PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34905700-4 2021 Animal and cellular studies have found that lithium salt can upregulate the expression of the clock gene Per2, but the mechanism is unknown. lithium salt 44-56 clock circadian regulator Homo sapiens 94-99 34977153-13 2021 Moreover, clock gene expression is correlated with the sensitivity of anticancer drugs such as bleomycin and methotrexate in pan-RCC. Bleomycin 95-104 clock circadian regulator Homo sapiens 10-15 34977153-13 2021 Moreover, clock gene expression is correlated with the sensitivity of anticancer drugs such as bleomycin and methotrexate in pan-RCC. Methotrexate 109-121 clock circadian regulator Homo sapiens 10-15 34904778-7 2022 We also discovered that miR-455-5p can function as a Clock modulator to induce a fine-orchestral circadian rhythm in vitro, as well as other known factors such as dexamethasone, horse serum, or temperature. mir-455-5p 24-34 clock circadian regulator Homo sapiens 53-58 34650409-0 2021 In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders. Valproic Acid 21-34 clock circadian regulator Homo sapiens 69-74 34142702-9 2021 Using GSVA and Pearson correlation, we identified 98 common pathways that were negatively or positively correlated with CLOCK and CRY2 expression (all p < 0.05, FDR < 0.10). gsva 6-10 clock circadian regulator Homo sapiens 120-125 34650409-4 2021 The objective of this study is to characterise circadian behaviour and clock-gene expression in a valproic acid (VPA)-induced animal model of autism to highlight perturbations potentially contributing to these disturbances. Valproic Acid 98-111 clock circadian regulator Homo sapiens 71-76 34650409-4 2021 The objective of this study is to characterise circadian behaviour and clock-gene expression in a valproic acid (VPA)-induced animal model of autism to highlight perturbations potentially contributing to these disturbances. Valproic Acid 113-116 clock circadian regulator Homo sapiens 71-76 34550617-0 2022 Working around the CLOCK: cocaine-induced phase shift of NPAS2 and SIRT1 and their roles in directing drug-related behavior (Commentary on Becker-Krail et al., 2021). Cocaine 26-33 clock circadian regulator Homo sapiens 19-24 34124933-3 2021 Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1beta was concomitant with elevated levels of core circadian regulators Clock and Bmal1. Lactic Acid 17-24 clock circadian regulator Homo sapiens 148-153 34365685-0 2021 Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. Melatonin 0-9 clock circadian regulator Homo sapiens 74-79 34365685-1 2021 Melatonin pleiotropically regulates physiological events and has a putative regulatory role in the circadian clock desynchrony-mediated Non-alcoholic fatty liver disease (NAFLD). Melatonin 0-9 clock circadian regulator Homo sapiens 109-114 34365685-3 2021 Melatonin treatment (100 microM) to HepG2 cells led to an improvement in oscillatory pattern of clock genes (Clock, Bmal1, and Per) in oleic acid (OA)-induced circadian desynchrony, while Cry, Nrf2, and HO-1 remain oblivious of melatonin treatment that was also validated by circwave analysis. Melatonin 0-9 clock circadian regulator Homo sapiens 96-101 34365685-3 2021 Melatonin treatment (100 microM) to HepG2 cells led to an improvement in oscillatory pattern of clock genes (Clock, Bmal1, and Per) in oleic acid (OA)-induced circadian desynchrony, while Cry, Nrf2, and HO-1 remain oblivious of melatonin treatment that was also validated by circwave analysis. Melatonin 0-9 clock circadian regulator Homo sapiens 109-114 34365685-3 2021 Melatonin treatment (100 microM) to HepG2 cells led to an improvement in oscillatory pattern of clock genes (Clock, Bmal1, and Per) in oleic acid (OA)-induced circadian desynchrony, while Cry, Nrf2, and HO-1 remain oblivious of melatonin treatment that was also validated by circwave analysis. Oleic Acid 135-145 clock circadian regulator Homo sapiens 96-101 34124933-4 2021 siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1beta levels and (ii) release of lactate and pro-inflammatory cytokines. Lactic Acid 103-110 clock circadian regulator Homo sapiens 38-43 34124933-5 2021 Lactate mediated deacetylation of Bmal1 and its interaction with Clock, regulate IL-1beta levels and vice versa. Lactic Acid 0-7 clock circadian regulator Homo sapiens 65-70 34124933-9 2021 Lactate-IL-1beta-Clock (LIC) loop positively regulated expression of genes associated with cell cycle, DNA damage and cytoskeletal organization involved in glioma progression. Lactic Acid 0-7 clock circadian regulator Homo sapiens 17-22 34124933-13 2021 Our findings provide evidence for a potential cancer-specific axis wiring of IL-1beta and LDHA through Clock -Bmal1, the outcome of which is to fuel an IL-1beta-lactate autocrine loop that drives pro-inflammatory and oncogenic signals. Lactic Acid 161-168 clock circadian regulator Homo sapiens 103-108 35090555-0 2022 Core clock regulators in dexamethasone-treated HEK 293T cells at 4 h intervals. Dexamethasone 25-38 clock circadian regulator Homo sapiens 5-10 34131827-13 2021 In conclusion, these findings suggested that the CLOCK-dependent rapamycin signaling pathway is a critical mediator in ox-LDL-induced VSMCs with defective autophagy that exacerbates plaque destabilization. Sirolimus 65-74 clock circadian regulator Homo sapiens 49-54 34068889-0 2021 CLOCK Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids. Fatty Acids, Monounsaturated 89-116 clock circadian regulator Homo sapiens 0-5 34068889-2 2021 The objective of this study was to investigate the association between CLOCK rs1801260 and the incidence of metabolic syndrome modulated by dietary monounsaturated fatty acid (MUFA) intake in Korean adults. dietary monounsaturated fatty acid 140-174 clock circadian regulator Homo sapiens 71-76 34068889-2 2021 The objective of this study was to investigate the association between CLOCK rs1801260 and the incidence of metabolic syndrome modulated by dietary monounsaturated fatty acid (MUFA) intake in Korean adults. Fatty Acids, Monounsaturated 176-180 clock circadian regulator Homo sapiens 71-76 34068889-5 2021 By dichotomizing dietary MUFA intake, we observed that men who were minor allele carriers (G allele) of CLOCK rs1801260 had a 42% increased incidence of metabolic syndrome when dietary MUFA intake was <=3.5% (HR: 1.42, 95% CI 1.23-1.81; p Value = 0.004). Fatty Acids, Monounsaturated 25-29 clock circadian regulator Homo sapiens 104-109 34068889-7 2021 CLOCK polymorphisms affected metabolic syndrome, modulated by dietary MUFA intake in men. Fatty Acids, Monounsaturated 70-74 clock circadian regulator Homo sapiens 0-5 34068889-8 2021 These results suggest the significance of CLOCK genes in the pathogenesis of metabolic syndrome and the modulating role of dietary MUFA intake and provide new insights into the underlying mechanisms connecting the circadian system, dietary factors, and metabolic syndrome. Fatty Acids, Monounsaturated 131-135 clock circadian regulator Homo sapiens 42-47 35628429-0 2022 Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells. piperine 0-8 clock circadian regulator Homo sapiens 78-83 35628429-6 2022 The effect of PIP on redox status, mitochondrial functions, and circadian rhythms of core clock genes were evaluated. piperine 14-17 clock circadian regulator Homo sapiens 90-95 35628429-8 2022 A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells. piperine 30-33 clock circadian regulator Homo sapiens 120-125 35628429-9 2022 These results indicated that Bmal1 and Clock played important roles in the regulating effect of PIP on hepatic lipid homeostasis. piperine 96-99 clock circadian regulator Homo sapiens 39-44 35560862-0 2022 Effect of a hyaluronic acid based mesotherapeutic injectable on the gene expression of CLOCK and Klotho proteins, and environmentally induced oxidative stress in human skin cells. Hyaluronic Acid 12-27 clock circadian regulator Homo sapiens 87-92 35072523-7 2022 Here, we discuss the role of the circadian clock and rhythms in mitochondria on ROS homeostasis. Reactive Oxygen Species 80-83 clock circadian regulator Homo sapiens 43-48 35072523-8 2022 Circadian clock is involved in mitochondrial ROS production and detoxification through control of nutrient flux and oxidation, uncoupling, antioxidant defense and mitochondrial dynamics. Reactive Oxygen Species 45-48 clock circadian regulator Homo sapiens 10-15 35465929-3 2022 This chapter describes the use of SDSL in quantifying KaiB-KaiC binding in the cyanobacterial circadian clock (Kai Clock), exploiting the changes in mobility of the local environment around the spin label on KaiB-KaiC interactions. sdsl 34-38 clock circadian regulator Homo sapiens 104-109 35465929-3 2022 This chapter describes the use of SDSL in quantifying KaiB-KaiC binding in the cyanobacterial circadian clock (Kai Clock), exploiting the changes in mobility of the local environment around the spin label on KaiB-KaiC interactions. sdsl 34-38 clock circadian regulator Homo sapiens 115-120 34273024-6 2021 Remdesivir leads to a slight phase-shift in Clock, Per1 and Per2. remdesivir 0-10 clock circadian regulator Homo sapiens 44-49 34073760-0 2021 Development of Non-Ethoxypropanoic Acid Type Cryptochrome Inhibitors with Circadian Molecular Clock-Enhancing Activity by Bioisosteric Replacement. ethoxypropanoic acid 19-39 clock circadian regulator Homo sapiens 94-99 34973011-1 2021 Glucocorticoids are ubiquitous, pleotropic steroid hormones secreted from the cortices of the adrenal glands in a circadian fashion under the strong influence of the central Clock center located in the suprachiasmatic nuclei (SCN) of the hypothalamus. Steroids 43-50 clock circadian regulator Homo sapiens 174-179 34973011-2 2021 In previous work, we reported that the circadian transcription factor CLOCK and its heterodimer partner BMAL1 suppress the transcriptional activity of the glucocorticoid receptor (GR) by acetylating a lysine cluster located in its hinge region between the DNA- and ligand-binding domains. Lysine 201-207 clock circadian regulator Homo sapiens 70-75 35616339-8 2022 The circadian metabolite, NAD+ , serves as a crucial link connecting clock genes to sirtuin activity. NAD 26-30 clock circadian regulator Homo sapiens 69-74 35616339-9 2022 This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins. NAD 58-62 clock circadian regulator Homo sapiens 114-119 35616339-9 2022 This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins. NAD 130-134 clock circadian regulator Homo sapiens 114-119 35616339-11 2022 Thus, the Clock-NAD+-Sirtuin connection represents a novel "feedback loop" circuit that regulates the metabolic machinery. NAD 16-20 clock circadian regulator Homo sapiens 10-15 35616339-12 2022 The current review underpins the importance of NAD+ on the sirtuin and clock connection in preventing fatty liver disorder. NAD 47-51 clock circadian regulator Homo sapiens 71-76 35145399-3 2021 Based on our previous report, we tested the hypothesis that the human circadian locomotor output cycles kaput (CLOCK) gene polymorphisms play a role in the response to caffeine citrate therapy in preterm infants. caffeine citrate 168-184 clock circadian regulator Homo sapiens 70-109 35145399-3 2021 Based on our previous report, we tested the hypothesis that the human circadian locomotor output cycles kaput (CLOCK) gene polymorphisms play a role in the response to caffeine citrate therapy in preterm infants. caffeine citrate 168-184 clock circadian regulator Homo sapiens 111-116 35145399-11 2021 Of the 46 candidate SNPs in the CLOCK gene, 26 were found to be associated with determining the response to caffeine treatment in these babies. Caffeine 108-116 clock circadian regulator Homo sapiens 32-37 35145399-13 2021 Moreover, strong LD formed in those variants in AHR, ADORA2A, and CLOCK genes was confirmed to be significantly associated with a better response to standard-dose caffeine therapy. Caffeine 163-171 clock circadian regulator Homo sapiens 66-71 35145399-14 2021 In summary, CLOCK gene polymorphisms play a role in determining the response to caffeine therapy in premature neonates with AOP. Caffeine 80-88 clock circadian regulator Homo sapiens 12-17 35145399-15 2021 However, whether the AHR and CLOCK signaling pathways crosstalk with each other during caffeine treatment remains largely unclear. Caffeine 87-95 clock circadian regulator Homo sapiens 29-34 35090555-2 2022 Among the various established synchronizers of the circadian clock in cell culture (temperature, serum shock, glucocorticoids), the artificial glucocorticoid Dexamethasone (DEX) is the most widely used. Dexamethasone 158-171 clock circadian regulator Homo sapiens 61-66 35090555-2 2022 Among the various established synchronizers of the circadian clock in cell culture (temperature, serum shock, glucocorticoids), the artificial glucocorticoid Dexamethasone (DEX) is the most widely used. Dexamethasone 173-176 clock circadian regulator Homo sapiens 61-66 35090555-3 2022 DEX treatment as a protocol to reset the circadian clock in culture gives simple readout with minimal laboratory requirements. Dexamethasone 0-3 clock circadian regulator Homo sapiens 51-56 35090555-4 2022 Even though there are many studies regarding clock resetting in culture using DEX, reference points or expression patterns of core clock genes and their protein products are scarce and sometimes contradict other works with similar methodology. Dexamethasone 78-81 clock circadian regulator Homo sapiens 45-50 34045944-0 2021 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics. Calcium 32-39 clock circadian regulator Homo sapiens 64-69 34045944-0 2021 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics. Calcium 89-96 clock circadian regulator Homo sapiens 64-69 33450259-0 2021 Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux. Reactive Oxygen Species 27-50 clock circadian regulator Homo sapiens 0-5 33388853-2 2021 Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clock with clock-controlled oscillatory protein, NAMPT, and its metabolite NAD+. NAD 185-189 clock circadian regulator Homo sapiens 110-115 33404366-4 2021 Here, we introduce cellular clock biology as a novel mechanism linking early oxygen exposure to airway biology. Oxygen 77-83 clock circadian regulator Homo sapiens 28-33 33404366-7 2021 We hypothesized that hyperoxia impacts clock function in fASM and that the clock can be leveraged to attenuate deleterious effects of O2 on the developing airway. Oxygen 134-136 clock circadian regulator Homo sapiens 75-80 33404366-8 2021 We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2. Dexamethasone 116-129 clock circadian regulator Homo sapiens 39-44 33404366-8 2021 We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2. Dexamethasone 116-129 clock circadian regulator Homo sapiens 87-92 33404366-8 2021 We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2. Oxygen 145-147 clock circadian regulator Homo sapiens 39-44 33404366-8 2021 We report that human fASM express core clock machinery (PER1, PER2, CRY1, ARNTL/BMAL1, CLOCK) that is responsive to dexamethasone and altered by O2. Oxygen 145-147 clock circadian regulator Homo sapiens 87-92 33404366-9 2021 Disruption of the clock via siRNA-mediated PER1 or ARNTL knockdown alters store-operated calcium entry (SOCE) and [Ca2+]i response to histamine in hyperoxia. Calcium 89-96 clock circadian regulator Homo sapiens 18-23 33404366-9 2021 Disruption of the clock via siRNA-mediated PER1 or ARNTL knockdown alters store-operated calcium entry (SOCE) and [Ca2+]i response to histamine in hyperoxia. Histamine 134-143 clock circadian regulator Homo sapiens 18-23 33388853-4 2021 This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK. NAD 33-36 clock circadian regulator Homo sapiens 163-168 33388853-4 2021 This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK. NAD 33-36 clock circadian regulator Homo sapiens 176-181 33028758-2 2021 Fluctuations of Bmal1, Clock, Per2 and Cry1 mRNA levels were found in H295R cells treated with forskolin (FSK) in a serum-free condition. Colforsin 106-109 clock circadian regulator Homo sapiens 23-28 33404366-10 2021 Effects of O2 on [Ca2+]i are rescued by driving expression of clock proteins, via effects on the Ca2+ channels IP3R and Orai1. Oxygen 11-13 clock circadian regulator Homo sapiens 62-67 33028758-2 2021 Fluctuations of Bmal1, Clock, Per2 and Cry1 mRNA levels were found in H295R cells treated with forskolin (FSK) in a serum-free condition. Colforsin 95-104 clock circadian regulator Homo sapiens 23-28 33028758-3 2021 The changes of clock gene expression levels were diverged, with Clock mRNA level being significantly higher than Cry1 and Per2 mRNA levels after 12-h stimulation with FSK. Colforsin 167-170 clock circadian regulator Homo sapiens 15-20 33028758-3 2021 The changes of clock gene expression levels were diverged, with Clock mRNA level being significantly higher than Cry1 and Per2 mRNA levels after 12-h stimulation with FSK. Colforsin 167-170 clock circadian regulator Homo sapiens 64-69 33028758-6 2021 Knockdown of Clock gene by siRNA led to a significant reduction of FSK-induced expression of StAR and CYP17 after 12-h treatment with FSK. Colforsin 67-70 clock circadian regulator Homo sapiens 13-18 33028758-6 2021 Knockdown of Clock gene by siRNA led to a significant reduction of FSK-induced expression of StAR and CYP17 after 12-h treatment with FSK. Colforsin 134-137 clock circadian regulator Homo sapiens 13-18 33028758-8 2021 Collectively, the results indicated that changes of Clock mRNA expression, being upregulated by FSK and suppressed by BMP-6 and activin, were tightly linked to StAR expression by human adrenocortical cells. Colforsin 96-99 clock circadian regulator Homo sapiens 52-57 32896064-6 2021 RESULTS: CLOCK T3111C was detected in 47% of cases (21 SCD, 11 MCI), PER2 C111G in 19% of cases (8 SCD and 5 MCI). t3111c 15-21 clock circadian regulator Homo sapiens 9-14 33596936-11 2021 Our calculations show that the mechanisms proposed by experimentalists by which REV-ERB, ROR, and BMAL1-CLOCK influence the DA system are sufficient to explain the circadian oscillations observed in dopaminergic variables. Dopamine 124-126 clock circadian regulator Homo sapiens 104-109 33513987-3 2021 A significant association between PM10 exposure and the methylation of clock genes was found, namely, this was negative for PER2 gene and positive for the CLOCK, CRY1, CRY2, and PER3 genes. pm10 34-38 clock circadian regulator Homo sapiens 71-76 33513987-3 2021 A significant association between PM10 exposure and the methylation of clock genes was found, namely, this was negative for PER2 gene and positive for the CLOCK, CRY1, CRY2, and PER3 genes. pm10 34-38 clock circadian regulator Homo sapiens 155-160 33328229-0 2020 S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling. Methionine 42-52 clock circadian regulator Homo sapiens 81-86 33125096-0 2020 Epigallocatechin-3-gallate inhibits self-renewal ability of lung cancer stem-like cells through inhibition of CLOCK. epigallocatechin gallate 0-26 clock circadian regulator Homo sapiens 110-115 31510864-15 2020 Light therapy as well as melatonin treatment could reduce the impact of ICU stay period in biological clock, thereby improving patients" recovery. Melatonin 25-34 clock circadian regulator Homo sapiens 102-107 33038659-5 2020 SIRT1 that is an NAD+-dependent deacetylase positively regulates circadian clock and telomere homeostasis. NAD 17-20 clock circadian regulator Homo sapiens 75-80 33125096-12 2020 EGCG was found to repress CLOCK expression in A549 and H1299 sphere cells. epigallocatechin gallate 0-4 clock circadian regulator Homo sapiens 26-31 33125096-15 2020 Subsequently, using a xenograft model, it was demonstrated that EGCG suppressed the CSC-like characteristics of lung cancer cells by targeting CLOCK. epigallocatechin gallate 64-68 clock circadian regulator Homo sapiens 143-148 33125096-16 2020 In conclusion, the present study demonstrated that EGCG inhibited the self-renewal ability of lung cancer stem-like cells by targeting CLOCK. epigallocatechin gallate 51-55 clock circadian regulator Homo sapiens 135-140 32763264-0 2020 Mitochondrial calcium drives clock gene-dependent activation of pyruvate dehydrogenase and of oxidative phosphorylation. Calcium 14-21 clock circadian regulator Homo sapiens 29-34 33106509-5 2020 These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Desflurane 59-69 clock circadian regulator Homo sapiens 102-107 33114015-6 2020 We demonstrate that the over-expression of CLOCK and BMAL1 significantly suppresses aerobic glycolysis and lactate production by the reduction in hexokinase 1 (HK1) and lactate dehydrogenase A (LDHA) protein levels in human astrocytes. Lactic Acid 107-114 clock circadian regulator Homo sapiens 43-48 33194597-2 2020 Emerging evidence has demonstrated that the circadian clock system regulates cell-signaling pathways critical to cancer cell proliferation, survival and metastasis, meaning that it could be a good candidate for TNBC treatment. tnbc 211-215 clock circadian regulator Homo sapiens 54-59 32908891-11 2020 The logistic regression results suggested that CLOCK gene rs1801260 (TC) and positive psychological symptoms were influential factors for sleep disorders, and the interaction of positive psychological symptoms*rs1801260 (TT) was a risk factor for sleep disorders (OR = 10.833, 95% CI: 2.987-39.288). Technetium 69-71 clock circadian regulator Homo sapiens 47-52 32969426-2 2020 Screening of a chemical library identified 5,8-quinoxalinedione (1), which was found to inhibit binding of the heterodimer BMAL1/CLOCK to E-box at low micromolar concentrations. Quinoxaline-5,8-dione 43-63 clock circadian regulator Homo sapiens 129-134 32503923-3 2020 Oncomine datamining revealed downregulation of multiple members of the circadian clock gene family in cancer patient tissue compared to matched normal epithelium. oncomine 0-8 clock circadian regulator Homo sapiens 81-86 33364523-0 2020 Cisplatin"s dual-effect on the circadian clock triggers proliferation and apoptosis. Cisplatin 0-9 clock circadian regulator Homo sapiens 41-46 32823749-2 2020 Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. Oxygen 65-71 clock circadian regulator Homo sapiens 98-103 33364523-1 2020 The circadian clock, which generates the internal daily rhythm largely mediated through release of melatonin, can be disrupted in various ways. Melatonin 99-108 clock circadian regulator Homo sapiens 14-19 33364523-3 2020 Cisplatin modulates the circadian clock through two mechanisms: 1) the circadian clock control of DNA excision repair and 2) the effect of circadian clock disruption on apoptosis. Cisplatin 0-9 clock circadian regulator Homo sapiens 34-39 33364523-3 2020 Cisplatin modulates the circadian clock through two mechanisms: 1) the circadian clock control of DNA excision repair and 2) the effect of circadian clock disruption on apoptosis. Cisplatin 0-9 clock circadian regulator Homo sapiens 81-86 33364523-3 2020 Cisplatin modulates the circadian clock through two mechanisms: 1) the circadian clock control of DNA excision repair and 2) the effect of circadian clock disruption on apoptosis. Cisplatin 0-9 clock circadian regulator Homo sapiens 81-86 33364523-7 2020 Cisplatin has a dual-effect on circadian genes: upregulation of CLOCK expression causes an increase in proliferation but upregulation of BMAL1 expression causes an increase in apoptosis. Cisplatin 0-9 clock circadian regulator Homo sapiens 64-69 32354240-1 2020 In Cushing"s syndrome, the cortisol rhythm is impaired and can be associated with the disruption in the rhythmic expression of clock genes. Hydrocortisone 27-35 clock circadian regulator Homo sapiens 127-132 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 240-253 clock circadian regulator Homo sapiens 16-21 31864078-0 2020 Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract. Acrolein 0-8 clock circadian regulator Homo sapiens 70-75 31864078-4 2020 However, whether acrolein, an environmental pollutant, affects the apoptosis of VSMCs by regulating NEAT1 and clock genes is still elusive. Acrolein 17-25 clock circadian regulator Homo sapiens 110-115 31864078-8 2020 Expression of NEAT1, Bmal1 and Clock was decreased by acrolein, while was ameliorated by AE. Acrolein 54-62 clock circadian regulator Homo sapiens 31-36 31864078-12 2020 In this study, we demonstrated that VSMCs apoptosis induced by acrolein was associated with downregulation of NEAT1 and Bmal1/Clock. Acrolein 63-71 clock circadian regulator Homo sapiens 126-131 31613643-0 2020 Influence of Obesity, Weight Loss, and Free Fatty Acids on Skeletal Muscle Clock Gene Expression. Fatty Acids 44-55 clock circadian regulator Homo sapiens 75-80 31613643-10 2020 Circadian time-course studies revealed that core clock genes oscillate over time (P<0.05), with BMAL1, CIART, CRY2, DBP, PER1 and PER3 expression profiles altered by palmitate treatment. Palmitates 169-178 clock circadian regulator Homo sapiens 49-54 31613643-12 2020 Palmitate exposure disrupts clock gene expression in myotubes, indicating dyslipidemia directly alters the circadian program. Palmitates 0-9 clock circadian regulator Homo sapiens 28-33 32325849-0 2020 Polymorphism of CLOCK Gene rs3749474 as a Modulator of the Circadian Evening Carbohydrate Intake Impact on Nutritional Status in an Adult Sample. Carbohydrates 77-89 clock circadian regulator Homo sapiens 16-21 32101164-0 2020 Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Serine 16-22 clock circadian regulator Homo sapiens 80-91 32101164-4 2020 However, we find that CRY1 is recruited with much higher affinity to the PAS domain core of CLOCK:BMAL1, allowing it to serve as a stronger repressor that lengthens circadian period. Protactinium 73-76 clock circadian regulator Homo sapiens 92-103 32101164-5 2020 We discovered a dynamic serine-rich loop adjacent to the secondary pocket in the photolyase homology region (PHR) domain that regulates differential binding of cryptochromes to the PAS domain core of CLOCK:BMAL1. Serine 24-30 clock circadian regulator Homo sapiens 200-205 32101164-6 2020 Notably, binding of the co-repressor PER2 remodels the serine loop of CRY2, making it more CRY1-like and enhancing its affinity for CLOCK:BMAL1. Serine 55-61 clock circadian regulator Homo sapiens 132-137 32468460-5 2020 Our results indicate that elevated cortisol levels play an important role in stress, inflammation, and sleep disorders as a result of prolonged and stronger dsDNA - Clock/Bmal1 interactions. Hydrocortisone 35-43 clock circadian regulator Homo sapiens 165-176 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 265-278 clock circadian regulator Homo sapiens 143-148 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 265-278 clock circadian regulator Homo sapiens 143-148 32705594-6 2020 Circadian clock genes affect the regulation of transporters and proteins included in the regulation of phospholipid metabolism. Phospholipids 103-115 clock circadian regulator Homo sapiens 10-15 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 240-253 clock circadian regulator Homo sapiens 143-148 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 240-253 clock circadian regulator Homo sapiens 143-148 32705594-5 2020 Among circadian clock genes, numerous metabolic syndromes are the most important in the regulation of food intake (via regulation of circadian clock genes or clock-controlled genes in peripheral tissue), which lead to a variation in plasma phospholipids and tissue phospholipids. Phospholipids 265-278 clock circadian regulator Homo sapiens 16-21 30518737-2 2019 Similarities between changes in the mRNA and protein expression levels of Bmal1 and Clock and those of Per2 and Cry1 were found in KGN cells after treatment with forskolin. Colforsin 162-171 clock circadian regulator Homo sapiens 84-89 31674727-0 2019 Serotonin Prevents Differentiation of Brown Adipocytes by Interfering with Their Clock. Serotonin 0-9 clock circadian regulator Homo sapiens 81-86 31674727-3 2019 The aim of this study was to investigate whether serotonin abrogates brown adipogenesis by affecting clock functionality. Serotonin 49-58 clock circadian regulator Homo sapiens 101-106 31674727-7 2019 Serotonin in the differentiation cocktail led to reduced brown adipocyte markers as well as clock gene expression. Serotonin 0-9 clock circadian regulator Homo sapiens 92-97 31674727-9 2019 Addition of serotonin to the differentiation medium or addition after differentiation reduced activity of calcium/calmodulin-dependent protein kinase type II subunit gamma, which interferes with circadian locomoter output cycles protein kaput (CLOCK):BMAL1 dimerization and transactivation. Serotonin 12-21 clock circadian regulator Homo sapiens 244-249 31674727-10 2019 CONCLUSIONS: Clock expression is required at the early stages of differentiation to brown adipocytes, and serotonin interferes with this process by modulating clock functionality. Serotonin 106-115 clock circadian regulator Homo sapiens 159-164 31674727-11 2019 Serotonin interferes with clock functionality by reducing the levels of the active form of calcium/calmodulin-dependent protein kinase type II subunit gamma. Serotonin 0-9 clock circadian regulator Homo sapiens 26-31 31455674-3 2019 Downregulation of BMAL1 or CLOCK in GSCs induced cell-cycle arrest and apoptosis. gscs 36-40 clock circadian regulator Homo sapiens 27-32 31455674-5 2019 Targeting BMAL1 or CLOCK attenuated mitochondrial metabolic function and reduced expression of tricarboxylic acid cycle enzymes. Tricarboxylic Acids 95-113 clock circadian regulator Homo sapiens 19-24 29728703-4 2019 Furthermore, CLOCK and SIRT1 are important for regulating cocaine reward and dopaminergic (DAergic) activity, with interesting differences depending on whether DAergic activity is in a heightened state and if there is a functional CLOCK protein. Cocaine 58-65 clock circadian regulator Homo sapiens 13-18 29728703-4 2019 Furthermore, CLOCK and SIRT1 are important for regulating cocaine reward and dopaminergic (DAergic) activity, with interesting differences depending on whether DAergic activity is in a heightened state and if there is a functional CLOCK protein. Cocaine 58-65 clock circadian regulator Homo sapiens 231-236 31527239-0 2019 Heme binding to human CLOCK affects interactions with the E-box. Heme 0-4 clock circadian regulator Homo sapiens 22-27 31527239-4 2019 In this work we examine the interaction of heme with human CLOCK (hCLOCK). Heme 43-47 clock circadian regulator Homo sapiens 59-64 31527239-4 2019 In this work we examine the interaction of heme with human CLOCK (hCLOCK). Heme 43-47 clock circadian regulator Homo sapiens 66-72 31527239-8 2019 Using DNA binding assays, we demonstrate that heme disrupts binding of CLOCK to its E-box DNA target. Heme 46-50 clock circadian regulator Homo sapiens 71-76 31527239-10 2019 Within the hCLOCK structural framework, this would provide a mechanism for heme-dependent transcriptional regulation. Heme 75-79 clock circadian regulator Homo sapiens 11-17 31265956-5 2019 Interestingly, acrolein exposure contributed to the increased MMP9, decreased Clock and Bmal1, and activated MAPK pathways in human umbilical vein endothelial cells (HUVECs). Acrolein 15-23 clock circadian regulator Homo sapiens 78-83 31265956-11 2019 Therefore, our findings indicated that acrolein increased the expression of MMP9 through MAPK regulating circadian clock, which was associated with gut microbiota regulation in atherosclerosis. Acrolein 39-47 clock circadian regulator Homo sapiens 115-120 31613643-13 2020 Strategies to reduce lipid overload and prevent elevations in NEFA and cholesterol levels may sustain circadian clock signals in skeletal muscle. Cholesterol 71-82 clock circadian regulator Homo sapiens 112-117 31173767-4 2019 We observed that cell proliferation of human umbilical vein endothelial cells (HUVECs) was inhibited after exposed to TMAO for 24 h. Besides, TMAO caused increased expression of lncRNA-NEAT1, Clock and Bmal1, and inhibited MAPK pathways. trimethyloxamine 118-122 clock circadian regulator Homo sapiens 192-197 31173767-4 2019 We observed that cell proliferation of human umbilical vein endothelial cells (HUVECs) was inhibited after exposed to TMAO for 24 h. Besides, TMAO caused increased expression of lncRNA-NEAT1, Clock and Bmal1, and inhibited MAPK pathways. trimethyloxamine 142-146 clock circadian regulator Homo sapiens 192-197 31173767-9 2019 Moreover, it ameliorated the disorders of NEAT1, Clock, Bmal1, and MAPK signaling pathways induced by TMAO. trimethyloxamine 102-106 clock circadian regulator Homo sapiens 49-54 31173767-10 2019 Therefore, our findings indicated that NEAT1 regulating Clock-Bmal1 via MAPK pathways was involved in TMAO-repressed HUVECs proliferation, and AE improved endothelial proliferation by TMAO, proposing a novel mechanism for cardiovascular disease prevention. trimethyloxamine 102-106 clock circadian regulator Homo sapiens 56-61 31173767-10 2019 Therefore, our findings indicated that NEAT1 regulating Clock-Bmal1 via MAPK pathways was involved in TMAO-repressed HUVECs proliferation, and AE improved endothelial proliferation by TMAO, proposing a novel mechanism for cardiovascular disease prevention. trimethyloxamine 184-188 clock circadian regulator Homo sapiens 56-61 31379749-5 2019 Evidence about how cholesterol/oxysterol pathways are intertwined with circadian clock is building. Cholesterol 19-30 clock circadian regulator Homo sapiens 81-86 31379749-5 2019 Evidence about how cholesterol/oxysterol pathways are intertwined with circadian clock is building. Oxysterols 31-40 clock circadian regulator Homo sapiens 81-86 31379749-7 2019 RORs and LXRs are both regulated by sterols/oxysterols and the circadian clock and in return also regulate the same pathways, representing a complex interplay between sterol metabolism and the clock. Sterols 36-42 clock circadian regulator Homo sapiens 193-198 30518737-6 2019 Thus, the expression levels of Clock, being upregulated by forskolin and BMP-7, were functionally linked to estradiol production and progesterone suppression by human granulosa cells. Colforsin 59-68 clock circadian regulator Homo sapiens 31-36 30518737-6 2019 Thus, the expression levels of Clock, being upregulated by forskolin and BMP-7, were functionally linked to estradiol production and progesterone suppression by human granulosa cells. Estradiol 108-117 clock circadian regulator Homo sapiens 31-36 30518737-6 2019 Thus, the expression levels of Clock, being upregulated by forskolin and BMP-7, were functionally linked to estradiol production and progesterone suppression by human granulosa cells. Progesterone 133-145 clock circadian regulator Homo sapiens 31-36 30518737-4 2019 Knockdown of Clock gene by siRNA resulted in a significant reduction of estradiol production by inhibiting P450arom expression, while it induced a significant increase of progesterone production by upregulating 3betaHSD in KGN cells treated with forskolin. Estradiol 72-81 clock circadian regulator Homo sapiens 13-18 30518737-4 2019 Knockdown of Clock gene by siRNA resulted in a significant reduction of estradiol production by inhibiting P450arom expression, while it induced a significant increase of progesterone production by upregulating 3betaHSD in KGN cells treated with forskolin. Progesterone 171-183 clock circadian regulator Homo sapiens 13-18 30518737-4 2019 Knockdown of Clock gene by siRNA resulted in a significant reduction of estradiol production by inhibiting P450arom expression, while it induced a significant increase of progesterone production by upregulating 3betaHSD in KGN cells treated with forskolin. Colforsin 246-255 clock circadian regulator Homo sapiens 13-18 30003419-0 2018 Association of 3111T/C Polymorphism of the Clock Gene with Circadian Rhythm of Melatonin in Menopausal Women with Insomnia. Melatonin 79-88 clock circadian regulator Homo sapiens 43-48 30132511-2 2018 Recent studies have suggested that the disorders of triglycerides, gluconeogenesis and liver glucose metabolism are associated with the abnormal transcription of clock genes. Triglycerides 52-65 clock circadian regulator Homo sapiens 162-167 29860109-0 2018 Loss of CLOCK under high glucose upregulates ROCK1-mediated endothelial to mesenchymal transition and aggravates plaque vulnerability. Glucose 25-32 clock circadian regulator Homo sapiens 8-13 29985456-0 2018 Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation. Melatonin 127-136 clock circadian regulator Homo sapiens 27-32 29985456-5 2018 Here we studied peripheral oscillators in peripheral blood mononuclear cells (PBMCs) in males with tetraplegia by examining how exogenous melatonin may influence the expression of clock gene mRNAs. Melatonin 138-147 clock circadian regulator Homo sapiens 180-185 30106783-0 2018 Xenon Myocardial Protection in Cardiac Surgery: Effective around the Clock? Xenon 0-5 clock circadian regulator Homo sapiens 69-74 29588368-2 2018 Although several phosphorylation sites on CLOCK have already been identified, this study characterizes a novel phosphorylation site at serine 845 (Ser-836 in humans). Serine 135-141 clock circadian regulator Homo sapiens 42-47 29844814-0 2018 Association between circadian gene CLOCK and cisplatin resistance in ovarian cancer cells: A preliminary study. Cisplatin 45-54 clock circadian regulator Homo sapiens 35-40 29351477-8 2018 Furthermore, simulating the impact of Clock gene knockout suggests that modification to the local pathways tied most closely to the feeding-fasting rhythms may be the most efficient way to restore the disrupted glucose metabolism in liver. Glucose 211-218 clock circadian regulator Homo sapiens 38-43 29577261-10 2018 Clock genes and especially BMAL1 showed an important role in fertility, whereas oestradiol and androgens exhibited tissue-specific effects on clock gene expression. Estradiol 80-90 clock circadian regulator Homo sapiens 142-147 29844814-2 2018 The expression of CLOCK mRNA and protein in cisplatin-sensitive A2780 and cisplatin-resistant CP70 cells were detected by quantitative polymerase chain reaction and western blot assay. Cisplatin 74-83 clock circadian regulator Homo sapiens 18-23 29844814-3 2018 Cisplatin-sensitive A2780 and cisplatin-resistant CP70 cells were treated with different concentrations of cisplatin for 48 h, and the expression of hCLOCK protein in the two types of cells was detected by western blot assay. Cisplatin 0-9 clock circadian regulator Homo sapiens 149-155 29844814-1 2018 The present study aimed to observe the expression of circadian gene clock circadian regulator (CLOCK) in ovarian cancer cells and the effects of circadian gene CLOCK on cis-dichlorodiamine platinum (cisplatin) resistance in ovarian cancer cells. Cisplatin 169-197 clock circadian regulator Homo sapiens 160-165 29844814-3 2018 Cisplatin-sensitive A2780 and cisplatin-resistant CP70 cells were treated with different concentrations of cisplatin for 48 h, and the expression of hCLOCK protein in the two types of cells was detected by western blot assay. Cisplatin 30-39 clock circadian regulator Homo sapiens 149-155 29844814-4 2018 RNA interference method was used to knock down the expression of CLOCK in cisplatin-resistant CP70 cells. Cisplatin 74-83 clock circadian regulator Homo sapiens 65-70 29844814-1 2018 The present study aimed to observe the expression of circadian gene clock circadian regulator (CLOCK) in ovarian cancer cells and the effects of circadian gene CLOCK on cis-dichlorodiamine platinum (cisplatin) resistance in ovarian cancer cells. Cisplatin 199-208 clock circadian regulator Homo sapiens 160-165 29844814-7 2018 The expression of CLOCK mRNA was significantly higher in cisplatin-resistant CP70 cells (1.58+-0.49) compared with cisplatin-sensitive A2780 cells (0.44+-0.13) (P<0.01). Cisplatin 57-66 clock circadian regulator Homo sapiens 18-23 29844814-7 2018 The expression of CLOCK mRNA was significantly higher in cisplatin-resistant CP70 cells (1.58+-0.49) compared with cisplatin-sensitive A2780 cells (0.44+-0.13) (P<0.01). Cisplatin 115-124 clock circadian regulator Homo sapiens 18-23 29844814-8 2018 Western blot assay results demonstrated that the expression of CLOCK protein was significantly greater in the cisplatin-resistant CP70 cells (1.47+-0.34) compared with the cisplatin-sensitive A2780 cells (0.48+-0.15) (P<0.01). Cisplatin 110-119 clock circadian regulator Homo sapiens 63-68 29844814-8 2018 Western blot assay results demonstrated that the expression of CLOCK protein was significantly greater in the cisplatin-resistant CP70 cells (1.47+-0.34) compared with the cisplatin-sensitive A2780 cells (0.48+-0.15) (P<0.01). Cisplatin 172-181 clock circadian regulator Homo sapiens 63-68 29844814-9 2018 Following the treatment of A2780 and CP70 cells with cisplatin, CLOCK protein expression increased with an increased concentration of cisplatin, in a dose-dependent manner (P<0.01). Cisplatin 53-62 clock circadian regulator Homo sapiens 64-69 29844814-9 2018 Following the treatment of A2780 and CP70 cells with cisplatin, CLOCK protein expression increased with an increased concentration of cisplatin, in a dose-dependent manner (P<0.01). Cisplatin 134-143 clock circadian regulator Homo sapiens 64-69 29844814-10 2018 Following the knockdown of CLOCK in cisplatin-resistant CP70 cells by RNA interference, cisplatin treatment was able to significantly inhibit the proliferation of cells and induce apoptosis (P<0.01). Cisplatin 36-45 clock circadian regulator Homo sapiens 27-32 29844814-10 2018 Following the knockdown of CLOCK in cisplatin-resistant CP70 cells by RNA interference, cisplatin treatment was able to significantly inhibit the proliferation of cells and induce apoptosis (P<0.01). Cisplatin 88-97 clock circadian regulator Homo sapiens 27-32 29844814-11 2018 The expression of circadian gene CLOCK in ovarian cancer cells was strongly associated with cisplatin resistance. Cisplatin 92-101 clock circadian regulator Homo sapiens 33-38 29844814-2 2018 The expression of CLOCK mRNA and protein in cisplatin-sensitive A2780 and cisplatin-resistant CP70 cells were detected by quantitative polymerase chain reaction and western blot assay. Cisplatin 44-53 clock circadian regulator Homo sapiens 18-23 29892224-11 2018 Analysis of circadian clock machinery revealed that melatonin or SR9009 exposure upregulated BMAL1, CLOCK, PER2, CRY1, and RORalpha expression, with a higher effect of combined treatment. Melatonin 52-61 clock circadian regulator Homo sapiens 22-27 29844814-12 2018 The upregulation of circadian gene CLOCK in ovarian cancer cells may reduce its sensitivity to cisplatin treatment. Cisplatin 95-104 clock circadian regulator Homo sapiens 35-40 29892224-11 2018 Analysis of circadian clock machinery revealed that melatonin or SR9009 exposure upregulated BMAL1, CLOCK, PER2, CRY1, and RORalpha expression, with a higher effect of combined treatment. Melatonin 52-61 clock circadian regulator Homo sapiens 100-105 29534992-6 2018 KEY FINDINGS: The present study shows that KS15 inhibits the interaction between CRYs and Brain-Muscle-Arnt-Like protein 1 (BMAL1), thereby impairing the feedback actions of CRYs on E-box-dependent transcription by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. KS15 43-47 clock circadian regulator Homo sapiens 215-226 29534992-6 2018 KEY FINDINGS: The present study shows that KS15 inhibits the interaction between CRYs and Brain-Muscle-Arnt-Like protein 1 (BMAL1), thereby impairing the feedback actions of CRYs on E-box-dependent transcription by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. KS15 43-47 clock circadian regulator Homo sapiens 310-315 29658882-6 2018 Moreover, basal and insulin-stimulated glucose uptake were significantly reduced upon CLOCK depletion. Glucose 39-46 clock circadian regulator Homo sapiens 86-91 28960346-12 2017 RESULTS: Alcohol increased oxidative stress, caused Caco-2 cell monolayer dysfunction, and increased levels of the circadian clock proteins PER2 and CLOCK. Alcohols 9-16 clock circadian regulator Homo sapiens 125-130 30210566-6 2018 Interestingly Sirtinol, Sirt1 and Sirt2 inhibitors had the greatest significant effect on the expression of clock genes, and increased Hes5 and Tubb3 expression during neuronal differentiation. sirtinol 14-22 clock circadian regulator Homo sapiens 108-113 29587340-7 2018 Antipsychotic-induced restless legs syndrome was linked to polymorphisms located on CLOCK, BTBD9, GNB3, and TH genes, clozapine-induced somnolence was correlated with polymorphisms of HNMT gene, while insomnia was associated with variants of the MTNR1 gene. Clozapine 118-127 clock circadian regulator Homo sapiens 84-89 28960346-12 2017 RESULTS: Alcohol increased oxidative stress, caused Caco-2 cell monolayer dysfunction, and increased levels of the circadian clock proteins PER2 and CLOCK. Alcohols 9-16 clock circadian regulator Homo sapiens 149-154 28985504-4 2017 Here, we show that arginine biosynthesis and subsequent ureagenesis are collectively regulated by CLOCK (circadian locomotor output cycles kaput) in circadian rhythms. Arginine 19-27 clock circadian regulator Homo sapiens 98-103 28830875-1 2017 OBJECTIVE: The circadian clock regulates glucose metabolism by mediating the activity of metabolic enzymes, hormones, and transport systems. Glucose 41-48 clock circadian regulator Homo sapiens 25-30 28985504-4 2017 Here, we show that arginine biosynthesis and subsequent ureagenesis are collectively regulated by CLOCK (circadian locomotor output cycles kaput) in circadian rhythms. Arginine 19-27 clock circadian regulator Homo sapiens 105-144 28985504-5 2017 Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis. Arginine 198-206 clock circadian regulator Homo sapiens 59-64 28928877-3 2017 Using the quantitative methodology of pyrosequencing, epigenetic changes in 5-methyl cytosine (5mC) in five circadian genes CLOCK, BMAL1, CRY1, PER1 and PER2 in female nurses working night shift work (278 breast cancer cases, 280 controls) were analyzed. 5-Methylcytosine 76-93 clock circadian regulator Homo sapiens 124-129 28928877-3 2017 Using the quantitative methodology of pyrosequencing, epigenetic changes in 5-methyl cytosine (5mC) in five circadian genes CLOCK, BMAL1, CRY1, PER1 and PER2 in female nurses working night shift work (278 breast cancer cases, 280 controls) were analyzed. 5-Methylcytosine 95-98 clock circadian regulator Homo sapiens 124-129 28928952-5 2017 To demonstrate the sensitivity and versatility of this assay, we show that enzymatic removal of phosphate groups from proteins in tissue extracts or pharmacological inhibition of casein kinase I in cell culture increased CLOCK-BMAL1 DNA binding activity by ~1.5 to ~2 fold, as measured by the CPDBA. Phosphates 96-105 clock circadian regulator Homo sapiens 221-232 28944015-0 2017 Signatures of selection in mammalian clock genes with coding trinucleotide repeats: Implications for studying the genomics of high-pace adaptation. trinucleotide 61-74 clock circadian regulator Homo sapiens 37-42 28944015-8 2017 These preliminary signatures of selection and the presence of trinucleotide repeats within many clock genes warrant further consideration of the importance of candidate gene motifs for adaptation to climate change. trinucleotide 62-75 clock circadian regulator Homo sapiens 96-101 28928952-5 2017 To demonstrate the sensitivity and versatility of this assay, we show that enzymatic removal of phosphate groups from proteins in tissue extracts or pharmacological inhibition of casein kinase I in cell culture increased CLOCK-BMAL1 DNA binding activity by ~1.5 to ~2 fold, as measured by the CPDBA. cpdba 293-298 clock circadian regulator Homo sapiens 221-232 28928952-6 2017 In addition, we show that the CPDBA can measure CLOCK-BMAL1 binding to reconstituted chromatin. cpdba 30-35 clock circadian regulator Homo sapiens 48-59 28928952-7 2017 The CPDBA is a sensitive, fast, efficient and versatile probe of clock function. cpdba 4-9 clock circadian regulator Homo sapiens 65-70 28143926-4 2017 Here we show that CRY1 binds directly to the PAS domain core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS-B domain. Protactinium 45-48 clock circadian regulator Homo sapiens 64-75 28645331-2 2017 The CLOCK (circadian locomotor output cycles protein kaput) gene encodes a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeostasis. Glucose 184-191 clock circadian regulator Homo sapiens 4-9 28645331-2 2017 The CLOCK (circadian locomotor output cycles protein kaput) gene encodes a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeostasis. Glucose 184-191 clock circadian regulator Homo sapiens 128-133 28645331-6 2017 Genetic analyses were conducted with PLINK RESULTS: We found a significant association between the CLOCK SNP rs2070062 and sleep duration, participants carriers of the T allele showed significantly shorter sleep duration compared to non-carriers after the adjustment for individual proportions of European ancestry (PEA), socio economic status (SES), body mass index (BMI), alcohol consumption and smoking status that reach the significance threshold after multiple testing correction. Alcohols 374-381 clock circadian regulator Homo sapiens 99-104 28514207-5 2017 In comparison with the untransfected control group showed the percentage of apoptotic cells in SKOV3/DDP cell lines of Clock interfering expression group after cisplatin treatment was significantly increased while the survival was substantially reduced. Cisplatin 160-169 clock circadian regulator Homo sapiens 119-124 28514207-6 2017 These results indicated that inhibiting the circadian gene Clock expression can reverse the cisplatin resistance of ovarian cancer SKOV3/DDP cell lines by affecting the protein expression of drug resistance genes during which autophagy plays an important role. Cisplatin 92-101 clock circadian regulator Homo sapiens 59-64 27670267-0 2017 The CLOCK trial, a double-blinded randomized controlled trial: Trisodium citrate 30% and minocycline 3 mg/mL plus EDTA 30 mg/mL are effective and safe for catheter patency maintenance among CKD 5D patients on hemodialysis. trisodium citrate 63-80 clock circadian regulator Homo sapiens 4-9 27670267-0 2017 The CLOCK trial, a double-blinded randomized controlled trial: Trisodium citrate 30% and minocycline 3 mg/mL plus EDTA 30 mg/mL are effective and safe for catheter patency maintenance among CKD 5D patients on hemodialysis. Minocycline 89-100 clock circadian regulator Homo sapiens 4-9 27670267-0 2017 The CLOCK trial, a double-blinded randomized controlled trial: Trisodium citrate 30% and minocycline 3 mg/mL plus EDTA 30 mg/mL are effective and safe for catheter patency maintenance among CKD 5D patients on hemodialysis. Edetic Acid 114-118 clock circadian regulator Homo sapiens 4-9 27670267-9 2017 DISCUSSION: The CLOCK Trial suggests TSC and M-EDTA may preserve catheter patency better than H. TSC may be a better option due the lack of association with long-term antimicrobial resistance. m-edta 45-51 clock circadian regulator Homo sapiens 16-21 28143926-4 2017 Here we show that CRY1 binds directly to the PAS domain core of CLOCK:BMAL1, driven primarily by interaction with the CLOCK PAS-B domain. Protactinium 45-48 clock circadian regulator Homo sapiens 64-69 27614897-7 2016 After testosterone stimulation, expression of PER2 showed an oscillating pattern, with two peaks occurring at the 24th and 44th hours; expression of CLOCK increased significantly to the peak at the 24th hour, whereas expression of BMAL1 did not change significantly over time in human luteinized granulosa cells. Testosterone 6-18 clock circadian regulator Homo sapiens 149-154 29106308-4 2017 The aim of the present study was to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of PER1, PER2, PER3, BMAL1, CLOCK, CRY1 CRY2 and NPAS2 genes, taking into account rotating night work and chronotype as potential confounders or modifiers. 5-Methylcytosine 132-148 clock circadian regulator Homo sapiens 201-206 28721811-7 2017 Interestingly, the circadian clock system relies upon the regulation of the critical pathways of autophagy, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) as well as proliferative mechanisms that involve the wingless pathway of Wnt/beta-catenin pathway to foster cell survival during injury and block tumor cell growth. Sirolimus 134-143 clock circadian regulator Homo sapiens 29-34 27746588-2 2016 We decided to verify if haloperidol and olanzapine affect expression of CLOCK, BMAL1, PER1 and CRY1 in a human central nervous system cell line model. Haloperidol 24-35 clock circadian regulator Homo sapiens 72-77 27746588-2 2016 We decided to verify if haloperidol and olanzapine affect expression of CLOCK, BMAL1, PER1 and CRY1 in a human central nervous system cell line model. Olanzapine 40-50 clock circadian regulator Homo sapiens 72-77 27746588-8 2016 Conclusions: At certain concentration, haloperidol seems to affect expression of particular clock genes in a human central nervous system cell line model, yet mechanism underlying this phenomenon remains elusive. Haloperidol 39-50 clock circadian regulator Homo sapiens 92-97 27376484-10 2016 Furthermore, the inhibitory effects of CLOCK-BMAL1 on CACNA1C could be abolished by the Akt inhibitor MK2206 or the PDK1 inhibitor GSK2334470. MK 2206 102-108 clock circadian regulator Homo sapiens 39-50 27376484-10 2016 Furthermore, the inhibitory effects of CLOCK-BMAL1 on CACNA1C could be abolished by the Akt inhibitor MK2206 or the PDK1 inhibitor GSK2334470. GSK 2334470 131-141 clock circadian regulator Homo sapiens 39-50 27635233-0 2016 Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease. Dopamine 24-32 clock circadian regulator Homo sapiens 90-95 27373683-0 2016 TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1. Glucose 35-42 clock circadian regulator Homo sapiens 64-69 27373683-8 2016 Moreover, the TFEB/CLOCK/BMAL1 complex is regulated by glucose. Glucose 55-62 clock circadian regulator Homo sapiens 19-24 27635233-6 2016 For example, rhythms in clock gene expression in the dorsal striatum are sensitive to changes in dopamine release, which has potential implications for Parkinson"s disease and drug addiction. Dopamine 97-105 clock circadian regulator Homo sapiens 24-29 27153104-9 2016 The additional PAS domains in the CLOCK and BMAL1 proteins affect insignificantly the interactions of the CLOCK and BMAL1 proteins with the DNA molecule due to the flexible and long loop linkers located at the middle of the PAS and bHLH domains. Protactinium 15-18 clock circadian regulator Homo sapiens 34-39 27153104-9 2016 The additional PAS domains in the CLOCK and BMAL1 proteins affect insignificantly the interactions of the CLOCK and BMAL1 proteins with the DNA molecule due to the flexible and long loop linkers located at the middle of the PAS and bHLH domains. Protactinium 15-18 clock circadian regulator Homo sapiens 106-111 27153104-9 2016 The additional PAS domains in the CLOCK and BMAL1 proteins affect insignificantly the interactions of the CLOCK and BMAL1 proteins with the DNA molecule due to the flexible and long loop linkers located at the middle of the PAS and bHLH domains. Protactinium 224-227 clock circadian regulator Homo sapiens 34-39 27153104-9 2016 The additional PAS domains in the CLOCK and BMAL1 proteins affect insignificantly the interactions of the CLOCK and BMAL1 proteins with the DNA molecule due to the flexible and long loop linkers located at the middle of the PAS and bHLH domains. Protactinium 224-227 clock circadian regulator Homo sapiens 106-111 26662378-5 2016 RESULTS: Circadian clock disruption resulted in a significant decrease in both acute and chronic glucose-stimulated insulin secretion. Glucose 97-104 clock circadian regulator Homo sapiens 19-24 28058089-0 2016 CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species. Reactive Oxygen Species 64-87 clock circadian regulator Homo sapiens 0-5 26739996-4 2016 CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Glucose 103-110 clock circadian regulator Homo sapiens 0-5 28058089-2 2016 Our previous report indicated that CLOCK increased the accumulation of ROS under hypoxic conditions. Reactive Oxygen Species 71-74 clock circadian regulator Homo sapiens 35-40 28058089-6 2016 Interestingly, pretreatment with 3-methyladenine (3-MA) resulted in the attenuation of CLOCK-induced cell autophagy and but did not influence the production of intracellular reactive oxygen species (ROS). 3-methyladenine 33-48 clock circadian regulator Homo sapiens 87-92 28058089-6 2016 Interestingly, pretreatment with 3-methyladenine (3-MA) resulted in the attenuation of CLOCK-induced cell autophagy and but did not influence the production of intracellular reactive oxygen species (ROS). 3-methyladenine 50-54 clock circadian regulator Homo sapiens 87-92 28058089-7 2016 Furthermore, Tiron (4,5-dihydroxy-1,3-benzene disulfonic acid-disodium salt), a ROS scavenger, significantly attenuated CLOCK-induced cell autophagy. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 13-18 clock circadian regulator Homo sapiens 120-125 28058089-7 2016 Furthermore, Tiron (4,5-dihydroxy-1,3-benzene disulfonic acid-disodium salt), a ROS scavenger, significantly attenuated CLOCK-induced cell autophagy. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 20-75 clock circadian regulator Homo sapiens 120-125 28058089-7 2016 Furthermore, Tiron (4,5-dihydroxy-1,3-benzene disulfonic acid-disodium salt), a ROS scavenger, significantly attenuated CLOCK-induced cell autophagy. Reactive Oxygen Species 80-83 clock circadian regulator Homo sapiens 120-125 26168277-2 2015 Clock genes are known to regulate metabolic processes in peripheral tissues, eg, glucose oxidation. Glucose 81-88 clock circadian regulator Homo sapiens 0-5 26726810-0 2016 Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content. Glucose 0-7 clock circadian regulator Homo sapiens 43-48 26387865-3 2015 We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB. rev-erbalpha 118-130 clock circadian regulator Homo sapiens 82-87 26387865-3 2015 We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBalpha to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB. rev-erb 118-125 clock circadian regulator Homo sapiens 82-87 26075729-0 2015 Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes. Palmitates 0-9 clock circadian regulator Homo sapiens 41-46 26629407-2 2015 In view of the potential role of the skeletal muscle clock in the regulation of glucose metabolism, we aimed to characterize circadian rhythms in primary human skeletal myotubes and investigate their roles in myokine secretion. Glucose 80-87 clock circadian regulator Homo sapiens 53-58 26075729-3 2015 Here we presented evidence that the molecular clock is a novel target of palmitate in hepatocytes. Palmitates 73-82 clock circadian regulator Homo sapiens 46-51 26075729-4 2015 Palmitate exposure at low dose inhibits the molecular clock activity and suppresses the cyclic expression of circadian targets including Dbp, Nr1d1 and Per2 in hepatocytes. Palmitates 0-9 clock circadian regulator Homo sapiens 54-59 26075729-7 2015 Furthermore, we showed that SIRT1 activators could reverse the inhibitory action of palmitate on BMAL1-CLOCK interaction and the clock gene expression, whereas inhibitors of NAD synthesis mimic the palmitate effects on the clock function. Palmitates 84-93 clock circadian regulator Homo sapiens 103-108 26075729-7 2015 Furthermore, we showed that SIRT1 activators could reverse the inhibitory action of palmitate on BMAL1-CLOCK interaction and the clock gene expression, whereas inhibitors of NAD synthesis mimic the palmitate effects on the clock function. Palmitates 84-93 clock circadian regulator Homo sapiens 129-134 26075729-7 2015 Furthermore, we showed that SIRT1 activators could reverse the inhibitory action of palmitate on BMAL1-CLOCK interaction and the clock gene expression, whereas inhibitors of NAD synthesis mimic the palmitate effects on the clock function. Palmitates 198-207 clock circadian regulator Homo sapiens 223-228 26075729-8 2015 In summary, our findings demonstrated that palmitate inhibits the clock function by suppressing SIRT1 function in hepatocytes. Palmitates 43-52 clock circadian regulator Homo sapiens 66-71 25527757-2 2015 Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake. Ghrelin 114-121 clock circadian regulator Homo sapiens 43-82 25780812-6 2015 Individuals with larger number of glutamine residues in the poly-Q region of Clock gene migrated significantly later in one or, respectively, two species depending on sex and whether the within-individual mean length or the length of the longer Clock allele was considered. Glutamine 34-43 clock circadian regulator Homo sapiens 77-82 25780812-6 2015 Individuals with larger number of glutamine residues in the poly-Q region of Clock gene migrated significantly later in one or, respectively, two species depending on sex and whether the within-individual mean length or the length of the longer Clock allele was considered. Glutamine 34-43 clock circadian regulator Homo sapiens 245-250 25527757-2 2015 Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake. Ghrelin 114-121 clock circadian regulator Homo sapiens 84-89 26181468-9 2015 Furthermore, elevated serum testosterone and FSH levels were correlated with the three variants of CLOCK gene in idiopathic infertility. Testosterone 28-40 clock circadian regulator Homo sapiens 99-104 26583060-7 2015 RESULTS: Hypoxia induces ROS production via hCLOCK. ros 25-28 clock circadian regulator Homo sapiens 44-50 26583060-11 2015 Overall findings show that hypoxia increases the expression of hCLOCK, which leads to ROS production, which then activates the RhoA and NF-kappaB pathways. ros 86-89 clock circadian regulator Homo sapiens 63-69 26583060-12 2015 CONCLUSION: Our findings suggest that hypoxic states induce vascular oxidative damage and inflammation via hCLOCK-mediated production of ROS, with subsequent activation of the RhoA and NF-kappaB pathways. ros 137-140 clock circadian regulator Homo sapiens 107-113 24894351-3 2014 At the cellular level, genes involved in lipid synthesis and fatty acid oxidation are rhythmically activated and repressed by core clock proteins in a tissue-specific manner. Fatty Acids 61-71 clock circadian regulator Homo sapiens 131-136 25109449-6 2014 Additionally, expression profiles of different clock genes were determined over 24h by real time PCR in synovial fibroblasts (SFs) after a 2h serum shock or TNF-alpha. Deuterium 139-141 clock circadian regulator Homo sapiens 47-52 25309798-0 2014 Effect of Resveratrol, a SIRT1 Activator, on the Interactions of the CLOCK/BMAL1 Complex. Resveratrol 10-21 clock circadian regulator Homo sapiens 69-74 25309798-11 2014 This inhibitory effect was intensified by treatment with resveratrol, indicating a role for SIRT1 and its activator in CLOCK/BMAL1-mediated transcription of clock genes. Resveratrol 57-68 clock circadian regulator Homo sapiens 119-124 25309798-11 2014 This inhibitory effect was intensified by treatment with resveratrol, indicating a role for SIRT1 and its activator in CLOCK/BMAL1-mediated transcription of clock genes. Resveratrol 57-68 clock circadian regulator Homo sapiens 157-162 24510388-0 2014 Circadian rhythm of homocysteine is hCLOCK genotype dependent. Homocysteine 20-32 clock circadian regulator Homo sapiens 36-42 24510388-11 2014 A reduced plasma Hcy in hCLOCK rs1801260 CC genotype individuals were observed in contrast to CT genotype individuals. Homocysteine 17-20 clock circadian regulator Homo sapiens 24-30 24328727-3 2014 The aim of this research was to find out whether habitual consumption of a low-fat diet, compared with a Mediterranean diet enriched with olive oil, modulates the associations between common CLOCK single nucleotide polymorphisms (SNPs) (rs1801260, rs3749474 and rs4580704) and lipid and glucose-related traits among MetS patients. Glucose 287-294 clock circadian regulator Homo sapiens 191-196 24855952-0 2014 Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Disulfides 87-96 clock circadian regulator Homo sapiens 25-30 24328727-9 2014 Our data support the notion that a chronic consumption of a healthy diet may play a contributing role in triggering glucose metabolism by interacting with the rs1801260 SNP at CLOCK gene locus in MetS patients. Glucose 116-123 clock circadian regulator Homo sapiens 176-181 24636202-0 2014 Polymorphism of circadian clock genes and prophylactic lithium response. Lithium 55-62 clock circadian regulator Homo sapiens 26-31 24679394-1 2014 BACKGROUND: Previously, we found correlations between lithium efficacy in bipolar disorder and temperamental dimensions of the TEMPS-A and also genes involved in the regulation of biological rhythms ("clock" genes). Lithium 54-61 clock circadian regulator Homo sapiens 201-206 24339190-9 2014 Variants in the CLOCK gene were significantly associated with the heavy cocaine use, infrequent intravenous injection group, but not with the DSM-IV diagnosis of CD. Cocaine 72-79 clock circadian regulator Homo sapiens 16-21 24277452-0 2014 Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer. Oxaliplatin 74-85 clock circadian regulator Homo sapiens 32-37 23160374-6 2013 Sumoylation of CLOCK occurred at two lysine residues, K67 and K851. Lysine 37-43 clock circadian regulator Homo sapiens 15-20 25462064-11 2014 Taken together our data support a novel Cyp2e1-circadian clock protein mechanism for alcohol-induced gut leakiness that could provide new avenues for therapy of ALD. Alcohols 85-92 clock circadian regulator Homo sapiens 57-62 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 33-36 clock circadian regulator Homo sapiens 20-25 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 33-36 clock circadian regulator Homo sapiens 112-117 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 45-48 clock circadian regulator Homo sapiens 20-25 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 45-48 clock circadian regulator Homo sapiens 112-117 23160374-6 2013 Sumoylation of CLOCK occurred at two lysine residues, K67 and K851. CHEMBL3948237 54-57 clock circadian regulator Homo sapiens 15-20 23160374-6 2013 Sumoylation of CLOCK occurred at two lysine residues, K67 and K851. 1,2,4-Benzenetriamine dihydrochloride 62-66 clock circadian regulator Homo sapiens 15-20 23160374-8 2013 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay conducted with breast cancer cell lines (MCF-7 and T47D) demonstrated that sumoylation of CLOCK stimulated cell growth and increased the proportion of S phase cells in the cell cycle. thiazolyl blue 0-60 clock circadian regulator Homo sapiens 163-168 23160374-8 2013 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay conducted with breast cancer cell lines (MCF-7 and T47D) demonstrated that sumoylation of CLOCK stimulated cell growth and increased the proportion of S phase cells in the cell cycle. monooxyethylene trimethylolpropane tristearate 62-65 clock circadian regulator Homo sapiens 163-168 22906517-7 2013 The fact that chronotherapies, including SDT and sleep phase advance, are dramatically effective suggests that altered clock gene machinery may represent a core pathophysiological defect in a subset of mood disorder patients. 3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 41-44 clock circadian regulator Homo sapiens 119-124 23660503-9 2013 siRNA knockdown of CYP2E1 in Caco-2 cells prevented alcohol-induced hyperpermeability and induction of CLOCK and PER2 proteins. Alcohols 52-59 clock circadian regulator Homo sapiens 103-108 23660503-10 2013 Alcohol-induced and H2O2-induced increases in intestinal cell CLOCK and PER2 were significantly inhibited by treatment with NAC. Alcohols 0-7 clock circadian regulator Homo sapiens 62-67 23660503-10 2013 Alcohol-induced and H2O2-induced increases in intestinal cell CLOCK and PER2 were significantly inhibited by treatment with NAC. Hydrogen Peroxide 20-24 clock circadian regulator Homo sapiens 62-67 23660503-10 2013 Alcohol-induced and H2O2-induced increases in intestinal cell CLOCK and PER2 were significantly inhibited by treatment with NAC. Acetylcysteine 124-127 clock circadian regulator Homo sapiens 62-67 23660503-11 2013 We concluded that our data support a novel role for intestinal CYP2E1 in alcohol-induced intestinal hyperpermeability via a mechanism involving CYP2E1-dependent induction of oxidative stress and upregulation of circadian clock proteins CLOCK and PER2. Alcohols 73-80 clock circadian regulator Homo sapiens 221-226 23660503-11 2013 We concluded that our data support a novel role for intestinal CYP2E1 in alcohol-induced intestinal hyperpermeability via a mechanism involving CYP2E1-dependent induction of oxidative stress and upregulation of circadian clock proteins CLOCK and PER2. Alcohols 73-80 clock circadian regulator Homo sapiens 236-241 23660503-1 2013 We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. Alcohols 19-26 clock circadian regulator Homo sapiens 159-164 23660503-1 2013 We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. Alcohols 19-26 clock circadian regulator Homo sapiens 174-179 23660503-1 2013 We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. Alcohols 231-238 clock circadian regulator Homo sapiens 159-164 23660503-2 2013 We hypothesized that alcohol metabolism by intestinal Cytochrome P450 isoform 2E1 (CYP2E1) could alter circadian gene expression (Clock and Per2), resulting in alcohol-induced hyperpermeability. Alcohols 21-28 clock circadian regulator Homo sapiens 130-135 23660503-2 2013 We hypothesized that alcohol metabolism by intestinal Cytochrome P450 isoform 2E1 (CYP2E1) could alter circadian gene expression (Clock and Per2), resulting in alcohol-induced hyperpermeability. Alcohols 160-167 clock circadian regulator Homo sapiens 130-135 23229515-4 2013 We demonstrate that CLOCK and BMAL1 bHLH domains can be mutually selected, and that hydrogen-bonding networks mediate their E-box recognition. Hydrogen 84-92 clock circadian regulator Homo sapiens 20-25 23598442-4 2013 Melatonin offset at dawn is linked to cAMP accumulation, which directly induces transcription of the clock gene Per1. Melatonin 0-9 clock circadian regulator Homo sapiens 101-106 23598442-4 2013 Melatonin offset at dawn is linked to cAMP accumulation, which directly induces transcription of the clock gene Per1. Cyclic AMP 38-42 clock circadian regulator Homo sapiens 101-106 23598442-5 2013 The rise of melatonin at dusk induces a separate and distinct cohort, including the clock-regulated genes Cry1 and Nampt, but little is known of the up-stream mechanisms involved. Melatonin 12-21 clock circadian regulator Homo sapiens 84-89 23229515-5 2013 We identified a hydrophobic contact between BMAL1 Ile80 and a flanking thymine nucleotide, suggesting that CLOCK-BMAL1 actually reads 7-bp DNA and not the previously believed 6-bp DNA. Thymine Nucleotides 71-89 clock circadian regulator Homo sapiens 107-118 23524621-7 2013 CONCLUSION: Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants. Hydrocortisone 12-20 clock circadian regulator Homo sapiens 91-96 23251369-6 2012 A marked effect of DEX exposure on both positive and negative clock genes expression patterns was observed. Dexamethasone 19-22 clock circadian regulator Homo sapiens 62-67 22310473-11 2012 CONCLUSION: Variants of both SIRT1 and CLOCK have an additive effect on resistance to weight loss that could be related to the chronotype of the subject, higher plasma levels of ghrelin and less adherence to Mediterranean diet patterns. Ghrelin 178-185 clock circadian regulator Homo sapiens 39-44 23003921-8 2012 Interestingly, the percentage of methylation of CLOCK CpGs 1 and 8 showed associations with the intake of monounsaturated and polyunsaturated fatty acids. monounsaturated and polyunsaturated fatty acids 106-153 clock circadian regulator Homo sapiens 48-53 22923437-4 2012 The transcriptome-wide identification of CIRP-bound RNAs by a biotin-streptavidin-based cross-linking and immunoprecipitation (CLIP) procedure revealed several transcripts encoding circadian oscillator proteins, including CLOCK. Biotin 62-68 clock circadian regulator Homo sapiens 222-227 22390238-7 2012 Different patterns of expression between the AM and PM periods were observed, in particular REV-ERBalpha, which was reduced (p < .05) at the PM period in SAT and VAT of both women and men (women: ~53% lower; men: ~78% lower), whereas CLOCK expression was not altered. rev-erbalpha 92-104 clock circadian regulator Homo sapiens 237-242 21386998-0 2011 Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss. Ghrelin 0-7 clock circadian regulator Homo sapiens 66-71 21819971-0 2011 Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. Steroids 46-53 clock circadian regulator Homo sapiens 10-15 21819971-0 2011 Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. Steroids 46-53 clock circadian regulator Homo sapiens 31-36 21819971-3 2011 Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom, whereas Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. Estradiol 153-162 clock circadian regulator Homo sapiens 103-108 21819971-4 2011 Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. Progesterone 70-82 clock circadian regulator Homo sapiens 9-14 21533241-6 2011 In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models. Alcohols 111-118 clock circadian regulator Homo sapiens 30-35 21533241-6 2011 In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single- and multi-locus models. Caffeine 119-127 clock circadian regulator Homo sapiens 30-35 21463335-7 2011 RESULTS: Alcohol, as low as 0.2%, induced time dependent increases in both Caco-2 cell monolayer permeability and in CLOCK and PER2 proteins. Alcohols 9-16 clock circadian regulator Homo sapiens 117-122 21146585-2 2011 We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity. Lysine 201-208 clock circadian regulator Homo sapiens 68-73 21146585-2 2011 We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity. Lysine 201-208 clock circadian regulator Homo sapiens 110-115 21146585-2 2011 We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity. Lysine 201-207 clock circadian regulator Homo sapiens 68-73 21146585-2 2011 We reported that the circadian rhythm-related transcription factor "Clock", a key component of the biological CLOCK with inherent histone acetyltransferase activity, acetylates glucocorticoid receptor lysines within its hinge region--a "lysine cluster" containing a KXKK motif--and represses its transcriptional activity. Lysine 201-207 clock circadian regulator Homo sapiens 110-115 21386998-7 2011 CONCLUSIONS/SIGNIFICANCE: Sleep reduction, changes in ghrelin values, alterations of eating behaviors and evening preference that characterized CLOCK 3111C carriers could be affecting weight loss. Ghrelin 54-61 clock circadian regulator Homo sapiens 144-149 22179986-6 2011 A search for the histone deacetylase (HDAC) that counterbalanced CLOCK activity revealed that SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner. NAD 103-136 clock circadian regulator Homo sapiens 65-70 22179986-6 2011 A search for the histone deacetylase (HDAC) that counterbalanced CLOCK activity revealed that SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner. NAD 138-145 clock circadian regulator Homo sapiens 65-70 21164265-3 2011 We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor. Lysine 280-286 clock circadian regulator Homo sapiens 75-80 21164265-3 2011 We recently reported that the basic helix-loop- helix transcription factor Clock, which is a histone acetyltransferase and a central component of the self-oscillating transcription factor loop that generates circadian rhythms, represses GR transcriptional activity by acetylating lysine residues within the "lysine cluster" located in the hinge region of the receptor. Lysine 308-314 clock circadian regulator Homo sapiens 75-80 21048160-6 2010 A search for the histone deacetylase (HDAC) that counterbalances CLOCK activity revealed that SIRT1, a nicotinamide adenin dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner. nicotinamide adenin dinucleotide 103-135 clock circadian regulator Homo sapiens 65-70 21048160-6 2010 A search for the histone deacetylase (HDAC) that counterbalances CLOCK activity revealed that SIRT1, a nicotinamide adenin dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner. NAD 137-144 clock circadian regulator Homo sapiens 65-70 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 11-19 clock circadian regulator Homo sapiens 46-51 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 11-19 clock circadian regulator Homo sapiens 174-179 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 11-19 clock circadian regulator Homo sapiens 174-179 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 21-23 clock circadian regulator Homo sapiens 46-51 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 21-23 clock circadian regulator Homo sapiens 174-179 20962226-1 2010 A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is suggested by evidence that manipulations of DA receptors can alter the expression of some clock genes outside the suprachiasmatic nucleus (SCN), the master circadian clock. Dopamine 21-23 clock circadian regulator Homo sapiens 174-179 20666392-0 2010 Heme-based sensing by the mammalian circadian protein CLOCK. Heme 0-4 clock circadian regulator Homo sapiens 54-59 20704703-1 2010 BACKGROUND: The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Dopamine 183-191 clock circadian regulator Homo sapiens 16-55 20704703-1 2010 BACKGROUND: The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Dopamine 183-191 clock circadian regulator Homo sapiens 57-62 20666392-4 2010 CLOCK comprises two PAS domains, each with a heme binding site. Protactinium 20-23 clock circadian regulator Homo sapiens 0-5 20666392-4 2010 CLOCK comprises two PAS domains, each with a heme binding site. Heme 45-49 clock circadian regulator Homo sapiens 0-5 20666392-6 2010 We show that CLOCK PAS-A binds iron(III) protoporhyrin IX to form a complex with 1:1 stoichiometry. iron(iii) protoporhyrin ix 31-57 clock circadian regulator Homo sapiens 13-18 20666392-7 2010 Optical absorbance and resonance Raman studies reveal that the heme of ferric CLOCK PAS-A is a six-coordinate, low-spin complex whose resonance Raman signature is insensitive to pH over the range of protein stability. Heme 63-67 clock circadian regulator Homo sapiens 78-83 20666392-8 2010 Ferrous CLOCK PAS-A is a mixture of five-coordinate, high-spin and six-coordinate, low-spin complexes. pas-a 14-19 clock circadian regulator Homo sapiens 8-13 20666392-9 2010 Ferrous CLOCK PAS-A forms complexes with CO and NO. Carbon Monoxide 41-43 clock circadian regulator Homo sapiens 8-13 20666392-10 2010 Ferric CLOCK PAS-A undergoes reductive nitrosylation in the presence of NO to generate a CLOCK PAS-A-NO, which is a five-coordinate {FeNO}(7) complex. pas-a-no 95-103 clock circadian regulator Homo sapiens 7-12 20666392-10 2010 Ferric CLOCK PAS-A undergoes reductive nitrosylation in the presence of NO to generate a CLOCK PAS-A-NO, which is a five-coordinate {FeNO}(7) complex. pas-a-no 95-103 clock circadian regulator Homo sapiens 89-94 20666392-10 2010 Ferric CLOCK PAS-A undergoes reductive nitrosylation in the presence of NO to generate a CLOCK PAS-A-NO, which is a five-coordinate {FeNO}(7) complex. flubendiamide 133-137 clock circadian regulator Homo sapiens 7-12 20666392-10 2010 Ferric CLOCK PAS-A undergoes reductive nitrosylation in the presence of NO to generate a CLOCK PAS-A-NO, which is a five-coordinate {FeNO}(7) complex. flubendiamide 133-137 clock circadian regulator Homo sapiens 89-94 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. pas-a 76-81 clock circadian regulator Homo sapiens 70-75 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. pas-a 76-81 clock circadian regulator Homo sapiens 125-130 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. pas-a 131-136 clock circadian regulator Homo sapiens 70-75 20430893-0 2010 CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. Glycogen 45-53 clock circadian regulator Homo sapiens 0-5 20430893-3 2010 However, no direct evidence has yet implicated the circadian clock in the regulation of glycogen metabolism at the molecular level. Glycogen 88-96 clock circadian regulator Homo sapiens 61-66 20430893-4 2010 We show here that a Clock gene mutation damps the circadian rhythm of the hepatic glycogen content, as well as the circadian mRNA and protein expression of Gys2 (glycogen synthase 2), which is the rate-limiting enzyme of glycogenesis in the liver. Glycogen 82-90 clock circadian regulator Homo sapiens 20-25 20430893-7 2010 Thus, CLOCK regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. Glycogen 55-63 clock circadian regulator Homo sapiens 6-11 20653450-8 2010 A significant interaction between the 5-HTTLPR variant and the haplotype rs1554483-rs4864548 of the CLOCK gene was detected for diastolic (p = .0058) and systolic blood pressure (p = .0014), arterial hypertension (p = .033), plasma triglycerides levels (p = .033), and number of MS components (p = .01). Triglycerides 232-245 clock circadian regulator Homo sapiens 100-105 20404168-5 2010 These results demonstrate that melatonin suppresses the Clock/+ mutant phenotype and interacts with Clock to affect the mammalian circadian system. Melatonin 31-40 clock circadian regulator Homo sapiens 56-61 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. pas-a 131-136 clock circadian regulator Homo sapiens 125-130 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. Heme 184-188 clock circadian regulator Homo sapiens 70-75 20666392-12 2010 Comparison of the spectroscopic properties and CO-binding kinetics of CLOCK PAS-A with other CO sensor proteins reveals that CLOCK PAS-A exhibits chemical properties consistent with a heme-based gas sensor protein. Heme 184-188 clock circadian regulator Homo sapiens 125-130 20560707-2 2010 In particular, a T/C change (rs1801260) at the 3111 position of the circadian locomotor output cycles kaput (CLOCK) gene has been explored in psychiatry disorders. Carbon 19-20 clock circadian regulator Homo sapiens 68-107 20560707-2 2010 In particular, a T/C change (rs1801260) at the 3111 position of the circadian locomotor output cycles kaput (CLOCK) gene has been explored in psychiatry disorders. Carbon 19-20 clock circadian regulator Homo sapiens 109-114 20404168-5 2010 These results demonstrate that melatonin suppresses the Clock/+ mutant phenotype and interacts with Clock to affect the mammalian circadian system. Melatonin 31-40 clock circadian regulator Homo sapiens 100-105 19928495-4 2009 In this paper, we describe ATF4, Clock, ZNF143, and YB-1 as cisplatin resistance genes. Cisplatin 60-69 clock circadian regulator Homo sapiens 33-38 20187847-0 2010 The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents. Alcohols 57-64 clock circadian regulator Homo sapiens 4-9 20187847-2 2010 Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Alcohols 93-100 clock circadian regulator Homo sapiens 74-79 20180986-0 2010 CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. Alcohols 46-53 clock circadian regulator Homo sapiens 0-5 20180986-8 2010 CONCLUSION: Our findings suggest an association between the CLOCK gene and the comorbid condition of alcohol use and depressive disorders. Alcohols 101-108 clock circadian regulator Homo sapiens 60-65 20180986-9 2010 Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. Alcohols 150-157 clock circadian regulator Homo sapiens 53-58 19946213-0 2009 A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation. Serine 2-8 clock circadian regulator Homo sapiens 42-47 19946213-3 2009 We have identified a conserved cluster of serines that include, Ser431, which is a prerequisite phosphorylation site for the generation of BMAL dependent phospho-primed CLOCK and for the potential GSK-3 phosphorylation at Ser427. Serine 42-49 clock circadian regulator Homo sapiens 169-174 19846548-0 2009 CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. Fatty Acids, Monounsaturated 67-94 clock circadian regulator Homo sapiens 0-5 19846548-2 2009 OBJECTIVE: The objective was to study the associations of 5 CLOCK polymorphisms with MetS features by analyzing fatty acid (FA) composition from dietary and red blood cell (RBC) membrane sources. Fatty Acids 112-122 clock circadian regulator Homo sapiens 60-65 19846548-9 2009 The monounsaturated fatty acid (MUFA) content of RBC membranes, particularly oleic acid, changed according to CLOCK genetic variants (P < 0.05). Fatty Acids, Monounsaturated 4-30 clock circadian regulator Homo sapiens 110-115 19846548-9 2009 The monounsaturated fatty acid (MUFA) content of RBC membranes, particularly oleic acid, changed according to CLOCK genetic variants (P < 0.05). Fatty Acids, Monounsaturated 32-36 clock circadian regulator Homo sapiens 110-115 19846548-9 2009 The monounsaturated fatty acid (MUFA) content of RBC membranes, particularly oleic acid, changed according to CLOCK genetic variants (P < 0.05). Oleic Acid 77-87 clock circadian regulator Homo sapiens 110-115 19846548-13 2009 We also found different effects across CLOCK 3111T-->C genotypes for saturated fatty acid intake (% of energy) (P = 0.017). Fatty Acids 72-92 clock circadian regulator Homo sapiens 39-44 20065968-13 2010 CLOCK polymorphisms were also associated with significant differences in total plasma cholesterol at the completion of dietary treatment (P<0.05). Cholesterol 86-97 clock circadian regulator Homo sapiens 0-5 20205566-0 2010 Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. Ethanol 41-48 clock circadian regulator Homo sapiens 94-99 20205566-4 2010 These results suggest mRNA expression of clock genes is associated with obesity, glucose tolerance, and ethanol consumption even in healthy people. Glucose 81-88 clock circadian regulator Homo sapiens 41-46 20205566-4 2010 These results suggest mRNA expression of clock genes is associated with obesity, glucose tolerance, and ethanol consumption even in healthy people. Ethanol 104-111 clock circadian regulator Homo sapiens 41-46 19861640-2 2010 In this study, we investigated whether messenger RNA (mRNA) levels of clock genes are associated with age, body mass index, blood pressures, fasting plasma glucose, or shift work. Glucose 156-163 clock circadian regulator Homo sapiens 70-75 19861640-7 2010 These results suggest that increased age, glucose intolerance, and irregular hours independently affect the intracellular clock in humans. Glucose 42-49 clock circadian regulator Homo sapiens 122-127 20595783-0 2010 Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta). Norepinephrine 0-13 clock circadian regulator Homo sapiens 22-27 20595783-2 2010 To evaluate involvement of noradrenergic systems in regulation of circadian variation of clock-genes in astrocytes, we investigated effects of noradrenaline (NA) on expression of several clock genes in C6 glioma cells by using real-time PCR analysis. Norepinephrine 143-156 clock circadian regulator Homo sapiens 187-192 19928495-5 2009 Clock and the ATF4 transcription system might play an important role in multidrug resistance through the glutathione-dependent redox system, and the physiological potential of the Clock-controlled redox system might be important to better understand oxidative stress-associated disorders including cancer and systemic chronotherapy. Glutathione 105-116 clock circadian regulator Homo sapiens 0-5 18798788-7 2009 Furthermore, mutating MT1 melatonin receptor (i.e., MT1 knockouts, MT1(-/-)) reversed melatonin-induced changes, indicating the involvement of MT1 receptor in the regulatory action of melatonin on neuronal clock gene expression. Melatonin 86-95 clock circadian regulator Homo sapiens 206-211 19141540-0 2009 Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. Lysine 146-152 clock circadian regulator Homo sapiens 38-43 19141540-6 2009 CLOCK and GR interacted with each other physically, and CLOCK suppressed binding of GR to its DNA recognition sequences by acetylating multiple lysine residues located in its hinge region. Lysine 144-150 clock circadian regulator Homo sapiens 0-5 19141540-6 2009 CLOCK and GR interacted with each other physically, and CLOCK suppressed binding of GR to its DNA recognition sequences by acetylating multiple lysine residues located in its hinge region. Lysine 144-150 clock circadian regulator Homo sapiens 56-61 19299583-0 2009 Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. NAD 54-58 clock circadian regulator Homo sapiens 10-15 19299583-2 2009 Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. NAD 63-96 clock circadian regulator Homo sapiens 247-252 19299583-2 2009 Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. NAD 98-102 clock circadian regulator Homo sapiens 247-252 19299583-4 2009 In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1. NAD 131-135 clock circadian regulator Homo sapiens 44-49 18798788-0 2009 The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal "clock" gene expression in striatal neurons in vitro. Melatonin 4-13 clock circadian regulator Homo sapiens 105-110 18798788-2 2009 Clock genes are proposed as regulatory factors in forming dopamine-related behaviors and mood and melatonin has the ability to regulate these processes. Dopamine 58-66 clock circadian regulator Homo sapiens 0-5 18798788-2 2009 Clock genes are proposed as regulatory factors in forming dopamine-related behaviors and mood and melatonin has the ability to regulate these processes. Melatonin 98-107 clock circadian regulator Homo sapiens 0-5 18798788-3 2009 Melatonin-mediated changes in clock gene expression have been reported in brain regions, including the striatum, that are crucial for the development of dopaminergic behaviors and mood. Melatonin 0-9 clock circadian regulator Homo sapiens 30-35 19224106-1 2009 Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Dopamine 108-116 clock circadian regulator Homo sapiens 13-18 18798788-8 2009 Therefore, by controlling clock gene expression we propose melatonin receptors (i.e., MT1) as novel therapeutic targets for the pathobiologies of dopamine-related behaviors and mood. Dopamine 146-154 clock circadian regulator Homo sapiens 26-31 18798788-6 2009 We found that melatonin at the receptor affinity range (i.e., nm) affects the expression of the clock genes mPer1, mClock, mBmal1 and mNPAS2 (neuronal PAS domain protein 2) differentially in a pertussis toxin-sensitive manner: a decrease in Per1 and Clock, an increase in NPAS2 and no change in Bmal1 expression. Melatonin 14-23 clock circadian regulator Homo sapiens 96-101 18798788-6 2009 We found that melatonin at the receptor affinity range (i.e., nm) affects the expression of the clock genes mPer1, mClock, mBmal1 and mNPAS2 (neuronal PAS domain protein 2) differentially in a pertussis toxin-sensitive manner: a decrease in Per1 and Clock, an increase in NPAS2 and no change in Bmal1 expression. Melatonin 14-23 clock circadian regulator Homo sapiens 116-121 18662537-4 2008 (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. NAD 32-38 clock circadian regulator Homo sapiens 130-135 19347611-0 2009 CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients. Fluvoxamine 34-45 clock circadian regulator Homo sapiens 0-5 19347611-3 2009 Therefore, we examined the association between CLOCK and the efficacy of fluvoxamine treatment in 121 patients with Japanese major depressive disorder (MDD). Fluvoxamine 73-84 clock circadian regulator Homo sapiens 47-52 19347611-11 2009 Our results indicate that CLOCK genotype may be a predictor of fluvoxamine treatment response in Japanese MDD. Fluvoxamine 63-74 clock circadian regulator Homo sapiens 26-31 16685415-4 2006 A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2. Arginine 48-51 clock circadian regulator Homo sapiens 132-137 18458078-0 2008 Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. Cisplatin 78-87 clock circadian regulator Homo sapiens 53-58 18458078-11 2008 Our data show that HAT gene expression is required for cisplatin resistance and suggest that Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation. Cisplatin 55-64 clock circadian regulator Homo sapiens 93-98 18433872-6 2008 Synchronization of HCT-116 cells by dexamethasone showed oscillation of hBD-1 and c-myc mRNA indicating that both are clock-controlled output genes. Dexamethasone 36-49 clock circadian regulator Homo sapiens 118-123 17347670-3 2007 Stimulation with serum rapidly induced nuclear translocation, heterodimerization and Ser/Thr phosphorylation of CLOCK just before the surge of Per1 transcription. Serine 85-88 clock circadian regulator Homo sapiens 112-117 17347670-3 2007 Stimulation with serum rapidly induced nuclear translocation, heterodimerization and Ser/Thr phosphorylation of CLOCK just before the surge of Per1 transcription. Threonine 89-92 clock circadian regulator Homo sapiens 112-117 17347670-6 2007 Furthermore, phorbol myristic acetate treatment triggered immediate-early transcription of Per1 and also CLOCK phosphorylation, which were blocked by a Ca2+-dependent PKC inhibitor. phorbol myristic acetate 13-37 clock circadian regulator Homo sapiens 105-110 17097616-1 2006 In the mammalian heart, the circadian protein Clock regulates glucose and fatty acid metabolism. Glucose 62-69 clock circadian regulator Homo sapiens 46-51 17097616-1 2006 In the mammalian heart, the circadian protein Clock regulates glucose and fatty acid metabolism. Fatty Acids 74-84 clock circadian regulator Homo sapiens 46-51 17097616-4 2006 Increasing calcium and cross-bridge cycling with 10 microM phenylephrine for 48 h resulted in a threefold increase in Clock and a translocation of the protein to the nucleus. Calcium 11-18 clock circadian regulator Homo sapiens 118-123 17097616-4 2006 Increasing calcium and cross-bridge cycling with 10 microM phenylephrine for 48 h resulted in a threefold increase in Clock and a translocation of the protein to the nucleus. Phenylephrine 59-72 clock circadian regulator Homo sapiens 118-123 17097616-5 2006 When myofilament cross-bridge cycling was inhibited with 10 microM verapamil or 7.5mM butanedione monoxime for 48 h, both significantly reduced the presence of Clock in the nucleus and cytoskeleton. Verapamil 67-76 clock circadian regulator Homo sapiens 160-165 17097616-5 2006 When myofilament cross-bridge cycling was inhibited with 10 microM verapamil or 7.5mM butanedione monoxime for 48 h, both significantly reduced the presence of Clock in the nucleus and cytoskeleton. diacetylmonoxime 86-106 clock circadian regulator Homo sapiens 160-165 17297441-5 2007 We demonstrate that ATF4 is a direct target of Clock, and that Clock is overexpressed in cisplatin-resistant cells. Cisplatin 89-98 clock circadian regulator Homo sapiens 47-52 17297441-5 2007 We demonstrate that ATF4 is a direct target of Clock, and that Clock is overexpressed in cisplatin-resistant cells. Cisplatin 89-98 clock circadian regulator Homo sapiens 63-68 17297441-6 2007 Furthermore, Clock expression significantly correlates with cisplatin sensitivity, and that the downregulation of either Clock or ATF4 confers sensitivity of A549 cells to cisplatin and etoposide. Cisplatin 60-69 clock circadian regulator Homo sapiens 13-18 17297441-6 2007 Furthermore, Clock expression significantly correlates with cisplatin sensitivity, and that the downregulation of either Clock or ATF4 confers sensitivity of A549 cells to cisplatin and etoposide. Cisplatin 172-181 clock circadian regulator Homo sapiens 121-126 17297441-6 2007 Furthermore, Clock expression significantly correlates with cisplatin sensitivity, and that the downregulation of either Clock or ATF4 confers sensitivity of A549 cells to cisplatin and etoposide. Etoposide 186-195 clock circadian regulator Homo sapiens 121-126 17297441-9 2007 These results suggest that the Clock and ATF4 transcription system might play an important role in multidrug resistance through glutathione-dependent redox system, and also indicate that physiological potentials of Clock-controlled redox system might be important to better understand the oxidative stress-associated disorders including cancer and systemic chronotherapy. Glutathione 128-139 clock circadian regulator Homo sapiens 31-36 17297441-9 2007 These results suggest that the Clock and ATF4 transcription system might play an important role in multidrug resistance through glutathione-dependent redox system, and also indicate that physiological potentials of Clock-controlled redox system might be important to better understand the oxidative stress-associated disorders including cancer and systemic chronotherapy. Glutathione 128-139 clock circadian regulator Homo sapiens 215-220 17469042-4 2007 Using real time RT-PCR with relative quantitation, we investigated whether pioglitazone treatment altered clock gene expression in RNA extracted from peripheral white blood cells (PBCs). Pioglitazone 75-87 clock circadian regulator Homo sapiens 106-111 17116390-7 2007 It is important to explore the association between CLOCK and dopamine function, and to examine the impact of CLOCK on phenotypes such as symptoms and drug response in patients with schizophrenia. Dopamine 61-69 clock circadian regulator Homo sapiens 51-56 16685415-4 2006 A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2. Alanine 56-59 clock circadian regulator Homo sapiens 132-137 16685415-4 2006 A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2. Lysine 63-66 clock circadian regulator Homo sapiens 132-137 16685415-6 2006 These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation. Arginine 36-39 clock circadian regulator Homo sapiens 113-118 15523558-4 2004 Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Glucose 100-107 clock circadian regulator Homo sapiens 26-31 15689397-0 2005 Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Cyclophosphamide 52-68 clock circadian regulator Homo sapiens 109-114 15523558-4 2004 Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Glucose 100-107 clock circadian regulator Homo sapiens 60-65 15523558-4 2004 Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Triglycerides 112-125 clock circadian regulator Homo sapiens 26-31 15523558-4 2004 Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Triglycerides 112-125 clock circadian regulator Homo sapiens 60-65 15346201-7 2004 Furthermore, we injected rat through the common carotid artery with hClock-(35-47)-FITC peptide, and cryostat sections of the brain were prepared and observed using a fluorescence microscope. Fluorescein-5-isothiocyanate 83-87 clock circadian regulator Homo sapiens 68-74 15331141-3 2004 We hypothesized that clozapine might interfere with the circadian rhythms regulated by the biological clock. Clozapine 21-30 clock circadian regulator Homo sapiens 102-107 15331141-9 2004 We conclude that an interaction between clozapine and the CLOCK gene polymorphism 3111 T/C substitution could explain persistent daytime sleepiness in a significant proportion of patients treated with clozapine. Clozapine 40-49 clock circadian regulator Homo sapiens 58-63 15331141-9 2004 We conclude that an interaction between clozapine and the CLOCK gene polymorphism 3111 T/C substitution could explain persistent daytime sleepiness in a significant proportion of patients treated with clozapine. Clozapine 201-210 clock circadian regulator Homo sapiens 58-63 12435807-5 2002 Aurintricarboxylic acid, a ligand inhibitor of IFN-alpha, dose dependently inhibited the IFN-alpha-induced phosphorylation of the signal transducer and activator of transcription 1 (STAT1) protein in HepG2 cells, accompanied by the restoration of Clock and Bmal1 mRNA levels. Aurintricarboxylic Acid 0-23 clock circadian regulator Homo sapiens 247-252 14715703-0 2004 The metabolism of phospholipids oscillates rhythmically in cultures of fibroblasts and is regulated by the clock protein PERIOD 1. Phospholipids 18-31 clock circadian regulator Homo sapiens 107-112 14715703-9 2004 The results demonstrate that the biosynthesis of phospholipids oscillates daily in cultured fibroblasts by an endogenous clock mechanism involving Per1 expression. Phospholipids 49-62 clock circadian regulator Homo sapiens 121-126 11707566-4 2001 The glutamine-rich area of Clock, which is assumed to function in circadian rhythmicity, is expanded in Spalax compared with that of humans and mice, and is different in amino acid composition from that of rats. Glutamine 4-13 clock circadian regulator Homo sapiens 27-32 11707566-6 2001 We suggest that this reduction in transcriptional activity may be attributed to the Spalax Clock glutamine-rich domain, which is unique in its amino acid composition compared with other studied mammalian species. Glutamine 97-106 clock circadian regulator Homo sapiens 91-96 11511917-0 2001 The polyglutamine motif is highly conserved at the Clock locus in various organisms and is not polymorphic in humans. polyglutamine 4-17 clock circadian regulator Homo sapiens 51-56 11027210-0 2000 Light and glutamate-induced degradation of the circadian oscillating protein BMAL1 during the mammalian clock resetting. Glutamic Acid 10-19 clock circadian regulator Homo sapiens 104-109