PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28843399-7	2017	CB-5083 induced ER stress, as documented through: 1) prominent expression of chaperones (GRP78, GRP94, PDI, DNAJC3, and DNAJB9); 2) increased activation of IRE1-alpha, as demonstrated by the splicing of XBP1; and 3) activation of PERK, which resulted in a significant overexpression of CHOP, and its downstream genes.	CB-5083	0-7	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	120-126
29198525-6	2017	ERdj4 associates with IRE1LD and recruits BiP through the stimulation of ATP hydrolysis, forcibly disrupting IRE1 dimers.	Adenosine Triphosphate	73-76	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
20591477-8	2010	SEM and EDXS show that MDG1 gels are capable of directing the formation of hydroxapatite.	hydroxapatite	75-88	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	23-27
28100868-8	2017	In contrast, retinol treatment significantly increased the mRNA expression of endoplasmic reticulum (ER) stress factors (heme oxygenase 1 (HMOX1), CCAAT/enhancer-binding protein homologous protein (CHOP), 78 kDa glucose-regulated protein (GRP78), and DnaJ (Hsp40) homolog, subfamily B, member 9 (DNAJB9)).	Vitamin A	13-20	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	251-294
28100868-8	2017	In contrast, retinol treatment significantly increased the mRNA expression of endoplasmic reticulum (ER) stress factors (heme oxygenase 1 (HMOX1), CCAAT/enhancer-binding protein homologous protein (CHOP), 78 kDa glucose-regulated protein (GRP78), and DnaJ (Hsp40) homolog, subfamily B, member 9 (DNAJB9)).	Vitamin A	13-20	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	296-302
28713956-0	2017	MDG-1 inhibits H2O2-induced apoptosis and inflammation in human umbilical vein endothelial cells.	Hydrogen Peroxide	15-19	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
28713956-1	2017	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has been reported to serve a role in antimyocardial ischemia by protecting cardiomyocytes from hypoxia/reoxygenation-induced damage.	Water	9-14	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
28713956-1	2017	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has been reported to serve a role in antimyocardial ischemia by protecting cardiomyocytes from hypoxia/reoxygenation-induced damage.	Polysaccharides	23-37	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
28713956-5	2017	Pretreatment with MDG-1 markedly reduced H2O2-induced cell death, ROS generation and inflammatory factor secretion.	Hydrogen Peroxide	41-45	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
28713956-5	2017	Pretreatment with MDG-1 markedly reduced H2O2-induced cell death, ROS generation and inflammatory factor secretion.	ros	66-69	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
28713956-6	2017	In addition, pretreatment with MDG-1 decreased the expression levels of proapoptotic proteins BCL2 associated X (Bax) and caspase-3, while it increased the expression levels of the antiapoptotic protein BCL2 apoptosis regulator (Bcl-2), compared with H2O2 treatment alone.	Hydrogen Peroxide	251-255	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	31-36
28713956-7	2017	Taken together, the present data suggest that MDG-1 protected HUVECs against H2O2-induced apoptosis and inflammation through inhibition of Bax/Bcl-2 protein ratio, caspase-3 expression, and inflammatory factor secretion.	Hydrogen Peroxide	77-81	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	46-51
28500249-7	2017	The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels.	4-phenylbutyric acid	22-39	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	323-328
28500249-7	2017	The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels.	4-phenylbutyric acid	41-44	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	323-328
22197795-0	2012	A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.	Polysaccharides	2-17	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
22197795-2	2012	Recent studies have confirmed the anti-ischemic properties of a water-soluble beta-D-fructan (MDG-1) from O. japonicus.	Water	64-69	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	94-99
22197795-2	2012	Recent studies have confirmed the anti-ischemic properties of a water-soluble beta-D-fructan (MDG-1) from O. japonicus.	levan	78-92	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	94-99
21307594-3	2011	Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58(IPK).	quinotrierixin	32-46	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	159-164
18708056-5	2008	Overexpressing BAP or ERdj4 inhibits preS posttranslocation as does the reduction of ATP levels.	Adenosine Triphosphate	85-88	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	22-27
20008963-0	2010	A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.	Polysaccharides	2-16	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
20008963-3	2010	Herein, we investigate the anti-ischemic properties of a water-soluble beta-d-fructan (MDG-1) from Ophiopogon japonicus, and assess the cytoprotective and proangiogenic effects of MDG-1.	Water	57-62	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	87-92
20008963-3	2010	Herein, we investigate the anti-ischemic properties of a water-soluble beta-d-fructan (MDG-1) from Ophiopogon japonicus, and assess the cytoprotective and proangiogenic effects of MDG-1.	Water	57-62	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	180-185
20008963-8	2010	Further study revealed that both MDG-1 and S1P induce Akt and ERK phosphorylation in a dose- and time-dependent manner, an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059, and MDG-1 can also induce eNOS phosphorylation and increases in production of NO.	Wortmannin	196-206	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	33-38
20008963-8	2010	Further study revealed that both MDG-1 and S1P induce Akt and ERK phosphorylation in a dose- and time-dependent manner, an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059, and MDG-1 can also induce eNOS phosphorylation and increases in production of NO.	Wortmannin	196-206	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	241-246
20008963-8	2010	Further study revealed that both MDG-1 and S1P induce Akt and ERK phosphorylation in a dose- and time-dependent manner, an effect that is attenuated by pre-treatment with either the Akt inhibitor wortmannin or the ERK inhibitor PD98059, and MDG-1 can also induce eNOS phosphorylation and increases in production of NO.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	228-235	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	33-38
12356756-6	2002	BAP stimulated the ATPase activity of BiP when added alone or together with the ER DnaJ protein, ERdj4, by promoting the release of ADP from BiP.	Adenosine Diphosphate	132-135	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	97-102
16205636-4	2006	Celecoxib, an NSAID, upregulated ER chaperones (GRP78 and its cochaperones ERdj3 and ERdj4) but also C/EBP homologous transcription factor (CHOP), a transcription factor involved in apoptosis.	Celecoxib	0-9	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	85-90
14516790-4	2003	Mdg1/ERdj4 mRNA is induced by activated macrophages, by nitric oxide (NO) and heat shock, and during terminal cell differentiation, whereas shear stress does not affect Mdg1/ERdj4 expression levels.	Nitric Oxide	56-68	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-4
14516790-4	2003	Mdg1/ERdj4 mRNA is induced by activated macrophages, by nitric oxide (NO) and heat shock, and during terminal cell differentiation, whereas shear stress does not affect Mdg1/ERdj4 expression levels.	Nitric Oxide	56-68	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	5-10
33656648-0	2021	Complete remission of DnaJ homolog subfamily B member 9-positive fibrillary glomerulonephritis following steroid monotherapy in an elderly Japanese woman.	Steroids	105-112	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	22-55