PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23843187-3	2014	In this study, we found that TMEM16E was rapidly degraded via the proteasome pathway, which was rescued by inhibition of the PI3K pathway and by the chemical chaperone, sodium butyrate.	Butyric Acid	169-184	anoctamin 5	Homo sapiens	29-36
23843187-8	2014	In addition, the GDD-causing cysteine mutation made in TMEM16A drastically altered CaCC activity.	Cysteine	29-37	anoctamin 5	Homo sapiens	17-20
23047743-6	2013	To date, only two mutations on the same cysteine residue at position 356 of ANO5 amino-acid sequence have been described in GDD families.	Cysteine	40-48	anoctamin 5	Homo sapiens	76-80
15124103-4	2004	Two missense mutations (C356R and C356G) of GDD1 were identified in the two families with GDD (the original Japanese family and a new African American family), and both missense mutations occur at the cysteine residue at amino acid 356, which is evolutionarily conserved among human, mouse, zebrafish, fruit fly, and mosquito.	Cysteine	201-209	anoctamin 5	Homo sapiens	44-48
15124103-5	2004	Cellular localization to the endoplasmic reticulum suggests a role for GDD1 in the regulation of intracellular calcium homeostasis.	Calcium	111-118	anoctamin 5	Homo sapiens	71-75
33688936-3	2021	Here, we show that the ER helps clear this surge in cytoplasmic calcium through an ER-resident calcium pump, SERCA, and a calcium-activated ion channel, Anoctamin 5 (ANO5).	Calcium	64-71	anoctamin 5	Homo sapiens	153-164
34841576-3	2022	Here, we generated the first knock-in mouse model for GDD with the expression of human mutation p.Cys360Tyr in ANO5.	cys360tyr	98-107	anoctamin 5	Homo sapiens	111-115
35463132-5	2022	One patient was homozygous for a novel splice variant (c.294+5G>A; p.(Ala98Ins4*)) in ANO5.	ala98ins4	70-79	anoctamin 5	Homo sapiens	86-90
33688936-3	2021	Here, we show that the ER helps clear this surge in cytoplasmic calcium through an ER-resident calcium pump, SERCA, and a calcium-activated ion channel, Anoctamin 5 (ANO5).	Calcium	64-71	anoctamin 5	Homo sapiens	166-170
33688936-6	2021	ANO5 deficit in limb girdle muscular dystrophy 2L (LGMD2L) patient cells compromises their cytosolic and ER calcium homeostasis.	Calcium	108-115	anoctamin 5	Homo sapiens	0-4
33688936-6	2021	ANO5 deficit in limb girdle muscular dystrophy 2L (LGMD2L) patient cells compromises their cytosolic and ER calcium homeostasis.	Calcium	108-115	anoctamin 5	Homo sapiens	51-57
33688936-7	2021	By generating a mouse model of LGMD2L, we find that PM injury causes cytosolic calcium overload and compromises the ability of ANO5-deficient myofibers to repair.	Calcium	79-86	anoctamin 5	Homo sapiens	31-37
30996299-6	2019	The p.C356W mutation may damage the predicted protein stability of ANO5 by altering the structure of several extracellular loops of ANO5 and affecting the formation of the disulfide bond, thereby disrupting the correct folding of ANO5 protein.	Disulfides	172-181	anoctamin 5	Homo sapiens	67-71
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Cysteine	141-149	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Cysteine	141-149	anoctamin 5	Homo sapiens	30-34
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	N-acetylmethionine	182-191	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	N-acetylmethionine	182-191	anoctamin 5	Homo sapiens	30-34
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Serine	193-199	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Serine	193-199	anoctamin 5	Homo sapiens	30-34
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	DL-ALANINE	201-207	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	DL-ALANINE	201-207	anoctamin 5	Homo sapiens	30-34
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Cysteine	141-148	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	Cysteine	141-148	anoctamin 5	Homo sapiens	30-34
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	DL-Glutamine	220-228	anoctamin 5	Homo sapiens	21-28
32517157-5	2020	Here, we report that TMEM16E (ANO5), -H (ANO8), -J (ANO9) and K (ANO10) are targeted to the plasma membrane when fused to a C-terminal CAAX (cysteine, two aliphatic amino acids plus methionin, serine, alanin, cystein or glutamin) motif.	DL-Glutamine	220-228	anoctamin 5	Homo sapiens	30-34
31680776-0	2019	Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes.	Calcium	80-84	anoctamin 5	Homo sapiens	14-25
31680776-0	2019	Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes.	Calcium	80-84	anoctamin 5	Homo sapiens	26-33
31680776-2	2019	However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane chloride channel.	Chlorides	86-94	anoctamin 5	Homo sapiens	42-46
31680776-8	2019	ANO5-KD impaired depolarization-induced [Ca2+]i transient and reduced sarcoplasmic reticulum (SR) Ca2+ storage.	Calcium	41-45	anoctamin 5	Homo sapiens	0-4
31680776-8	2019	ANO5-KD impaired depolarization-induced [Ca2+]i transient and reduced sarcoplasmic reticulum (SR) Ca2+ storage.	Calcium	98-102	anoctamin 5	Homo sapiens	0-4
31680776-9	2019	ANO5-KD resulted in reduced protein expression of the dihydropyridine receptor (DHPR) and SR Ca2+-ATPase subtype 1.	Calcium	93-97	anoctamin 5	Homo sapiens	0-4
31680776-10	2019	In addition, ANO5-KD compromised co-localization between DHPR and ryanodine receptor subtype 1.	Ryanodine	66-75	anoctamin 5	Homo sapiens	13-17
31680776-11	2019	It is concluded that ANO5-KD causes nuclear positioning defect by reduction of Kif5b expression, and compromises Ca2+ signaling by downregulating the expression of DHPR and SERCA proteins.	Calcium	113-117	anoctamin 5	Homo sapiens	21-25
31341644-0	2019	Dysregulated calcium homeostasis prevents plasma membrane repair in Anoctamin 5/TMEM16E-deficient patient muscle cells.	Calcium	13-20	anoctamin 5	Homo sapiens	68-79
31341644-0	2019	Dysregulated calcium homeostasis prevents plasma membrane repair in Anoctamin 5/TMEM16E-deficient patient muscle cells.	Calcium	13-20	anoctamin 5	Homo sapiens	80-87
29124309-3	2018	We show here that human TMEM16E, when overexpressed in mammalian cell lines, displayed partial plasma membrane localization and gave rise to phospholipid scrambling (PLS) as well as non-selective ionic currents with slow time-dependent activation at highly depolarized membrane potentials.	Phospholipids	141-153	anoctamin 5	Homo sapiens	24-31
30257928-3	2018	Here, we show that heterologous overexpression of ANO5 confers Ca2+-dependent phospholipid scrambling to HEK-293 cells and that scrambling is associated with the simultaneous development of a nonselective ionic current.	Phospholipids	78-90	anoctamin 5	Homo sapiens	50-54