasL can recruit Fyn via the proline-rich domain leading to the recruitment of ADAP.	Proline	29-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
33451301-9	2021	CONCLUSIONS: These results showed that saracatinib can improve cognitive functions by reducing the loss of hippocampal neurons after SE, suggesting that Fyn dysfunction is involved in cognitive deficits after SE, and that the inhibition of Fyn is a possible treatment to improve cognitive function in SE patients.	saracatinib	39-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	153-156
32889002-0	2020	Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.	Eicosapentaenoic Acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	91-94
33314411-0	2021	Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the Identification of novel SH2 superbinders.	Phosphotyrosine	15-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
32959649-0	2020	Glucosylpolyphenols as inhibitors of Abeta-induced Fyn kinase activation and Tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the scope of type 2 diabetes and Alzheimer"s disease.	glucosylpolyphenols	0-19	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
33149591-7	2020	The serotonin 6 and 7 receptors are associated with schizophrenia via modulating cyclic adenosine monophosphate, regulation of Fyn kinase and induction of structural plasticity.	Serotonin	4-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	127-130
32959649-3	2020	Moreover, with the premise of Fyn kinase as a paradigm-shifting target in Alzheimer"s drug discovery, we explore glucosylpolyphenols as blockers of Abeta-induced Fyn kinase activation, while looking into downstream effects leading to Tau hyperphosphorylation.	glucosylpolyphenols	113-132	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	162-165
32959649-4	2020	Several compounds inhibit Abeta-induced Fyn kinase activation and decrease pTau levels at 10 muM concentration, particularly the per-O-methylated glucosylacetophloroglucinol and the 4-glucosylcatechol dibenzoate, the latter inhibiting also butyrylcholinesterase and beta-glucosidase.	per-o-methylated glucosylacetophloroglucinol	129-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
32606017-2	2020	The non-receptor tyrosine kinases FYN and ABL are known to drive phosphorylation of tyrosine residues in YXXP motifs within the intracellular domains of DCBLD family members, which leads to the recruitment of the Src homology 2 (SH2) domain of the adaptors CT10 regulator of kinase (CRK) and CRK-like (CRKL).	Tyrosine	17-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
30963942-6	2020	To get a deeper insight into the binding of quercetin with the SFK, a combined molecular dynamics and binding free energy calculations were performed.	Quercetin	44-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
32863204-3	2020	Here, we show that in red cells Fyn specifically stimulates G6PD activity, resulting in a 3-fold increase enzyme catalytic activity (kcat) by phosphorylating tyrosine (Tyr)-401.	Tyrosine	158-166	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	32-35
32863204-3	2020	Here, we show that in red cells Fyn specifically stimulates G6PD activity, resulting in a 3-fold increase enzyme catalytic activity (kcat) by phosphorylating tyrosine (Tyr)-401.	Tyrosine	168-171	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	32-35
32863204-4	2020	We found Tyr-401 on G6PD as functional target of Fyn in normal human red blood cells (RBC), being undetectable in G6PD deficient RBCs (G6PD-Mediterranean and G6PD-Genova).	Tyrosine	9-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
32863204-11	2020	In conclusion, our data suggest that Fyn is an oxidative radical sensor, and that Fyn-mediated Tyr-401 phosphorylation, by increasing G6PD activity, plays an important role in the physiology of RBCs.	Tyrosine	95-98	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
32751526-6	2020	Phosphorylation of APP at Tyr (pAPP-Tyr) increased in neurons of AD patients and AD neurons that exhibited high pAPP-Tyr also had higher Fyn TK activity.	Tyrosine	26-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
32751526-6	2020	Phosphorylation of APP at Tyr (pAPP-Tyr) increased in neurons of AD patients and AD neurons that exhibited high pAPP-Tyr also had higher Fyn TK activity.	papp-tyr	31-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
32751526-6	2020	Phosphorylation of APP at Tyr (pAPP-Tyr) increased in neurons of AD patients and AD neurons that exhibited high pAPP-Tyr also had higher Fyn TK activity.	LY 165163	31-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
32751526-6	2020	Phosphorylation of APP at Tyr (pAPP-Tyr) increased in neurons of AD patients and AD neurons that exhibited high pAPP-Tyr also had higher Fyn TK activity.	Tyrosine	36-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
32751526-7	2020	Fyn TK inhibition abolished the pAPP-Tyr and reduced Abeta42 secretion in AD neurons.	papp-tyr	32-40	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
32751526-8	2020	In addition, the multidomain adaptor protein Fe65 controlled the Fyn-mediated pAPP-Tyr, warranting the possibility of targeting the Fe65-APP-Fyn pathway to develop innovative strategies in AD.	papp-tyr	78-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
32751526-8	2020	In addition, the multidomain adaptor protein Fe65 controlled the Fyn-mediated pAPP-Tyr, warranting the possibility of targeting the Fe65-APP-Fyn pathway to develop innovative strategies in AD.	papp-tyr	78-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
32692785-7	2020	We found that TBB (a casein kinase II inhibitor), AR and LiCl (GSK-3 inhibitors), cyclosporin A (calcineurin inhibitor), and Saracatinib (Fyn kinase inhibitor) caused robust inhibition of OA-induced monomeric and oligomeric p-tau in both N2a and CTX culture.	2-ethylhexyl 2,3,4,5-tetrabromobenzoate	14-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
32692785-7	2020	We found that TBB (a casein kinase II inhibitor), AR and LiCl (GSK-3 inhibitors), cyclosporin A (calcineurin inhibitor), and Saracatinib (Fyn kinase inhibitor) caused robust inhibition of OA-induced monomeric and oligomeric p-tau in both N2a and CTX culture.	saracatinib	125-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
32291412-10	2020	Finally, through virtual screening, we identified amodiaquine as a potential inhibitor targeting the Fyn/CD147 axis.	Amodiaquine	50-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
32291412-11	2020	Amodiaquine treatment dramatically inhibited the phosphorylation of CD147 by Fyn, thus attenuating melanoma cell growth and invasion in vitro and in vivo, suggesting that amodiaquine is a promising inhibitor for melanoma treatment.	Amodiaquine	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
32291412-11	2020	Amodiaquine treatment dramatically inhibited the phosphorylation of CD147 by Fyn, thus attenuating melanoma cell growth and invasion in vitro and in vivo, suggesting that amodiaquine is a promising inhibitor for melanoma treatment.	Amodiaquine	171-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
32929078-0	2020	Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder.	Heroin	107-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	75-78
32929078-4	2020	FYN expression, kinase activity and the phosphorylation of its target Tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro.	Heroin	91-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
32929078-4	2020	FYN expression, kinase activity and the phosphorylation of its target Tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro.	Heroin	183-189	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
32929078-4	2020	FYN expression, kinase activity and the phosphorylation of its target Tau are increased by heroin use in the post-mortem human striatum, as well as in rats trained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro.	Morphine	240-248	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
32430486-0	2020	Perhexiline demonstrates FYN-mediated anti-tumor activity in glioblastoma.	Perhexiline	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
32430486-10	2020	Using in silico approaches, we identified FYN as a probable target of perhexiline and validated the role of this protein in perhexiline sensitivity.	Perhexiline	70-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
32430486-10	2020	Using in silico approaches, we identified FYN as a probable target of perhexiline and validated the role of this protein in perhexiline sensitivity.	Perhexiline	124-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
32430486-13	2020	Collectively, we identified potent FYN dependent anti-tumor activity of perhexiline in glioblastoma, thereby, representing a promising agent to be repurposed for the treatment of this devastating malignancy.	Perhexiline	72-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	35-38
32565740-0	2020	A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.	Chalcone	8-16	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	78-81
32565740-6	2020	To identify the potential inhibitors of Fyn, our in-house library including total of 111,277 chemicals was conducted to vitro screening, among those compounds, 83 inhibitors were further detected to explore the effect on melanoma cells growth and discovered a novel chalcone derivative Lj-1-60 that exhibited low cellular toxicity and high anti-tumor efficacy.	Chalcone	266-274	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
31609430-6	2020	Furthermore, Nyap1 regulated neuronal migration as a downstream target of Fyn, a nonreceptor protein-tyrosine kinase that is a member of the Src family of kinases.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
31609430-6	2020	Furthermore, Nyap1 regulated neuronal migration as a downstream target of Fyn, a nonreceptor protein-tyrosine kinase that is a member of the Src family of kinases.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
30963942-7	2020	The binding of quercetin disrupted the intra-molecular contacts making the SFK compact except Src kinase.	Quercetin	15-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	75-78
30963942-9	2020	An experimental validation was carried out against the activated forms of Fyn, Lyn and Src kinases, the top three proteins which showed high preference for quercetin.	Quercetin	156-165	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
31953701-1	2020	Fyn is a member of the protein tyrosine kinase family and its overexpression is associated with various types of inflammation.	Tyrosine	31-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
32051399-0	2020	Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo.	saracatinib	42-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
32435367-4	2020	Herein, starting from the knowledge that kinases are implicated in GBM, we evaluated three in-house pyrazolo[3,4-d]pyrimidines active as Src, Fyn, and SGK1 kinase inhibitors against patient derived cell lines from either the invasive region or contrast-enhanced core of GBM.	pyrazolo(3,4-d)pyrimidine	100-126	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
31566019-8	2020	LBW men displayed markedly decreased myotube gene expression levels of the AMPK-repressing tyrosine kinase gene FYN and the histone deacetylase gene HDAC7.	Tyrosine	91-99	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
31566019-9	2020	Silencing of FYN and HDAC7 was associated with impaired myotube formation, which for HDAC7 reduced muscle glucose uptake.	Glucose	106-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
31526816-9	2019	Notably, WZ3146 inhibited the activity of Lyn and Fyn, but not Syk.	WZ3146	9-15	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
31526816-0	2019	WZ3146 inhibits mast cell Lyn and Fyn to reduce IgE-mediated allergic responses in vitro and in vivo.	WZ3146	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
31526816-11	2019	Taken together, in this study we show that the pyrimidine derivative, WZ3146, inhibits the IgE-mediated allergic response by inhibiting Lyn and Fyn Src-family kinases, which are initially activated by antigen stimulation in MCs.	pyrimidine	47-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	144-147
31526816-11	2019	Taken together, in this study we show that the pyrimidine derivative, WZ3146, inhibits the IgE-mediated allergic response by inhibiting Lyn and Fyn Src-family kinases, which are initially activated by antigen stimulation in MCs.	WZ3146	70-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	144-147
31324193-13	2019	Expression and phosphorylation of Akt and GSK-3beta were also decreased with an upregulation of Fyn expression after steroid treatment.	Steroids	117-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-99
31717348-10	2019	Auraptene inhibited the phosphorylation of Lyn-Fyn-Syk, phospholipase Cgamma2 (PLCgamma2), protein kinase C (PKC), Akt, and mitogen-activated protein kinases (MAPKs; extracellular-signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK1/2), but not p38 MAPK).	aurapten	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
31400706-0	2019	Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.	pyrazolo(3,4-d)pyrimidine	34-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
31400706-3	2019	We recently identified Si308 as a potent Fyn inhibitor, while preliminary data showed that it might also inhibit Lyn and Blk.	si308	23-28	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
31400706-6	2019	Compound 2h emerged as a new multitarget inhibitor of Lyn, Fyn and Blk endowed with remarkable antiproliferative effects on human B and T lymphoma cell lines.	Deuterium	9-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
31329216-2	2019	AZD0530 is an investigational kinase inhibitor specific for the Src family, including fyn, that has been repurposed for the treatment of Alzheimer disease.	saracatinib	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
31329216-2	2019	AZD0530 is an investigational kinase inhibitor specific for the Src family, including fyn, that has been repurposed for the treatment of Alzheimer disease.	saracatinib	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
30717456-0	2019	GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species.	Reactive Oxygen Species	132-155	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
30928630-9	2019	Mechanistically, CS2164-induced cytotoxicity was closely associated with inhibition of VEGFR2 and its downstream signaling cascades, including Src/Fyn/p38 and Erk/MEK.	chiauranib	17-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	147-150
30480803-9	2019	Finally, interaction networks in the normal prostate gland and cancer tissues further revealed that RTN4 maybe phosphorylated by MAPKAPK2 and FYN at tyrosine 591 and serine 107, respectively.	Tyrosine	149-157	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
30480803-9	2019	Finally, interaction networks in the normal prostate gland and cancer tissues further revealed that RTN4 maybe phosphorylated by MAPKAPK2 and FYN at tyrosine 591 and serine 107, respectively.	Serine	166-172	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
30824700-3	2019	Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn.	Tyrosine	66-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
30824700-3	2019	Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn.	Tyrosine	66-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107
30717456-6	2019	The analysis suggests FYN is the central driver/hub for the cardiovascular response to space radiation: the known oxidative stress induced immediately following radiation would only be transient and would upregulate FYN, which in turn would reduce reactive oxygen species (ROS) levels, protecting the cardiovascular system.	Reactive Oxygen Species	248-271	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
30717456-6	2019	The analysis suggests FYN is the central driver/hub for the cardiovascular response to space radiation: the known oxidative stress induced immediately following radiation would only be transient and would upregulate FYN, which in turn would reduce reactive oxygen species (ROS) levels, protecting the cardiovascular system.	Reactive Oxygen Species	248-271	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	216-219
30717456-6	2019	The analysis suggests FYN is the central driver/hub for the cardiovascular response to space radiation: the known oxidative stress induced immediately following radiation would only be transient and would upregulate FYN, which in turn would reduce reactive oxygen species (ROS) levels, protecting the cardiovascular system.	Reactive Oxygen Species	273-276	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
30717456-6	2019	The analysis suggests FYN is the central driver/hub for the cardiovascular response to space radiation: the known oxidative stress induced immediately following radiation would only be transient and would upregulate FYN, which in turn would reduce reactive oxygen species (ROS) levels, protecting the cardiovascular system.	Reactive Oxygen Species	273-276	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	216-219
30266665-0	2018	miR-381 induces sensitivity of breast cancer cells to doxorubicin by inactivation of MAPK signaling via FYN.	Doxorubicin	54-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107
29747534-0	2018	Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors.	6-azacytosine	58-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
29747534-3	2018	In this study, starting from 3-(benzo[d][1,3]dioxol-5-ylamino)-6-methyl-1,2,4-triazin-5(2H)-one (VS6), a hit compound that showed a micromolar inhibition of Fyn (IC50 = 4.8 muM), we computationally investigated the binding interactions of the 3-amino-1,2,4-triazin-5(2H)-one scaffold and started a preliminary hit to lead optimisation.	3-(benzo[d][1,3]dioxol-5-ylamino)-6-methyl-1,2,4-triazin-5	29-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	157-160
30266665-8	2018	Additionally, FYN knockdown displayed similar effect on DOX sensitivity as miR-381 up-regulation.	Doxorubicin	56-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
30266665-9	2018	Furthermore, FYN overexpression partly reversed miR-381-induced sensitivity to DOX.	Doxorubicin	79-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
30266665-11	2018	In summary, miR-381 inactivated MAPK signaling by down-regulating FYN, thereby promoting the chemosensitization of breast cancer cells to DOX.	Doxorubicin	138-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
30266665-12	2018	Therefore, miR-381/FYN/MAPK pathway may be applied as a novel target to overcome DOX resistance in breast cancer patients.	Doxorubicin	81-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
29777684-6	2018	In in vitro protein kinase assay, AZD7762 inhibited the activity of Lyn and Fyn kinases, which are important for the activation of Syk in mast cells.	3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide	34-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
30400057-9	2018	Taken together, the endothelial protective effect of Baicalin under hyperglycemia condition could be partly attributed to its role in downregulating reactive oxygen species (ROS) and inflammation via the Akt/GSK3B/Fyn-mediated Nrf2 activation.	baicalin	53-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
30400057-9	2018	Taken together, the endothelial protective effect of Baicalin under hyperglycemia condition could be partly attributed to its role in downregulating reactive oxygen species (ROS) and inflammation via the Akt/GSK3B/Fyn-mediated Nrf2 activation.	Reactive Oxygen Species	149-172	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
29990840-12	2018	Furthermore, overexpression of Fyn could partially reverse the effects of miR-125a-3p on chemosensitivity to gemcitabine.	gemcitabine	109-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
30242243-0	2018	Correction: Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.	Tamoxifen	81-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
29777684-0	2018	Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn.	3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide	45-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-171
29066500-7	2017	In PTPN23-depleted tumors, we detected hyperphosphorylation of the autophosphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-catenin.	Tyrosine	92-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	132-135
29498447-3	2018	In this work, we investigate at the atomic level how three ATP-independent chaperones interact with a beta-sheet-rich protein, the Fyn SH3 domain.	Adenosine Triphosphate	59-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
29453318-8	2018	This bifurcation of signaling complexes from distinct ShcA pools transduces non-redundant signals that integrate the AKT/mTOR and SFK pathways to cooperatively increase breast tumor growth and resistance to tyrosine kinase inhibitors, including lapatinib and PP2.	Lapatinib	245-254	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
29790812-5	2018	Site-directed mutagenesis analysis identified two tyrosine residues (Y1470 and Y1471) located within the Nav1.7 DIII-DIV linker (L3) as phosphorylation sites of Fyn.	Tyrosine	50-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-164
29734505-4	2018	By co-immunoprecipitation and anti-phosphotyrosine blotting, we identified proline-rich binding sites for Fyn kinase in the N-terminal, IC-loopi-ii and C-terminal.	Phosphotyrosine	35-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
29734505-4	2018	By co-immunoprecipitation and anti-phosphotyrosine blotting, we identified proline-rich binding sites for Fyn kinase in the N-terminal, IC-loopi-ii and C-terminal.	Proline	75-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
29734505-5	2018	After binding, Fyn kinase phosphorylates tyrosine residues present in the N- and C-terminal, which produce a depolarizing shift of 7 mV in fast inactivation.	Tyrosine	41-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
29734505-7	2018	An activation and inactivation curves were recorded with or without co-expressed Fyn kinase which indicates that phosphorylation of tyrosine residues at positions 68, 87, 112 in the N-terminal and at positions 1811 and 1889 in the C-terminal creates a depolarizing shift in fast inactivation of NaV 1.5 channel.	Tyrosine	132-140	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
29470443-7	2018	Moreover, TQ-3 significantly abolished collagen-induced Lyn-Fyn-Syk, Akt-JNK and p38 mitogen-activated protein kinases (p38 MAPKs) phosphorylation.	tq-3	10-14	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
29390798-8	2018	Most importantly, we have quantified enhanced restriction in water dynamics around the second Fyn-binding site of the SAP due to SAP-SLAM complexation, even prior to the presence of Fyn.	Water	61-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	77-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
29390798-9	2018	This observation leads to a novel argument that SLAM induced more restricted water molecules could offer more water entropic contribution during the subsequent Fyn binding and provide enhanced stability to the SAP-Fyn complex in the signaling cascade.	Water	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
28948209-6	2017	Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	7-10
28888102-7	2017	The FYN inhibitor KX2-391 cooperated with dasatinib to block K562 RES proliferation.	kx2-391	18-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
28888102-7	2017	The FYN inhibitor KX2-391 cooperated with dasatinib to block K562 RES proliferation.	Dasatinib	42-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
28888102-7	2017	The FYN inhibitor KX2-391 cooperated with dasatinib to block K562 RES proliferation.	5-Bromoisatin	61-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
28811476-4	2017	By contrast, Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling.	Serine	52-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
28542923-6	2017	Idarubicin and irinotecan stimulate neurite outgrowth and survival of cultured cerebellar neurons after oxidative stress via protein kinase C and Erk1/2 in a similar manner as colominic acid, whereas Fyn, casein kinase II and the phosphatase and tensin homolog are only involved in idarubicin and irinotecan-stimulated neurite outgrowth.	Irinotecan	15-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	200-203
28380689-0	2017	Docking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP)-Insights into a noncanonical and fuzzy interaction.	Phospholipids	79-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
28380689-4	2017	In the membrane context, the xalpha2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the beta-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip.	Proline	87-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
28380689-4	2017	In the membrane context, the xalpha2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the beta-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip.	Proline	175-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
28424976-4	2017	The current study demonstrated that MG132-inhibited proteasome activity resulted in a dose dependence of CREB dephosphorylation at Ser133 as well as decreased phosphorylation of N-methyl-D-aspartate (NMDA) receptor subunit NR2B (Tyr1472) and its tyrosine protein kinase Fyn (Tyr416).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	36-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	270-273
28948209-7	2017	In cerebellar neurons and transfected HEK293T cells, the Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and acts to facilitate the surface expression of mGluR1a and to potentiate the mGluR1a postreceptor signaling.	Tyrosine	70-78	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
27926612-9	2017	Taken together, these results suggest that the tocotrienol analogue could inhibit the survival of PC3 cells under hypoxia, mainly by the inhibition of Fyn/HIF-1alpha signaling, and this may lead to the establishment of a new effective therapy for androgen-independent PCa.	Tocotrienols	47-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	151-154
28368000-5	2017	Inhibition of SFK activity not only alters TLR-ligand localization and inhibits downstream signalling events, but, independent of ex-vivo TLR stimulation, also affects constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways.	PAB-CAP protocol	200-204	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
28076826-4	2017	Enzymatic assays against a mini-panel of kinases (Src, Fyn, EGFR, Kit, Flt3, Abl, AblT315I) have been performed, showing an unexpected selectivity of our pyrrolo[2,3-d]pyrimidines for Src.	Pyrrolo(2,3-d)pyrimidine	154-179	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
27940153-11	2017	CONCLUSIONS AND GENERAL SIGNIFICANCE: Our findings suggest that Fyn kinase is part of a complex mechanism that regulates protein synthesis and OXPHOS possibly by tyrosine phosphorylation of translation components in mammalian mitochondria.	Tyrosine	162-170	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
28156097-1	2017	The interaction of two folding intermediate mimetics of the model protein substrate Fyn SH3 with the chaperonin GroEL, a supramolecular foldase/unfoldase machine, has been investigated by 15N relaxation-based nuclear magnetic resonance spectroscopy (lifetime line broadening, dark state exchange saturation transfer, and relaxation dispersion).	15n	188-191	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
26758454-9	2017	When the neutralizing antibody against NR2B p-Ser1303 was added into the medium, both the activations of Fyn and NR2B p-Tyr1472 were blocked, suggesting NR2B p-Ser1303 may be the initial step of NMDA-induced excitotoxicity.	N-Methylaspartate	195-199	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
26758454-7	2017	In order to explore whether there is a positive feedback way for post-synaptic NMDARs and the different pathway caused by 150 muM NMDA, the phosphorylation level of Fyn and the phosphorylation site of NR2B were investigated.	N-Methylaspartate	79-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	165-168
27733622-5	2016	Unexpectedly, Src-S3C/S6C (containing cysteines at positions 3/6, which are palmitoylated in Fyn) exhibited fast cytoplasmic diffusion insensitive to palmitoylation inhibitors, suggesting defective fatty acylation.	Cysteine	38-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
26758454-8	2017	It was observed that NR2B p-Tyr1472 was increased by the activation of Fyn after 150-muM NMDA exposure.	N-Methylaspartate	89-93	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	71-74
27733622-6	2016	Further replacement of the charged Lys-5 by neutral Gln to resemble Fyn (Src-S3C/S6C/K5Q) restored Fyn-like membrane interactions, indicating that Lys-5 in the context of Src-S3C/S6C interferes with its myristoylation/palmitoylation.	Glutamine	52-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	46-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	219-222
27626315-0	2016	Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy.	Adenosine Monophosphate	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
27626315-4	2016	Here we identified that Fyn phosphorylates the alpha subunit of AMPK on Y436 and inhibits AMPK enzymatic activity without altering the assembly state of the AMPK heterotrimeric complex.	y436	72-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
27626315-5	2016	As pro-inflammatory mediators are reported modulators of the autophagy processes, treatment with the pro-inflammatory cytokine TNFalpha resulted in 1) increased Fyn activity 2) stimulated Fyn-dependent AMPKalpha tyrosine phosphorylation and 3) decreased AICAR-dependent AMPK activation.	Tyrosine	212-220	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
27520374-10	2016	The phosphorylation level of tau at Tyr 18 was decreased in the si-Fyn group compared with the negative control group, but the inhibitory effect of si-Fyn on tau phosphorylation was attenuated when miR-106b expression was inhibited.	Tyrosine	36-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
27566560-0	2016	A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia.	pyrazolo(3,4-d)pyrimidine	2-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
27566560-4	2016	Our previous studies led us to identify 4c pyrazolo[3,4-d]pyrimidine compound capable of inhibiting Fyn activation and inducing apoptosis in different cancer cell lines.	4c pyrazolo[3,4-d]pyrimidine	40-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
27566560-10	2016	Moreover, we proved that Fyn inhibitor pyrazolo[3,4-d]pyrimidine compound, could be a started point to develop new therapeutic agents.	pyrazolo(3,4-d)pyrimidine	39-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
27525436-8	2016	Furthermore, FYN expression was markedly decreased in failing human hearts, corroborating its role as a regulator of cardiac cell death and ROS production.	ros	140-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
27420046-4	2016	In vitro, Fyn could be S-nitrosylated by S-nitrosoglutathione (GSNO, an exogenous NO donor), and in vivo, endogenous NO synthesized by NO synthases (NOS) could enhance Fyn S-nitrosylation.	S-Nitrosoglutathione	41-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
27420046-4	2016	In vitro, Fyn could be S-nitrosylated by S-nitrosoglutathione (GSNO, an exogenous NO donor), and in vivo, endogenous NO synthesized by NO synthases (NOS) could enhance Fyn S-nitrosylation.	S-Nitrosoglutathione	63-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
27420046-5	2016	Application of GSNO, 7-nitroindazole (7-NI, an inhibitor of neuronal NOS) and hydrogen maleate (MK-801, the N-methyl-d-aspartate receptor (NMDAR) antagonist) could decrease the S-nitrosylation and phosphorylation of Fyn induced by cerebral ischemia/reperfusion (I/R).	7-nitroindazole	21-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	216-219
27420046-5	2016	Application of GSNO, 7-nitroindazole (7-NI, an inhibitor of neuronal NOS) and hydrogen maleate (MK-801, the N-methyl-d-aspartate receptor (NMDAR) antagonist) could decrease the S-nitrosylation and phosphorylation of Fyn induced by cerebral ischemia/reperfusion (I/R).	Dizocilpine Maleate	96-102	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	216-219
27083550-6	2016	Fyn kinase auto phosphorylates in response to increased reactive oxygen species and directs the ubiquitin ligase c-Cbl to tag growth factor receptors for ubiquitination, potentially abrogating constitutively active survival pathways that are hallmarks of cancer progression.	Reactive Oxygen Species	56-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
27193083-8	2016	Here we report the identification of critical proline residues, Pro213, Pro216, and Pro219, located within the fifth and sixth Pro-X-X-Pro motifs in the proline-rich region of tau, that are important for its binding to fyn.	Proline	153-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	219-222
26455550-3	2015	Most importantly, myricetin interacts with oncoproteins such as protein kinase B (PKB) (Akt), Fyn, MEK1, and JAK1-STAT3 (Janus kinase-signal transducer and activator of transcription 3), and it attenuates the neoplastic transformation of cancer cells.	myricetin	18-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
26786295-6	2016	Furthermore, the KLF5/FYN/p-FAK axis is necessary for lysophosphatidic acid (LPA) to promote cell migration.	lysophosphatidic acid	54-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
26786295-6	2016	Furthermore, the KLF5/FYN/p-FAK axis is necessary for lysophosphatidic acid (LPA) to promote cell migration.	lysophosphatidic acid	77-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
26514807-4	2015	Herein, the synthesis of new 4-aminoimidazole and 2-aminothiazole derivatives and their in vitro biological evaluation are described for their potential use as SFK inhibitors.	4-aminoimidazole	29-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
26514807-4	2015	Herein, the synthesis of new 4-aminoimidazole and 2-aminothiazole derivatives and their in vitro biological evaluation are described for their potential use as SFK inhibitors.	2-aminothiazole	50-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
26514807-5	2015	Initially, 2-aminothiazole analogues of dasatinib and 4-aminoimidazole derivatives were synthesized and tested against the SFKs Src, Fyn, Lyn, and Yes.	2-aminothiazole	11-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	133-136
26365631-8	2016	Furthermore, Fyn accelerates the M phase progression of cells from nocodazole arrest.	Nocodazole	67-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
26767949-0	2016	PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3beta/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin.	Acetaminophen	95-108	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
26767949-5	2016	APAP subsided Nrf2 nuclear accumulation by activating Gsk3beta which phosphorylates Fyn kinase.	Acetaminophen	0-4	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
26767949-6	2016	p-Fyn kinase translocates into the nucleus and phosphorylates Nrf2 (Tyr 568) leading to its nuclear export, ubiquitination and degradation.	Tyrosine	68-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	2-5
26767949-10	2016	Morin, as a potent Nrf2 inducer accorded protection against acetaminophen induced renal damages by its molecular intervention with Akt-1/Gsk3beta/Fyn kinase pathway via PHLPP2 de-activation.	Acetaminophen	60-73	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	146-149
26493492-2	2016	Saracatinib potently inhibits Fyn activation.	saracatinib	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
26881253-0	2016	Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.	Glucose	18-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
26881253-2	2016	Recent studies have demonstrated that Fyn is responsible for nephrin tyrosine phosphorylation, which will result in polymerization of actin filaments and podocyte damage.	Tyrosine	69-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
26881253-5	2016	Our results presented that high glucose led to filamentous actin (F-actin) rearrangement in podocytes, accompanied by paxillin phosphorylation and increased cell motility, during which Fyn and ROCK were markedly activated.	Glucose	32-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	185-188
26881253-6	2016	Gene knockdown of Fyn by siRNA showed a reversal effect on high glucose-induced podocyte damage and ROCK activation; however, inhibition of ROCK had no significant effects on Fyn phosphorylation.	Glucose	64-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
26881253-7	2016	These observations demonstrate that in vitro Fyn mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation.	Glucose	63-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
26514807-5	2015	Initially, 2-aminothiazole analogues of dasatinib and 4-aminoimidazole derivatives were synthesized and tested against the SFKs Src, Fyn, Lyn, and Yes.	4-aminoimidazole	54-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	133-136
24976598-6	2015	Fyn inhibition with siRNA or Dasatinib also induced F-actin in MDA-MB-231 breast cancer cells, which have elevated Fyn.	Dasatinib	29-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
26140983-3	2015	Flavonoids attenuate activities of kinases including phosphoinositide-3-kinase, Fyn, Lyn, Src, Syk, PKC, PIM1/2, ERK, JNK and PKA.	Flavonoids	0-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Flavonoids	12-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
24976598-5	2015	Inhibition of Fyn activity, using siRNA or the clinical SFK inhibitor Dasatinib, increased cell-cell adhesion and rapidly (5-60 min) increased levels of cortical F-actin.	Dasatinib	70-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
26140983-6	2015	We examined flavonoid (quercetin, apigenin and catechin) interactions with Src family kinases (Lyn, Fyn and Hck) applying the Sybyl docking algorithm and GRID.	Catechin	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
24976598-11	2015	Together these results identify the promotion of actin-based cell-cell adhesion as a newly described mechanism of action for Dasatinib and suggest that Fyn inhibition may be an effective therapeutic approach in treating cSCC.	Dasatinib	125-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
26305432-5	2015	We have recently shown that Fyn is upregulated in tamoxifen-resistant breast cancer cell lines and demonstrated that it plays a key role in the resistance mechanism.	Tamoxifen	50-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
26334723-4	2015	Under basal conditions, DHHC5 is bound to PSD-95 and Fyn kinase, and is stabilized at the synaptic membrane through Fyn-mediated phosphorylation of a tyrosine residue within the endocytic motif of DHHC5.	Tyrosine	150-158	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
26229100-3	2015	In this study we identified a tyrosine site on the GluN2B subunit, Tyr-1070, which was phosphorylated by a proto-oncogene tyrosine-protein (Fyn) kinase and critical for the surface expression of GluN2B-containing NMDARs.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
26229100-3	2015	In this study we identified a tyrosine site on the GluN2B subunit, Tyr-1070, which was phosphorylated by a proto-oncogene tyrosine-protein (Fyn) kinase and critical for the surface expression of GluN2B-containing NMDARs.	Tyrosine	67-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
26229100-4	2015	The phosphorylation of GluN2B at Tyr-1070 was required for binding of Fyn kinase to GluN2B, which up-regulated the phosphorylation of GluN2B at Tyr-1472.	Tyrosine	33-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
26229100-4	2015	The phosphorylation of GluN2B at Tyr-1070 was required for binding of Fyn kinase to GluN2B, which up-regulated the phosphorylation of GluN2B at Tyr-1472.	Tyrosine	144-147	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
26229100-5	2015	Moreover, our results revealed that the phosphorylation change of GluN2B at Tyr-1070 accompanied the Tyr-1472 phosphorylation and Fyn associated with GluN2B in synaptic plasticity induced by both chemical and contextual fear learning.	Tyrosine	76-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
26136341-6	2015	Knockdown studies revealed that p47phox modulated reactive oxygen species and Egr-1 expression, which, in turn, controlled Fyn expression.	Reactive Oxygen Species	50-73	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	123-126
26136341-7	2015	Interestingly, Fyn knockdown sensitized TKI-resistant cells to dasatinib, a dual BCR-ABL1/Src inhibitor.	Dasatinib	63-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
25155877-6	2015	At the molecular levels, under glutathione-deficit conditions induced by short hairpin RNA targeting the key glutathione synthesis enzyme, oligodendrocyte progenitors showed a decreased proliferation mediated by an upregulation of Fyn kinase activity, reversed by either the antioxidant N-acetylcysteine or Fyn kinase inhibitors.	Glutathione	31-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
26407913-1	2015	The tyrosine kinase Fyn phosphorylates tyrosine residues on key targets involved in early T-cell signal transduction.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
26407913-6	2015	The Fyn -93G allele exhibits in healthy controls a statistically significant lower frequency than in liver recipients (18% vs. 24%; p=0.046) or in liver recipients with BPAR (18% vs. 27%; p=0.017).	bpar	169-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
26099359-5	2015	After incubation with BzATP, the activity of Fyn, one member of the Src family of kinases, was enhanced.	BzATP	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
26099359-5	2015	After incubation with BzATP, the activity of Fyn, one member of the Src family of kinases, was enhanced.	BzATP	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
26099359-7	2015	After blocking the activity of Fyn or down-regulating the expression of Fyn, the migration of OPCs induced by BzATP was inhibited.	BzATP	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
26099359-7	2015	After blocking the activity of Fyn or down-regulating the expression of Fyn, the migration of OPCs induced by BzATP was inhibited.	BzATP	110-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
26099359-8	2015	These data indicate that P2X7 receptors/Fyn may mediate ATP-induced OPC migration under pathological conditions.	Adenosine Triphosphate	56-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
26099359-0	2015	P2X7 receptors and Fyn kinase mediate ATP-induced oligodendrocyte progenitor cell migration.	Adenosine Triphosphate	38-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
26379499-10	2015	Ago2 associates with hnRNP A2, Mbp mRNA, sncRNA715 and Fyn kinase and is tyrosine phosphorylated in response to Fyn activity.	Tyrosine	73-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
25951993-1	2015	The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
25951993-1	2015	The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
25951993-1	2015	The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity.	Tyrosine	103-106	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
25951993-1	2015	The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity.	Tyrosine	125-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
25951993-1	2015	The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity.	Tyrosine	125-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
25951993-2	2015	Within the central nervous system, two protein tyrosine phosphatases (PTPs) target these regulatory tyrosines in Fyn.	Tyrosine	100-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
25951993-6	2015	Dephosphorylation of Tyr(789) prevents the translocation of PTPalpha to synaptic membranes, blocking its ability to interact with and activate Fyn.	Tyrosine	21-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
25951993-8	2015	Activation of PTPalpha and Fyn and trafficking of GluN2B to synaptic membranes are necessary for ethanol (EtOH) intake behaviors in rodents.	Ethanol	97-104	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
25951993-8	2015	Activation of PTPalpha and Fyn and trafficking of GluN2B to synaptic membranes are necessary for ethanol (EtOH) intake behaviors in rodents.	Ethanol	106-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
25951993-9	2015	We tested the functional significance of STEP61 in this signaling pathway by EtOH administration to primary cultures as well as in vivo, and demonstrated that the inactivation of STEP61 by EtOH leads to the activation of PTPalpha, its translocation to synaptic membranes, and the activation of Fyn.	Ethanol	189-193	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	294-297
25951993-11	2015	STEP61 , PTPalpha, Fyn, and NMDA receptor (NMDAR) have been implicated in ethanol intake behaviors in the dorsomedial striatum (DMS) in rodents.	Ethanol	74-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
25951993-15	2015	The results demonstrate a synergistic regulation of Fyn-NMDAR signaling by STEP61 and PTPalpha, which may contribute to the regulation of ethanol-related behaviors.	Ethanol	138-145	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
25155877-6	2015	At the molecular levels, under glutathione-deficit conditions induced by short hairpin RNA targeting the key glutathione synthesis enzyme, oligodendrocyte progenitors showed a decreased proliferation mediated by an upregulation of Fyn kinase activity, reversed by either the antioxidant N-acetylcysteine or Fyn kinase inhibitors.	Glutathione	31-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	307-310
25155877-6	2015	At the molecular levels, under glutathione-deficit conditions induced by short hairpin RNA targeting the key glutathione synthesis enzyme, oligodendrocyte progenitors showed a decreased proliferation mediated by an upregulation of Fyn kinase activity, reversed by either the antioxidant N-acetylcysteine or Fyn kinase inhibitors.	Glutathione	109-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
25155877-6	2015	At the molecular levels, under glutathione-deficit conditions induced by short hairpin RNA targeting the key glutathione synthesis enzyme, oligodendrocyte progenitors showed a decreased proliferation mediated by an upregulation of Fyn kinase activity, reversed by either the antioxidant N-acetylcysteine or Fyn kinase inhibitors.	Acetylcysteine	287-303	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
25155877-8	2015	Interestingly, the regulation of Fyn mRNA and protein expression was also impaired in fibroblasts of patients deficient in glutathione synthesis.	Glutathione	123-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
26125726-0	2015	Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation.	Swainsonine	12-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
25874001-5	2015	Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treatment of patients with mild-to-moderate AD.	saracatinib	75-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
25770215-5	2015	Tyrosine phosphorylation of AKAP8 is induced by several tyrosine kinases, such as Src, Fyn, and c-Abl but not Syk.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
25874001-5	2015	Herein, we present a Phase Ib trial of the repurposed investigational drug AZD0530, a Src family kinase inhibitor specific for Fyn and Src kinase, for the treatment of patients with mild-to-moderate AD.	saracatinib	75-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	127-130
26382759-7	2015	The enzymatic activity of Fyn kinase and phosphorylation of Nav1.5 channel were ascertained by immunoprecipitation and anti-phosphotyrosine immunoblotting.	Phosphotyrosine	124-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-29
24882577-0	2015	Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.	Tamoxifen	69-78	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
24882577-4	2015	Moreover, overexpression of FYN in parental tamoxifen-sensitive MCF-7/S0.5 cells resulted in reduced sensitivity to tamoxifen treatment, whereas knockdown of FYN in the FYN-overexpressing MCF-7/S0.5 cells restored sensitivity to tamoxifen, demonstrating growth- and survival-promoting function of FYN in MCF-7 cells.	Tamoxifen	44-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
24882577-4	2015	Moreover, overexpression of FYN in parental tamoxifen-sensitive MCF-7/S0.5 cells resulted in reduced sensitivity to tamoxifen treatment, whereas knockdown of FYN in the FYN-overexpressing MCF-7/S0.5 cells restored sensitivity to tamoxifen, demonstrating growth- and survival-promoting function of FYN in MCF-7 cells.	Tamoxifen	116-125	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
24882577-4	2015	Moreover, overexpression of FYN in parental tamoxifen-sensitive MCF-7/S0.5 cells resulted in reduced sensitivity to tamoxifen treatment, whereas knockdown of FYN in the FYN-overexpressing MCF-7/S0.5 cells restored sensitivity to tamoxifen, demonstrating growth- and survival-promoting function of FYN in MCF-7 cells.	Tamoxifen	116-125	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
24882577-5	2015	FYN knockdown in TamR cells led to reduced phosphorylation of 14-3-3 and Cdc25A, suggesting that FYN, by activation of important cell cycle-associated proteins, may overcome the anti-proliferative effects of tamoxifen.	Tamoxifen	208-217	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
24882577-5	2015	FYN knockdown in TamR cells led to reduced phosphorylation of 14-3-3 and Cdc25A, suggesting that FYN, by activation of important cell cycle-associated proteins, may overcome the anti-proliferative effects of tamoxifen.	Tamoxifen	208-217	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	97-100
24882577-8	2015	Our results indicate that FYN has an important role in tamoxifen resistance, and its subcellular localization in breast tumor cells may be an important novel biomarker of response to endocrine therapy in breast cancer.	Tamoxifen	55-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-29
26646899-7	2015	The associations between the methylation of selected DMCpGs with childhood obesity were validated using sodium bisulfite pyrosequencing across loci within the FYN, PIWIL4, and TAOK3 genes in individual subjects.	dmcpgs	53-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	159-162
24819299-6	2014	Knockdown of c-Src, Yes or treatment with the SFK inhibitor dasatinib inhibited the migration of GSCs, but had no impact on their growth or self-renewal.	Dasatinib	60-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
25316710-7	2015	In addition, N-terminal tyrosine sites of SLP-76 also perturbed phosphorylation of Tyr(440) of Fyn, Tyr(702) of PLCgamma1, Tyr(204), Tyr(397), and Tyr(69) of ZAP-70, revealing new modes of regulation on these sites.	Tyrosine	24-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
25316710-7	2015	In addition, N-terminal tyrosine sites of SLP-76 also perturbed phosphorylation of Tyr(440) of Fyn, Tyr(702) of PLCgamma1, Tyr(204), Tyr(397), and Tyr(69) of ZAP-70, revealing new modes of regulation on these sites.	Tyrosine	83-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
25340851-5	2014	Via a separate mechanism, ApoER2 is also phosphorylated by Fyn, an event that peaks in the postnatal cortex at day 5 and can occur at multiple ApoER2 tyrosine residues.	Tyrosine	150-158	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
25251774-0	2014	The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.	Aspartic Acid	4-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
25251774-7	2014	Our work provides in vivo and in vitro evidence that the aspartic acid of Fyn at 390 is indispensable for the radial migration, and it is required for precise cooperation with focal adhesion kinase.	Aspartic Acid	57-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
25118278-3	2014	Through insertion of a modified FK506 binding protein (insertable FKBP12, iFKBP) into the protein kinase isoforms Fyn, Src, Lyn, and Yes, we engineered kinase analogs that can be activated within minutes in living cells (RapR analogs).	Tacrolimus	32-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
24610809-0	2014	YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet beta cells.	Glucose	40-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	7-10
24970799-4	2014	We report that FYN phosphorylates human COX2 on Tyr 446, and while corresponding phospho-mimetic COX2 mutation promotes COX2 activity, the phosphorylation blocking mutation prevents FYN-mediated increase in COX2 activity.	Tyrosine	48-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
24610809-4	2014	Toward this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK inhibitors to block glucose-stimulated Cdc42 and PAK1 activation events as well as the amplifying pathway of glucose-stimulated insulin release, in MIN6 beta cells.	Glucose	216-223	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
24515388-7	2014	Dex significantly resisted podocyte injury inducted by AngII via increasing the phosphorylation of nephrin (P < 0.05), siRNA silencing Nck can partially inhibited nephrin phosphorylation, siRNA silencing Fyn can completely inhibited nephrin phosphorylation.	Dexamethasone	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	207-210
24627473-3	2014	We determined that both mouse and human IFITM3 are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr(20)) and that mouse IFITM3 is also phosphorylated on the non-conserved Tyr(27).	Tyrosine	81-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	97-100
24627473-3	2014	We determined that both mouse and human IFITM3 are phosphorylated by the protein-tyrosine kinase FYN on tyrosine 20 (Tyr(20)) and that mouse IFITM3 is also phosphorylated on the non-conserved Tyr(27).	Tyrosine	117-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	97-100
24610809-5	2014	Indeed, subsequent studies performed in human islets revealed that SFK phosphorylation was induced only by glucose and within 1 min of stimulation before the activation of Cdc42 at 3 min.	Glucose	107-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
24610809-4	2014	Toward this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK inhibitors to block glucose-stimulated Cdc42 and PAK1 activation events as well as the amplifying pathway of glucose-stimulated insulin release, in MIN6 beta cells.	Glucose	127-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
24610809-7	2014	Although RT-PCR showed beta cells to express five different SFK proteins, only two of these, YES and Fyn kinases, were found localized to the plasma membrane, and of these two, only YES kinase underwent glucose-stimulated tyrosine phosphorylation.	Glucose	203-210	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
24586768-6	2014	Purification and mass-spectrometric analysis of tyrosine-phosphorylated proteins in response to overexpressed active Fyn in the oligodendrocyte precursor cell line Oli-neu, yielded the adaptor molecule p130Cas.	Tyrosine	48-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	117-120
24610809-7	2014	Although RT-PCR showed beta cells to express five different SFK proteins, only two of these, YES and Fyn kinases, were found localized to the plasma membrane, and of these two, only YES kinase underwent glucose-stimulated tyrosine phosphorylation.	Glucose	203-210	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
24001328-4	2013	By the application of the best procedure, the virtual screening workflow was used to filter the Gold and Platinum database from Asinex to identify new Fyn inhibitors.	Platinum	105-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	151-154
24495408-5	2014	We are currently enrolling patients in a phase Ib study of saracatinib (AZD0530), a small molecule inhibitor with high potency for Src and Fyn, for the treatment of AD.	saracatinib	59-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
24495408-5	2014	We are currently enrolling patients in a phase Ib study of saracatinib (AZD0530), a small molecule inhibitor with high potency for Src and Fyn, for the treatment of AD.	saracatinib	72-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
24489884-7	2014	CONCLUSIONS: Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density.	Inositol 1,4,5-Trisphosphate	51-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
24489884-7	2014	CONCLUSIONS: Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density.	Inositol 1,4,5-Trisphosphate	81-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
24489884-7	2014	CONCLUSIONS: Fyn interacts with NDMA receptors and inositol-1,4,5-trisphosphate (IP3)-gated channels to regulate calcium influx and intracellular release in the post-synaptic density.	Calcium	113-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
23716303-7	2013	Inhibition of FYN and FAK phosphorylation each increased tumor cell sensitivity to imatinib.	Imatinib Mesylate	83-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
23716303-9	2013	These results indicate that FYN or FAK might be potential therapeutic targets to overcome resistance to imatinib in GISTs.	Imatinib Mesylate	104-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
22957720-1	2013	In this study, the synthesis and potential enzyme interactions of new Pyrrolo[2,3-d]pyrimidine derivatives along with their inhibitory activity against SFK enzymes such as Fyn, Lyn, Hck, and c-Src were reported.	Pyrrolo(2,3-d)pyrimidine	70-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
23836527-6	2013	Activation of mTORC2 was further diminished following FAK inhibition, and as FAK phosphorylation (Tyr-397) required Fyn activity, provided evidence of Fyn/FAK cooperativity.	Tyrosine	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
23836527-6	2013	Activation of mTORC2 was further diminished following FAK inhibition, and as FAK phosphorylation (Tyr-397) required Fyn activity, provided evidence of Fyn/FAK cooperativity.	Tyrosine	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	151-154
24003228-7	2013	Stimulation of VSM cells with ionomycin, a calcium ionophore, resulted in activation of CaMKIIdelta2 and Fyn and disruption of the complex.	Ionomycin	30-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
24003228-7	2013	Stimulation of VSM cells with ionomycin, a calcium ionophore, resulted in activation of CaMKIIdelta2 and Fyn and disruption of the complex.	Calcium	43-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
24003228-8	2013	Pretreatment with KN-93, a pharmacological inhibitor of CaMKII, prevented activation-dependent disruption of CaMKIIdelta2 and Fyn, implicating CaMKIIdelta2 as an upstream mediator of Fyn.	KN 93	18-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	126-129
24003228-8	2013	Pretreatment with KN-93, a pharmacological inhibitor of CaMKII, prevented activation-dependent disruption of CaMKIIdelta2 and Fyn, implicating CaMKIIdelta2 as an upstream mediator of Fyn.	KN 93	18-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
24003228-9	2013	Overexpression of constitutively active CaMKII resulted in the dephosphorylation of Fyn at Tyr-527, which is required for Fyn activation.	Tyrosine	91-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
24003228-9	2013	Overexpression of constitutively active CaMKII resulted in the dephosphorylation of Fyn at Tyr-527, which is required for Fyn activation.	Tyrosine	91-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
22957720-1	2013	In this study, the synthesis and potential enzyme interactions of new Pyrrolo[2,3-d]pyrimidine derivatives along with their inhibitory activity against SFK enzymes such as Fyn, Lyn, Hck, and c-Src were reported.	Pyrrolo(2,3-d)pyrimidine	70-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	172-175
22709448-0	2012	Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-beta peptide treatment.	Oxygen	66-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
23922104-11	2013	CONCLUSION: These results strongly indicate Src family kinases, in particular Fyn, as a potential target for the treatment of inoperable and metastatic chondrosarcomas, and to sensitise for doxorubicin especially in the presence of TP53 mutations.	Doxorubicin	190-201	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	78-81
23746236-7	2013	Compared with other groups, the quantitative RT-PCR and Western blotting showed that the expression of CD59 was reduced, and along with it the phosphorylation level of fyn decreased in pSUPER-siCD59 group, and MTT assay revealed that its cell proliferation was inhibited (P<0.05).	monooxyethylene trimethylolpropane tristearate	210-213	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-171
25436571-1	2013	The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile acids.	Bile Acids and Salts	245-255	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
25436571-1	2013	The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile acids.	Bile Acids and Salts	245-255	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
25436571-5	2013	This review will discuss the role of Src family kinases in the regulation of liver function with emphasis on their role in osmo-signaling and bile acid signaling.	Bile Acids and Salts	142-151	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
22859831-8	2012	Collectively, the findings demonstrate that EP(2) suppresses the Fyn-mediated signals that are central to FcepsilonRI-dependent MC degranulation, suggesting that engagement of the EP(2) on MCs may be beneficial in dampening allergic responses.	Methylcholanthrene	128-130	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
23606532-0	2013	Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.	Tamoxifen	96-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
23334362-6	2013	shRNA-mediated knockdown of either ANXA2, FYN, LCK or S100A10, all led to inhibition of annexin A2 phosphorylation and resulted in marked sensitization to prednisolone.	Prednisolone	155-167	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
23334362-7	2013	Likewise, exposure of prednisolone-resistant MLL-rearranged ALL cells to different Src kinase inhibitors exerting high specificity towards FYN and/or LCK had similar effects.	Prednisolone	22-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
23131831-5	2012	First, the Src family protein tyrosine kinases (SF-PTKs), including Src, Fyn, Lyn, and Fgr, interact with and phosphorylate tyrosine residue 374 (Y374) of IKKgamma/NEMO.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
22924694-0	2012	Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling.	Ethanol	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
22924694-3	2012	We reported that ethanol inhibits the stimulation of axon outgrowth in cerebellar granule neurons (CGN) by NAP, an active motif of activity-dependent neuroprotective protein (ADNP), by blocking NAP activation of Fyn kinase and its downstream signaling molecule, the scaffolding protein Cas.	Ethanol	17-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	212-215
22924694-3	2012	We reported that ethanol inhibits the stimulation of axon outgrowth in cerebellar granule neurons (CGN) by NAP, an active motif of activity-dependent neuroprotective protein (ADNP), by blocking NAP activation of Fyn kinase and its downstream signaling molecule, the scaffolding protein Cas.	N-(4-aminophenethyl)spiroperidol	107-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	212-215
22777522-3	2012	We show that the hyperresponsive phenotype of B cells lacking Lyn is predicated on significantly increased basal and inducible PI3K activity that correlates with the constitutive hypophosphorylation of PAG/Cbp (phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk-binding protein), a concomitant reduction in bound Csk in Lyn(-/-) B cells and elevated levels of active Fyn.	phenylacetylglycine	202-205	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	391-394
22709448-2	2012	In this study, we investigated whether Src and Fyn kinases, two major members of SrcPTKs in the brain, have distinct roles in the oxygen and glucose deprivation (OGD) and amyloid-beta peptide (Abeta)-induced neuronal apoptosis.	Oxygen	130-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
22709448-3	2012	METHODS AND RESULTS: The DAPI staining and caspase-3 activation analysis showed that small interfering RNAs (siRNAs) knockdown of Src or Fyn attenuated SH-SY5Y cells apoptosis after OGD and Abeta treatment.	DAPI	25-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
22621321-4	2012	In addition, the concepts of proximity-driven catalysis are extended to include modification of the natural Fyn SH3 domain with metallopeptides based on a known proline-rich peptide ligand.	Proline	161-168	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
22771471-0	2012	Enhanced antioxidant effect of prenylated polyphenols as Fyn inhibitor.	Polyphenols	42-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
22771471-7	2012	In vitro or in a cell-based assay, tyrosine phosphorylation of Fyn was prohibited by kazinol E, which led to LKB1 activation, as shown by the experiments using Fyn over-expression construct or siRNA.	Tyrosine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
22771471-7	2012	In vitro or in a cell-based assay, tyrosine phosphorylation of Fyn was prohibited by kazinol E, which led to LKB1 activation, as shown by the experiments using Fyn over-expression construct or siRNA.	Tyrosine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
22771471-7	2012	In vitro or in a cell-based assay, tyrosine phosphorylation of Fyn was prohibited by kazinol E, which led to LKB1 activation, as shown by the experiments using Fyn over-expression construct or siRNA.	Kazinol E	85-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
22771471-7	2012	In vitro or in a cell-based assay, tyrosine phosphorylation of Fyn was prohibited by kazinol E, which led to LKB1 activation, as shown by the experiments using Fyn over-expression construct or siRNA.	Kazinol E	85-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
22771471-8	2012	SU6656, a known Fyn inhibitor, had a similar effect.	SU 6656	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
22771471-9	2012	Moreover, oxidative stress facilitated Fyn phosphorylation with repression of AMPKalpha and GSK3beta phosphorylation, which was abolished by kazinol E treatment.	Kazinol E	141-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
22771471-10	2012	The role of Fyn inhibition by kazinol E in AMPK-mediated protection of the cell viability and mitochondrial function was strengthened by ectopically expressed Fyn"s reversal of these effects.	Kazinol E	30-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	12-15
22771471-10	2012	The role of Fyn inhibition by kazinol E in AMPK-mediated protection of the cell viability and mitochondrial function was strengthened by ectopically expressed Fyn"s reversal of these effects.	Kazinol E	30-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	159-162
22771471-11	2012	In conclusion, kazinols as multi-prenylated polyphenols possess increased antioxidant and cytoprotective activity, which depends on the activation of LKB1-AMPK pathway downstream of Fyn inhibition.	kazinols	15-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	182-185
22771471-11	2012	In conclusion, kazinols as multi-prenylated polyphenols possess increased antioxidant and cytoprotective activity, which depends on the activation of LKB1-AMPK pathway downstream of Fyn inhibition.	Polyphenols	44-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	182-185
22474169-0	2012	Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury.	Cycloparaffins	18-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
22474169-0	2012	Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury.	1,2-dithiol-3-thione	36-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
22474169-3	2012	This study investigated the potential of a series of cycloalkane-fused dithiolethiones (CDTs) or other congeners to increase antioxidant capacity in association with Fyn inhibition, as well as the molecular basis for this effect.	cycloalkane-fused dithiolethiones	53-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	166-169
22474169-3	2012	This study investigated the potential of a series of cycloalkane-fused dithiolethiones (CDTs) or other congeners to increase antioxidant capacity in association with Fyn inhibition, as well as the molecular basis for this effect.	cdts	88-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	166-169
22474169-7	2012	Oxidative injury caused by arachidonic acid and iron enhanced Fyn phosphorylation at a tyrosine residue, which was decreased by SNU1A treatment.	Arachidonic Acid	27-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
22474169-7	2012	Oxidative injury caused by arachidonic acid and iron enhanced Fyn phosphorylation at a tyrosine residue, which was decreased by SNU1A treatment.	Iron	48-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
22474169-7	2012	Oxidative injury caused by arachidonic acid and iron enhanced Fyn phosphorylation at a tyrosine residue, which was decreased by SNU1A treatment.	Tyrosine	87-95	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
22474169-8	2012	2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide (SU6656), a known Fyn inhibitor, had a similar effect.	SU 6656	104-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
22474169-14	2012	Our results demonstrate that CDTs exert cytoprotective effects by protecting mitochondria and increasing the cellular antioxidant capacity, which may result not only from Fyn inhibition leading to AMPK activation but also from Nrf2 activation.	cdts	29-33	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	171-174
22868769-3	2012	The 1.5 A resolution crystal structure of a complex between the SH3 domain of the Fyn tyrosine kinase and the C-terminal proline-rich motif of the NS5A-derived peptide APPIPPPRRKR has been solved.	Proline	121-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
22868769-7	2012	The proline-rich motif present in the NS5A protein seems to be important for RNA replication and virus assembly, and the promiscuous interaction of the Fyn SH3 domain with the NS5A C-terminal proline-rich peptide found in this crystallographic structure may be important in the virus infection cycle.	Proline	4-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
22868769-7	2012	The proline-rich motif present in the NS5A protein seems to be important for RNA replication and virus assembly, and the promiscuous interaction of the Fyn SH3 domain with the NS5A C-terminal proline-rich peptide found in this crystallographic structure may be important in the virus infection cycle.	Proline	192-199	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
22634315-5	2012	FYN was knocked down in R-HepG2 cells, leading to less drug resistance by increased cell viability, increased doxorubicin uptake and attenuated P-glycoprotein expression.	Doxorubicin	110-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Lysine	50-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
22447928-7	2012	LPS increased binding of both c-Src and Fyn to GST-TRAF6 but not to a GST-TRAF6 mutant in which the three prolines in the putative Src homology 3 domain-binding motif (amino acids 461-469) were substituted with alanines.	Alanine	211-219	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Tyrosine	131-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
22447928-8	2012	A cell-permeable decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 compared with the Pro   Ala-substituted peptide.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
22447928-9	2012	Finally, LPS increased binding of activated Tyr(P)(416)-SFK to GST-TRAF6, and preincubation of HMVEC-Ls with SFK-selective tyrosine kinase inhibitors, PP2 and SU6656, diminished TRAF6 binding to c-Src and Fyn.	Tyrosine	44-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
22447928-10	2012	During the TRAF6-SFK association, TRAF6 catalyzed Lys(63)-linked ubiquitination of c-Src and Fyn, whereas SFK activation increased tyrosine phosphorylation of TRAF6.	Tyrosine	131-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
22447928-12	2012	Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF6 interacts directly with activated SFKs to couple LPS engagement of TLR4 to SFK activation and loss of barrier integrity in HMVEC-Ls.	Proline	39-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
21794954-4	2012	Here, we show that phosphorylation of tau at tyrosine 18, which is a fyn phosphorylation site within PAD, prevents inhibition of anterograde FAT induced by both filamentous tau and 6D tau.	Tyrosine	45-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
22403409-8	2012	Remarkably, the protein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and tau, inhibits the interaction of PP2A/Balpha with either tau or MAP2c.	Proline	64-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
22354875-10	2012	Dasatinib, an inhibitor of multi-tyrosine kinases including SFK, also inhibited SFK activity and induced reduction of Lyn protein levels, caspase-8 activation and apoptosis in NCI-H28 cells but not in other cell lines.	Dasatinib	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
22354875-10	2012	Dasatinib, an inhibitor of multi-tyrosine kinases including SFK, also inhibited SFK activity and induced reduction of Lyn protein levels, caspase-8 activation and apoptosis in NCI-H28 cells but not in other cell lines.	Dasatinib	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
21794954-5	2012	Moreover, Fyn-mediated phosphorylation of tyrosine 18 is reduced in disease-associated forms of tau (e.g., tau filaments).	Tyrosine	42-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
22442244-0	2012	Purification, crystallization and preliminary X-ray diffraction analysis of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	phosphotyrosine peptide	118-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
22442244-2	2012	The SH2 domain of the human protein tyrosine kinase Fyn has been expressed, purified and crystallized in the unbound state and in complex with a high-affinity phosphotyrosine peptide.	phosphotyrosine peptide	159-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
22139003-0	2012	Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin beta4 and Fyn.	sphingosine phosphorylcholine	40-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	155-158
21890592-3	2012	Some association with lithium prophylactic efficacy was found for the polymorphisms of 5HTT, DRD1, COMT, BDNF and FYN genes, but not for 5HT2A, 5HT2C, DRD2, DRD3, DRD4, GSK-3, NTRK2, GRIN2B and MMP-9.	Lithium	22-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
21951603-0	2012	Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.	sphingosine phosphorylcholine	0-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	191-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	191-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	191-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	214-217	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	214-217	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
21951603-7	2012	Constitutively active Fyn (ca-Fyn) stimulated stress fiber formation and localized with F-actin at the both ends of stress fibers, both of which were prevented by Fyn translocation inhibitor eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	214-217	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
23077515-12	2012	These results suggest that NS5A directly binds to the SH2 domain of Fyn in a tyrosine phosphorylation-dependent manner.	Tyrosine	77-85	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
21985328-5	2012	The NMDA receptor is a major target of ethanol in the brain, and accumulating evidence suggests that Fyn mediates the effects of ethanol by regulating the phosphorylation of GluN2B NMDA receptor subunits.	Ethanol	39-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
21985328-5	2012	The NMDA receptor is a major target of ethanol in the brain, and accumulating evidence suggests that Fyn mediates the effects of ethanol by regulating the phosphorylation of GluN2B NMDA receptor subunits.	Ethanol	129-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
21985328-6	2012	Furthermore, Fyn has been shown to regulate alcohol withdrawal and acute tolerance to ethanol through a GluN2B-dependent mechanism.	Alcohols	44-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
21985328-6	2012	Furthermore, Fyn has been shown to regulate alcohol withdrawal and acute tolerance to ethanol through a GluN2B-dependent mechanism.	Ethanol	86-93	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
23077515-13	2012	Lastly, we showed that the expression of NS5A in B cells increased phosphorylation of activation loop tyrosine in the kinase domain of Fyn.	Tyrosine	102-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
21792912-7	2011	Activation of a ~61 kDa SFK was evident from an increase in Y416 phosphorylation, which reached a maximum at 15 min ET-1 treatment, and a decrease in Y527 phosphorylation.	y416	60-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
21298565-0	2011	1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	Hydrogen	0-2	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
21298565-0	2011	1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	13c	4-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
21298565-0	2011	1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	15n	12-15	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
21298565-0	2011	1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.	phosphotyrosine peptide	111-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
21881001-4	2011	Cytoskeletal changes and phosphorylation events mediated by Fyn activity were reversed by TM4SF10 overexpression, including a decrease in the activating tyrosine phosphorylation of Fyn (Y(421)), suggesting TM4SF10 may have a regulatory role in suppressing Fyn activity.	Tyrosine	153-161	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
21881001-4	2011	Cytoskeletal changes and phosphorylation events mediated by Fyn activity were reversed by TM4SF10 overexpression, including a decrease in the activating tyrosine phosphorylation of Fyn (Y(421)), suggesting TM4SF10 may have a regulatory role in suppressing Fyn activity.	Tyrosine	153-161	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	181-184
21881001-4	2011	Cytoskeletal changes and phosphorylation events mediated by Fyn activity were reversed by TM4SF10 overexpression, including a decrease in the activating tyrosine phosphorylation of Fyn (Y(421)), suggesting TM4SF10 may have a regulatory role in suppressing Fyn activity.	Tyrosine	153-161	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	181-184
21813412-8	2011	The siRNA knockdown of Src, Fyn, or Abl1 enhanced paclitaxel-mediated growth inhibition in ovarian cancer cells compared with a control siRNA.	Paclitaxel	50-60	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
21670084-2	2011	Among the most sensitive dasatinib targets are ABL, the SRC family kinases (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), and the receptor tyrosine kinases c-KIT, platelet-derived growth factor receptor (PDGFR) alpha and beta, discoidin domain receptor 1 (DDR1), c-FMS, and ephrin receptors.	Dasatinib	25-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	91-94
21757751-5	2011	After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation.	Tyrosine	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
21757751-5	2011	After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation.	Tyrosine	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	176-179
21757751-5	2011	After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation.	Tyrosine	73-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
21757751-5	2011	After CD5 ligation, phosphorylation of the negative regulatory tyrosine (Tyr(531)) of Fyn increases, and this correlates with a substantial reduction in the kinase activity of Fyn and a profound inhibition of ZAP-70 activation.	Tyrosine	73-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	176-179
21423209-3	2011	beta-Catenin has also been shown to be regulated through tyrosine phosphorylation by the receptor tyrosine kinases Met, Fer and Fyn.	Tyrosine	57-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
21692989-8	2011	Finally, we show that tyrosine phosphorylation influences the localization of tau to detergent-resistant membrane microdomains in primary cortical neurons, and that this trafficking is Fyn-dependent.	Tyrosine	22-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	185-188
22829191-3	2011	Microarray-based transcriptome profiling of resistant cells revealed that nilotinib- and imatinib-resistant cells showed the upregulation of kinase-encoding genes (AURKC, FYN, SYK, BTK and YES1).	nilotinib	74-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	171-174
22829191-3	2011	Microarray-based transcriptome profiling of resistant cells revealed that nilotinib- and imatinib-resistant cells showed the upregulation of kinase-encoding genes (AURKC, FYN, SYK, BTK and YES1).	Imatinib Mesylate	89-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	171-174
22829191-4	2011	Among them, the upregulation of AURKC and FYN was observed both in nilotinib- and imatinib-resistant cells irrespective of exposure doses, while SYK, BTK and YES1 showed dose-dependent upregulation of expression.	nilotinib	67-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
22829191-4	2011	Among them, the upregulation of AURKC and FYN was observed both in nilotinib- and imatinib-resistant cells irrespective of exposure doses, while SYK, BTK and YES1 showed dose-dependent upregulation of expression.	Imatinib Mesylate	82-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
21692989-0	2011	Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
21501596-0	2011	Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity.	cyanidin-3-o-glucoside	0-20	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
21692989-6	2011	We also show that tau interacts with the SH2 domain of Fyn, and that this association, unlike that of Fyn-SH3, is influenced by Fyn-mediated tyrosine phosphorylation of tau.	Tyrosine	141-149	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
21501596-7	2011	However, kinase assays demonstrated that C3G suppressed Fyn kinase activity and C3G directly binds Fyn kinase noncompetitively with ATP.	Adenosine Triphosphate	132-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
21513984-6	2011	Fyn is necessary for phosphorylation of this tyrosine in Tim-1 and the phosphorylation of Tim-1 varies with the levels of Fyn present in cells.	Tyrosine	45-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
21467134-7	2011	In these rafts also, resveratrol promotes the recruitment, by the integrin alpha(V)beta(3) (revealed by coimmunoprecipitation with an anti-integrin alpha(V)beta(3) antibody), of signaling molecules that include the FAK (focal adhesion kinase), Fyn, Grb2, Ras, and SOS proteins.	Resveratrol	21-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	244-247
21549693-8	2011	The other 5-HT(6) receptor agonist, WAY181187 also increased Fyn kinase activity.	N(1)-(6-chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl)tryptamine	36-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
21513984-6	2011	Fyn is necessary for phosphorylation of this tyrosine in Tim-1 and the phosphorylation of Tim-1 varies with the levels of Fyn present in cells.	Tyrosine	45-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
21289476-2	2011	We also showed that repeated administration of ethanol causes a long-lasting increase in NMDAR activity in the DMS, resulting from ethanol-mediated Fyn phosphorylation of NR2B subunits.	Ethanol	47-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
21523734-2	2011	Dasatinib inhibits c-kit, PDGFbetaR, and EPHA2 and src kinases c-src, c-Yes, Lck, and Fyn.	Dasatinib	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
21289476-2	2011	We also showed that repeated administration of ethanol causes a long-lasting increase in NMDAR activity in the DMS, resulting from ethanol-mediated Fyn phosphorylation of NR2B subunits.	Ethanol	131-138	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
21210072-7	2011	Bbeta15-42 inhibits Rho-kinase activation by dissociating Fyn from Rho and, hence prevents stress-induced loss of endothelial barrier function and also leukocyte migration.	bbeta15-42	0-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
21209619-4	2011	Suppressing endogenous Rho A expression by small interfering RNA (siRNA)-mediated gene silencing blocked the Ca(2+)(o)-induced association of Fyn with E-cadherin and suppressed the Ca(2+)(o)-induced tyrosine phosphorylation of beta-, gamma-, and p120-catenin and formation of intercellular adherens junctions.	Tyrosine	199-207	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
21498869-4	2011	Furthermore, inhibition of Fyn decreased the rate of PBs extrusion and led to formation of larger PBs (PBI and PBII).	Lead	53-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
21498869-4	2011	Furthermore, inhibition of Fyn decreased the rate of PBs extrusion and led to formation of larger PBs (PBI and PBII).	Lead	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
21097520-0	2011	Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
21097520-3	2011	Once Nrf2 completes activation, Fyn phosphorylates tyrosine 568 of Nrf2, resulting in the nuclear export and degradation of Nrf2.	Tyrosine	51-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	32-35
21097520-5	2011	Mutation of tyrosine 213 of Fyn stymied nuclear export, suggesting that tyrosine phosphorylation controls nuclear export.	Tyrosine	12-20	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
21097520-5	2011	Mutation of tyrosine 213 of Fyn stymied nuclear export, suggesting that tyrosine phosphorylation controls nuclear export.	Tyrosine	72-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
21074588-6	2011	A second pool of CB1Rs, coupled to PTX-sensitive activation of G(i/o), utilized as effectors additional Src and Fyn molecules to generate a second, additional wave of ERK activation at 15 min.	ptx	35-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
21799250-4	2011	In addition, Fyn plays a role in the regulation of Abeta production and mediates Abeta-induced synaptic deficits and neurotoxicity.	UNII-042A8N37WH	51-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
21799250-4	2011	In addition, Fyn plays a role in the regulation of Abeta production and mediates Abeta-induced synaptic deficits and neurotoxicity.	UNII-042A8N37WH	81-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
21799250-5	2011	Fyn also induces tyrosine phosphorylation of tau.	Tyrosine	17-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
21152094-1	2010	BACKGROUND: One of the earliest activation events following stimulation of the T cell receptor (TCR) is the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3-associated complex by the Src family kinase Lck.	Tyrosine	146-154	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	228-231
21098700-0	2010	Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.	Imatinib Mesylate	68-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
21098700-8	2010	Pharmacologic inhibition of this pathway or siRNA-mediated knockdown of Fyn kinase resensitized IM-R cells to imatinib.	Imatinib Mesylate	110-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
21098700-10	2010	Taken together, our results highlight an important role for the Fyn/ERK signaling pathway in imatinib-resistant cells that is driven by accumulation of intracellular SPARC.	Imatinib Mesylate	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
21152094-5	2010	In both T cell types, basal phosphorylation of Lck and Fyn on their activatory tyrosine was observed, although this was much less pronounced in Hut-78 cells.	Tyrosine	79-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
20550964-6	2010	In the mammalian expression system, the trapping mutant of RPTPsigma recognized p250GAP as its physiological substrate in the presence of active Fyn, suggesting that the interaction of the two proteins is primarily dependent on tyrosine phosphorylation.	Tyrosine	228-236	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	145-148
20841362-6	2010	Although microinjection of dominant negative Fyn did not affect initiation of the cleavage furrow, it prolonged the average duration of ingression, decreased the rates of PB extrusion and of the first cleavage, and led to the formation of bigger PBs and longer spindles.	Lead	246-249	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
20814235-4	2010	We determined that this loss in IP(3)-mediated calcium signaling was dependent upon the downregulation of the Src kinase Fyn at the mRNA and protein level.	Inositol 1,4,5-Trisphosphate	32-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
21041515-0	2010	Editorial: Mast cell degranulation and calcium entry--the Fyn-calcium store connection.	Calcium	39-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
21041515-0	2010	Editorial: Mast cell degranulation and calcium entry--the Fyn-calcium store connection.	Calcium	62-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
20814235-4	2010	We determined that this loss in IP(3)-mediated calcium signaling was dependent upon the downregulation of the Src kinase Fyn at the mRNA and protein level.	Calcium	47-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
20814235-5	2010	Because it has previously been shown that Fyn positively regulates IP(3)-mediated calcium release by phosphorylating Type I IP(3) receptors (IP(3)R1), we investigated the effect of glucocorticoids on IP(3)R1 phosphorylation at Tyr353.	Inositol 1,4,5-Trisphosphate	67-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
20814235-5	2010	Because it has previously been shown that Fyn positively regulates IP(3)-mediated calcium release by phosphorylating Type I IP(3) receptors (IP(3)R1), we investigated the effect of glucocorticoids on IP(3)R1 phosphorylation at Tyr353.	Calcium	82-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
20814235-7	2010	Moreover, selective knockdown of Fyn or treatment with a Src inhibitor also attenuated IP(3)-mediated calcium release and induced autophagy.	Inositol 1,4,5-Trisphosphate	87-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
20814235-7	2010	Moreover, selective knockdown of Fyn or treatment with a Src inhibitor also attenuated IP(3)-mediated calcium release and induced autophagy.	Calcium	102-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
19994902-4	2010	Thus, Cr(VI) exposures can induce genes, and we hypothesized that this induction resulted from Cr(VI) signaling through an innate immune-like STAT1-dependent pathway initiated by Fyn.	Chromium	6-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	179-182
20672017-6	2010	From this screen, we have identified novel signaling molecules, such as JAK1, STAT1, cortactin (CTTN), FER, p130Cas (BCAR1), SRC and FYN as tyrosine phosphorylated in human MM cell lines.	Tyrosine	140-148	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	133-136
20028775-5	2010	In contrast to other receptor systems, the TCR-induced phosphorylation of Pyk2 tyrosines 402 and 580 was dependent on the Src family kinases, Fyn or Lck.	Tyrosine	79-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
19538984-7	2010	A delayed response of oxidative/electrophilic stress activates GSK-3beta that phosphorylates Fyn at unknown threonine residue(s).	Threonine	108-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
20049867-6	2010	Functional analysis suggested that genistein-regulated protein tyrosine phosphorylation mainly by inhibiting the activity of tyrosine kinase EGFR, PDGFR, insulin receptor, Abl, Fgr, Itk, Fyn and Src.	Tyrosine	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	187-190
20465253-3	2010	The utility of the approach is demonstrated by an application to the folding reaction of a mutant Fyn SH3 domain, where Ile side-chain structure and dynamics of an on-folding pathway intermediate state are studied.	Isoleucine	120-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
20398064-0	2010	Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	125-128
20398064-4	2010	Src family kinases are important for the tyrosine phosphorylation of SAP-1.	Tyrosine	41-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
20398064-5	2010	Either Grb2 or Fyn, through their Src homology-2 domains, bound to the tyrosine-phosphorylated SAP-1.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
20398064-7	2010	Tyrosine phosphorylation of VE-PTP or PTPRO also promoted their complex formations with Grb2 or Fyn.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-99
20398064-10	2010	Our results thus suggest that tyrosine phosphorylation of R3 subtype RPTPs promotes their complex formations with Grb2 or Fyn and thus participates in the regulation of cell morphology.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
20372074-6	2010	Fyn was recruited during telophase to the cortical area surrounding the midzone of the spindle and was then translocated to the contractile ring during extrusion of PBI.	pbi	165-168	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
20372074-7	2010	GVBD, exit from MI and PBI extrusion were inhibited in oocytes exposed to the chemical inhibitor SU6656 or microinjected with dominant negative Fyn cRNA.	pbi	23-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	144-147
20346773-1	2010	The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn.	Tyrosine	97-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
20346773-1	2010	The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn.	Tyrosine	97-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
19994902-4	2010	Thus, Cr(VI) exposures can induce genes, and we hypothesized that this induction resulted from Cr(VI) signaling through an innate immune-like STAT1-dependent pathway initiated by Fyn.	Chromium	95-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	179-182
19994902-8	2010	Finally, shRNA knockdown of Fyn in BEAS-2B cells prevented Cr(VI)-activated STAT1 transactivation of IRF7.	chromium hexavalent ion	59-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
19994902-9	2010	These data support a novel mechanism through which Cr(VI) stimulates Fyn to initiate interferon-like signaling for STAT1-dependent gene transactivation.	chromium hexavalent ion	51-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
19666107-10	2009	GSK3beta phosphorylates Fyn at an unknown threonine residue(s), leading to the nuclear localization of Fyn.	Threonine	42-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
20110615-4	2010	Recent reports state that tau can be phosphorylated at tyrosine residues by kinases including Fyn, Syk, and c-abl (Abl).	Tyrosine	55-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
19816407-6	2009	Synapse formation by PTPRT was inhibited by phosphorylation of tyrosine 912 within the membrane-proximal catalytic domain of PTPRT by Fyn.	Tyrosine	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	134-137
19816407-8	2009	These results suggest that brain-specific PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase Fyn.	Tyrosine	196-204	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	253-256
19888448-5	2009	Following a leptin stimulus, Fyn undergoes an activating tyrosine phosphorylation and a transient association with IRS1.	Tyrosine	57-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
19666107-10	2009	GSK3beta phosphorylates Fyn at an unknown threonine residue(s), leading to the nuclear localization of Fyn.	Threonine	42-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	103-106
19666107-11	2009	Fyn phosphorylates Nrf2 tyrosine 568, resulting in the nuclear export of Nrf2, binding with INrf2, and degradation of Nrf2.	Tyrosine	24-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19748888-4	2009	We show in this report that enhanced tyrosine phosphorylation mediated by Src, Fyn, and Yes kinases was able to restore the surface expression of D553N for normal current expression.	Tyrosine	37-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
19748888-8	2009	Src, Fyn, and Yes significantly enhanced the tyrosine phosphorylation of D553N.	Tyrosine	45-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
19181669-0	2009	Fyn tyrosine kinase regulates the surface expression of glycosylphosphatidylinositol-linked ephrin via the modulation of sphingomyelin metabolism.	glycosylphosphatidylinositol-linked ephrin	56-98	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19652227-0	2009	Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	35-38
19652227-0	2009	Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.	Tyrosine	118-126	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	35-38
19652227-4	2009	In our research, we demonstrated that Fyn phosphorylated CRMP2 at Tyr(32) residues in HEK293T cells.	Tyrosine	66-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
19652227-7	2009	These results suggest that Fyn-dependent phosphorylation of CRMP2 at Tyr(32) is involved in Sema3A signaling.	Tyrosine	69-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
19433058-5	2009	These changes in sterol composition were accompanied by disruption of lipid rafts, with redistribution of caveolin-1 and Fyn, impairment of insulin-Akt signaling and the inhibition of insulin-stimulated glucose transport.	Sterols	17-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
19501919-3	2009	Recently, we found that Fyn is required for the signal transduction in striatal neurons that is initiated by haloperidol, an antipsychotic drug.	Haloperidol	109-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
19567819-0	2009	Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.	Imatinib Mesylate	29-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
19567819-0	2009	Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.	PD 166326	42-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
19567819-9	2009	Small interfering RNA experiments and pharmacologic approaches identified FYN as a candidate for resistance to imatinib.	Imatinib Mesylate	111-119	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
19330793-0	2009	The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients.	Lithium	67-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
19330793-3	2009	The aim of this study was to find possible association of three polymorphisms of FYN gene with prophylactic lithium response in the group of bipolar patients.	Lithium	108-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
19330793-10	2009	The results of the study demonstrated only marginal association between FYN polymorphisms and prophylactic lithium response in bipolar patients.	Lithium	107-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
19690143-6	2009	The SFK inhibitor dasatinib inhibited invasion, promoted tumor regression, and induced apoptosis in vivo, significantly prolonging survival of an orthotopic glioblastoma model expressing endogenous EGFRvIII.	Dasatinib	18-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
19465689-5	2009	L317 increases binding to calmodulin, whereas N322 attenuates binding to Fyn/Lyn.	3-Fluoro-4-nitropyridine	46-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
19181669-5	2009	The expression of constitutively active Fyn decreases the surface amount of ephrin-As.	ephrin-as	76-85	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
19181669-8	2009	The expression of constitutively active Fyn increases the amount of sphingomyelin clusters on the plasma membrane, whereas inhibiting Fyn decreases it.	Sphingomyelins	68-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
19181669-10	2009	Altogether, these results suggest that Fyn regulates the surface amount of ephrin-As by modulating the metabolism of sphingomyelin, which presumably inhibits the trafficking of ephrin-As from endosomes to the plasma membrane.	Sphingomyelins	117-130	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
19181669-0	2009	Fyn tyrosine kinase regulates the surface expression of glycosylphosphatidylinositol-linked ephrin via the modulation of sphingomyelin metabolism.	Sphingomyelins	121-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19181669-4	2009	Here, we report that the activity of Src family protein-tyrosine kinases, particularly Fyn, negatively regulates the cell-surface amount of ephrin-As.	ephrin-as	140-149	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
19181669-4	2009	Here, we report that the activity of Src family protein-tyrosine kinases, particularly Fyn, negatively regulates the cell-surface amount of ephrin-As.	ephrin-as	140-149	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
19174152-0	2009	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha.	delphinidin	43-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19174152-2	2009	Here we report that Fyn kinase - one of the members of the nonreceptor protein tyrosine kinase family - is involved in TNF-alpha-induced COX-2 expression, and that delphinidin - a major anthocyanidin present in red wine and berries - inhibits these effects by directly inhibiting Fyn kinase activity.	delphinidin - a	164-179	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
19174152-2	2009	Here we report that Fyn kinase - one of the members of the nonreceptor protein tyrosine kinase family - is involved in TNF-alpha-induced COX-2 expression, and that delphinidin - a major anthocyanidin present in red wine and berries - inhibits these effects by directly inhibiting Fyn kinase activity.	delphinidin - a	164-179	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	280-283
19174152-2	2009	Here we report that Fyn kinase - one of the members of the nonreceptor protein tyrosine kinase family - is involved in TNF-alpha-induced COX-2 expression, and that delphinidin - a major anthocyanidin present in red wine and berries - inhibits these effects by directly inhibiting Fyn kinase activity.	Anthocyanins	186-199	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
19174152-5	2009	Kinase and pull-down assay data revealed that delphinidin inhibited Fyn kinase activity and directly bound with Fyn kinase noncompetitively with ATP.	delphinidin	46-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
19174152-5	2009	Kinase and pull-down assay data revealed that delphinidin inhibited Fyn kinase activity and directly bound with Fyn kinase noncompetitively with ATP.	delphinidin	46-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
19174152-7	2009	Together these findings suggest that the targeted inhibition of Fyn kinase activity and COX-2 expression by delphinidin contributes to the chemopreventive potential of red wine and berries.	delphinidin	108-119	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
18849153-0	2009	Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men.	Alcohols	75-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
18849153-1	2009	BACKGROUND: Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol.	Ethanol	166-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	12-15
18849153-1	2009	BACKGROUND: Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol.	Ethanol	231-238	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	12-15
18849153-3	2009	METHODS: We studied the distribution of genotypes and alleles of the polymorphism -93A/G (137346 T/C) in the 5" UTR region of the fyn gene in 207 male heavy drinkers (119 with alcohol dependence and 88 with alcohol abuse) and 100 control subjects from Castilla y Leon (Spain).	Alcohols	176-183	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
18849153-5	2009	CONCLUSION: Our results show that the -93G allele of Fyn kinase gene is associated with higher risk to develop alcohol dependence in Spanish men.	Alcohols	111-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-56
19267471-12	2009	The combination of NMR and ITC data sheds light on how the Fyn tyrosine kinase is activated by binding to proline-rich targets, and represents a powerful approach for characterizing transient protein/ligand interactions.	Proline	106-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
19241379-0	2009	The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state.	trimethyloxamine	13-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
19179337-3	2009	Nephrin, the major component of the SD, is tyrosine-phosphorylated by a Src family tyrosine kinase, Fyn, in developing or injured podocytes, recruiting Nck to Nephrin via its Src homology 2 domain to regulate dynamic actin remodeling.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
19179337-3	2009	Nephrin, the major component of the SD, is tyrosine-phosphorylated by a Src family tyrosine kinase, Fyn, in developing or injured podocytes, recruiting Nck to Nephrin via its Src homology 2 domain to regulate dynamic actin remodeling.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
19131339-8	2009	Importantly, knockdown of Sp1 or Egr1 with small interference RNA or inhibition of Sp1 binding by mithramycin A repressed Fyn protein expression.	mithramycin A	98-111	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
18930841-8	2009	Both phosphorylated FAK residue Y397 and FAK proline-rich domain are involved in Fyn binding.	Proline	45-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
19241379-4	2009	Here we have measured the effects on folding kinetics of 16 different amino acid substitutions distributed across the structure of the Fyn SH3 domain both in the presence and absence of TMAO.	trimethyloxamine	186-190	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
18840710-0	2009	Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck.	Dexamethasone	0-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
19073879-0	2009	Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.	caffeic acid	0-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
19073879-3	2009	In this study, we found that Fyn, one of the members of the non-receptor protein tyrosine kinase family, was required for ultraviolet (UV) B-induced cyclooxygenase-2 (COX-2) expression, and caffeic acid suppressed UVB-induced skin carcinogenesis by directly inhibiting Fyn kinase activity.	caffeic acid	190-202	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
19073879-6	2009	Fyn kinase activity was suppressed more effectively by caffeic acid than by chlorogenic acid, and downstream mitogen-activated protein kinases (MAPKs) were subsequently blocked.	caffeic acid	55-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19073879-6	2009	Fyn kinase activity was suppressed more effectively by caffeic acid than by chlorogenic acid, and downstream mitogen-activated protein kinases (MAPKs) were subsequently blocked.	Chlorogenic Acid	76-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
19073879-7	2009	Pharmacological Fyn kinase inhibitor (3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and leflunomide) data also revealed that Fyn is involved in UVB-induced COX-2 expression mediated through the phosphorylation of MAPKs in JB6 P+ cells.	3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine	38-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	155-158
19073879-8	2009	Pull-down assays revealed that caffeic acid directly bound with Fyn and non-competitively with adenosine triphosphate.	caffeic acid	31-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
18948252-1	2008	Insulin stimulation results in the activation of cyclin-dependent kinase-5 (CDK5) in lipid raft domains via a Fyn-dependent phosphorylation on tyrosine residue 15.	Tyrosine	143-151	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
18948260-4	2008	We find that RPTPalpha, in a growth factor-specific manner, directs the specificity of these kinases toward a specific subset of SFK substrates, particularly the focal adhesion protein Paxillin and the lipid raft scaffolding protein Cbp/PAG.	phenylacetylglycine	237-240	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
18948260-7	2008	Finally, RPTPalpha-induced phosphorylation of Paxillin and Cbp/PAG induces recruitment of the SFK inhibitory kinase Csk, indicative of negative feedback loops limiting SFK activation by RPTPalpha.	phenylacetylglycine	63-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
19468241-2	2009	The Src family tyrosine kinase FYN plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate.	N-Methylaspartate	140-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
19468241-2	2009	The Src family tyrosine kinase FYN plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate.	N-Methylaspartate	140-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
18922801-9	2008	We further demonstrate that tyrosine phosphorylation of Neph1 mediated by Fyn results in significantly increased Neph1 and ZO-1 binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 complex.	Tyrosine	28-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
18922801-9	2008	We further demonstrate that tyrosine phosphorylation of Neph1 mediated by Fyn results in significantly increased Neph1 and ZO-1 binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 complex.	Tyrosine	174-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
19047645-3	2008	NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas).	davunetide	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	164-167
19047645-3	2008	NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas).	nap	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	164-167
19047645-5	2008	Concentrations of ethanol attained after social drinking blocked NAP-mediated axon outgrowth (IC(50) = 17 mM) by inhibiting NAP activation of Fyn kinase and Cas.	Ethanol	18-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	142-145
18337055-3	2008	Therefore, we assessed the impact of 5-Aza-2"-deoxycytidine (5-dAzaC), a DNA methyltransferase (DNMTs) inhibitor on Fyn expression in Hut-78 T-lymphoma cells.	Decitabine	37-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
18337055-3	2008	Therefore, we assessed the impact of 5-Aza-2"-deoxycytidine (5-dAzaC), a DNA methyltransferase (DNMTs) inhibitor on Fyn expression in Hut-78 T-lymphoma cells.	5-dazac	61-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
18337055-5	2008	However, bisulfite sequencing revealed that Hut-78 T-lymphoma cells cultured in the absence of 5-dAzaC contained unmethylated cytosine in the cytosine-guanosine dinucleotide island of the Fyn promoter.	cytosine-guanosine dinucleotide	142-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
18564062-0	2008	Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells.	Hydrogen Peroxide	24-28	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-11
18829466-5	2008	First, we demonstrated that H2O2-induced nuclear export of TERT was abolished in Src, Fyn, and Yes-deficient embryonic fibroblasts.	Hydrogen Peroxide	28-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
18564062-11	2008	Our results, for the first time, provide evidence for H(2)O(2)-induced Src kinase Fyn/PI3K complex association.	Hydrogen Peroxide	54-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
18564062-7	2008	H(2)O(2)-mediated inhibition of Cl(-)/OH(-) exchange activity involved the Src kinase Fyn and PI3K (phosphoinositide 3-kinase)-dependent pathways.	Hydrogen Peroxide	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
18564062-8	2008	H(2)O(2) also induced phosphorylation of Fyn and p85 (the regulatory subunit of PI3K) in Caco-2 cells.	Hydrogen Peroxide	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
18550847-0	2008	Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.	Cyclic GMP	88-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
18721137-0	2008	Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity.	phenylacetylglycine	64-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	52-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	52-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-164
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	52-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	259-262
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	ptyr317	56-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	ptyr317	56-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-164
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	ptyr317	56-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	259-262
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	183-186	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	183-186	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-164
18721137-2	2008	Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn.	phenylacetylglycine	183-186	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	259-262
18721137-3	2008	In this study, we investigated Fyn SH3-domain binding to 14-mer peptide ligands derived from Cbp/PAG-enriched microdomains sequence using biochemical, biophysical and computational techniques.	phenylacetylglycine	97-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
18721137-7	2008	The presented data demonstrate a potential method for modulation of Src family kinase tyrosine phosphorylation through minor changes of the substrate SH3-interacting motif.	Tyrosine	86-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
18506685-0	2008	Lysophosphatidic acid induces ovarian cancer cell dispersal by activating Fyn kinase associated with p120-catenin.	lysophosphatidic acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
18506685-6	2008	We identified the Src family kinase, Fyn, as the key component associated with p120-catenin after LPA stimulation in SKOV3 cells.	lysophosphatidic acid	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
18506685-7	2008	Our study provides evidence that LPA induces junction dispersal in ovarian cancer SKOV3 cells by activating the Src family kinase Fyn and increasing its association with p120-catenin at the cell-cell junction.	lysophosphatidic acid	33-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
18621907-7	2008	The siRNA targeting Fyn prevented the cytokine-induced increase in urea and NO production, whereas siRNAs specifically targeting Yes, c-Src, and Lyn had no appreciable effect on cytokine-induced urea and NO production.	Urea	67-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
18593733-6	2008	Signaling through ephrin-A induces phosphorylation of several proteins, including the Src kinases Lck and Fyn.	ephrin-a	18-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
18593733-8	2008	An ephrin-A signaling complex could be isolated, containing several phosphorylated proteins including Lck and Fyn.	ephrin-a	3-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
18089558-4	2008	Fyn induced phosphorylation of APP at Tyr-757 of the (757)YENPTY(762) motif and increased cell surface expression of APP.	Tyrosine	38-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
18326860-6	2008	Two SRC family PTK (SFK)-selective inhibitors, PP2 and SU6656, blocked LPS-induced increments in tyrosine phosphorylation of VE-cadherin and p120(ctn) and paracellular permeability.	SU 6656	55-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
18326860-6	2008	Two SRC family PTK (SFK)-selective inhibitors, PP2 and SU6656, blocked LPS-induced increments in tyrosine phosphorylation of VE-cadherin and p120(ctn) and paracellular permeability.	Tyrosine	97-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
18326860-6	2008	Two SRC family PTK (SFK)-selective inhibitors, PP2 and SU6656, blocked LPS-induced increments in tyrosine phosphorylation of VE-cadherin and p120(ctn) and paracellular permeability.	trans-crotonin	146-149	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
18326860-8	2008	Selective small interfering RNA-induced knockdown of c-SRC, FYN, or YES diminished LPS-induced SRC Tyr(416) phosphorylation, tyrosine phosphorylation of VE-cadherin and p120(ctn), and barrier disruption, whereas knockdown of LYN did not.	Tyrosine	99-102	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
18502612-0	2008	Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.	sphingosine 1-phosphate	0-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
18407307-0	2008	Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells.	Arsenic	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
18407307-10	2008	This study demonstrates that repeated and prolonged exposure to arsenic alters cell populations and produces functional changes depending on the specific activation pathway, and could be related with the phosphorylation status of lck and fyn kinases.	Arsenic	64-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	238-241
18326860-8	2008	Selective small interfering RNA-induced knockdown of c-SRC, FYN, or YES diminished LPS-induced SRC Tyr(416) phosphorylation, tyrosine phosphorylation of VE-cadherin and p120(ctn), and barrier disruption, whereas knockdown of LYN did not.	Tyrosine	125-133	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
18326860-8	2008	Selective small interfering RNA-induced knockdown of c-SRC, FYN, or YES diminished LPS-induced SRC Tyr(416) phosphorylation, tyrosine phosphorylation of VE-cadherin and p120(ctn), and barrier disruption, whereas knockdown of LYN did not.	trans-crotonin	174-177	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
18326860-13	2008	These data indicate that LPS recognition by TLR4 activates the SFKs, c-SRC, FYN, and YES, which, in turn, contribute to tyrosine phosphorylation of zonula adherens proteins to open the endothelial paracellular pathway.	Tyrosine	120-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
18182400-4	2008	Coexposure, but not exposure to either agent alone, rapidly increased active Fyn tyrosine kinase, tyrosine phosphorylation of a 109-kDa protein and serine phosphorylation of protein kinase C (PKC)delta.	Tyrosine	81-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-80
18377769-4	2008	Fyn and Lyn counter-regulate phosphatidylinositol 3-OH kinase (PI3K), controlling the produced amount of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a key regulator of mast cell degranulation.	phosphatidylinositol 3,4,5-triphosphate	105-147	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
18377769-4	2008	Fyn and Lyn counter-regulate phosphatidylinositol 3-OH kinase (PI3K), controlling the produced amount of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a key regulator of mast cell degranulation.	PIP3	149-153	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
18377769-5	2008	Fyn and Lyn also activate sphingosine kinases (SphK), which generate sphingosine-1-phosphate (S1P), thus contributing to mast cell chemotaxis and degranulation.	sphingosine 1-phosphate	69-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
18253061-5	2008	In addition, we show that tyrosine-phosphorylated DCC selectively interacts with the Src family kinases Fyn and Lck, but not Src, c-Abl, Grb2, SHIP1, Shc, or tensin, suggesting a role of Fyn or Lck in netrin-1-DCC signaling.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107
18156174-7	2008	By mass spectroscopy-based studies, we identified Src tyrosine kinase family members Src and Fyn as upstream kinases of RSK2 Tyr-529.	Tyrosine	125-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
18156174-9	2008	Src and Fyn were able to directly phosphorylate RSK2 at Tyr-529 in the in vitro kinase assay.	Tyrosine	56-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-11
18065418-9	2008	Inhibition of CaR expression blocked the Ca(2+)(o)-induced tyrosine phosphorylation of beta-, gamma-, and p120-catenin, PI3K, and the tyrosine kinase Fyn and the association of Fyn with E-cadherin and PI3K.	Tyrosine	59-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
17943724-6	2008	Moreover, genomic bisulfite sequencing revealed frequent aberrant methylation of a large CpG island in the FYN promoter region in both adenocarcinoma cell lines (3 of 5 cell lines tested) and primary prostate cancer (12 of 18 tumors).	hydrogen sulfite	18-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
18067320-8	2008	Molecular docking simulations of the interaction of the putative SH3 ligand of classic MBP with the human Fyn SH3 domain indicate that the strength of the interaction is of the same order of magnitude as with calmodulin and that the molecular recognition and association is mediated by some weak CH...pi interactions between the ligand prolyl residues and the aromatic ones of the SH3 binding site.	Peptide oostatic hormone	336-342	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
18301737-3	2008	Previous reports have shown that the formation of this heteromolecular complex involves interactions between a proline rich region of M2 and the Vav1 and Fyn SH3 domains.	Proline	111-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	154-157
18085663-5	2008	Despite being displaced, the mutant PAG molecule still binds the Src kinase Fyn and the cytoskeletal adaptor ezrin-radixin-moesin-binding phosphoprotein of 50 kDa, becomes tyrosine-phosphorylated, and recruits Csk to the membrane.	phenylacetylglycine	36-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
18253061-5	2008	In addition, we show that tyrosine-phosphorylated DCC selectively interacts with the Src family kinases Fyn and Lck, but not Src, c-Abl, Grb2, SHIP1, Shc, or tensin, suggesting a role of Fyn or Lck in netrin-1-DCC signaling.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	187-190
18253061-6	2008	Of interest to note is that tyrosine-phosphorylated neogenin and uncoordinated 5 H2 (Unc5H2) not only bind to the Src homology 2 (SH2) domains of Fyn and SHP2, but also interact with the SH2 domain of SHIP1, suggesting a differential signaling between DCC and neogenin/Unc5H2.	Tyrosine	28-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	146-149
17923684-4	2007	Upon engagement, Neph1 is phosphorylated on specific tyrosine residues by Fyn, which results in the recruitment of Grb2, an event that is necessary for Neph1-induced actin polymerization at the plasma membrane.	Tyrosine	53-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	23-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
17948968-6	2007	The known stabilization of the N-terminal domain of CaM in the context of the intact protein and the known binding affinity of a proline-rich peptide to the SH3 domain in the Fyn construct were successfully quantified using the new protocol.	Proline	129-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	175-178
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	23-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	0-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	23-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	lysophosphatidic acid	23-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	32-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	32-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	32-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	32-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17950286-1	2007	Lysophosphatidic acid (LPA) and sphingosylphosphorylcholine (SPC) activated Fyn tyrosine kinase and induced stress fiber formation, which was blocked by pharmacological inhibition of Fyn, gene silencing of Fyn, or dominant negative Fyn.	sphingosine phosphorylcholine	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
17875741-10	2007	EphA4 activation decreases tyrosine phosphorylation of the scaffolding protein Crk-associated substrate (Cas) and the tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) and also reduces the association of Cas with the Src family kinase Fyn and the adaptor Crk.	Tyrosine	27-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	272-275
17706593-2	2007	Pleiotrophin signals through inactivating its receptor, the receptor protein tyrosine phosphatase (RPTP)beta/zeta, leading to increased tyrosine phosphorylation of different substrate proteins of RPTPbeta/zeta, including beta-catenin, beta-adducin, Fyn, GIT1/Cat-1, and P190RhoGAP.	Tyrosine	77-85	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	249-252
17959796-6	2007	Coexpression of Fyn with Na(V)1.2 channels decreases sodium currents by increasing the rate of inactivation and causing a negative shift in the voltage dependence of inactivation.	Sodium	53-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
17959796-8	2007	These results indicate that Fyn kinase is associated with sodium channels in brain neurons and can modulate Na(V)1.2 channels by tyrosine phosphorylation after activation of TrkB/p75 signaling by BDNF.	Tyrosine	129-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
17959797-2	2007	Fast inactivation of Na(V)1.2 channels is regulated via tyrosine phosphorylation by Fyn kinase and dephosphorylation by receptor phosphoprotein tyrosine phosphatase-beta, which are associated in a signaling complex.	Tyrosine	56-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
17959797-3	2007	Here we have identified the amino acid residues on Na(V)1.2 channels that coordinate binding of Fyn kinase and mediate inhibition of sodium currents by enhancing fast inactivation.	Sodium	133-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-99
17959797-4	2007	Fyn kinase binds to a Src homology 3 (SH3)-binding motif in the second half of the intracellular loop connecting domains I and II (L(I-II)) of Na(V)1.2, and mutation of that SH3-binding motif prevents Fyn binding and Fyn enhancement of fast inactivation of sodium currents.	Sodium	257-263	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
17631858-4	2007	The DHA content of the raft lipids increased 25-fold and was accompanied by a redistribution of src and fyn out of the rafts.	Docosahexaenoic Acids	4-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	104-107
17371836-4	2007	Tyrosine phosphorylation of Sam68 by Fyn inverted this effect and favored the Bcl-x(L) splice site selection.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
17847712-0	2007	N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase.	n-acyl-3,5-bis(arylidene)-4-piperidones	0-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	78-81
17847712-4	2007	Molecular modelling suggested that the compounds interact transiently with the ATP binding site of fyn kinase thereby enhancing the catalytic phosphorylation of proteins.	Adenosine Triphosphate	79-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
17389760-2	2007	Because Fyn is the kinase primarily responsible for the phosphorylation of PAG (the phosphoprotein associated with glycosphingolipid-enriched microdomains), which negatively regulates Src-kinase activity by recruiting Csk (the C-terminal Src kinase) to the membrane, we investigated whether anergy induction also affects PAG.	Glycosphingolipids	115-132	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-11
17389760-4	2007	This together with enhanced phosphorylation of a tyrosine within the SH2 domain of Fyn leads to the formation of a hyperactive conformation, thus explaining the enhanced Fyn kinase activity.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-86
17389760-4	2007	This together with enhanced phosphorylation of a tyrosine within the SH2 domain of Fyn leads to the formation of a hyperactive conformation, thus explaining the enhanced Fyn kinase activity.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	170-173
17417065-2	2007	The Src-family tyrosine kinase Fyn plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate, in prefrontal cortex.	N-Methylaspartate	140-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
17417065-2	2007	The Src-family tyrosine kinase Fyn plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor N-methyl-D-aspartate, in prefrontal cortex.	N-Methylaspartate	140-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
17320499-6	2007	A preliminary analysis of the current biomedical literature in our research area using our tool suggests that S100A12, as well as a group of SMAD genes previously unstudied in relation to osteoporosis, may be highly relevant to the mechanism of action of bisphosphonates, that the function of osteocytes may be influenced by a family of important interleukins and interleukin-related molecules, and that the FYN oncogene may play an important role in regulating the apoptosis of bone cells in the context of degenerative bone diseases.	Diphosphonates	255-270	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	408-411
17403689-4	2007	Tyrosine kinase Fyn phosphorylates tyrosine 568 of Nrf2 that leads to the nuclear export of Nrf2.	Tyrosine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
17403689-12	2007	The activated GSK-3beta phosphorylates Fyn at threonine residue(s).	Threonine	46-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
17403689-13	2007	Phosphorylated Fyn accumulates in the nucleus and phosphorylates Nrf2 at tyrosine 568.	Tyrosine	73-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
17233630-2	2007	SFK activity is controlled by Csk (C-terminal Src kinase), which phosphorylates a C-terminal tyrosine residue on SFKs, resulting in inhibition of SFK activity.	Tyrosine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
17233630-2	2007	SFK activity is controlled by Csk (C-terminal Src kinase), which phosphorylates a C-terminal tyrosine residue on SFKs, resulting in inhibition of SFK activity.	Tyrosine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
17233630-3	2007	Csk is recruited to sites of SFK activity by tyrosine-phosphorylated Csk-binding proteins.	Tyrosine	45-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
17290413-4	2007	Here we show that the FcRgamma/Fyn signaling cascade is critically involved in cuprizone-induced demyelination/remyelination, with no lymphocytic response.	Cuprizone	79-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
17182189-5	2007	(19)F NMR spectra of Fyn SH3 were also obtained as a function of concentration of a small peptide (2-hydroxynicotinic-NH)-Arg-Ala-Leu-Pro-Pro-Leu-Pro-diaminopropionic acid -NH(2), known to interact with the canonical polyproline II (PPII) helix binding site of the SH3 domain.	2-hydroxynicotinic-nh)-arg-ala-leu-pro-pro-leu-pro-diaminopropionic acid -nh	99-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
17315853-0	2007	Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes.	rosmarinic acid	62-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
17315853-0	2007	Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes.	rosmarinic acid	62-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-90
17315853-5	2007	Rosmarinic acid, a secondary metabolite of herbal plants, was discovered as a new Fyn kinase inhibitor using immunochemical and in silico methods.	rosmarinic acid	0-15	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
17315853-6	2007	Two possible binding modes of rosmarinic acid were evaluated here, i.e., near to or in the ATP-binding site of kinase domain of Fyn.	rosmarinic acid	30-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
17315853-6	2007	Two possible binding modes of rosmarinic acid were evaluated here, i.e., near to or in the ATP-binding site of kinase domain of Fyn.	Adenosine Triphosphate	91-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
17315853-7	2007	Enzyme kinetic experiments revealed that Fyn is inhibited by a linear-mixed noncompetitive mechanism of inhibition by rosmarinic acid.	rosmarinic acid	118-133	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
17315853-8	2007	This indicates that rosmarinic acid binds to the second "non-ATP" binding site of the Fyn tyrosine kinase.	rosmarinic acid	20-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
17315853-8	2007	This indicates that rosmarinic acid binds to the second "non-ATP" binding site of the Fyn tyrosine kinase.	Adenosine Triphosphate	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
17182189-5	2007	(19)F NMR spectra of Fyn SH3 were also obtained as a function of concentration of a small peptide (2-hydroxynicotinic-NH)-Arg-Ala-Leu-Pro-Pro-Leu-Pro-diaminopropionic acid -NH(2), known to interact with the canonical polyproline II (PPII) helix binding site of the SH3 domain.	polyproline ii	217-231	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
17182189-5	2007	(19)F NMR spectra of Fyn SH3 were also obtained as a function of concentration of a small peptide (2-hydroxynicotinic-NH)-Arg-Ala-Leu-Pro-Pro-Leu-Pro-diaminopropionic acid -NH(2), known to interact with the canonical polyproline II (PPII) helix binding site of the SH3 domain.	ppii	233-237	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
16912036-7	2006	The positions of these tyrosines in the crystal structure of the c-Abl core and the transformation defect of the corresponding Bcr-Abl mutants together suggest that phosphorylation of the SH3-SH2 region by Src family kinases impacts Bcr-Abl protein conformation and signaling.	Tyrosine	23-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	206-209
17197511-11	2007	DHA(22:6,n3) enrichment in the caveolae/raft was accompanied by a 70% depletion of cholesterol from caveolae/lipid rafts and displacement of the SFK, Fyn, and c-Yes from caveolae/lipid rafts.	dehydroacetic acid	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	145-148
17197511-11	2007	DHA(22:6,n3) enrichment in the caveolae/raft was accompanied by a 70% depletion of cholesterol from caveolae/lipid rafts and displacement of the SFK, Fyn, and c-Yes from caveolae/lipid rafts.	dehydroacetic acid	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
16987982-7	2006	In addition, Vpx interacts with the cellular tyrosine kinase Fyn through its C-terminal proline-rich motif.	Proline	88-95	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
16989862-1	2006	Recent 15N and 13C spin-relaxation dispersion studies of fast-folding mutants of the Fyn SH3 domain have established that folding proceeds through a low-populated on-pathway intermediate (I) where the central beta-sheet is at least partially formed, but without interactions between the NH2- and COOH-terminal beta-strands that exist in the folded state (F).	15n	7-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
16989862-1	2006	Recent 15N and 13C spin-relaxation dispersion studies of fast-folding mutants of the Fyn SH3 domain have established that folding proceeds through a low-populated on-pathway intermediate (I) where the central beta-sheet is at least partially formed, but without interactions between the NH2- and COOH-terminal beta-strands that exist in the folded state (F).	13c	15-18	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
16782058-0	2006	Structure of human Fyn kinase domain complexed with staurosporine.	Staurosporine	52-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
16762377-5	2006	Inhibitors for a non-receptor type tyrosine kinase, Fyn, and janus-activated kinase 2, suppressed the neuroprotective effect of donepezil and galanthamine, but not that of tacrine.	Donepezil	128-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
16762377-5	2006	Inhibitors for a non-receptor type tyrosine kinase, Fyn, and janus-activated kinase 2, suppressed the neuroprotective effect of donepezil and galanthamine, but not that of tacrine.	Galantamine	142-154	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
16899073-8	2006	In a human embryonic kidney (HEK) 293 cell expression system, PTPalpha enhanced fyn-mediated NR2A and NR2B tyrosine phosphorylation by several-fold.	Tyrosine	107-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
16860569-4	2006	We find that Fyn expression is sufficient to allow transactivation of Trk by adenosine and that Fyn and Trk are colocalized in a juxtanuclear membrane compartment.	Adenosine	77-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
16860569-5	2006	Adenosine activation of Fyn results in direct phosphorylation of Trk in vitro and follows a delayed time course that coincides with Trk activation.	Adenosine	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
16782058-4	2006	Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution.	Staurosporine	84-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
16782058-5	2006	Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes.	Staurosporine	0-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
16782058-5	2006	Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes.	Adenosine Triphosphate	27-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
16316995-0	2006	IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.	sphingosine 1-phosphate	73-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
16543952-4	2006	Our data support the model that during podocyte intercellular junction formation, engagement of the nephrin ectodomain induces transient Fyn catalytic activity that results in nephrin phosphorylation on specific nephrin cytoplasmic domain tyrosine residues.	Tyrosine	239-247	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
16539378-2	2006	Synthetic peptides containing tyrosine analogues displaying different side chain orientations were analyzed by NMR techniques and tested as potential substrates of the nonreceptor tyrosine kinases Syk, Csk, Lyn, and Fyn.	Peptides	10-18	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	216-219
16479011-3	2006	Using an antiphosphotyrosine antibody to screen tyrosine-phosphorylated cDNA expression library, we have identified Tom1L1, an adaptor protein of the Tom1 family and a novel substrate and activator of the SFK.	Tyrosine	20-28	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	205-208
16765915-0	2006	Fyn-induced phosphorylation of beta-adducin at tyrosine 489 and its role in their subcellular localization.	Tyrosine	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
16765915-3	2006	In the present report, we show that Fyn phosphorylates beta-adducin at tyrosine 489 located in its C-terminal tail domain.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
16439036-6	2006	Furthermore, carbachol increased tyrosine-phosphorylation of Fyn, a member of the Src-like tyrosine kinases.	Carbachol	13-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
16439036-6	2006	Furthermore, carbachol increased tyrosine-phosphorylation of Fyn, a member of the Src-like tyrosine kinases.	Tyrosine	33-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
16456001-4	2006	In agreement with published results, we found that Fyn also contributes to Gab2 tyrosyl phosphorylation.	cyclo(tyrosyl-tyrosyl)	80-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
16387660-0	2006	Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.	Tyrosine	69-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
16441434-4	2006	We further show that Src, Fyn and Yes have unique specificities towards these tyrosine residues.	Tyrosine	78-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-29
16387660-3	2006	Here we show that Itch is also modulated by an Src kinase Fyn via tyrosine phosphorylation at the Tyr371 residue.	Tyrosine	66-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
16373478-1	2006	Guanidinium hydrochloride (GuHCl) at low concentrations significantly stabilizes the Fyn SH3 domain.	Guanidine	0-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
16373478-1	2006	Guanidinium hydrochloride (GuHCl) at low concentrations significantly stabilizes the Fyn SH3 domain.	Guanidine	27-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
16267051-7	2005	The stimulation of neurite outgrowth and polarity formation induced by cholesterol depletion was accompanied by an enhanced localization of Fyn, a Src kinase, in the lipid rafts of hippocampal neurons.	Cholesterol	71-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
16267051-8	2005	A concomitant treatment with beta-cyclodextrin and a Src family kinase inhibitor, PP2, specifically blocked axon outgrowth but not dendrite outgrowth (both of which were enhanced by beta-cyclodextrin) in hippocampal neurons, suggesting that axon outgrowth modulated by cholesterol is induced in a Fyn-dependent manner.	betadex	29-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-56
16267051-8	2005	A concomitant treatment with beta-cyclodextrin and a Src family kinase inhibitor, PP2, specifically blocked axon outgrowth but not dendrite outgrowth (both of which were enhanced by beta-cyclodextrin) in hippocampal neurons, suggesting that axon outgrowth modulated by cholesterol is induced in a Fyn-dependent manner.	betadex	29-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	297-300
16087662-5	2005	We show that LMP2A is tyrosine-phosphorylated in Jurkat TAg T cells, which requires expression of the Src family tyrosine kinases, Lck and Fyn.	Tyrosine	22-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
16087662-5	2005	We show that LMP2A is tyrosine-phosphorylated in Jurkat TAg T cells, which requires expression of the Src family tyrosine kinases, Lck and Fyn.	Tyrosine	22-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
16087662-6	2005	Lck and Fyn are recruited to the tyrosine-phosphorylated Tyr112 site in LMP2A, whereas phosphorylation of an ITAM motif in LMP2A creates a binding site for the ZAP-70/Syk tyrosine kinases.	Tyrosine	33-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-11
16162939-2	2005	Biochemical and in vitro experiments implicate Src and Fyn in the Reelin-dependent tyrosine phosphorylation of Dab1, which controls the positioning of radially migrating neurons in many brain regions.	Tyrosine	83-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
16145685-6	2005	When co-transfected cells were post-treated with nocodazole, Fyn was not associated with MAP-2c and acetylated, stable tubulin.	Nocodazole	49-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-64
16052566-7	2005	Our data also indicated that ERK activation and the potentiation of ATP calcium responses were sensitive to the src-like kinase inhibitor herbimycin A, p21(ras) farnesyltransferase inhibitor peptide, and some PKC inhibitors.	atp calcium	68-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-127
16052566-7	2005	Our data also indicated that ERK activation and the potentiation of ATP calcium responses were sensitive to the src-like kinase inhibitor herbimycin A, p21(ras) farnesyltransferase inhibitor peptide, and some PKC inhibitors.	herbimycin	138-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-127
16162939-4	2005	Here, we report that, although Src is dispensable and although the absence of Fyn causes an intermediate phenotype, the combined absence of Src and Fyn almost abolishes tyrosine phosphorylation of Dab1 and causes defects in the fetal cortex and cerebellum very similar to those of dab1 mutants of the same age.	Tyrosine	169-177	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
15955811-7	2005	High concentrations of ephrin-B2 induced tyrosine phosphorylation of EphB6 through an Src family kinase activity.	Tyrosine	41-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
15899916-8	2005	Experiments with GC receptor-negative Jurkat cells and a pharmacologic GC receptor ligand (RU486) indicated that rapid inhibition of Lck and Fyn kinases is GC receptor dependent.	Mifepristone	91-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
15955811-8	2005	These results indicate that EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.	Tyrosine	124-132	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	171-174
15925565-0	2005	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin.	Tyrosine	64-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
16014719-2	2005	Besides phosphorylation of tau on serine and threonine residues in both normal tau and tau from neurofibrillary tangles, Tyr-18 was reported to be a site of phosphorylation by the Src-family kinase Fyn.	Tyrosine	121-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	198-201
16014719-8	2005	Cotransfection of tau and kinases showed that Tyr-18 was the major site for Fyn phosphorylation, but Tyr-394 was the main residue for Abl.	Tyrosine	46-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
15886210-12	2005	Small interfering RNA Fyn also suppressed 2-AG-induced ERK phosphorylation.	glyceryl 2-arachidonate	42-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
15925565-0	2005	Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin.	Tyrosine	64-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	156-159
15925565-4	2005	We further demonstrate that Fyn is a substrate of RPTPbeta/zeta, and that tyrosine phosphorylation of Fyn is sharply increased in PTN-stimulated cells.	Tyrosine	74-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
15872086-0	2005	Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.	Calcium	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
15998796-3	2005	By interacting with SLAM family receptors, SAP enables tyrosine phosphorylation signaling of these receptors by its ability to recruit the Src-related kinase, Fyn.	Tyrosine	55-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	159-162
15998803-8	2005	Finally, we show that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway.	Calcium	108-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-29
15872086-3	2005	Our results showed that the combination of dominant negative src and fyn blocked calcium-stimulated PLC-gamma1 activity and human keratinocyte differentiation, whereas each separately has little effect.	Calcium	81-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
15872086-7	2005	The combination of dominant negative src and fyn blocked calcium-induced tyrosine phosphorylation of the regulatory subunit of PI3K, p85alpha, and the activity of the catalytic subunit of PI3K.	Calcium	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
15752743-0	2005	The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into vif-defective HIV-1 particles.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
15872086-7	2005	The combination of dominant negative src and fyn blocked calcium-induced tyrosine phosphorylation of the regulatory subunit of PI3K, p85alpha, and the activity of the catalytic subunit of PI3K.	Tyrosine	73-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
15872086-9	2005	These data indicate that calcium activates PLC-gamma1 via increased PIP3 formation mediated by c-src- and fyn-activated PI3K.	Calcium	25-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
15831816-8	2005	Tyrosine phosphorylation of immunoprecipitated Na(V)1.5 was increased in cells expressing Fyn(CA) compared with Fyn(KD).	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
15831816-8	2005	Tyrosine phosphorylation of immunoprecipitated Na(V)1.5 was increased in cells expressing Fyn(CA) compared with Fyn(KD).	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
15752743-5	2005	Interestingly, we also observed that APOBEC3G can be phosphorylated on tyrosine in the presence of Fyn or Hck, suggesting that both kinases may regulate APOBEC3G function.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	99-102
15671290-11	2005	As judged by immunoprecipitation, Src, Fyn, Lyn, and Lck elicited tyrosine phosphorylation of the Na,K-ATPase alpha1 protein.	Tyrosine	66-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
15632127-6	2005	Interestingly, PP2, a specific Src-like kinase inhibitor, blocked the tyrosine phosphorylation of Src, Fyn, and Lyn and IGF-I-stimulated Akt activation, yet had no significant effects on caspase-3 activation or progenitor survival.	Tyrosine	70-78	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	103-106
15661030-3	2005	SAP also binds to the Src family tyrosine kinase Fyn and recruits it to SLAM, which leads to the generation of downstream phosphotyrosine signals.	Phosphotyrosine	122-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
15661030-3	2005	SAP also binds to the Src family tyrosine kinase Fyn and recruits it to SLAM, which leads to the generation of downstream phosphotyrosine signals.	Phosphotyrosine	122-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
15537652-5	2005	UVB-induced phosphorylation of histone H3 at serine 10 was blocked by either a dominant-negative mutant of Fyn (DNM-Fyn) kinase or small interfering RNA of Fyn kinase.	Serine	45-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
15537652-5	2005	UVB-induced phosphorylation of histone H3 at serine 10 was blocked by either a dominant-negative mutant of Fyn (DNM-Fyn) kinase or small interfering RNA of Fyn kinase.	Serine	45-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
15537652-0	2005	Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.	Serine	69-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
15537652-5	2005	UVB-induced phosphorylation of histone H3 at serine 10 was blocked by either a dominant-negative mutant of Fyn (DNM-Fyn) kinase or small interfering RNA of Fyn kinase.	Serine	45-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
15537652-2	2005	Here we provide evidence that Fyn kinase, a member of the Src kinase family, is involved in the UVB-induced phosphorylation of histone H3 at serine 10.	Serine	141-147	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
15537652-8	2005	Active Fyn kinase phosphorylated histone H3 at serine 10 in vitro, and the phosphorylated Fyn kinase could translocate into the nucleus of HaCaT cells.	HS 3	41-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	7-10
15537652-8	2005	Active Fyn kinase phosphorylated histone H3 at serine 10 in vitro, and the phosphorylated Fyn kinase could translocate into the nucleus of HaCaT cells.	Serine	47-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	7-10
15537652-4	2005	Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation.	-(4-chlorophenyl)-7(t-butyl)pyrazol	31-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
15537652-9	2005	These results indicate that Fyn kinase plays a key role in the UVB-induced phosphorylation of histone H3 at serine 10.	Serine	108-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
15537652-4	2005	Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation.	-(4-chlorophenyl)-7(t-butyl)pyrazol	31-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-202
15466865-5	2004	This interaction requires the phosphorylation of caveolin-1 on tyrosine 14 by members of the Src family of protein kinases, such as Src and Fyn, because it is completely abolished by expression of a catalytically inactive Src mutant or by site-directed mutagenesis of tyrosine 14 of caveolin-1.	Tyrosine	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
15537652-4	2005	Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation.	Leflunomide	86-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
15537652-4	2005	Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation.	Leflunomide	86-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-202
15537652-4	2005	Fyn kinase inhibitors 4-amino-5-(4-chlorophenyl)-7(t-butyl)pyrazol(3,4-d)pyramide and leflunomide, an Src kinase inhibitor, suppressed both UVB-induced phosphorylation of histone H3 at serine 10 and Fyn kinase activity and phosphorylation.	Serine	185-191	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
15536091-0	2005	Fyn phosphorylates human MAP-2c on tyrosine 67.	Tyrosine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
15536091-2	2005	Co-transfections into COS7 cells and in vitro kinase assays performed with Fyn and wild-type, or mutant MAP-2c, determined that Fyn phosphorylated MAP-2c on tyrosine 67.	Tyrosine	157-165	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
15615649-2	2005	Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane.	Proline	16-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
15466865-5	2004	This interaction requires the phosphorylation of caveolin-1 on tyrosine 14 by members of the Src family of protein kinases, such as Src and Fyn, because it is completely abolished by expression of a catalytically inactive Src mutant or by site-directed mutagenesis of tyrosine 14 of caveolin-1.	Tyrosine	268-276	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
15577202-4	2004	These results suggest that CK2 may be a protein kinase responsible for the suppression of at least three Src-TKs (Fyn, Src and Yes) through the specific phosphorylation of their Thr-residues at the cellular level.	Threonine	178-181	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
14761972-4	2004	We found that TRPC6 is tyrosine-phosphorylated in COS-7 cells when coexpressed with Fyn, a member of the Src family PTKs.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
15465914-2	2004	Crosslinking of purified wild-type naive CD4 cells with anti-CD3 activated Lck and initiated the signaling cascade downstream of Lck, including phosphorylation of ZAP-70, LAT, and PLC-gamma1; calcium flux; and dephosphorylation and nuclear translocation of the nuclear factor of activated T cells (NFAT)p. All of these signaling events were diminished severely in Fyn-deficient naive cells activated by CD3 crosslinking.	Calcium	192-199	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	364-367
15902902-4	2004	Results of studies also support the suggestion that the ethanol inhibition on NR1/2A receptors is reduced by Fyn kinase-mediated tyrosine phosphorylation.	Ethanol	56-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
15902902-4	2004	Results of studies also support the suggestion that the ethanol inhibition on NR1/2A receptors is reduced by Fyn kinase-mediated tyrosine phosphorylation.	Tyrosine	129-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
15902902-6	2004	In the current study, the effect of Fyn kinase on the ethanol inhibition of NR1/2A receptors was determined under conditions in which zinc sensitivity is eliminated.	Ethanol	54-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
15242776-7	2004	Binding experiments with recombinant SH2 and SH3 domains of Src and Fyn kinases revealed that protein complexes containing gamma-tubulin bound to SH2 domains and that these interactions were of SH2-phosphotyrosine type.	sh2-phosphotyrosine	194-213	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
15261465-6	2004	The highly homologous C-terminal cytoplasmic region contains nine tyrosines including the YEND/E motif that binds the SH2 domain of Fyn.	Tyrosine	66-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	132-135
14963042-8	2004	The PH and PTB domains of Dok-4 were also required for tyrosine phosphorylation of Dok-4 by Fyn and Ret.	Tyrosine	55-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	92-95
15345239-10	2004	Together, our data indicate that rSLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn).	Tyrosine	108-116	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
15190072-4	2004	We show that the overactive FGFR2 S252W mutation induced decreased Src family kinase tyrosine phosphorylation and activity associated with decreased Lyn and Fyn protein expression in human osteoblasts.	Tyrosine	85-93	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
15190072-8	2004	Transfection with c-Cbl in which the RING finger was disrupted or with c-Cbl with a point mutation that abolishes the binding ability of the Cbl phosphotyrosine-binding domain restored Src kinase activity and Lyn, Fyn, and FGFR2 levels and reduced ALP up-regulation in mutant osteoblasts.	Phosphotyrosine	145-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
15169900-5	2004	Upon TCR stimulation, ORF5 was efficiently tyrosine phosphorylated and subsequently interacted with cellular SH2-containing signaling proteins Lck, Fyn, SLP-76, and p85 through its tyrosine residues.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
15169900-5	2004	Upon TCR stimulation, ORF5 was efficiently tyrosine phosphorylated and subsequently interacted with cellular SH2-containing signaling proteins Lck, Fyn, SLP-76, and p85 through its tyrosine residues.	Tyrosine	181-189	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
15004239-9	2004	Last, using Src-family pharmacological inhibitors and dominant-negative Src, we showed that a Src-like kinase was required for tyrosine phosphorylation of Sprouty2 by growth factors.	Tyrosine	127-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	12-15
15004239-9	2004	Last, using Src-family pharmacological inhibitors and dominant-negative Src, we showed that a Src-like kinase was required for tyrosine phosphorylation of Sprouty2 by growth factors.	Tyrosine	127-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
15004239-9	2004	Last, using Src-family pharmacological inhibitors and dominant-negative Src, we showed that a Src-like kinase was required for tyrosine phosphorylation of Sprouty2 by growth factors.	Tyrosine	127-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-109
14761972-8	2004	This epidermal growth factor-induced tyrosine phosphorylation of TRPC6 was significantly blocked by PP2, a specific inhibitor of Src family PTKs, and by a dominant negative form of Fyn, suggesting that the direct phosphorylation of TRPC6 by Src family PTKs could be caused by physiological stimulation.	Tyrosine	37-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	181-184
14761972-9	2004	Furthermore, using single channel recording, we showed that Fyn modulates TRPC6 channel activity via tyrosine phosphorylation.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
14761972-4	2004	We found that TRPC6 is tyrosine-phosphorylated in COS-7 cells when coexpressed with Fyn, a member of the Src family PTKs.	carbonyl sulfide	50-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	84-87
15044737-1	2004	We have used (15)N- and (2)H-NMR spin relaxation experiments to study the response of backbone and side-chain dynamics when a leucine or valine is substituted for a completely buried phenylalanine residue in the SH3 domain from the Fyn tyrosine kinase.	Leucine	126-133	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	232-235
15124906-7	2004	p56lck, p59fyn and p53/56lyn are mediators of caspase-3 activation during Cr(III) exposure.	tris(1,10-phenanthroline)chromium(III) chloride	74-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-14
15124906-8	2004	Collectively, our findings support a plausible mechanism in which Cr(III) mediates ROS generation that precedes the up-regulation of p56lck, p59fyn and p53/56lyn which eventually activates caspase-3 to promote apoptotic cell death of lymphocytes.	tris(1,10-phenanthroline)chromium(III) chloride	66-73	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-147
15044737-1	2004	We have used (15)N- and (2)H-NMR spin relaxation experiments to study the response of backbone and side-chain dynamics when a leucine or valine is substituted for a completely buried phenylalanine residue in the SH3 domain from the Fyn tyrosine kinase.	Valine	137-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	232-235
14675807-2	2003	METHODS: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples.	Alcohols	83-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
14993658-5	2004	Mutational analysis confirmed that the polyproline motif responsible for binding to Grb2 also bound to the SH3 domains of Hck, Lck, Lyn and Fyn.	polyproline	39-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	140-143
14660555-2	2004	Most Src family kinases contain an N-terminal Met-Gly-Cys consensus sequence that undergoes dual acylation with myristate and palmitate after removal of methionine.	Met-Gly-Cys	46-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
14660555-2	2004	Most Src family kinases contain an N-terminal Met-Gly-Cys consensus sequence that undergoes dual acylation with myristate and palmitate after removal of methionine.	myristate and palmitate	112-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
14660555-2	2004	Most Src family kinases contain an N-terminal Met-Gly-Cys consensus sequence that undergoes dual acylation with myristate and palmitate after removal of methionine.	Methionine	153-163	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-8
14660555-3	2004	Previous studies of Src family kinase fatty acylation have relied on radiolabeling of cells with radioactive fatty acids.	radioactive fatty acids	97-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
14660555-7	2004	Furthermore, we show for the first time that Fyn is trimethylated at lysine residues 7 and/or 9 within its N-terminal region.	Lysine	69-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
14660555-10	2004	Lysine mutants of Fyn that could not be methylated failed to promote cell adhesion and spreading, suggesting that methylation is important for Fyn function.	Lysine	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
14660555-10	2004	Lysine mutants of Fyn that could not be methylated failed to promote cell adhesion and spreading, suggesting that methylation is important for Fyn function.	Lysine	0-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
14672668-5	2004	The motion of the conserved Trp depends on the presence of certain residues located in a key position (132 for Fyn), near the binding pocket.	Tryptophan	28-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	111-114
14675807-1	2003	BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice.	Alcohols	80-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	235-238
12721299-3	2003	This interaction involves phosphorylation of PKCdelta on tyrosine and is specific in that other isoforms of PKC, PKCepsilon and lambda, which also become tyrosine-phosphorylated, do not interact with Fyn.	Tyrosine	57-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	200-203
12902192-7	2003	Instead, Fyn and Lck were activated in A549 cells, indicating activation of specific Src family kinases in response to Cr(VI).	Chromium	119-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	9-12
12721299-3	2003	This interaction involves phosphorylation of PKCdelta on tyrosine and is specific in that other isoforms of PKC, PKCepsilon and lambda, which also become tyrosine-phosphorylated, do not interact with Fyn.	Tyrosine	154-162	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	200-203
12810359-0	2003	Dopamine inhibits cytokine release and expression of tyrosine kinases, Lck and Fyn in activated T cells.	Dopamine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
12721299-5	2003	Stimulation also leads to activation of both Fyn and PKCdelta and to serine phosphorylation of Fyn within a PKC consensus sequence.	Serine	69-75	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
12721299-6	2003	Alboaggregin-A-dependent activation of Fyn is blocked by bisindolylmaleimide I, suggesting a role for PKC isoforms in regulating Fyn activity.	bisindolylmaleimide	57-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
12721299-8	2003	Translocation of Fyn and PKCdelta are blocked by PP1 and bisindolylmaleimide I, showing a dependence upon Src and PKC kinase activities.	bisindolylmaleimide	57-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
12810359-4	2003	Dopamine suppressed non-receptor tyrosine kinases, Lck and Fyn expression which are the initial and pivotal signaling steps in T cell receptor (TCR) mediated different down stream signaling cascades, leading to cytokine release and subsequent clonal expansion of these immune effector cells.	Dopamine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
12788081-4	2003	p250GAP is tyrosine phosphorylated by Fyn when co-expressed in HEK293T cells.	Tyrosine	11-19	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
12788081-8	2003	Tyrosine phosphorylation of p250GAP by Fyn would regulate its RhoGAP activity, subcellular localization, or interactions with other proteins, leading to morphological and phenotypic changes of oligodendrocytes.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
12451687-0	2002	[Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation].	Tyrosine	54-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
12736333-0	2003	Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol.	Ethanol	86-93	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
12736333-4	2003	We report here that the brain region-specific compartmentalization of Fyn kinase determines NMDA receptor sensitivity to ethanol.	Ethanol	121-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
12736333-6	2003	During acute exposure to ethanol, RACK1 is dissociated from the complex, thereby facilitating Fyn-mediated phosphorylation of NR2B, which enhances channel activity, counteracting the inhibitory actions of ethanol.	Ethanol	25-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
12736333-6	2003	During acute exposure to ethanol, RACK1 is dissociated from the complex, thereby facilitating Fyn-mediated phosphorylation of NR2B, which enhances channel activity, counteracting the inhibitory actions of ethanol.	Ethanol	205-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
12871380-9	2003	The activity of the kinases that phosphorylate the Fc receptor gamma-chain, Fyn and Lyn, as well as the tyrosine kinase Syk and phosphoinositide 3-kinase was also inhibited by quercetin in a concentration-dependent manner, both in whole cells and in isolation.	Quercetin	176-185	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
12426371-5	2002	NMR analysis shows that the Fyn but not the Lck tyrosine kinase SH3 domain competes with CD2BP2 GYF-domain binding to the same CD2 proline-rich sequence in vitro.	Proline	131-138	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
12426371-6	2002	To test the in vivo significance of this competition, we used co-immunoprecipitation experiments and found that CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.	Proline	158-165	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	255-258
12558988-5	2003	The inclusion of boxes 6,7 was associated with a significant decrease in the binding of FAK+ to the c-Src and Fyn SH3 domains, and a significant increase in the binding to the Src SH2 domain, as a consequence of the higher phosphorylation of Tyr-397.	Tyrosine	242-245	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
12171928-7	2002	Mutational analysis revealed that tyrosine 271 in SKAP55 played a pivotal role for interaction with both Fyn kinase and adapter protein Grb-2, indicating that the Fyn-phosphorylated SKAP55 transiently associates with adapter Grb-2 to mediate mitogen-activated protein kinase activation.	Tyrosine	34-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
12171928-7	2002	Mutational analysis revealed that tyrosine 271 in SKAP55 played a pivotal role for interaction with both Fyn kinase and adapter protein Grb-2, indicating that the Fyn-phosphorylated SKAP55 transiently associates with adapter Grb-2 to mediate mitogen-activated protein kinase activation.	Tyrosine	34-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	163-166
11983687-0	2002	Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.	Phosphotyrosine	57-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
11983687-4	2002	By using human embryonic kidney 293 cells for co-transfection, we determined that a substrate-trapping variant (STEP(61) CS) binds to Fyn but not to other members of the Src family present in PSDs.	Cesium	121-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	134-137
11983687-4	2002	By using human embryonic kidney 293 cells for co-transfection, we determined that a substrate-trapping variant (STEP(61) CS) binds to Fyn but not to other members of the Src family present in PSDs.	Cesium	121-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	170-173
11983687-7	2002	STEP(61) CS pulls down Fyn when the Tyr(420) site is phosphorylated.	Cesium	9-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-26
11983687-7	2002	STEP(61) CS pulls down Fyn when the Tyr(420) site is phosphorylated.	Tyrosine	36-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-26
11983687-8	2002	In vitro, wild-type STEP(61) dephosphorylates Fyn at Tyr(420) but not at Tyr(531).	Tyrosine	53-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
11983687-9	2002	These results suggest that STEP regulates the activity of Fyn by specifically dephosphorylating the regulatory Tyr(420) and may be one mechanism by which Fyn activity is decreased within PSDs.	Tyrosine	111-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
11983687-9	2002	These results suggest that STEP regulates the activity of Fyn by specifically dephosphorylating the regulatory Tyr(420) and may be one mechanism by which Fyn activity is decreased within PSDs.	Tyrosine	111-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	154-157
11806999-4	2002	The Src-like kinases Lck and Fyn phosphorylate tyrosine residues in the cytoplasmic tail of CD150.	Tyrosine	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
12097497-2	2002	Here we show that in cortical neurons, brief selective activation of group I mGluRs with (S)-3,5-dihydroxy-phenylglycine (DHPG) induced a Ca(2+)-calmodulin-dependent activation of Pyk2/CAKbeta and the Src-family kinases Src and Fyn that was independent of protein kinase C (PKC).	3,5-dihydroxyphenylglycine	89-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	228-231
11943772-0	2002	Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling.	Proline	36-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
11943772-2	2002	Molecular cloning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic tail which has the consensus for interaction with the Src homology 3 (SH3) domains of Fyn and Lyn.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	199-202
11943772-4	2002	Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR gamma-chain in transiently transfected COS-7 cells, but did not affect the association of the gamma-chain with GPVI.	Proline	30-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
11943772-7	2002	These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI.	Proline	36-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
12097497-2	2002	Here we show that in cortical neurons, brief selective activation of group I mGluRs with (S)-3,5-dihydroxy-phenylglycine (DHPG) induced a Ca(2+)-calmodulin-dependent activation of Pyk2/CAKbeta and the Src-family kinases Src and Fyn that was independent of protein kinase C (PKC).	3,5-dihydroxyphenylglycine	122-126	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	228-231
12097497-3	2002	Activation of Pyk2 and Src/Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B (NR2A/B) and was blocked by a selective mGluR1 antagonist, 7-(hydroxyamino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, but not an mGluR5 antagonist, 2-methyl-6-(phenylethynyl)pyridine.	Tyrosine	56-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
12097497-3	2002	Activation of Pyk2 and Src/Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B (NR2A/B) and was blocked by a selective mGluR1 antagonist, 7-(hydroxyamino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, but not an mGluR5 antagonist, 2-methyl-6-(phenylethynyl)pyridine.	7-(hydroxyamino)cyclopropa[b]chromen-1a-carboxylate ethyl ester	175-238	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
12097497-3	2002	Activation of Pyk2 and Src/Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B (NR2A/B) and was blocked by a selective mGluR1 antagonist, 7-(hydroxyamino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, but not an mGluR5 antagonist, 2-methyl-6-(phenylethynyl)pyridine.	6-methyl-2-(phenylethynyl)pyridine	270-304	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
11970992-4	2002	Furthermore, FcR nonbinding anti-CD3 mAbs induced tyrosine phosphorylation of the Fyn substrate Cbl, but not the ZAP-70 substrate linker for activation of T cells.	Tyrosine	50-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
11909961-6	2002	Furthermore, overexpression of SKAP55-Y232F also caused the tyrosine hyperphosphorylation of Fyn with a decreased kinase activity.	Tyrosine	60-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-96
11594778-5	2001	A synthetic peptide corresponding to the amino-terminal region encompassing tyrosine 100 of NMT served as a good substrate for the Lyn and Fyn kinases.	Tyrosine	76-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-142
11546790-8	2001	Co-transfections with MAP-2c and the extracellular signal-regulated kinase 2 (ERK2) demonstrated that MAP-2c is threonine/serine-phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn binding.	Threonine	112-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
11546790-8	2001	Co-transfections with MAP-2c and the extracellular signal-regulated kinase 2 (ERK2) demonstrated that MAP-2c is threonine/serine-phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn binding.	Serine	122-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
11546790-8	2001	Co-transfections with MAP-2c and the extracellular signal-regulated kinase 2 (ERK2) demonstrated that MAP-2c is threonine/serine-phosphorylated on its RTPPKSP motif and that threonine phosphorylation abolished the MAP-2c/Fyn binding.	Threonine	174-183	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
11677266-0	2001	Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
11536198-0	2001	Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	43-46
11466305-6	2001	In permeabilized Jurkat T cells, GST-p59(fyn), but not GST-p56(lck), GST-Grb2, or GST alone, significantly and concentration-dependently enhanced Ca(2+) release by cyclic ADP-ribose.	Cyclic ADP-Ribose	164-181	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
11565612-3	2001	The src family kinase-selective inhibitor PP1 reduced carbachol-stimulated tyrosine phosphorylation of FAK, Cas, and paxillin by 50 to 75%.	Carbachol	54-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
11531019-9	2001	Finally, our data suggested that the inhibition of intestinal T cell proliferation could result via PGE2-mediated down-regulation of the T cell activation-signaling molecule P59fyn.	Dinoprostone	100-104	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	174-180
11526478-4	2001	Fyn cleavage occurred in Fas-stimulated Jurkat T cells but Fyn and Lyn were also processed in the SKW6.4 B cell line.	ammonium ferrous sulfate	25-28	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11526478-5	2001	Inhibition of caspases by Z-VAD-fmk or Ac-DEVD-CHO totally prevented Fyn and Lyn cleavage in both intact cells and in vitro.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	26-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
11526478-5	2001	Inhibition of caspases by Z-VAD-fmk or Ac-DEVD-CHO totally prevented Fyn and Lyn cleavage in both intact cells and in vitro.	acetyl-aspartyl-glutamyl-valyl-aspartal	39-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
11526478-7	2001	Single mutation of Asp 19 or Asp 18 in the unique N-terminal domains of Fyn and Lyn respectively abolished their cleavage and relocation into the cytoplasm of apoptotic cells.	Aspartic Acid	29-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
11369760-6	2001	CD44-mediated cell spreading and induced tyrosine phosphorylation were prevented by the Src family kinase inhibitor, PP2.	Tyrosine	41-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-91
11423543-0	2001	Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.	Fatty Acids, Unsaturated	57-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
11423543-3	2001	The ability of unsaturated dietary fatty acids to be attached to Src family kinases has not been investigated.	unsaturated dietary fatty acids	15-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
11423543-4	2001	Here we demonstrate that heterogeneous fatty acylation of Src family kinases occurs and that the nature of the attached fatty acid influences raft-mediated signal transduction.	Fatty Acids	120-130	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
11423543-5	2001	By using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we show that in addition to 14:0 (myristate), 14:1 and 14:2 fatty acids can be attached to the N-terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids.	Fatty Acids	147-158	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	208-211
11423543-5	2001	By using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we show that in addition to 14:0 (myristate), 14:1 and 14:2 fatty acids can be attached to the N-terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids.	Fatty Acids	147-158	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	226-229
11423543-5	2001	By using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we show that in addition to 14:0 (myristate), 14:1 and 14:2 fatty acids can be attached to the N-terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids.	Glycine	193-200	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	208-211
11423543-5	2001	By using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we show that in addition to 14:0 (myristate), 14:1 and 14:2 fatty acids can be attached to the N-terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids.	Glycine	193-200	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	226-229
11423543-5	2001	By using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we show that in addition to 14:0 (myristate), 14:1 and 14:2 fatty acids can be attached to the N-terminal glycine of the Src family kinase Fyn when the growth media are supplemented with these dietary fatty acids.	Fatty Acids	288-299	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	208-211
11423543-6	2001	Moreover, we synthesized novel iodinated analogs of oleate and stearate, and we showed that heterogeneous S-acylation can occur on cysteine residues within Fyn as well as Galpha, GAP43, and Ras.	Cysteine	131-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	156-159
11423543-7	2001	Modification of Fyn with unsaturated or polyunsaturated fatty acids reduced its raft localization and resulted in decreased T cell signal transduction.	unsaturated or	25-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
11423543-7	2001	Modification of Fyn with unsaturated or polyunsaturated fatty acids reduced its raft localization and resulted in decreased T cell signal transduction.	Fatty Acids, Unsaturated	40-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
11483655-2	2001	We have investigated the tyrosine phosphorylation of NMDA receptor subunits NR2A and NR2B by exogenous Src and Fyn and compared this to phosphorylation by tyrosine kinases associated with the postsynaptic density (PSD).	Tyrosine	25-33	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	111-114
11565612-6	2001	Site-specific FAK phosphotyrosine antibodies were used to determine that the carbachol-stimulated increase in the autophosphorylation of FAK was unaffected by pretreatment with PP1, whereas the carbachol-stimulated increase in the src family kinase-mediated phosphotyrosine of FAK was completely blocked by pretreatment with PP1.	Carbachol	77-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
11565612-7	2001	In SH-SY5Y cell lines stably overexpressing Fyn, the phosphotyrosine immunoreactivity of FAK was 625% that of control cells.	Phosphotyrosine	53-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	44-47
11565612-8	2001	Thus, muscarinic receptors activate protein tyrosine phosphorylation in differentiated cells, and the tyrosine phosphorylation of FAK, Cas, and paxillin, but not ERK1/2, is mediated by a src family tyrosine kinase activated in response to stimulation of muscarinic receptors.	Tyrosine	102-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	187-190
11565612-3	2001	The src family kinase-selective inhibitor PP1 reduced carbachol-stimulated tyrosine phosphorylation of FAK, Cas, and paxillin by 50 to 75%.	Tyrosine	75-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	32-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	32-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	80-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Carbachol	80-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Tyrosine	98-106	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Tyrosine	98-106	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-133
11565612-5	2001	Src family kinase activation by carbachol was further demonstrated by increased carbachol-induced tyrosine phosphorylation of the src-substrate, p120, and tyrosine phosphorylation of the src family kinase activation-associated autophosphorylation site.	Tyrosine	155-163	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11493667-3	2001	Both null cells for pp60(c-src) and triple knockout cells for pp60(c-src), pp59(fyn), and pp62(c-yes) exhibited decreased phosphotyrosine levels in focal contacts when compared with wild-type cells.	Phosphotyrosine	122-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
11056155-4	2001	Fyn constitutively associated with and phosphorylated Cas, suggesting that Cas tyrosine phosphorylation may be catalyzed by Fyn.	Tyrosine	79-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	124-127
11228160-7	2001	The CD44 initiated reorganization of the cytoskeleton was associated with the recruitment of CD44 and the associated tyrosine phosphokinases p56(lck) and p59(fyn) into glycolipid enriched membrane microdomains (GEM).	Glycolipids	168-178	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	158-161
11087735-10	2001	Finally, scrape loading cells with glutathione S-transferase fusion proteins of either the Fyn-SH2 or Fyn-SH3 domain significantly attenuated mAChR-stimulated ACK-1 tyrosine phosphorylation.	Glutathione	35-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	91-94
11087735-10	2001	Finally, scrape loading cells with glutathione S-transferase fusion proteins of either the Fyn-SH2 or Fyn-SH3 domain significantly attenuated mAChR-stimulated ACK-1 tyrosine phosphorylation.	Glutathione	35-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
11087735-10	2001	Finally, scrape loading cells with glutathione S-transferase fusion proteins of either the Fyn-SH2 or Fyn-SH3 domain significantly attenuated mAChR-stimulated ACK-1 tyrosine phosphorylation.	Tyrosine	165-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	91-94
11087735-10	2001	Finally, scrape loading cells with glutathione S-transferase fusion proteins of either the Fyn-SH2 or Fyn-SH3 domain significantly attenuated mAChR-stimulated ACK-1 tyrosine phosphorylation.	Tyrosine	165-173	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
11056155-4	2001	Fyn constitutively associated with and phosphorylated Cas, suggesting that Cas tyrosine phosphorylation may be catalyzed by Fyn.	Tyrosine	79-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
11121167-1	2000	Lack of Fyn tyrosine kinase increases alcohol sensitivity.	Alcohols	38-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-11
11058601-4	2001	Several lines of evidence implicate Fyn in the regulation of calcium mobilization, at least in part through the activation of phospholipase Cgamma.	Calcium	61-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
11036077-8	2001	These results indicate that CD146 is coupled to a FYN-dependent pathway that triggers Ca(2+) flux via phospholipase C-gamma activation leading subsequently to the tyrosine phosphorylation of downstream targets such as Pyk2, p130(Cas), FAK, and paxillin.	Tyrosine	163-171	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
11024032-5	2001	Of these 7 residues, Tyr-1252, Tyr-1336, and Tyr-1472 in GluR epsilon 2 were phosphorylated in human embryonic kidney fibroblasts when co-expressed with active Fyn, and Tyr-1472 was the major phosphorylation site in this system.	Tyrosine	21-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
11162638-0	2001	Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.	Tyrosine	48-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
11162638-5	2001	Mutation analysis revealed that activated Fyn phosphorylates specifically tyrosine residue 125 of alpha-synuclein.	Tyrosine	74-82	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
11237406-6	2001	The molecular weight, iso-electric point, efficient phosphorylation by fyn and lck and preferential binding to the SH2 domain of fyn compared to that of lck indicate that Thy-1-associated pp85-90 may be identical to a recently cloned, fyn-associated transmembrane adaptor protein, PAG-85.	phenylacetylglycine	281-284	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
11237406-6	2001	The molecular weight, iso-electric point, efficient phosphorylation by fyn and lck and preferential binding to the SH2 domain of fyn compared to that of lck indicate that Thy-1-associated pp85-90 may be identical to a recently cloned, fyn-associated transmembrane adaptor protein, PAG-85.	phenylacetylglycine	281-284	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
11119516-3	2001	Here, we show that the internalization of P. aeruginosa into human epithelial cells results in and requires activation of the Src-like tyrosine kinases p59Fyn and p60Src and the consequent tyrosine phosphorylation of several eukaryotic proteins.	Tyrosine	135-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-158
10921917-10	2000	Hypertonicity provoked Fyn-dependent tyrosine phosphorylation in beta-catenin, alpha-catenin, and p120(Cas) and caused the dissociation of beta-catenin from the contacts.	Tyrosine	37-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-26
10945993-6	2000	In response to PDGF, Fyn associated with PKCdelta via tyrosine 187.	Tyrosine	54-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
10945993-7	2000	Finally, overexpression of dominant negative Fyn abrogated the decrease in GS expression and reduced the tyrosine phosphorylation of PKCdelta induced by PDGF.	Tyrosine	105-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
10921917-3	2000	We have shown previously that shrinkage induces Fyn-dependent tyrosine phosphorylation of the cortical actin-binding protein, cortactin.	Tyrosine	62-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	48-51
10930415-5	2000	In this paper, we demonstrate that p64 becomes tyrosine phosphorylated when co-expressed with p59(fyn) in HeLa cells.	Tyrosine	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
10921917-10	2000	Hypertonicity provoked Fyn-dependent tyrosine phosphorylation in beta-catenin, alpha-catenin, and p120(Cas) and caused the dissociation of beta-catenin from the contacts.	Calcium	103-106	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-26
10808124-3	2000	Our previous study had shown that PLC-gamma, pp125FAK (focal adhesion kinase), pp105, paxillin, p59fyn, p56lck and ERK1/2 are phosphorylated in their tyrosine residues upon engagement of beta1-integrins.	Tyrosine	150-158	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-102
10871840-3	2000	Consistent with this finding, Grb10 tyrosine phosphorylation in cells was inhibited by herbimycin A, a relatively specific inhibitor for members of the Src tyrosine kinase family, and by the expression of dominant negative Src or Fyn.	Tyrosine	36-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	230-233
10871840-4	2000	In addition, Grb10 tyrosine phosphorylation was stimulated by expression of constitutively active Src or Fyn in cells and by incubation with purified Src or Fyn in vitro.	Tyrosine	19-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
10871840-4	2000	In addition, Grb10 tyrosine phosphorylation was stimulated by expression of constitutively active Src or Fyn in cells and by incubation with purified Src or Fyn in vitro.	Tyrosine	19-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	157-160
10871840-5	2000	The insulin stimulated or Src/Fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when Grb10 tyrosine 67 was changed to glycine.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
10871840-5	2000	The insulin stimulated or Src/Fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when Grb10 tyrosine 67 was changed to glycine.	Tyrosine	113-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
10871840-5	2000	The insulin stimulated or Src/Fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when Grb10 tyrosine 67 was changed to glycine.	Glycine	140-147	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
11005864-5	2000	Antagonist stimulation increased tyrosine phosphorylation and kinase activity of Fyn severalfold, whereas little or no increase in Lck and ZAP-70 activity was observed.	Tyrosine	33-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
11005864-6	2000	Second, TCR stimulation of Lck(-), Fyn(hi) Jurkat cells induced strong tyrosine phosphorylation of Vav.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	35-38
10934044-10	2000	Interestingly, both Pyk2 and FPhy2 (to a greater extent) were tyrosine phosphorylated and associated with Src and Fyn.	Tyrosine	62-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
10934044-11	2000	This suggested that they may inhibit Erk activation in an analogous manner as the mislocalized FAK mutant (&Dgr;)C14 described previously by competing with endogenous FAK for binding signaling molecules such as Src and Fyn.	Adenosine Monophosphate	108-111	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	223-226
10921884-5	2000	Kv2.1 associates with a substrate-trapping mutant of PTP epsilon, and PTP epsilon profoundly reduces Src- or Fyn-stimulated Kv2.1 currents and tyrosine phosphorylation in transfected HEK 293 cells.	Tyrosine	143-151	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
10838156-1	2000	Tyrosine kinases, c-Src and Fyn, in their active form, have their C-terminal tyrosine residue dephosphorylated.	Tyrosine	77-85	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
10809781-6	2000	Tyr phosphorylation of the L1 cytoplasmic tail and the Src kinase Fyn was observed following pervanadate treatment.	pervanadate	93-104	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
10809781-7	2000	Up-regulation of L1 release and activation of Fyn occurred also when cells were detached by EDTA suggesting that the regulation of L1 shedding by this pathway was linked to cell morphology and adhesion.	Edetic Acid	92-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
24383527-3	2000	Our previous study showed that PLC-gamma, pp125FAK (focal adhesion kinase), pp105, paxillin, p59fyn, p56lck, and ERK1/2 are phosphorylated in their tyrosine residues upon engagement of beta1 integrins.	Tyrosine	148-156	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	93-99
10648627-5	2000	Fyn was able to induce tyrosine phosphorylation of the TCR and recruitment of the ZAP-70 kinase, but the pattern of TCR phosphorylation was altered and activation of ZAP-70 was defective.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10640723-3	2000	Stimulation of T cells via the alpha4beta1 integrin enhances the association of tyrosine phosphorylated SLAP-130/FYB with the SH2 domain of the src tyrosine kinase p59fyn.	Tyrosine	80-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	164-170
10591186-4	1999	In addition, cross-linking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible.	Tyrosine	44-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Threonine	42-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	322-325
10551884-9	1999	The significance of these data is that Jak2, in addition to serving as a critical angiotensin II activated signal transduction kinase, also functions as a docking protein and participates in the activation of Fyn by providing phosphotyrosine residues that bind the SH2 domain of Fyn.	Phosphotyrosine	226-241	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	209-212
10551884-9	1999	The significance of these data is that Jak2, in addition to serving as a critical angiotensin II activated signal transduction kinase, also functions as a docking protein and participates in the activation of Fyn by providing phosphotyrosine residues that bind the SH2 domain of Fyn.	Phosphotyrosine	226-241	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	279-282
10611930-5	1999	We have also investigated the localization of the src family that is involved in tyrosine phosphorylation signaling in Hassall"s corpuscles.	Tyrosine	81-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
10617614-2	2000	Here we identify a palmitate analog, 2-bromopalmitate, that effectively blocks Fyn fatty acylation in general and palmitoylation in particular.	Palmitates	19-28	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10617614-2	2000	Here we identify a palmitate analog, 2-bromopalmitate, that effectively blocks Fyn fatty acylation in general and palmitoylation in particular.	2-bromopalmitate	37-53	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Fatty Acids, Unsaturated	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Fatty Acids, Unsaturated	22-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Arachidonic Acid	28-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Arachidonic Acid	28-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Eicosapentaenoic Acid	49-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10617614-8	2000	Here we show that the PUFAs arachidonic acid and eicosapentaenoic acid inhibit Fyn palmitoylation and consequently block Fyn localization to DRMs.	Eicosapentaenoic Acid	49-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Proline	4-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	322-325
10601992-1	1999	The proline-, glutamic acid-, serine- and threonine-enriched protein tyrosine phosphatase PEP, which is expressed primarily in hematopoietic cells, was recently discovered to be physically associated with the 50-kDa cytosolic protein tyrosine kinase (PTK) Csk, an important suppressor of Src family PTK, including Lck and Fyn in T cells.	Serine	30-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	322-325
10528214-3	1999	While ERK activation is rapid and transient, peaking at 10 min, the JNK1 activation is delayed and more sustained reaching a maximum at 2 h. ERK activation was blocked by CP 118556, indicating it is regulated by a Src-like kinase, while JNK1 was inhibited by piceatannol, revealing an upstream regulation by Syk.	3,3',4,5'-tetrahydroxystilbene	259-270	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-229
10609783-6	1999	The Src-family non-receptor PTKs such as Lck, Fyn, Lyn and Hck were shown to be coupled to CD44 via sphingolipid-rich microdomains (lipid rafts) of the plasma membrane.	Sphingolipids	100-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
10609783-6	1999	The Src-family non-receptor PTKs such as Lck, Fyn, Lyn and Hck were shown to be coupled to CD44 via sphingolipid-rich microdomains (lipid rafts) of the plasma membrane.	Sphingolipids	100-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
10532312-5	1999	We find that the kinase activity of Fyn is stimulated as a result of binding to WASP, and that a cellular protein, which may be WASP itself, becomes phosphorylated on tyrosine as a result of the binding of WASP to Fyn.	Tyrosine	167-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
10506155-0	1999	Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination.	Glycosylphosphatidylinositols	36-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	20-23
14634336-5	1999	While crosslinking of Fas affected the association of p59fyn and p56lck tyrosine kinases with the TCR zeta chain to a limited degree, it dramatically inhibited the association of the protein tyrosine kinase ZAP70 with the zeta chain.	ammonium ferrous sulfate	22-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-60
10548041-9	1999	Under the nanoflow ESI conditions, water molecules appear to be maintained in the Fyn SH2-ligand complex.	Water	35-40	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
10498895-0	1999	Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.	Tyrosine	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
10498895-0	1999	Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.	Tyrosine	86-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
10498895-6	1999	In vitro binding experiments revealed that phosphorylation at Tyr-615 in EphA8 mediates the preferential binding to Fyn-SH2 domain rather than Src and Ras GTPase-activating protein (Ras GAP)-SH2 domains.	Tyrosine	62-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
10498895-8	1999	In contrast, the association of full-length Fyn to EphA8 containing mutation at either Tyr-615 or Tyr-838 was greatly reduced.	Tyrosine	87-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	44-47
10498895-8	1999	In contrast, the association of full-length Fyn to EphA8 containing mutation at either Tyr-615 or Tyr-838 was greatly reduced.	Tyrosine	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	44-47
10498895-9	1999	These data indicate that phosphorylation of Tyr-615 is critical for determining the association with Fyn whereas the integrity of Tyr-838 phosphorylation is required for efficient phosphorylation at Tyr-615 as well as other major sites.	Tyrosine	44-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	101-104
10498895-12	1999	We therefore propose that Fyn kinase is one of the major downstream targets for the EphA8 signaling pathway leading to a modification of cell adhesion, and that autophosphorylation at Tyr-838 is critical for positively regulating the EphA8 signaling event.	Tyrosine	184-187	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-29
10477689-7	1999	The Src family-specific inhibitor PP1 dose-dependently inhibits phosphorylation of Syk, its association with tyrosine-phosphorylated gamma-chain, phosphorylation of PLCgamma2, platelet aggregation, and 5-HT release.	Tyrosine	109-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
10553579-4	1999	Non-receptor type tyrosine kinase Fyn in the Src family has been suggested to promote kindling development via tyrosine phosphorylation of the NMDA-receptor subunit, NR2B.	Tyrosine	18-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
10553579-4	1999	Non-receptor type tyrosine kinase Fyn in the Src family has been suggested to promote kindling development via tyrosine phosphorylation of the NMDA-receptor subunit, NR2B.	Tyrosine	18-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
10430626-5	1999	Here we demonstrate that Lck and Fyn can be activated by proline motifs in the CD28 and CD2 proteins, respectively.	Proline	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
10458777-4	1999	Using the phosphotyrosine binding domains of the Shc adaptor and the Fyn kinase, which both participate in CD4 signaling, as baits, we show that CD4 induces tyrosine phosphorylation of a subset of the proteins phosphorylated in response to TCR/CD3 engagement.	Tyrosine	17-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
10532312-5	1999	We find that the kinase activity of Fyn is stimulated as a result of binding to WASP, and that a cellular protein, which may be WASP itself, becomes phosphorylated on tyrosine as a result of the binding of WASP to Fyn.	Tyrosine	167-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	214-217
10383400-3	1999	Further indications of direct interaction are that p59fyn potentiates thetaPKC catalytic activity and that thetaPKC is a substrate for tyrosine phosphorylation by p59fyn.	Tyrosine	135-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-57
10409671-0	1999	FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells.	Tyrosine	73-81	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10435619-0	1999	Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.	ammonium ferrous sulfate	61-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-53
10435619-2	1999	We report here the identification of the tyrosine kinase p59Fyn as a substrate for CPP32-like proteinases and more particularly caspase 3 during Fas-mediated apoptosis in Jurkat T cells.	ammonium ferrous sulfate	145-148	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-63
10435619-3	1999	Inhibition of CPP32-like proteinases by Ac-Asp-Glu-Val-Asp-aldehyde but not by Ac-Tyr-Val-Ala-Asp-aldehyde prevents CPP32, PARP and p59Fyn cleavage indicating that CPP32 or CPP32-like proteinases are responsible for the cleavage of p59Fyn.	acetyl-aspartyl-glutamyl-valyl-aspartal	40-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	132-138
10383400-3	1999	Further indications of direct interaction are that p59fyn potentiates thetaPKC catalytic activity and that thetaPKC is a substrate for tyrosine phosphorylation by p59fyn.	Tyrosine	135-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	163-169
10086316-0	1999	Molecular mechanisms of Fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity.	Ethanol	83-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
10209031-0	1999	Dual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions.	Phosphotyrosine	105-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
10358169-0	1999	Fyn membrane localization is necessary to induce the constitutive tyrosine phosphorylation of Sam68 in the nucleus of T lymphocytes.	Tyrosine	66-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10342851-6	1999	Moreover, although the endometrial stromal cells expressed another src-family kinase, Fyn, the activity of the Fyn kinase was almost undetectable during decidualization and thereafter upon steroid withdrawal.	Steroids	189-196	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	111-114
10209031-1	1999	The first 10 residues within the Src homology domain (SH)-4 domain of the Src family kinase Fyn are required for binding to the immune receptor tyrosine-based activation motif (ITAM) of T cell receptor (TCR) subunits.	Tyrosine	144-152	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
10209031-1	1999	The first 10 residues within the Src homology domain (SH)-4 domain of the Src family kinase Fyn are required for binding to the immune receptor tyrosine-based activation motif (ITAM) of T cell receptor (TCR) subunits.	Tyrosine	144-152	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	92-95
10209031-2	1999	Recently, mutation of glycine 2, cysteine 3, and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs, prompting the designation of these residues as an ITAM recognition motif (Gauen, L.K.T., M.E.	Glycine	22-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
10209031-2	1999	Recently, mutation of glycine 2, cysteine 3, and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs, prompting the designation of these residues as an ITAM recognition motif (Gauen, L.K.T., M.E.	Cysteine	33-41	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
10209031-2	1999	Recently, mutation of glycine 2, cysteine 3, and lysines 7 and 9 was shown to block binding of Fyn to TCR zeta chain ITAMs, prompting the designation of these residues as an ITAM recognition motif (Gauen, L.K.T., M.E.	Lysine	49-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
10209031-10	1999	Conversely, treatment of cells with 2-hydroxymyristate, a myristoylation inhibitor, blocked association of wild-type Fyn with zeta.	alpha-hydroxymyristic acid	36-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	117-120
10209031-11	1999	The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.	Tyrosine	170-179	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
10209031-11	1999	The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.	Tyrosine	170-179	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-92
10086316-1	1999	Mice lacking Fyn, a Src-related non-receptor tyrosine kinase, show impairment of various behaviors, such as spatial learning, suckling, emotional behaviors, and ethanol sensitivity.	Ethanol	161-168	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
10209031-11	1999	The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.	Phosphotyrosine	205-221	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
10086316-6	1999	Regarding the glutamatergic defect, in particular, after ethanol administration the N-methyl-D-aspartate (NMDA)-dependent function is recovered by Fyn, paralleled with tyrosine phosphorylation of NMDA receptor 2B subtype.	Ethanol	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	147-150
10209031-11	1999	The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.	Phosphotyrosine	205-221	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-92
10209031-14	1999	We conclude that the Fyn SH4 domain provides the signals for fatty acylation and specific plasma membrane localization, stabilizing the interactions between the Fyn SH2 domain and phosphotyrosines in TCR zeta chain ITAMs.	Phosphotyrosine	180-196	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
10209031-14	1999	We conclude that the Fyn SH4 domain provides the signals for fatty acylation and specific plasma membrane localization, stabilizing the interactions between the Fyn SH2 domain and phosphotyrosines in TCR zeta chain ITAMs.	Phosphotyrosine	180-196	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-164
10086316-6	1999	Regarding the glutamatergic defect, in particular, after ethanol administration the N-methyl-D-aspartate (NMDA)-dependent function is recovered by Fyn, paralleled with tyrosine phosphorylation of NMDA receptor 2B subtype.	N-Methylaspartate	84-104	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	147-150
10086316-6	1999	Regarding the glutamatergic defect, in particular, after ethanol administration the N-methyl-D-aspartate (NMDA)-dependent function is recovered by Fyn, paralleled with tyrosine phosphorylation of NMDA receptor 2B subtype.	N-Methylaspartate	106-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	147-150
10098840-0	1999	Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells.	Ethanol	32-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10098840-4	1999	In this study, the effects of Fyn tyrosine kinase on the ethanol sensitivity of specific recombinant NMDA receptors expressed in HEK 293 cells were investigated.	Ethanol	57-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
10098840-6	1999	In contrast, the inhibition of NR1/NR2A receptors by ethanol (100 mM) was significantly reduced under conditions of enhanced Fyn-mediated tyrosine phosphorylation of the NR2A subunit.	Ethanol	53-60	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	125-128
10098840-6	1999	In contrast, the inhibition of NR1/NR2A receptors by ethanol (100 mM) was significantly reduced under conditions of enhanced Fyn-mediated tyrosine phosphorylation of the NR2A subunit.	Tyrosine	138-146	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	125-128
10098840-8	1999	These results suggest that tyrosine phosphorylation of specific NMDA receptors by Fyn tyrosine kinase may regulate the sensitivity of these receptors to the sedative/hypnotic concentrations of ethanol.	Tyrosine	27-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
10098840-8	1999	These results suggest that tyrosine phosphorylation of specific NMDA receptors by Fyn tyrosine kinase may regulate the sensitivity of these receptors to the sedative/hypnotic concentrations of ethanol.	Ethanol	193-200	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
10198045-1	1999	Src family protein-tyrosine kinases are implicated in signaling via glycosylphosphatidylinositol (GPI)-anchored receptors.	Glycosylphosphatidylinositols	68-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10229084-3	1999	Among the individual members of the Fyn-complex pp85, SKAP55 and pp43 are constitutively phosphorylated on tyrosine residue(s) in vivo and likely interact with Fyn via its src homology 2 (SH2)-domain.	Tyrosine	107-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
10229084-3	1999	Among the individual members of the Fyn-complex pp85, SKAP55 and pp43 are constitutively phosphorylated on tyrosine residue(s) in vivo and likely interact with Fyn via its src homology 2 (SH2)-domain.	Tyrosine	107-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-163
10198045-1	1999	Src family protein-tyrosine kinases are implicated in signaling via glycosylphosphatidylinositol (GPI)-anchored receptors.	Glycosylphosphatidylinositols	98-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
10198045-7	1999	We propose that in lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.	Glycosylphosphatidylinositols	116-119	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
10198045-7	1999	We propose that in lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.	Sphingolipids	125-137	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
10198045-7	1999	We propose that in lymphocyte plasma membranes, Lck and Fyn kinases exhibit optimal activity when juxtaposed to the GPI- and sphingolipid-enriched core microdomains but encounter inhibitory conditions in surrounding membrane areas that are rich in glycerophospholipids and contain additional transmembrane proteins.	Glycerophospholipids	248-268	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
10326252-1	1999	The stability and folding thermodynamics of two SH3-domains, belonging to Fyn and Abl proteins, have been studied by scanning calorimetry and urea-induced unfolding.	Urea	142-146	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	74-77
10085136-6	1999	Src family tyrosine kinases resulted in CADTK tyrosine phosphorylation even when co-expressed with the Tyr402/Tyr881 double mutant, suggesting that Src/Fyn etc.	Tyrosine	11-19	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-155
10026222-6	1999	Tyrosine phosphorylation of all of these proteins in the in vitro kinase assay was abrogated by the Src family kinase inhibitor PP1, suggesting that it is mediated by either Fyn or Lyn.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
10217203-6	1999	In this study we have analyzed the ability of src family tyrosine kinases and the CD45 tyrosine phosphatase in determining the phosphorylation state of the different ITAMs and the individual tyrosine residues of the TCR zeta chain.	Tyrosine	57-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
10026222-6	1999	Tyrosine phosphorylation of all of these proteins in the in vitro kinase assay was abrogated by the Src family kinase inhibitor PP1, suggesting that it is mediated by either Fyn or Lyn.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	174-177
9973379-4	1999	In this report, we show that CTLA-4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck, but not the unrelated kinase ZAP70, can induce tyrosine phosphorylation of CTLA-4 on residues Y201 and Y218.	Tyrosine	167-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
10706243-9	1999	We found that only immunotoxic PAHs activated the Fyn and ZAP-70 PTKs at 10 min, but total PTK activity was still increased by nonimmunotoxic PAHs, BeP, or anthracene after 10 min of exposure.	Polycyclic Aromatic Hydrocarbons	31-35	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
9931317-6	1999	After stimulation by CRP or collagen, the Src-family kinases p59fyn and p53/56lyn became associated with several tyrosine-phosphorylated proteins including the FcR gamma chain.	Tyrosine	113-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
9931317-6	1999	After stimulation by CRP or collagen, the Src-family kinases p59fyn and p53/56lyn became associated with several tyrosine-phosphorylated proteins including the FcR gamma chain.	Tyrosine	113-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-67
9712039-3	1998	In the membrane fraction, tyrosine phosphorylation of Lck, Fyn, and CD3 zeta can be induced by PTP inhibitors, but not by anti-CD3.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
9930729-4	1999	The increase in GSK-3beta tyrosine phosphorylation corresponded directly to an increase in the association of Fyn tyrosine kinase with GSK-3beta, and Fyn immunoprecipitated from cells treated with insulin for 1 min phosphorylated GSK-3beta to a significantly greater extent than Fyn immunoprecipitated from control cells.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
9930729-4	1999	The increase in GSK-3beta tyrosine phosphorylation corresponded directly to an increase in the association of Fyn tyrosine kinase with GSK-3beta, and Fyn immunoprecipitated from cells treated with insulin for 1 min phosphorylated GSK-3beta to a significantly greater extent than Fyn immunoprecipitated from control cells.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
9930729-4	1999	The increase in GSK-3beta tyrosine phosphorylation corresponded directly to an increase in the association of Fyn tyrosine kinase with GSK-3beta, and Fyn immunoprecipitated from cells treated with insulin for 1 min phosphorylated GSK-3beta to a significantly greater extent than Fyn immunoprecipitated from control cells.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
9892651-0	1999	PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.	Tyrosine	29-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
9892651-4	1999	NR2A was tyrosine-phosphorylated in 293T cells when coexpressed with Fyn.	Tyrosine	9-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-72
9892651-6	1999	Results also showed that PSD-95, which directly binds to and coclusters with NMDA receptors, promotes Fyn-mediated tyrosine phosphorylation of NR2A.	Tyrosine	115-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
9819209-1	1998	The SH3 domain from the Fyn tyrosine kinase possesses a buried hydrogen bond between the side chains of a glutamate (Glu24) and a serine (Ser41) residue.	Hydrogen	63-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
9819209-1	1998	The SH3 domain from the Fyn tyrosine kinase possesses a buried hydrogen bond between the side chains of a glutamate (Glu24) and a serine (Ser41) residue.	Glutamic Acid	106-115	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
9819209-1	1998	The SH3 domain from the Fyn tyrosine kinase possesses a buried hydrogen bond between the side chains of a glutamate (Glu24) and a serine (Ser41) residue.	Serine	130-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
9804857-0	1998	Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by Janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	149-152
9804857-5	1998	Rather, p59 Fyn functions as an Ang II-activated docking protein for both JAK2 and STAT1, a docking interaction that may facilitate JAK2-mediated STAT1 tyrosine phosphorylation.	Tyrosine	152-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	8-15
9763511-5	1998	Here we report that a proline rich sequence in the amino terminus of tau interacts with the SH3 domains of fyn and src non-receptor tyrosine kinases.	Proline	22-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
9763511-8	1998	Fyn-dependent tyrosine phosphorylation of tau occurred in transfected cells and tyrosine phosphorylated tau was identified in human neuroblastoma cells as well.	Tyrosine	14-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
9763511-8	1998	Fyn-dependent tyrosine phosphorylation of tau occurred in transfected cells and tyrosine phosphorylated tau was identified in human neuroblastoma cells as well.	Tyrosine	80-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
9763511-11	1998	The tyrosine phosphorylation of tau by fyn may also have a role in neuropathogenesis, as fyn is upregulated in Alzheimer"s disease.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-42
9763511-11	1998	The tyrosine phosphorylation of tau by fyn may also have a role in neuropathogenesis, as fyn is upregulated in Alzheimer"s disease.	Tyrosine	4-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-92
9856337-5	1998	In addition, the proline-rich domain of Sos also bound to the SH3 domains of other src-type tyrosine kinases, src and fyn, but not to that of PLC-gamma.	Proline	17-24	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	118-121
9712037-5	1998	Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors.	Lysine	78-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	162-165
9712037-5	1998	Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors.	Tyrosine	203-211	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	162-165
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	phorbol-12-myristate	30-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	13-acetate	52-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	Tetradecanoylphorbol Acetate	64-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9794375-2	1998	Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.	Tyrosine	55-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	194-197
9794375-2	1998	Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.	Tyrosine	55-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
9762924-6	1998	The sequence of Tctex-1 contained a tyrosine phosphorylation motif and Tctex-1 could be phosphorylated by Fyn in vitro and in vivo.	Tyrosine	36-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
9712039-5	1998	Upon removal of the PTP inhibitor, the tyrosine-phosphorylated proteins, including Lck, Fyn, Syk, Zap70, and CD35 zeta are rapidly dephosphorylated.	Tyrosine	39-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-91
9751998-1	1998	We present the results of studies of an aqueous sample of a highly [15N,2H] enriched protein, the SH3 domain from Fyn.	15n	68-71	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
9751998-1	1998	We present the results of studies of an aqueous sample of a highly [15N,2H] enriched protein, the SH3 domain from Fyn.	Deuterium	72-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
9674711-7	1998	Furthermore, we demonstrated that a single amino acid substitution (Y614F) clearly reduces the phosphotyrosine content of HEK2 and abrogates its ability to bind rasGAP, Crk and Fyn indicating that this residue functions as major phosphorylation and multi-docking site.	Phosphotyrosine	95-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9677430-9	1998	In addition, we found that the ability of the Fyn SH2 domain to precipitate tyrosine-phosphorylated proteins, including the CD3zeta chain, was enhanced after T cell stimulation with mitogenic pairs of CD2 mAbs.	Tyrosine	76-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-49
9677430-11	1998	We thus propose that stimulation through the CD2 receptor leads to the tyrosine phosphorylation of intracellular proteins, including CD3zeta itself, which in turn bind to the Fyn-SH2 domain, allowing the direct association of the Fyn SH3 domain with CD2 and the initiation of downstream signaling events.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	175-178
9677430-11	1998	We thus propose that stimulation through the CD2 receptor leads to the tyrosine phosphorylation of intracellular proteins, including CD3zeta itself, which in turn bind to the Fyn-SH2 domain, allowing the direct association of the Fyn SH3 domain with CD2 and the initiation of downstream signaling events.	Tyrosine	71-79	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	230-233
9603925-2	1998	We have shown recently that cross-linking CD43 on the cell surface of human T lymphocytes with the anti-CD43 monoclonal antibody L10 leads to CD43-Fyn kinase interactions and to Fyn phosphorylation on tyrosine residues.	Tyrosine	201-209	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	147-150
9647655-7	1998	ATP induces tyrosine phosphorylation of AE1, activation of the tyrosine kinase Fyn, and association of both Fyn and FAK with AE1.	Adenosine Triphosphate	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
9647655-7	1998	ATP induces tyrosine phosphorylation of AE1, activation of the tyrosine kinase Fyn, and association of both Fyn and FAK with AE1.	Adenosine Triphosphate	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
9603925-2	1998	We have shown recently that cross-linking CD43 on the cell surface of human T lymphocytes with the anti-CD43 monoclonal antibody L10 leads to CD43-Fyn kinase interactions and to Fyn phosphorylation on tyrosine residues.	Tyrosine	201-209	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	178-181
9603925-3	1998	This interaction seems to be mediated by the SH3 domain of Fyn and a proline-rich sequence located in the cytoplasmic domain of CD43.	Proline	69-76	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
9535867-8	1998	These findings implicate Fyn as an adaptor protein that facilitates the interaction between Syk and Cbl, and suggest that Src and Syk family PTKs coordinately regulate the tyrosine phosphorylation of Cbl.	Tyrosine	172-180	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
9603471-7	1998	In accordance with the effects on tyrosine phosphorylation is the reduction of TCR/CD3-mediated Fyn and Lck activities in G alpha 16 mutant cells.	Tyrosine	34-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-99
9575143-6	1998	A mechanism for the inhibition of TCR signaling by nocodazole was suggested by in vitro assays, which revealed that the drug inhibited the kinase activity of LCK and, to a lesser extent, FYN.	Nocodazole	51-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	187-190
9485402-2	1998	Equilibrium unfolding experiments indicate that, despite the lack of both disulfide bonds and prosthetic groups, Fyn-SH3 is relatively stable with a free energy of folding of -6.0 +/- 0.6 kcal mol-1 at 20 degrees C. Kinetic experiments indicate that the domain refolds in a rapid two-state manner without significant population of intermediates (k = 94.3 s-1 in H2O at 20 degrees C).	Water	362-365	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
9535867-0	1998	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	65-68
9535867-7	1998	This mechanism appears to involve Fyn, since, in addition to its association with the C-terminal region of Cbl, Fyn also associated with Syk and enhanced the Syk-induced tyrosine phosphorylation of Cbl.	Tyrosine	170-178	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
9535867-7	1998	This mechanism appears to involve Fyn, since, in addition to its association with the C-terminal region of Cbl, Fyn also associated with Syk and enhanced the Syk-induced tyrosine phosphorylation of Cbl.	Tyrosine	170-178	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
9525940-0	1998	Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells.	Tyrosine	65-73	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
9525940-7	1998	Among these kinases, Fyn and Yes demonstrate strong binding to c-Cbl, which involves both phosphotyrosine-dependent and phosphotyrosine-independent mechanisms.	Phosphotyrosine	90-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
9525940-7	1998	Among these kinases, Fyn and Yes demonstrate strong binding to c-Cbl, which involves both phosphotyrosine-dependent and phosphotyrosine-independent mechanisms.	Phosphotyrosine	120-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
9345044-2	1997	As normal T-cell activation involves early tyrosine phosphorylation induced by the T-cell antigen receptor-associated src-family protein tyrosine kinase p59(fyn(T)) (Fyn), we examined a potential role for this kinase in HIV-related immune dysfunction.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	157-160
9495830-6	1998	Our engineering strategy is generally applicable to the Src family kinases: mutation of the corresponding residue (Thr339 to glycine) in the Fyn kinase confers specificity for N6-(benzyl) ATP on Fyn.	n6-(benzyl) atp	176-191	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
9495830-6	1998	Our engineering strategy is generally applicable to the Src family kinases: mutation of the corresponding residue (Thr339 to glycine) in the Fyn kinase confers specificity for N6-(benzyl) ATP on Fyn.	n6-(benzyl) atp	176-191	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	195-198
9495830-9	1998	As the identical mutation in the Src-family kinase Fyn confers on Fyn the ability to recognize the same unnatural ATP analog, our strategy is likely to be generally applicable to other protein kinases and may help to identify the direct targets of specific kinases.	Adenosine Triphosphate	114-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
9495830-9	1998	As the identical mutation in the Src-family kinase Fyn confers on Fyn the ability to recognize the same unnatural ATP analog, our strategy is likely to be generally applicable to other protein kinases and may help to identify the direct targets of specific kinases.	Adenosine Triphosphate	114-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
9452460-11	1998	The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556, a specific inhibitor of Src-like kinase, abrogates both the colchicine-induced ERK activation and IL-1 production.	Colchicine	54-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-154
9452460-11	1998	The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556, a specific inhibitor of Src-like kinase, abrogates both the colchicine-induced ERK activation and IL-1 production.	cp 118556	104-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-154
9452460-11	1998	The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556, a specific inhibitor of Src-like kinase, abrogates both the colchicine-induced ERK activation and IL-1 production.	Colchicine	175-185	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	139-154
9447983-2	1998	After insulin-dependent tyrosine phosphorylation, c-Cbl specifically associates with endogenous c-Crk and Fyn.	Tyrosine	24-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-109
9345044-2	1997	As normal T-cell activation involves early tyrosine phosphorylation induced by the T-cell antigen receptor-associated src-family protein tyrosine kinase p59(fyn(T)) (Fyn), we examined a potential role for this kinase in HIV-related immune dysfunction.	Tyrosine	43-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	166-169
9344703-3	1997	Pretreatment with gp160 resulted in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells, and a subset of CD4+ cells underwent activation-induced cell death.	Tyrosine	57-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-92
9351806-5	1997	RESULTS: The structure of the Fyn SH2 domain in complex with a phosphotyrosyl peptide (EPQpYEEIPIYL) was determined by high resolution NMR spectroscopy.	phosphotyrosyl peptide	63-85	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	30-33
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
9351806-10	1997	The presence of a type-I" turn in the BG loop, which is dependent on the presence of a glycine residue at position BG3, is indicative of a binding pocket, characteristic of the Src family, SykC and Abl, rather than a binding groove found in PLC-gamma 1C, p85 alpha N and Shc, for example.	Glycine	87-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	159-162
9351809-5	1997	Comparison of the bound and unbound Nef structures revealed that a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding, is partially disordered in the absence of the binding partner; this motif only fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain.	Proline	67-74	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	314-317
9351809-5	1997	Comparison of the bound and unbound Nef structures revealed that a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding, is partially disordered in the absence of the binding partner; this motif only fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain.	pro-x-x-pro	87-98	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	314-317
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Arginine	40-48	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Aspartic Acid	87-90	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Hydrogen	162-170	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9207119-2	1997	FYN binding protein (FYB or p120/130) associates with p59(fyn), the TcRzeta/CD3 complex, and becomes tyrosine-phosphorylated in response to receptor ligation.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
9326235-10	1997	Using affinity precipitation, WASP was found to bind to Src SH3-containing proteins Fyn, Lck, PLC-gamma, and Grb2, and mutated WASP, if expressed, was able to bind to Fyn-glutathione S-transferase (GST) fusion protein.	Glutathione	171-182	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	167-170
9255758-4	1997	By contrast, Fyn activation in anti-CD3 stimulated PBT cells from a substantial proportion of elderly humans was reduced compared to anti-CD3 stimulated PBT cells from young humans.	(E)-2-(pent-3-en-1-yn-1-yl)thiophene	51-54	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
9341742-4	1997	The results show that addition of DEX and PGE2 to anti-CD3 mAb-stimulated T-cells inhibits the induction of p56lck but not p59fyn kinase activity nor is the tyrosine phosphorylation of PLC gamma altered appreciably.	Dinoprostone	42-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	123-129
9315629-9	1997	The formation of the Sam68 complex was inhibited by p59fyn, suggesting that tyrosine phosphorylation regulates Sam68 oligomerization.	Tyrosine	76-84	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-58
9279365-5	1997	Fyn antisense (AS) phosphorothioate oligonucleotides (s-oligos) inhibited the up-regulation of both M-CSFR and c-fms transcripts in bryo 1-treated THP-1 cells.	Phosphorothioate Oligonucleotides	19-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
9188452-7	1997	In vitro binding studies using glutathione S-transferase fusion proteins derived from the SH2 or SH3 domains of Fyn suggested that both Fyn domains can participate in Fyn/Cas interaction.	Glutathione	31-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	112-115
9188452-7	1997	In vitro binding studies using glutathione S-transferase fusion proteins derived from the SH2 or SH3 domains of Fyn suggested that both Fyn domains can participate in Fyn/Cas interaction.	Glutathione	31-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	136-139
9188452-7	1997	In vitro binding studies using glutathione S-transferase fusion proteins derived from the SH2 or SH3 domains of Fyn suggested that both Fyn domains can participate in Fyn/Cas interaction.	Glutathione	31-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	136-139
9195899-7	1997	SKAP55 is detected in resting human T-lymphocytes as a constitutively tyrosine phosphorylated protein that selectively interacts with p59(fyn).	Tyrosine	70-78	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
9279365-5	1997	Fyn antisense (AS) phosphorothioate oligonucleotides (s-oligos) inhibited the up-regulation of both M-CSFR and c-fms transcripts in bryo 1-treated THP-1 cells.	s-oligos	54-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
9201723-4	1997	Mutation of the palmitoylation site (cysteine-3) within Fyn16-beta-galactosidase or wild-type Fyn abrogated plasma membrane localization, resulting in redistribution of the mutant proteins into intracellular membranes.	Cysteine	37-45	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
9201723-5	1997	Substitution of the SH4 motif within Fyn with heterologous sequences from other palmitoylated proteins (G alpha o and GAP43) revealed that the presence of palmitate is sufficient to direct plasma membrane localization independent of surrounding amino acid sequences and myristate.	Palmitates	155-164	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
9045636-3	1997	To identify the molecules downstream of Fyn, we analyzed the tyrosine phosphorylation of cellular proteins in the cells.	Tyrosine	61-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
9201723-6	1997	Palmitoylated Fyn chimeras were also enriched in the Triton X-100-resistant matrix, whereas nonpalmitoylated forms of these proteins were detected in the detergent-soluble fraction.	Octoxynol	53-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
9201723-7	1997	The palmitate moiety on Fyn exhibited a half-life of 1.5-2 h. In contrast, the half-life of the polypeptide backbone was 8 h, indicating that palmitoylation is a reversible modification.	Palmitates	4-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
9144252-3	1997	Here we show that the inhibition of sensory neuron N-type Ca2+ channels produced by gamma-aminobutyric acid involves a novel, rapidly activating tyrosine kinase signaling pathway that is mediated by Galphao and a src-like kinase.	gamma-Aminobutyric Acid	84-107	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	213-228
9079813-4	1997	Results demonstrate that in BW5147 wild-type TCR, tail-less zeta TCR, CD3epsilon, and TCRzeta transduce signals leading to tyrosine phosphorylation of similar sets of cellular substrates, including the receptor subunits, Fyn, ZAP-70, and phospholipase Cgamma1 (PLCgamma1).	Tyrosine	123-131	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-224
8943314-4	1996	Furthermore, AChRs affinity-isolated from C2 myotubes using alpha-bungarotoxin-Sepharose were specifically associated with Src and Fyn and had tyrosine-phosphorylated beta subunits.	Sepharose	79-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9211750-3	1997	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, autoradiography, and phospho-amino acid analysis revealed the presence of in vitro tyrosine phosphorylated proteins that were subsequently identified by re-precipitation (and/or by western blotting) as the respective C-type lectin molecules and Src family kinases Lck, Lyn, and Fyn.	Tyrosine	142-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	337-340
9124414-12	1997	IP3R1 function is regulated by at least two major cellular signaling pathways: the second messenger IP3 activates the channel, and phosphorylation by nonreceptor protein tyrosine kinases (e.g., Fyn) increase its open probability.	Inositol 1,4,5-Trisphosphate	0-3	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	194-197
9135555-4	1997	Herbimycin A, an inhibitor of the src family protein tyrosine kinases dramatically inhibited this CD26-mediated effect on tyrosine phosphorylation.	herbimycin	0-12	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
9135555-4	1997	Herbimycin A, an inhibitor of the src family protein tyrosine kinases dramatically inhibited this CD26-mediated effect on tyrosine phosphorylation.	Tyrosine	53-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
8995358-11	1997	These data suggest the unexpected conclusion that the Fyn SH2 domain may bind to Cbl in a phosphotyrosine-independent manner.	Phosphotyrosine	90-105	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-57
8943314-5	1996	We suggest that AChRs are initially phosphorylated by Src and subsequently bind Fyn in a phosphotyrosine-dependent manner.	Phosphotyrosine	89-104	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	80-83
8941336-3	1996	The major autophosphorylation site is tyrosine-397, which interacts with the Src homology 2 (SH2) domain of Src-family kinases including Src and Fyn.	Tyrosine	38-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	145-148
8961927-0	1996	Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.	Proline	101-108	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-91
8798606-6	1996	These data show that alterations that modify the ability of Ig-alpha and Ig-beta to interact in vitro with the src kinase fyn (switch between QTAT and DCSM) also determine signal transduction capabilities of these molecules expressed in B cells.	dcsm	151-155	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
8810341-7	1996	By examining the ability of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP.	Proline	228-235	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-171
8798606-2	1996	Ig-alpha and Ig-beta ITAMs only differ by four amino acids located before the second conserved tyrosine (DCSM in Ig-alpha and QTAT in Ig-beta), which determine the in vitro association of Ig-alpha with the src kinase fyn.	Tyrosine	95-103	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	217-220
8955343-4	1996	This genetic screen clearly indicates that the interaction between SH3 domain of Fyn and the proline-rich region (residues: 80-104) of PI-3 kinase is highly specific.	Proline	93-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
8955343-5	1996	Mutational analysis revealed that amino acid residues Asp92, Tyr93, Arg96 and Thr97 of the SH3 domain of Fyn are essential for interacting with the proline-rich peptide of PI-3 kinase.	Proline	148-155	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	105-108
8910342-5	1996	We also provide evidence that upon CD43 cross-linking, Fyn is tyrosine-phosphorylated in a time-dependent manner.	Tyrosine	62-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
8910342-6	1996	Our results suggest that CD43 cross-linking on the T cell surface induces the interaction between CD43 and Fyn, presumably through the Fyn SH3 domain and a putative SH3 binding site in CD43, leading to Fyn tyrosine phosphorylation and signal propagation.	Tyrosine	206-214	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
8910342-6	1996	Our results suggest that CD43 cross-linking on the T cell surface induces the interaction between CD43 and Fyn, presumably through the Fyn SH3 domain and a putative SH3 binding site in CD43, leading to Fyn tyrosine phosphorylation and signal propagation.	Tyrosine	206-214	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
8910342-6	1996	Our results suggest that CD43 cross-linking on the T cell surface induces the interaction between CD43 and Fyn, presumably through the Fyn SH3 domain and a putative SH3 binding site in CD43, leading to Fyn tyrosine phosphorylation and signal propagation.	Tyrosine	206-214	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
9172452-2	1996	Csk is probably involved in the downregulation of TCR signaling by C-terminal tyrosine phosphorylation of Lck and Fyn, but the mechanism whereby Csk targets these Src family members is not known.	Tyrosine	78-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	114-117
8900205-0	1996	Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells.	Tyrosine	24-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
8900205-2	1996	We have demonstrated earlier that the TcR/CD3-induced activation of Fyn results in tyrosine phosphorylation of several Fyn-associated proteins, including a protein of 116 kDa.	Tyrosine	83-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
8900205-2	1996	We have demonstrated earlier that the TcR/CD3-induced activation of Fyn results in tyrosine phosphorylation of several Fyn-associated proteins, including a protein of 116 kDa.	Tyrosine	83-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	119-122
8900205-8	1996	This increase is likely due to the involvement of Fyn SH2 in the interactions between Fyn and tyrosine-phosphorylated c-Cbl.	Tyrosine	94-102	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
8900205-8	1996	This increase is likely due to the involvement of Fyn SH2 in the interactions between Fyn and tyrosine-phosphorylated c-Cbl.	Tyrosine	94-102	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
8798606-6	1996	These data show that alterations that modify the ability of Ig-alpha and Ig-beta to interact in vitro with the src kinase fyn (switch between QTAT and DCSM) also determine signal transduction capabilities of these molecules expressed in B cells.	qtat	142-146	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-125
8883579-8	1996	HIV-related src-family PTK activation was not a function of the gp120-CD4-Lck interaction and occurred in the presence of 10 mmol/l zidovudine indicating that reverse transcriptase and activation of the HIV genome is not required.	Zidovudine	132-142	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	12-16
8780693-1	1996	The association of glycosylphosphatidylinositol (GPI)-anchored cell surface glycoproteins with Src-family protein tyrosine kinases was analysed in intact T lymphocyte plasma membranes.	Glycosylphosphatidylinositols	19-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
9183644-3	1996	Several tyrosine-phosphorylated proteins have been identified such as PLC gamma (pp140), pp125FAK(pp120), Paxillin(pp70), p59fyn/p56lck(pp60-55) and MAPkinase (pp45).	Tyrosine	8-16	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	122-128
8780693-1	1996	The association of glycosylphosphatidylinositol (GPI)-anchored cell surface glycoproteins with Src-family protein tyrosine kinases was analysed in intact T lymphocyte plasma membranes.	Glycosylphosphatidylinositols	49-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	95-98
8766549-1	1996	The common leukocyte antigen CD45 plays a central role in T cell activation in coupling the T cell receptor (TCR) to the phosphatidylinositol pathway via interactions with TCR-associated protein tyrosine kinases lck and fyn.	Phosphatidylinositols	121-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	220-223
8695788-10	1996	Analysis of tyrosine-phosphorylated RAFTK from adherent transfected COS cells showed that the Src homology 2 (SH2) domains of the Src and Fyn protein kinases as well as the Grb2 adaptor protein were able to specifically associate with RAFTK.	Tyrosine	12-20	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
8760790-3	1996	Here we show that ligation of T cell receptor (TCR) by alloantigen alone, which results in anergy, activates tyrosine phosphorylation of TCR zeta and its association with fyn.	Tyrosine	109-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	171-174
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
8655574-0	1996	Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization.	Tyrosine	89-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-31
8655574-1	1996	The src family tyrosine kinase p59fyn binds to a signaling motif contained in subunits of the TCR known as the immune-receptor tyrosine-based activation motif (ITAM).	Tyrosine	15-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
8655574-1	1996	The src family tyrosine kinase p59fyn binds to a signaling motif contained in subunits of the TCR known as the immune-receptor tyrosine-based activation motif (ITAM).	Tyrosine	15-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-37
8655574-12	1996	Four residues (Gly2, Cys3, Lys7, and Lys9) were required for efficient binding of p59fyn to the TCR.	Glycylglycine	15-19	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-88
8805554-10	1996	The relative binding affinities of the three ligand peptides and their orientation within the Fyn SH3 complex were consistent with recently proposed models for the binding of "consensus" polyproline sequences.	polyproline	187-198	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Lysine	60-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	163-166
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Glutamic Acid	77-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	82-85
8639560-18	1996	Finally, it is proposed that the amino acid substitution of Lys 88 (blk) for Glu [fyn(T)] is important for the observed differences in specificity between blk and fyn(T) SH2 domains.	Glutamic Acid	77-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	163-166
8621646-2	1996	Csk may be involved in the down-regulation of T cell receptor (TCR) signaling by C-terminal tyrosine phosphorylation of Lck and Fyn; however, it is not known how Csk activity is regulated or how it targets these Src family members.	Tyrosine	92-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
8626561-8	1996	These interactions were specific as molecules known to be tyrosine-phosphorylated following TcR cross-linking, phospholipase C-gamma1 and Fyn, were not bound.	Tyrosine	58-66	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	138-141
8734787-0	1996	Stimulation of the T-cell antigen receptor-CD3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD45: evidence for two interconnected Lck/Fyn- or zap-70-dependent signaling pathways.	pervanadate	111-122	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	194-197
9019541-6	1996	Glutamate-activated currents (evoked every 20 s for up to 20 min) were increased by src and fyn kinases without affecting the desensitization and deactivation kinetics in NR1-NR2A but the kinases had no effects in NR1-NR2B, NR1-NR2C and NR1-NR2D receptor-channels, suggesting that a phosphorylation site in NR2A is targeted.	Glutamic Acid	0-9	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	92-95
9019541-8	1996	In a mutant channel consisting of NR1 and a C-terminal deletion mutant of NR2A (NR2A delta C), src and fyn kinases lost their potentiating effects indicating that the phosphorylation of tyrosine(s) in the C-terminal domain of NR2A affects the current flux through native NMDA receptor-channels.	Tyrosine	186-194	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	103-106
8631299-8	1996	Shc associates with the SH3 domain of Fyn whose tyrosine kinase activity is activated by Ang II with a similar time course as that of tyrosine phosphorylation of Shc.	Tyrosine	48-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
8631299-9	1996	Ang II-induced increase in the guanine nucleotide exchange activity was inhibited by a peptide ligand specific to the SH3 domain of the Src family tyrosine kinases.	Guanine Nucleotides	31-49	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	136-139
7589084-2	1995	In the present study, we explored the role of phosphorylation of the two ITAM tyrosine residues in the interactions of the motif with the PTK ZAP-70 and p59fyn.	Tyrosine	78-86	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	153-159
7589480-3	1995	Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of FasL.	Proline	73-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
7589101-7	1995	We investigated the capacity of CD19 cytoplasmic tyrosines to bind both Fyn and PI-3 kinase SH2-domain fusion proteins.	Tyrosine	49-58	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
7589101-11	1995	Two different tyrosines (Y405 and Y445) bound preferentially to the Fyn SH2-domain fusion protein via a novel sequence, Y-E-N-D/E, different from that previously reported for the Fyn SH2 domain.	Tyrosine	14-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
7589101-11	1995	Two different tyrosines (Y405 and Y445) bound preferentially to the Fyn SH2-domain fusion protein via a novel sequence, Y-E-N-D/E, different from that previously reported for the Fyn SH2 domain.	Tyrosine	14-23	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	179-182
8566014-0	1995	Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.	Tyrosine	38-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	127-133
8566014-5	1995	However, following T cell activation, it becomes rapidly phosphorylated on tyrosine residues and subsequently associates with the SH2 domain of fyn.	Tyrosine	75-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	144-147
8566014-6	1995	Interestingly, constitutively tyrosine-phosphorylated alpha-tubulin that is able to interact with the fyn-SH2 domain is expressed in peripheral blood T lymphoblasts isolated from leukemic patients in the absence of external stimulation.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	102-105
7499298-2	1995	CD45 activates the Src family protein-tyrosine kinases, p56lck and p59fyn, by dephosphorylating a negative regulatory tyrosine in the carboxyl terminus.	Tyrosine	38-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
7499298-2	1995	CD45 activates the Src family protein-tyrosine kinases, p56lck and p59fyn, by dephosphorylating a negative regulatory tyrosine in the carboxyl terminus.	Tyrosine	38-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-73
7589084-3	1995	The data show that the phosphorylation of a single tyrosine within the motif enables binding of p59fyn, whereas phosphorylation of both tyrosines within the motif is required for maximal binding of the PTK ZAP-70.	Tyrosine	51-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-102
7589084-5	1995	ZAP-70 binds with low efficiency to a singly phosphorylated ITAM, but shows preferential binding to the C-terminal phosphotyrosine in the ITAM, whereas p59fyn binds selectively to the N-terminal phosphotyrosine.	Phosphotyrosine	195-210	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	152-158
7673711-8	1995	Using immunoblotting, we have identified some of the tyrosine-phosphorylated proteins to be phospholipase C gamma (pp140), pp125 focal adhesion kinase (pp120), paxillin (pp70 and pp50), p59fyn/p56lck (pp60-55), and mitogen-activated protein kinase (pp45).	Tyrosine	53-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	186-192
7545683-5	1995	Here, analysis of CD20-associated molecules has revealed that CD20 is associated with the Src family tyrosine kinases p56/53lyn, p56lck, and p59fyn and with 75/80-kDa proteins phosphorylated in vivo on tyrosine residues.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
7545683-5	1995	Here, analysis of CD20-associated molecules has revealed that CD20 is associated with the Src family tyrosine kinases p56/53lyn, p56lck, and p59fyn and with 75/80-kDa proteins phosphorylated in vivo on tyrosine residues.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-147
7568038-6	1995	In this study, we demonstrate in coexpression studies that p56Lck and p59Fyn phosphorylate CD28 primarily at Tyr-191 of the Tyr-Met-Asn-Met motif, inducing a 3- to 8-fold increase in p85 (subunit of PI 3-kinase) and GRB-2 SH2 binding to CD28.	Asparagine	132-135	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-76
7539724-4	1995	Activation of lymphocytes through the T cell receptor (TCR) in collaboration with cell surface accessory molecules results in rapid increases in tyrosine phosphorylation, probably through the recruitment and activation of src-family protein tyrosine kinases (PTK) such as lck and fyn which have been implicated in mediating the proximal signalling events mediated through the TCR.	Tyrosine	145-153	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	280-283
7543423-8	1995	Furthermore, herbimycin A did not inhibit but rather augmented apoptosis at concentrations which effectively degraded the src related kinases lck and fyn.	herbimycin	13-25	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
7621861-0	1995	Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A.	Calcium	90-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Calcium	104-111	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Cycloheximide	125-138	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Cycloheximide	140-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Cyclosporine	164-167	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Calcium	199-206	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7621861-3	1995	Generation of both the anergic state and the increased p59fyn activity was prevented in the presence of calcium-free medium, cycloheximide (CHX), or cyclosporin A (CsA), and could be mimicked by the calcium ionophore ionomycin.	Ionomycin	217-226	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-61
7739523-9	1995	Deletion of the unique domain of Lck, or its replacement by the equivalent sequence from p59fyn, also increased the extent of tyrosine 505 phosphorylation in vivo.	Tyrosine	126-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-95
7759480-5	1995	In this study, we characterized the inhibitory effects of leflunomide on Src family (p56lck and p59fyn)-mediated protein tyrosine phosphorylation.	Leflunomide	58-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
7759480-5	1995	In this study, we characterized the inhibitory effects of leflunomide on Src family (p56lck and p59fyn)-mediated protein tyrosine phosphorylation.	Leflunomide	58-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-102
7759480-5	1995	In this study, we characterized the inhibitory effects of leflunomide on Src family (p56lck and p59fyn)-mediated protein tyrosine phosphorylation.	Tyrosine	121-129	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
7759480-5	1995	In this study, we characterized the inhibitory effects of leflunomide on Src family (p56lck and p59fyn)-mediated protein tyrosine phosphorylation.	Tyrosine	121-129	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	96-102
7759480-6	1995	Leflunomide was able to inhibit p59fyn and p56lck activity in in vitro tyrosine kinase assays.	Leflunomide	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	32-38
7760813-6	1995	In addition, autophosphorylation of ZAP-70 when bound to zeta or eta resulted in the generation of multiple distinct ZAP-70 phosphorylated tyrosine residues which had the capacity to bind the SH2 domains of fyn, lck, GAP, and abl.	Tyrosine	139-147	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	207-210
7961974-9	1994	These data suggest that the association of the AChR with Fyn and Fyk is mediated by an interaction of the tyrosine-phosphorylated delta subunit of the receptor with the SH2 domains of the protein tyrosine kinases.	Tyrosine	106-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
7730365-3	1995	In the case of the platelet-derived growth factor (PDGF) receptor, the major binding site for Src family tyrosine kinases is in the juxtamembrane domain and includes tyrosine 579 (Mori, S., Ronnstrand, L., Yokote, K., Engstrom, A., Courtneidge, S. A., Claesson-Welsh, L., and Heldin, C-H. (1993) EMBO J.	Tyrosine	105-113	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	94-97
7537495-6	1995	Using the anti-Src antibody, which is reactive to Src, Fyn and Yes, we obtained evidence for an association between the Src family tyrosine kinase and the tyrosine-phosphorylated Sky receptor.	Tyrosine	131-139	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
7822789-0	1995	Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.	Calcium	39-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	6-12
7822789-8	1995	We find that cell lines expressing significantly reduced levels of p59fyn(T) exhibit significantly lower calcium influx following OKT3 activation.	Calcium	105-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-73
7822789-10	1995	These data indicate that p59fyn(T) can regulate calcium influx by a mechanism distinct from PIP2 hydrolysis.	Calcium	48-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-31
7844523-6	1995	ARAMs are activated by tyrosine phosphorylation that enables binding of tyrosine protein kinases such as lyn and fyn.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	113-116
7799925-5	1995	Reconstitution of complexes containing p62 and the src family kinase p59fyn in HeLa cells demonstrated that complex formation resulted in tyrosine phosphorylation of p62 and was mediated by both the SH3 and SH2 domains of p59fyn.	Tyrosine	138-146	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	69-75
7799925-5	1995	Reconstitution of complexes containing p62 and the src family kinase p59fyn in HeLa cells demonstrated that complex formation resulted in tyrosine phosphorylation of p62 and was mediated by both the SH3 and SH2 domains of p59fyn.	Tyrosine	138-146	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	222-228
7989748-0	1994	Platelet-activating factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and phosphatidylinositol 3-kinase in a human B cell line.	Tyrosine	39-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
7989748-8	1994	We have thus demonstrated that the activation of tyrosine kinases is an important proximate step in PAF-mediated signal transduction in B cells, leading to tyrosine phosphorylation and activation of PLC-gamma 1, Fyn and Lyn kinases, and PtdIns 3-kinase.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	212-215
7730365-8	1995	The activated colony stimulating factor-1 (CSF-1) receptor, which is known to associate with Src family kinases, has a sequence in its juxtamembrane region similar to that surrounding Tyr-579 of the PDGF receptor, and a phosphopeptide modeled on this sequence competed the association of Fyn with the receptor in vitro.	Tyrosine	184-187	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	288-291
7730365-11	1995	These observations support a model in which the enzymatic activity of Src family tyrosine kinases is controlled by intra- and intermolecular interactions of tyrosine-phosphorylated peptides with the SH2 domain of the kinases.	Tyrosine	81-89	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
7737297-2	1995	In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, presumably by positively regulating Src-family PTK.	Tyrosine	29-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	169-172
7822337-6	1995	SH2 domains of p56lck and p59fyn precipitated the same proteins as anti-phosphotyrosine antibodies after IL-4 stimulation, which suggests that a src-type kinase may be involved in signal transduction through the IL-4 receptor.	Phosphotyrosine	72-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	26-32
7528772-2	1995	TCR-mediated activation of the src-family kinases, Lck and Fyn, results in tyrosine phosphorylation of the TCR zeta and CD3 chains.	Tyrosine	75-83	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
7773778-4	1994	The orientation of the bound peptide is opposite to that of proline-rich peptides bound to the SH3 domains of Abl, Fyn and p85.	Proline	60-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
7980442-13	1994	To confirm that palmitoylation was occurring on cysteines in the N-terminal region of Fyn, site-directed mutagenesis was used to replace the cysteines at positions 3 and 6 with alanine.	Cysteine	48-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
7980442-13	1994	To confirm that palmitoylation was occurring on cysteines in the N-terminal region of Fyn, site-directed mutagenesis was used to replace the cysteines at positions 3 and 6 with alanine.	Cysteine	141-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
7980442-13	1994	To confirm that palmitoylation was occurring on cysteines in the N-terminal region of Fyn, site-directed mutagenesis was used to replace the cysteines at positions 3 and 6 with alanine.	Alanine	177-184	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-89
7958618-4	1994	As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action.	Hydrogen Peroxide	93-110	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-59
7958618-4	1994	As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action.	Glutathione Disulfide	140-144	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-59
7522230-3	1994	Fyn activity, as measured by autophosphorylation and tyrosine phosphorylation of an exogenous substrate, was maximal 5 s to 1 min following receptor cross-linking.	Tyrosine	53-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
8089104-4	1994	Analysis of signal transduction events shows that pervanadate induces the activity of the src family of tyrosine kinases lck and fyn and the tyrosine phosphorylation of a major IL-2 responsive protein of 97 kDa.	pervanadate	50-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
7515097-0	1994	CD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line.	Tyrosine	86-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	119-125
8089104-4	1994	Analysis of signal transduction events shows that pervanadate induces the activity of the src family of tyrosine kinases lck and fyn and the tyrosine phosphorylation of a major IL-2 responsive protein of 97 kDa.	pervanadate	50-61	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
8089104-4	1994	Analysis of signal transduction events shows that pervanadate induces the activity of the src family of tyrosine kinases lck and fyn and the tyrosine phosphorylation of a major IL-2 responsive protein of 97 kDa.	Tyrosine	104-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
8089104-4	1994	Analysis of signal transduction events shows that pervanadate induces the activity of the src family of tyrosine kinases lck and fyn and the tyrosine phosphorylation of a major IL-2 responsive protein of 97 kDa.	Tyrosine	104-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
7524477-7	1994	Repression of Fyn activity by Csk reduced binding of Fyn to phosphopeptides to undetectable levels, supporting the model that predicts an intramolecular interaction of the Fyn SH2 domain with a C-terminal phosphotyrosine residue.	Phosphotyrosine	205-220	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
7524477-7	1994	Repression of Fyn activity by Csk reduced binding of Fyn to phosphopeptides to undetectable levels, supporting the model that predicts an intramolecular interaction of the Fyn SH2 domain with a C-terminal phosphotyrosine residue.	Phosphotyrosine	205-220	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-56
7524477-7	1994	Repression of Fyn activity by Csk reduced binding of Fyn to phosphopeptides to undetectable levels, supporting the model that predicts an intramolecular interaction of the Fyn SH2 domain with a C-terminal phosphotyrosine residue.	Phosphotyrosine	205-220	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	53-56
7518463-2	1994	This is now extended to three other members of this family by showing incorporation of [3H]palmitate into p59fyn, p55fgr, and p56hck, but not into p60src.	[3h]palmitate	87-100	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
7518463-4	1994	Individual replacement of the two cysteine residues within the first 10 amino acids of p59fyn and p56lck with serine indicated that Cys3 was the major determinant of palmitoylation, as well as association of the PTK with glycosyl-phosphatidylinositol-anchored proteins.	Cysteine	34-42	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	87-93
8206991-2	1994	In this report, we identify cysteine residues within the N-terminal region of the Src family member Fyn which serve as sites for palmitylation.	Cysteine	28-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	100-103
8206991-3	1994	To facilitate detection of protein fatty acylation, p59fyn was overexpressed in COS cells and incubated with radioiodinated fatty acid analogs of myristate (IC13) or palmitate (IC16).	Fatty Acids	124-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-58
8206991-3	1994	To facilitate detection of protein fatty acylation, p59fyn was overexpressed in COS cells and incubated with radioiodinated fatty acid analogs of myristate (IC13) or palmitate (IC16).	Palmitates	166-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-58
8206991-4	1994	Incorporation of both fatty acids into p59fyn was readily observed.	Fatty Acids	22-33	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	39-45
8083187-7	1994	Tyrosine-phosphorylated p120cbl binds to glutathione S-transferase fusion proteins generated from SH2 domains of the Fyn, Lck, and Blk protein tyrosine kinases, GTPase-activating protein and phospholipase C gamma.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	117-120
7914908-4	1994	Since tyrosine phosphorylated pp29/30 selectively interacts with the Src homology type 2 domains (SHZ) of the protein tyrosine kinases p56lck and p59fyn but not ZAP70 the present data suggest that pp29/30 represents a novel signaling receptor associated phosphoprotein likely involved in the activation of human T lymphocytes and NK cells.	Tyrosine	6-14	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	146-152
7515097-0	1994	CD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line.	Calcium	61-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	119-125
7515102-12	1994	In addition, the alteration in the tyrosine phosphorylation of PTKs Lyn, Fyn, and Syk was directly demonstrated.	Tyrosine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
7514299-0	1994	Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.	Tyrosine	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
8196616-13	1994	We propose that the activation of cells by the tyrosine activating motif occurs in four discrete steps: binding of p59fyn, phosphorylation of the motif, binding of ZAP-70, and activation of ZAP-70 kinase activity.	Tyrosine	47-55	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-121
8196616-4	1994	Here we demonstrate that the tyrosine-based activation motif is required and sufficient for association with the tyrosine kinases p59fyn and ZAP-70, suggesting that association with these kinases is a general feature of this motif.	Tyrosine	29-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	130-136
7514295-0	1994	Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.	Tyrosine	31-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
8128248-2	1994	Here it was found that the Src homology 3 (SH3) domain of Lyn and Fyn bound to a proline-rich region (residues 84 to 99) within the 85-kilodalton subunit (p85) of PI-3 kinase.	Proline	81-88	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
7514295-2	1994	Two Src-family protein-tyrosine kinases, the TCR-associated p59fyn (Fyn) and the CD4/8-associated p56lck (Lck), have emerged as the likely mediators of early tyrosine phosphorylation in T cells.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-66
7514295-2	1994	Two Src-family protein-tyrosine kinases, the TCR-associated p59fyn (Fyn) and the CD4/8-associated p56lck (Lck), have emerged as the likely mediators of early tyrosine phosphorylation in T cells.	Tyrosine	23-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
7514295-4	1994	While binding of p120 to Fyn SH2 domain was phosphotyrosine-dependent as expected, its binding to the SH3 domain was independent of tyrosine phosphorylation, as shown by lack of competition with a phosphotyrosyl competitor peptide.	Phosphotyrosine	44-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
7514295-4	1994	While binding of p120 to Fyn SH2 domain was phosphotyrosine-dependent as expected, its binding to the SH3 domain was independent of tyrosine phosphorylation, as shown by lack of competition with a phosphotyrosyl competitor peptide.	Tyrosine	51-59	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
7514295-8	1994	These results provide evidence for a role of the SH3 domains of Fyn and Lck in the recruitment of early tyrosine-phosphorylation substrates to the TCR-associated tyrosine kinases.	Tyrosine	104-112	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	64-67
8183901-1	1994	Among the earliest detectable events in B-cell antigen receptor-mediated signal transduction are the activation of receptor-associated Src-family tyrosine kinases and the tyrosine phosphorylation of Ig-alpha and Ig-beta receptor subunits.	Tyrosine	146-154	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	135-138
8183901-3	1994	Recent studies showed a dramatic increase in the amount of Src-family kinase p59fyn bound to Ig-alpha when ARH1 motif tyrosines were phosphorylated.	Tyrosine	118-127	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	59-62
8183901-3	1994	Recent studies showed a dramatic increase in the amount of Src-family kinase p59fyn bound to Ig-alpha when ARH1 motif tyrosines were phosphorylated.	Tyrosine	118-127	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	77-83
8168489-0	1994	Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.	Tyrosine	21-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
8168490-0	1994	The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.	Tyrosine	9-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	86-92
8126006-0	1994	Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes.	Tyrosine	21-29	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
8126006-2	1994	Here, we report our finding that the activation of p60fyn following TcR cross-linking results in the tyrosine phosphorylation of two Fyn-associated proteins of 82 and 116 kDa.	Tyrosine	101-109	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	133-136
8126006-5	1994	Furthermore, the p60fyn-p82/p116 complex could be dissociated and then reconstituted in vitro using purified recombinant Fyn.	1,10-phenanthroline	28-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-124
8262983-5	1993	Furthermore, normal and active Fyn stimulated transcription from the IL-2 gene promoter when transfected cells were stimulated by concanavalin A plus 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	150-186	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
8294442-1	1994	Src homology 3 (SH3) domains have been recently shown to bind to proline-rich sequences contained in 3BP1, 3BP2, and SOS.	Proline	65-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	0-3
8262983-2	1993	Transient expression of actively mutated Fyn, having Phe-528 instead of Tyr-528 or Thr-338 instead of Ile-338, in Jurkat T-cells stimulated the serum response element (SRE), 12-O-tetradecanoyl-phorbol-13-acetate response element, cyclic AMP response element, and c-fos promoter.	Phenylalanine	53-56	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
7506531-3	1994	Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1.	pervanadate	0-11	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
7506545-5	1993	These results suggested that src-type tyrosine kinases as Fyn and Lyn are responsible for the phosphorylation of MB-1 and B29 heterodimer, but anti-MB-1 stimulation can induce tyrosine phosphorylation reaction mediated by other kinase molecule(s) in the progenitor type cells.	Tyrosine	38-46	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-61
8262983-2	1993	Transient expression of actively mutated Fyn, having Phe-528 instead of Tyr-528 or Thr-338 instead of Ile-338, in Jurkat T-cells stimulated the serum response element (SRE), 12-O-tetradecanoyl-phorbol-13-acetate response element, cyclic AMP response element, and c-fos promoter.	Tetradecanoylphorbol Acetate	174-211	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
8262983-8	1993	Csk, which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases, down-regulated Fyn- and Lck-mediated stimulation of the serum response element and Fyn-mediated enhancement of IL-2 promoter activity.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
8262983-2	1993	Transient expression of actively mutated Fyn, having Phe-528 instead of Tyr-528 or Thr-338 instead of Ile-338, in Jurkat T-cells stimulated the serum response element (SRE), 12-O-tetradecanoyl-phorbol-13-acetate response element, cyclic AMP response element, and c-fos promoter.	Cyclic AMP	230-240	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
8262983-8	1993	Csk, which phosphorylates tyrosine residues in the negative regulatory sites of Src family kinases, down-regulated Fyn- and Lck-mediated stimulation of the serum response element and Fyn-mediated enhancement of IL-2 promoter activity.	Tyrosine	26-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	183-186
8223875-5	1993	Stimulation of [3H]PA production upon CD3 cross-linking was 77% lower in permeabilized CD45- cells than in CD45+ cells, consistent with the reduced activity of p59fyn in CD45- cells.	Tritium	16-18	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-166
8223875-0	1993	Selective coupling of the T cell antigen receptor to phosphoinositide-derived diacylglycerol production in HPB-ALL T cells correlates with CD45-regulated p59fyn activity.	phosphoinositide-derived diacylglycerol	53-92	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	154-160
8227079-5	1993	Using antibodies to fyn and fyk, Fyn was shown to be a 55-kDa protein phosphorylated on tyrosine residues, whereas Fyk was a 56-kDa/53-kDa doublet phosphorylated on serine and tyrosine residues.	Tyrosine	88-96	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	33-36
8223875-5	1993	Stimulation of [3H]PA production upon CD3 cross-linking was 77% lower in permeabilized CD45- cells than in CD45+ cells, consistent with the reduced activity of p59fyn in CD45- cells.	Protactinium	19-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	160-166
15335855-6	1993	Furthermore, crosslinking of the chimeras resulted in tyrosine phosphorylation of the Ig-alpha and Tg-beta tails and their association with the tyrosine kinases PTK72, p53/56(lyn) and p59(fyn).	Tyrosine	54-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
8226767-11	1993	Thus, among proteins that exhibit increased tyrosine phosphorylation following antigen receptor cross-linking, several have been identified that bind preferentially to SH2 domains of Blk, Fyn(T), or Lyn, suggesting that these kinases serve distinct functions.	Tyrosine	44-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	188-191
8373732-4	1993	Surprisingly, these lysines are conserved among several src family members.	Lysine	20-27	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-59
8413237-0	1993	Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.	Cysteine	35-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-95
8413237-0	1993	Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.	Glycosylphosphatidylinositols	122-151	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	89-95
8413237-2	1993	We and others have shown an association between GPI-anchored proteins and the protein tyrosine kinases (PTKs) p56lck and p59fyn, suggesting a pathway for signaling through GPI-anchored proteins.	Glycosylphosphatidylinositols	48-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-127
8413237-2	1993	We and others have shown an association between GPI-anchored proteins and the protein tyrosine kinases (PTKs) p56lck and p59fyn, suggesting a pathway for signaling through GPI-anchored proteins.	Glycosylphosphatidylinositols	172-175	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-127
8344934-2	1993	In this study, we have identified a variant of the fyn kinase at 70-72 kDa (termed p72fyn-R) that can preferentially associate with the TcR/CD3 complex in certain T cells.	p72fyn-r	83-91	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
8344934-5	1993	In addition, two-dimensional phosphotryptic peptide map patterns of TcR/CD3-associated p72fyn and anti-fyn-precipitable p72 were identical.	Peptides	44-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
8327490-0	1993	7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.	9,10-Dimethyl-1,2-benzanthracene	0-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
8327490-0	1993	7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.	Tyrosine	49-57	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
8327490-0	1993	7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.	Inositol 1,4,5-Trisphosphate	191-219	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
8327490-0	1993	7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.	Calcium	255-262	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-69
8327490-9	1993	The mechanism of DMBA-induced tyrosine phosphorylation of phospholipase C-gamma 1 may have been due to an increase in protein-tyrosine kinase activity, since it was found that DMBA produced a > 2-fold increase in the activity of the T-cell receptor-associated Src-family kinases Fyn and Lck.	9,10-Dimethyl-1,2-benzanthracene	17-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	282-285
8353285-0	1993	Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.	Oxygen	9-15	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-154
8353285-0	1993	Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.	Vanadates	115-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-154
8353285-7	1993	Although treatment of cells with H2O2 alone did not affect the activity of src family kinases, treatment with H2O2 plus vanadate led to activation of the p56lck and p59fyn tyrosine kinases.	Hydrogen Peroxide	110-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	165-171
8353285-7	1993	Although treatment of cells with H2O2 alone did not affect the activity of src family kinases, treatment with H2O2 plus vanadate led to activation of the p56lck and p59fyn tyrosine kinases.	Vanadates	120-128	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	165-171
8327490-9	1993	The mechanism of DMBA-induced tyrosine phosphorylation of phospholipase C-gamma 1 may have been due to an increase in protein-tyrosine kinase activity, since it was found that DMBA produced a > 2-fold increase in the activity of the T-cell receptor-associated Src-family kinases Fyn and Lck.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	282-285
8327490-9	1993	The mechanism of DMBA-induced tyrosine phosphorylation of phospholipase C-gamma 1 may have been due to an increase in protein-tyrosine kinase activity, since it was found that DMBA produced a > 2-fold increase in the activity of the T-cell receptor-associated Src-family kinases Fyn and Lck.	9,10-Dimethyl-1,2-benzanthracene	176-180	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	282-285
8327490-10	1993	The kinetics of activation of protein-tyrosine kinases demonstrated that Fyn activity was increased within 10 min of exposure to DMBA, whereas maximal Lck activation required 30 min.	9,10-Dimethyl-1,2-benzanthracene	129-133	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	73-76
8327490-11	1993	Thus, it is likely that the Fyn kinase or other protein-tyrosine kinases may be responsible for the early tyrosine phosphorylation of phospholipase C-gamma 1, which results in inositol 1,4,5-trisphosphate release and mobilization of intracellular Ca2+.	Tyrosine	56-64	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
8327490-11	1993	Thus, it is likely that the Fyn kinase or other protein-tyrosine kinases may be responsible for the early tyrosine phosphorylation of phospholipase C-gamma 1, which results in inositol 1,4,5-trisphosphate release and mobilization of intracellular Ca2+.	Inositol 1,4,5-Trisphosphate	176-204	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
8433999-4	1993	The site of increased tyrosine phosphorylation in Src family members was identified by comparison of cyanogen bromide peptide maps.	Tyrosine	22-30	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
8500615-0	1993	Calcium dependent activation of the NF-AT transcription factor by p59fyn.	Calcium	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-72
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Calcium	30-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Calcium	30-37	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Tetradecanoylphorbol Acetate	118-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Egtazic Acid	137-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Egtazic Acid	137-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Cyclosporine	176-189	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Cyclosporine	176-189	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
8383678-6	1993	Exposure of intact cells to pervanadate also stimulated the in vitro catalytic activities of both p59fyn and p56lck, src family kinases strongly implicated in TCR-mediated signaling.	pervanadate	28-39	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-104
8433999-4	1993	The site of increased tyrosine phosphorylation in Src family members was identified by comparison of cyanogen bromide peptide maps.	Cyanogen Bromide	101-117	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
8433999-5	1993	Phosphorylation of the C-terminal phosphopeptide, containing the negative regulatory site of tyrosine phosphorylation, from the CD45-deficient cells was increased 8-fold for p56lck and 2-fold for p59fyn.	Tyrosine	93-101	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	196-202
7678277-6	1993	These data suggest that tyrosine-phosphorylation of tubulin, in which Fyn and Lyn might involve, regulate monocytic differentiation through alteration of microtubule assembly.	Tyrosine	24-32	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
1385527-11	1992	This complex of DAF with src family protein tyrosine kinases requires the GPI anchor and suggests a pathway for signaling through GPI-anchored membrane proteins.	Glycosylphosphatidylinositols	74-77	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
8428589-3	1993	This site of tyrosine phosphorylation negatively regulates the function of the Src family of kinases.	Tyrosine	13-21	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
1465444-10	1992	Interestingly, this segment contains no tyrosine residues, although it is the phosphotyrosine-binding src homology domains of p59fyn and phosphatidylinositol 3-kinase which mediate their association with many growth factor receptors.	Phosphotyrosine	78-93	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	126-132
1464315-0	1992	CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.	Diglycerides	94-108	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-42
1464315-0	1992	CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.	Calcium	153-160	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-42
1385527-1	1992	Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1.	Glycosylphosphatidylinositols	15-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	92-98
1385527-11	1992	This complex of DAF with src family protein tyrosine kinases requires the GPI anchor and suggests a pathway for signaling through GPI-anchored membrane proteins.	Glycosylphosphatidylinositols	130-133	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
1371471-4	1992	The machinery which couples the TcR/CD3 complex, CD4, and CD45 to PI-PLC appears to involve regulation of tyrosine phosphorylation, as the TcR/CD3 and CD4 receptors are associated with the tyrosine kinases p59fyn and p56lck, respectively, and CD45 has intrinsic tyrosine phosphatase activity.	Tyrosine	106-114	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	206-212
1454062-8	1992	Stimulation of fyn activity implicates this kinase as a mediator of the tyrosine phosphorylation events originating from the TcR/CD3 complex.	Tyrosine	72-80	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
1373484-2	1992	Several recent studies have implicated non-receptor protein tyrosine kinase of the src family, especially p56lck and p59fyn, in mediating at least a portion of these tyrosine phosphorylation events.	Tyrosine	60-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-86
1373484-2	1992	Several recent studies have implicated non-receptor protein tyrosine kinase of the src family, especially p56lck and p59fyn, in mediating at least a portion of these tyrosine phosphorylation events.	Tyrosine	60-68	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	117-123
1987282-8	1991	The granulocytic differentiation of the cells treated with retinoic acid was accompanied by intense expression of fgr, but weak or no expression of lyn and fyn gene.	Tretinoin	59-72	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	156-159
1722201-1	1991	The functions of src family protein-tyrosine kinases are thought to be regulated negatively by the phosphorylation of highly conserved tyrosine residues close to their carboxyl termini.	Tyrosine	36-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	17-20
1722201-6	1991	The putative regulatory site, tyrosine 508, was found to be essential for phosphorylation in p56lyn, and the kinase activities of these src family kinases were repressed by phosphorylation with CSK.	Tyrosine	30-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	136-139
1530920-7	1992	They suggest that p59fyn is a crucial component of the TcR signal transduction machinery and that one of the earliest consequences of antigen recognition by the TcR is p59fyn-mediated phosphorylation of intracellular substrates on tyrosine residues.	Tyrosine	231-239	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-174
1724737-6	1991	Studies demonstrating physical association of p59lyn with the TCR implicate fyn as an important candidate for the TCR tyrosine kinase.	p59lyn	46-52	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
1712101-8	1991	Since other studies have implicated two members of the src family of PTKs in TCR-mediated signal transduction, our findings suggest that the induction of tyrosine phosphorylation of PLC-gamma 1 by a mechanism involving a src-like kinase may be the means by which the TCR regulates PLC activity in T cells.	Tyrosine	154-162	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	55-58
1712101-8	1991	Since other studies have implicated two members of the src family of PTKs in TCR-mediated signal transduction, our findings suggest that the induction of tyrosine phosphorylation of PLC-gamma 1 by a mechanism involving a src-like kinase may be the means by which the TCR regulates PLC activity in T cells.	Tyrosine	154-162	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	221-236
1987282-5	1991	In TPA-induced differentiation of HL-60 cells, both fyn and lyn genes, but not fgr gene, were expressed.	Tetradecanoylphorbol Acetate	3-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
1699196-4	1990	Phosphoamino acid analysis demonstrated that the fyn protein from IM-9 cells was phosphorylated in vivo predominantly on tyrosine and threonine with only a small amount of phosphoserine detected.	Threonine	134-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
1699196-3	1990	The fyn protein from IM-9 cells incorporated [3H]myristate in vivo and was found to be membrane associated.	Tritium	46-48	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	4-7
1699196-4	1990	Phosphoamino acid analysis demonstrated that the fyn protein from IM-9 cells was phosphorylated in vivo predominantly on tyrosine and threonine with only a small amount of phosphoserine detected.	Phosphoserine	172-185	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
1699196-4	1990	Phosphoamino acid analysis demonstrated that the fyn protein from IM-9 cells was phosphorylated in vivo predominantly on tyrosine and threonine with only a small amount of phosphoserine detected.	Phosphoamino Acids	0-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
1699196-5	1990	the major chymotryptic phosphopeptide of the fyn protein was phosphorylated exclusively on tyrosine.	Tyrosine	91-99	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
1699196-4	1990	Phosphoamino acid analysis demonstrated that the fyn protein from IM-9 cells was phosphorylated in vivo predominantly on tyrosine and threonine with only a small amount of phosphoserine detected.	Tyrosine	121-129	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	49-52
1699196-7	1990	These results provide direct evidence for phosphorylation of tyrosine-531 in the carboxy-terminal chymotryptic peptide of the fyn protein.	Tyrosine	61-69	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	126-129
1699196-7	1990	These results provide direct evidence for phosphorylation of tyrosine-531 in the carboxy-terminal chymotryptic peptide of the fyn protein.	Peptides	111-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	126-129
1699196-9	1990	Loss of the phosphorylation site at tyrosine-531 may similarly contribute to the transforming abilities of carboxy-terminal deletion mutants of the fyn protein.	Tyrosine	36-44	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	148-151
8823293-3	1996	Unexpectedly, the detection of Lck, Fyn, and ZAP-70 was reversed after the treatment of cell lysates with dithiothreitol.	Dithiothreitol	106-120	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
33807403-6	2021	Furthermore, pterostilbene markedly diminished Lyn, Fyn, and Syk phosphorylation and hydroxyl radical formation stimulated by collagen.	pterostilbene	13-26	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
33590779-7	2022	Moreover, the expression of FYN, a downstream target of integrin subunits, was up-regulated (7.4-fold by qPCR) in FxOH-treated PANC-1 cells.	fxoh	114-118	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	28-31
33590779-8	2022	These results suggest that FxOH accelerates the growth of PANC-1 cells by up-regulating the expression of integrin beta1, FAK, Paxillin, FYN, AKT, and PPARgamma.	fxoh	27-31	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
34531767-3	2021	Ethanol exposure upregulates Fyn, a protein tyrosine kinase that indirectly modulates NMDAR signaling by phosphorylating the NR2B subunit.	Ethanol	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
34959172-0	2022	ARN25068, a versatile starting point towards triple GSK-3beta/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.	arn25068	0-8	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	62-65
34959172-5	2022	Here, we report on the identification and characterization of ARN25068 (4), a low nanomolar and well-balanced dual GSK-3beta and FYN inhibitor, which also shows inhibitory activity against DYRK1A, an emerging target in AD and tauopathies.	arn25068	62-70	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-132
34856444-0	2022	Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3beta/Fyn pathway.	ru(ii)-isoquinoline	15-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
34856444-0	2022	Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3beta/Fyn pathway.	Cisplatin	54-63	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	137-140
34238111-3	2021	Herein, a new series of imidazo(4,5-c)pyridin-2-one derivatives were designed and synthesised as SFK inhibitors.	imidazo[4,5-c]pyridin-2-one	24-51	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	97-100
34475522-0	2022	Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder.	saracatinib	36-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-18
34475522-2	2022	Altered striatal regulation of the GluN2B subunit of N-methyl-D-aspartate (NMDA) glutamate receptors by the Fyn/Src family of protein tyrosine kinases has been implicated in animal alcohol consumption.	Alcohols	181-188	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-111
34798298-1	2022	OBJECTIVE: To observe the effect of AZD0530 on the progression of knee OA after blocking beta-catenin phosphorylation and then dormancy of the Wnt/beta pathway by tyrosine kinase Fyn.	saracatinib	36-43	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	179-182
34798298-9	2022	AZD0530 can inhibit tyrosine kinase Fyn from beta-catenin phosphorylation, a key Wnt/beta pathway protein, and then inhibit Wnt/beta pathway levels in chondrocytes.	saracatinib	0-7	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	36-39
34983908-0	2022	Hesperetin inhibits sphingosylphosphorylcholine-induced vascular smooth muscle contraction by regulating the Fyn/Rho-kinase pathway.	hesperetin	0-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
34983908-0	2022	Hesperetin inhibits sphingosylphosphorylcholine-induced vascular smooth muscle contraction by regulating the Fyn/Rho-kinase pathway.	sphingosine phosphorylcholine	20-47	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	109-112
34983908-6	2022	Hesperetin blocked the SPC-induced translocation of Fyn and ROK from the cytosol to the membrane in human coronary artery smooth muscle cells (HCASMCs).	hesperetin	0-10	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
34983908-7	2022	SPC decreased the phosphorylation level of Fyn at Y531 in both VSMs and HCASMCs and increased the phosphorylation levels of Fyn at Y420, myosin phosphatase target subunit 1 (MYPT1) at T853 and myosin light chain (MLC) at S19 in both VSMs and HCASMCs, which were significantly suppressed by hesperetin.	hesperetin	290-300	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	43-46
34983908-7	2022	SPC decreased the phosphorylation level of Fyn at Y531 in both VSMs and HCASMCs and increased the phosphorylation levels of Fyn at Y420, myosin phosphatase target subunit 1 (MYPT1) at T853 and myosin light chain (MLC) at S19 in both VSMs and HCASMCs, which were significantly suppressed by hesperetin.	hesperetin	290-300	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	124-127
34983908-8	2022	Our results indicate that hesperetin inhibits the SPC-induced contraction at least in part by suppressing the Fyn/ROK pathway, suggesting that hesperetin can be a novel drug to prevent and treat vasospasm.	hesperetin	26-36	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
34983908-8	2022	Our results indicate that hesperetin inhibits the SPC-induced contraction at least in part by suppressing the Fyn/ROK pathway, suggesting that hesperetin can be a novel drug to prevent and treat vasospasm.	hesperetin	143-153	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	110-113
34724245-5	2021	Surface plasmon resonance assay demonstrated direct binding between constitutively active Fyn (CA-Fyn) and N-terminus of paxillin (N-pax).	n-pax	131-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
34724245-5	2021	Surface plasmon resonance assay demonstrated direct binding between constitutively active Fyn (CA-Fyn) and N-terminus of paxillin (N-pax).	n-pax	131-136	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
34724245-7	2021	N-pax co-localized with CA-Fyn at the cytosol and overexpression of N-pax inhibited the SPC-induced actin stress fiber formation and cell migration, indicating that the direct binding of FL-pax and CA-Fyn at the ends of actin stress fibers is essential for the ROK-mediated actin stress fiber formation and cell migration.	n-pax	0-5	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
34724245-7	2021	N-pax co-localized with CA-Fyn at the cytosol and overexpression of N-pax inhibited the SPC-induced actin stress fiber formation and cell migration, indicating that the direct binding of FL-pax and CA-Fyn at the ends of actin stress fibers is essential for the ROK-mediated actin stress fiber formation and cell migration.	n-pax	0-5	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	201-204
34724245-7	2021	N-pax co-localized with CA-Fyn at the cytosol and overexpression of N-pax inhibited the SPC-induced actin stress fiber formation and cell migration, indicating that the direct binding of FL-pax and CA-Fyn at the ends of actin stress fibers is essential for the ROK-mediated actin stress fiber formation and cell migration.	n-pax	68-73	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	201-204
34724245-7	2021	N-pax co-localized with CA-Fyn at the cytosol and overexpression of N-pax inhibited the SPC-induced actin stress fiber formation and cell migration, indicating that the direct binding of FL-pax and CA-Fyn at the ends of actin stress fibers is essential for the ROK-mediated actin stress fiber formation and cell migration.	fl-pax	187-193	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
34724245-7	2021	N-pax co-localized with CA-Fyn at the cytosol and overexpression of N-pax inhibited the SPC-induced actin stress fiber formation and cell migration, indicating that the direct binding of FL-pax and CA-Fyn at the ends of actin stress fibers is essential for the ROK-mediated actin stress fiber formation and cell migration.	fl-pax	187-193	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	201-204
34589604-10	2021	Oral administration of saracatinib, a FYN kinase inhibitor, significantly suppressed formation of bone osteolytic lesions in a polyethylene debris-induced osteolysis model.	saracatinib	23-34	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	38-41
34315513-11	2021	Dasatinib and siRNA for Fyn and Yes was employed to inhibit SFKs and verify their role in increased migration and invasion in MCF7 cells treated with sublethal doses of Dox.	Doxorubicin	169-172	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
34315513-14	2021	Instead, sublethal Dox induces expression of multiple SFK-including Fyn, Yes, and Src-partly in a p53 and ATR-dependent manner.	Doxorubicin	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-57
34315513-14	2021	Instead, sublethal Dox induces expression of multiple SFK-including Fyn, Yes, and Src-partly in a p53 and ATR-dependent manner.	Doxorubicin	19-22	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	68-71
34315513-16	2021	Functionally, inhibiting SFKs with Dasatinib and specific downregulation of Fyn suppressed Dox-induced migration and invasion of MCF7 cells.	Doxorubicin	91-94	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
34326922-5	2021	Considering these, the objective of the current research was to determine (i) the involvement of Fyn in ER stress-mediated AKI and (ii) the effect of CO-releasing molecule-2 (CORM2) on reactive oxygen species- (ROS-) Fyn-ER stress-mediated AKI.	Reactive Oxygen Species	185-208	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	217-220
34137596-4	2021	Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay.	Proline	60-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
34137596-4	2021	Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay.	polyproline	97-108	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
34137596-4	2021	Here we show that binding of Fyn SH3, a small intracellular proline-binding domain, to the first polyproline tract of httex1Q35 inhibits fibril formation by both NMR and a thioflavin T fluorescence assay.	thioflavin T	172-184	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
35526051-12	2022	In addition, RNA binding protein immunoprecipitation (RIP) and anti- N6-methyladenosine immunoprecipitation (MeRIP) assays demonstrated that FYN mRNA was N6-methyladenosine (m6A) modified and bound with PA2G4, as well as YTHDF2.	N-methyladenosine	69-87	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
35174920-8	2022	Furthermore, CaFB upregulated Hck expression and downregulated Fyn expression.	calcium fructoborate	13-17	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	63-66
35617485-0	2022	Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells.	nanchangmycin	0-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	24-27
35526051-12	2022	In addition, RNA binding protein immunoprecipitation (RIP) and anti- N6-methyladenosine immunoprecipitation (MeRIP) assays demonstrated that FYN mRNA was N6-methyladenosine (m6A) modified and bound with PA2G4, as well as YTHDF2.	N-methyladenosine	154-172	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-144
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	pp2	62-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	225-228
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	pp2	62-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	381-384
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	Cocaine	104-111	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	225-228
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	Cocaine	279-286	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	225-228
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	Cocaine	306-313	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	225-228
35185557-4	2022	For this experiment, we administered the Src kinase inhibitor PP2 into the bilateral hippocampus before cocaine-CPP and self-administration training, and the results showed that pharmacological manipulation of the Src kinase Fyn activity significantly attenuated the response to cocaine-paired cues in the cocaine-CPP and self-administration paradigms, indicating that hippocampal Fyn activity contributes to cocaine-associated memory formation.	Cocaine	409-416	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	225-228
35185557-5	2022	In addition, the regulation of cocaine-associated memory formation by Fyn depends on Tau expression, as restoring Tau to normal levels disrupted cocaine memory formation.	Cocaine	31-38	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
35185557-5	2022	In addition, the regulation of cocaine-associated memory formation by Fyn depends on Tau expression, as restoring Tau to normal levels disrupted cocaine memory formation.	Cocaine	145-152	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	70-73
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	100-107	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	100-107	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	248-251
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	143-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	143-150	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	248-251
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	205-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	205-212	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	248-251
35185557-6	2022	Together, these results indicate that hippocampal Fyn activity plays a key role in the formation of cocaine-associated memory, which underlies cocaine-associated contextual stimulus-mediated regulation of cocaine-seeking behaviour, suggesting that Fyn represents a promising therapeutic target for weakening cocaine-related memory and treating cocaine addiction.	Cocaine	308-315	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53