PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33245899-0	2021	Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.	Fatty Acids	75-85	C1q and TNF related 6	Homo sapiens	12-17
34469206-7	2021	The results show that the expression of CTRP6 decreased in HCY-induced VSMCs.	Homocysteine	59-62	C1q and TNF related 6	Homo sapiens	40-45
34469206-8	2021	In addition, CTRP6 overexpression inhibited the proliferation and migration of HCY-induced VSMCs, as well as cell cycle acceleration and dedifferentiation.	Homocysteine	79-82	C1q and TNF related 6	Homo sapiens	13-18
34469206-9	2021	Overexpression of CTRP6 increased HCY-induced PPARgamma expression and inhibited NLRP3 expression.	Homocysteine	34-37	C1q and TNF related 6	Homo sapiens	18-23
34469206-10	2021	The addition of GW9662 and rosiglitazone further demonstrated that overexpression of CTRP6 inhibited HCY-induced VSMC proliferation, migration, and dedifferentiation through PPARgamma/NLRP3 signaling.	2-chloro-5-nitrobenzanilide	16-22	C1q and TNF related 6	Homo sapiens	85-90
34469206-10	2021	The addition of GW9662 and rosiglitazone further demonstrated that overexpression of CTRP6 inhibited HCY-induced VSMC proliferation, migration, and dedifferentiation through PPARgamma/NLRP3 signaling.	Rosiglitazone	27-40	C1q and TNF related 6	Homo sapiens	85-90
34469206-10	2021	The addition of GW9662 and rosiglitazone further demonstrated that overexpression of CTRP6 inhibited HCY-induced VSMC proliferation, migration, and dedifferentiation through PPARgamma/NLRP3 signaling.	Homocysteine	101-104	C1q and TNF related 6	Homo sapiens	85-90
34964705-0	2022	C1q/tumor necrosis factor related protein 6 (CTRP6) regulates the phenotypes of high glucose-induced gestational trophoblast cells via peroxisome proliferator-activated receptor gamma (PPARgamma) signaling.	Glucose	85-92	C1q and TNF related 6	Homo sapiens	0-43
34964705-0	2022	C1q/tumor necrosis factor related protein 6 (CTRP6) regulates the phenotypes of high glucose-induced gestational trophoblast cells via peroxisome proliferator-activated receptor gamma (PPARgamma) signaling.	Glucose	85-92	C1q and TNF related 6	Homo sapiens	45-50
34964705-6	2022	The results of the present study revealed that CTRP6 and PPARgamma were both upregulated in high glucose-induced cells.	Glucose	97-104	C1q and TNF related 6	Homo sapiens	47-52
34964705-9	2022	In conclusion, CTRP6 regulated the viability, migration and invasion of high glucose-induced gestational trophoblast cells through PPARgamma signaling.	Glucose	77-84	C1q and TNF related 6	Homo sapiens	15-20
33959757-8	2021	Furthermore, C1QTNF6 overexpression upregulated the levels of TNFalpha, IL6, and CRP and activated the AKT/NF-kappaB pathway in LPS-treated KGN cells, whereas C1QTNF6 knockdown and BAY-117082 (an NF-kappaB inhibitor) treatment resulted in the opposite effects.	3-(4-methylphenylsulfonyl)-2-propenenitrile	181-191	C1q and TNF related 6	Homo sapiens	13-20
33245899-8	2021	Decreased CTRP6 and p-AMPK were detected in UUO-induced kidney fibrosis and in TGF-beta1-treated HK-2 cells.	uuo	44-47	C1q and TNF related 6	Homo sapiens	10-15
32170998-3	2020	C1q/tumor necrosis factor-alpha-related protein-6 (CTRP6) is a novel adipokine involved in glucose and lipid metabolism, host inflammation, and organogenesis.	Glucose	91-98	C1q and TNF related 6	Homo sapiens	51-56
32077518-0	2020	Knockdown of CTRP6 inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells through regulating the Akt/NF-kappaB pathway.	Glucose	33-40	C1q and TNF related 6	Homo sapiens	13-18
32077518-5	2020	The following lose-/gain-of-function assays demonstrated that CTRP6 knockdown significantly inhibited HG-induced reactive oxygen species (ROS) production in MCs.	Oxygen	122-128	C1q and TNF related 6	Homo sapiens	62-67
32077518-9	2020	Treatment with LY294002, an inhibitor of Akt, reversed the induction effects of CTRP6 overexpression on ROS production, inflammation and ECM accumulation in MCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	C1q and TNF related 6	Homo sapiens	80-85
33269376-7	2021	Results: In this study, we found that C1QTNF6 significantly promoted the proliferation of SPCA1 and A549 cells by MTT and colony formation assays.	monooxyethylene trimethylolpropane tristearate	114-117	C1q and TNF related 6	Homo sapiens	38-45
31412378-7	2021	Correlation analysis revealed that there was a positive relationship between circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c, but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis revealed that high serum CTRP6 levels are markedly associated with OW/OB.	Technetium	131-133	C1q and TNF related 6	Homo sapiens	89-94
32041782-5	2020	We found that CTRP6 bound to AcBSA and to a lesser extent to zymosan.	acbsa	29-34	C1q and TNF related 6	Homo sapiens	14-19
32041782-8	2020	We identified l-fucose as a ligand for CTRP6 and that it bound to certain enteroaggregative Escherichia coli and Pseudomonas aeruginosa isolates, whereas to other bacterial isolates, no binding was observed.	Fucose	14-22	C1q and TNF related 6	Homo sapiens	39-44
31292940-7	2019	Based on the TCGA database and Oncomine dataset, we found that C1QTNF6 was over expressed in lung adenocarcinoma.	oncomine	31-39	C1q and TNF related 6	Homo sapiens	63-70
30665074-5	2019	The results indicated that the signaling peptide of CTRP6 was located at among positions 21 and 22, and the phosphorylation sites were at 15 (Ser), 4 (Thr) and 4 (Tyr), respectively.	Serine	142-145	C1q and TNF related 6	Homo sapiens	52-57
30665074-5	2019	The results indicated that the signaling peptide of CTRP6 was located at among positions 21 and 22, and the phosphorylation sites were at 15 (Ser), 4 (Thr) and 4 (Tyr), respectively.	Threonine	151-154	C1q and TNF related 6	Homo sapiens	52-57
30665074-5	2019	The results indicated that the signaling peptide of CTRP6 was located at among positions 21 and 22, and the phosphorylation sites were at 15 (Ser), 4 (Thr) and 4 (Tyr), respectively.	Tyrosine	163-166	C1q and TNF related 6	Homo sapiens	52-57
27125977-5	2016	Interestingly, the effect of CTRP6 siRNA was attenuated by U0126 (a special p-Erk1/2 inhibitor) in myoblasts.	U 0126	59-64	C1q and TNF related 6	Homo sapiens	29-34
30083983-1	2018	AIMS: C1q/tumor necrosis factor-related protein-6 (CTRP6) is a novel adipokine and has emerged as an important mediator for lipid and glucose metabolism.	Glucose	134-141	C1q and TNF related 6	Homo sapiens	6-49
30083983-1	2018	AIMS: C1q/tumor necrosis factor-related protein-6 (CTRP6) is a novel adipokine and has emerged as an important mediator for lipid and glucose metabolism.	Glucose	134-141	C1q and TNF related 6	Homo sapiens	51-56
30083983-5	2018	OGTT were performed in 48 healthy individuals to investigate the association of CTRP6 with glucose, insulin and other adipokines.	Glucose	91-98	C1q and TNF related 6	Homo sapiens	80-85
30083983-8	2018	Serum CTRP6 levels were found to be related positively to BMI, WHR, FAT%, TC, TG, HbA1c, FBG, 2 h-OGTT, fasting insulin (FIns), 2 h-Ins, HOMA-IR and TNF-alpha, and negatively with HDL-C and Adipoq in all individuals (P < 0.05 or P < 0.01).	Technetium	74-76	C1q and TNF related 6	Homo sapiens	6-11
30083983-10	2018	After an oral glucose challenge, serum CTRP6 concentrations exhibited a similar change with blood glucose, insulin, TNF-alpha and Adipoq.	Glucose	14-21	C1q and TNF related 6	Homo sapiens	39-44
30083983-10	2018	After an oral glucose challenge, serum CTRP6 concentrations exhibited a similar change with blood glucose, insulin, TNF-alpha and Adipoq.	Glucose	98-105	C1q and TNF related 6	Homo sapiens	39-44
28726640-6	2017	Overexpressing mouse or human CTRP6 impaired glucose disposal in peripheral tissues in response to glucose and insulin challenge in wild-type mice.	Glucose	45-52	C1q and TNF related 6	Homo sapiens	30-35
20102710-4	2010	In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes.	Fatty Acids	118-128	C1q and TNF related 6	Homo sapiens	41-46
20102710-5	2010	Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.	Fatty Acids	28-38	C1q and TNF related 6	Homo sapiens	6-11