PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
17187402-4	2007	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	84-88
19112848-6	2008	Alcohol was found to down-regulate hepcidin expression in the liver leading to elevated expression of the iron transporter proteins, DMT1 and ferroportin in the duodenum.	Alcohols	0-7	doublesex and mab-3 related transcription factor 1	Homo sapiens	133-137
19083439-9	2008	The DMT1 mRNA expression was upregulated time-dependently but not concentration-dependently in the late TPEN treatment duration.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	104-108	doublesex and mab-3 related transcription factor 1	Homo sapiens	4-8
18330026-4	2008	The pathophysiology of the deficiency, clinical features, laboratory findings, diagnosis and treatment are discussed as well as the basic findings of iron absorption mechanism in which the newly found factors such as DMT-1 and hepcidin are involved.	Iron	150-154	doublesex and mab-3 related transcription factor 1	Homo sapiens	217-222
17459496-7	2007	In addition, in vitro docking or nuclear transport assay in digitonin-permeabilized cells shows that DMRT1 is docked at the nuclear pore complex (NPC) or accumulated in the nucleus when importin-beta1, but not importin-alpha1 added.	Digitonin	60-69	doublesex and mab-3 related transcription factor 1	Homo sapiens	101-106
16790587-0	2006	DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis.	Iron	85-89	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
17002471-10	2006	Because BPDS binds Fe2+ but not Fe3+ and because only Fe2+ is transported by DMT-1, the finding that BPDS inhibited uptake from NaFeEDTA suggests that at least some iron dissociates from EDTA and is reduced just as simple inorganic iron at the brush border membrane of the enterocyte.	ammonium ferrous sulfate	54-58	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-82
17002471-10	2006	Because BPDS binds Fe2+ but not Fe3+ and because only Fe2+ is transported by DMT-1, the finding that BPDS inhibited uptake from NaFeEDTA suggests that at least some iron dissociates from EDTA and is reduced just as simple inorganic iron at the brush border membrane of the enterocyte.	Fe(III)-EDTA	128-136	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-82
17002471-10	2006	Because BPDS binds Fe2+ but not Fe3+ and because only Fe2+ is transported by DMT-1, the finding that BPDS inhibited uptake from NaFeEDTA suggests that at least some iron dissociates from EDTA and is reduced just as simple inorganic iron at the brush border membrane of the enterocyte.	Iron	165-169	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-82
16904349-4	2006	The preincubation in iron-free medium resulted in a slight decrease (20%) of DMT1 mRNA level.	Iron	21-25	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-81
16630119-2	2006	After stimulation with 50 nM phorbol 12-myristate 13-acetate (PMA), the cells differentiated into cells with mesenchymal characteristics and upregulated Dmrt-1 mRNA, possibly through the protein kinase C/mitogen-activated protein kinase/activated protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	29-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	153-159
16439678-0	2006	Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload.	Iron	99-103	doublesex and mab-3 related transcription factor 1	Homo sapiens	14-18
16439678-1	2006	DMT1 mediates the pH-dependent uptake of Fe(2+) from the diet in duodenal enterocytes and in most other cells.	ammonium ferrous sulfate	41-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
16439678-4	2006	We report a compound heterozygote for 2 new DMT1 mutations, associated with microcytic anemia from birth and progressive liver iron overload.	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	44-48
16630119-2	2006	After stimulation with 50 nM phorbol 12-myristate 13-acetate (PMA), the cells differentiated into cells with mesenchymal characteristics and upregulated Dmrt-1 mRNA, possibly through the protein kinase C/mitogen-activated protein kinase/activated protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	62-65	doublesex and mab-3 related transcription factor 1	Homo sapiens	153-159
14534366-1	2003	[Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt = 2",6"-dimethyltyrosine) binds with high affinity and selectivity to the mu opioid receptor and is a surprisingly potent and long-acting analgesic, especially after intrathecal administration.	h-dmt-d-arg	13-24	doublesex and mab-3 related transcription factor 1	Homo sapiens	1-5
15631519-3	2005	Iron-loaded Caco-2 cells, with reduced DMT-1 and elevated HFE mRNA levels, down-regulated uptake from ferrous ascorbate and bisglycinate but not from ferric compounds.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	39-44
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	25-29	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
14972659-3	2004	In recent years, several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized.	Iron	58-62	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
16629174-3	2006	Studies were initiated to examine potential interactions of other metal ions with Fe(II) via DMT1.	ammonium ferrous sulfate	82-88	doublesex and mab-3 related transcription factor 1	Homo sapiens	93-97
16629174-8	2006	We conclude that vesicular transport, involving endo- and exocytosis at both ends of the enterocyte, is a fundamental aspect of intestinal iron absorption and that DMT1 may function as a transporter not just for divalent but also for monovalent metal ions.	Metals	245-250	doublesex and mab-3 related transcription factor 1	Homo sapiens	164-168
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	89-93	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16629175-3	2006	Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione.	Iron	173-177	doublesex and mab-3 related transcription factor 1	Homo sapiens	259-263
16330325-4	2005	Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	84-88
15223008-3	2004	Divalent metal transport protein (DMT1) on the apical surface of duodenal enterocytes is recognised as the major iron import protein.	Iron	113-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	34-38
15223008-4	2004	We investigated whether genetic variability within the DMT1 gene may partly explain the phenotypic variability seen amongst a group of C282Y homozygotes with iron overload.	Iron	158-162	doublesex and mab-3 related transcription factor 1	Homo sapiens	55-59
14534366-1	2003	[Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt = 2",6"-dimethyltyrosine) binds with high affinity and selectivity to the mu opioid receptor and is a surprisingly potent and long-acting analgesic, especially after intrathecal administration.	phe-lys-nh2	25-36	doublesex and mab-3 related transcription factor 1	Homo sapiens	1-5
14534366-1	2003	[Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt = 2",6"-dimethyltyrosine) binds with high affinity and selectivity to the mu opioid receptor and is a surprisingly potent and long-acting analgesic, especially after intrathecal administration.	2',6'-dimethyltyrosine	44-66	doublesex and mab-3 related transcription factor 1	Homo sapiens	1-5
14534366-2	2003	In an attempt to better understand the unique pharmacological profile of [Dmt1]DALDA, we have prepared [3H][Dmt1]DALDA and compared its binding properties with that of [3H]DAMGO ([d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin).	Tritium	104-106	doublesex and mab-3 related transcription factor 1	Homo sapiens	108-112
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	Adenosine Monophosphate	12-15	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
14534366-4	2003	Dissociation of [3H][Dmt1]DALDA was also rapid (K(-1) = 0.032 min(-1)) and indicated binding to a single site.	Tritium	17-19	doublesex and mab-3 related transcription factor 1	Homo sapiens	21-25
14534366-5	2003	[3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5"-(beta,gamma-imido)triphosphate].	Tritium	1-3	doublesex and mab-3 related transcription factor 1	Homo sapiens	5-9
14534366-5	2003	[3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5"-(beta,gamma-imido)triphosphate].	Sodium	130-136	doublesex and mab-3 related transcription factor 1	Homo sapiens	5-9
14534366-5	2003	[3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5"-(beta,gamma-imido)triphosphate].	Guanylyl Imidodiphosphate	155-198	doublesex and mab-3 related transcription factor 1	Homo sapiens	5-9
14534366-9	2003	The Ki values for a number of opioid ligands were generally higher when determined by competitive displacement binding against [3H][Dmt1]DALDA compared with [3H]DAMGO, with the exception of Dmt1-substituted peptide analogs.	Tritium	128-130	doublesex and mab-3 related transcription factor 1	Homo sapiens	132-136
14534366-11	2003	[35S]GTPgammaS (guanosine 5"-O -(3-[35S]thio)triphosphate) binding showed that [Dmt1]DALDA and DAMGO are full agonists at hMOR and hDOR but are only partial agonists at hKOR.	Sulfur-35	1-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	80-84
14534366-11	2003	[35S]GTPgammaS (guanosine 5"-O -(3-[35S]thio)triphosphate) binding showed that [Dmt1]DALDA and DAMGO are full agonists at hMOR and hDOR but are only partial agonists at hKOR.	guanosine 5"-o -(3-[35s]thio)triphosphate	16-57	doublesex and mab-3 related transcription factor 1	Homo sapiens	80-84
14534366-12	2003	The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors.	Tritium	43-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
14534366-12	2003	The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors.	Tritium	43-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	170-174
14534366-12	2003	The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors.	Tritium	166-168	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
14534366-12	2003	The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors.	Tritium	166-168	doublesex and mab-3 related transcription factor 1	Homo sapiens	170-174
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	Metals	85-90	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	ammonium ferrous sulfate	96-100	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	Zinc	102-106	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	cupric ion	108-112	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
12973678-1	2003	BACKGROUND & AIMS: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+.	Manganese(2+)	117-121	doublesex and mab-3 related transcription factor 1	Homo sapiens	23-27
12973678-2	2003	Although DMT1 has been functionally linked to duodenal absorption and cellular utilisation of iron hardly anything is known about its distribution and potential role within the human glandular system.	Iron	94-98	doublesex and mab-3 related transcription factor 1	Homo sapiens	9-13
12973678-6	2003	CONCLUSIONS: Our results suggest that DMT1 may be of pivotal importance for the regulation of metal ion homeostasis within organs involved in absorption and excretion of ions.	Metals	94-99	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-42
12949888-0	2003	Localization of the iron transport proteins Mobilferrin and DMT-1 in the duodenum: the surprising role of mucin.	Iron	20-24	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-65
12949888-1	2003	There are two pathways for inorganic iron uptake in the intestine, the ferric pathway, mediated by the key protein mobilferrin, and the ferrous pathway, mediated by DMT-1.	Iron	37-41	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-170
12949888-7	2003	In iron-deficient animals both DMT-1 and Mobilferrin were concentrated in the apical surface of the villae.	Iron	3-7	doublesex and mab-3 related transcription factor 1	Homo sapiens	31-36
12547224-7	2002	Ferrous iron uptake is facilitated by a DMT-1 pathway which is shared with manganese.	Iron	0-12	doublesex and mab-3 related transcription factor 1	Homo sapiens	40-45
12572663-13	2003	In our ectopic expression assay for metal uptake, four metals--Fe2+, Mn2+, Ni2+ and Co2+--respond to the normal DMT1 cDNA but not the G185R mutant.	Metals	36-41	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
12572663-13	2003	In our ectopic expression assay for metal uptake, four metals--Fe2+, Mn2+, Ni2+ and Co2+--respond to the normal DMT1 cDNA but not the G185R mutant.	ammonium ferrous sulfate	63-67	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
12572663-13	2003	In our ectopic expression assay for metal uptake, four metals--Fe2+, Mn2+, Ni2+ and Co2+--respond to the normal DMT1 cDNA but not the G185R mutant.	Manganese(2+)	69-73	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
12572663-13	2003	In our ectopic expression assay for metal uptake, four metals--Fe2+, Mn2+, Ni2+ and Co2+--respond to the normal DMT1 cDNA but not the G185R mutant.	Nickel(2+)	75-79	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
12572663-13	2003	In our ectopic expression assay for metal uptake, four metals--Fe2+, Mn2+, Ni2+ and Co2+--respond to the normal DMT1 cDNA but not the G185R mutant.	Cobalt(2+)	84-88	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
12572663-16	2003	In rodent mutants, Fe and Mn appear more dependent on DMT1 than Cu and Zn.	Iron	19-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	54-58
15058014-14	2003	Age, lipid abnormalities, smoking and alcohol consumption, family history were associated with varying degrees of DMT1 complications.	Alcohols	38-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	114-118
12547224-7	2002	Ferrous iron uptake is facilitated by a DMT-1 pathway which is shared with manganese.	Manganese	75-84	doublesex and mab-3 related transcription factor 1	Homo sapiens	40-45
12547224-8	2002	In the iron deficient gut, large quantities of both mobilferrin and DMT-1 are found in goblet cells and intraluminal mucins suggesting that they are secreted with mucin into the intestinal lumen to bind iron to facilitate uptake by the cells.	Iron	7-11	doublesex and mab-3 related transcription factor 1	Homo sapiens	68-73
12547224-8	2002	In the iron deficient gut, large quantities of both mobilferrin and DMT-1 are found in goblet cells and intraluminal mucins suggesting that they are secreted with mucin into the intestinal lumen to bind iron to facilitate uptake by the cells.	Iron	203-207	doublesex and mab-3 related transcription factor 1	Homo sapiens	68-73
11933019-2	2002	However, it was not until recently with the identification and characterization of several new genes related to iron homeostasis, such as the hemochromatosis protein HFE and the iron transporter DMT1, that our knowledge has been advanced dramatically.	Iron	112-116	doublesex and mab-3 related transcription factor 1	Homo sapiens	195-199
12427107-4	2002	Novel genes associated with iron uptake include Dcytb, a putative iron-regulated reductase and DMT1, a Fe(II) carrier in the brush border membrane.	Iron	28-32	doublesex and mab-3 related transcription factor 1	Homo sapiens	95-99
12427107-4	2002	Novel genes associated with iron uptake include Dcytb, a putative iron-regulated reductase and DMT1, a Fe(II) carrier in the brush border membrane.	ammonium ferrous sulfate	103-109	doublesex and mab-3 related transcription factor 1	Homo sapiens	95-99
11933019-4	2002	Iron is released from transferrin as the result of the acidic pH in endosome and then is transported to the cytosol by DMT1.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	119-123
12139399-2	2002	Dietary iron enters the intestinal epithelium via the brush-border transporter DMT1 and exits through the basolateral membranes.	Iron	8-12	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
12139399-6	2002	This, in turn, modulates the intracellular iron content of mature epithelial cells, which ultimately determines the activity of the brush-border transporter DMT1.	Iron	43-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	157-161
33232715-5	2021	Heme iron is incorporated into cells through HCP1, and non-heme iron is transported by DMT1 in absorptive cells.	Heme	59-63	doublesex and mab-3 related transcription factor 1	Homo sapiens	87-91
11875282-1	2001	We have studied by immunocytochemistry, the distribution of DMT-1, a cellular iron transporter responsible for transport of metal irons from the plasma membrane to endosomes, in the normal monkey cerebral neocortex and hippocampus.	Metals	124-129	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-65
11875282-1	2001	We have studied by immunocytochemistry, the distribution of DMT-1, a cellular iron transporter responsible for transport of metal irons from the plasma membrane to endosomes, in the normal monkey cerebral neocortex and hippocampus.	Iron	130-135	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-65
11875282-6	2001	The observation that DMT-1 was present on astrocytic endfeet suggests that these cells are involved in uptake of iron from endothelial cells.	Iron	113-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	21-26
11093950-8	2000	Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues.	Histidine	104-113	doublesex and mab-3 related transcription factor 1	Homo sapiens	50-54
10865496-4	2000	The resulting hyperabsorption, which forms the basis of iron overload in hemochromatosis, is likely to implicate an overexpression of the transmembrane iron carrier DMT1.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-169
10865496-4	2000	The resulting hyperabsorption, which forms the basis of iron overload in hemochromatosis, is likely to implicate an overexpression of the transmembrane iron carrier DMT1.	Iron	152-156	doublesex and mab-3 related transcription factor 1	Homo sapiens	165-169
27420126-2	2001	These include two molecules involved in brush border iron uptake, the ferric reductase DcytB and the iron transporter DMT1, and two mediating iron transfer to the body, the iron transporter Ireg1 and the ferroxidase hephaestin (Hp).	Iron	101-105	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
27420126-4	2001	Evidence suggests that the block to absorption that follows a priming dose of iron is the result of elevated intracellular iron levels decreasing the expression of the brush border iron transporter DMT1.	Iron	78-82	doublesex and mab-3 related transcription factor 1	Homo sapiens	198-202
27420126-4	2001	Evidence suggests that the block to absorption that follows a priming dose of iron is the result of elevated intracellular iron levels decreasing the expression of the brush border iron transporter DMT1.	Iron	123-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	198-202
27420126-6	2001	In this model, DMT1 expression, and hence, brush border uptake, is regulated by local iron levels that are, in turn, determined by the rate of basolateral transfer.	Iron	86-90	doublesex and mab-3 related transcription factor 1	Homo sapiens	15-19
11093950-3	2000	The process of iron transport was studied by transfection of human DMT1 into the COS-7 cell line.	Iron	15-19	doublesex and mab-3 related transcription factor 1	Homo sapiens	67-71
11093950-4	2000	Native and epitope-tagged human DMT1 led to increased iron uptake.	Iron	54-58	doublesex and mab-3 related transcription factor 1	Homo sapiens	32-36
11093950-6	2000	The pH optimum of human DMT1 iron uptake was 6.75, which is equivalent to the pH of the duodenal brush border.	Iron	29-33	doublesex and mab-3 related transcription factor 1	Homo sapiens	24-28
11093950-8	2000	Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues.	Diethyl Pyrocarbonate	0-20	doublesex and mab-3 related transcription factor 1	Homo sapiens	50-54
11093950-8	2000	Diethylpyrocarbonate inhibition of iron uptake in DMT1-transfected cells suggests a functional role for histidine residues.	Iron	35-39	doublesex and mab-3 related transcription factor 1	Homo sapiens	50-54
33232715-5	2021	Heme iron is incorporated into cells through HCP1, and non-heme iron is transported by DMT1 in absorptive cells.	Iron	64-68	doublesex and mab-3 related transcription factor 1	Homo sapiens	87-91
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	43-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34596731-4	2021	Reduction of Fe(III) by ascorbate is important for cellular uptake of iron via DMT1.	ferric sulfate	13-20	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34596731-4	2021	Reduction of Fe(III) by ascorbate is important for cellular uptake of iron via DMT1.	Ascorbic Acid	24-33	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34596731-4	2021	Reduction of Fe(III) by ascorbate is important for cellular uptake of iron via DMT1.	Iron	70-74	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
34732689-6	2021	GSK-3beta KD antagonizes the expression of iron metabolic components including DMT1, FTH1, and FTL, leading to the disruption of iron homeostasis and decline in intracellular labile free iron level.	Iron	129-133	doublesex and mab-3 related transcription factor 1	Homo sapiens	79-83
35204067-8	2022	As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women.	Iron	7-11	doublesex and mab-3 related transcription factor 1	Homo sapiens	60-64
35104581-7	2022	Notably, Ven-PegC treatment increased the RNA translation and protein level of Tribbles homolog 3 (TRIB3), eukaryotic translation initiation factor 3 subunit C (eIF3C), doublesex and mab-3 related transcription factor 1 (DMRT1), salt inducible kinase 1 (SIK1).	ven-pegc	9-17	doublesex and mab-3 related transcription factor 1	Homo sapiens	169-219
35104581-7	2022	Notably, Ven-PegC treatment increased the RNA translation and protein level of Tribbles homolog 3 (TRIB3), eukaryotic translation initiation factor 3 subunit C (eIF3C), doublesex and mab-3 related transcription factor 1 (DMRT1), salt inducible kinase 1 (SIK1).	ven-pegc	9-17	doublesex and mab-3 related transcription factor 1	Homo sapiens	221-226
33597821-10	2021	Iron trafficking associated with the efflux protein ferroportin and influx protein divalent metal transporter (DMT)1 was affected differently in all three cell types.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	92-116
34012440-12	2021	This was accompanied by reduced expression of DMT-1, an iron transport protein.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	46-51
32621410-2	2020	It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(DMT1), transferrin receptor 1(TFR1), transferrin receptor 2(TFR2), ferroportin(FPN), hepcidin(HAMP), hemojuvelin(HJV) and Ferritin H. Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis.	Iron	17-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
31693761-9	2020	Inhibition of the iron transporter DMT1 protected IMG cells against Abeta-induced inflammation.	Iron	18-22	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	53-57	doublesex and mab-3 related transcription factor 1	Homo sapiens	124-128
31693761-10	2020	Potentiation of Abeta-elicited IL-1beta induction by iron was also antagonized by ROS inhibitors, supporting the model that DMT1-mediated iron loading and subsequent increase in ROS contribute to the inflammatory effects of Abeta in microglia.	Iron	138-142	doublesex and mab-3 related transcription factor 1	Homo sapiens	124-128
32621410-6	2020	Additional reports showed that miRNA can also modulate iron absorption, transport, storage and utilization via downregulation of DMT1, FPN, TFR1, TFR2, Ferritin H and other genes.	Iron	55-59	doublesex and mab-3 related transcription factor 1	Homo sapiens	129-133
29911470-4	2019	Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release.	Iron	177-181	doublesex and mab-3 related transcription factor 1	Homo sapiens	162-166
32365707-5	2020	In vitro binding and functional assays revealed the same rank order with KGOP01 > [Dmt1]DALDA > DAMGO > DALDA for both binding and MOR activation.	tyrosyl-arginyl-phenylalanyl-lysinamide	88-93	doublesex and mab-3 related transcription factor 1	Homo sapiens	83-87
32365707-7	2020	The Dmt (2",6"-dimethyl-L-Tyr) moiety of [Dmt1]DALDA and KGOP01 was found to represent the driving force for their high potency and agonist activity at the MOR.	dmt	4-7	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46
32365707-7	2020	The Dmt (2",6"-dimethyl-L-Tyr) moiety of [Dmt1]DALDA and KGOP01 was found to represent the driving force for their high potency and agonist activity at the MOR.	2",6"-dimethyl-l-tyr	9-29	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46
32365707-7	2020	The Dmt (2",6"-dimethyl-L-Tyr) moiety of [Dmt1]DALDA and KGOP01 was found to represent the driving force for their high potency and agonist activity at the MOR.	tyrosyl-arginyl-phenylalanyl-lysinamide	47-52	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46
31973819-7	2020	Conversely, TPEN, a chelator of zinc, inhibited iron uptake, DMT1, HEPH and FPN1 mRNA and protein expression.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	12-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	61-65
31973819-1	2020	In previous studies we demonstrated that zinc stimulates iron uptake in intestinal Caco-2 cells via Zinc-PI3K-IRP2-DMT1 axis.	Iron	57-61	doublesex and mab-3 related transcription factor 1	Homo sapiens	115-119
31973819-4	2020	LY294002, an inhibitor of PI3K, inhibited the zinc-induced iron transport, DMT1, HEPH mRNA and protein expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	doublesex and mab-3 related transcription factor 1	Homo sapiens	75-79
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Deferoxamine	0-12	doublesex and mab-3 related transcription factor 1	Homo sapiens	49-53
30980893-8	2019	Approximately 2.7 kb of the 5" upstream region of gsdf was cloned from the spotted scat genomic DNA and in silico promoter analysis revealed the putative transcription factor binding sites of Dmrt1 and Sf1.	gsdf	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	192-197
30980893-9	2019	The luciferase reporter assay, using the human embryonic kidney cells, demonstrated that Dmrt1 activated gsdf expression in a dose-dependent manner in the presence of Sf1 in spotted scat.	gsdf	105-109	doublesex and mab-3 related transcription factor 1	Homo sapiens	89-94
30980893-10	2019	These results suggest that Gsdf could play a role in regulating the development of spermatogonia and oogonia, and also participate in male sex differentiation by acting as a downstream gene of Dmrt1 in spotted scat.	gsdf	27-31	doublesex and mab-3 related transcription factor 1	Homo sapiens	193-198
31213851-11	2019	Conclusion: We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K/AKT signaling pathway in aggressive TNBCs.	Iron	99-103	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-81
31597263-1	2019	In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating the expression levels of TfR1 and DMT1 and exacerbated the migration of triple-negative breast cancer cells.	Deferoxamine	23-35	doublesex and mab-3 related transcription factor 1	Homo sapiens	125-129
31597263-1	2019	In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating the expression levels of TfR1 and DMT1 and exacerbated the migration of triple-negative breast cancer cells.	Deferoxamine	37-40	doublesex and mab-3 related transcription factor 1	Homo sapiens	125-129
31597263-1	2019	In our previous study, Deferoxamine (DFO) increased the iron concentration by upregulating the expression levels of TfR1 and DMT1 and exacerbated the migration of triple-negative breast cancer cells.	Iron	56-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	125-129
31213851-0	2019	Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway.	Iron	63-67	doublesex and mab-3 related transcription factor 1	Homo sapiens	49-53
31213851-7	2019	Results: In this study, we found that DFO treatment significantly increased the levels of iron uptake proteins, DMT1 and TfR1, in aggressive TNBCs.	Deferoxamine	38-41	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
31213851-7	2019	Results: In this study, we found that DFO treatment significantly increased the levels of iron uptake proteins, DMT1 and TfR1, in aggressive TNBCs.	Iron	90-94	doublesex and mab-3 related transcription factor 1	Homo sapiens	112-116
31213851-8	2019	Moreover, both TfR1 and DMT1 expressed on cell membrane were involved in high iron uptake in TNBCs under DFO-induced iron deficient condition.	Iron	78-82	doublesex and mab-3 related transcription factor 1	Homo sapiens	24-28
31213851-8	2019	Moreover, both TfR1 and DMT1 expressed on cell membrane were involved in high iron uptake in TNBCs under DFO-induced iron deficient condition.	Deferoxamine	105-108	doublesex and mab-3 related transcription factor 1	Homo sapiens	24-28
31213851-10	2019	The activated IL-6/PI3K/AKT pathway upregulated the expression of iron-uptake related proteins, TfR1 and DMT1, leading to increased iron uptakes.	Iron	132-136	doublesex and mab-3 related transcription factor 1	Homo sapiens	105-109
31213851-11	2019	Conclusion: We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K/AKT signaling pathway in aggressive TNBCs.	Deferoxamine	33-36	doublesex and mab-3 related transcription factor 1	Homo sapiens	77-81
30316781-6	2019	A growing body of literature indicates that NTBI uptake is mediated by non-transferrin-bound iron transporters such as ZIP14, L-type and T-type calcium channels, DMT1, ZIP8, and TRPC6.	ntbi	44-48	doublesex and mab-3 related transcription factor 1	Homo sapiens	162-166
30291234-2	2018	Here, three CDPS-containing loci (dmt1-3) are discovered by genome mining and comparative genome analysis of Streptomyces strains.	cdps	12-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	34-38
28884360-8	2018	The mix of Ca, Zn and Fe increased DMT1 and ferroportin expression mainly under high Zn concentration.	Zinc	15-17	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
28884360-8	2018	The mix of Ca, Zn and Fe increased DMT1 and ferroportin expression mainly under high Zn concentration.	Zinc	85-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	35-39
30809110-8	2019	Here, we review the multiple cell-damaging responses generated by the unregulated iron/calcium self-feeding cycle, such as excitotoxicity, free radical-mediated lipid peroxidation, and the oxidative modification of crucial components of iron and calcium homeostasis/signaling: the iron transporter DMT1, plasma membrane, and intracellular calcium channels and pumps.	Iron	82-86	doublesex and mab-3 related transcription factor 1	Homo sapiens	298-302
30809110-8	2019	Here, we review the multiple cell-damaging responses generated by the unregulated iron/calcium self-feeding cycle, such as excitotoxicity, free radical-mediated lipid peroxidation, and the oxidative modification of crucial components of iron and calcium homeostasis/signaling: the iron transporter DMT1, plasma membrane, and intracellular calcium channels and pumps.	Calcium	87-94	doublesex and mab-3 related transcription factor 1	Homo sapiens	298-302
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	cdps	12-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Valine	109-112	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Proline	114-117	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Leucine	119-122	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Isoleucine	124-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Alanine	132-135	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30291234-5	2018	Characterization of dmt1-3 unravels that CDPS-dependent machinery is involved in CDPS-synthesized DKP formation followed by tailoring steps of prenylation and cyclization to afford terpenylated DKP compounds drimentines.	cdps	41-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	20-24
30291234-5	2018	Characterization of dmt1-3 unravels that CDPS-dependent machinery is involved in CDPS-synthesized DKP formation followed by tailoring steps of prenylation and cyclization to afford terpenylated DKP compounds drimentines.	cdps	81-85	doublesex and mab-3 related transcription factor 1	Homo sapiens	20-24
30291234-5	2018	Characterization of dmt1-3 unravels that CDPS-dependent machinery is involved in CDPS-synthesized DKP formation followed by tailoring steps of prenylation and cyclization to afford terpenylated DKP compounds drimentines.	drimentines	208-219	doublesex and mab-3 related transcription factor 1	Homo sapiens	20-24
28762519-7	2018	We further detected increased levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1 + IRE) in IA testes, whereas the increasing trend of iron exporter ferroportin 1 (FPN1) was not statistically significant.	Iron	88-92	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
28762519-7	2018	We further detected increased levels of iron importer divalent metal transporter 1 with iron responsive element (DMT1 + IRE) in IA testes, whereas the increasing trend of iron exporter ferroportin 1 (FPN1) was not statistically significant.	Iron	40-44	doublesex and mab-3 related transcription factor 1	Homo sapiens	113-117
30115430-6	2018	Beside sideroblastic anemias, a number of other anemias can develop due to mutations of key proteins acting either on cellular iron transport (such as the DMT1 transporter), plasma iron transport (transferrin), and iron recycling (ceruloplasmin).	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	155-159
26251460-15	2015	In cultured fetal ovaries treated with RA, an increased number of meiotic germ cells (P < 0.05) and DMRT1-positive oogonia initiating meiosis (P < 0.05) was observed, which is in agreement with a previous study.	Tretinoin	39-41	doublesex and mab-3 related transcription factor 1	Homo sapiens	103-108
27729173-7	2017	RESULTS: In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1.	Iron	127-131	doublesex and mab-3 related transcription factor 1	Homo sapiens	144-148
28827515-7	2017	RESULTS Statistical analysis of the miRNAs expressions selected for further study the miR-31, miR-133a, miR-141, miR-145, miR-149, and miR-182, which are involved in the posttranscriptional expression of iron-related genes: TF, TFRI, DMT1, FTL, and FPN1.	Iron	204-208	doublesex and mab-3 related transcription factor 1	Homo sapiens	234-238
28840060-9	2017	While in H2O2 treated SH-SY5Y cells, the increased iron uptake and reduced iron release, in correlation with levels of DMT1(-IRE) and ferroportin 1, resulted in heavy iron accumulation, the FtMt overexpressing cells didn"t show any significant changes in levels of iron transport proteins and in the level of LIP.	Hydrogen Peroxide	9-13	doublesex and mab-3 related transcription factor 1	Homo sapiens	119-123
28072870-11	2017	The model obtained is a function of time and the initial apical iron concentration, with a linear component that captures the global tendency of the system, and a non-linear component that can be associated to the movement of DMT1 transporters.	Iron	64-68	doublesex and mab-3 related transcription factor 1	Homo sapiens	226-230
27714044-12	2016	Expression of Dmt1 (the iron importer), Dcytb (an apical membrane ferrireductase) and Fpn1 (the iron exporter) was decreased in Atp7a knockdown (KD) cells.	Iron	24-28	doublesex and mab-3 related transcription factor 1	Homo sapiens	14-18
27262439-9	2016	Notably, macrophages, eosinophils and neutrophils exhibited significantly increased catalytic Fe(II) with increased DMT1 expression and decreased ferritin expression, though catalytic Fe(II) was significantly decreased in the peritoneal lavage fluid.	ammonium ferrous sulfate	94-100	doublesex and mab-3 related transcription factor 1	Homo sapiens	116-120
26948688-3	2016	Both photoprobes effectively entered HeLa cells (and the nucleus) and were dependent on the tetracysteine motif in recombinant DMRT1 (doublesex and Mab3-related transcription factor) to induce fluorescence, suggesting that their crosslinking abilities can be exploited for the identification of nucleic acids and proteins associated with a protein of interest.	tetracysteine	92-105	doublesex and mab-3 related transcription factor 1	Homo sapiens	127-132
26542333-0	2015	Correction: DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.	Iron	17-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	12-16
28694024-5	2017	In addition, in the enterocytes, hepcidin inhibits the iron influx by acting on the apical transporter, DMT1.	Iron	55-59	doublesex and mab-3 related transcription factor 1	Homo sapiens	104-108
28904291-0	2017	Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells.	Cadmium	51-58	doublesex and mab-3 related transcription factor 1	Homo sapiens	33-37
28904291-1	2017	Intestinal absorption of cadmium (Cd) is considered to be mediated mainly by the ferrous iron transporter DMT1, or the calcium transporter CaT1.	Cadmium	25-32	doublesex and mab-3 related transcription factor 1	Homo sapiens	106-110
28904291-1	2017	Intestinal absorption of cadmium (Cd) is considered to be mediated mainly by the ferrous iron transporter DMT1, or the calcium transporter CaT1.	Cadmium	34-36	doublesex and mab-3 related transcription factor 1	Homo sapiens	106-110
28904291-5	2017	The transfection of DMT1 siRNA significantly decreased the Cd uptake from the apical side at 5 muM, but not at 0.1 or 1 muM.	Cadmium	59-61	doublesex and mab-3 related transcription factor 1	Homo sapiens	20-24
28904291-8	2017	These results suggest that DMT1 and ZIP14 play different roles in intestinal Cd absorption depending on the concentration of Cd.	Cadmium	77-79	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
28904291-8	2017	These results suggest that DMT1 and ZIP14 play different roles in intestinal Cd absorption depending on the concentration of Cd.	Cadmium	125-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
25491917-0	2015	Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane.	Iron	14-18	doublesex and mab-3 related transcription factor 1	Homo sapiens	82-86
26722561-0	2015	Biochemical changes correlated with blood thiamine and its phosphate esters levels in patients with diabetes type 1 (DMT1).	Thiamine	42-50	doublesex and mab-3 related transcription factor 1	Homo sapiens	117-121
26722561-0	2015	Biochemical changes correlated with blood thiamine and its phosphate esters levels in patients with diabetes type 1 (DMT1).	phosphate esters	59-75	doublesex and mab-3 related transcription factor 1	Homo sapiens	117-121
26722561-2	2015	However, little is known on the positive effects of thiamine in diabetic type 1 (DMT1) patients.	Thiamine	52-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	81-85
26722561-3	2015	The objectives of this study were to evaluate the biochemical changes related to thiamine deficiency in patients with DMT1 outcomes among Saudi adults.	Thiamine	81-89	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
26722561-4	2015	We hypothesized that blood thiamine deficiency in patients with DMT1 manifestations might lead to an increase in metabolic syndrome.	Thiamine	27-35	doublesex and mab-3 related transcription factor 1	Homo sapiens	64-68
26722561-12	2015	The results support a pivotal role of blood thiamine and its phosphate esters in preventing the biochemical changes and complications in patients with DMT1.	Thiamine	44-52	doublesex and mab-3 related transcription factor 1	Homo sapiens	151-155
26722561-12	2015	The results support a pivotal role of blood thiamine and its phosphate esters in preventing the biochemical changes and complications in patients with DMT1.	phosphate esters	61-77	doublesex and mab-3 related transcription factor 1	Homo sapiens	151-155
26360295-0	2015	DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.	Iron	5-9	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
26360295-6	2015	To sum up, the present work unveils the role of DMT1 in mediating the neuroregenerative action of iron.	Iron	98-102	doublesex and mab-3 related transcription factor 1	Homo sapiens	48-52
25491917-2	2015	DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports dietary iron into the cytosol.	Iron	21-25	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
25491917-2	2015	DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports dietary iron into the cytosol.	Iron	128-132	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-4
25491917-3	2015	TfR1 is not directly engaged in the intestinal absorption of free iron, and iron uptake by DMT1 is attenuated by ferristatin II treatment.	Iron	76-80	doublesex and mab-3 related transcription factor 1	Homo sapiens	91-95
25491917-3	2015	TfR1 is not directly engaged in the intestinal absorption of free iron, and iron uptake by DMT1 is attenuated by ferristatin II treatment.	ferristatin II	113-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	91-95
25422090-4	2015	Compared with inorganic iron groups, in which higher FeSO4 absorption than Fe2(SO4)3 was observed, supplementation with organic Fe glycine chelate significantly increased the Fe concentration in the duodenum and jejunum (P < 0.05), however, decreased DMT1 and DcytB messenger RNA (mRNA) levels (P < 0.05).	fe glycine	128-138	doublesex and mab-3 related transcription factor 1	Homo sapiens	254-258
24839540-1	2014	In this study the mu opioid receptor (MOR) ligands DALDA (Tyr-d-Arg-Phe-Lys-NH2) and Dmt1-DALDA (Dmt-d-Arg-Phe-Lys-NH2, Dmt = 2",6"-dimethyltyrosine) were glycosylated at the N- or C-terminus.	dmt	97-100	doublesex and mab-3 related transcription factor 1	Homo sapiens	85-89
26401661-4	2015	These 2 ovarian factors, together with retinoic acid (RA) action, promote feminization partially through the repression of the masculinizing activities of SOX9, FGF9 and DMRT1.	Tretinoin	39-52	doublesex and mab-3 related transcription factor 1	Homo sapiens	170-175
24731925-6	2014	We demonstrated that the calcium-containing ferritin composites can be absorbed by Caco-2 cells through a process where a TfR1 receptor is involved, whereas the uptake of free calcium ions has been known to be associated with another receptor, DMT1, indicating that the calcium ions encapsulated in supramolecular protein cages can be internalized by the Caco-2 cells through a different pathway from its free analogs for calcium supplementation.	Calcium	25-32	doublesex and mab-3 related transcription factor 1	Homo sapiens	244-248
24815816-0	2014	Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.	Copper	32-38	doublesex and mab-3 related transcription factor 1	Homo sapiens	69-73
24815816-7	2014	Nano CuO at a concentration of 62.5 muM inhibited the mRNA expression of DMT1, and the difference was significant compared with CuSO4 and micron CuO.	Copper Sulfate	128-133	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-77
24856513-0	2014	DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation.	Retinoids	39-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-5
24856513-5	2014	We find that DMRT1 blocks testicular retinoic acid (RA) signaling from activating genes normally involved in female sex determination and ovarian development and show that inappropriate activation of these genes can drive sexual transdifferentiation.	Tretinoin	37-50	doublesex and mab-3 related transcription factor 1	Homo sapiens	13-18
24856513-5	2014	We find that DMRT1 blocks testicular retinoic acid (RA) signaling from activating genes normally involved in female sex determination and ovarian development and show that inappropriate activation of these genes can drive sexual transdifferentiation.	Tretinoin	52-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	13-18
24914556-3	2014	(2014) now show that the transcriptional regulator DMRT1 actively prevents postnatal male-to-female sex reversal by blocking the activation of retinoid-signaling-dependent feminization genes.	Retinoids	143-151	doublesex and mab-3 related transcription factor 1	Homo sapiens	51-56
24839540-1	2014	In this study the mu opioid receptor (MOR) ligands DALDA (Tyr-d-Arg-Phe-Lys-NH2) and Dmt1-DALDA (Dmt-d-Arg-Phe-Lys-NH2, Dmt = 2",6"-dimethyltyrosine) were glycosylated at the N- or C-terminus.	2',6'-dimethyltyrosine	126-148	doublesex and mab-3 related transcription factor 1	Homo sapiens	85-89
24278403-7	2013	Our findings reveal the possibility of an endocytic pathway for acquisition of dietary Fe(III) by the small intestinal epithelium, which would complement the established DMT-1 pathway for soluble Fe(II).	ferric sulfate	87-94	doublesex and mab-3 related transcription factor 1	Homo sapiens	170-175
24475238-2	2014	The iron transport protein DMT1 is known to be increased in Parkinson"s brains linking functional transport mechanisms with iron accumulation.	Iron	4-8	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
24475238-2	2014	The iron transport protein DMT1 is known to be increased in Parkinson"s brains linking functional transport mechanisms with iron accumulation.	Iron	124-128	doublesex and mab-3 related transcription factor 1	Homo sapiens	27-31
24475238-3	2014	The regulation of DMT1 is therefore critical to the management of iron uptake in the disease setting.	Iron	66-70	doublesex and mab-3 related transcription factor 1	Homo sapiens	18-22
24475238-8	2014	We suggest that in Parkinson"s disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes.	Iron	50-54	doublesex and mab-3 related transcription factor 1	Homo sapiens	132-136
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	12-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	12-21	doublesex and mab-3 related transcription factor 1	Homo sapiens	183-187
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	141-150	doublesex and mab-3 related transcription factor 1	Homo sapiens	118-122
24517121-1	2014	BACKGROUND: Vitamin D deficiency is an increasingly recognized comorbidity in patients with type 1 diabetes mellitus (DMT1), suggesting that vitamin D deficiency might play a role in DMT1.	Vitamin D	141-150	doublesex and mab-3 related transcription factor 1	Homo sapiens	183-187
24517121-2	2014	We aimed to determine and compare the vitamin D status of Saudi adults with and without DMT1.	Vitamin D	38-47	doublesex and mab-3 related transcription factor 1	Homo sapiens	88-92
24517121-6	2014	RESULTS: Both the DMT1 and healthy groups had vitamin D deficiency.	Vitamin D	46-55	doublesex and mab-3 related transcription factor 1	Homo sapiens	18-22
24517121-9	2014	Overall, 100% of the DMT1 adults and 78% of the healthy children were vitamin D deficient.	Vitamin D	70-79	doublesex and mab-3 related transcription factor 1	Homo sapiens	21-25
24517121-10	2014	CONCLUSION: The prevalence of vitamin D deficiency among DMT1 adults was relatively high.	Vitamin D	30-39	doublesex and mab-3 related transcription factor 1	Homo sapiens	57-61
24278403-7	2013	Our findings reveal the possibility of an endocytic pathway for acquisition of dietary Fe(III) by the small intestinal epithelium, which would complement the established DMT-1 pathway for soluble Fe(II).	ammonium ferrous sulfate	196-202	doublesex and mab-3 related transcription factor 1	Homo sapiens	170-175
23633457-5	2013	In FH-deficient kidney cancer, levels of AMP-activated protein kinase (AMPK), a cellular energy sensor, are decreased resulting in diminished p53 levels, decreased expression of the iron importer, DMT1, leading to low cellular iron levels, and to enhanced fatty acid synthesis by diminishing phosphorylation of acetyl CoA carboxylase, a rate-limiting step for fatty acid synthesis.	Iron	182-186	doublesex and mab-3 related transcription factor 1	Homo sapiens	197-201
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Hematoporphyrins	46-48	doublesex and mab-3 related transcription factor 1	Homo sapiens	150-154
23065424-3	2012	We studied the modulatory role of inflammatory agents (IL6 and LPS) over Hpc and DMT1 mRNA expression in HepG2 cells preloaded with Fe.	Iron	132-134	doublesex and mab-3 related transcription factor 1	Homo sapiens	81-85
22884366-2	2012	In this study, we show that after Apc deletion, the cellular iron acquisition proteins TfR1 and DMT1 are rapidly induced.	Iron	61-65	doublesex and mab-3 related transcription factor 1	Homo sapiens	96-100
22281055-3	2012	Here, we demonstrated for the first time that HP could induce a significant increase in the expression of HIF-1alpha as well as iron uptake (TfR1 and DMT1) and release (Fpn1) proteins and thus increase transferrin-bound iron (Tf-Fe) and non-transferrin-bound iron (NTBI) uptake and iron release, and also a progressive increase in cellular iron content in the cultured neurons.	Iron	128-132	doublesex and mab-3 related transcription factor 1	Homo sapiens	150-154
21978284-0	2011	Superpotent [Dmt1] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed mu/delta opioid receptor agonistic properties.	4-aminotetrahydro-2-benzazepin-3-one	59-95	doublesex and mab-3 related transcription factor 1	Homo sapiens	13-17
19558223-5	2009	Increased expression of ferritin and elevated levels of RNA for DMT1, proteins for iron storage and transport respectively, followed MNP exposures, but values were significant for only those with co-exposures to inorganic acid and organic aerosols.	Iron	83-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	64-68
21346101-2	2011	Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	57-61
21346101-3	2011	Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess.	Iron	41-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	13-17
21346101-6	2011	Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds.	Iron	125-129	doublesex and mab-3 related transcription factor 1	Homo sapiens	138-142
21437029-2	2011	Iron acquisition occurs in the duodenum via divalent metal transporter (DMT1) and ferroportin.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	72-76
20951351-7	2010	DMRT1 acts in spermatogonia to restrict RA responsiveness, directly repress Stra8 transcription, and activate transcription of the spermatogonial differentiation factor Sohlh1, thereby preventing meiosis and promoting spermatogonial development.	Tretinoin	40-42	doublesex and mab-3 related transcription factor 1	Homo sapiens	0-5
20056824-9	2010	Transgenic overexpression of Dmrt1 in XX fish resulted in decreased aromatase gene expression, reduced serum estradiol-17beta levels, retardation of the ovarian cavity"s development, varying degrees of follicular degeneration, and even a partial to complete sex reversal.	17beta	119-125	doublesex and mab-3 related transcription factor 1	Homo sapiens	29-34
21447267-1	2010	INTRODUCTION: Leptin and soluble form of leptin receptor play a great role in both carbohydrate and fat metabolism which is very important in diabetes mellitus type (DMT1) patients.	Carbohydrates	83-95	doublesex and mab-3 related transcription factor 1	Homo sapiens	166-170
21079975-9	2011	RESULTS: Heme-Fe was bioavailable and induced an intracellular increase in iron, ferritin and HO1 levels and a decrease in DMT1 expression.	heme-fe	9-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	123-127
21346155-1	2011	Iron homeostasis-related genes (e.g., Dmt1 and Dcytb) are upregulated by hypoxia-inducible factor 2alpha (HIF2alpha) during iron deficiency in the mammalian intestine.	Iron	0-4	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-42
20807120-14	2010	CONCLUSIONS: We demonstrate that (1) CGM is a useful approach in DMT1 patients who undergo an exercise program and (2) IHE is associated with delayed nocturnal hypoglycemia.	cgm	37-40	doublesex and mab-3 related transcription factor 1	Homo sapiens	65-69
20597505-0	2010	Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes.	Calcium	21-28	doublesex and mab-3 related transcription factor 1	Homo sapiens	92-97
20597505-0	2010	Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes.	Iron	41-45	doublesex and mab-3 related transcription factor 1	Homo sapiens	92-97
20597505-5	2010	Calcium and iron treatments decreased DMT-1 protein in Caco-2 cell membranes, although total DMT-1 in whole cell lysates was unchanged by either iron or calcium.	Calcium	0-7	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-43
20597505-5	2010	Calcium and iron treatments decreased DMT-1 protein in Caco-2 cell membranes, although total DMT-1 in whole cell lysates was unchanged by either iron or calcium.	Iron	12-16	doublesex and mab-3 related transcription factor 1	Homo sapiens	38-43
20597505-7	2010	Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell.	Calcium	22-29	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-78
20597505-7	2010	Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell.	Iron	38-42	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-78
20597505-7	2010	Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell.	Iron	142-146	doublesex and mab-3 related transcription factor 1	Homo sapiens	73-78
19195878-3	2009	Six of these genes, i.e. TFPI2, GPX3, GPX1, IGFBP6, IRF7 and DMRT1, showed promoter hypermethylation in one or more gastric cancer cell lines, but were unmethylated in normal gastric mucosa by bisulphite sequencing and methylation-specific PCR analysis.	hydrogen sulfite	193-203	doublesex and mab-3 related transcription factor 1	Homo sapiens	61-66
18528644-10	2008	Heme oxygenase 1 expression increased and DMT1 expression decreased with higher heme Fe concentrations in the media.	Heme	80-84	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46
18528644-10	2008	Heme oxygenase 1 expression increased and DMT1 expression decreased with higher heme Fe concentrations in the media.	Iron	85-87	doublesex and mab-3 related transcription factor 1	Homo sapiens	42-46