PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
8645996-2	1996	IL-4 suppression, through administration of a rat monoclonal antibody antimurine IL-4 (11B11), in euthymic BALB/c mice during the course of immunization with the DNP-coupled hydroxyethyl starch (TI antigen), inhibited the production of anti-DNP IgG1 antibodies, potentiated the synthesis of IgG2a and had no effect on the other isotypes (IgM, IgG2b and IgG3).	2,4-Dinitrophenol	162-165	immunoglobulin heavy variable V1-9	Mus musculus	291-296
8817827-5	1996	Furthermore, oral immunization with CT and LT induced elevated serum titers of IgG1 followed by IgG2a, IgG2b, IgG3 and IgA, while high antigen-specific IgA and IgG1 responses were found in fecal extracts.	Leu-Thr	43-45	immunoglobulin heavy variable V1-9	Mus musculus	96-101
8920703-8	1996	Liposomal TT preparations, particularly those with encapsulated monophosphoryl lipid A/squalene or squalene alone, consistently elicited higher levels of anti-TT IgG2a and IgG2b than aluminum phosphate adsorbed or soluble TT.	monophosphoryl	64-78	immunoglobulin heavy variable V1-9	Mus musculus	162-167
8920703-8	1996	Liposomal TT preparations, particularly those with encapsulated monophosphoryl lipid A/squalene or squalene alone, consistently elicited higher levels of anti-TT IgG2a and IgG2b than aluminum phosphate adsorbed or soluble TT.	Lipid A	79-86	immunoglobulin heavy variable V1-9	Mus musculus	162-167
7589080-5	1995	Serum antigen-specific IgG1 and IgG2a antibody responses were also primed by subcutaneous immunization with ISCOMS-OVA, confirming the stimulation of both Th1 and Th2 cells in vivo.	iscoms-ova	108-118	immunoglobulin heavy variable V1-9	Mus musculus	32-37
8604226-8	1996	In vivo neutralization of IL-4 induced a significant BPO-specific IgG2a production and a two-fold reduction of IgG1 production in SJL mice while it accelerated production of BPO-specific IgG2a in Balb/c mice.	Benzoyl Peroxide	53-56	immunoglobulin heavy variable V1-9	Mus musculus	66-71
8655289-3	1995	When co-administered with CT, PB attenuated serum IgG1, IgG2a, IgG2b and IgG3 anti-CT responses in a dose-dependent manner and also reduced levels of circulating anti-CT IgA and total serum IgE.	bismuth subsalicylate	30-32	immunoglobulin heavy variable V1-9	Mus musculus	56-61
7585972-5	1995	IgG1, IgG2A, and IgG2B anti-MTg antibody responses were all suppressed by PTg feeding suggesting that tolerance may be induced in both Th1 and Th2 cells.	Teniposide	74-77	immunoglobulin heavy variable V1-9	Mus musculus	6-11
7782931-7	1995	In mice, when given in vivo, the sterol prevents the induction of spontaneous and induced autoimmune diseases and inhibits Th1 induce IgG2a responses.	Sterols	33-39	immunoglobulin heavy variable V1-9	Mus musculus	134-139
8537104-3	1995	In each case the antibodies to SPf66, CT and lipid A demonstrated an IgG2a predominance.	Lipid A	45-52	immunoglobulin heavy variable V1-9	Mus musculus	69-74
8537104-4	1995	Liposomes containing lipid A not only increased the magnitude of the antibody response to liposomal antigens but elicited predominantly IgG2a subclass antibodies as well.	Lipid A	21-28	immunoglobulin heavy variable V1-9	Mus musculus	136-141
8587787-6	1995	When glutaraldehyde fixed parasitized erythrocytes were incubated with immune serum in suspension, specific IgG2a antibodies were detected by fluorescein staining on the membranes of cells infected with mature stages of parasites.	Glutaral	5-19	immunoglobulin heavy variable V1-9	Mus musculus	108-113
8587787-6	1995	When glutaraldehyde fixed parasitized erythrocytes were incubated with immune serum in suspension, specific IgG2a antibodies were detected by fluorescein staining on the membranes of cells infected with mature stages of parasites.	Fluorescein	142-153	immunoglobulin heavy variable V1-9	Mus musculus	108-113
7558173-6	1995	An MTg-specific CD4+ T-cell line also induced MTg-specific B-cell proliferation and was capable of inducing IgG1, IgG2a and IgG2b synthesis in MTg- primed B cells.	(Methylthio)acetic acid	3-6	immunoglobulin heavy variable V1-9	Mus musculus	114-119
7705414-2	1995	CBA/J mice immunized with protein antigens (keyhole limpet hemocyanin, phospholipase A2) adsorbed to aluminum hydroxide (Alum) develop a Th2-like immune response characterized by the production of large amounts of IgG1 as well as some IgE but little IgG2a, IgG2b and IgG3 antibodies.	Aluminum Hydroxide	101-119	immunoglobulin heavy variable V1-9	Mus musculus	250-255
7705414-2	1995	CBA/J mice immunized with protein antigens (keyhole limpet hemocyanin, phospholipase A2) adsorbed to aluminum hydroxide (Alum) develop a Th2-like immune response characterized by the production of large amounts of IgG1 as well as some IgE but little IgG2a, IgG2b and IgG3 antibodies.	Aluminum Hydroxide	121-125	immunoglobulin heavy variable V1-9	Mus musculus	250-255
7505019-17	1993	However, mice treated with CP-96,345 or octreotide (SOM agonist) in vivo produced granulomas that made little or no IgG2a.	CP96	27-32	immunoglobulin heavy variable V1-9	Mus musculus	116-121
7884802-6	1995	All immunised mice, except those immunised with the SDS-I CW fraction from the R strain, showed higher IgG1 than IgG2a antibody responses to S-LPS (IgG1:IgG2a ratio 3.64-7.71).	Sodium Dodecyl Sulfate	52-55	immunoglobulin heavy variable V1-9	Mus musculus	113-118
7884802-6	1995	All immunised mice, except those immunised with the SDS-I CW fraction from the R strain, showed higher IgG1 than IgG2a antibody responses to S-LPS (IgG1:IgG2a ratio 3.64-7.71).	Sodium Dodecyl Sulfate	52-55	immunoglobulin heavy variable V1-9	Mus musculus	153-158
7884802-6	1995	All immunised mice, except those immunised with the SDS-I CW fraction from the R strain, showed higher IgG1 than IgG2a antibody responses to S-LPS (IgG1:IgG2a ratio 3.64-7.71).	s-lps	141-146	immunoglobulin heavy variable V1-9	Mus musculus	113-118
7982975-3	1994	J774 cells were also found to respond to immobilized IgG2a, but not IgG2b, by the increased production of superoxide, H2O2, and TNF-alpha.	Superoxides	106-116	immunoglobulin heavy variable V1-9	Mus musculus	53-58
7982975-3	1994	J774 cells were also found to respond to immobilized IgG2a, but not IgG2b, by the increased production of superoxide, H2O2, and TNF-alpha.	Hydrogen Peroxide	118-122	immunoglobulin heavy variable V1-9	Mus musculus	53-58
7839723-8	1994	Different oil formulations elicited the different IgG subclasses (IgG1, IgG2a, IgG2b, IgG3).	Oils	10-13	immunoglobulin heavy variable V1-9	Mus musculus	72-77
7529796-7	1995	A similar alpha delta-dex-mediated suppression of germ-line gamma 2a RNA and IgG2a secretion in LPS + IFN-gamma-stimulated cultures was observed.	alpha delta-dex	10-25	immunoglobulin heavy variable V1-9	Mus musculus	77-82
7982975-0	1994	The binding of immobilized IgG2a to Fc gamma 2a receptor activates NF-kappa B via reactive oxygen intermediates and tumor necrosis factor-alpha 1.	reactive oxygen intermediates	82-111	immunoglobulin heavy variable V1-9	Mus musculus	27-32
8063421-6	1994	The level of anti-L. pneumophila antibodies in serum increased in both THC-treated and control mice; however, in the THC group IgG1 antibodies which are stimulated by Th2 cells were elevated while Th1-regulated, IgG2a antibodies were depressed.	Dronabinol	117-120	immunoglobulin heavy variable V1-9	Mus musculus	212-217
8406595-1	1993	Against lipid A (the conserved moiety of lipopolysaccharides from Gram-negative bacteria) neutralizing IgM monoclonal antibodies (mAb) 8-2 and 26-20 anti-idiotypic (Ab2) mAb were produced: Ab2 mAb KM-04 (IgG1) against mAb 8-2, and Ab2 mAb PW-1 (IgG2a) and PW-2 (IgG1) against mAb 26-20.	Lipid A	8-15	immunoglobulin heavy variable V1-9	Mus musculus	245-250
8344434-1	1993	Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis.	13c	73-76	immunoglobulin heavy variable V1-9	Mus musculus	12-17
8344434-1	1993	Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc fragments by limited proteolysis.	Histidine	103-106	immunoglobulin heavy variable V1-9	Mus musculus	12-17
8418041-10	1993	The addition of the adjuvant Quil A or L121 to OS-OMP or OMP resulted in the induction of high levels of bactericidal anti-P1.7,16-specific OMP antibodies, as reflected by the presence of substantial amounts of IgG2a and IgG2b antibodies.	Quil A	29-35	immunoglobulin heavy variable V1-9	Mus musculus	211-216
8418041-10	1993	The addition of the adjuvant Quil A or L121 to OS-OMP or OMP resulted in the induction of high levels of bactericidal anti-P1.7,16-specific OMP antibodies, as reflected by the presence of substantial amounts of IgG2a and IgG2b antibodies.	Nafronyl	39-43	immunoglobulin heavy variable V1-9	Mus musculus	211-216
8418041-10	1993	The addition of the adjuvant Quil A or L121 to OS-OMP or OMP resulted in the induction of high levels of bactericidal anti-P1.7,16-specific OMP antibodies, as reflected by the presence of substantial amounts of IgG2a and IgG2b antibodies.	os-omp	47-53	immunoglobulin heavy variable V1-9	Mus musculus	211-216
8418041-10	1993	The addition of the adjuvant Quil A or L121 to OS-OMP or OMP resulted in the induction of high levels of bactericidal anti-P1.7,16-specific OMP antibodies, as reflected by the presence of substantial amounts of IgG2a and IgG2b antibodies.	orotidylic acid	50-53	immunoglobulin heavy variable V1-9	Mus musculus	211-216
1318336-2	1992	We recently reported that PGE2 potentiated the ability of IFN-gamma to augment IgG2a production in both Ag-specific and polyclonal systems via a cAMP-dependent pathway.	Dinoprostone	26-30	immunoglobulin heavy variable V1-9	Mus musculus	79-84
1457190-2	1992	All the adjuvants induced IgG1 antibody, but saponin elicited the highest titers of IgG2a.	Saponins	45-52	immunoglobulin heavy variable V1-9	Mus musculus	84-89
1318336-2	1992	We recently reported that PGE2 potentiated the ability of IFN-gamma to augment IgG2a production in both Ag-specific and polyclonal systems via a cAMP-dependent pathway.	Cyclic AMP	145-149	immunoglobulin heavy variable V1-9	Mus musculus	79-84
1318336-3	1992	Because antibodies (Ab) directed against class II MHC molecules have been shown to induce a rise in B cell cAMP, we hypothesized that this event, like PGE2 treatment, would promote the production of IgG2a.	Cyclic AMP	107-111	immunoglobulin heavy variable V1-9	Mus musculus	199-204
1318336-3	1992	Because antibodies (Ab) directed against class II MHC molecules have been shown to induce a rise in B cell cAMP, we hypothesized that this event, like PGE2 treatment, would promote the production of IgG2a.	Dinoprostone	151-155	immunoglobulin heavy variable V1-9	Mus musculus	199-204
1318336-5	1992	Moreover, the combined treatment of B lymphocytes with IFN-gamma and PGE2 followed by anti-Ia and LPS resulted in a fourfold rise in IgG2a levels compared with IFN-gamma and LPS.	Dinoprostone	69-73	immunoglobulin heavy variable V1-9	Mus musculus	133-138
1318336-9	1992	Finally, RpcAMP, a cAMP antagonist that blocks cAMP from activating protein kinase A, prevented the increased production of IgG2a induced by anti-Ia Ab.	Cyclic AMP	11-15	immunoglobulin heavy variable V1-9	Mus musculus	124-129
1318336-9	1992	Finally, RpcAMP, a cAMP antagonist that blocks cAMP from activating protein kinase A, prevented the increased production of IgG2a induced by anti-Ia Ab.	Cyclic AMP	19-23	immunoglobulin heavy variable V1-9	Mus musculus	124-129
1318336-10	1992	These results support the theory that a cAMP pathway exists that promotes B cell IgG2a production.	Cyclic AMP	40-44	immunoglobulin heavy variable V1-9	Mus musculus	81-86
1318336-11	1992	Within this pathway, IFN-gamma sensitizes B lymphocytes to cAMP elevators such as anti-class II Ab, and in conjunction with LPS, causes an increase in the frequency of IgG2a-secreting cells and the amount of IgG2a produced.	Cyclic AMP	59-63	immunoglobulin heavy variable V1-9	Mus musculus	168-173
1318336-11	1992	Within this pathway, IFN-gamma sensitizes B lymphocytes to cAMP elevators such as anti-class II Ab, and in conjunction with LPS, causes an increase in the frequency of IgG2a-secreting cells and the amount of IgG2a produced.	Cyclic AMP	59-63	immunoglobulin heavy variable V1-9	Mus musculus	208-213
1371192-2	1992	It is demonstrated that the binding of IgG2a and IgG2b but not IgG1 and IgG3 augments the biosynthesis of C3 both in the presence and in the absence of the phorbol ester, phorbol myristate acetate in the case of both cell types.	Phorbol Esters	156-169	immunoglobulin heavy variable V1-9	Mus musculus	39-44
1592432-5	1992	Analysis of the anti-BSA IgG subclasses induced by NISV and FCA showed that NISV were generally better stimulators of IgG2a than was FCA, but poorer stimulators of IgG1.	nisv	76-80	immunoglobulin heavy variable V1-9	Mus musculus	118-123
1515473-1	1992	A rat IgG2a monoclonal antibody (mAb3A33) directed against the mouse Mac-1 antigen was conjugated with muramyl dipeptide (MDP) by using an intermediate polymer; under such conditions 75 MDP molecules were bound to one antibody molecule.	Acetylmuramyl-Alanyl-Isoglutamine	103-120	immunoglobulin heavy variable V1-9	Mus musculus	6-11
1515473-1	1992	A rat IgG2a monoclonal antibody (mAb3A33) directed against the mouse Mac-1 antigen was conjugated with muramyl dipeptide (MDP) by using an intermediate polymer; under such conditions 75 MDP molecules were bound to one antibody molecule.	Acetylmuramyl-Alanyl-Isoglutamine	122-125	immunoglobulin heavy variable V1-9	Mus musculus	6-11
1371192-2	1992	It is demonstrated that the binding of IgG2a and IgG2b but not IgG1 and IgG3 augments the biosynthesis of C3 both in the presence and in the absence of the phorbol ester, phorbol myristate acetate in the case of both cell types.	Tetradecanoylphorbol Acetate	171-196	immunoglobulin heavy variable V1-9	Mus musculus	39-44
1678774-4	1991	The effector T cells provided excellent helper activity for in vitro antibody responses of 4-hydroxy-5-iodo-nitrophenyl acetic acid-primed B cells with the production principally of the immunoglobulin G1 (IgG1) and IgM isotypes, small quantities of IgG3, and no detectable IgG2a, or IgG2b.	4-hydroxy-5-iodo-nitrophenyl acetic acid	91-131	immunoglobulin heavy variable V1-9	Mus musculus	273-278
1717165-1	1991	We previously reported that administration of high Mr glutaraldehyde-polymerized ovalbumin (OA-POL) 10 days prior to OA Al(OH)3 immunization results in 85 to 99% inhibition of primary and secondary anti-OA IgE responses and 10(2)- to 10(4)-fold increases in OA-specific IgG2a production in each of 14 inbred and 1 outbred murine strains tested.	Glutaral	54-68	immunoglobulin heavy variable V1-9	Mus musculus	270-275
1812932-7	1991	The pattern of antibody-isotypes induced by DDA and CFA was different from the pattern induced by the inactivated virus or by the virus mixed with Al: DDA and CFA induced low amounts of IgG1 antibodies and relatively higher amounts of IgG2a and IgG2b antibodies while the inactivated virus and the mixture of the virus with Al induced higher proportions of IgG1 antibodies.	dimethyldioctadecylammonium	151-154	immunoglobulin heavy variable V1-9	Mus musculus	235-240
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly I	23-40	immunoglobulin heavy variable V1-9	Mus musculus	197-202
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	41-59	immunoglobulin heavy variable V1-9	Mus musculus	197-202
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	61-69	immunoglobulin heavy variable V1-9	Mus musculus	197-202
1717560-2	1991	Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis.	Glutaral	54-68	immunoglobulin heavy variable V1-9	Mus musculus	129-134
1717560-4	1991	glutaraldehyde-polymerized OVA (termed OVA-POL) before OVA-[A1(OH)3] immunization of C57BL/6 mice markedly impairs their capacity to generate OVA-specific IgE responses, while simultaneously resulting in striking enhancement of Ag-specific IgG2a responses.	Glutaral	0-14	immunoglobulin heavy variable V1-9	Mus musculus	240-245
1651969-10	1991	In contrast, the inhibition caused by monomeric IgG2a, which binds to Fc gamma RI most likely on keratinocytes, or monomeric IgG3, which probably binds to this same Fc gamma RI, is abrogated by staurosporine, an inhibitor of protein kinase C, as well as by W7, a calmodulin antagonist.	Staurosporine	194-207	immunoglobulin heavy variable V1-9	Mus musculus	48-53
1582706-1	1992	We reported previously that CBA mice pretreated with dinitrophenyl-Bordetella pertussis (DNP-BP) conjugates exhibited sharply decreased anti-DNP IgE, and increased IgG2a antibodies following immunization with DNP-ovalbumin (DNP-OA) in alum.	dnp-bp	89-95	immunoglobulin heavy variable V1-9	Mus musculus	164-169
1340505-7	1992	While the chemicals provoked IgG anti-hapten antibody responses of equivalent magnitude, only TMA induced an IgE response, and DNCB caused a significantly stronger IgG2a response.	Dinitrochlorobenzene	127-131	immunoglobulin heavy variable V1-9	Mus musculus	164-169
1872014-5	1991	SAF increased the formation of IgG2a antibodies in mice except in the B10.M strain; antibodies of this isotype activate complement and act synergistically with antibody-dependent effector cells more efficiently than antibodies of other isotypes.	Syntex adjuvant formulation	0-3	immunoglobulin heavy variable V1-9	Mus musculus	31-36
1714474-6	1991	Alpha delta-dex is selective in its failure to costimulate IgE production in that IFN-gamma-containing T cell supernatant (Th1 SN) and transforming growth factor-beta-supplemented Th2 SN selectively stimulate a large IgG2a and IgA secretory response, respectively.	alpha delta-dex	0-15	immunoglobulin heavy variable V1-9	Mus musculus	217-222
1717367-0	1991	Long-lived reciprocal regulation of antigen-specific IgE and IgG2a responses in mice treated with glutaraldehyde-polymerized ovalbumin.	Glutaral	98-112	immunoglobulin heavy variable V1-9	Mus musculus	61-66
1710602-0	1991	Antigen-specific modulation of murine IgE and IgG2a responses with glutaraldehyde-polymerized allergen is independent of MHC haplotype and Igh allotype.	Glutaral	67-81	immunoglobulin heavy variable V1-9	Mus musculus	46-51
1754068-3	1991	Clones were selected which secrete IgG2a(k) antibodies highly specific for conjugated N-acetyl-aspartate.	N-acetylaspartate	86-104	immunoglobulin heavy variable V1-9	Mus musculus	35-40
1703203-5	1991	Glutaraldehyde-polymerized ovalbumin (OA-POL)-induced changes in IgE and IgG2a responses are abrogated by in vivo treatment with purified monoclonal anti-IFN-gamma antibody (XMG 1.2), a finding indicative of preferential IFN-gamma production upon exposure to chemically modified, but not native, allergen.	Glutaral	0-14	immunoglobulin heavy variable V1-9	Mus musculus	73-78
1672546-7	1991	The increased anti-MTg autoantibody responses in recipients of cells cultured with MTg and anti-IL-2R mAbs were not restricted to a particular immunoglobulin G (IgG) subclass and included antibody of the IgG1, IgG2A, and IgG2B subclasses.	(Methylthio)acetic acid	19-22	immunoglobulin heavy variable V1-9	Mus musculus	210-215
1659605-1	1991	T560 is IgG2a kappa +, Ia+, B220+, J11d+, Thy-1-, CD3-, CD4-, CD5-, Mac 1-, Mac 2-, nonspecific esterase negative and binds bromelain-treated mouse RBC but not SRBC or ORBC.	srbc	160-164	immunoglobulin heavy variable V1-9	Mus musculus	8-13
2242757-7	1990	The sugar abnormality was most marked in the IgG2a/IgG3 fraction from protein A IgG subclass chromatography.	Sugars	4-9	immunoglobulin heavy variable V1-9	Mus musculus	45-50
2177147-8	1990	A similar effect was observed in Balb/c mice contact sensitized with oxazolone: passive administration of RF-like antibodies resulted in reduced IgG2a response to oxazolone while the level of antibodies belonging to other isotypes was not influenced.	Oxazolone	69-78	immunoglobulin heavy variable V1-9	Mus musculus	145-150
2177147-8	1990	A similar effect was observed in Balb/c mice contact sensitized with oxazolone: passive administration of RF-like antibodies resulted in reduced IgG2a response to oxazolone while the level of antibodies belonging to other isotypes was not influenced.	Oxazolone	163-172	immunoglobulin heavy variable V1-9	Mus musculus	145-150
34836793-8	2022	Moreover, Sufacen  administration was associated with a marked inhibition of the serum specific IgE burst upon allergen exposure, as well as, IgG2a antibody increase, suggesting potential anti-allergy effects with inclination towards Th1.	sufacen	10-17	immunoglobulin heavy variable V1-9	Mus musculus	142-147
2297728-1	1990	A site-specific labeling method was developed in which sulfhydryl groups of a murine IgG2a anti-ovarian monoclonal antibody, 5G6.4, were biotinylated with N-iodoacetyl-N"-biotinylhexylenediamine (Compound 1) following partial reduction of disulfide bonds with dithiothreitol.	Disulfides	239-248	immunoglobulin heavy variable V1-9	Mus musculus	85-90
2297728-1	1990	A site-specific labeling method was developed in which sulfhydryl groups of a murine IgG2a anti-ovarian monoclonal antibody, 5G6.4, were biotinylated with N-iodoacetyl-N"-biotinylhexylenediamine (Compound 1) following partial reduction of disulfide bonds with dithiothreitol.	Dithiothreitol	260-274	immunoglobulin heavy variable V1-9	Mus musculus	85-90
2156880-3	1990	Biotin and avidin were used to attach anti-immunoglobulin isotype antibodies to polystyrene particles by the separate incubation of biotinylated goat anti-mouse isotypes (IgG1-, IgG2a-, IgG2b-, IgG3-, or IgM-specific) with avidin coupled polystyrene particles.	Biotin	0-6	immunoglobulin heavy variable V1-9	Mus musculus	178-183
2156880-3	1990	Biotin and avidin were used to attach anti-immunoglobulin isotype antibodies to polystyrene particles by the separate incubation of biotinylated goat anti-mouse isotypes (IgG1-, IgG2a-, IgG2b-, IgG3-, or IgM-specific) with avidin coupled polystyrene particles.	Polystyrenes	80-91	immunoglobulin heavy variable V1-9	Mus musculus	178-183
31857968-6	2019	Results: The mice group that received propranolol adjuvant and 20 microg of r SAG-1 antigen per dose of injection showed significantly more IFN-gamma production, more proliferation of splenic lymphocytes and higher anti-TLA-specific IgG2a production (three main indexes for cell mediated immunity) in comparison with other groups.	Propranolol	38-49	immunoglobulin heavy variable V1-9	Mus musculus	233-238
2319120-4	1990	By fusing spleen lymphocytes obtained from BALB/c mice pre-immunized with NAAG covalently linked to bovine serum albumin by carbodiimide with SP2/0-Ag 14 mouse myeloma cells, we produced three IgG2a (kappa) MAb which specifically reacted with NAAG.	isospaglumic acid	74-78	immunoglobulin heavy variable V1-9	Mus musculus	193-198
2297728-1	1990	A site-specific labeling method was developed in which sulfhydryl groups of a murine IgG2a anti-ovarian monoclonal antibody, 5G6.4, were biotinylated with N-iodoacetyl-N"-biotinylhexylenediamine (Compound 1) following partial reduction of disulfide bonds with dithiothreitol.	N-iodoacetyl-N'-biotinylhexylenediamine	155-194	immunoglobulin heavy variable V1-9	Mus musculus	85-90
2076177-4	1990	Plasma IgG2a elevation after LDV infection was greatly delayed and reduced by depletion of the mice of CD4+, but not of CD8+, T cells by administration of protein-G-purified anti-CD4 or anti-CD8 mAbs, and completely inhibited by repeated treatment of the mice with cyclophosphamide.	Cyclophosphamide	265-281	immunoglobulin heavy variable V1-9	Mus musculus	7-12
34968460-8	2022	Results showed that animals treated with Flau-A or Flau-A/Mic produced significantly higher levels of antileishmanial IFN-gamma, IL-12, TNF-alpha, GM-CSF, nitrite and IgG2a isotype antibody, when compared to data found in the control (saline and B/Mic) groups; which showed significantly higher levels of parasite-specific IL-4, IL-10 and IgG1 antibody.	flau-a	41-47	immunoglobulin heavy variable V1-9	Mus musculus	167-172
34968460-8	2022	Results showed that animals treated with Flau-A or Flau-A/Mic produced significantly higher levels of antileishmanial IFN-gamma, IL-12, TNF-alpha, GM-CSF, nitrite and IgG2a isotype antibody, when compared to data found in the control (saline and B/Mic) groups; which showed significantly higher levels of parasite-specific IL-4, IL-10 and IgG1 antibody.	flau-a	51-57	immunoglobulin heavy variable V1-9	Mus musculus	167-172
34977257-10	2021	The immunization regimen with two doses showed high IFN-gamma and IgG2a titers in challenged mice with either IVD-P or LT-P EVs.	ivd-p	110-115	immunoglobulin heavy variable V1-9	Mus musculus	66-71
34931614-9	2021	The maximum ratio of IFN-gamma/IL-4 (50.13) and IgG2a/IgG1 (2.65), was induced in mice receivedadvax-formulated PfMSP-142.	pfmsp-142	112-121	immunoglobulin heavy variable V1-9	Mus musculus	48-53
34992603-11	2021	The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues.	th2	87-90	immunoglobulin heavy variable V1-9	Mus musculus	191-196
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	9-18	immunoglobulin heavy variable V1-9	Mus musculus	99-104
34931614-10	2021	Besides, poly(I:C)/advax formulated PfMSP-142 induced a higher ratio of IFN-gamma/IL-4 (25.33) and IgG2a/IgG1 (1.89) when compared with poly(I:C) alone.	Poly I-C	136-145	immunoglobulin heavy variable V1-9	Mus musculus	99-104
34741083-8	2021	Dex 1 mg/kg, EM 7.5 or 75 mg/kg treatments significantly inhibited serum IgE and IgG2a in CRS mice.	Dexamethasone	0-3	immunoglobulin heavy variable V1-9	Mus musculus	81-86
34868027-7	2021	Remarkably, EGCG induced immunoglobulin isotype switching from IgG1 to IgG2a (approximately >64-700 fold increase), exerting a more balanced TH1/TH2 response compared to alum.	epigallocatechin gallate	12-16	immunoglobulin heavy variable V1-9	Mus musculus	71-76
34868027-8	2021	The upregulation of IgG2a correlated with significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) function (approximately 14 fold increase), providing a potent effector-mediated protection in addition to NT and HI.	nt	223-225	immunoglobulin heavy variable V1-9	Mus musculus	20-25
34741083-8	2021	Dex 1 mg/kg, EM 7.5 or 75 mg/kg treatments significantly inhibited serum IgE and IgG2a in CRS mice.	Erythromycin	13-15	immunoglobulin heavy variable V1-9	Mus musculus	81-86
34187350-4	2021	IgG1 and IgG2a levels in fetal brains from BTBR dams exposed to Pb (BTBR-Pb) were significantly higher than those of BTBR-controls (BTBR-C).	Lead	64-66	immunoglobulin heavy variable V1-9	Mus musculus	9-14
34543643-6	2021	The resultant murine IgG2a monoclonal antibody was secreted in, and purified from, mammalian cell culture (5 mg) and demonstrated to be highly specific for TAFC detection by competitive ELISA (detection limit: 15 nM) and in a lateral flow test system (detection limit: 3 ng), using gold nanoparticle conjugated- DAFC-bovine serum albumin for competition.	dafc	312-316	immunoglobulin heavy variable V1-9	Mus musculus	21-26
34187350-4	2021	IgG1 and IgG2a levels in fetal brains from BTBR dams exposed to Pb (BTBR-Pb) were significantly higher than those of BTBR-controls (BTBR-C).	btbr	68-72	immunoglobulin heavy variable V1-9	Mus musculus	9-14
34187350-4	2021	IgG1 and IgG2a levels in fetal brains from BTBR dams exposed to Pb (BTBR-Pb) were significantly higher than those of BTBR-controls (BTBR-C).	Lead	73-75	immunoglobulin heavy variable V1-9	Mus musculus	9-14
34339771-6	2021	Formalin inactivated unadjuvanted vaccine elicited a balanced IgG1 type and IgG2a type antibody indicating a more balanced Th2/Th1 type immune response while alum formulated formalin inactivated antigen elicited significantly high IgG1 antibody in immunized sera and Th2 cytokines in mice splenocytes denoting Th2 type T cell immune response.	Formaldehyde	0-8	immunoglobulin heavy variable V1-9	Mus musculus	76-81
34364252-6	2021	Analysis of ovalbumin-specific IgG, IgG1, and IgG2a antibody titers showed the best results when the particle size of the polyacrylate/nanoemulsion composites is 55 nm, the polyacrylate content is 0.5 wt%, and the nanoemulsion contents is 20 wt%.	carbopol 940	122-134	immunoglobulin heavy variable V1-9	Mus musculus	46-51
34364252-7	2021	Meanwhile, titer analysis also showed that the polyacrylate obviously enhanced the IgG2a titer in mice.	carbopol 940	47-59	immunoglobulin heavy variable V1-9	Mus musculus	83-88
34390765-8	2021	The mutant or wild type CPAF immunization induced not only robust splenic IFN-gamma and serum IgG2a but also sIgA secretion in the vaginal fluids.	1-O-hexadecyl-2-N-methylcarbamol -sn-glycerol-3-phosphocholine	24-28	immunoglobulin heavy variable V1-9	Mus musculus	94-99
34868705-4	2021	The group of GABA and GIN mixture significantly reduced IgE level and dramatically increased OVA-IgG2a antibody production.	gamma-Aminobutyric Acid	13-17	immunoglobulin heavy variable V1-9	Mus musculus	97-102
34868705-4	2021	The group of GABA and GIN mixture significantly reduced IgE level and dramatically increased OVA-IgG2a antibody production.	2-{[(6-Oxo-1,6-Dihydropyridin-3-Yl)methyl]amino}-N-[4-Propyl-3-(Trifluoromethyl)phenyl]benzamide	22-25	immunoglobulin heavy variable V1-9	Mus musculus	97-102
34279352-5	2021	In vivo, MAN-CS-OVA-PLGA-MPs significantly increased the ratio of CD3+CD4+/CD3+CD8+ T cells, increased CD80+, CD86+, and MHC II expression in DCs, and improved OVA-specific IgG, IgG1, IgG2a, and IgG2b antibodies.	man-cs	9-15	immunoglobulin heavy variable V1-9	Mus musculus	184-189
34347892-7	2021	Also, the polarization of mice immune status to protective Th1 response evidenced by increased delayed-type hypersensitivity response and levels of IgG2a, reactive oxygen species and nitric oxide.	2-(beta-D-glucosyl)benzothiazole	59-62	immunoglobulin heavy variable V1-9	Mus musculus	148-153
34153674-10	2021	Serum myeloperoxidase, IgG2a, IL-1beta, IL-6, IL-17, and TNF-alpha and spleen CD4+IFN-gamma+IL-17+ T lymphocytes were reduced after PD1 treatment in IMQ-induced psoriasiform mouse models.	Imiquimod	149-152	immunoglobulin heavy variable V1-9	Mus musculus	23-28
34318604-6	2021	Dex also significantly reduced the proportion of germinal centre B cells and decreased serum IgG, IgG2a/b and IgA levels.	Dexamethasone	0-3	immunoglobulin heavy variable V1-9	Mus musculus	98-105
34161815-11	2021	The analysis of IgG2a reactivity to AMA, TRYPO and EPI antigens revealed that at early stages of infection, the genotype-specific reactivity to AMA, TRYPO and EPI to distinguish was higher for TcI/Colombiana as compared to TcII/Y and TcVI/CL while, at late stages of infection, higher reactivity to AMA was observed in mice infected with TcVI/CL and TcII/Y strains.	tcvi	338-342	immunoglobulin heavy variable V1-9	Mus musculus	16-21
35359962-7	2022	Materials/Methods: Anti-mouse-PD-L1 and isotype control antibodies were labelled with indium-111 ((111In)In-DTPA-anti-mPD-L1 and (111In)In-DTPA-IgG2a, respectively).	Pentetic Acid	108-112	immunoglobulin heavy variable V1-9	Mus musculus	144-149
35533760-9	2022	Additionally, in propranolol-treated mice, in accordance with the changes in INF-gamma/IL-4 ratio in dLN cell/splenocyte cultures, serum IgG2a/IgG1 ratio was shifted towards IgG1 reflecting decreased IgG2a response.	Propranolol	17-28	immunoglobulin heavy variable V1-9	Mus musculus	137-142
35533760-9	2022	Additionally, in propranolol-treated mice, in accordance with the changes in INF-gamma/IL-4 ratio in dLN cell/splenocyte cultures, serum IgG2a/IgG1 ratio was shifted towards IgG1 reflecting decreased IgG2a response.	Propranolol	17-28	immunoglobulin heavy variable V1-9	Mus musculus	200-205
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	z-cys	233-238	immunoglobulin heavy variable V1-9	Mus musculus	91-97
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	z-cys	233-238	immunoglobulin heavy variable V1-9	Mus musculus	221-227
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	Cysteine	307-310	immunoglobulin heavy variable V1-9	Mus musculus	91-97
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	Cysteine	307-310	immunoglobulin heavy variable V1-9	Mus musculus	221-227
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	z-cys	314-319	immunoglobulin heavy variable V1-9	Mus musculus	91-97
35428031-3	2022	Surface plasma resonance (SPR) measurement of the binding kinetics of mouse myeloma IgG2a (mIgG2a) to the two ligands indicated that oriented ligand immobilization significantly increased the association rate constant of mIgG2a, and Z-Cys had the highest binding affinity to mIgG2a among the three ligands (Cys-Z, Z-Cys and Z).	z-cys	314-319	immunoglobulin heavy variable V1-9	Mus musculus	221-227
35428031-9	2022	Single-molecule imaging showed that mIgG2a was associated with flexible Z-Cys on the tiles predominantly in side-on and end-on orientations.	z-cys	72-77	immunoglobulin heavy variable V1-9	Mus musculus	36-42
35409371-7	2022	Results showed that menthone inhalation increased serum OVA-specific IgG2a/IgG1 and IgG2a/IgE ratios, increased Th1-type cytokine production in the bronchoalveolar lavage fluid, and decreased nitric oxide, protein, and eotaxin levels.	menthone	20-28	immunoglobulin heavy variable V1-9	Mus musculus	69-74
35409371-7	2022	Results showed that menthone inhalation increased serum OVA-specific IgG2a/IgG1 and IgG2a/IgE ratios, increased Th1-type cytokine production in the bronchoalveolar lavage fluid, and decreased nitric oxide, protein, and eotaxin levels.	menthone	20-28	immunoglobulin heavy variable V1-9	Mus musculus	84-89
35471048-3	2022	The defucosylated mouse IgG2a version of EMab-134 exhibits antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in dEGFR-overexpressed CHO-K1 (CHO/dEGFR) cells and antitumor activities in mouse xenografts of CHO/dEGFR cells.	emab-134	41-49	immunoglobulin heavy variable V1-9	Mus musculus	24-29
2534665-5	1989	The mesangial IC-deposits in mercury-treated SJL mice contained significantly more IgG1, but significantly less IgG2a and C3 than the combined mesangial-capillary loop deposits in MRL mice.	Mercury	29-36	immunoglobulin heavy variable V1-9	Mus musculus	112-117
35070938-3	2022	IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As.	btbr	40-44	immunoglobulin heavy variable V1-9	Mus musculus	5-10
35070938-3	2022	IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As.	Arsenic	61-63	immunoglobulin heavy variable V1-9	Mus musculus	5-10
35070938-3	2022	IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As.	btbr	65-69	immunoglobulin heavy variable V1-9	Mus musculus	5-10
35070938-3	2022	IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As.	Arsenic	70-72	immunoglobulin heavy variable V1-9	Mus musculus	5-10
35070938-3	2022	IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As.	Arsenic	195-197	immunoglobulin heavy variable V1-9	Mus musculus	5-10
2628287-2	1989	Murine monoclonal antibodies 2C10 (IgG2b) and 1A2 (IgG2a), which are known to react specifically with double-stranded (ds) DNA, dissociated completely from their complexes with DNA when washed with a neutral 0.5 M NaCl solution.	nacl solution	214-227	immunoglobulin heavy variable V1-9	Mus musculus	51-56
35095344-5	2022	Pristane injection induced the increase in IgM levels in both wild-type and T cell-deficient TCRalpha -/- mice whereas IgG, IgG1, and IgG2a production was impaired.	pristane	0-8	immunoglobulin heavy variable V1-9	Mus musculus	134-139
35095344-6	2022	When adoptively transferring CD4+ T cells into T cell-deficient mice or coculturing CD4+ T cells and B cells in vitro, it was found that CD4+ T cells derived from pristane-treated mice could help the production of total IgG as well as IgG1/IgG2a in a more efficient manner both in vivo and in vitro.	pristane	163-171	immunoglobulin heavy variable V1-9	Mus musculus	240-245
2926328-3	1989	In the present study using mouse serum-induced thioglycollate-elicited peritoneal M phi (TPM) as a model system for SER expression, mAb SER-4 IgG2a completely blocked rosette formation at 1 microgram/ml.	Thioglycolates	47-61	immunoglobulin heavy variable V1-9	Mus musculus	142-147
2737700-3	1989	Polyanions inhibited ADCC mediated by either IgG2a or IgG2b in a reversible manner.	polyanions	0-10	immunoglobulin heavy variable V1-9	Mus musculus	45-50
2493500-5	1989	It is shown here that anti-CII antibodies produced during primary immune response are IgG-antibodies mainly of IgG2a, IgG1 and IgG2b subclasses while IgM antibodies dominate primary responses elicited by OVA and denatured CII as analyzed with a large panel of hybridomas.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	27-30	immunoglobulin heavy variable V1-9	Mus musculus	111-116
2495968-7	1989	IgG subclass analysis revealed that mice pretreated with DNP-BP had elevated levels of IgG2a and reduced levels of IgG1 as compared to control (TNP-keyhole limpet hemocyanin-pretreated) mice.	dnp-bp	57-63	immunoglobulin heavy variable V1-9	Mus musculus	87-92
2495968-8	1989	Treatment of mice with an anti-interferon-gamma monoclonal antibody, shortly after immunization with DNP-BP, not only reduced anti-DNP IgG2a levels, but prevented the sharp anti-DNP IgE decline that occurred after priming with DNP-OA in alum.	dnp-bp	101-107	immunoglobulin heavy variable V1-9	Mus musculus	135-140
2495968-8	1989	Treatment of mice with an anti-interferon-gamma monoclonal antibody, shortly after immunization with DNP-BP, not only reduced anti-DNP IgG2a levels, but prevented the sharp anti-DNP IgE decline that occurred after priming with DNP-OA in alum.	2,4-Dinitrophenol	101-104	immunoglobulin heavy variable V1-9	Mus musculus	135-140
2522483-3	1989	About 40 to 80% of P388D1 cells phagocytosed SRBC coated with IgG2a subclass anti-SRBC mAb (EA2a) within 60 min, whereas only 10 to 20% of the cells phagocytosed EA2b during the same period.	srbc	45-49	immunoglobulin heavy variable V1-9	Mus musculus	62-67
2494434-9	1989	The unique susceptibility of rat monoclonal IgG1 and IgG2a is likely to be the result of the presence of a lysine residue in a loop of C gamma 1 domain, which therefore is accessible to trypsin.	Lysine	107-113	immunoglobulin heavy variable V1-9	Mus musculus	53-58
3171176-3	1988	Treatment of the Hy-1.2 hybridoma-producing IgG2a-anti-TNP antibodies with ethylmethanesulfonate provided us with a mutant clone, producing antibodies with reduced capacity for C activation.	Ethyl Methanesulfonate	75-96	immunoglobulin heavy variable V1-9	Mus musculus	44-49
2460155-2	1988	An IgG2a monoclonal antibody was prepared and it neutralized two forms of MGI-2 (MGI-2A and MGI-2B) produced by mouse Krebs ascites tumor cells.	krebs	118-123	immunoglobulin heavy variable V1-9	Mus musculus	3-8
3258563-5	1988	Presentation of endogenously synthesized IgG2a by this population of dendritic cells, macrophages, and/or activated B cells was chloroquine sensitive.	Chloroquine	128-139	immunoglobulin heavy variable V1-9	Mus musculus	41-46
3142018-2	1988	Monoclonal antibodies specific for the sialylated form of the GBS type III polysaccharide were highly protective in a mouse model of GBS type III infection, whether of IgM, IgG2a, or IgA isotypes, but monoclonal antibodies specific for the nonsialylated form of the type III antigen were not protective, regardless of isotype.	gbs	62-65	immunoglobulin heavy variable V1-9	Mus musculus	173-178
3142018-2	1988	Monoclonal antibodies specific for the sialylated form of the GBS type III polysaccharide were highly protective in a mouse model of GBS type III infection, whether of IgM, IgG2a, or IgA isotypes, but monoclonal antibodies specific for the nonsialylated form of the type III antigen were not protective, regardless of isotype.	iii polysaccharide	71-89	immunoglobulin heavy variable V1-9	Mus musculus	173-178
2456333-9	1988	Attachment of both TNP and 4-ethoxymethylene-2-phenyloxazolone haptens to the same PEC, followed by treatment with an IgG2a anti-TNP antibody, generates Ts-aff cells specific for both 4-ethoxymethylene-2-phenyloxazolone and TNP.	Oxazolone	184-219	immunoglobulin heavy variable V1-9	Mus musculus	118-123
2833568-6	1988	Sepharose-Protein A affinity-purified isotypes were also studied and showed IgG1 greater than IgG2a greater than or equal to IgG2b much greater than IgG3 activity per microgram of isotype, indicating that competition between isotypes present in high concentrations did not significantly alter the results.	Sepharose	0-9	immunoglobulin heavy variable V1-9	Mus musculus	94-99
3258563-10	1988	The response directed towards endogenous IgG2a expressed in M12.C3.A2 lymphoma cells is chloroquine resistant and considerably more efficient than that stimulated by IgG2a added as exogenous soluble antigen.	Chloroquine	88-99	immunoglobulin heavy variable V1-9	Mus musculus	41-46
2840199-2	1988	The present study demonstrated that monoclonal antibody S1 (IgG2a), which recognized the antigenic determinant of the carbohydrate moiety, showed antibody-dependent cell (or macrophage)-mediated cytotoxicity (ADCC or ADMC) in conjunction with murine splenocytes of both BALB/c and athymic mice.	admc	217-221	immunoglobulin heavy variable V1-9	Mus musculus	60-65
2452817-1	1988	Two murine monoclonal antibodies, SK-930 (isotype IgG2a) and SK-117 (isotype IgG1), were produced from spleen cells of mice immunized against human pancreatic carcinoma cell lines, MIA-PaCa 2 and Panc-1.	sk-930	34-40	immunoglobulin heavy variable V1-9	Mus musculus	50-55
2840199-2	1988	The present study demonstrated that monoclonal antibody S1 (IgG2a), which recognized the antigenic determinant of the carbohydrate moiety, showed antibody-dependent cell (or macrophage)-mediated cytotoxicity (ADCC or ADMC) in conjunction with murine splenocytes of both BALB/c and athymic mice.	Carbohydrates	118-130	immunoglobulin heavy variable V1-9	Mus musculus	60-65
3426185-4	1987	In marked contrast, HANA-flu preparations induced high IgG1, low IgG2a, and very low IgG2b and IgG3 levels of antibody.	hana-flu	20-28	immunoglobulin heavy variable V1-9	Mus musculus	65-70
2964864-2	1987	IgG2a-binding protein isolated from the detergent lysate of P388D1 cells by affinity chromatography on IgG-Sepharose was found to contain four distinct proteins of Mr 50,000, 43,000, 37,000, and 17,000, which could be autophosphorylated upon incubation with [gamma-32P]ATP.	Sepharose	107-116	immunoglobulin heavy variable V1-9	Mus musculus	0-5
2964864-2	1987	IgG2a-binding protein isolated from the detergent lysate of P388D1 cells by affinity chromatography on IgG-Sepharose was found to contain four distinct proteins of Mr 50,000, 43,000, 37,000, and 17,000, which could be autophosphorylated upon incubation with [gamma-32P]ATP.	[gamma-32p	258-268	immunoglobulin heavy variable V1-9	Mus musculus	0-5
2964864-2	1987	IgG2a-binding protein isolated from the detergent lysate of P388D1 cells by affinity chromatography on IgG-Sepharose was found to contain four distinct proteins of Mr 50,000, 43,000, 37,000, and 17,000, which could be autophosphorylated upon incubation with [gamma-32P]ATP.	Adenosine Triphosphate	269-272	immunoglobulin heavy variable V1-9	Mus musculus	0-5
2960544-1	1987	The anti-CD3 antibody BMA030 (IgG2a isotype) induces T cell activation and proliferation if an interaction with monocytes is provided.	bma030	22-28	immunoglobulin heavy variable V1-9	Mus musculus	30-35
3289745-3	1988	The monoclonal antibody, a rat IgG2a, was conjugated with a bifunctional chelating agent, diethylenetriaminepentaacetic acid at a 1:1 molecular ratio and complexed with 111-indium, a procedure which apparently did not alter its binding to peritoneal macrophages and provided relatively stable cell labelling.	Indium-111	169-179	immunoglobulin heavy variable V1-9	Mus musculus	31-36
3426185-6	1987	Mice primed with HANA-flu prior to infection with mouse-adapted virus, produced high IgG2a, moderate IgG1, and low IgG2b and IgG3 levels of serum antibody.	hana-flu	17-25	immunoglobulin heavy variable V1-9	Mus musculus	85-90
3876384-2	1985	Ten monoclonal anti-DNA antibodies (IgG2a or IgG2b), derived from NZB/NZW mice and reactive with natural DNA (duplex and/or heat-denatured), were found to collectively exhibit a diverse binding pattern with six deoxyribohomopolymers.	deoxyribohomopolymers	211-232	immunoglobulin heavy variable V1-9	Mus musculus	36-41
3328861-7	1987	Differences in protein A binding between IgG1 and IgG2a appear to be due to amino acid differences at positions 252 (Thr----Met) and 254 (Thr----Ser) of the heavy chain (EU numbering).	Threonine	117-120	immunoglobulin heavy variable V1-9	Mus musculus	50-55
3328861-7	1987	Differences in protein A binding between IgG1 and IgG2a appear to be due to amino acid differences at positions 252 (Thr----Met) and 254 (Thr----Ser) of the heavy chain (EU numbering).	Threonine	138-141	immunoglobulin heavy variable V1-9	Mus musculus	50-55
3756906-7	1986	528 IgG2a, but not 225 IgG1, was cytotoxic to A431 cells in the presence of activated peritoneal macrophages, as demonstrated by release of incorporated [3H]thymidine.	Tritium	154-156	immunoglobulin heavy variable V1-9	Mus musculus	4-9
3756906-7	1986	528 IgG2a, but not 225 IgG1, was cytotoxic to A431 cells in the presence of activated peritoneal macrophages, as demonstrated by release of incorporated [3H]thymidine.	Thymidine	157-166	immunoglobulin heavy variable V1-9	Mus musculus	4-9
2875752-6	1986	Monoclonal rat IgG2b or mouse IgG2a anti-Thy-1 antibodies with high affinity for Clq prevented acute and chronic mortality of graft-v-host disease (GVHD), however, when injected in irradiated CBA or AKR mice prior to C57BL/6 spleen and/or bone marrow cell transfusion.	(R)-chloroquine	81-84	immunoglobulin heavy variable V1-9	Mus musculus	30-35
2420610-2	1986	This IgG2a antibody, either in soluble form or covalently coupled to Sepharose beads, can activate resting T cells from naive animals to proliferate.	Sepharose	69-78	immunoglobulin heavy variable V1-9	Mus musculus	5-10
2934735-5	1985	Although all three isotypes were active in the antibody-dependent, macrophage-mediated cytotoxicity assay with murine thioglycolate-elicited macrophages, the IgG2a gave the highest percentage of lysis; similar results were obtained in the same assay with human monocytes as effector cells.	Thioglycolates	118-131	immunoglobulin heavy variable V1-9	Mus musculus	158-163
24241522-7	1985	They secrete immunoglobulin (IgG2a or IgG2b) of high affinity and specificity for IAA methyl ester and can be used to quantite picogram amounts of this compound in plant extracts by radio- and enzymeimmunoassay.	methyl 2-(1H-indol-3-yl)acetate	82-98	immunoglobulin heavy variable V1-9	Mus musculus	29-34
3862903-3	1985	The mechanism by which IgG2A from a syngeneic antitumor hyperimmune serum mediates destruction of target cells in the presence of thioglycollate-elicited peritoneal macrophages was investigated by using an in vitro assay system.	Thioglycolates	130-144	immunoglobulin heavy variable V1-9	Mus musculus	23-28
3598464-6	1987	A limited degree of lysis is observed when platelets are incubated with SRBC sensitized with monoclonal IgG2a alone, but no lysis occurs with SRBC bearing comparable amounts of other isotypes.	srbc	72-76	immunoglobulin heavy variable V1-9	Mus musculus	104-109
2959316-3	1987	On the other hand, the binding of IgG2a immune complexes to cell surface Fc gamma 2aR increased the basal activity about 2.5-fold and the forskolin- and NaF-stimulated activities slightly.	Colforsin	138-147	immunoglobulin heavy variable V1-9	Mus musculus	34-39
2959316-3	1987	On the other hand, the binding of IgG2a immune complexes to cell surface Fc gamma 2aR increased the basal activity about 2.5-fold and the forskolin- and NaF-stimulated activities slightly.	Sodium Fluoride	153-156	immunoglobulin heavy variable V1-9	Mus musculus	34-39
3496996-2	1987	Passive transfer of KSm2 (a monoclonal IgG2a antibody directed against the 16 kD polypeptide of Sm) induced IgG antibodies to the other major immunoreactive polypeptides of Sm (28 and 29 kD) in all mice studied, and to polypeptides of the closely related antigen nRNP/Sm in 63% of the mice.	ksm2	20-24	immunoglobulin heavy variable V1-9	Mus musculus	39-44
3756145-6	1986	Simultaneous fusion of the liposomes containing IgG-B1 and -B2 proteins with guanine nucleotide binding stimulatory (G/F) protein/Fc gamma 2aR-deficient cyc- cells resulted in the formation of the hybrid membrane whose adenylate cyclase responds to immune complex formed with IgG2a-subclass antibody (IC2a) by about a 2.7-fold increase in the activity over the control (hybrid membrane between cyc- cells and liposome containing no protein).	Guanine Nucleotides	77-95	immunoglobulin heavy variable V1-9	Mus musculus	276-281
2411572-8	1985	A pattern IgM much greater than IgG1 = IgG3 greater than IgG2a prevailed in responses to the plain dextran and in primary anti-dextran responses to dextran-CSA.	Dextrans	99-106	immunoglobulin heavy variable V1-9	Mus musculus	57-62
2411572-8	1985	A pattern IgM much greater than IgG1 = IgG3 greater than IgG2a prevailed in responses to the plain dextran and in primary anti-dextran responses to dextran-CSA.	Dextrans	127-134	immunoglobulin heavy variable V1-9	Mus musculus	57-62
2411572-8	1985	A pattern IgM much greater than IgG1 = IgG3 greater than IgG2a prevailed in responses to the plain dextran and in primary anti-dextran responses to dextran-CSA.	dextran-csa	148-159	immunoglobulin heavy variable V1-9	Mus musculus	57-62
2411572-9	1985	Another pattern IgG1 greater than IgG3 greater than IgM greater than IgG2a was observed in late anti-dextran responses to dextran-CSA.	Dextrans	101-108	immunoglobulin heavy variable V1-9	Mus musculus	69-74
2411572-9	1985	Another pattern IgG1 greater than IgG3 greater than IgM greater than IgG2a was observed in late anti-dextran responses to dextran-CSA.	dextran-csa	122-133	immunoglobulin heavy variable V1-9	Mus musculus	69-74
2411572-10	1985	The third pattern IgG1 much greater than IgG2a greater than IgG3 approximately equal to IgM was characteristic of anti-CSA antibodies.	Cyclosporine	119-122	immunoglobulin heavy variable V1-9	Mus musculus	41-46
3872815-6	1985	Exposure of maturing B cells to DNP bound to murine IgG2a (MGG) for 30 days does not inhibit growth or receptor expression, but does induce tolerance that is reversible when DNP-MGG is removed.	dnp	32-35	immunoglobulin heavy variable V1-9	Mus musculus	52-57
3872815-6	1985	Exposure of maturing B cells to DNP bound to murine IgG2a (MGG) for 30 days does not inhibit growth or receptor expression, but does induce tolerance that is reversible when DNP-MGG is removed.	dnp	174-177	immunoglobulin heavy variable V1-9	Mus musculus	52-57
6432224-2	1984	These monoclonals, of IgG2a subclass, blocked in vitro insulin secretion induced by arginine in Mouse pancreatic cells.	Arginine	84-92	immunoglobulin heavy variable V1-9	Mus musculus	22-27
3994308-3	1985	Purified McAbs (14AC1) of IgG2a isotype were labelled with Na131I (2mCi/50ml) using the Chloramin-T method.	na131i	59-65	immunoglobulin heavy variable V1-9	Mus musculus	26-31
3919387-2	1985	This system, which is based on the autoimmune NZB mouse strain, has been used to produce a monoclonal IgG2a antibody against the meningococcus group B and Escherichia coli K1 polysaccharides, identical homopolymers of alpha (2----8)-linked units of N-acetylneuraminic acid that are extremely poor immunogens.	Polysaccharides	175-190	immunoglobulin heavy variable V1-9	Mus musculus	102-107
3919387-2	1985	This system, which is based on the autoimmune NZB mouse strain, has been used to produce a monoclonal IgG2a antibody against the meningococcus group B and Escherichia coli K1 polysaccharides, identical homopolymers of alpha (2----8)-linked units of N-acetylneuraminic acid that are extremely poor immunogens.	N-Acetylneuraminic Acid	249-272	immunoglobulin heavy variable V1-9	Mus musculus	102-107
3922883-3	1985	Analysis of the antibody response to oxazolone has revealed different ratios of IgG2a and IgG2b antibodies in mice carrying the Igh-1b allele and in strains carrying alleles a, c, and e. The characteristic ratio of IgG2a and IgG2b isotypes persisted during the whole period of the primary and secondary antibody response of CBA and CBA-Igb Igh-C congenic mice.	Oxazolone	37-46	immunoglobulin heavy variable V1-9	Mus musculus	80-85
3155534-0	1985	Site of binding of IgG2b and IgG2a by mouse macrophage Fc receptors by using cyanogen bromide fragments.	Cyanogen Bromide	77-93	immunoglobulin heavy variable V1-9	Mus musculus	29-34
3155534-1	1985	Cyanogen bromide fragments of murine IgG2b and IgG2a immunoglobulins were used to localize the sequences that are bound by specific IgG2b and IgG2a Fc receptors on murine macrophages.	Cyanogen Bromide	0-16	immunoglobulin heavy variable V1-9	Mus musculus	47-52
3155534-1	1985	Cyanogen bromide fragments of murine IgG2b and IgG2a immunoglobulins were used to localize the sequences that are bound by specific IgG2b and IgG2a Fc receptors on murine macrophages.	Cyanogen Bromide	0-16	immunoglobulin heavy variable V1-9	Mus musculus	142-147
6586943-5	1984	The bulk of ingestion of methacrylate particles is mediated by Fc receptors and significantly more receptors for IgG2B, IgG1, and IgG2A are demonstrable on nu/nu neutrophils; ingestion of particles via these receptors is again higher in nu/nu neutrophils, whereas nu/nu monocytes display a higher uptake via Fc(IgG1) receptors.	Methacrylates	25-37	immunoglobulin heavy variable V1-9	Mus musculus	130-135
6715016-2	1984	IgM, IgG1, IgG2a and IgG2b antibodies at doses up to 500 micrograms induced at best a modest suppression of the IgM response, and reproducibly enhanced the IgG response to DNP-KLH by up to 30-fold.	dnp-klh	172-179	immunoglobulin heavy variable V1-9	Mus musculus	11-16
6358356-6	1983	The primary cleavage for the IgG2a heavy chain appears to be on the COOH terminal side of the interheavy chain disulfides, and secondary cleavage is on the NH2-terminal side.	Disulfides	111-121	immunoglobulin heavy variable V1-9	Mus musculus	29-34
6196873-5	1983	Ml-1 antibody (IgG2a) reacted with all the panel cells tested and immunoprecipitated a molecule of 43,000 daltons from Nonidet P-40 lysates of 3H-glucosamine-labelled cells.	Tritium	143-145	immunoglobulin heavy variable V1-9	Mus musculus	15-20
6196873-5	1983	Ml-1 antibody (IgG2a) reacted with all the panel cells tested and immunoprecipitated a molecule of 43,000 daltons from Nonidet P-40 lysates of 3H-glucosamine-labelled cells.	Glucosamine	146-157	immunoglobulin heavy variable V1-9	Mus musculus	15-20
108802-3	1979	More IgG1 plus IgG2a, IgG2b and IgG3 are thereafter eluted with acid saline.	Sodium Chloride	69-75	immunoglobulin heavy variable V1-9	Mus musculus	15-20
6219064-7	1983	When tested against BW cells, neutrophils have been found to induce high levels of 51Cr release in the presence of IgG1, IgG2a, IgG2b and IgE, but not when IgG3, IgM, IgA or IgD were used.	Chromium-51	83-87	immunoglobulin heavy variable V1-9	Mus musculus	121-126
6811862-1	1982	A murine BALB/c IgG2a (lambda 3) myeloma immunoglobulin SAPC-15 with binding activity for negatively charged polysaccharides has been purified by affinity chromatography, and its interaction with heparin and various other polyanionic antigens has been studied.	Polysaccharides	109-124	immunoglobulin heavy variable V1-9	Mus musculus	16-21
6811862-1	1982	A murine BALB/c IgG2a (lambda 3) myeloma immunoglobulin SAPC-15 with binding activity for negatively charged polysaccharides has been purified by affinity chromatography, and its interaction with heparin and various other polyanionic antigens has been studied.	Heparin	196-203	immunoglobulin heavy variable V1-9	Mus musculus	16-21
7203557-1	1981	A low level of IgG2a antibodies is observed in B10 mice after primary immunization with SRBC.	srbc	88-92	immunoglobulin heavy variable V1-9	Mus musculus	15-20
84712-1	1979	[16-14C]Arginine ([6-14C]Arg) was used as an in vivo pulse label to study BALB/c murine LPC-1 plasmacytoma synthesis and secretion of its tumour-associated M component (IgG2a, kappa).	[16-14c]arginine	0-16	immunoglobulin heavy variable V1-9	Mus musculus	169-174
6404298-1	1983	A hybridoma cell line (26-10) derived from the A/J strain of mice secretes an immunoglobulin (IgG2a-k) which binds digoxin with an association constant of 1.2 nM.	Digoxin	115-122	immunoglobulin heavy variable V1-9	Mus musculus	94-99
6600490-12	1983	In particular, the production of IgG1, IgG2a, and IgG2b are markedly enhanced in the presence of L-BCDF.	l-bcdf	97-103	immunoglobulin heavy variable V1-9	Mus musculus	39-44
6116537-1	1981	The isolation and characterization are described of a conjugate between ricin, and a thy 1.1-specific monoclonal IgG2a murine antibody synthesized using N-succinimidyl-3-(2-pyridyldithio)propionate.	N-succinimidyl 3-(2-pyridyldithio)propionate	153-197	immunoglobulin heavy variable V1-9	Mus musculus	113-118
7229378-3	1981	In the presence of small volumes of hyperimmune serum or IgG2a antibody, thioglycollate-elicited B6 mouse peritoneal cells (PEC) inhibit the growth of AD755 Cl.10 target cells and other cells provided that they express FLV-related antigens.	Thioglycolates	73-87	immunoglobulin heavy variable V1-9	Mus musculus	57-62
7451992-8	1981	Putative receptor obtained by elution from IgG2a-Sepharose rebound equally well to IgG2a-, IgG1- and IgG2b-Sepharose, but did not rebind to IgG3-, F(ab")2-, or BSA-Sepharose.	Sepharose	49-58	immunoglobulin heavy variable V1-9	Mus musculus	43-48
7451992-8	1981	Putative receptor obtained by elution from IgG2a-Sepharose rebound equally well to IgG2a-, IgG1- and IgG2b-Sepharose, but did not rebind to IgG3-, F(ab")2-, or BSA-Sepharose.	Sepharose	107-116	immunoglobulin heavy variable V1-9	Mus musculus	43-48
7451992-8	1981	Putative receptor obtained by elution from IgG2a-Sepharose rebound equally well to IgG2a-, IgG1- and IgG2b-Sepharose, but did not rebind to IgG3-, F(ab")2-, or BSA-Sepharose.	Sepharose	107-116	immunoglobulin heavy variable V1-9	Mus musculus	43-48
7451992-9	1981	Similarly, Fc gamma-binding macromolecules eluted from IgG2b-Sepharose rebound only to IgG2b-, IgG2a- and IgG1-Sepharose rebound only to IgG2b-, IgG2a- and IgG1-Sepharose.	Sepharose	61-70	immunoglobulin heavy variable V1-9	Mus musculus	95-100
7451992-9	1981	Similarly, Fc gamma-binding macromolecules eluted from IgG2b-Sepharose rebound only to IgG2b-, IgG2a- and IgG1-Sepharose rebound only to IgG2b-, IgG2a- and IgG1-Sepharose.	Sepharose	61-70	immunoglobulin heavy variable V1-9	Mus musculus	145-150
991916-2	1976	Tolerance to 2,4-dinitrophenyl (DNP) was induced in C57BL/6J mice using DNP-BALB/c IgG2a conjugate.	2,4-dinitrophenyl	13-30	immunoglobulin heavy variable V1-9	Mus musculus	83-88
681752-3	1978	They also differ in their sensitivity to phospholipase C. The detergent solubilized monomer IgG2a FcR can be removed from solution with a Sepharose IgG2a column, has an S value of 4 to 5 and is resistant to phospholipase C. The solubilized aggregated IgG FcR does not bind to insolubilized IgG2a, has an S value of greater than 19, and is sensitive to phospholipase C treatment.	Sepharose	138-147	immunoglobulin heavy variable V1-9	Mus musculus	92-97
681752-3	1978	They also differ in their sensitivity to phospholipase C. The detergent solubilized monomer IgG2a FcR can be removed from solution with a Sepharose IgG2a column, has an S value of 4 to 5 and is resistant to phospholipase C. The solubilized aggregated IgG FcR does not bind to insolubilized IgG2a, has an S value of greater than 19, and is sensitive to phospholipase C treatment.	Sepharose	138-147	immunoglobulin heavy variable V1-9	Mus musculus	148-153
681752-3	1978	They also differ in their sensitivity to phospholipase C. The detergent solubilized monomer IgG2a FcR can be removed from solution with a Sepharose IgG2a column, has an S value of 4 to 5 and is resistant to phospholipase C. The solubilized aggregated IgG FcR does not bind to insolubilized IgG2a, has an S value of greater than 19, and is sensitive to phospholipase C treatment.	Sepharose	138-147	immunoglobulin heavy variable V1-9	Mus musculus	148-153
668801-2	1978	Inbred strains of mice are distinguishable in terms of early or late kinetics of IgM response, high or low overall IgG response, and the relative expression of IgG1, IgG2a and IgG2b antibody in their response to SRBC.	srbc	212-216	immunoglobulin heavy variable V1-9	Mus musculus	166-171
991916-2	1976	Tolerance to 2,4-dinitrophenyl (DNP) was induced in C57BL/6J mice using DNP-BALB/c IgG2a conjugate.	dnp	32-35	immunoglobulin heavy variable V1-9	Mus musculus	83-88
991916-3	1976	When anti-allotype serum was injected in C57BL/6J mice one day after a single injection of DNP-IgG2a the mice were not tolerant.	dnp	91-94	immunoglobulin heavy variable V1-9	Mus musculus	95-100
1194857-4	1975	The number of binding sites per cell for IgG2a was 4 X 10(5) for thioglycollate-stimulated cells and 1 X 10(5) for normal and P388D1 cells.	Thioglycolates	65-79	immunoglobulin heavy variable V1-9	Mus musculus	41-46
33751882-7	2021	Mice immunized with MBCP-pOVA nanovaccines show a significantly stronger anti-OVA antibody response with a quicker IgG1 and IgG2a antibody production than unmodified NPs.	mbcp-pova	20-29	immunoglobulin heavy variable V1-9	Mus musculus	124-129
1135609-2	1975	The parameters investigated in this paper can be summarized as follows: [1] Within the first week after injection antistreptococcal p0lysaccharide responses are characterized by IgM antibodies, followed by subclass restriction in Balb/c mice to IgG2a antibodies.	p0lysaccharide	132-146	immunoglobulin heavy variable V1-9	Mus musculus	245-250
1234045-1	1975	Within individual sera, mouse IgG1 and IgG2a subclass antibodies against the antigenic determinant oligo-D-alanine are likely to have similar combining sites.	oligo-d-alanine	99-114	immunoglobulin heavy variable V1-9	Mus musculus	39-44
33751882-7	2021	Mice immunized with MBCP-pOVA nanovaccines show a significantly stronger anti-OVA antibody response with a quicker IgG1 and IgG2a antibody production than unmodified NPs.	nanovaccines	30-42	immunoglobulin heavy variable V1-9	Mus musculus	124-129
33592002-10	2021	Sulforaphane-treated mice showed lower circulating levels of type-II-collagen-specific IgG, IgG1, and IgG2a.	sulforaphane	0-12	immunoglobulin heavy variable V1-9	Mus musculus	102-107
33663293-7	2021	In the ammonia exposure group, levels of serum immunoglobulin E and immunoglobulin A were elevated, and the IgG2a:IgG1 ratio in the serum was reduced in a dose-dependent manner.	Ammonia	7-14	immunoglobulin heavy variable V1-9	Mus musculus	108-113
33734700-5	2021	l-arabinose-treated mice exhibited a marked reduction in the productions of total immunoglobulin E (IgE), gliadin-specific IgE, gliadin-specific IgG1, and histamine, with an increase in IgG2a level as compared with gliadin-sensitized mice.	Arabinose	0-11	immunoglobulin heavy variable V1-9	Mus musculus	186-191
33603996-6	2020	Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase.	1-ethylcyclopentyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate	83-86	immunoglobulin heavy variable V1-9	Mus musculus	65-70
33485994-6	2021	BALB/c mice immunization with a DNA plasmid and recombinant protein plus saponin induced development of specific Th1-type immunity, characterized by high levels of IFN-gamma, IL-12, GM-CSF, both T cell subtypes and antileishmanial IgG2a isotype antibodies, before and after infection.	Saponins	73-80	immunoglobulin heavy variable V1-9	Mus musculus	231-236
33166528-10	2020	Moreover, a statistically significant predominance of the IgG1 isotype over that of IgG2a in the sera of mice immunized with ChoD/IFA was observed.	chod/ifa	125-133	immunoglobulin heavy variable V1-9	Mus musculus	84-89
32855679-10	2020	IL-37 administration also decreased the number of eosinophils in the nasal mucosa and the thickness of the nasal mucosa, as well as the serum and nasal lavage fluid levels of IgE, IgG1, IgG2a, IL-4, IL-13, IL-17a and CCL11, but the level of IFN-gamma decreased.	il-37	0-5	immunoglobulin heavy variable V1-9	Mus musculus	186-191
33693294-8	2021	Moreover, 2 weeks after the administration of DCs+PC-KLH to mice, these mice produced PC- and oxLDL-specific IgG2a, compared with no production in the controls.	pc-klh	50-56	immunoglobulin heavy variable V1-9	Mus musculus	109-114
33603996-6	2020	Results: The results showed that total IgG antibody and IgG1 and IgG2a isotypes in OMV immunized mice with mixture of CpG-MPLA adjuvant had a significant increase.	cpg-mpla adjuvant	118-135	immunoglobulin heavy variable V1-9	Mus musculus	65-70
32619431-7	2020	Additionally, the immunized mice with rPvTRAP and rPvTRAP + CFA/IFA had an intermediate-avidity IgG2a antibody but high-avidity IgG2c antibody as well as the mean of serum antibody titers results exhibited that in both rPvTRAP and rPvTRAP + CFA/IFA mouse groups, IgG2a end-point titer (1:3200 and 1:25,600, respectively) was noteworthy lower than IgG2c (1:25,600 and 1:102,400, respectively).	3-chloro-4-fluoroaniline	60-63	immunoglobulin heavy variable V1-9	Mus musculus	96-101
32768955-8	2020	The levels of total and DFE-specific immunoglobulin (Ig)E, and IgG2a in the mice sera were reduced by the bakuchicin.	bakuchicin	106-116	immunoglobulin heavy variable V1-9	Mus musculus	63-68
32619431-7	2020	Additionally, the immunized mice with rPvTRAP and rPvTRAP + CFA/IFA had an intermediate-avidity IgG2a antibody but high-avidity IgG2c antibody as well as the mean of serum antibody titers results exhibited that in both rPvTRAP and rPvTRAP + CFA/IFA mouse groups, IgG2a end-point titer (1:3200 and 1:25,600, respectively) was noteworthy lower than IgG2c (1:25,600 and 1:102,400, respectively).	3-chloro-4-fluoroaniline	60-63	immunoglobulin heavy variable V1-9	Mus musculus	263-268
32619431-7	2020	Additionally, the immunized mice with rPvTRAP and rPvTRAP + CFA/IFA had an intermediate-avidity IgG2a antibody but high-avidity IgG2c antibody as well as the mean of serum antibody titers results exhibited that in both rPvTRAP and rPvTRAP + CFA/IFA mouse groups, IgG2a end-point titer (1:3200 and 1:25,600, respectively) was noteworthy lower than IgG2c (1:25,600 and 1:102,400, respectively).	soy isoflavone aglycone	64-67	immunoglobulin heavy variable V1-9	Mus musculus	96-101
32824648-6	2020	Moreover, SHE significantly attenuated the serum immunoglobulin (Ig)G1 and IgG2a levels in HDM/DNCB-stimulated mice.	Dinitrochlorobenzene	95-99	immunoglobulin heavy variable V1-9	Mus musculus	75-80
32686022-9	2020	Immunization with Pru:Deltagra17 induced high levels of IgG (IgG1 and IgG2a) antibodies and cytokines (interleukin-2 [IL-2], IL-10, IL-12, and interferon gamma [IFN-gamma]), which conferred significant protection in mice challenged with virulent type I (RH), ToxoDB#9 (PYS) strains, or less virulent type II (Pru) strain of T. gondii.	deltagra17	22-32	immunoglobulin heavy variable V1-9	Mus musculus	70-75
32501552-7	2020	RESULTS: We found that the sublingual administration of Omp16+CMP induced a buccal Th1-immune response that modulated the intestinal allergic response with the suppression of symptoms, reduction of IgE and IL-5, and up-regulation of IgG2a and IFN-gamma.	4-chloro-2-cresol	62-65	immunoglobulin heavy variable V1-9	Mus musculus	233-238
32078753-4	2020	The sensitizing capacity of EC was also reduced in the BALB/c mouse model, which showed the significantly decreased levels of specific IgE, IgG, IgG1 and IgG2a, mMCP-1 and histamine in the mouse sera, as well as cytokine secretions of IL-4, IL-5, and IL-13, compared with the raw egg (RE) group.	ec	28-30	immunoglobulin heavy variable V1-9	Mus musculus	154-159
32520090-2	2020	Here, the effects of treatment with ASC on production of TGF-beta and the anti-Ascaris isotypes IgG1 and IgG2a in EAH were evaluated.	eah	114-117	immunoglobulin heavy variable V1-9	Mus musculus	105-110
32520090-8	2020	In the EAH+ASC group, there was significant production of IgG1 at 24 h and 7 d, but of IgG2a only at 7 d. There was statistically greater production of TGF-beta in the EAH+ASC group.	eah	168-171	immunoglobulin heavy variable V1-9	Mus musculus	87-92
32308655-4	2020	Additionally, maternal BBP exposure led to elevated serum IgG1 and IgG2a level in the offspring and increased the IFN-gamma and IL-17 release from collagen-re-stimulated spleen cells.	butylbenzyl phthalate	23-26	immunoglobulin heavy variable V1-9	Mus musculus	67-72
32748595-3	2020	The mice immunized with the ISA 61 VG adjuvant had high safety, and it could induce significantly higher titer of anti-listeriolysin O (LLO) antibody and higher value of IgG2a/IgG1 ratio compared with the group without the adjuvant.	isa 61 vg adjuvant	28-46	immunoglobulin heavy variable V1-9	Mus musculus	170-175
33880435-6	2020	In vivo studies demonstrated that PCPP-R adjuvanted HCV formulation induced higher serum neutralization titers in BALB/c mice and shifted the response towards desirable cellular immunity, as evaluated by antibody isotype ratio (IgG2a/IgG1) and ex vivo analysis of cytokine secreting splenocytes (higher levels of interferon gamma (IFN-gamma) single and tumor necrosis factor alpha (TNF-alpha)/IFN-gamma double producing cells).	pcpp-r	34-40	immunoglobulin heavy variable V1-9	Mus musculus	228-233
32178907-7	2020	Following immunization of mice, three HBc fusions (CFHbp or NadA alone, NadA + CFHbp) were able to induce production of IgG1, IgG2a and IgG2b antibodies reactive against their respective antigens at dilutions in excess of 1:18,000.	cfhbp	51-56	immunoglobulin heavy variable V1-9	Mus musculus	126-131
32178907-7	2020	Following immunization of mice, three HBc fusions (CFHbp or NadA alone, NadA + CFHbp) were able to induce production of IgG1, IgG2a and IgG2b antibodies reactive against their respective antigens at dilutions in excess of 1:18,000.	N-acetyldopamine	60-64	immunoglobulin heavy variable V1-9	Mus musculus	126-131
32178907-7	2020	Following immunization of mice, three HBc fusions (CFHbp or NadA alone, NadA + CFHbp) were able to induce production of IgG1, IgG2a and IgG2b antibodies reactive against their respective antigens at dilutions in excess of 1:18,000.	N-acetyldopamine	72-76	immunoglobulin heavy variable V1-9	Mus musculus	126-131
32178907-7	2020	Following immunization of mice, three HBc fusions (CFHbp or NadA alone, NadA + CFHbp) were able to induce production of IgG1, IgG2a and IgG2b antibodies reactive against their respective antigens at dilutions in excess of 1:18,000.	cfhbp	79-84	immunoglobulin heavy variable V1-9	Mus musculus	126-131
32351209-6	2020	Results showed that the treatment using miltefosine, ICHQ or ICHQ/Mic induced significantly higher anti-parasite IFN-gamma, IL-12, GM-CSF, nitrite and IgG2a isotype antibody levels, which were associated with low IL-4 and IL-10 production.	miltefosine	40-51	immunoglobulin heavy variable V1-9	Mus musculus	151-156
32334909-9	2020	Lower total IgE, OVA-specific IgE, OVA-specific IgG1 and OVA-specific IgG2a levels were found in alpha-TCP treatment of OVA-sensitized mice compared to the OVA group.	alpha-Tocopherol	97-106	immunoglobulin heavy variable V1-9	Mus musculus	70-75
31007088-10	2019	In addition, mannose in the structure of MLCMNP improved IL-6, TNF-alpha and IFN-gamma (>16 fold) cytokines genes expression by macrophage/dendritic cells after exposure in 12 h. Immunization of experimental mice (subcutaneously, two times with 2-week intervals) with 5 microg of HBsAg loaded on MLCMNP nanoparticles increased specific total IgG and IgG2a/IgG1 ratio.	Mannose	13-20	immunoglobulin heavy variable V1-9	Mus musculus	353-358
30885840-7	2019	The results indicated that METH-induced impaired spatial learning abilities were attenuated by co-administration of mouse IL-1 Trap, a dimeric fusion protein that incorporates the extracellular domains of both of the IL-1 receptor components required for IL-1 signaling (IL-1 receptor type 1 and IL-1 receptor accessory protein), linked to the Fc portion of murine IgG2a.	Methamphetamine	27-31	immunoglobulin heavy variable V1-9	Mus musculus	365-370
31437788-5	2019	In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-alpha, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines.	7-hydroxycoumarin	49-52	immunoglobulin heavy variable V1-9	Mus musculus	201-206
31600943-4	2019	When mice were immunized with the FMD vaccine emulsified in SO with VE and GS, significantly higher serum IgG, IgG1, and IgG2a were found than VE and GS used alone.	Vitamin E	68-70	immunoglobulin heavy variable V1-9	Mus musculus	121-126
31386357-1	2019	Following the successful synthesis of a C-functionalized version of the TE1PA ligand, a monopicolinate cyclam, we looked to demonstrate its in vivo properties versus DOTA and NOTA, after conjugation on the 9E7.4 rat antibody, an IgG2a against CD138 murine, which has relevant properties for multiple myeloma targeting.	te1pa	72-77	immunoglobulin heavy variable V1-9	Mus musculus	229-234
31389952-6	2019	Compared with their anionic counterparts, the cationic nanovaccines more efficiently activated DC maturation and induced Th1 immunity; this was suggested by the significantly increased IgG2a/IgG1 ratio and elevated cytokine secretion from Th1 cells, without an enhancement in the Th2 response.	nanovaccines	55-67	immunoglobulin heavy variable V1-9	Mus musculus	185-190
31579449-8	2019	The highest level of IgG2a was observed with Lip DOTAP+imiquimod+SLA more than the control (P<0.001).	imiquimod	45-64	immunoglobulin heavy variable V1-9	Mus musculus	21-26
31240233-8	2019	Furthermore, pGag and pA27L plasmids formulated with SHS, triggered the production of antigen-specific IgG in mice, especially the IgG2a isotype.	pgag	13-17	immunoglobulin heavy variable V1-9	Mus musculus	131-136
31141221-4	2019	Following oral administration of GSLS, mice immunized with an attenuated PrV vaccine diluted in Se-containing physiological saline solution (PSS) provoked a significantly stronger gB-specific serum antibodies response (IgG, IgG1 and IgG2a), enhanced lymphocyte proliferation and cytolytic activity of NK cells, along with higher production of cytokines (IFN-gamma, IL-12, IL-5 and IL-10) by splenocytes.	Selenium	96-98	immunoglobulin heavy variable V1-9	Mus musculus	233-238
31141221-4	2019	Following oral administration of GSLS, mice immunized with an attenuated PrV vaccine diluted in Se-containing physiological saline solution (PSS) provoked a significantly stronger gB-specific serum antibodies response (IgG, IgG1 and IgG2a), enhanced lymphocyte proliferation and cytolytic activity of NK cells, along with higher production of cytokines (IFN-gamma, IL-12, IL-5 and IL-10) by splenocytes.	pss	141-144	immunoglobulin heavy variable V1-9	Mus musculus	233-238
31240233-8	2019	Furthermore, pGag and pA27L plasmids formulated with SHS, triggered the production of antigen-specific IgG in mice, especially the IgG2a isotype.	shs	53-56	immunoglobulin heavy variable V1-9	Mus musculus	131-136
30707297-8	2019	Among these adjuvants, AS02 provided outstanding protection against challenge with pathogenic bacteria from different families and clades; it also induced high titers of IgG1 and IgG2a.	as02	23-27	immunoglobulin heavy variable V1-9	Mus musculus	179-184
31137528-8	2019	Topical SP treatment reduced serum IgE and IgG2a levels and suppressed COX-2 and iNOS expression via blocked mitogen-activated protein kinase (MAPK) pathways in DNCB-induced AD-like lesions.	N-isobutyl-2E-decenamide	8-10	immunoglobulin heavy variable V1-9	Mus musculus	43-48
30780019-10	2019	Vaccination with H2O2-deactivated whole-cell bacteria in mice mainly elicits whole-cell specific antibody titers and balances the IgG2a and IgG1 response, predominantly with IgG3 induction at the later stages, meanwhile provides opsonic protection against challenge with pathogens.	Hydrogen Peroxide	17-21	immunoglobulin heavy variable V1-9	Mus musculus	130-135
30620923-5	2019	Treatment with WPI-EGCG, in turn, decreased the levels of IgG2a and mMCP-1 in serum of mice, possibly by the modulation of Th1/Th2 response and the increase of CD4+ Foxp3+ LAP- T and IL-17A+CD4+ T (Th17) cell populations.	epigallocatechin gallate	19-23	immunoglobulin heavy variable V1-9	Mus musculus	58-63
30803844-4	2019	Poly(I:C) and CpG readily adsorbed onto AH and this combination adjuvant induced a stronger IgG1 and IgG2a immune response with a significant increase of antibody avidity.	Poly I-C	0-8	immunoglobulin heavy variable V1-9	Mus musculus	101-106
30941133-4	2019	Immunization of mice with r-PAbxpB elicited significantly high titer antibodies comprising IgG1:IgG2a isotypes in 1:1 ratio, balanced up-regulation of both Th1 (IL2, IL12, IFN-gamma) and Th2 (IL4, IL5, IL10) cytokines and high frequencies of CD4+ and CD8+ T cell subsets.	r-pabxpb	26-34	immunoglobulin heavy variable V1-9	Mus musculus	96-101
30781796-7	2019	Removing all potential N-glycosylation sites from the C2V3 domain by site-specific mutagenesis reversed the vaccine-induced immune response towards a Th1-dominated T-cell response and a balanced IgG2a/IgG1 ratio.	Nitrogen	23-24	immunoglobulin heavy variable V1-9	Mus musculus	195-200
30788740-6	2019	In the serum of mice inoculated with hybridoma, IgM and IgG2a antibodies recognizing the tetrasaccharide epitope in the structure of synthetic capsular polysaccharide were simultaneously determined.	tetrasaccharide	89-104	immunoglobulin heavy variable V1-9	Mus musculus	56-61
30577861-8	2018	EAS-adjuvanted vaccine elicited significantly stronger IgG1 and IgG2a antibodies and higher concentrations of Th1 (IFN-gamma and IL-2) cytokines compared to the W/O vaccine or antigen alone.	CHEMBL4167713	0-3	immunoglobulin heavy variable V1-9	Mus musculus	64-69
30419248-8	2019	Our finding was demonstrated by estimating ex-vivo Th1 and Th2 cytokines, flow cytometric analysis of Treg, T-helper memory, and CD8+ cells and determining serum IgG2a/IgG1 titer shift in BCG-vaccinated animals treated with juglone.	juglone	224-231	immunoglobulin heavy variable V1-9	Mus musculus	162-167
31230449-3	2019	Compared with PR8 infection, BJ501 induced a more rapid increase of virus-specific IgA and IgG antibodies in the nasal lavage fluid and a higher ratio of IgG1/IgG2a, indicating a stronger Th2 response to BJ501 in mucosal immunity.	bj501	29-34	immunoglobulin heavy variable V1-9	Mus musculus	159-164
31234191-11	2019	COS treatment significantly reduced serum IgE and IgG1 levels, and increased IgG2a levels (p < 0.05).	carbonyl sulfide	0-3	immunoglobulin heavy variable V1-9	Mus musculus	77-82
30599891-13	2019	Anticollagen IgG1 and IgG2a levels decreased in the serum of ECAP-treated mice.	epicatechin-3-O-allopyranoside	61-65	immunoglobulin heavy variable V1-9	Mus musculus	22-27
29382591-9	2018	The DEX-NP vaccine elicited much stronger OVA-specific IgG2a production than coadministered soluble OVA plus CpG oligodeoxynucleotides.	dex-np	4-10	immunoglobulin heavy variable V1-9	Mus musculus	55-60
30581437-6	2018	Further, isotype switching from IgG1 to IgG2a was observed in mice immunized with rBCG vaccines and correlated with an increased viral clearance, as compared to unimmunized animals.	rbcg	82-86	immunoglobulin heavy variable V1-9	Mus musculus	40-45
29382591-10	2018	B-cell binding of the DEX-NP vaccine was critical for IgG2a production.	dex-np	22-28	immunoglobulin heavy variable V1-9	Mus musculus	54-59
30014237-5	2018	Moreover, by assessing the IgG2a/IgG1 ratio, a prevalence of Th1 cytotoxic response in tumor-bearing mice receiving zoledronate by means of RBCs has been observed.	Zoledronic Acid	116-127	immunoglobulin heavy variable V1-9	Mus musculus	27-32
30244623-6	2018	Moreover, IgG2a production significantly increased in ISS-treated mice.	ISS	54-57	immunoglobulin heavy variable V1-9	Mus musculus	10-15
29908151-7	2018	In addition, chimera and/or saponin-immunized mice presented significantly lower parasite burden in distinct evaluated organs, when compared to the controls, besides higher levels of IFN-gamma, IL-2, IL-12, and GM-CSF, and an IgG2a isotype-based humoral response.	Saponins	28-35	immunoglobulin heavy variable V1-9	Mus musculus	226-231
29706292-6	2018	Only G3 enhanced the IgG2a subclass reflecting a Th1 response, whereas Al(OH)3 even abrogated the IgG2a production.	Aluminum Hydroxide	71-78	immunoglobulin heavy variable V1-9	Mus musculus	98-103
29870743-7	2018	However, all the liposomal groups containing both DT and poly(I:C) showed enhanced IgG2a titers compared to DT/poly(I:C) solution, indicating that the immune response was skewed towards a Th1 direction.	Poly I-C	57-65	immunoglobulin heavy variable V1-9	Mus musculus	83-88
29484729-4	2018	Oral administration of PBE to mice with 2,4-dinitrochlorobenzene (DNCB)-induced AD lessened dermatitis scores and scratching behavior and significantly reduced measures of epidermal thickness, infiltration of mast cells and eosinophils, levels of immunoglobulin E (IgE), and IgG1 /IgG2a ratio in serum.	pycnogenols	23-26	immunoglobulin heavy variable V1-9	Mus musculus	281-286
29484729-4	2018	Oral administration of PBE to mice with 2,4-dinitrochlorobenzene (DNCB)-induced AD lessened dermatitis scores and scratching behavior and significantly reduced measures of epidermal thickness, infiltration of mast cells and eosinophils, levels of immunoglobulin E (IgE), and IgG1 /IgG2a ratio in serum.	Dinitrochlorobenzene	66-70	immunoglobulin heavy variable V1-9	Mus musculus	281-286
30041879-6	2018	Compared to the control group that had received PBS, vaccinated mice showed significantly higher cellular recall responses and antigen-specific IgG2a, IgG1, and gastric IgA antibody titers.	Lead	48-51	immunoglobulin heavy variable V1-9	Mus musculus	144-149
28655574-5	2018	Our previous studies have shown that treatment of L. donovani infected mice with cisplatin along with herbal drugs resulted in decreased parasite load with heightened delayed type hypersensitivity responses (DTH), increased levels of IgG2a, IFN-gamma, IL-2, CD4+ cells, NK 1.1 cells over that of IgG1, IL-4, 1L-10, CD8+ and CD19 in infected mice.	Cisplatin	81-90	immunoglobulin heavy variable V1-9	Mus musculus	234-239
29405788-8	2018	At 400 mg/kg of butanol fraction, the normalized mean secondary production of IgG1 and IgG2a antibodies were 9.0 and 7.7, respectively.	Butanols	16-23	immunoglobulin heavy variable V1-9	Mus musculus	87-92
29279589-6	2017	IFN-gamma/ Interleukin (IL)-4 and IgG2a/IgG1 ratios demonstrated the highest IFN-gamma and IgG2a levels in the group receiving LACK-TSA fusion.	trichostatin A	132-135	immunoglobulin heavy variable V1-9	Mus musculus	34-39
29682589-6	2018	As expected, strong serum IgG, IgG1, and IgG2a antibodies as well as a dose sparing effect were induced by both Al(OH)3 and MPLA, but no mucosal IgA antibodies were detected.	Aluminum Hydroxide	112-119	immunoglobulin heavy variable V1-9	Mus musculus	41-46
29035857-4	2017	Elevated levels of total IgE and TES-antigen-specific IgM were detected on day 12 after the first infection, followed by IgG and IgG1, and later by IgG3, IgG2a and IgG2b; specific IgE response was not detected.	TES	33-36	immunoglobulin heavy variable V1-9	Mus musculus	154-159
28671003-6	2018	Entrapment of erythrocytes entrapped antigen in the PB and further crosslinking with glutaraldehyde also resulted in significant alterations of IgG1/IgG2a ratio, indicating a shift towards humoral response.	Glutaral	85-99	immunoglobulin heavy variable V1-9	Mus musculus	149-154
28970116-4	2018	Immunogenicity of SP-Ld was measured by detecting protease specific-IgG, IgG1 and IgG2a levels by ELISA.	sp-ld	18-23	immunoglobulin heavy variable V1-9	Mus musculus	82-87
28970116-7	2018	SP-Ld vaccinated Balb/c mice resulted significant reduction of parasite burden with increased levels of IgG2a and decreased levels of IgG1.	sp-ld	0-5	immunoglobulin heavy variable V1-9	Mus musculus	104-109
29032899-8	2017	Furthermore, significantly higher levels of IgG, IgG1, or IgG2a were detected in sera from mice immunized with GWP or pooled peptides, and significantly higher levels of IFN-gamma or TNF-alpha secreted by CD4+ T cells from R. rickettsii-infected mice were detected after immunization with GWP.	2-cyclopropyl-1H-imidazole-4-carboxamide	111-114	immunoglobulin heavy variable V1-9	Mus musculus	58-63
29279589-6	2017	IFN-gamma/ Interleukin (IL)-4 and IgG2a/IgG1 ratios demonstrated the highest IFN-gamma and IgG2a levels in the group receiving LACK-TSA fusion.	trichostatin A	132-135	immunoglobulin heavy variable V1-9	Mus musculus	91-96
28863235-9	2017	DHL-HisZn treatment significantly suppressed OVA-specific immunoglobulin E (IgE) but enhanced OVA-specific IgG2a in OVA-sensitized and nasal-challenged mice.	zinc histidine dithiooctanamide	0-9	immunoglobulin heavy variable V1-9	Mus musculus	107-112
29072334-5	2017	When co-immunized with BES-mIL-12-Spider and BDES-sPfCSP2-WPRE-Spider, the mouse number for high IgG2a/IgG1 ratios and the geometric mean in this group were both increased as compared with those of the other groups, indicating a shift towards a Th1-type response following immunization with BES-mIL-12-Spider.	bes-mil-12	23-33	immunoglobulin heavy variable V1-9	Mus musculus	97-102
29072334-5	2017	When co-immunized with BES-mIL-12-Spider and BDES-sPfCSP2-WPRE-Spider, the mouse number for high IgG2a/IgG1 ratios and the geometric mean in this group were both increased as compared with those of the other groups, indicating a shift towards a Th1-type response following immunization with BES-mIL-12-Spider.	bes-mil-12	291-301	immunoglobulin heavy variable V1-9	Mus musculus	97-102
29160801-7	2017	In the sera, total IgE, IgG1, and OVA-specific IgG1 were reduced by astaxanthin exposure and IgG2a and OVA-specific IgG2a were enhanced via oral administration of astaxanthin.	astaxanthine	163-174	immunoglobulin heavy variable V1-9	Mus musculus	93-98
29160801-7	2017	In the sera, total IgE, IgG1, and OVA-specific IgG1 were reduced by astaxanthin exposure and IgG2a and OVA-specific IgG2a were enhanced via oral administration of astaxanthin.	astaxanthine	163-174	immunoglobulin heavy variable V1-9	Mus musculus	116-121
28943194-6	2017	However, the co-encapsulation of OVA and poly(I:C) in nanoparticles significantly increased the IgG2a response compared to OVA/poly(I:C) solution.	Poly I-C	41-49	immunoglobulin heavy variable V1-9	Mus musculus	96-101
27460490-8	2017	However, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColII IgG2a, PGE2, TNF-alpha, and IL-17 compared with those in the CIA group (P<0.05 or P<0.01).	pc	36-38	immunoglobulin heavy variable V1-9	Mus musculus	160-165
28553635-10	2017	The humoral response of these alcoholic fractions and withaferin-A shows increased IgG2a levels when compared with IgG1 in treated mice.	withaferin A	54-66	immunoglobulin heavy variable V1-9	Mus musculus	83-88
28577436-3	2017	The oral administration of UAA showed a decrease in clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum IgG1 and IgG2a levels.	6-Carboxymethyluracil	27-30	immunoglobulin heavy variable V1-9	Mus musculus	150-155
27637556-10	2017	PC-specific IgG1 and IgG2a were significantly higher after TCI in auricle skin compared to controls and compared to TCI in back skin.	tci	59-62	immunoglobulin heavy variable V1-9	Mus musculus	21-26
28165193-2	2017	In vivo, both polysaccharides reduced the levels of OVA-specific IgE, IgE-dependent basophil degranulation and IgG2a antibodies, but had no effect on the levels of OVA-specific IgA or IgG1.	Polysaccharides	14-29	immunoglobulin heavy variable V1-9	Mus musculus	111-116
28304351-7	2017	The 21H27 anti-CTN mcAb was the IgG2a antibody subclass, and cross-reactivity results indicated that anti-CTN mcAb is specific to CTN with high affinity (2.0 x 108 L/mol).	Citrinin	15-18	immunoglobulin heavy variable V1-9	Mus musculus	32-37
27886660-8	2017	Immunization of 6-8-week-old female BALB/c mice with a combination of dtLLO mixed with E protein elicited a robust specific humoral response with isotype diversification of immunoglobulin (Ig)G antibodies (IgG1 and IgG2a).	dtllo	70-75	immunoglobulin heavy variable V1-9	Mus musculus	215-220
27737611-3	2017	Vaccination of mice with Tc24 formulated with monophosphoryl-lipid A (MPLA) adjuvant results in a Th1 skewed immune response with elevated IgG2a and IFNgamma levels and a statistically significant decrease in parasitemia following T. cruzi challenge.	tc24	25-29	immunoglobulin heavy variable V1-9	Mus musculus	139-144
27737611-3	2017	Vaccination of mice with Tc24 formulated with monophosphoryl-lipid A (MPLA) adjuvant results in a Th1 skewed immune response with elevated IgG2a and IFNgamma levels and a statistically significant decrease in parasitemia following T. cruzi challenge.	monophosphoryl lipid A	46-68	immunoglobulin heavy variable V1-9	Mus musculus	139-144
27737611-3	2017	Vaccination of mice with Tc24 formulated with monophosphoryl-lipid A (MPLA) adjuvant results in a Th1 skewed immune response with elevated IgG2a and IFNgamma levels and a statistically significant decrease in parasitemia following T. cruzi challenge.	monophosphoryl lipid A	70-74	immunoglobulin heavy variable V1-9	Mus musculus	139-144
28814229-7	2017	IgG2a levels in mice were enhanced using the common aluminum phosphate-adsorbed B. pertussis whole-cell vaccine, and IgG1 levels did not increase significantly.	aluminum phosphate	52-70	immunoglobulin heavy variable V1-9	Mus musculus	0-5
28049560-6	2017	In the results, the administration of the recombinant protein plus saponin induced a specific IFN-gamma, IL-12 and GM-CSF production, as well as high IgG2a isotype antibody levels, which protected mice against a challenge using L. amazonensis promastigotes.	Saponins	67-74	immunoglobulin heavy variable V1-9	Mus musculus	150-155
27900412-8	2017	Furthermore, DMB decreased interferon (IFN)-gamma, increased IL-4 concentration in the mice splenocytes and the ratio of IgG1/IgG2a in the serum.	demethyleneberberine	13-16	immunoglobulin heavy variable V1-9	Mus musculus	126-131
27872951-7	2017	VEGF-specific IgG2a and IgG2b antibodies as well as type 1 cytokines were stimulated by DTT-VEGF vaccination.	Dithiothreitol	88-91	immunoglobulin heavy variable V1-9	Mus musculus	14-19
27574776-5	2016	The results showed that CBG enhanced FIST-specific IgG and IgG2a, the levels of interferon-gamma (IFNgamma) and nitric oxide (NO), and the splenocyte proliferation response induced by concanavalin A, lipopolysaccharide, and FIST.	cinobufagin	24-27	immunoglobulin heavy variable V1-9	Mus musculus	59-64
27785602-13	2017	Results showed that rROP18 in nanospheres administered intra-nasally elicited elevated responses of specific IgA and IgG2a as compared to groups inoculated intra-nasally with rROP18 alone, or injected subcutaneously with rROP18 in montanide adjuvant.	rrop18	20-26	immunoglobulin heavy variable V1-9	Mus musculus	117-122
27387374-7	2016	Recombinant Ts14-3-3 formulated with an ISA50v2 adjuvant produced strong total IgG and balanced IgG1 and IgG2a responses in vaccinated mice and stimulated mouse splenocytes to produce high levels of Th1 (INF-gamma, IL-2) and Th2 (IL4, IL5) cytokines.	isa50v2 adjuvant	40-56	immunoglobulin heavy variable V1-9	Mus musculus	105-110
27543726-9	2016	Myrcene increased OVA-specific IgG2a titer, suggesting induction of Th1-immune response.	myrcene	0-7	immunoglobulin heavy variable V1-9	Mus musculus	31-36
28127359-7	2016	The IgG2a levels were clearly higher in pcHydI+pcMIL12 group in comparison with the groups of pcHydI alone, empty plasmid, and PBS.	Lead	127-130	immunoglobulin heavy variable V1-9	Mus musculus	4-9
27085175-4	2016	In mice, GLA/SE-adjuvanted gp350 generated high IgG titers (both IgG1 and IgG2a/c subtypes), elevated EBV-neutralizing antibody titers, and robust poly-functional anti-gp350 CD4(+) T cell responses.	Selenium	13-15	immunoglobulin heavy variable V1-9	Mus musculus	74-79
26815845-11	2016	CII-inoculated BALB/c IgG1(+/+) and IgG1(-/-) mice had much lower CII-specific IgG2a/c titers than did C57BL/6 mice and failed to develop CIA but developed passive CIA when given ArthritoMab.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	0-3	immunoglobulin heavy variable V1-9	Mus musculus	79-84
27082998-6	2016	The IgG subclass pattern with high titer of IgG1 (Th2-type) but low titer of IgG2a (Th1-type) was also found in the surfactin-treated mice.	surfactin peptide	116-125	immunoglobulin heavy variable V1-9	Mus musculus	77-82
27085175-4	2016	In mice, GLA/SE-adjuvanted gp350 generated high IgG titers (both IgG1 and IgG2a/c subtypes), elevated EBV-neutralizing antibody titers, and robust poly-functional anti-gp350 CD4(+) T cell responses.	gp350	27-32	immunoglobulin heavy variable V1-9	Mus musculus	74-79
27156804-4	2016	Primary immunization with r-b-flagellin (10mug) followed by two booster shots was sufficient to generate a robust humoral response, which was predominantly a T helper 2 (Th2) type response consisting mainly of subtype IgG1 and low levels of IgG2a.	r-b-flagellin	26-39	immunoglobulin heavy variable V1-9	Mus musculus	241-246
27121231-5	2016	FC-99 also decreased the levels of total immunoglobulin G (IgG), total IgG2a and IgM in sera, as well as the activation of B cells in the spleens of MRL/lpr mice.	Fluorad FC99	0-5	immunoglobulin heavy variable V1-9	Mus musculus	71-76
26987867-3	2016	The mesoporous silica nanoparticle promotes both Th1 and Th2 immune responses, as it accelerates lymphocytes proliferation, stimulates IFN-gamma, IL-2, IL-4, and IL-10 cytokine secretion by lymphocytes ex vivo, and increases IgG, IgG1, IgG2a, IgM, and IgA antibody titers in mice serum compared with those of alum and adjuvant-free groups.	Silicon Dioxide	15-21	immunoglobulin heavy variable V1-9	Mus musculus	236-241
26484633-9	2016	Oral administration of CS to mice at 50, 75, 100 or 200 mug/kg body weight for 10 days led to enhanced levels of total IgG, IgG1, IgG2a and IgG2b in ovalbumin-immunized mice as well as ex vivo lymphocyte proliferation and levels of TH1 (IL-2, IFNgamma) and TH2 (IL-4, IL-10) cytokines produced by their cultured splenocytes.	Cesium	23-25	immunoglobulin heavy variable V1-9	Mus musculus	130-135
25942514-5	2016	Mice colonized with Lmix and sensitized to the Bet v 1 allergen showed significantly lower levels of allergen-specific IgE, IgG1 and IgG2a and an elevated total IgA level in the sera and intestinal lavages as well as an increased transforming growth factor (TGF)-beta level compared with the sensitized GF mice.	lmix	20-24	immunoglobulin heavy variable V1-9	Mus musculus	133-138
26932317-5	2016	Mice immunized with OprI-Mic3-1-R induced an immune response with mixed T helper (Th)1 and Th2 properties (high levels of both immunoglobulin (Ig)G1 and IgG2a and of interleukin (IL)-10, IL-12(p70) and interferon-gamma responses) whereas Mic3-1-R+saponin induced a clear Th2-biased response (low IgG2a and high IL-4 and IL-10).	opri-mic3-1-r	20-33	immunoglobulin heavy variable V1-9	Mus musculus	153-158
26932317-5	2016	Mice immunized with OprI-Mic3-1-R induced an immune response with mixed T helper (Th)1 and Th2 properties (high levels of both immunoglobulin (Ig)G1 and IgG2a and of interleukin (IL)-10, IL-12(p70) and interferon-gamma responses) whereas Mic3-1-R+saponin induced a clear Th2-biased response (low IgG2a and high IL-4 and IL-10).	opri-mic3-1-r	20-33	immunoglobulin heavy variable V1-9	Mus musculus	296-301
26932317-5	2016	Mice immunized with OprI-Mic3-1-R induced an immune response with mixed T helper (Th)1 and Th2 properties (high levels of both immunoglobulin (Ig)G1 and IgG2a and of interleukin (IL)-10, IL-12(p70) and interferon-gamma responses) whereas Mic3-1-R+saponin induced a clear Th2-biased response (low IgG2a and high IL-4 and IL-10).	mic3-1-r	25-33	immunoglobulin heavy variable V1-9	Mus musculus	153-158
26932317-5	2016	Mice immunized with OprI-Mic3-1-R induced an immune response with mixed T helper (Th)1 and Th2 properties (high levels of both immunoglobulin (Ig)G1 and IgG2a and of interleukin (IL)-10, IL-12(p70) and interferon-gamma responses) whereas Mic3-1-R+saponin induced a clear Th2-biased response (low IgG2a and high IL-4 and IL-10).	mic3-1-r	25-33	immunoglobulin heavy variable V1-9	Mus musculus	296-301
26318416-7	2016	RESULTS: The results showed that farnesol supplementation increased serum farnesol concentration dose-dependently, significantly increased (P<0.05) OVA-specific IgG2a/IgE antibody titre ratios, but decreased total IgE levels.	Farnesol	33-41	immunoglobulin heavy variable V1-9	Mus musculus	164-169
26318416-7	2016	RESULTS: The results showed that farnesol supplementation increased serum farnesol concentration dose-dependently, significantly increased (P<0.05) OVA-specific IgG2a/IgE antibody titre ratios, but decreased total IgE levels.	Farnesol	74-82	immunoglobulin heavy variable V1-9	Mus musculus	164-169
26916550-14	2016	Anticollagen IgG1 and IgG2a levels decreased in the serum of kinsenoside-treated mice.	3-glucopyranosyloxybutanolide	61-72	immunoglobulin heavy variable V1-9	Mus musculus	22-27
24662018-10	2016	However, immunization with TLA-Montanide ISA 763 resulted in an increase in IgG2a compared to the unadjuvanted control (p < 0.001).	tla-montanide	27-40	immunoglobulin heavy variable V1-9	Mus musculus	76-81
24662018-12	2016	CONCLUSION: We conclude that the immunization of BALB/c mice with a vaccine formulated with TLA and Montanide ISA 763 generated a protective immune response against L. (L.) amazonensis, characterized by an intense production of IgG2a.	tert-butyl acetate	92-95	immunoglobulin heavy variable V1-9	Mus musculus	228-233
24662018-12	2016	CONCLUSION: We conclude that the immunization of BALB/c mice with a vaccine formulated with TLA and Montanide ISA 763 generated a protective immune response against L. (L.) amazonensis, characterized by an intense production of IgG2a.	montanide	100-109	immunoglobulin heavy variable V1-9	Mus musculus	228-233
27355819-7	2016	RESULTS: Oral administration of TMB suppressed allergic inflammation symptoms, such as histopathological analysis and ear thickness, in addition to serum IgE, DFE-specific IgE and IgG2a levels.	1,2,4,5-tetramethoxybenzene	32-35	immunoglobulin heavy variable V1-9	Mus musculus	180-185
26721350-8	2016	We observed that enrofloxacin treatment of adult mice leads to significant decrease of anti-OVA IgG2a production while synthesis of anti-OVA IgE was not changed.	Enrofloxacin	17-29	immunoglobulin heavy variable V1-9	Mus musculus	96-101
26721350-10	2016	On the other hand, treatment of young mice with enrofloxacin significantly upregulates the production of anti-OVA IgE and inhibits the secretion of anti-OVA IgG2a antibodies.	Enrofloxacin	48-60	immunoglobulin heavy variable V1-9	Mus musculus	157-162
26707217-5	2016	Active immunization of mice with recombinant antigens EcpA, EcpD, IutA, or IroN elicited high levels of total IgG antibody of IgG1/IgG2a isotypes, and were determined to be highly protective against E. coli infection in lethal and non-lethal sepsis challenges.	Iron	75-79	immunoglobulin heavy variable V1-9	Mus musculus	131-136
25691089-4	2016	The results indicated that levels of serum IgG1, IgG2b and IgG3 in post-natal day 21 BTBR mice was significantly higher than FVB mice, regardless of sex, resulting in higher IgG1:IgG2a ratios in BTBR mice than in FVB mice (statistical significance in males).	btbr	85-89	immunoglobulin heavy variable V1-9	Mus musculus	179-184
25691089-4	2016	The results indicated that levels of serum IgG1, IgG2b and IgG3 in post-natal day 21 BTBR mice was significantly higher than FVB mice, regardless of sex, resulting in higher IgG1:IgG2a ratios in BTBR mice than in FVB mice (statistical significance in males).	btbr	195-199	immunoglobulin heavy variable V1-9	Mus musculus	179-184
26570984-4	2016	Oral administration of OAA decreased the clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum total and anti-type II collagen IgG, IgG1, and IgG2a levels.	Oxaloacetic Acid	23-26	immunoglobulin heavy variable V1-9	Mus musculus	177-182
26379475-8	2015	Serum type-II collagen-specific immunoglobulin (Ig) IgG2a antibodies were significantly lower in EGCG-fed mice compared to PBS-treated mice.	epigallocatechin gallate	97-101	immunoglobulin heavy variable V1-9	Mus musculus	52-57
26701750-8	2015	IgG2a response, high levels of IFN-gamma, TNF-alpha and lower levels of IL-10 were detected in mice treated with the immucillins and Glucantime.	immucillins	117-128	immunoglobulin heavy variable V1-9	Mus musculus	0-5
26701750-8	2015	IgG2a response, high levels of IFN-gamma, TNF-alpha and lower levels of IL-10 were detected in mice treated with the immucillins and Glucantime.	Meglumine Antimoniate	133-143	immunoglobulin heavy variable V1-9	Mus musculus	0-5
26423798-6	2015	Mice vaccinated with MOMP+Montanide+CpG developed high levels of C. muridarum-specific antibodies, with a high IgG2a/IgG1 ratio and neutralizing titres.	montanide	26-35	immunoglobulin heavy variable V1-9	Mus musculus	111-116
26190624-5	2015	When administered with high concentrations of silicone oil microdroplets, OVA formulations elicited strong anti-OVA IgG1 and IgG2a antibody responses.	Silicone Oils	46-58	immunoglobulin heavy variable V1-9	Mus musculus	125-130
26467986-9	2015	Dietary RPE inhibited the DNCB-induced enhancement of serum IgE and IgG1 levels, whereas it increased the serum IgG2a level in DNCB-treated mice.	Dinitrochlorobenzene	127-131	immunoglobulin heavy variable V1-9	Mus musculus	112-117
24395558-7	2015	Following MSC treatment pathogenic PG-specific IgG2a antibodies in serum decreased.	pg	35-37	immunoglobulin heavy variable V1-9	Mus musculus	47-52
26259611-10	2015	The lesioned sciatic nerves of Thy1-YFP-H mice injected with a single dose of CD300f-IgG2a show long lasting effects on nerve regeneration characterized by a lower number of YFP-positive fibres growing into the tibial nerve after 10 days post lesion (dpl) and a delayed functional recovery when compared to PBS- or IgG2a-administered control groups.	Lead	307-310	immunoglobulin heavy variable V1-9	Mus musculus	85-90
26192358-3	2015	Here we developed a suitable platform for the large scale production of recombinant Tc24 (rTc24) and show that when rTc24 is combined with a monophosphoryl-lipid A (MPLA) adjuvant, the formulated vaccine induces a Th1-biased immune response in mice, comprised of elevated IgG2a antibody levels and interferon-gamma levels from splenocytes, compared to controls.	monophosphoryl lipid A	141-163	immunoglobulin heavy variable V1-9	Mus musculus	272-277
26192358-3	2015	Here we developed a suitable platform for the large scale production of recombinant Tc24 (rTc24) and show that when rTc24 is combined with a monophosphoryl-lipid A (MPLA) adjuvant, the formulated vaccine induces a Th1-biased immune response in mice, comprised of elevated IgG2a antibody levels and interferon-gamma levels from splenocytes, compared to controls.	monophosphoryl lipid A	165-169	immunoglobulin heavy variable V1-9	Mus musculus	272-277
26160291-11	2015	This Th1-type cellular response observed in rLiHyV/saponin vaccinated mice was accompanied by the induction of parasite-specific IgG2a isotype antibodies.	Saponins	51-58	immunoglobulin heavy variable V1-9	Mus musculus	129-134
26113229-5	2015	Instead, concurrent cutaneous exposure to mite allergens and silica nanoparticles resulted in the low-level production of allergen-specific IgGs, including both the Th2-related IgG1 and Th1-related IgG2a subtypes, with few changes in allergen-specific IgE concentrations and in Th1 and Th2 immune responses.	Silicon Dioxide	61-67	immunoglobulin heavy variable V1-9	Mus musculus	198-203
25905462-8	2015	RESULTS: The mice with thalidomide treatment showed significantly reduced levels of allergen-induced BALF and lung inflammation, AHR, and the expression of a number of pro-inflammatory cytokines and mediators including Th2 related, IL-17 cytokines, and altered levels of allergen-specific IgG1/IgG2a.	Thalidomide	23-34	immunoglobulin heavy variable V1-9	Mus musculus	294-299
25573403-9	2015	Compared to OVA-induced hallmarks of asthma, oral administration of zerumbone induced lower OVA-specific immunoglobulin E (IgE) and higher IgG2a antibody production, attenuated airway hyperresponsiveness, prevented eosinophilic pulmonary infiltration, and ameliorated mucus hypersecretion.	zerumbone	68-77	immunoglobulin heavy variable V1-9	Mus musculus	139-144
25499728-3	2015	Intraperitoneal injection of PHPS suppressed the allergic reaction by modulating serum IgE, IgG1 and IgG2a levels in mice.	osalmide	29-33	immunoglobulin heavy variable V1-9	Mus musculus	101-106
26594606-3	2015	In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum.	galactosucrose	23-35	immunoglobulin heavy variable V1-9	Mus musculus	166-171
25857203-4	2015	Some studies indicate that treatment with progesterone, a chief female reproductive steroid, can suppress IgG2a/2c autoAb production.	Steroids	84-91	immunoglobulin heavy variable V1-9	Mus musculus	106-111
25775390-2	2015	Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers, the activities of natural killer cells (NK) and cytotoxic T lymphocytes (CTL), T cells proliferation, and phagocytic capacity of peritoneal macrophages.	srcps	27-32	immunoglobulin heavy variable V1-9	Mus musculus	87-92
24339889-5	2013	A DEX-based nanovaccine containing OVA and lipopolysaccharide (LPS) as a DC stimulus induced strong OVA peptide-specific CD4(+) and CD8(+) T cell proliferation both in vitro and upon systemic application in mice, as well as a robust OVA-specific humoral immune response (IgG1>IgG2a) in vivo.	Dextrans	2-5	immunoglobulin heavy variable V1-9	Mus musculus	279-284
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	pcmcs	65-70	immunoglobulin heavy variable V1-9	Mus musculus	194-199
24120484-3	2014	When compared to conventional aluminium-adjuvanted formulations, PCMCs modified with calcium phosphate (CaP) showed enhanced antigen-specific IgG responses and a decreased antigen-specific IgG1:IgG2a ratio, indicating the induction of a more balanced Th1/Th2 response.	calcium phosphate	85-102	immunoglobulin heavy variable V1-9	Mus musculus	194-199
24956110-5	2014	CAF01 also influenced the kinetics of both the cellular and humoral response against IPV to produce a faster, as well as a stronger, response, dominated by IgG2a, IgG2b, and IgG2c isotypes as well as IPV specific T cells secreting IFN-gamma/IL-2.	caf01	0-5	immunoglobulin heavy variable V1-9	Mus musculus	156-161
24852318-6	2014	The serum IFN-gamma and IgG2a levels significantly increased in all rDioscorin-treated mice.	rdioscorin	68-78	immunoglobulin heavy variable V1-9	Mus musculus	24-29
23790647-4	2014	When sera were analyzed for isotype distribution, antigen-specific IgG1 Ab responses were noted in mice immunized with OVA-containing polymer-unmodified liposomes, whereas immunization with OVA-containing SucPG-modified liposomes resulted in the induction of OVA-specific IgG1, IgG2a and IgG3 Ab responses.	sucpg	205-210	immunoglobulin heavy variable V1-9	Mus musculus	278-283
24950353-5	2014	Intramuscular immunisation of pVaxL9 was able to elicit the anti-L9 IgG antibody response of both IgG1 and IgG2a isotypes when compared with PBS and pVax immunised control animals.	pvax	30-34	immunoglobulin heavy variable V1-9	Mus musculus	107-112
24743699-6	2014	Sensitization of mice with CL-BLG resulted in higher levels of IgE, IgG1, and IgG2a.	cl-blg	27-33	immunoglobulin heavy variable V1-9	Mus musculus	78-83
24681230-9	2014	The serum IgG, IgG1 and IgG2a levels of the OVA-TMC group were 17.9-87.9 times higher than that of the OVA+TMC group and comparable to that of the intramuscular group.	N-trimethylaminoethylmethacrylate chitosan	48-51	immunoglobulin heavy variable V1-9	Mus musculus	24-29
24757140-10	2014	Rebamipide-treated mice showed lower circulating levels of type II collagen-specific IgG, IgG1, and IgG2a.	rebamipide	0-10	immunoglobulin heavy variable V1-9	Mus musculus	100-105
24530874-11	2014	Panduratin A decreased serum immunoglobulin (Ig) E and interleukin-4 levels but increased IgG2a and interferon-gamma levels.	panduratin A	0-12	immunoglobulin heavy variable V1-9	Mus musculus	90-95
24339889-5	2013	A DEX-based nanovaccine containing OVA and lipopolysaccharide (LPS) as a DC stimulus induced strong OVA peptide-specific CD4(+) and CD8(+) T cell proliferation both in vitro and upon systemic application in mice, as well as a robust OVA-specific humoral immune response (IgG1>IgG2a) in vivo.	based nanovaccine	6-23	immunoglobulin heavy variable V1-9	Mus musculus	279-284
24339889-5	2013	A DEX-based nanovaccine containing OVA and lipopolysaccharide (LPS) as a DC stimulus induced strong OVA peptide-specific CD4(+) and CD8(+) T cell proliferation both in vitro and upon systemic application in mice, as well as a robust OVA-specific humoral immune response (IgG1>IgG2a) in vivo.	ova	35-38	immunoglobulin heavy variable V1-9	Mus musculus	279-284
24339889-5	2013	A DEX-based nanovaccine containing OVA and lipopolysaccharide (LPS) as a DC stimulus induced strong OVA peptide-specific CD4(+) and CD8(+) T cell proliferation both in vitro and upon systemic application in mice, as well as a robust OVA-specific humoral immune response (IgG1>IgG2a) in vivo.	ova	100-103	immunoglobulin heavy variable V1-9	Mus musculus	279-284
23954198-2	2013	Based on in vitro assay, 6-O-palmitoyl Agnuside (AG-3) was further taken up for detailed in vivo activity and found to significantly enhance the production of anti OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as soluble mediators of a Th1 (IL-2, IFN-gamma)/Th2 response (IL-4) and proliferation of T lymphocyte subsets (CD4/CD8) and co stimulatory molecules CD80/CD86.	6-o-palmitoyl agnuside	25-47	immunoglobulin heavy variable V1-9	Mus musculus	211-216
24250805-5	2013	The recombinant vaccine induced specific IgG1 or IgG2a responses to CMX.	Cefmenoxime	68-71	immunoglobulin heavy variable V1-9	Mus musculus	49-54
24516267-3	2013	IgG2a/2b/3 but not IgG1 subclasses were enhanced by immunization with CpG ODN 1826 when compared with the control groups immunized with non-CpG ODN and Montanide ISA or only with Montanide ISA, suggesting a biased induction of a Th1-type response by CpG ODN.	montanide	152-161	immunoglobulin heavy variable V1-9	Mus musculus	0-5
24516267-3	2013	IgG2a/2b/3 but not IgG1 subclasses were enhanced by immunization with CpG ODN 1826 when compared with the control groups immunized with non-CpG ODN and Montanide ISA or only with Montanide ISA, suggesting a biased induction of a Th1-type response by CpG ODN.	montanide	179-188	immunoglobulin heavy variable V1-9	Mus musculus	0-5
24215486-3	2013	The serum IFN-gamma and IgG2a levels increased in all the dioscorin-treated mice.	dioscorin	58-67	immunoglobulin heavy variable V1-9	Mus musculus	24-29
24215486-6	2013	The decrease of IgE and histamine levels was concomitant with an increase in IFN-gamma and IgG2a levels and with a decrease in IL-5 levels, suggesting that dioscorins suppressed the OVA-induced allergic reactions, possibly through modulating an imbalanced Th1/Th2 immune response.	dioscorins	156-166	immunoglobulin heavy variable V1-9	Mus musculus	91-96
23306365-4	2013	Mice immunized with the fused FimH.FliC protein induced significantly higher humoral (IgG1 and IgG2a) and cellular (IFN-gamma and IL-4) immune responses than with FimH alone or FimH admixed with FliC.	fimh	30-34	immunoglobulin heavy variable V1-9	Mus musculus	95-100
23827312-7	2013	Single shot injection of PLGA-Ms 50:50/75:25-BmA/F6 produced better and stronger IgG, IgG1/IgG2a and cell-mediated immune responses than even two injections of plain BmA or F6.	bma	45-48	immunoglobulin heavy variable V1-9	Mus musculus	91-96
24812879-12	2013	The levels of IgG (0.51 +/- 0.028) and IgG2a (0.261 +/- 0.04)(on day 55) in mice immunized with pcMIC8 plus pcIL-12 were higher than pcMIC8 group (497.65 +/- 98.15) and control groups (PBS 47.18 +/- 2.73, pcDNA3.1 50.08 +/- 4.62, pcIL-12 118.15 +/- 12.73) (P < 0.05).	pcil-12	108-115	immunoglobulin heavy variable V1-9	Mus musculus	39-44
24812879-12	2013	The levels of IgG (0.51 +/- 0.028) and IgG2a (0.261 +/- 0.04)(on day 55) in mice immunized with pcMIC8 plus pcIL-12 were higher than pcMIC8 group (497.65 +/- 98.15) and control groups (PBS 47.18 +/- 2.73, pcDNA3.1 50.08 +/- 4.62, pcIL-12 118.15 +/- 12.73) (P < 0.05).	pcil	108-112	immunoglobulin heavy variable V1-9	Mus musculus	39-44
23181951-7	2013	Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice.	Curcumin	0-8	immunoglobulin heavy variable V1-9	Mus musculus	67-72
23499868-4	2013	The oral administration of OAA over a four-week period attenuated AD symptoms in terms of decreased skin lesions, epidermal thickness, the infiltration of immune cells (CD4+ cells, eosinophils, and mast cells), and serum IgE, IgG2a, and histamine levels.	Oxaloacetic Acid	27-30	immunoglobulin heavy variable V1-9	Mus musculus	226-231
23499868-6	2013	The oral administration of OAA over a three-day period attenuated ACD symptoms in terms of ear thickness, lymphocyte proliferation, and serum IgG2a levels.	Oxaloacetic Acid	27-30	immunoglobulin heavy variable V1-9	Mus musculus	142-147
23586635-7	2013	Moreover, pyriproxyfen induced higher titers of IgG2a and enhanced tumor necrosis factor-alpha and gamma-interferon responses whereas alum induced IgG1 with enhanced interleukin-4 and -10.	pyriproxyfen	10-22	immunoglobulin heavy variable V1-9	Mus musculus	48-53
23306365-4	2013	Mice immunized with the fused FimH.FliC protein induced significantly higher humoral (IgG1 and IgG2a) and cellular (IFN-gamma and IL-4) immune responses than with FimH alone or FimH admixed with FliC.	flic	35-39	immunoglobulin heavy variable V1-9	Mus musculus	95-100
22923758-9	2012	Also, treatment with 10 mg/kg of thalidomide significantly decreased immune complex accumulation, reduced the serum concentration of anti-dsDNA, IgG2a and IgG2b and inhibited nuclear translocation of NF-kappaB in kidney tissues, comparable to standard therapy for LN.	Thalidomide	33-44	immunoglobulin heavy variable V1-9	Mus musculus	145-150
23183092-8	2013	Further subcutaneous and simultaneous subcutaneous-nasal immunizations of the same mice with TERAVAC promoted IFN-gamma secretion and production of IgG2a antibodies in accordance with a Th1-type response.	teravac	93-100	immunoglobulin heavy variable V1-9	Mus musculus	148-153
23244652-8	2013	Pravastatin effectively suppressed both T(H)1- and T(H)2-mediated antibody responses, reducing serum specific IgE, IgG, IgG1, and IgG2a levels.	Pravastatin	0-11	immunoglobulin heavy variable V1-9	Mus musculus	130-135
23244652-10	2013	Similarly, atorvastatin effectively attenuated production of specific IgE, IgG1, and IgG2a antibodies.	Atorvastatin	11-23	immunoglobulin heavy variable V1-9	Mus musculus	85-90
23431260-4	2013	When sera were analyzed for isotype distribution, OVA-specific IgG1 antibody responses were noted in mice immunized with OVA-containing polymer-unmodified liposomes, whereas immunization with OVA-containing SucPG-modified liposomes resulted in the induction of OVA-specific IgG1, IgG2a, and IgG3 Ab responses.	sucpg	207-212	immunoglobulin heavy variable V1-9	Mus musculus	280-285
22800928-9	2012	Oral treatment with NSO showed significant decrease in airway hyperresponsiveness, the number of total leukocytes, macrophages and eosinophils, levels of IL-4, IL-5 and IL-13 in BALF, serum levels of total IgE, OVA-specific IgE and IgG1, and significant increase in BALF level of IFN-gamma and serum level of OVA-specific IgG2a, indicating restoration of local Th1/Th2 balance.	caraway oil	20-23	immunoglobulin heavy variable V1-9	Mus musculus	322-327
23026687-3	2012	Mice injected with pVF263 or pVF278 had a dominant immunoglobulin G2a (IgG2a) response.	pvf263	19-25	immunoglobulin heavy variable V1-9	Mus musculus	71-76
23026687-3	2012	Mice injected with pVF263 or pVF278 had a dominant immunoglobulin G2a (IgG2a) response.	pvf278	29-35	immunoglobulin heavy variable V1-9	Mus musculus	71-76
22749834-13	2012	injection, both TMC:HB and CHT:HB NPs induced higher IgG and IgG2a titers compared with alum adsorbed HB (P<0.001).	tmc	16-19	immunoglobulin heavy variable V1-9	Mus musculus	61-66
22696440-7	2012	ATRA suppressed the production of total IgG and IgG2a in splenocytes that were stimulated by LPS.	Tretinoin	0-4	immunoglobulin heavy variable V1-9	Mus musculus	48-53
22552780-6	2012	Our results showed that THC injection enhanced total IgE serum levels in response to antigen immunization even under conditions of deficient cannabinoid receptor 2 (CB2) and cannabinoid receptor 1 (CB1) activity and furthermore the increase in IgE was accompanied by a decrease in serum IgG2a.	Dronabinol	24-27	immunoglobulin heavy variable V1-9	Mus musculus	287-292
22380933-6	2012	RESULTS: Diphenylcyclopropenone enhanced antigen-specific IgG2a antibody responses as well as IL-10 cytokine production after epicutaneous immunization with ovalbumin (OVA).	diphenylcyclopropenone	9-31	immunoglobulin heavy variable V1-9	Mus musculus	58-63
23121983-3	2012	In this evaluation, c-di-GMP was a more potent activator of both humoral and Th1-like immune responses as evidenced by the robust IgG2a antibody response it induced in mice and the strong IFN-gamma, TNF-alpha and IP-10 responses, it elicited in mice and in vitro in non-human primate peripheral blood mononuclear cells.	bis(3',5')-cyclic diguanylic acid	20-28	immunoglobulin heavy variable V1-9	Mus musculus	130-135
22521849-3	2012	RESULTS: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen.	Cesium	86-88	immunoglobulin heavy variable V1-9	Mus musculus	233-238
22521849-3	2012	RESULTS: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen.	bcg-cs	89-95	immunoglobulin heavy variable V1-9	Mus musculus	233-238
22521849-3	2012	RESULTS: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen.	Cesium	93-95	immunoglobulin heavy variable V1-9	Mus musculus	233-238
22487055-10	2012	HA adjuvanted with the DC-Chol/DPPC (50:50) liposomes elicited significantly higher total IgG1 and IgG2a titers compared to the other liposomal HA formulations and non-adjuvanted HA.	3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol	23-30	immunoglobulin heavy variable V1-9	Mus musculus	99-104
22487055-10	2012	HA adjuvanted with the DC-Chol/DPPC (50:50) liposomes elicited significantly higher total IgG1 and IgG2a titers compared to the other liposomal HA formulations and non-adjuvanted HA.	1,2-Dipalmitoylphosphatidylcholine	31-35	immunoglobulin heavy variable V1-9	Mus musculus	99-104
22192846-3	2012	The Vi-DT conjugate induced high titers of anti Vi IgG with the dominant subclass being IgG1 but with considerable quantities of IgG2a, IgG2b and IgG3.	vi-dt	4-9	immunoglobulin heavy variable V1-9	Mus musculus	129-134
22035258-12	2012	IgM and IgG2a decreased in recipients receiving 200 mg/kg/day melatonin in comparison with non-treated group (P < 0.001), while this variables were significantly increased at the dose of 50 mg/kg/day (P < 0.001).	Melatonin	62-71	immunoglobulin heavy variable V1-9	Mus musculus	8-13
22423374-8	2012	Up-regulation of serum OVA-specific IgE was suppressed, whereas OVA-specific IgG1, IgG2a, and soluble IgA production were enhanced by intranasal administration of OVA-OML.	ova-oml	163-170	immunoglobulin heavy variable V1-9	Mus musculus	83-88
22068049-9	2012	The serum IgG2a levels induced by Gag p41-His-Ni-NCs (1 mug) were significantly higher than AH adjuvanted His-Gag p41.	Histidine	42-45	immunoglobulin heavy variable V1-9	Mus musculus	10-15
22068049-9	2012	The serum IgG2a levels induced by Gag p41-His-Ni-NCs (1 mug) were significantly higher than AH adjuvanted His-Gag p41.	Glycosaminoglycans	34-37	immunoglobulin heavy variable V1-9	Mus musculus	10-15
22346354-8	2012	With lipopolysaccharides or CpG oligodeoxynucleotides, LPPC dramatically enhances the IgA or IgG2A proportion of total Ig, even in hosts that have developed Th2 immunities and high IgG1 serum titers.	CPG-oligonucleotide	28-53	immunoglobulin heavy variable V1-9	Mus musculus	93-98
22123212-7	2012	When this extract was inoculated in the presence of oligodeoxinucleotides containing CpG motifs, it elicited high IgG levels, a high IgG2a/lgG1 ratio and low IgE production.	oligodeoxinucleotides	52-73	immunoglobulin heavy variable V1-9	Mus musculus	133-138
22041103-9	2012	However, administration of DR-W extract in CIA mice significantly reduced arthritic scores and serum levels of anti-CII IgG2a antibody, PGE(2), TNF-alpha, IL-1beta and IL-6 compared with those in vehicle-treated CIA mice.	dr-w	27-31	immunoglobulin heavy variable V1-9	Mus musculus	120-125
21896286-4	2011	The protective effect observed is associated with a decreased activation of peripheral CD4+ and CD8+ T lymphocytes and a decrease in the intensity of the Th1 and Th17 autoimmune response to IRBP in pristane-treated mice compared to control mice, as evidenced by the decreased production of IFNgamma and IL17 by IRBP-specific lymphocytes from lymph nodes draining the site of immunization and by the increased production of anti-IRBP IgG1 over IgG2a.	pristane	198-206	immunoglobulin heavy variable V1-9	Mus musculus	443-448
22848514-5	2012	However, imiquimod-adjuvanted vaccine elicited higher levels of serum IgG2a antibodies and increased hemagglutination inhibition titers compared to vaccine alone, suggesting enhanced induction of functional antibodies.	Imiquimod	9-18	immunoglobulin heavy variable V1-9	Mus musculus	70-75
22829914-8	2012	RESULTS: Mice exposed to ovalbumin and treated with PBS showed increased cellular infiltration in lungs and higher serum IgE, IgG1 and IgG2a levels as compared to sham mice.	Lead	52-55	immunoglobulin heavy variable V1-9	Mus musculus	135-140
21864637-7	2011	RESULTS: Prior exposure to parathion or methoxychlor induced marked increases in the following: dermatitis severity and gene expression in the ear auricle, IgE and IgG(2a) levels in serum, expression of surface antigens on helper T-cell and IgE-positive B-cell, production of Th1 and Th2 cytokines, and production of IgE in auricular lymph-node cells.	Parathion	27-36	immunoglobulin heavy variable V1-9	Mus musculus	164-170
21903769-8	2011	Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Calpha)/Bcl-X(L) GEM model, only MLN2238 alleviated osteolytic bone disease in the DP54-Luc model.	Bortezomib	26-36	immunoglobulin heavy variable V1-9	Mus musculus	102-107
22085488-11	2011	Subclasses of IgG were found to be decreased by Plumbagin treatment, IgG2a reduction seems to be more prominent.	plumbagin	48-57	immunoglobulin heavy variable V1-9	Mus musculus	69-74
21864637-7	2011	RESULTS: Prior exposure to parathion or methoxychlor induced marked increases in the following: dermatitis severity and gene expression in the ear auricle, IgE and IgG(2a) levels in serum, expression of surface antigens on helper T-cell and IgE-positive B-cell, production of Th1 and Th2 cytokines, and production of IgE in auricular lymph-node cells.	Methoxychlor	40-52	immunoglobulin heavy variable V1-9	Mus musculus	164-170
21856355-5	2011	Animal protection with recombinant StxB was conferred through both humoral and cellular immune responses as indicated by an increased antibody titre with predominance of IgG2a and IgG2b isotypes along with elevated levels of IgG1 subtype.	stxb	35-39	immunoglobulin heavy variable V1-9	Mus musculus	170-175
21604972-8	2011	GABA-treated mice had reduced collagen-reactive IgG2a, but not IgG1 antibodies, consistent with reduced Th1 help.	gamma-Aminobutyric Acid	0-4	immunoglobulin heavy variable V1-9	Mus musculus	48-53
21621644-8	2011	The specific immune response elicited by Nattectin was characterized by the production of specific antibodies IgG1 and mainly IgG2a with IL-10 and IFN-gamma synthesis by splenic cells.	nattectin	41-50	immunoglobulin heavy variable V1-9	Mus musculus	126-131
21745522-6	2011	Furthermore, FljB elicited a mixed Th1/Th2 response as shown by the presence of specific anti-OVA IgG1, IgG2a and IgG2b isotypes.	fljb	13-17	immunoglobulin heavy variable V1-9	Mus musculus	104-109
21391989-8	2011	Treatment with alpha-carba-GalCer reduced anti-CII antibody production [immunoglobulin (Ig)G and IgG2a] and CII-reactive interleukin (IL)-17 production by draining lymph node (DLN) cells, did not induce apoptosis or regulatory T cells, and significantly increased the ratio of the percentage of IFN-gamma-producing T cells to IL-17-producing T cells (Th1/Th17 ratio).	alpha-carba-galactosylceramide	15-33	immunoglobulin heavy variable V1-9	Mus musculus	97-102
21371582-5	2011	Moreover, the adjuvant effect of BOS 2000 (80 mug) on the OVA-specific IgG, IgG1, and IgG2a antibody responses to OVA in mice were more significant than those of alum.	bos 2000	33-41	immunoglobulin heavy variable V1-9	Mus musculus	86-91
21502804-6	2011	RESULTS: Administration of cimetidine to OVA-sensitized BALB/c mice promoted Th2 cytokine secretion by OVA-stimulated spleen cells in vitro and increased serum levels of OVA-specific IgE, IgG(1) and IgG(2a).	Cimetidine	27-37	immunoglobulin heavy variable V1-9	Mus musculus	199-205
21093956-9	2011	Our results indicate that including the alum-NLX mixture as an adjuvant during vaccination increased the ability of the ERL vaccine to enhance lymphocyte proliferation, shifted the immune response toward a Th1 profile and increased S. typhimurium-specific IgG, IgG2a and the ratio of IgG2a to IgG1.	alum-nlx	40-48	immunoglobulin heavy variable V1-9	Mus musculus	261-266
21093956-9	2011	Our results indicate that including the alum-NLX mixture as an adjuvant during vaccination increased the ability of the ERL vaccine to enhance lymphocyte proliferation, shifted the immune response toward a Th1 profile and increased S. typhimurium-specific IgG, IgG2a and the ratio of IgG2a to IgG1.	alum-nlx	40-48	immunoglobulin heavy variable V1-9	Mus musculus	284-289
21215307-8	2011	The levels of IgG2a type anti-CII antibody in serum were significantly reduced by treatment with higher dose of TBL-II for either 2 or 8 weeks.	tbl-ii	112-118	immunoglobulin heavy variable V1-9	Mus musculus	14-19
21346230-4	2011	Cl-amidine treatment reduced total synovial and serum citrullination, decreased clinical disease activity by ~50%, and significantly decreased IgG2a anti-mouse type II collagen Abs.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	0-10	immunoglobulin heavy variable V1-9	Mus musculus	143-148
21223974-4	2011	CTX inoculation after HSA immunisation, along with complete Freund"s adjuvant (CFA) or Aluminium hydroxide (Alum) immunisation, was able to suppress anti-HSA IgG1 and IgG2a antibody production.	Aluminum Hydroxide	87-106	immunoglobulin heavy variable V1-9	Mus musculus	167-172
21238568-8	2011	IgG1 was the predominant IgG subclass against GalXM, while immunization with Quil A as adjuvant elicited a significantly higher production of IgG2a than with Freund"s adjuvant.	Quil A	77-83	immunoglobulin heavy variable V1-9	Mus musculus	142-147
21204934-8	2011	Immunization with HP0245(EC) induced significantly higher IgG2a titers compared with SS2 bacterin, which was more effective for opsonophagocytosis.	hp0245	18-24	immunoglobulin heavy variable V1-9	Mus musculus	58-63
21423771-10	2011	Moreover, significant levels of anti-rPb27 specific IgG1, IgG2a and IgG2b isotypes were detected in the sera of mice immunized with rPb27 fluconazole treated or not.	Fluconazole	138-149	immunoglobulin heavy variable V1-9	Mus musculus	58-63
21111776-6	2011	Codelivery of the neoglycoconjugate with Quil-A, MPL, DDA alone or in combination resulted in both IgG1, IgG2a, IgG2b and IgG3 antibodies.	bis(p-chlorophenyl)acetic acid	54-57	immunoglobulin heavy variable V1-9	Mus musculus	105-110
20847539-4	2011	When starfish saponis were subcutaneously injected into mice with ovalbumin (OVA), OVA-specific IgG, especially IgG2a instead of IgG1 was produced in mouse blood, suggesting starfish saponins stimulated Th1 type immunity and they were potential sources of new adjuvants.	starfish saponis	5-21	immunoglobulin heavy variable V1-9	Mus musculus	112-117
20847539-4	2011	When starfish saponis were subcutaneously injected into mice with ovalbumin (OVA), OVA-specific IgG, especially IgG2a instead of IgG1 was produced in mouse blood, suggesting starfish saponins stimulated Th1 type immunity and they were potential sources of new adjuvants.	starfish saponins	174-191	immunoglobulin heavy variable V1-9	Mus musculus	112-117
19641087-8	2011	In addition, S-petasin (10-30 mumol/kg, s.c.) dose-dependently and significantly attenuated total and OVA-specific immunoglobulin E (IgE) levels in the serum and BALF, and enhanced the IgG(2a) level in serum of these mice.	petasin	13-22	immunoglobulin heavy variable V1-9	Mus musculus	185-191
21855057-7	2011	Our results indicate that these new isoprenoids were safe adjuvants with the ability to significantly augment immunogen-specific IgG1 and IgG2a antibody responses.	Terpenes	36-47	immunoglobulin heavy variable V1-9	Mus musculus	138-143
21431265-6	2010	Compared with Aa immunized+RD group, the level of whole IgG in Aa immunized+VAD group was significantly higher (P<0.05); The levels of IgG2a increased obviously, whereas the levels of IgG1 subtype antibody conspicuous decreased, with a significant difference (P<0.05).	VAD I protocol	76-79	immunoglobulin heavy variable V1-9	Mus musculus	138-143
21753874-5	2011	RESULTS: The serum levels of OVA-specific IgG(1) and IgG(2a) were significantly attenuated by treatment with iron oxide nanoparticles.	ferric oxide	109-119	immunoglobulin heavy variable V1-9	Mus musculus	53-59
20688035-1	2010	The acylated analogs of picroside-II were synthesized and tested for immune-adjuvant activity in the presence of weak antigen ovalbumin found to stimulate anti-OVA IgG titer, neutralizing antibody (IgG1 and IgG2a) titer as well as the production of soluble mediators of a Th1 response (IL-2 and IFN-gamma) and Th2 response (IL-4) and proliferation of T lymphocytes sub-sets (CD4/CD8).	picroside II	24-36	immunoglobulin heavy variable V1-9	Mus musculus	207-212
20937318-3	2010	These results demonstrate the ability of the non-toxic SBA-15 nanoparticles to increase the immunogenicity and repair the responsiveness of the constitutively low responder individuals inducing both the IgG2a and the IgG1 isotypes, independently of the immune cell committed and conditioning the low phenotype.	SBA-15	55-61	immunoglobulin heavy variable V1-9	Mus musculus	203-208
20875491-3	2010	In vitro, 2h-incubation with both molecules was found to increase intra-macrophage thiol content; in vivo, Ova-sensitized mice pre-treated by intraperitoneal administration of the pro-GSH molecules showed an increase in plasma anti-Ova IgG2a and IgG2b, characterizing Th1 immune response, and a decrease in IgG1, typical of the Th2 response.	Deuterium	10-12	immunoglobulin heavy variable V1-9	Mus musculus	236-241
20600405-11	2010	Moreover, TMC/CpG/OVA induced a 10 fold higher IgG2a response than TMC/TPP/OVA and enhanced the number of OVA specific IFN-gamma-producing T-cells in the spleen.	N-trimethyl chitosan chloride	10-13	immunoglobulin heavy variable V1-9	Mus musculus	47-52
20455559-4	2010	The serum titers of OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a were inhibited in mice fed ad libitum on a diet high in alpha- or beta-carotene compared to the control mice when orally sensitized to OVA.	alpha- or beta-carotene	129-152	immunoglobulin heavy variable V1-9	Mus musculus	67-72
20976163-3	2010	METHODS AND PRINCIPAL FINDINGS: Mercury treated BALB/c wt mice showed a significant but modest increase of circulating IC (CIC) from day 12 until day 18 and day 35 for IgG2a- and IgG1- CIC, respectively.	Mercury	32-39	immunoglobulin heavy variable V1-9	Mus musculus	168-173
20976163-4	2010	Mercury-treated mice lacking the trans-membrane gamma-chain of activating FcgammaRs (FcRgamma(-/-)) had significantly higher CIC levels of both IgG1-CIC and IgG2a-CIC than wt mice during the treatment course.	Mercury	0-7	immunoglobulin heavy variable V1-9	Mus musculus	157-162
20562015-6	2010	Antibodies were found to be primarily IgG1 suggesting a predominant Th2 response (IgG1/IgG2a ratio of 9).	th2	68-71	immunoglobulin heavy variable V1-9	Mus musculus	87-92
20055805-6	2010	Furthermore, a passive transfer of DSA (monoclonal IgG2a anti-H-2Kk) initiated endarteritis followed by CTA in B6.RAG1-/- mice genetically deficient in the third component of complement (RAG1-/-C3-/-).	dsa	35-38	immunoglobulin heavy variable V1-9	Mus musculus	51-56
20188213-8	2010	The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum.	Curcumin	58-66	immunoglobulin heavy variable V1-9	Mus musculus	247-252
20434553-7	2010	Results showed that coadministration of OVA with paclitaxel induced significantly higher IgG, IgG1, IgG2a, IgG2b, IgG3 and IgM responses than when OVA was used alone.	Paclitaxel	49-59	immunoglobulin heavy variable V1-9	Mus musculus	100-105
20163714-12	2010	Interestingly, periodate treatment of recombinant malaria antigen Merozoite Surface Protein-119 (MSP-119) resulted in increased detection of antigen-specific IgG2a responses in malaria-infected mice.	metaperiodate	15-24	immunoglobulin heavy variable V1-9	Mus musculus	158-163
20060944-8	2010	Of note, PCPP administration resulted in mixed Th1 and Th2 type responses (i.e., high levels of IgG2a and IgG1 as well as IFN-gamma and IL-4).	polybis(carbophenoxypropane)	9-13	immunoglobulin heavy variable V1-9	Mus musculus	96-101
21190002-6	2010	We found that in vivo administration of vitamin C by intraperitoneal injection affected isotype switching as previously reported: the titer of antigen-specific IgG1 antibody was decreased, while that of IgG2a was unaffected.	Ascorbic Acid	40-49	immunoglobulin heavy variable V1-9	Mus musculus	203-208
21190002-7	2010	Somewhat different from those observed in vivo, in vitro exposure to vitamin C slightly decreased isotype switching to IgG1 and increased isotype switching to IgG2a.	Ascorbic Acid	69-78	immunoglobulin heavy variable V1-9	Mus musculus	159-164
20193059-9	2010	Upon immunisation, offspring from mothers immunised with OVA and either PT or Al(OH)3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies compared to offspring from naive mothers.	Aluminum Hydroxide	78-85	immunoglobulin heavy variable V1-9	Mus musculus	174-179
19712713-8	2009	immunization of mice with WIV and TMC-WIV on days 0 and 21, all TMC-WIV formulations induced stronger total IgG, IgG1 and IgG2a/c responses than WIV alone, except WIV formulated with reacetylated TMC with a DAc of 54% and a DQ of 44% (TMC-RA44).	N-trimethyl chitosan chloride	34-37	immunoglobulin heavy variable V1-9	Mus musculus	122-127
19752570-9	2010	While TMA-specific IgE was induced equally in the WT and Smad3-/- mice, the concentration of TMA-specific IgG2a was significantly lower in the Smad3-/- mice.	trimellitic anhydride	93-96	immunoglobulin heavy variable V1-9	Mus musculus	106-111
19712713-8	2009	immunization of mice with WIV and TMC-WIV on days 0 and 21, all TMC-WIV formulations induced stronger total IgG, IgG1 and IgG2a/c responses than WIV alone, except WIV formulated with reacetylated TMC with a DAc of 54% and a DQ of 44% (TMC-RA44).	N-trimethyl chitosan chloride	64-67	immunoglobulin heavy variable V1-9	Mus musculus	122-127
19712713-8	2009	immunization of mice with WIV and TMC-WIV on days 0 and 21, all TMC-WIV formulations induced stronger total IgG, IgG1 and IgG2a/c responses than WIV alone, except WIV formulated with reacetylated TMC with a DAc of 54% and a DQ of 44% (TMC-RA44).	N-trimethyl chitosan chloride	64-67	immunoglobulin heavy variable V1-9	Mus musculus	122-127
19712713-8	2009	immunization of mice with WIV and TMC-WIV on days 0 and 21, all TMC-WIV formulations induced stronger total IgG, IgG1 and IgG2a/c responses than WIV alone, except WIV formulated with reacetylated TMC with a DAc of 54% and a DQ of 44% (TMC-RA44).	N-trimethyl chitosan chloride	64-67	immunoglobulin heavy variable V1-9	Mus musculus	122-127
19712713-10	2009	TMC with a DQ of 56% (TMC56) formulated with WIV at a ratio of 5:1 (w/w) resulted in significantly lower IgG2a/c:IgG1 ratios compared to TMC56 mixed in ratios of 0.2:1 and 1:1, implying a shift towards a Th2 type immune response.	N-trimethyl chitosan chloride	0-3	immunoglobulin heavy variable V1-9	Mus musculus	105-110
19900263-1	2009	BACKGROUND: The plasticizer di-(2-ethylhexyl) phthalate (DEHP) has been shown to stimulate a non-allergy related immune response with increased levels of IgG1 and IgG2a, but not IgE, after co-administration with the model allergen ovalbumin (OVA) in mice.	Diethylhexyl Phthalate	28-55	immunoglobulin heavy variable V1-9	Mus musculus	163-168
19900263-1	2009	BACKGROUND: The plasticizer di-(2-ethylhexyl) phthalate (DEHP) has been shown to stimulate a non-allergy related immune response with increased levels of IgG1 and IgG2a, but not IgE, after co-administration with the model allergen ovalbumin (OVA) in mice.	Diethylhexyl Phthalate	57-61	immunoglobulin heavy variable V1-9	Mus musculus	163-168
19900263-3	2009	As DEHP selectively promote formations of IgG1 and IgG2a without stimulating the IgE response, it was hypothesized that DEHP may suppress an established IgE mediated allergic response.	Diethylhexyl Phthalate	3-7	immunoglobulin heavy variable V1-9	Mus musculus	51-56
19738077-9	2009	Engineering Flt3L to be constitutively secreted and attaching an IgG2a tail yielded a B16 vaccine that, when combined with CTLA-4 blockade, prevented the outgrowth of significantly more 5-day implanted B16-BL6 tumors than did Gvax.	gvax	226-230	immunoglobulin heavy variable V1-9	Mus musculus	65-70
19751176-5	2009	Immunization with rHBsAg ISCOMs resulted in upregulation of specific cellular (IFN-gamma and IL-2) as well as IgG response (IgG2a isotype biased) humoral response in Balb/c mice.	rhbsag	18-24	immunoglobulin heavy variable V1-9	Mus musculus	124-129
19384465-7	2009	Monophosphoryl lipid A did not modify the cytokines production but increased the anti-luciferase IgG2a titres.	monophosphoryl	0-14	immunoglobulin heavy variable V1-9	Mus musculus	97-102
19794984-8	2009	PE-CpG-dG(6) only increased ovalbumin-specific IgG2a.	pe-cpg-dg	0-9	immunoglobulin heavy variable V1-9	Mus musculus	47-52
19498044-12	2009	Immunization with OVA/rLZ-8 showed that the anti-OVA IgG2a, IFN-gamma, and IL-2 were increased significantly compared with OVA alone in BALB/c mice.	rlz-8	22-27	immunoglobulin heavy variable V1-9	Mus musculus	53-58
19549606-5	2009	Strikingly, we find that the combination of LMS and alum adjuvant synergistically enhances immunogenicity of rHBsAg and leads to a robust cell-mediated response demonstrated by the higher level of IgG2a/IgG1, T cell proliferation, and importantly, a high level of antigen-specific CTL and IFN-gamma production within these activated CD8(+) T cells.	alum adjuvant	52-65	immunoglobulin heavy variable V1-9	Mus musculus	197-202
19645570-5	2009	Exposure of mice to 5 or 50 ppm toluene resulted in increased immunoglobulin (Ig) G1 and decreased IgG2a and IgE antibodies in the plasma; significantly decreased T-bet, GATA-3, and Foxp3 mRNA in the spleen; and a tendency toward decreased interferon (IFN)-gamma mRNA in spleen.	Toluene	32-39	immunoglobulin heavy variable V1-9	Mus musculus	99-104
19645570-6	2009	Exposure of mice to low-level toluene together with PGN stimulation resulted in decreased IgG1 as well as IgG2a antibodies in the plasma and Foxp3 mRNA in spleen as compared with control or PGN-treated mice.	Toluene	30-37	immunoglobulin heavy variable V1-9	Mus musculus	106-111
19384465-7	2009	Monophosphoryl lipid A did not modify the cytokines production but increased the anti-luciferase IgG2a titres.	Lipid A	15-22	immunoglobulin heavy variable V1-9	Mus musculus	97-102
18985430-3	2009	The phoP-phoQ null mutant elicited much weaker IgG antibody response to whole cell sonicated (WCS) antigen, in particular that of IgG2a isotype.	phop-phoq	4-13	immunoglobulin heavy variable V1-9	Mus musculus	130-135
19303462-6	2009	A significant increase in anti-SRBC IgG forming cells, serum levels of anti-KLH as well as anti-DNP IgG and IgG2a was observed after GlcNAc8 administration in C57BL/6 mice.	N-acetylchitooctaose	133-140	immunoglobulin heavy variable V1-9	Mus musculus	108-113
19336921-5	2009	In M-16V-administered mice, there was a significant decrease in the serum OVA-specific IgG1/IgG2a ratio.	Acoramidis	5-8	immunoglobulin heavy variable V1-9	Mus musculus	92-97
18771904-5	2009	In parallel with the differential modulation of the production of IgG(2a) and IgE, treatment of OVA-sensitized mice with silibinin markedly increased and decreased the production of IFN-gamma and IL-4, respectively, by splenocytes cultured in the presence of OVA.	Silybin	121-130	immunoglobulin heavy variable V1-9	Mus musculus	66-72
18805484-5	2009	Control loperamide-loaded HSA nanoparticles with IgG2a antibodies yielded only marginal effects.	Loperamide	8-18	immunoglobulin heavy variable V1-9	Mus musculus	49-54
19479860-8	2009	High-dose DMPA treatment resulted in a reduction of total serum IgG and IgG2a anti-dsDNA antibody levels, whereas IgG1 anti-dsDNA antibody levels were modestly increased.	Medroxyprogesterone Acetate	10-14	immunoglobulin heavy variable V1-9	Mus musculus	72-77
19479860-9	2009	High-dose DMPA reduced glomerular accumulation of IgG1, IgG2a, IgG3, and complement, while low-dose DMPA decreased glomerular IgG2a and IgG3 levels compared with vehicle treatment.	Medroxyprogesterone Acetate	10-14	immunoglobulin heavy variable V1-9	Mus musculus	56-61
19479860-9	2009	High-dose DMPA reduced glomerular accumulation of IgG1, IgG2a, IgG3, and complement, while low-dose DMPA decreased glomerular IgG2a and IgG3 levels compared with vehicle treatment.	Medroxyprogesterone Acetate	100-104	immunoglobulin heavy variable V1-9	Mus musculus	126-131
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Proline	33-40	immunoglobulin heavy variable V1-9	Mus musculus	179-184
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Arginine	70-78	immunoglobulin heavy variable V1-9	Mus musculus	179-184
19076835-7	2009	More importantly, in response to mercury a large numbers of ICR (88%), NMRI (96%) and Black Swiss (100%) mice produced different levels of IgG1 and IgG2a ANolA (a characteristic which is linked strictly to the H-2 genes).	Mercury	33-40	immunoglobulin heavy variable V1-9	Mus musculus	148-153
19076835-8	2009	Similarly, but at lower magnitudes, treatment with silver also induced the production of IgG1 and IgG2a ANolA in 60% of ICR, 75% of NMRI and 100% of Black Swiss mice.	Silver	51-57	immunoglobulin heavy variable V1-9	Mus musculus	98-103
18706494-7	2008	The results demonstrated that methamphetamine and/or diazepam significantly attenuated the production of OVA-specific IgM, IgG(1) and IgG(2a).	Methamphetamine	30-45	immunoglobulin heavy variable V1-9	Mus musculus	134-140
18973783-5	2009	Results indicated that when co-administered with a mixture of oil and GSLS, FMDV antigen induced significantly higher IgG titer and IgG1, IgG2a, IgG2b and IgG3 responses, production of IFN-gamma (Th1 cytokine) and IL-5 (Th2 cytokine) by splenocytes, as well as T and B lymphocyte proliferation in response to Con A and LPS than when FMDV antigen was used alone or mixed with either GSLS or oil.	Oils	62-65	immunoglobulin heavy variable V1-9	Mus musculus	138-143
18973783-5	2009	Results indicated that when co-administered with a mixture of oil and GSLS, FMDV antigen induced significantly higher IgG titer and IgG1, IgG2a, IgG2b and IgG3 responses, production of IFN-gamma (Th1 cytokine) and IL-5 (Th2 cytokine) by splenocytes, as well as T and B lymphocyte proliferation in response to Con A and LPS than when FMDV antigen was used alone or mixed with either GSLS or oil.	gsls	70-74	immunoglobulin heavy variable V1-9	Mus musculus	138-143
19571489-6	2009	Exposure of mice to 50 ppm toluene enhanced total immunoglobulin (Ig) G2a (Th1-dependent) level in plasma.	Toluene	27-34	immunoglobulin heavy variable V1-9	Mus musculus	50-73
19050295-4	2008	The relative nephritogenicity of anti-trinitrophenol switch variant mAbs was then explored and shown to be IgG2a > IgG2b, with no disease caused by IgG1.	picric acid	38-52	immunoglobulin heavy variable V1-9	Mus musculus	107-112
18930100-9	2008	The protective antiserum contained high titers of SCHU S4-specific IgG2a, indicating that a strong Th1 response was induced following levofloxacin treatment.	Levofloxacin	134-146	immunoglobulin heavy variable V1-9	Mus musculus	67-72
18706494-7	2008	The results demonstrated that methamphetamine and/or diazepam significantly attenuated the production of OVA-specific IgM, IgG(1) and IgG(2a).	Diazepam	53-61	immunoglobulin heavy variable V1-9	Mus musculus	134-140
18614331-12	2008	The CD1 mice inoculated with a non-lethal dose of the ctpA mutant produced specific serum immunoglobulins IgG1 and IgG2a and were partially protected against challenge with wild type B. mallei ATCC 23344.	4-((1,4,8,11-tetraazacyclotetradec-1-yl)methyl)benzoic acid	54-58	immunoglobulin heavy variable V1-9	Mus musculus	115-120
19157096-5	2008	RESULTS: The results of SDS-PAGE showed that the new protein carrier was obtained, which It could enter PC-3 cells with DNA in vitro and induce the mouse immune system to produce IgG1 and IgG2alpha simultaneously.	Sodium Dodecyl Sulfate	24-27	immunoglobulin heavy variable V1-9	Mus musculus	188-197
18302727-8	2008	RESULTS: Alcohol intake decreased the level of OVA-specific IgG2a in a dose-dependent manner, whereas high levels of alcohol markedly increased the level of total IgE, but not OVA-specific IgE.	Alcohols	9-16	immunoglobulin heavy variable V1-9	Mus musculus	60-65
18422871-9	2008	Interestingly, the plasmid containing GPI anchor signal sequence produced significantly higher levels of IgG2a and IgG2b than the plasmid that lacks GPI signal sequence.	Glycosylphosphatidylinositols	38-41	immunoglobulin heavy variable V1-9	Mus musculus	105-110
18356340-5	2008	Both reovirus-specific serum IgA and IgG(2a) were comparably induced in mice fed control or DHA diets.	Docosahexaenoic Acids	92-95	immunoglobulin heavy variable V1-9	Mus musculus	37-43
18081882-7	2008	Clemastine increased IgE production while decreasing IgG2a production against bee venom.	Clemastine	0-10	immunoglobulin heavy variable V1-9	Mus musculus	53-58
17980417-11	2008	Total serum IgE, IgG(1), and IgG(2a) remained significantly elevated in TDI-sensitized mice until 90 days after dermal sensitization.	Toluene 2,4-Diisocyanate	72-75	immunoglobulin heavy variable V1-9	Mus musculus	29-35
18096152-7	2008	In addition, when administered from the day prior to sensitization to the end of challenge, fenofibrate (15 mg/day) triggered switching of the immune response to allergen towards a Th1 profile, as evidenced by an increase in IgG2a levels, a reduction in IL(interleukin)-4 and IL-5 together with an increase in interferon-gamma, and a decrease in Gata-3/T-bet expression ratio.	Fenofibrate	92-103	immunoglobulin heavy variable V1-9	Mus musculus	225-230
17535305-3	2007	Administration of the mAbs KSAb1 (IgG2b) or KSAb2 (IgG2a), which have similar stimulating properties but different TSH-binding blocking activity, resulted in significantly elevated serum thyroxine (T(4)) levels and thyroid hyperplasia.	Thyrotropin	115-118	immunoglobulin heavy variable V1-9	Mus musculus	51-56
18025183-1	2007	We have previously shown that rheumatoid factors produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity.	ammonium ferrous sulfate	61-64	immunoglobulin heavy variable V1-9	Mus musculus	123-128
17535305-3	2007	Administration of the mAbs KSAb1 (IgG2b) or KSAb2 (IgG2a), which have similar stimulating properties but different TSH-binding blocking activity, resulted in significantly elevated serum thyroxine (T(4)) levels and thyroid hyperplasia.	Thyroxine	187-196	immunoglobulin heavy variable V1-9	Mus musculus	51-56
17582479-7	2007	In the treatment model IMO-treated mice showed decreased IgE, IL-5, and IL-13 levels and increased IgG2a and IFN-gamma levels in the serum, intestines, and spleen cells compared with PBS-treated mice.	6-o-phosphoryl inosine monophosphate	23-26	immunoglobulin heavy variable V1-9	Mus musculus	99-104
18163337-6	2007	Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI.	th2	78-81	immunoglobulin heavy variable V1-9	Mus musculus	141-146
17686554-3	2007	Immunization with rSurA in adjuvant induced a vigorous immunoglobulin G (IgG) response, with higher IgG2a than IgG1 titers.	rsura	18-23	immunoglobulin heavy variable V1-9	Mus musculus	100-105
17827700-3	2007	Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-gamma secretion and increases in IgA and IgG2a production.Additionally, it was found that orally administered BPA increased antigen-specific IFN-gamma production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells.	bisphenol A	13-16	immunoglobulin heavy variable V1-9	Mus musculus	121-126
17827700-3	2007	Administered BPA moderately reduced interleukin (IL)-2, 4, and interferon (IFN)-gamma secretion and increases in IgA and IgG2a production.Additionally, it was found that orally administered BPA increased antigen-specific IFN-gamma production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells.	bisphenol A	190-193	immunoglobulin heavy variable V1-9	Mus musculus	121-126
17675803-3	2007	The results showed that the mice injected with SGEPL produced a significant portion of anti-OVA antibody subclass IgG2a in the sera and suppressed interleukin (IL)-4 and IL-5, but enhanced IL-12 and interferon-gamma (IFN-gamma) from the spleen cells.	sgepl	47-52	immunoglobulin heavy variable V1-9	Mus musculus	114-119
17515845-7	2007	Moreover, after low dose OVA administration, serum OVA-specific IgG1 and IgG2a levels were higher in the BPA-exposed offspring than in nonexposed ones.	bisphenol A	105-108	immunoglobulin heavy variable V1-9	Mus musculus	73-78
17466906-12	2007	The IgG1/IgG2a ratio within the anti-HBsAg antibodies was higher in the mice immunised with HBsAg plus beta-glu6 than receiving HBsAg alone or mice administered HBsAg with Freund"s adjuvant, indicating a shift towards a Th2-biased anti-inflammatory protective antibody response.	beta-glu6	103-112	immunoglobulin heavy variable V1-9	Mus musculus	9-14
17466911-4	2007	The serum level of OVA-specific IgM was significantly attenuated by a high dose of CBD (20 mg/kg), and OVA-specific IgG(1) and IgG(2a) by all 3 doses of CBD.	Cannabidiol	153-156	immunoglobulin heavy variable V1-9	Mus musculus	127-133
17195015-5	2007	The suppression of dermatitis by PG102 was accompanied by a decrease in the plasma level of IgE, IgG1, and IL-4 and also by an increase in that of IgG2a and IL-12.	pg102	33-38	immunoglobulin heavy variable V1-9	Mus musculus	147-152
17469145-10	2007	T cell production of interferon-gamma and interleukin-10 and B cell release of IgG2a were reduced by treatment with seliciclib.	Roscovitine	116-126	immunoglobulin heavy variable V1-9	Mus musculus	79-84
17336162-2	2007	Herein we found that ovariectomized NZB/NZW F1 mice treated with propyl pyrazole triol (ERalpha-selective agonist) had significantly shorter survival, earlier development of albuminuria, higher serum concentrations of total IgG and prolactin, increased serum levels of anti-DNA IgG3, IgG2a and IgG2b and decreased anti-DNA IgG1 level compared to vehicle controls.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	65-86	immunoglobulin heavy variable V1-9	Mus musculus	284-289
17440622-5	2007	Treated mice show reduced CII-driven T cell proliferation and IFN-gamma production, as well as significantly lower levels of CII-specific IgG2a serum antibodies.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	125-128	immunoglobulin heavy variable V1-9	Mus musculus	138-143
17566144-0	2007	Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice.	Diosgenin	0-9	immunoglobulin heavy variable V1-9	Mus musculus	60-65
17566144-3	2007	The production of OVA-specific serum IgG2a was significantly enhanced by diosgenin treatment, whereas total IgE and OVA-specific IgG1, IgG2a and IgM were unaffected.	Diosgenin	73-82	immunoglobulin heavy variable V1-9	Mus musculus	37-42
17566144-4	2007	In parallel with the enhancement of IgG2a, OVA-induced IFN-gamma secretion and mRNA expression were markedly elevated in splenocytes of diosgenin-treated mice, whereas IL-4 expression was unaltered.	Diosgenin	136-145	immunoglobulin heavy variable V1-9	Mus musculus	36-41
17566144-8	2007	The present study provides evidence to show that intake of diosgenin modulates certain aspects of acquired immunity, including the enhancement of antigen-specific IgG2a and IFN-gamma expression, which may be mediated through the up-regulation of Th1 differentiation.	Diosgenin	59-68	immunoglobulin heavy variable V1-9	Mus musculus	163-168
17460944-8	2007	However, the ratio of serum total IgE to IgG2a levels was significantly increased in erythromycin-treated mice relative to that found either in LFK-treated mice or in erythromycin-treated mice with LFK supplementation.	Erythromycin	85-97	immunoglobulin heavy variable V1-9	Mus musculus	41-46
18958721-9	2007	In contrast, the serum levels of anti-histone autoantibodies and total IgG(2a) were significantly elevated in the TCE-exposed offspring.	Trichloroethylene	114-117	immunoglobulin heavy variable V1-9	Mus musculus	71-77
17079263-7	2007	Also, NQ exhibited adjuvant activity for the antigen-specific production of IgG(1) and IgG(2a).	Naphthoquinones	6-8	immunoglobulin heavy variable V1-9	Mus musculus	87-93
17140708-3	2007	Both PCEP and PCPP significantly enhanced serum antigen-specific total IgG, IgG1 and IgG2a antibody titers, and these responses were highest in PCEP-immunized mice.	polybis(carbophenoxypropane)	14-18	immunoglobulin heavy variable V1-9	Mus musculus	85-90
17365015-5	2007	Treatment with rolipram was followed by inhibition of the early phase of AIA associated with downregulation of both OVA-specific splenocyte proliferation and decreases of IFN-gamma released from the spleen cells but no decreases of the amount of IL-10, or levels of anti-OVA IgG, IgG2a, and IgG1.	Rolipram	15-23	immunoglobulin heavy variable V1-9	Mus musculus	280-285
17336338-6	2007	Confirmation of Th1 polarization was obtained from augmented levels of IgG2a over IgG1 in the blood sera of AGB treated groups.	norarginine	108-111	immunoglobulin heavy variable V1-9	Mus musculus	71-76
17461447-16	2007	The ratio of anti- H pylori IgG2a/IgG1 in serum was significantly lower in the groups with chitosan as an adjuvant than in the groups with CT as an adjuvant or without adjuvant (P < 0.01).	Chitosan	91-99	immunoglobulin heavy variable V1-9	Mus musculus	28-33
16900204-6	2006	Most significantly, polyI:C-treated (B6.Nba2 x NZW)F1 mice, but not (B6 x NZW)F1 or parental strains, developed lupus-like nephritis in an accelerated fashion, which was dependent on IFNalpha/beta and associated with elevated deposition of total IgG, IgG2a and complement factor C3 in the glomerular capillary walls.	Poly I-C	20-27	immunoglobulin heavy variable V1-9	Mus musculus	251-281
17164791-5	2007	Upon intramuscular injection into mice, the vector that both displayed and expressed CS induced higher anti-CS antibody titers (of the immunoglobulin (IgG)1 and IgG2a type) and a higher frequency of interferon-gamma-producing T cells specific to CS, than the vectors which either only displayed or only expressed CS.	Cesium	85-87	immunoglobulin heavy variable V1-9	Mus musculus	161-166
18928058-6	2007	Moreover, treatment with TT+CS resulted in a lower IgG1/IgG2a ratio and a stronger in vitro IFN-gamma synthesis by splenocytes and T cells cocultured with macrophages.	tt+cs	25-30	immunoglobulin heavy variable V1-9	Mus musculus	56-61
17082623-6	2006	Moreover, DPDC-treated mice displayed significantly higher levels of MoPn-specific IgG2a production and delayed-type hypersensitivity responses compared with SPDC-treated mice.	dpdc	10-14	immunoglobulin heavy variable V1-9	Mus musculus	83-88
16907919-10	2006	Abrogation of the allergic response with complete suppression of anaphylactic symptoms and lower serum histamine levels was observed in the desensitized group by GMFA, accompanied by significantly reduced ovomucoid-specific IgE and IgG1 levels and enhanced specific IgG and IgG2a levels.	gmfa	162-166	immunoglobulin heavy variable V1-9	Mus musculus	274-279
16815494-8	2006	Levels of OVA-specific IgG2a and IgG2b production and interleukin-4 production in response to OVA were not significantly different but tended to decrease in genistein-treated mice.	Genistein	157-166	immunoglobulin heavy variable V1-9	Mus musculus	23-28
16515817-5	2006	Higher and increasing ratios of IgG2a/IgG1 were seen in mice which received plasmids in combination with Den123.	den123	105-111	immunoglobulin heavy variable V1-9	Mus musculus	32-37
16755040-9	2006	Furthermore, levels of anti-CII antibody, especially of the IgG2a subclass, in sera from mice treated with CII plus OX-CA were significantly low.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	28-31	immunoglobulin heavy variable V1-9	Mus musculus	60-65
16751983-12	2006	Susceptibility to EAU is related to the intrinsic capacity to mount higher inflammatory reactions and increased production of anti-IRBP IgG2a isotype is not necessarily a marker of this immunologic profile.	Water	18-21	immunoglobulin heavy variable V1-9	Mus musculus	136-141
16755040-9	2006	Furthermore, levels of anti-CII antibody, especially of the IgG2a subclass, in sera from mice treated with CII plus OX-CA were significantly low.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	107-110	immunoglobulin heavy variable V1-9	Mus musculus	60-65
16755040-9	2006	Furthermore, levels of anti-CII antibody, especially of the IgG2a subclass, in sera from mice treated with CII plus OX-CA were significantly low.	ox-ca	116-121	immunoglobulin heavy variable V1-9	Mus musculus	60-65
16637684-13	2006	Suppression of OVA-specific IgG1 and an increase of OVA-IgG2a were observed in mice fed saponin.	Saponins	88-95	immunoglobulin heavy variable V1-9	Mus musculus	56-61
16494843-9	2006	The increase in IgG2a levels in GMFA together with the decline of IgE and IgG1 points to a shift from a Th2 response to a Th1 dominated response.	gmfa	32-36	immunoglobulin heavy variable V1-9	Mus musculus	16-21
16494977-2	2006	In animal immunogenicity studies, we found that most anti-rN protein antibodies were IgG2a in BALB/c mice vaccinated with rN emulsified in Montanide ISA-51 containing the synthetic oligodeoxynucleotide, CpG.	montanide ISA 51	139-155	immunoglobulin heavy variable V1-9	Mus musculus	85-90
16823915-5	2006	The predominant subclass was IgG1 although higher levels of IgG2a were observed as the carbon chain length of AGs increased.	Carbon	87-93	immunoglobulin heavy variable V1-9	Mus musculus	60-65
16823924-5	2006	Mice immunized with Cochleate or PL via intranasal or oral route-induced anti PL IgG and IgG2a antibody responses in their sera and vaginal fluids.	cochleate	20-29	immunoglobulin heavy variable V1-9	Mus musculus	89-94
16309812-11	2006	n-Hexadecane induced hypergammaglobulinemia (IgG1, IgG2a), antinuclear (titer>1:160, 67%) and -cytoplasmic antibodies (58%) and autoantibodies to nRNP/Sm (25%), Su (33%), ssDNA (83%), and chromatin (100%).	n-hexadecane	0-12	immunoglobulin heavy variable V1-9	Mus musculus	51-56
16326921-6	2006	Interleukin (IL)-2 and interferon (IFN)-gamma as well as anti-OVA IgG2a and IgG3, indicators of Th1 immune responses, were markedly decreased in mice treated with DZ2002, whereas IL-4 and anti-OVA IgG1, indicators of Th2 immune responses, were only mildly suppressed.	methyl 4-(adenin-9-yl)-2-hydroxybutanoate	163-169	immunoglobulin heavy variable V1-9	Mus musculus	66-71
16537998-5	2006	In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-gamma (P<0.05) and IL-12 (P<0.05) with an intact IL-4.	bisphenol A	36-39	immunoglobulin heavy variable V1-9	Mus musculus	108-113
16280381-3	2006	Lead significantly enhanced serum IgG1 anti-keyhole limpet hemocyanin (KLH) levels in WT mice compared to the controls; Pb also increased serum IgG2a anti-KLH levels, but the IgG1:IgG2a ratio was greater with Pb.	Lead	120-122	immunoglobulin heavy variable V1-9	Mus musculus	144-149
16280381-6	2006	Surprisingly, Pb significantly enhanced IgG1 and IgG2a anti-KLH levels in the KO mice.	Lead	14-16	immunoglobulin heavy variable V1-9	Mus musculus	49-54
16006019-6	2005	Administration of DPT vaccine with CpG-ODN (DPT-alum/ODN) to mice significantly reduced the total IgE levels and increased the anti-PT specific IgG2a titer in serum, in comparison with ordinary DPT vaccine (DPT-alum).	dpt	18-21	immunoglobulin heavy variable V1-9	Mus musculus	144-149
16280381-6	2006	Surprisingly, Pb significantly enhanced IgG1 and IgG2a anti-KLH levels in the KO mice.	CHEMBL2385481	60-63	immunoglobulin heavy variable V1-9	Mus musculus	49-54
16280381-7	2006	However, for these mice, unlike the WT mice, Pb caused a greater percentage change in IgG2a than in IgG1 anti-KLH, indicating less skewing toward type-2 immunoglobulins.	Lead	45-47	immunoglobulin heavy variable V1-9	Mus musculus	86-91
16040168-5	2005	The IgG2a/IgG1 ratio was lower in mice treated with ATRA.	Tretinoin	52-56	immunoglobulin heavy variable V1-9	Mus musculus	4-9
16237074-3	2005	Thus, in contrast to the mixed IgG1-IgG2a response observed in control animals, ES-62-treated mice exhibited a Th2-biased IgG Ab response as evidenced by stable enhancement of anti-OVA IgG1 production and a profound inhibition of anti-OVA IgG2a.	es-62	80-85	immunoglobulin heavy variable V1-9	Mus musculus	239-244
16200624-8	2005	Exacerbation of CIA was associated with an enhanced Th1-type response, including increased type 1 cytokine production, an enhanced DTH response, and elevated production of CII-specific IgG2a antibodies.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	172-175	immunoglobulin heavy variable V1-9	Mus musculus	185-190
18958679-6	2005	Exposure to OAA and oleic acid caused significant increases in IgG, IgG(1), IgG(2a), and IgG(2b) levels as compared to aniline and control groups, whereas IgG(3) value increased only in OAA-treated mice.	oleoylanilide	12-15	immunoglobulin heavy variable V1-9	Mus musculus	76-82
18958679-6	2005	Exposure to OAA and oleic acid caused significant increases in IgG, IgG(1), IgG(2a), and IgG(2b) levels as compared to aniline and control groups, whereas IgG(3) value increased only in OAA-treated mice.	Oleic Acid	20-30	immunoglobulin heavy variable V1-9	Mus musculus	76-82
16148116-7	2005	In contrast, the type 1 response (IFN-gamma, TNF-alpha, IgG2a) to TNP-OVA induced by the diabetogen streptozotocin still developed in the absence of CD80/CD86 costimulatory signaling.	Streptozocin	100-114	immunoglobulin heavy variable V1-9	Mus musculus	56-61
16253125-8	2005	Treatment of the CFA and IFA groups with rolipram significantly inhibited the production of the Th1 antibody anti-OVA immunoglobulin G2a (IgG2a), and the drug enhanced Th2 cell-dependent anti-OVA IgE production.	Rolipram	41-49	immunoglobulin heavy variable V1-9	Mus musculus	138-143
15967044-4	2005	We examined how polystyrene particles (PSP) affected the IgE and IgG2a responses against the model allergen ovalbumin (OVA), after subcutaneous injection into the footpad of BALB/cA, BALB/cJ, NIH and C3H/HeN mice, Further, ex vivo IL-4, IFN-gamma and IL-10 cytokine secretion by Con A-stimulated cells from the draining popliteal lymph node (PLN) five days after injection of OVA and PSP separately or in combination was determined.	Polystyrenes	16-27	immunoglobulin heavy variable V1-9	Mus musculus	65-70
15950742-2	2005	A single intraperitoneal or subcutaneous injection of Taenia glycans altered the Th-1/Th-2 balance in experimentally infected mice as determined by Western blot analysis of IgG 1 and IgG 2a antibodies to L. mexicana antigens.	taenia glycans	54-68	immunoglobulin heavy variable V1-9	Mus musculus	183-189
15802965-6	2005	IgG1/IgG2a isotype profiles supported increased production of EPs in pcJEME-inoculated mice by needle-free injection and an adjuvant effect of the vector on immunogenicity of JEVAX.	eps	62-65	immunoglobulin heavy variable V1-9	Mus musculus	5-10
15922967-2	2005	Naive mice vaccinated with the amidine/allergen complex developed a Th1-biased immune response characterized by the absence of specific IgE, the production of specific IgG2a, and the presence of IFN-gamma in splenocyte cultures.	Amidines	31-38	immunoglobulin heavy variable V1-9	Mus musculus	168-173
15720444-4	2005	While mercury administered prior to the induction phase of CIA exerted little, if any, influence, administration of mercury during the induction phase and following onset aggravated the symptoms of this disease and increased the serum levels of IgE and IgG2a antibodies directed against collagen type II (CII).	Mercury	116-123	immunoglobulin heavy variable V1-9	Mus musculus	253-258
15639644-4	2005	As in conventional mice, pristane-treated germ-free mice developed peritoneal granulomas and hypergammaglobulinemia with increased IgG2a/IgG1 ratios.	pristane	25-33	immunoglobulin heavy variable V1-9	Mus musculus	131-136
15620480-6	2005	Mouse vaccination with either CP05 or QS21 in combination with the fucose-mannose ligand (FML) antigen of Leishmania donovani showed anti-FML responses, significantly enhanced over the saponin and saline controls, in IgM, IgG, IgG1, IgG2a, IgG2b and IgG3.	Fucose	67-73	immunoglobulin heavy variable V1-9	Mus musculus	233-238
15589047-3	2005	The serum anti-dsDNA IgG2a levels were increased significantly by stress at 19 weeks of age, which was simultaneously accompanied by inhibition of the serum corticosterone elevation.	Corticosterone	157-171	immunoglobulin heavy variable V1-9	Mus musculus	21-26
15479282-8	2004	In addition, when the sensitized mice were boosted with the same allergens 14 days after last treatment of OVA-DT, the mice showed to increase the production of OVA-specific IgG2a/IgG3 and decreased that of OVA-specific IgE.	ova-dt	107-113	immunoglobulin heavy variable V1-9	Mus musculus	174-179
15531043-3	2004	Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity.	Gadolinium	21-23	immunoglobulin heavy variable V1-9	Mus musculus	208-213
15531043-3	2004	Co-administration of gD with IL-12 resulted in gD-specific antibody subclass switching from predominantly IgG1 observed in mice immunized with either gD or gD/AlPO4 to a more balanced combination of IgG1 and IgG2a, and enhanced virus neutralizing activity.	Gadolinium	47-49	immunoglobulin heavy variable V1-9	Mus musculus	208-213
15379788-0	2004	Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice.	Benzalkonium Compounds	19-40	immunoglobulin heavy variable V1-9	Mus musculus	80-85
15142267-5	2004	Mice that had been fed with CII also exhibited increased serum IgG1 and decreased serum IgG2a as compared with nontolerized CIA animals.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	28-31	immunoglobulin heavy variable V1-9	Mus musculus	88-93
15246616-7	2004	The ester induced both IgG1 and IgG2a antibody responses in mice in a dispersed form without base oil.	Esters	4-9	immunoglobulin heavy variable V1-9	Mus musculus	32-37
15256726-4	2004	On the other hand, the OVA-specific IgG2a titer in mice fed beta-carotene was significantly greater than those of control mice.	beta Carotene	60-73	immunoglobulin heavy variable V1-9	Mus musculus	36-41
15196218-7	2004	Both Th1 responses (including anti-HEL IgG2a and IFN-gamma production) and Th2 responses (including anti-HEL IgG1 and IL-4 production) were augmented by prenatal exposure to BPA, although the augmentation of Th1 responses appeared to be greater than that of Th2 responses.	bisphenol A	174-177	immunoglobulin heavy variable V1-9	Mus musculus	39-44
14718649-9	2004	At 3 months, pristane and IFA induced mainly IgG2a, squalene IgG1, and MOs IgG3 and IgM in sera.	pristane	13-21	immunoglobulin heavy variable V1-9	Mus musculus	45-50
15030580-1	2004	Severe hypercholesterolaemia is associated with decreased levels of immunoglobulin G2a (IgG2a) antibodies [T-helper 1 (Th1) response] to modified malondialdehyde-modified low-density lipoprotein (MDA-LDL) and increased levels of Th2-dependent IgG1 antibodies in apolipoprotein E-deficient (apoE(-/-)) mice.	Malondialdehyde	146-161	immunoglobulin heavy variable V1-9	Mus musculus	88-93
14736497-10	2004	The total serum concentration of IgE, IgG1, and IgG2a showed a significant dose-related increase in thimerosal-treated mice, with a LOAEL of 5 mg thimerosal/l for IgG1 and IgE, and 20 mg thimerosal/l for IgG2a.	Thimerosal	100-110	immunoglobulin heavy variable V1-9	Mus musculus	48-53
14736497-10	2004	The total serum concentration of IgE, IgG1, and IgG2a showed a significant dose-related increase in thimerosal-treated mice, with a LOAEL of 5 mg thimerosal/l for IgG1 and IgE, and 20 mg thimerosal/l for IgG2a.	Thimerosal	100-110	immunoglobulin heavy variable V1-9	Mus musculus	204-209
14736497-10	2004	The total serum concentration of IgE, IgG1, and IgG2a showed a significant dose-related increase in thimerosal-treated mice, with a LOAEL of 5 mg thimerosal/l for IgG1 and IgE, and 20 mg thimerosal/l for IgG2a.	Thimerosal	146-156	immunoglobulin heavy variable V1-9	Mus musculus	48-53
14736497-10	2004	The total serum concentration of IgE, IgG1, and IgG2a showed a significant dose-related increase in thimerosal-treated mice, with a LOAEL of 5 mg thimerosal/l for IgG1 and IgE, and 20 mg thimerosal/l for IgG2a.	Thimerosal	146-156	immunoglobulin heavy variable V1-9	Mus musculus	48-53
15183463-7	2004	Only DDA had a statistically significant adjuvant effect on IgG2a antibody levels.	dimethyldioctadecylammonium	5-8	immunoglobulin heavy variable V1-9	Mus musculus	60-65
14764696-3	2004	Thus, administration of Ag in the Th1-selective adjuvant CFA to prefed animals resulted in significant inhibition of IgG2a, IL-2, and IFN-gamma responses, whereas IL-5 responses were increased.	3-chloro-4-fluoroaniline	57-60	immunoglobulin heavy variable V1-9	Mus musculus	117-122
14740450-10	2003	The administration of LY309887 suppressed the disease progression of CIA mice as defined by the lower arthritis index, and decreased production of serum IgG1 and IgG2a anti-type II collagen antibody, and the damage to cartilage or bone.	6R-2',5'-thienyl-5,10-dideazatetrahydrofolic acid	22-30	immunoglobulin heavy variable V1-9	Mus musculus	162-167
15238705-6	2004	The N -propionyl, N - iso- butanoyl and N -phenylacetyl derivatives of neuraminic acid provoked robust immune responses of various antibody isotypes, including IgM, IgG1, IgG2a and IgG3, whereas N -trifluoropropionylneuraminic acid and natural Neu5Ac were essentially nonimmunogenic.	n -propionyl, n - iso- butanoyl	4-35	immunoglobulin heavy variable V1-9	Mus musculus	171-176
15238705-6	2004	The N -propionyl, N - iso- butanoyl and N -phenylacetyl derivatives of neuraminic acid provoked robust immune responses of various antibody isotypes, including IgM, IgG1, IgG2a and IgG3, whereas N -trifluoropropionylneuraminic acid and natural Neu5Ac were essentially nonimmunogenic.	n -phenylacetyl	40-55	immunoglobulin heavy variable V1-9	Mus musculus	171-176
15238705-6	2004	The N -propionyl, N - iso- butanoyl and N -phenylacetyl derivatives of neuraminic acid provoked robust immune responses of various antibody isotypes, including IgM, IgG1, IgG2a and IgG3, whereas N -trifluoropropionylneuraminic acid and natural Neu5Ac were essentially nonimmunogenic.	Neuraminic Acids	71-86	immunoglobulin heavy variable V1-9	Mus musculus	171-176
14634091-5	2003	Although the total IgG anti-CII response was only minimally affected by estrogen treatment, a significant reduction in the levels of IgG2a anti-CII Abs and an increase in the levels of IgG1 anti-CII Abs were observed in estradiol-treated mice.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	144-147	immunoglobulin heavy variable V1-9	Mus musculus	133-138
14634091-5	2003	Although the total IgG anti-CII response was only minimally affected by estrogen treatment, a significant reduction in the levels of IgG2a anti-CII Abs and an increase in the levels of IgG1 anti-CII Abs were observed in estradiol-treated mice.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	144-147	immunoglobulin heavy variable V1-9	Mus musculus	133-138
14634091-5	2003	Although the total IgG anti-CII response was only minimally affected by estrogen treatment, a significant reduction in the levels of IgG2a anti-CII Abs and an increase in the levels of IgG1 anti-CII Abs were observed in estradiol-treated mice.	Estradiol	220-229	immunoglobulin heavy variable V1-9	Mus musculus	133-138
14585674-5	2003	As expected for a saponin vaccine, the highest ratios were found in relation to IgG1, IgG2a and IgG2b (4.4, 5 and 2.5, respectively).	Saponins	18-25	immunoglobulin heavy variable V1-9	Mus musculus	86-91
15163112-7	2004	The serum levels of IgG-class anti-DNA antibodies, which had been elevated before the treatment, were suppressed--especially in the IgG2a subclass--and the deposition of IgG2a and IgG2b in the glomeruli was reduced in the group treated with 10 mg/kg/day of FK506 compared with the other groups.	Tacrolimus	257-262	immunoglobulin heavy variable V1-9	Mus musculus	170-175
14644661-4	2003	Before the development of proteinuria, BPA-fed NZB/NZW mice produced significantly less ConA-stimulated IFN-gamma than did controls and displayed an average reduction of 50% in immunoglobulin G2a (IgG2a) antibody production from lipopolysaccharide (LPS)-stimulated splenocytes (p < 0.05).	bisphenol A	39-42	immunoglobulin heavy variable V1-9	Mus musculus	197-202
14644661-8	2003	The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice.	bisphenol A	28-31	immunoglobulin heavy variable V1-9	Mus musculus	49-54
14738593-6	2003	The anti-rheumatic drug inhibited both anti-OVA IgG2a and IgG1 production, although the inhibitory effect of MTX on the antigen-specific IgG2a production appeared to be greater than that on IgG1 production.	Methotrexate	109-112	immunoglobulin heavy variable V1-9	Mus musculus	137-142
14738593-9	2003	The suppression of the joint inflammation by MTX was associated with inhibition of OVA-specific proliferative responses of spleen cells, anti-OVA IgG, IgG2a and IgG1 production, and IFN-gamma and IL-10 secretion, although more pronounced decreases in IgG2a and IFN-gamma were observed compared with those in IgG1 and IL-10 in MTX-treated mice.	Methotrexate	45-48	immunoglobulin heavy variable V1-9	Mus musculus	151-156
14738593-9	2003	The suppression of the joint inflammation by MTX was associated with inhibition of OVA-specific proliferative responses of spleen cells, anti-OVA IgG, IgG2a and IgG1 production, and IFN-gamma and IL-10 secretion, although more pronounced decreases in IgG2a and IFN-gamma were observed compared with those in IgG1 and IL-10 in MTX-treated mice.	Methotrexate	45-48	immunoglobulin heavy variable V1-9	Mus musculus	251-256
12184919-7	2002	The presence of ESAT-6 as a fusion partner with P71 during immunization, however, resulted in an enhanced P71-specific IFN-gamma response, decreased release of IL-10, and significantly greater (p < 0.05) IgG2a antibody levels in comparison to immunizing with P71 alone.	esat-6	16-22	immunoglobulin heavy variable V1-9	Mus musculus	207-212
13679386-7	2003	Splenocytes and, particularly, CD4(+) T cells from mice immunized with STxB-OVA also produced higher amounts of the T(h)1 cytokine IFN-gamma and IgG2a-type antibodies than mice immunized with non-vectorized ovalbumin.	stxb-ova	71-79	immunoglobulin heavy variable V1-9	Mus musculus	145-150
12972260-5	2003	Notably, mutation of the poorly conserved residue Leu137 of human FcRn to glutamic acid (L137E) generates a human FcRn mutant that binds to mouse IgG1 and mouse IgG2a with equilibrium dissociation constants of 13.2 microM and 14.4 microM, respectively.	Glutamic Acid	74-87	immunoglobulin heavy variable V1-9	Mus musculus	161-166
12884258-7	2003	Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.	Indomethacin	18-30	immunoglobulin heavy variable V1-9	Mus musculus	138-143
12798636-6	2003	MSP1(19)-specific antibodies in MSP1(19)-immunized mice adjuvanted with Montanide ISA51 or Montanide ISA720 showed predominantly IgG1 antibody and low levels of IgG2a.	montanide ISA 51	72-87	immunoglobulin heavy variable V1-9	Mus musculus	161-166
12798636-6	2003	MSP1(19)-specific antibodies in MSP1(19)-immunized mice adjuvanted with Montanide ISA51 or Montanide ISA720 showed predominantly IgG1 antibody and low levels of IgG2a.	montanide	72-81	immunoglobulin heavy variable V1-9	Mus musculus	161-166
12798636-7	2003	CpG ODN 1826 significantly enhanced both IgG1 and IgG2a antibody responses in Montanide ISA51-adjuvanted mice but significantly enhanced only the IgG2a antibody response in Montanide ISA720-adjuvanted mice.	montanide	78-87	immunoglobulin heavy variable V1-9	Mus musculus	50-55
12798636-7	2003	CpG ODN 1826 significantly enhanced both IgG1 and IgG2a antibody responses in Montanide ISA51-adjuvanted mice but significantly enhanced only the IgG2a antibody response in Montanide ISA720-adjuvanted mice.	mannide monooleate	173-189	immunoglobulin heavy variable V1-9	Mus musculus	146-151
12711627-10	2003	Anti-HEL IgG2a production and IFN-gamma secretion were significantly enhanced in mice treated with 300 and 30 micro g kg(-1) of BPA, respectively, while anti-HEL IgG1 production and IL-4 secretion were augmented in animals given 3000 and 300 micro g kg(-1) of the chemical, respectively.	bisphenol A	128-131	immunoglobulin heavy variable V1-9	Mus musculus	9-14
12207839-7	2002	Combination with high levels of alpha-tocopherol did not affect the reduced prostaglandin E2 production, augmented the increase of tumour necrosis factor alpha production and tended to ameliorate the selective suppressive effects of n-3 PUFA on certain Th1-driven effects (interferon-gamma:interleukin 4 ratio and IgG2a levels).	alpha-Tocopherol	32-48	immunoglobulin heavy variable V1-9	Mus musculus	314-319
12186398-6	2002	However, AEEH treatment significantly blocked the suppression of total serum and antigen-specific IgG2a antibodies, phagocytic activity and DTH response by the oral OVA.	aeeh	9-13	immunoglobulin heavy variable V1-9	Mus musculus	98-103
14568420-4	2003	Encapsulated Ole e 1 induced specific and long-lasting antibodies that were predominantly of the IgG2a isotype.	ole e 1	13-20	immunoglobulin heavy variable V1-9	Mus musculus	97-102
12917264-9	2003	Large amounts of IgG1 anti-RHA autoantibodies were detected in the sera of xid mice, whereas pristane-induced anti-nRNP/Sm and -Su autoantibodies were almost exclusively IgG2a.	pristane	93-101	immunoglobulin heavy variable V1-9	Mus musculus	170-175
12767694-8	2003	After 31 weeks, there were increases in IgG2a in mice exposed to low doses of cadmium.	Cadmium	78-85	immunoglobulin heavy variable V1-9	Mus musculus	40-45
12732659-1	2003	IgG1, IgG2a, and IgG2b, passively administered with soluble Ags, enhance specific Ab responses.	Silver	60-63	immunoglobulin heavy variable V1-9	Mus musculus	6-11
12505274-9	2003	Additionally, mercuric chloride treated mice had elevated serum levels of IgG1, IgG2a and IgE and developed anti-nuclear and anti-collagen antibodies.	Mercuric Chloride	14-31	immunoglobulin heavy variable V1-9	Mus musculus	80-85
12115200-9	2002	EtxB markedly reduced levels of anti-CII IgG2a antibodies and interferon-gamma (IFNgamma) production while not affecting levels of IgG1, interleukin-4 (IL-4), or IL-10.	etxb	0-4	immunoglobulin heavy variable V1-9	Mus musculus	41-46
11897991-7	2002	The inhibitory effect of Amb a 1-ISS was associated with a marked increase in IFN-gamma levels by Amb a 1-stimulated splenocytes and a shift in the antibody profile from a T(H)2-directed IgG1 response to a T(H)1-directed IgG2a response.	amb a 1-iss	25-36	immunoglobulin heavy variable V1-9	Mus musculus	221-226
12243733-4	2002	QS-21 was the only adjuvant to elicit predominantly IgG2a response and antibodies reactive with all epitopes incorporated in the vaccine construct.	saponin QA-21V1	0-5	immunoglobulin heavy variable V1-9	Mus musculus	52-57
11992736-10	2002	Streptozotocin (1.00 mg) caused significant increases in PLN cellularity, IgM AFCs, and selectively induced IgG(2a) and IgG(2b) AFCs against TNP-OVA.	Streptozocin	0-14	immunoglobulin heavy variable V1-9	Mus musculus	108-114
11975761-9	2002	However, these mice did not show any reduction in the number of splenic antibody-secreting cells and/or in serum titres of specific IgM, IgG1 and IgG2a anti-HRBC antibodies in response to HRBC as compared with naive mice.	hrbc	157-161	immunoglobulin heavy variable V1-9	Mus musculus	146-151
11999345-5	2002	In contrast, the saponin adjuvant enhanced both IgG2a and IgG1, and the sera showed elevated specific IgE concentrations.	Saponins	17-24	immunoglobulin heavy variable V1-9	Mus musculus	48-53
11897991-7	2002	The inhibitory effect of Amb a 1-ISS was associated with a marked increase in IFN-gamma levels by Amb a 1-stimulated splenocytes and a shift in the antibody profile from a T(H)2-directed IgG1 response to a T(H)1-directed IgG2a response.	amb a 1	25-32	immunoglobulin heavy variable V1-9	Mus musculus	221-226
11553589-1	2001	Variable-region-identical mouse immunoglobulin G1 (IgG1), IgG2b, and IgG2a monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans prolong the lives of mice infected with this fungus, while IgG3 is either not protective or enhances infection.	Polysaccharides	113-127	immunoglobulin heavy variable V1-9	Mus musculus	69-74
11858879-5	2002	Mice immunized orally with the long schedule, 50 microg of RT vaccine incorporated into poly-DL-lactide-co-glycolyde (DL-PLG) microspheres (MS) produced serum IgG, IgG2a and IgA ELISA antibodies.	poly-dl-lactide-co-glycolyde	88-116	immunoglobulin heavy variable V1-9	Mus musculus	164-169
11858879-5	2002	Mice immunized orally with the long schedule, 50 microg of RT vaccine incorporated into poly-DL-lactide-co-glycolyde (DL-PLG) microspheres (MS) produced serum IgG, IgG2a and IgA ELISA antibodies.	dl-plg	118-124	immunoglobulin heavy variable V1-9	Mus musculus	164-169
11675368-4	2001	Here we demonstrate that immunization with a multiple antigen peptide (MAP) mimetic of sugar constituents of neolactoseries antigens induces a MHC-dependent peptide-specific cellular response that triggers IFN-gamma production upon peptide stimulation, correlating with IgG2a induction.	Sugars	87-92	immunoglobulin heavy variable V1-9	Mus musculus	270-275
11401996-7	2001	Equivalent levels of induction of spleen gamma interferon mRNA and anti-lipopolysaccharide (LPS) of immunoglobulin G2a (IgG2a) subtype antibodies were observed in mice injected with B. abortus S19 or the cgs mutant.	lps	92-95	immunoglobulin heavy variable V1-9	Mus musculus	120-125
11427276-5	2001	Addition of an oligodeoxynucleotide (ODN) containing immunostimulatory cytosine-phosphate-guanosine (CpG) motifs to P29-KLH conjugate also induced a higher ratio of IgG2a/IgG1 and significantly higher titer of neutralizing antibodies.	Oligodeoxyribonucleotides	15-35	immunoglobulin heavy variable V1-9	Mus musculus	165-170
11427276-5	2001	Addition of an oligodeoxynucleotide (ODN) containing immunostimulatory cytosine-phosphate-guanosine (CpG) motifs to P29-KLH conjugate also induced a higher ratio of IgG2a/IgG1 and significantly higher titer of neutralizing antibodies.	Oligodeoxyribonucleotides	37-40	immunoglobulin heavy variable V1-9	Mus musculus	165-170
11427276-5	2001	Addition of an oligodeoxynucleotide (ODN) containing immunostimulatory cytosine-phosphate-guanosine (CpG) motifs to P29-KLH conjugate also induced a higher ratio of IgG2a/IgG1 and significantly higher titer of neutralizing antibodies.	cytosine-phosphate-guanosine	71-99	immunoglobulin heavy variable V1-9	Mus musculus	165-170
11427276-5	2001	Addition of an oligodeoxynucleotide (ODN) containing immunostimulatory cytosine-phosphate-guanosine (CpG) motifs to P29-KLH conjugate also induced a higher ratio of IgG2a/IgG1 and significantly higher titer of neutralizing antibodies.	p29-klh	116-123	immunoglobulin heavy variable V1-9	Mus musculus	165-170
11456123-5	2001	In the culture supernatants of splenocytes obtained from GRN- or SPG-OH-administered mice, high levels of IgGI and low levels of IgG2a and IFN gamma were detected.	grifolan	57-60	immunoglobulin heavy variable V1-9	Mus musculus	129-134
11456123-5	2001	In the culture supernatants of splenocytes obtained from GRN- or SPG-OH-administered mice, high levels of IgGI and low levels of IgG2a and IFN gamma were detected.	spg-oh	65-71	immunoglobulin heavy variable V1-9	Mus musculus	129-134
11293507-11	2001	In Os-mice treated with OVA-DT, levels of anti-OVA IgG2a in serum and the production of IFN-gamma by splenic lymphocytes were found to increase, but the production of IL-4 by these cells decreased.	ova-dt	24-30	immunoglobulin heavy variable V1-9	Mus musculus	51-56
11306428-6	2001	In wild-type animals, silica-induced fibrosis correlated with markers of a T helper 2-like response such as upregulation of IL-4 levels in lung tissue and an increased immunoglobulin (Ig) G1/IgG2a ratio in BAL.	Silicon Dioxide	22-28	immunoglobulin heavy variable V1-9	Mus musculus	191-196
11306428-8	2001	In transgenic mice, the level of IL-4 in lung homogenates was not significantly affected by silica treatment, and a reduced IgG1/IgG2a ratio was observed upon treatment with silica.	Silicon Dioxide	174-180	immunoglobulin heavy variable V1-9	Mus musculus	129-134
11379043-4	2001	The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b.	kml-c	63-68	immunoglobulin heavy variable V1-9	Mus musculus	117-122
11379043-4	2001	The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b.	CHEMBL2385481	79-82	immunoglobulin heavy variable V1-9	Mus musculus	117-122
11379048-6	2001	Total serum IgG2a levels and Il-4 secretion were also statistically augmented by all groups of AEEH treatment.	aeeh	95-99	immunoglobulin heavy variable V1-9	Mus musculus	12-17
11212944-0	2001	Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	Corticosterone	120-134	immunoglobulin heavy variable V1-9	Mus musculus	46-51
11212944-5	2001	Cumulative corticosterone exposure in these mice, expressed as the area under the curve (AUC) of corticosterone concentration versus time, was used to develop quantitative models of the effects of corticosterone on the immunoglobulin (Ig) G1 and IgG2a responses to keyhole limpet hemocyanin (KLH) and sheep erythrocytes (sRBC).	Corticosterone	11-25	immunoglobulin heavy variable V1-9	Mus musculus	246-251
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy variable V1-9	Mus musculus	205-210
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy variable V1-9	Mus musculus	205-210
11212944-11	2001	The relationships between corticosterone AUC and the IgG1 and IgG2a responses to sRBC were nonlinear and characterized by enhanced responses at low to moderate AUC values.	Corticosterone	26-40	immunoglobulin heavy variable V1-9	Mus musculus	62-67
11122451-3	2000	Both IgG1 and IgG2a anti-BSA levels were higher in mice immunized with BSA conjugated to dextran of molecular weight (MW) 5 000 000-40 000 000 compared with dextran of MW 10,000-60,000.	Dextrans	89-96	immunoglobulin heavy variable V1-9	Mus musculus	14-19
11150005-5	2001	RESULTS: The administration of kanamycin increased the serum levels of total IgG1 and IgE while decreasing the serum IgG2a levels.	Kanamycin	31-40	immunoglobulin heavy variable V1-9	Mus musculus	117-122
11814234-10	2001	We also demonstrated the existence in vivo of alternative or concomitant use of perforine- and Fas-mediated cytotoxicity pathways in this T cell-induced IgG2a(b) suppression.	Perforine	80-89	immunoglobulin heavy variable V1-9	Mus musculus	153-158
11814234-10	2001	We also demonstrated the existence in vivo of alternative or concomitant use of perforine- and Fas-mediated cytotoxicity pathways in this T cell-induced IgG2a(b) suppression.	ammonium ferrous sulfate	95-98	immunoglobulin heavy variable V1-9	Mus musculus	153-158
11190487-1	2000	UNLABELLED: Preliminary evaluations of 125I-labeled Lym-1, an anti-lymphoma mouse IgG2a monoclonal antibody, demonstrated favorable tumor uptake in mice bearing human Burkitt"s lymphoma (Raji) tumors.	Iodine-125	39-43	immunoglobulin heavy variable V1-9	Mus musculus	82-87
11032768-11	2000	CBP-treated animals show even higher IgG1 and IgE levels and AFC numbers, and in addition display IgG2a production.	4,4'-Bis(N-carbazolyl)-1,1'-biphenyl	0-3	immunoglobulin heavy variable V1-9	Mus musculus	98-103
11053543-5	2000	Linear relationships between corticosterone AUC values and suppression of the following parameters were noted in B6C3F1 female mice: thymus cellularity and thymus subpopulation percentages, splenic subpopulation percentages, natural killer cell activity, MHC class II protein expression, and IgG1 and IgG2a antibody responses to antigen.	Corticosterone	29-43	immunoglobulin heavy variable V1-9	Mus musculus	301-306
10809147-6	2000	Both intrasplenic and intramuscular administration of pCEA generated IgG2a antibody responses to CEA, consistent with the induction of T helper-1-biased immune responses.	pcea	54-58	immunoglobulin heavy variable V1-9	Mus musculus	69-74
10948186-4	2000	Thus, PC appears to block production of IgG2a antibodies to other epitopes on the parasite molecule.	Phosphorylcholine	6-8	immunoglobulin heavy variable V1-9	Mus musculus	40-45
10915562-8	2000	Finally, R-848 was shown to act as a vaccine adjuvant enhancing OVA-specific IgG2a levels while suppressing total IgE.	resiquimod	9-14	immunoglobulin heavy variable V1-9	Mus musculus	77-82
10996030-4	2000	The serum level of anti-CII IgG2a and the production of IFN-gamma and IL-12 in the draining lymph node (LN) cells were significantly lower in AZ-9-administered mice than the untreated control.	az-9	142-146	immunoglobulin heavy variable V1-9	Mus musculus	28-33
11051277-9	2000	CR significantly inhibited the elevated levels of IgA and IgG2a seen in aged mice.	Chromium	0-2	immunoglobulin heavy variable V1-9	Mus musculus	58-63
10950973-5	2000	These conclusions are based on the finding that the IgG2a hypergammaglobulinaemia and immune complex formation were much lower in mice that were infected with LDV variants (LDV-C and LDV-v) whose VP-3P ectodomains lack two of the three N-glycans than in LDV-P/vx infected mice.	n-glycans	236-245	immunoglobulin heavy variable V1-9	Mus musculus	52-57
10700464-8	2000	The analysis of anti-CHO IgG subclasses showed a significant increase of IgG2a and IgG3 in the presence of ISS.	CAV protocol	21-24	immunoglobulin heavy variable V1-9	Mus musculus	73-78
10656674-9	1999	Our finding that the lysine P9 residue of the corresponding gamma2a(a) allopeptide precludes high-affinity binding to I-Ad indicates that the susceptibility of IgG2a(a) mice reflects inefficient thymic presentation of autologous IgG2a and thus failure to purge the T-cell repertoire of the pathogenic clones.	lysine p9	21-30	immunoglobulin heavy variable V1-9	Mus musculus	160-165
10705972-1	2000	When mice were placed on diets extreme deficient in vitamin B6, ovalbumin-dependent antibody productions (IgE, IgG1, IgG2a) were significantly suppressed, and alanine aminotransferase activity in the liver was also significantly decreased.	Vitamin B 6	52-62	immunoglobulin heavy variable V1-9	Mus musculus	117-122
10738854-8	1999	Interestingly, age resulted in a decrease of Th-1 cytokine-induced IgA and IgM, and increased IgG2a secretion in AL mice, while Th-2 cytokines did not appear to have an age effect.	Aluminum	113-115	immunoglobulin heavy variable V1-9	Mus musculus	94-99
10656674-9	1999	Our finding that the lysine P9 residue of the corresponding gamma2a(a) allopeptide precludes high-affinity binding to I-Ad indicates that the susceptibility of IgG2a(a) mice reflects inefficient thymic presentation of autologous IgG2a and thus failure to purge the T-cell repertoire of the pathogenic clones.	lysine p9	21-30	immunoglobulin heavy variable V1-9	Mus musculus	229-234
10418902-6	1999	Coincidentally with this reduction, an increase in antibodies of the IgG2a subtype was detected only in animals treated with FML + saponin i.p.	calenduloside E	131-140	immunoglobulin heavy variable V1-9	Mus musculus	69-74
10575554-4	1999	In addition, trichloroethylene treatment accelerated the development of an autoimmune response in the MRL +/+ mice as evidenced by an earlier appearance of antinuclear antibodies and increased levels of total IgG2a.	Trichloroethylene	13-30	immunoglobulin heavy variable V1-9	Mus musculus	209-214
10550747-7	1999	In contrast, coadminstration of CpG-ODNs with Bet v 1 in aluminium hydroxide resulted in markedly increased T(H1) activities (high IgG2a levels) and subsequently to reduced airway inflammation.	Aluminum Hydroxide	57-76	immunoglobulin heavy variable V1-9	Mus musculus	131-136
10583591-4	1999	The mice orally tolerized with low Dp dose (0.25 mg) had a significant decrease in the total serum IgE and in the immunoglobulin G1 (IgG1), IgG2a and IgG2b antibody levels.	dp	35-37	immunoglobulin heavy variable V1-9	Mus musculus	140-145
10446861-6	1999	Protection with nasal CTB-CII vaccine was associated with decreased production of interleukin-4 (IL-4), IL-6, and interferon-gamma and with reduced CII-specific IgG1 and IgG2a antibody responses in regional lymph nodes.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	26-29	immunoglobulin heavy variable V1-9	Mus musculus	170-175
10367954-3	1999	The use of DC-Chol increased antibody responses in responding BALB/c mice, induced more consistent IgG1 and IgG2a antibody responses in OF1 mice and overcame the nonresponse to HBsAg in B10.M mice.	3-(N-(N',N'-dimethylaminoethane)carbamoyl)cholesterol	11-18	immunoglobulin heavy variable V1-9	Mus musculus	108-113
10225870-6	1999	Even in the presence of overt infection, TNP-KLH-plus-rmIL-12-immunized mice were still capable of generating KLH-specific gamma interferon (IFN-gamma) as well as corresponding TNP-specific immunoglobulin G2a (IgG2a) titers.	picric acid	41-44	immunoglobulin heavy variable V1-9	Mus musculus	210-215
10225870-6	1999	Even in the presence of overt infection, TNP-KLH-plus-rmIL-12-immunized mice were still capable of generating KLH-specific gamma interferon (IFN-gamma) as well as corresponding TNP-specific immunoglobulin G2a (IgG2a) titers.	rmil-12	54-61	immunoglobulin heavy variable V1-9	Mus musculus	210-215
10195640-2	1999	Intraperitoneal immunisation of mice with these rBCG induced IgG and IgA antibodies to LT-Bh and shifted the serum IgG subclass response to subsequent challenge with purified LT-Bh from IgG1 to an IgG2a.	rbcg	48-52	immunoglobulin heavy variable V1-9	Mus musculus	197-202
10217611-7	1999	The immune response elicited by pCB01 was mainly due to IgG2a, while that elicited by a bacterin was due to IgG2b and IgG3.	pcb01	32-37	immunoglobulin heavy variable V1-9	Mus musculus	56-61
10051631-8	1999	When immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1 cytokine-dependent-IgG2a antitrinitrophenyl antibody.	1,3-dibromo-5,5-dimethylhydantoin	62-65	immunoglobulin heavy variable V1-9	Mus musculus	111-116
9973420-4	1999	Oligodeoxynucleotides (ODN) containing CpG motifs activate neonatal APCs to produce IL-12 in vitro and induce adult-like Th1 responses to tetanus toxoid and measles Ags in vivo, with production of IgG2a-specific Abs and adult-like secretion of IFN-gamma and IL-5 by Ag-specific T cells.	Oligodeoxyribonucleotides	0-21	immunoglobulin heavy variable V1-9	Mus musculus	197-202
10353461-3	1999	Priming and boosting of mice with gp 160 adsorbed to aluminium hydroxide (Alum) induced a typical T helper-2 (Th2)-dominated immune response with high titers of gp 160-specific immunoglobulin (Ig)G1 isotypes but a weak IgG2a response.	Aluminum Hydroxide	53-72	immunoglobulin heavy variable V1-9	Mus musculus	219-224
10353461-3	1999	Priming and boosting of mice with gp 160 adsorbed to aluminium hydroxide (Alum) induced a typical T helper-2 (Th2)-dominated immune response with high titers of gp 160-specific immunoglobulin (Ig)G1 isotypes but a weak IgG2a response.	Aluminum Hydroxide	74-78	immunoglobulin heavy variable V1-9	Mus musculus	219-224
10028020-6	1999	All mice in both CII245-270- and CII260-270-treated groups had a reduced serum level of anti-CII antibody (P<0.01), with a marked reduction of IgG2a.	cii245	17-23	immunoglobulin heavy variable V1-9	Mus musculus	146-151
10028020-6	1999	All mice in both CII245-270- and CII260-270-treated groups had a reduced serum level of anti-CII antibody (P<0.01), with a marked reduction of IgG2a.	cii260	33-39	immunoglobulin heavy variable V1-9	Mus musculus	146-151
10233715-9	1999	To further explore the role of Th1/Th2 cytokines in the mercury model, we performed anti-interferon-gamma antibody treatment in IL-4-deficient mice together with mercury treatment and found that the production of IgG2a and IgG3, but not IgG2b, antibodies was downregulated.	Mercury	56-63	immunoglobulin heavy variable V1-9	Mus musculus	213-218
10233715-9	1999	To further explore the role of Th1/Th2 cytokines in the mercury model, we performed anti-interferon-gamma antibody treatment in IL-4-deficient mice together with mercury treatment and found that the production of IgG2a and IgG3, but not IgG2b, antibodies was downregulated.	Mercury	162-169	immunoglobulin heavy variable V1-9	Mus musculus	213-218
10355966-4	1999	In MRL-Ipr(cg) mice, an immunosuppressive agent, FK506, improved the serological abnormalities (decreased levels of anti-double-stranded DNA antibody of IgG2a and IgG3 subclasses) and proteinuria.	Tacrolimus	49-54	immunoglobulin heavy variable V1-9	Mus musculus	153-158
9820529-2	1998	Even when converted to T-dependent forms through conjugation to foreign proteins, polysaccharides induce responses that are deficient in many respects, such as induction of murine IgG2a Ab, the isotype that mediates optimal complement fixation and opsonization.	Polysaccharides	82-97	immunoglobulin heavy variable V1-9	Mus musculus	180-185
10078607-4	1999	Mice immunized with the gB plasmid predominantly produced IgG2a gB-specific antibody, while the gB680 plasmid raised mostly IgG1 anti-gB antibody.	gb	24-26	immunoglobulin heavy variable V1-9	Mus musculus	58-63
9601496-3	1998	Oral inoculation of EHPw and SA11 induced a similar pattern of Ab with mucosal and serum IgA associated with serum IgG with equal levels of IgG1 and IgG2a, whereas RF elicited a weak humoral response.	sa11	29-33	immunoglobulin heavy variable V1-9	Mus musculus	149-154
9822261-9	1998	Sera of both mercury- and saline-treated mice immunized with HRBCs showed high titres of specific IgM, IgG1 and IgG2a anti-HRBCs antibodies.	Mercury	13-20	immunoglobulin heavy variable V1-9	Mus musculus	112-117
9822261-9	1998	Sera of both mercury- and saline-treated mice immunized with HRBCs showed high titres of specific IgM, IgG1 and IgG2a anti-HRBCs antibodies.	hrbcs	61-66	immunoglobulin heavy variable V1-9	Mus musculus	112-117
9822261-10	1998	Surprisingly, 3-week treatment with mercury induced a reduction in the titres of specific IgG2a anti-HRBCs antibodies in DBA/2 mice after immunization with HRBCs.	Mercury	36-43	immunoglobulin heavy variable V1-9	Mus musculus	90-95
9822261-10	1998	Surprisingly, 3-week treatment with mercury induced a reduction in the titres of specific IgG2a anti-HRBCs antibodies in DBA/2 mice after immunization with HRBCs.	hrbcs	101-106	immunoglobulin heavy variable V1-9	Mus musculus	90-95
9780187-3	1998	Moreover, administration of KLH with HKL as an adjuvant reversed established immune responses dominated by the production of Th2 cytokines and high levels of KLH-specific IgE and induced a Th1-type response with high levels of IFN-gamma and IgG2a and low levels of IgE and IL-4.	hkl	37-40	immunoglobulin heavy variable V1-9	Mus musculus	241-246
9764596-7	1998	While mercury-treated IL-4(-/-) H-2S mice had virtually no detectable serum IgG1 or IgE, and very low levels of IgG1 ANoA, these mice had levels of IgG2a and IgG2b class ANoA comparable to mercury-treated IL-4+ H-2S mice, indicating that IL-4 is not required for the ANoA response in mercury-induced autoimmunity.	Mercury	6-13	immunoglobulin heavy variable V1-9	Mus musculus	148-153
9673276-9	1998	In mice infected with transformed non-gametocyte-producing parasites, a Pbs21-specific immune response was induced and characterized with respect to isotype (IgG2a/IgG2b) and quantity (11.	pbs21	72-77	immunoglobulin heavy variable V1-9	Mus musculus	158-163
9780043-8	1998	In ribavirin-treated HBeAg-Tg mice anti-HBe IgG1 (positively regulated by Th2 cytokines) decreased simultaneously as both anti-HBe IgG2a (positively regulated by Th1 cytokines) levels and in vitro T-cell IFN-gamma production increased, indicating a change in the Th1/Th2 balance.	Ribavirin	3-12	immunoglobulin heavy variable V1-9	Mus musculus	131-136
9683552-4	1998	The mice administered denatured or digested CII possessed much lower titers of anti-CII IgG2a than the control mice, whereas titers of anti-CII IgG1 and IgG2b were unchanged or slightly decreased.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	44-47	immunoglobulin heavy variable V1-9	Mus musculus	88-93
9730089-5	1998	Moreover, DHEA-fed mice had higher serum IgG2a level than control diet-fed mice.	Dehydroepiandrosterone	10-14	immunoglobulin heavy variable V1-9	Mus musculus	41-46
9720139-6	1998	When the IgG2a/IgG1 ratios were determined to indicate the type of T helper cell involved, the highest values were obtained with AOO and lowest with DMF and DMSO, while acetone and ethanol were in between.	Atraton	129-132	immunoglobulin heavy variable V1-9	Mus musculus	9-14
9720139-6	1998	When the IgG2a/IgG1 ratios were determined to indicate the type of T helper cell involved, the highest values were obtained with AOO and lowest with DMF and DMSO, while acetone and ethanol were in between.	Dimethyl Sulfoxide	157-161	immunoglobulin heavy variable V1-9	Mus musculus	9-14
9629306-9	1998	RST significantly suppressed the number of virus-specific ASC (IgM, IgG and subclasses IgG1 and IgG2a) in the lungs, mediastinal (MLN) lymph nodes and spleen, while it enhanced the responses in the superficial cervical (SCV) lymph nodes.	UNII-Y5T2AJP16N	0-3	immunoglobulin heavy variable V1-9	Mus musculus	96-101
9551923-7	1998	In contrast, CpG ODN gives a strong Thl response with predominantly IgG2a Abs and CTL, even when mixed with alum.	Orlistat	36-39	immunoglobulin heavy variable V1-9	Mus musculus	68-73
9472679-4	1998	On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype.	Melatonin	55-64	immunoglobulin heavy variable V1-9	Mus musculus	164-169
9353153-5	1997	We found that young (NZB x NZW)F1 mice injected with mercuric chloride (HgCl2) for 6 weeks developed intense antibody formation of all immunoglobulin isotypes (except for IgG2b) as well as high levels of granular deposits of IgM, IgG1, IgG2a and IgG3 antibodies in the renal mesangium.	Mercuric Chloride	53-70	immunoglobulin heavy variable V1-9	Mus musculus	236-241
9472674-4	1998	Allergen-specific serum IgE and IgG1 antibodies dominated in the Al(OH)3 group, IgG2a antibody levels to BP and rBet v 1 were markedly higher in the sera of mice exposed to CT with the allergen.	Benzo(a)pyrene	105-107	immunoglobulin heavy variable V1-9	Mus musculus	80-85
9413106-3	1997	Mice vaccinated with the purified E mixed with aluminium hydroxide adjuvant showed an immune response of IgM and IgG1, IgG2a and IgG2b isotypes, and neutralizing antibodies, similar to that following immunization with purified inactivated DEN-2 virus.	Aluminum Hydroxide	47-66	immunoglobulin heavy variable V1-9	Mus musculus	119-124
9353153-5	1997	We found that young (NZB x NZW)F1 mice injected with mercuric chloride (HgCl2) for 6 weeks developed intense antibody formation of all immunoglobulin isotypes (except for IgG2b) as well as high levels of granular deposits of IgM, IgG1, IgG2a and IgG3 antibodies in the renal mesangium.	Mercuric Chloride	72-77	immunoglobulin heavy variable V1-9	Mus musculus	236-241
9228656-1	1997	2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (C-NOTA) or 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid (1B4M) was conjugated to monoclonal antibody T101 (IgG2a), radiolabeled with 111In or 67Ga and then purified through size-exclusion HPLC.	(p-SCN-Bn)-NOTA	0-71	immunoglobulin heavy variable V1-9	Mus musculus	207-212
9268502-8	1997	DO11.10 transgenic mouse exposed to Pb and antigen also demonstrated a skewed type-2 response evidenced by significantly increased IgE levels, lowered IFN-gamma levels, and increased IgG1 and lowered IgG2a anti-OVA levels.	Lead	36-38	immunoglobulin heavy variable V1-9	Mus musculus	200-205
9322064-11	1997	In contrast, heparinized polyethylene-implanted animals showed a significant decrease in the production of anti-protein A IgG2b and anti-alpha-toxin IgG2a and IgG2b.	Polyethylene	25-37	immunoglobulin heavy variable V1-9	Mus musculus	149-154
9217364-10	1997	Both anti-CII IgG and anti-CII IgG 2 a levels in serum were reduced in mice injected CII before induction of CIA.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	27-30	immunoglobulin heavy variable V1-9	Mus musculus	31-38
9126981-5	1997	Terbutaline exposure of Th1 cells before activation inhibited IFN-gamma production by Th1 cells and subsequent IgG2a production by B cells.	Terbutaline	0-11	immunoglobulin heavy variable V1-9	Mus musculus	111-116
9126981-6	1997	IgG2a inhibition was prevented by addition of the betaAR antagonist nadolol or exogenous IFN-gamma.	Nadolol	68-75	immunoglobulin heavy variable V1-9	Mus musculus	0-5
9138036-6	1997	Total IgG, IgG1, IgG2a, IgM and IgA immunoglobulins in the serum of beta-glucan-treated groups were overall higher than those in the non-treated group.	beta-Glucans	68-79	immunoglobulin heavy variable V1-9	Mus musculus	17-22
8805628-8	1996	TCDD abrogated the production of IgG2a (promoted by IFN-gamma), but had much less effect on the level of IgG1 (promoted by IL-4).	Polychlorinated Dibenzodioxins	0-4	immunoglobulin heavy variable V1-9	Mus musculus	33-38
9113728-6	1997	Anti-END/HRP bAbs was formed by a combination of heavy chains which belong to two subclass of IgG: IgG2a and IgG1.	babs	13-17	immunoglobulin heavy variable V1-9	Mus musculus	99-104
9043951-7	1997	In contrast, immunization of mice with particulate LH in the presence of poly(I):(C) or of IL-12 induced a strong activation of Th1 cells, as shown by an up-regulated IFN-gamma production, and by decreased IL-4 and IL-5 levels associated to a greatly enhanced IgG2a antibody response.	Luteinizing Hormone	51-53	immunoglobulin heavy variable V1-9	Mus musculus	260-265
9003747-6	1997	Previous reports have shown that wDTP and aDTP enhance the serum antibody response of mice to influenza vaccine, but wDTP enhanced the response 100-fold greater than aDTP, and induced greater IgG2a and IgG2b subclass antibody responses; this last result indicates a cell-mediated immune response to vaccine.	wdtp	117-121	immunoglobulin heavy variable V1-9	Mus musculus	192-197
8805674-6	1996	Serum levels of IgG2a anti-CII Abs in KT6-treated DBA/1 mice were significantly reduced (p < 0.001), while IgG1 anti-CII were not significantly changed (p > 0.05).	1,2,5,6-dibenzanthracene	50-53	immunoglobulin heavy variable V1-9	Mus musculus	16-21
9040006-3	1997	Using this model, murine splenic B cells (from BALB/c or C57Bl/6) were activated by mouse IgG2a-anti-IgD (10.4.22 or AF3.33) in a manner that is analogous to the activation of B cells seen with highly polyvalent anti-IgD (H delta(a)/1) prepared by chemical cross-linking to dextran.	Dextrans	274-281	immunoglobulin heavy variable V1-9	Mus musculus	90-95
8977282-4	1996	In contrast, the response of BALB/c mice was characterized as Th1 on the basis of delayed and weaker IL-4 mRNA expression associated with high anti-BPO IgG2a production (Kerdine, S. et al., Mol.	kerdine	170-177	immunoglobulin heavy variable V1-9	Mus musculus	152-157
8977282-14	1996	Together, these data demonstrate that endogenous production of IL-10 regulates the production of IgG2a Ab in response to BPO-TT and that IL-10, like IL-4, is critical for controlling primary responses to antibiotics which behave as haptenic compounds.	bpo-tt	121-127	immunoglobulin heavy variable V1-9	Mus musculus	97-102
8918571-11	1996	Our study shows that the state of glycosylation of IgG affects the t1/2 in vivo, and that by removing the terminal sugars (sialic acid and galactose), the antibody (IgG2a) will remain in circulation significantly longer.	Sugars	115-121	immunoglobulin heavy variable V1-9	Mus musculus	165-170
8918571-11	1996	Our study shows that the state of glycosylation of IgG affects the t1/2 in vivo, and that by removing the terminal sugars (sialic acid and galactose), the antibody (IgG2a) will remain in circulation significantly longer.	N-Acetylneuraminic Acid	123-134	immunoglobulin heavy variable V1-9	Mus musculus	165-170
8918571-11	1996	Our study shows that the state of glycosylation of IgG affects the t1/2 in vivo, and that by removing the terminal sugars (sialic acid and galactose), the antibody (IgG2a) will remain in circulation significantly longer.	Galactose	139-148	immunoglobulin heavy variable V1-9	Mus musculus	165-170
8849692-3	1996	Three antibodies, 2 IgG1 and 1 IgG2a, were found to bind both Fe(ToCPP) and the free base ToCPPH2 with similar binding constants.	Iron	62-64	immunoglobulin heavy variable V1-9	Mus musculus	31-36
8849692-3	1996	Three antibodies, 2 IgG1 and 1 IgG2a, were found to bind both Fe(ToCPP) and the free base ToCPPH2 with similar binding constants.	ToCPP	65-70	immunoglobulin heavy variable V1-9	Mus musculus	31-36
8849692-9	1996	studies have shown that the two IgG1-Fe(ToCPP) complexes were high-spin hexacoordinate iron(III) complexes, with no amino acid residue binding the iron, whereas the IgG2a-Fe(ToCPP) complex was a low-spin hexacoordinate iron(III) complex with two strong ligands binding the iron atom.	ToCPP	174-179	immunoglobulin heavy variable V1-9	Mus musculus	165-170
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	ToCPP	13-18	immunoglobulin heavy variable V1-9	Mus musculus	199-204
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	2,2"-azinobis	70-83	immunoglobulin heavy variable V1-9	Mus musculus	199-204
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	125-129	immunoglobulin heavy variable V1-9	Mus musculus	199-204
8849692-10	1996	Both IgG1-Fe(ToCPP) complexes were found to catalyze the oxidation of 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) 5-fold more efficiently than Fe(ToCPP) alone whereas the binding of IgG2a to this iron-porphyrin had no effect on its catalytic activity.	Iron	10-12	immunoglobulin heavy variable V1-9	Mus musculus	199-204
8757344-7	1996	Oral administration of TNBS before induction of colitis markedly decreased mucosal anti-TNP responses and completely inhibited anti-TNP IgG2a and IgG2b responses.	Trinitrobenzenesulfonic Acid	23-27	immunoglobulin heavy variable V1-9	Mus musculus	136-141
8918691-9	1996	Furthermore, it is not the H-2b haplotype of C57BL/6 mice but rather the genetic background (DBA/1 versus BL/6 or BL/10) that limits the effect of IL-12 on the CII-specific antibody response because IL-12 treatment of CII-immunized B10.Q (H-2q) mice also failed to induce arthritis and to enhance CII-specific IgG2a and IgG2b synthesis.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	160-163	immunoglobulin heavy variable V1-9	Mus musculus	310-315