PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31460762-0	2019	A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells.	Sulfonamides	2-13	sialic acid binding Ig-like lectin F	Mus musculus	47-62
35452678-11	2022	Mice express the same structure, a sialylated keratan sulfate RPTPzeta isoform, that binds mouse Siglec-F and cross-reacts with human CD33 and Siglec-8.	Keratan Sulfate	46-61	sialic acid binding Ig-like lectin F	Mus musculus	97-105
35533451-9	2022	The proportions of eosinophils, neutrophils, Siglec-F+ neutrophils, lymphocytes, and T cell subsets were reduced by G-1, and this effect was attenuated by BPA.	bisphenol A	155-158	sialic acid binding Ig-like lectin F	Mus musculus	45-53
33289969-6	2020	Siglec-F overexpression activates an endocytic and pyroptotic inflammatory response in BV-2 cells, dependent on its sialic acid substrates and immunoreceptor tyrosine-based inhibition motif (ITIM) phosphorylation sites.	N-Acetylneuraminic Acid	116-127	sialic acid binding Ig-like lectin F	Mus musculus	0-8
33289969-6	2020	Siglec-F overexpression activates an endocytic and pyroptotic inflammatory response in BV-2 cells, dependent on its sialic acid substrates and immunoreceptor tyrosine-based inhibition motif (ITIM) phosphorylation sites.	Tyrosine	158-166	sialic acid binding Ig-like lectin F	Mus musculus	0-8
33319168-3	2020	Three days post-bleomycin, the inflammatory profile was typified by acute innate inflammation, pronounced neutrophilia, especially of SiglecF+ neutrophils, and alveolar macrophage loss.	Bleomycin	16-25	sialic acid binding Ig-like lectin F	Mus musculus	134-141
32247614-5	2020	In the nasal mucosa of both PBS- and OVA-challenged mice, we found a cell subset expressing the eosinophil marker Siglec-F in the Ly-6G+ neutrophil population.	Lead	28-31	sialic acid binding Ig-like lectin F	Mus musculus	114-122
31520477-6	2019	GM-CSF also enhanced Siglec-F expression in thioglycollate-induced peritoneal macrophages.	Thioglycolates	44-58	sialic acid binding Ig-like lectin F	Mus musculus	21-29
31460762-0	2019	A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells.	sialoside	14-23	sialic acid binding Ig-like lectin F	Mus musculus	47-62
31460762-5	2019	Here, we report the development of a ligand of Siglec-8 and its closest murine functional orthologue Siglec-F that is capable of targeting liposomes to cells expressing Siglec-8 or -F. A glycan microarray library of synthetic 9-N-sulfonyl sialoside analogues was screened to identify potential lead compounds.	9-n-sulfonyl sialoside	226-248	sialic acid binding Ig-like lectin F	Mus musculus	101-109
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	139-145	sialic acid binding Ig-like lectin F	Mus musculus	88-96
29645346-8	2018	Lastly, we show that the role of Siglec-F may be, at least in part, to regulate GMP viability.	guanosine 5'-monophosphorothioate	80-83	sialic acid binding Ig-like lectin F	Mus musculus	33-41
29659839-1	2018	Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6"-sulfated sialyl Lewis X and 6"-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays.	N-acetyllactosamine	124-144	sialic acid binding Ig-like lectin F	Mus musculus	0-8
29659839-1	2018	Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6"-sulfated sialyl Lewis X and 6"-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays.	N-acetyllactosamine	175-195	sialic acid binding Ig-like lectin F	Mus musculus	0-8
29253503-1	2018	Flow cytometry protocols designed to identify mouse eosinophils typically target Siglec F, an alpha-2,3-sialic acid binding transmembrane protein expressed universally on cells of this lineage.	alpha-2,3-sialic acid	94-115	sialic acid binding Ig-like lectin F	Mus musculus	81-89
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	0-6	sialic acid binding Ig-like lectin F	Mus musculus	88-96
29659839-1	2018	Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6"-sulfated sialyl Lewis X and 6"-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays.	Polysaccharides	210-216	sialic acid binding Ig-like lectin F	Mus musculus	0-8
27892504-2	2016	PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures.	N-Acetylneuraminic Acid	108-119	sialic acid binding Ig-like lectin F	Mus musculus	61-69
27892504-3	2016	Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.	Calcium	102-109	sialic acid binding Ig-like lectin F	Mus musculus	29-37
23840825-5	2013	METHODS: Consequences of engagement of Siglec-F on mouse eosinophils were studied by measuring ROS production, and by performing apoptosis assays using eosinophils from normal, hypereosinophilic, NADPH oxidase-deficient, src homology domain-containing protein tyrosine phosphatase (SHP)-1-deficient, and Lyn kinase-deficient mice.	Reactive Oxygen Species	95-98	sialic acid binding Ig-like lectin F	Mus musculus	39-47
25964474-8	2015	However, enhanced resistance was associated with an increase in levels of clodronate-sensitive, phagocytic SiglecF(low) alveolar macrophages within the airways following ALI.	Clodronic Acid	74-84	sialic acid binding Ig-like lectin F	Mus musculus	107-114
25497369-0	2015	Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.	Polysaccharides	31-38	sialic acid binding Ig-like lectin F	Mus musculus	49-57
25497369-3	2015	Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the identities of endogenous sialoside ligands and their glycoprotein carriers in vivo are unknown.	Polysaccharides	40-47	sialic acid binding Ig-like lectin F	Mus musculus	0-8
25497369-3	2015	Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the identities of endogenous sialoside ligands and their glycoprotein carriers in vivo are unknown.	Polysaccharides	40-46	sialic acid binding Ig-like lectin F	Mus musculus	0-8
25497369-4	2015	OBJECTIVES: To use mouse lung-derived materials to isolate, biochemically identify, and biologically characterize naturally occurring endogenous glycan ligands for Siglec-F.	Polysaccharides	145-151	sialic acid binding Ig-like lectin F	Mus musculus	164-172
25497369-8	2015	RESULTS: We detected mouse lung glycoproteins that bound to Siglec-F; binding was sialic acid dependent.	N-Acetylneuraminic Acid	82-93	sialic acid binding Ig-like lectin F	Mus musculus	60-68
25497369-13	2015	CONCLUSIONS: These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.	Polysaccharides	129-136	sialic acid binding Ig-like lectin F	Mus musculus	189-197
21970996-2	2011	Sialic acid-binding immunoglobulin-like lectin (Siglec-F) is a receptor highly expressed on mouse eosinophils and mediates eosinophilic apoptosis.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig-like lectin F	Mus musculus	48-56
23160308-1	2013	PURPOSE OF REVIEW: Siglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands.	Polysaccharides	208-214	sialic acid binding Ig-like lectin F	Mus musculus	32-40
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	63-69	sialic acid binding Ig-like lectin F	Mus musculus	35-43
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	136-142	sialic acid binding Ig-like lectin F	Mus musculus	35-43
23094217-0	2012	Effect of anti-siglec-f antibody and reactive oxygen species blocking on histamine release in urinary bladder of ovalbumin-treated mice.	Histamine	73-82	sialic acid binding Ig-like lectin F	Mus musculus	15-23
23094217-2	2012	This study aimed to evaluate the effects of anti-Siglec-F on plasma and urinary histamine levels in ovalbumin (OVA)-challenged urinary bladder in mice.	Histamine	80-89	sialic acid binding Ig-like lectin F	Mus musculus	49-57
23094217-9	2012	Pretreatment with anti-Siglec-F antibody significantly prevented the increase in urinary histamine release (P<0.05), whereas pretreatment with the IgG antibody control did not.	Histamine	89-98	sialic acid binding Ig-like lectin F	Mus musculus	23-31
23094217-11	2012	CONCLUSIONS: Systemic anti-Siglec-F treatment showed anti-allergic effects at least on local histamine release, particularly in the lower urinary bladder.	Histamine	93-102	sialic acid binding Ig-like lectin F	Mus musculus	27-35
21040544-5	2010	RESULTS: Siglec-F deficient mice challenged with OVA for one month had significantly increased numbers of BAL and peribronchial eosinophils compared to WT mice which was associated with a significant increase in mucus expression as assessed by the number of periodic acid Schiff positive airway epithelial cells.	Periodic Acid	258-271	sialic acid binding Ig-like lectin F	Mus musculus	9-17
20395633-0	2011	Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.	Polysaccharides	34-40	sialic acid binding Ig-like lectin F	Mus musculus	53-61
20395633-1	2011	Sialic acid-binding immunoglobulin-like lectin (Siglec)-F, an inhibitory receptor on mouse eosinophils, preferentially recognizes the glycan ligand 6"-sulfated sialyl Lewis X, but little is known about the requirements for its lung expression.	Polysaccharides	134-140	sialic acid binding Ig-like lectin F	Mus musculus	0-57
20395633-6	2011	Binding of the Siglec-F-Ig fusion protein was similar in pattern to, and completely blocked by, a plant lectin recognizing alpha2,3-linked sialic acid.	alpha2,3-linked sialic acid	123-150	sialic acid binding Ig-like lectin F	Mus musculus	15-23
20395633-7	2011	Thus, alpha2,3-linked sialic acid-containing glycoprotein Siglec-F ligands and the enzymes required for their synthesis are constitutively expressed in murine lungs, especially by airway epithelium.	N-Acetylneuraminic Acid	22-33	sialic acid binding Ig-like lectin F	Mus musculus	58-66
19783675-1	2009	Siglec-F is a sialic acid-binding Ig superfamily receptor that is highly expressed on eosinophils.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig-like lectin F	Mus musculus	0-8
19783675-8	2009	Administration of the anti-Siglec-F Ab modestly reduced levels of periodic acid-Schiff-positive mucus cells and the thickness of the smooth muscle layer.	Periodic Acid	66-79	sialic acid binding Ig-like lectin F	Mus musculus	27-35
17562860-6	2007	Like CD22, Siglec-F mediates endocytosis of anti-Siglec-F and sialoside ligands, a function requiring intact tyrosine-based motifs.	sialoside	62-71	sialic acid binding Ig-like lectin F	Mus musculus	11-19
19178537-8	2009	Despite only modest homology, both Siglec-8 and Siglec-F preferentially recognize a sulphated glycan ligand closely related to sialyl Lewis X, a common ligand for the selectin family of adhesion molecules.	Polysaccharides	94-100	sialic acid binding Ig-like lectin F	Mus musculus	48-56
19135419-1	2009	Siglec-F is a sialic acid binding immunoglobulin-superfamily receptor that is highly expressed on eosinophils.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig-like lectin F	Mus musculus	0-8
17562860-6	2007	Like CD22, Siglec-F mediates endocytosis of anti-Siglec-F and sialoside ligands, a function requiring intact tyrosine-based motifs.	Tyrosine	109-117	sialic acid binding Ig-like lectin F	Mus musculus	11-19
17562860-6	2007	Like CD22, Siglec-F mediates endocytosis of anti-Siglec-F and sialoside ligands, a function requiring intact tyrosine-based motifs.	Tyrosine	109-117	sialic acid binding Ig-like lectin F	Mus musculus	49-57
15972893-0	2005	Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6"-sulfo-sialyl Lewis X as a preferred glycan ligand.	Polysaccharides	170-176	sialic acid binding Ig-like lectin F	Mus musculus	6-14
15972893-1	2005	Mouse sialic acid-binding immunoglobulin-like lectin F (Siglec-F) is an eosinophil surface receptor, which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain, implicating it as a regulator of cell signaling as documented for other siglecs.	Tyrosine	134-142	sialic acid binding Ig-like lectin F	Mus musculus	6-54
15972893-1	2005	Mouse sialic acid-binding immunoglobulin-like lectin F (Siglec-F) is an eosinophil surface receptor, which contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain, implicating it as a regulator of cell signaling as documented for other siglecs.	Tyrosine	134-142	sialic acid binding Ig-like lectin F	Mus musculus	56-64
15048729-1	2004	Murine (m) Siglec-E and mSiglec-F are recently discovered murine sialic acid-binding Ig-like lectins with tyrosine-based inhibitory signaling motifs.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig-like lectin F	Mus musculus	24-33
15048729-1	2004	Murine (m) Siglec-E and mSiglec-F are recently discovered murine sialic acid-binding Ig-like lectins with tyrosine-based inhibitory signaling motifs.	Tyrosine	106-114	sialic acid binding Ig-like lectin F	Mus musculus	24-33
11579105-2	2001	Unlike most human Siglec-3 (hSiglec-3)-related Siglecs with promiscuous linkage specificity, mSiglec-F shows a strong preference for alpha2-3-linked sialic acids.	Sialic Acids	149-161	sialic acid binding Ig-like lectin F	Mus musculus	93-102
17272508-4	2007	Taken together with the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negative feedback loop, controlling allergic responses of eosinophils and helper T cells, via Siglec-F and Siglec-F ligands.	Tyrosine	24-32	sialic acid binding Ig-like lectin F	Mus musculus	81-89
17272508-4	2007	Taken together with the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negative feedback loop, controlling allergic responses of eosinophils and helper T cells, via Siglec-F and Siglec-F ligands.	Tyrosine	24-32	sialic acid binding Ig-like lectin F	Mus musculus	206-214
17272508-4	2007	Taken together with the tyrosine-based inhibitory motif in the cytosolic tail of Siglec-F, the data suggested a negative feedback loop, controlling allergic responses of eosinophils and helper T cells, via Siglec-F and Siglec-F ligands.	Tyrosine	24-32	sialic acid binding Ig-like lectin F	Mus musculus	206-214
12940982-6	2003	In addition, macrophages expressing Sn, as well as transfectants expressing Sn or siglec-5, bound and phagocytosed sialylated bacteria in a siglec- and sialic acid-dependent manner.	N-Acetylneuraminic Acid	152-163	sialic acid binding Ig-like lectin F	Mus musculus	82-90