PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33503835-9	2021	As Kp-8 raised LH concentration, it could activate Kiss1r and stimulate the reproductive axis.	Luteinizing Hormone	15-17	KISS1 receptor	Rattus norvegicus	51-57
22982503-5	2012	At 34 days old, hypothalamic Kiss1r mRNA levels were significantly lower with CD than with CS.	Cadmium	78-80	KISS1 receptor	Rattus norvegicus	29-35
22982503-5	2012	At 34 days old, hypothalamic Kiss1r mRNA levels were significantly lower with CD than with CS.	Cesium	91-93	KISS1 receptor	Rattus norvegicus	29-35
31805798-7	2019	In addition, chronic exposure to sevoflurane down-regulated transcription of gonadotropin-releasing hormone (GnRH) and kisspeptin (Kiss)-1 as well as its receptor GPR54 in hypothalamus, attenuated GnRH receptor and LH-beta mRNA levels, but increased FSH-beta mRNA in pituitary gland, and enhanced mRNA of LH receptor and FSH receptor, but decreased INH-alpha and INH-betaA mRNA levels in testes.Discussion and conclusions: Sevoflurane induces disorders of spermatogenesis and causes testicular injury.	sevoflurane	33-44	KISS1 receptor	Rattus norvegicus	163-168
32921318-8	2020	The expression of kisspeptin and NKB in arcuate nucleus and their receptors kiss1r and NK3r in GnRH positive neurons of median eminence were markedly decreased in troxerutin-treated rats.	troxerutin	163-173	KISS1 receptor	Rattus norvegicus	76-82
33133462-8	2020	Furthermore, data from real-time quantitative PCR showed that injection of NPY significantly increased the gene expression of KiSS1 and GPR54, while treatment with BIBP3226 controlled the stimulative effects of NPY on gene expression of KiSS1 and GPR54.	BIBP 3226	164-172	KISS1 receptor	Rattus norvegicus	247-252
33280922-9	2021	Specifically, Cd exposure caused irregular estrous cyclicity, abnormal hypothalamic gene expression (upregulated - Kiss1, AR and mTOR; downregulated - Kiss1R, LepR and TNF-alpha), high LH levels, low AMH levels and abnormal ovarian follicular development, coupled with a reduction in ovarian reserve and antral follicle number was observed, suggesting ovarian depletion.	Cadmium	14-16	KISS1 receptor	Rattus norvegicus	151-157
32914264-0	2020	Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain.	Citalopram	0-12	KISS1 receptor	Rattus norvegicus	64-70
32914264-9	2020	This is the first report of the effects of escitalopram on POMC, kisspeptin, Kiss1R and MCHR1 in animal brain.	Citalopram	43-55	KISS1 receptor	Rattus norvegicus	77-83
31672553-0	2020	Early intervention with breast milk mesenchymal stem cells attenuates the development of diabetic-induced testicular dysfunction via hypothalamic Kisspeptin/Kiss1r-GnRH/GnIH system in male rats.	5-oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2	164-168	KISS1 receptor	Rattus norvegicus	157-163
31672553-0	2020	Early intervention with breast milk mesenchymal stem cells attenuates the development of diabetic-induced testicular dysfunction via hypothalamic Kisspeptin/Kiss1r-GnRH/GnIH system in male rats.	RFamide-related peptide-3, rat	169-173	KISS1 receptor	Rattus norvegicus	157-163
30668693-2	2019	We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin.	Dopamine	88-96	KISS1 receptor	Rattus norvegicus	52-66
30668693-2	2019	We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin.	Dopamine	88-96	KISS1 receptor	Rattus norvegicus	68-74
30668693-5	2019	In ovariectomized, estradiol-treated rats, the Kiss1r antagonist kisspeptin-234 abolished the Kp-10-induced increase in prolactin release but failed to prevent the concomitant reduction in the activity of tuberoinfundibular dopaminergic (TIDA) neurons, as determined by the 3,4-dihydroxyphenylacetic acid/dopamine ratio in the median eminence.	Kisspeptin 234	65-79	KISS1 receptor	Rattus norvegicus	47-53
30598349-4	2019	Benzoyl-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (16) exhibited high agonist activity for KISS1R and excellent metabolic stability in rat serum.	benzoyl-phe-azagly-leu-arg(me)-trp-nh2	0-38	KISS1 receptor	Rattus norvegicus	80-86
27981646-8	2017	Additionally, a few Kiss1r-expressing neurones in the dorsal ARN are tuberoinfundibular dopamine (TIDA) neurones, which control milk production by inhibiting prolactin secretion from the anterior pituitary.	Dopamine	88-96	KISS1 receptor	Rattus norvegicus	20-26
30255291-8	2019	Endogenous Kiss1r mRNA expression in GH3 cells was significantly increased by treatment with estradiol (E2) but not by TRH.	Estradiol	93-102	KISS1 receptor	Rattus norvegicus	11-17
29935068-3	2018	In the present study, the role of kisspeptin/ GPR54 signaling system was investigated on relaying the inhibitory influences of morphine on LH hormone secretion.	Morphine	127-135	KISS1 receptor	Rattus norvegicus	46-51
27981646-8	2017	Additionally, a few Kiss1r-expressing neurones in the dorsal ARN are tuberoinfundibular dopamine (TIDA) neurones, which control milk production by inhibiting prolactin secretion from the anterior pituitary.	tida	98-102	KISS1 receptor	Rattus norvegicus	20-26
27981646-9	2017	TIDA neurones showed a relatively weak Kiss1r ISH signal compared to POMC neurones, as well as low co-expression of Kiss1r (approximately 15%).	tida	0-4	KISS1 receptor	Rattus norvegicus	39-45
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	ac-d-tyr-hydroxyproline (hyp)-asn-thr-phe-azagly-leu-arg	88-144	KISS1 receptor	Rattus norvegicus	55-69
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	ac-d-tyr-hydroxyproline (hyp)-asn-thr-phe-azagly-leu-arg	88-144	KISS1 receptor	Rattus norvegicus	71-77
27519634-0	2016	Prepubertal exposure to an oestrogenic mycotoxin zearalenone induces central precocious puberty in immature female rats through the mechanism of premature activation of hypothalamic kisspeptin-GPR54 signaling.	Zearalenone	49-60	KISS1 receptor	Rattus norvegicus	193-198
23668015-10	2013	CONCLUSION: Dabuyin Wan may inhibit GnRH synthesis and release as well as startup of hypothalamic-pituitary-gonadal axis by down-regulating Kiss-1/GPR54 mRNA expression in hypothalamus, in order to realize the therapeutic effect on true precocious puberty.	dabuyin	12-19	KISS1 receptor	Rattus norvegicus	147-152
24617524-1	2014	This study investigated potential mechanisms by which age and IGF-I receptor (IGF-Ir) signaling in the neuroendocrine hypothalamus affect estradiol-positive feedback effects on GnRH neuronal activation and on kisspeptin and N-methyl-D-aspartate (NMDA)-induced LH release and on the abundance of NMDA receptor subunits Nr1 and Nr2b and Kiss1r transcript and protein in the hypothalamus of young and middle-aged female rats.	Estradiol	138-147	KISS1 receptor	Rattus norvegicus	335-341
24617524-4	2014	Estradiol priming significantly increased Kiss1r, Nr1, and Nr2b receptor transcript and protein abundance in young but not middle-aged female hypothalamus.	Estradiol	0-9	KISS1 receptor	Rattus norvegicus	42-48
25512707-6	2013	We used bisulfite-PCR-pyrosequencing to define the methylation in the promoters of Kiss1 and Kiss1r before and after puberty in female rats.	hydrogen sulfite	8-17	KISS1 receptor	Rattus norvegicus	93-99
23684378-9	2013	Kiss1r expression was increased in both placental zones at day 16 and 22 in response to dexamethasone-treatment.	Dexamethasone	88-101	KISS1 receptor	Rattus norvegicus	0-6
23684378-11	2013	Furthermore, the effects of dexamethasone on placental Kiss1/Kiss1r suggest glucocorticoid-induced placental growth retardation could be mediated, in part, via early stimulation of Kiss1 and the subsequent inhibition of trophoblast proliferation and invasion.	Dexamethasone	28-41	KISS1 receptor	Rattus norvegicus	61-67
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	tryptophanamide	149-156	KISS1 receptor	Rattus norvegicus	55-69
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	tryptophanamide	149-156	KISS1 receptor	Rattus norvegicus	71-77
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Testosterone	187-199	KISS1 receptor	Rattus norvegicus	55-69
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Testosterone	187-199	KISS1 receptor	Rattus norvegicus	71-77
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Water	235-240	KISS1 receptor	Rattus norvegicus	55-69
27589480-0	2016	Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.	Water	235-240	KISS1 receptor	Rattus norvegicus	71-77
26356830-6	2015	Furthermore, the mRNA expressions of androgen receptor (AR), kisspeptin encoded gene (Kiss-1) and its receptor (GPR54) in hypothalamus were significantly diminished by isoflurane (p<0.01).	Isoflurane	168-178	KISS1 receptor	Rattus norvegicus	112-117
26356830-7	2015	The results indicated that chronic exposure to isoflurane diminished the synthesis and secretion of GnRH by inhibiting the androgen-AR-Kisspeptin-GPR54 pathway and breaking the hypothalamic-pituitary-gonadal equilibrium, and therefore it could inhibit spermatogenesis.	Isoflurane	47-57	KISS1 receptor	Rattus norvegicus	146-151
25615539-0	2015	Prior attenuation of KiSS1/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats.	Ethinyl Estradiol	156-180	KISS1 receptor	Rattus norvegicus	27-32
24918545-0	2014	Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.	Testosterone	104-116	KISS1 receptor	Rattus norvegicus	61-75
24918545-8	2014	These results suggested that a controlled release of short-length KISS1 receptor agonists can suppress the hypothalamic-pituitary-gonadal axis and reduce testosterone levels.	Testosterone	154-166	KISS1 receptor	Rattus norvegicus	66-80
24857775-4	2014	The tetramethylrhodamine (TMR) and rhodamine green (RG)-labeled kisspeptins exhibited good binding and agonistic activities towards GPR54, and the results of the application studies demonstrated that these fluorescent probes could be used effectively for the detection of GPR54 receptors in flow cytometry and confocal microscopy experiments.	tetramethylrhodamine	4-24	KISS1 receptor	Rattus norvegicus	132-137
24857775-4	2014	The tetramethylrhodamine (TMR) and rhodamine green (RG)-labeled kisspeptins exhibited good binding and agonistic activities towards GPR54, and the results of the application studies demonstrated that these fluorescent probes could be used effectively for the detection of GPR54 receptors in flow cytometry and confocal microscopy experiments.	tetramethylrhodamine	4-24	KISS1 receptor	Rattus norvegicus	272-277
24857775-4	2014	The tetramethylrhodamine (TMR) and rhodamine green (RG)-labeled kisspeptins exhibited good binding and agonistic activities towards GPR54, and the results of the application studies demonstrated that these fluorescent probes could be used effectively for the detection of GPR54 receptors in flow cytometry and confocal microscopy experiments.	tetramethylrhodamine	26-29	KISS1 receptor	Rattus norvegicus	132-137
24857775-4	2014	The tetramethylrhodamine (TMR) and rhodamine green (RG)-labeled kisspeptins exhibited good binding and agonistic activities towards GPR54, and the results of the application studies demonstrated that these fluorescent probes could be used effectively for the detection of GPR54 receptors in flow cytometry and confocal microscopy experiments.	rhodamine green	35-50	KISS1 receptor	Rattus norvegicus	132-137
24056307-0	2013	Short-term neonatal/prepubertal exposure of dibutyl phthalate (DBP) advanced pubertal timing and affected hypothalamic kisspeptin/GPR54 expression differently in female rats.	Dibutyl Phthalate	44-61	KISS1 receptor	Rattus norvegicus	130-135
24056307-0	2013	Short-term neonatal/prepubertal exposure of dibutyl phthalate (DBP) advanced pubertal timing and affected hypothalamic kisspeptin/GPR54 expression differently in female rats.	Dibutyl Phthalate	63-66	KISS1 receptor	Rattus norvegicus	130-135
24047141-0	2013	Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.	Testosterone	103-115	KISS1 receptor	Rattus norvegicus	82-88
21074602-6	2011	The aim of this study was to evaluate whether the hypothalamic Kiss1-Kiss1r-GnRH system is also altered in dexamethasone-induced IUGR rats.	Dexamethasone	107-120	KISS1 receptor	Rattus norvegicus	69-75
23028524-12	2012	These data demonstrate that the stimulatory effect of NKB on LH secretion in intact female rats is dependent upon kisspeptin/GPR54 signaling, but not on Dyn signaling.	Luteinizing Hormone	61-63	KISS1 receptor	Rattus norvegicus	125-130
20580563-0	2010	2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.	2-acylamino-4,6-diphenylpyridine	0-32	KISS1 receptor	Rattus norvegicus	54-59
20580563-0	2010	2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.	Luteinizing Hormone	129-131	KISS1 receptor	Rattus norvegicus	54-59
20580563-4	2010	We recently reported 2-acylamino-4,6-diphenylpyridines as the first small molecule GPR54 antagonists with high potency.	2-acylamino-4,6-diphenylpyridines	21-54	KISS1 receptor	Rattus norvegicus	83-88
20580563-8	2010	In addition, intravenous administration of 15a to castrated male rat suppressed plasma LH level, which indicates the possibility of a small molecule GPR54 antagonist as a novel drug for sex-hormone dependent diseases.	15a	43-46	KISS1 receptor	Rattus norvegicus	149-154
20580563-8	2010	In addition, intravenous administration of 15a to castrated male rat suppressed plasma LH level, which indicates the possibility of a small molecule GPR54 antagonist as a novel drug for sex-hormone dependent diseases.	Luteinizing Hormone	87-89	KISS1 receptor	Rattus norvegicus	149-154
19094090-10	2009	Both acute and chronic stress levels of corticosterone resulted in a concomitant decrease in Kiss1 and an increase in kiss1r mRNA expression in the mPOA and ARC.	Corticosterone	40-54	KISS1 receptor	Rattus norvegicus	118-124
19141682-7	2009	Administration of indomethacin to cyclic female rats disturbed ovulation and resulted in a dramatic drop in ovarian KiSS-1, but not GPR54, cyclooxygenase-2 (COX-2), or progesterone receptor, mRNA levels at the time of ovulation; an effect mimicked by the selective COX-2 inhibitor NS398 and rescued by coadministration of PGE(2).	Indomethacin	18-30	KISS1 receptor	Rattus norvegicus	132-137
18208554-0	2008	KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone.	Estradiol	100-110	KISS1 receptor	Rattus norvegicus	11-16
18765263-4	2009	The effect was suppressed by the G-protein inhibitor GDP-beta-S and the calcium chelator BAPTA, and analysis of miniature EPSCs revealed an increase in mean amplitude but not event frequency, indicating that GPR54 and the mechanisms for enhancing EPSCs are postsynaptic, possibly involving changes in AMPA receptor number or conductance.	guanosine 5'-O-(2-thiodiphosphate)	53-63	KISS1 receptor	Rattus norvegicus	208-213
18765263-4	2009	The effect was suppressed by the G-protein inhibitor GDP-beta-S and the calcium chelator BAPTA, and analysis of miniature EPSCs revealed an increase in mean amplitude but not event frequency, indicating that GPR54 and the mechanisms for enhancing EPSCs are postsynaptic, possibly involving changes in AMPA receptor number or conductance.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	89-94	KISS1 receptor	Rattus norvegicus	208-213
18208554-5	2008	Using the real-time reverse transcription-polymerase chain reaction (RT-PCR), we found that the expression of KiSS-1 and GPR54 is differentially regulated by steroids.	Steroids	158-166	KISS1 receptor	Rattus norvegicus	121-126
15242985-6	2004	Hypothalamic expression of KiSS-1 and GPR54 genes changed throughout the estrous cycle and was significantly increased after gonadectomy, a rise that was prevented by sex steroid replacement both in males and females.	Steroids	171-178	KISS1 receptor	Rattus norvegicus	38-43