PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32542680-7	2020	Genetic interaction analyses with CER1 (ECERIFERUM 1), CER3 (ECERIFERUM 3) and MAH1 (Mid-chain Alkane Hydroxylase 1) in wax biosynthesis and stomatal OCL formation showed that OSP1 may act upstream of CER3 in wax biosynthesis, and implicate that wax composition percentage changes and keeping ketones in a lower level play roles, at least partially, in forming stomatal ledges.	Ketones	293-300	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	55-59
32542680-7	2020	Genetic interaction analyses with CER1 (ECERIFERUM 1), CER3 (ECERIFERUM 3) and MAH1 (Mid-chain Alkane Hydroxylase 1) in wax biosynthesis and stomatal OCL formation showed that OSP1 may act upstream of CER3 in wax biosynthesis, and implicate that wax composition percentage changes and keeping ketones in a lower level play roles, at least partially, in forming stomatal ledges.	Ketones	293-300	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	61-73
32542680-7	2020	Genetic interaction analyses with CER1 (ECERIFERUM 1), CER3 (ECERIFERUM 3) and MAH1 (Mid-chain Alkane Hydroxylase 1) in wax biosynthesis and stomatal OCL formation showed that OSP1 may act upstream of CER3 in wax biosynthesis, and implicate that wax composition percentage changes and keeping ketones in a lower level play roles, at least partially, in forming stomatal ledges.	Ketones	293-300	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	201-205
30851618-5	2019	CER1 and CER3 proteins have high amino acid similarity and both are involved in alkane synthesis in Arabidopsis.	Alkanes	80-86	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	9-13
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Alkanes	253-260	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	165-176
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Alkanes	253-260	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	178-182
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Waxes	286-289	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	165-176
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Waxes	286-289	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	178-182
31941670-0	2020	CER16 inhibits post-transcriptional gene silencing of CER3 to regulate alkane biosynthesis.	Alkanes	71-77	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	54-58
31941670-6	2020	Comparative transcriptomic analysis revealed that transcripts of CER3, previously shown to play a principal role in alkane production, were markedly reduced in the cer16 mutants.	Alkanes	116-122	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	65-69
30851618-8	2019	CER1 and CER3 proteins are structurally similar, but CER1 proteins have more conserved histidine-containing motifs common to fatty acid hydroxylases and stearoyl-CoA desaturases.	Histidine	87-96	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	9-13
22773744-0	2012	Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex.	Alkanes	24-30	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	99-110
29506042-0	2018	GCN5 contributes to stem cuticular wax biosynthesis by histone acetylation of CER3 in Arabidopsis.	Waxes	35-38	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	78-82
29506042-6	2018	Notably, overexpression of CER3 in the gcn5-2 mutant rescued the defect in stem cuticular wax biosynthesis.	Waxes	90-93	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	27-31
28407124-7	2017	The abundances of both branched wax constituents and accompanying unbranched compounds were reduced on the cer6, cer3 and cer1 mutants but not cer4, indicating that branched compounds are in part synthesized by the same machinery as unbranched compounds.	Waxes	32-35	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	113-117
27354553-3	2016	Genome-wide basal and induced transcriptome changes regulated by SDG8 and/or SDG25 showed that two genes of the SDG-dependent transcriptome, CAROTENOID ISOMERASE2 (CCR2) and ECERIFERUM3 (CER3), were also required for plant immunity, establishing mechanisms in defense functions for SDG8 and SDG25.	secoisolariciresinol diglucoside	65-68	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	174-185
27354553-3	2016	Genome-wide basal and induced transcriptome changes regulated by SDG8 and/or SDG25 showed that two genes of the SDG-dependent transcriptome, CAROTENOID ISOMERASE2 (CCR2) and ECERIFERUM3 (CER3), were also required for plant immunity, establishing mechanisms in defense functions for SDG8 and SDG25.	secoisolariciresinol diglucoside	65-68	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	187-191
27354553-4	2016	CCR2 catalyzes the biosynthesis of carotenoids, whereas CER3 is involved in the biosynthesis of cuticular wax.	Waxes	106-109	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	56-60
27354553-6	2016	Loss of immunity in sdg mutants was attributed to altered global and CCR2- and CER3-specific histone lysine methylation (HLM).	secoisolariciresinol diglucoside	20-23	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	79-83
27354553-6	2016	Loss of immunity in sdg mutants was attributed to altered global and CCR2- and CER3-specific histone lysine methylation (HLM).	Lysine	101-107	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	79-83
30514726-6	2019	We previously showed that a complex made of Arabidopsis ECERIFERUM1 (CER1) and CER3 catalyzes the conversion of acyl-Coenzyme A"s to alkanes with strict substrate specificity for compounds containing more than 29 carbons.	Alkanes	133-140	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	79-83
30514726-6	2019	We previously showed that a complex made of Arabidopsis ECERIFERUM1 (CER1) and CER3 catalyzes the conversion of acyl-Coenzyme A"s to alkanes with strict substrate specificity for compounds containing more than 29 carbons.	Carbon	213-220	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	79-83
30514726-8	2019	In a yeast strain engineered to produce very-long-chain fatty acids, CER1-LIKE1 interacted with CER3 and cytochrome B5 to form a functional complex leading to the production of alkanes that are of different chain lengths compared to that produced by CER1-containing complexes.	chain fatty acids	50-67	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	96-100
30514726-8	2019	In a yeast strain engineered to produce very-long-chain fatty acids, CER1-LIKE1 interacted with CER3 and cytochrome B5 to form a functional complex leading to the production of alkanes that are of different chain lengths compared to that produced by CER1-containing complexes.	Alkanes	177-184	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	96-100
26023108-4	2015	The transcriptional expression of CsWAX2 was found to be induced by low temperature, drought, salt stress and ABA, while the ectopic expression of CsWAX2 in an Arabidopsis wax2 mutant could partially complement the glossy stem phenotype.	alisol B 23-acetate	110-113	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	172-176
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	37-40	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	118-122
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	126-129	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	118-122
22773744-0	2012	Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex.	Alkanes	152-158	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	99-110
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	249-260
19892830-6	2009	The CER1, CER4, WAX2 and SHN1 genes are known to be responsible for wax biosynthesis in Arabidopsis.	Waxes	68-71	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	16-20
14756310-9	2003	The FLP1 protein is likely to play a role in the synthesis of the components of tryphine, sporopollenin of exine and the wax of stems and siliques.	tryphine	80-88	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-8
14756310-9	2003	The FLP1 protein is likely to play a role in the synthesis of the components of tryphine, sporopollenin of exine and the wax of stems and siliques.	sporopollenin	90-103	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-8
8811860-1	1996	The eceriferum3 (cer3) locus encodes one of 21 gene products known to be involved in wax biosynthesis in Arabidopsis thaliana.	Waxes	85-88	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-15
8811860-1	1996	The eceriferum3 (cer3) locus encodes one of 21 gene products known to be involved in wax biosynthesis in Arabidopsis thaliana.	Waxes	85-88	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	17-21
12228482-10	1995	The CER3 gene product may be involved in release of fatty acids from elongase complexes.	Fatty Acids	52-63	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-8
17624331-2	2007	The Arabidopsis CER3 gene is important for cuticular wax biosynthesis and was reported to correspond to At5g02310 encoding an E3 ubiquitin ligase.	Waxes	53-56	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	16-20
17376164-4	2007	Esters with even numbers of carbons prevailed, with C(42), C(44) and C(46) favoured in the wild types, a predominance of C(42) in cer2 and cer6 mutants, and a relative shift towards C(46) in cer3 and cer23 mutants.	Esters	0-6	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	191-195
17376164-8	2007	In contrast, cer1, cer3, cer10, cer13 and cer22 showed ester alcohol patterns with increased levels of C(30), only partially following the shift in chain lengths of the free alcohols in stem wax.	ester alcohol	55-68	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	19-23
17376164-8	2007	In contrast, cer1, cer3, cer10, cer13 and cer22 showed ester alcohol patterns with increased levels of C(30), only partially following the shift in chain lengths of the free alcohols in stem wax.	Alcohols	174-182	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	19-23
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Waxes	10-13	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Aldehydes	113-122	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Alkanes	124-131	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Alcohols	143-151	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Ketones	157-164	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Alcohols	196-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Esters	210-216	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-8	2003	WAX2 has six transmembrane domains, a His-rich diiron binding region at the N-terminal region, and a large soluble C-terminal domain.	Histidine	38-41	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-4
12724542-8	2003	WAX2 has six transmembrane domains, a His-rich diiron binding region at the N-terminal region, and a large soluble C-terminal domain.	diiron	47-53	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-4
12724542-11	2003	Based on these analyses, we predict that WAX2 has a metabolic function associated with both cuticle membrane and wax synthesis.	Waxes	113-116	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	41-45
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	262-266
33945542-8	2021	Keeping this fact in mind a wax biosynthetic gene CER3, from Arabidopsis thaliana was transformed into G. hirsutum and the plants were evaluated for their resistance against whitefly and CLCuV transmission.	Waxes	28-31	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	50-54
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Aldehydes	77-86	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	n-alkanes	88-97	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	n-alcohols	109-119	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Ketones	125-132	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Water	184-189	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Alkanes	90-97	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-4	2021	cer3-6, a known Arabidopsis wax-deficient mutant (with distinct reduction in aldehydes, n-alkanes, secondary n-alcohols, and ketones compared to wild type (WT)), was most sensitive to water loss, while dewax, a known wax overproducer (greater alkanes and ketones compared to WT), was more resistant to dehydration compared to WT.	Ketones	255-262	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	0-6
33557073-6	2021	Gas Chromatography-Mass Spectroscopy (GC-MS) analysis identified a characteristic decrease in the accumulation of certain waxes (e.g., alkanes, alcohols) in Arabidopsis cuticles under cold acclimation, which was additionally reduced in cer3-6.	Waxes	122-127	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	236-242