PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30135866-0 2018 Combinatorial Expression of Grp and Neurod6 Defines Dopamine Neuron Populations with Distinct Projection Patterns and Disease Vulnerability. Dopamine 52-60 neurogenic differentiation 6 Mus musculus 36-43 33979604-6 2021 We demonstrate the utility of this approach by generating DAT-P2A-Flpo;NEX-Cre mice that specifically label Neurod6-expressing dopamine neurons, which project to the nucleus accumbens medial shell. Dopamine 127-135 neurogenic differentiation 6 Mus musculus 108-115 33087478-3 2020 Here, we demonstrate that the base excision repair protein DNA polymerase beta (Polbeta) is involved in hippocampal pyramidal neuron differentiation via a TET-mediated active DNA demethylation during early postnatal stages using Nex-Cre/Polbetafl/fl mice of either sex, in which forebrain postmitotic excitatory neurons lack Polbeta expression. tetramethylenedisulfotetramine 155-158 neurogenic differentiation 6 Mus musculus 229-232 31850343-9 2019 Finally, analysis of markers representing subtypes of dopamine neurons, including the newly described NeuroD6 subtype, shows that certain subtype specifications arise early. Dopamine 54-62 neurogenic differentiation 6 Mus musculus 102-109 32474563-7 2020 In the neuronal apoptosis and regeneration module, Nefh, NeuroD6, and Dcx in the 2-MesADP group were noticed due to their interesting expression pattern. methylthio-ADP 81-89 neurogenic differentiation 6 Mus musculus 57-64 30135866-7 2018 Grp+/Neurod6+ dopamine neurons reside in the ventromedial VTA, send projections to the medial shell of the nucleus accumbens, and have noncanonical physiological properties. Dopamine 14-22 neurogenic differentiation 6 Mus musculus 5-12 30135866-8 2018 Grp+/Neurod6- dopamine neurons are found in the VTA as well as in the ventromedial portion of the SNc, where they project selectively to the dorsomedial striatum. Dopamine 14-22 neurogenic differentiation 6 Mus musculus 5-12 30135866-9 2018 Grp-/Neurod6+ dopamine neurons represent a smaller VTA subpopulation, which is preferentially spared in a 6-OHDA model of Parkinson"s disease. Dopamine 14-22 neurogenic differentiation 6 Mus musculus 5-12 30135866-9 2018 Grp-/Neurod6+ dopamine neurons represent a smaller VTA subpopulation, which is preferentially spared in a 6-OHDA model of Parkinson"s disease. Oxidopamine 106-112 neurogenic differentiation 6 Mus musculus 5-12 21880656-4 2012 When injected with tamoxifen, adult NEX-CreERT2 mice induced reporter gene expression exclusively in projection neurons of the neocortex and hippocampus. Tamoxifen 19-28 neurogenic differentiation 6 Mus musculus 36-39 22466292-5 2012 The expression of microRNA 486 was induced by reactive oxygen species that were produced by inflammatory factors, and reactive oxygen species were accumulated in response to the knockdown of NeuroD6, which enhances the downregulation of glutathione peroxidase 3 and thioredoxin-like 1 after traumatic spinal cord injury. Reactive Oxygen Species 118-141 neurogenic differentiation 6 Mus musculus 191-198 22466292-6 2012 NeuroD6 directly bound to regulatory regions of thioredoxin-like 1 and glutathione peroxidase 3 in motor neurons and activated their expression, which promoted reactive oxygen species scavenging. Reactive Oxygen Species 160-183 neurogenic differentiation 6 Mus musculus 0-7 29803225-9 2018 Indomethacin downregulated genes of the Wnt and Notch signaling pathways and increased neuroD6 expression. Indomethacin 0-12 neurogenic differentiation 6 Mus musculus 87-94