PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35598637-0	2022	Plasma fatty acid composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.	Fatty Acids	7-17	sterol O-acyltransferase 2	Homo sapiens	68-73
9756920-6	1998	In vitro microsomal assays in a yeast strain deleted for both esterification genes and completely deficient in sterol esterification indicated that ARGP2 esterified cholesterol while ARGP1 did not.	Sterols	111-117	sterol O-acyltransferase 2	Homo sapiens	148-153
9756920-6	1998	In vitro microsomal assays in a yeast strain deleted for both esterification genes and completely deficient in sterol esterification indicated that ARGP2 esterified cholesterol while ARGP1 did not.	Cholesterol	165-176	sterol O-acyltransferase 2	Homo sapiens	148-153
9756920-7	1998	In contrast to ACAT1 and similar to liver esterification, the activity of ARGP2 was relatively resistant to a histidine active site modifier.	Histidine	110-119	sterol O-acyltransferase 2	Homo sapiens	74-79
35598637-0	2022	Plasma fatty acid composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.	Cholesterol Esters	82-99	sterol O-acyltransferase 2	Homo sapiens	68-73
35598637-2	2022	LCAT is the only enzyme able to esterify cholesterol in plasma, while sterol O-acyltransferase 1 and 2 (SOAT1 and SOAT2) are the enzymes esterifying cellular cholesterol in cells.	Cholesterol	158-169	sterol O-acyltransferase 2	Homo sapiens	114-119
27688150-3	2016	In this study, we further report that the ACAT2 gene expression is attributable to the C/EBPs in the human leukocytes and correlated with the excretion of fluorescent lipoproteins containing the ACAT2-catalyzed NBD22-steryl esters.	steryl esters	217-230	sterol O-acyltransferase 2	Homo sapiens	195-200
33980978-7	2021	Taken together, hepatic ApoJ might activate SOAT2 to supply cholesteryl-ester for lipid loads, thus providing a therapeutic target of stress-induced steatosis.	Cholesterol Esters	60-77	sterol O-acyltransferase 2	Homo sapiens	44-49
32058035-5	2020	In SOAT2-only-HepG2 cells, increased levels of cholesterol, triglycerides, apolipoprotein B and lipoprotein(a) in the cell media were detected; this was likely dependent of the increased expression of key genes involved in lipid metabolism (e.g. MTP, APOB, HMGCR, LDLR, ACACA, and DGAT2).	Cholesterol	47-58	sterol O-acyltransferase 2	Homo sapiens	3-8
32058035-5	2020	In SOAT2-only-HepG2 cells, increased levels of cholesterol, triglycerides, apolipoprotein B and lipoprotein(a) in the cell media were detected; this was likely dependent of the increased expression of key genes involved in lipid metabolism (e.g. MTP, APOB, HMGCR, LDLR, ACACA, and DGAT2).	Triglycerides	60-73	sterol O-acyltransferase 2	Homo sapiens	3-8
31681760-10	2019	Accordingly, inhibition of CE generating enzymes, the cholesterol acetyltransferases ACAT1/SOAT1 and ACAT2/SOAT2, impaired TCR driven expansion of both CD4+ and CD8+ T cells.	Cholesterol	54-65	sterol O-acyltransferase 2	Homo sapiens	107-112
28646165-1	2017	Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells.	beauverolides	0-17	sterol O-acyltransferase 2	Homo sapiens	83-88
28646165-1	2017	Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells.	beauverolides	0-17	sterol O-acyltransferase 2	Homo sapiens	240-245
28646165-1	2017	Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells.	beauverolides	19-26	sterol O-acyltransferase 2	Homo sapiens	83-88
28646165-1	2017	Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO cells.	beauverolides	19-26	sterol O-acyltransferase 2	Homo sapiens	240-245
27876317-3	2016	Twenty-one compounds from the spirooxindole tetrahydropyran derivatives and related molecules were screened for inhibition of sterol O-acyltransferase (SOAT) isozymes SOAT1 and SOAT2.	spirooxindole tetrahydropyran	30-59	sterol O-acyltransferase 2	Homo sapiens	177-182
27936201-4	2016	The enzymatic activity of zebrafish Soat2 was confirmed by Oil Red O staining in the HEK293 cells overexpressing this gene, and could be quenched by Soat2 inhibitor Pyripyropene A (PPPA).	pyripyropene A	165-179	sterol O-acyltransferase 2	Homo sapiens	149-154
27936201-4	2016	The enzymatic activity of zebrafish Soat2 was confirmed by Oil Red O staining in the HEK293 cells overexpressing this gene, and could be quenched by Soat2 inhibitor Pyripyropene A (PPPA).	pyripyropene A	181-185	sterol O-acyltransferase 2	Homo sapiens	149-154
27688150-0	2016	The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters.	cholesteryl/steryl esters	101-126	sterol O-acyltransferase 2	Homo sapiens	4-9
27688150-3	2016	In this study, we further report that the ACAT2 gene expression is attributable to the C/EBPs in the human leukocytes and correlated with the excretion of fluorescent lipoproteins containing the ACAT2-catalyzed NBD22-steryl esters.	steryl esters	217-230	sterol O-acyltransferase 2	Homo sapiens	42-47
28294609-5	2017	Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level.	biseokeaniamide B	0-17	sterol O-acyltransferase 2	Homo sapiens	130-135
27688150-4	2016	Moreover, this lipoprotein excretion can be inhibited by the ACAT2 isoform-selective inhibitor pyripyropene A (PPPA) in a dose-dependent manner, and employed to determine the half maximum inhibitory concentration (IC50) values of PPPA.	pyripyropene A	95-109	sterol O-acyltransferase 2	Homo sapiens	61-66
27688150-4	2016	Moreover, this lipoprotein excretion can be inhibited by the ACAT2 isoform-selective inhibitor pyripyropene A (PPPA) in a dose-dependent manner, and employed to determine the half maximum inhibitory concentration (IC50) values of PPPA.	pyripyropene A	111-115	sterol O-acyltransferase 2	Homo sapiens	61-66
27688150-4	2016	Moreover, this lipoprotein excretion can be inhibited by the ACAT2 isoform-selective inhibitor pyripyropene A (PPPA) in a dose-dependent manner, and employed to determine the half maximum inhibitory concentration (IC50) values of PPPA.	pyripyropene A	230-234	sterol O-acyltransferase 2	Homo sapiens	61-66
27688150-5	2016	Significantly, it is found that the differentiation-inducing factor all-trans retinoic acid, but not the proinflammatory cytokine tumor necrosis factor-alpha, enhances this ACAT2-dependent lipoprotein excretion.	Tretinoin	78-91	sterol O-acyltransferase 2	Homo sapiens	173-178
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	cholesteryl	129-140	sterol O-acyltransferase 2	Homo sapiens	32-37
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	steryl esters	141-154	sterol O-acyltransferase 2	Homo sapiens	32-37
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	Cesium	242-244	sterol O-acyltransferase 2	Homo sapiens	32-37
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	Cholesterol	315-327	sterol O-acyltransferase 2	Homo sapiens	32-37
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	Sterols	320-327	sterol O-acyltransferase 2	Homo sapiens	32-37
27688150-6	2016	These data demonstrate that the ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters (CE/SE), and suggest that the excretion of lipoproteins containing the ACAT2-catalyzed CS/SE may avoid cytotoxicity through decreasing the excess intracellular cholesterols/sterols (especially various oxysterols), which is essential for the action of the human leukocytes.	Oxysterols	356-366	sterol O-acyltransferase 2	Homo sapiens	32-37
24151965-4	2013	The fecal analysis showed CS-fed hamsters had the highest fecal cholesterol concentration, while RT-PCR analysis found CS feeding was associated with down-regulations of intestinal Niemann-Pick C1 like 1 (NPC1L1) and acyl-CoA: cholesterol acyltransferase 2 (ACAT2) as well as microsomal triacylglycerol transport protein (MTP).	cholesterol stearate	119-121	sterol O-acyltransferase 2	Homo sapiens	217-256
26584338-0	2016	Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).	pyripyropene A	68-82	sterol O-acyltransferase 2	Homo sapiens	103-149
25917363-1	2015	BACKGROUND: Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia.	Cholesterol Esters	108-126	sterol O-acyltransferase 2	Homo sapiens	12-57
25917363-1	2015	BACKGROUND: Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia.	Fatty Acids	148-159	sterol O-acyltransferase 2	Homo sapiens	12-57
24478032-1	2014	Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes.	Cholesterol	65-76	sterol O-acyltransferase 2	Homo sapiens	18-44
24478032-1	2014	Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes.	Cholesterol	65-76	sterol O-acyltransferase 2	Homo sapiens	46-51
24151965-4	2013	The fecal analysis showed CS-fed hamsters had the highest fecal cholesterol concentration, while RT-PCR analysis found CS feeding was associated with down-regulations of intestinal Niemann-Pick C1 like 1 (NPC1L1) and acyl-CoA: cholesterol acyltransferase 2 (ACAT2) as well as microsomal triacylglycerol transport protein (MTP).	cholesterol stearate	119-121	sterol O-acyltransferase 2	Homo sapiens	258-263
23711919-3	2013	The new o-substituted benzylidene derivatives showed higher selectivity for ACAT2 than PPPA (1).	pyripyropene A	87-91	sterol O-acyltransferase 2	Homo sapiens	76-81
24103759-8	2013	Since SOAT2 is an enzyme that generates cholesteryl esters that are packaged into lipoproteins, our results suggest miR-181d plays a significant role in the negative regulation of key metabolic genes by TH in the liver.	Cholesterol Esters	40-58	sterol O-acyltransferase 2	Homo sapiens	6-11
23711919-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	100-138
23711919-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	140-145
23711919-4	2013	Among them, 1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl PPPA derivative 7q and 1,11-O-o,o-dimethylbenzylidene-7-O-p-cyanobenzoyl PPPA derivative 7z proved to be potent ACAT2 inhibitors with unprecedented high isozyme selectivity.	1,11-o-o-methylbenzylidene-7-o-p-cyanobenzoyl pppa	12-62	sterol O-acyltransferase 2	Homo sapiens	170-175
23711919-3	2013	The new o-substituted benzylidene derivatives showed higher selectivity for ACAT2 than PPPA (1).	o-substituted benzylidene	8-33	sterol O-acyltransferase 2	Homo sapiens	76-81
23711919-4	2013	Among them, 1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl PPPA derivative 7q and 1,11-O-o,o-dimethylbenzylidene-7-O-p-cyanobenzoyl PPPA derivative 7z proved to be potent ACAT2 inhibitors with unprecedented high isozyme selectivity.	1,11-o-o,o-dimethylbenzylidene-7-o-p-cyanobenzoyl pppa	81-135	sterol O-acyltransferase 2	Homo sapiens	170-175
22155889-1	2012	Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is important for cholesterol ester synthesis and secretion.	Cholesterol Esters	71-88	sterol O-acyltransferase 2	Homo sapiens	0-45
21533611-6	2011	We report that CBD significantly upregulated the mRNAs of the enzymes sterol-O-acyl transferase (Soat2), which synthesizes cholesteryl esters, and of sterol 27-hydroxylase (Cyp27a1).	Cholesterol Esters	123-141	sterol O-acyltransferase 2	Homo sapiens	97-102
21533611-8	2011	Moreover, we found that pretreatment of the cells with the cholesterol chelating agent, methyl-beta-cyclodextrin (MBCD), reversed the CBD-induced increase in Soat2 mRNA but not in Plin2 mRNA.	Cholesterol	59-70	sterol O-acyltransferase 2	Homo sapiens	158-163
21533611-8	2011	Moreover, we found that pretreatment of the cells with the cholesterol chelating agent, methyl-beta-cyclodextrin (MBCD), reversed the CBD-induced increase in Soat2 mRNA but not in Plin2 mRNA.	methyl-beta-cyclodextrin	88-112	sterol O-acyltransferase 2	Homo sapiens	158-163
21533611-8	2011	Moreover, we found that pretreatment of the cells with the cholesterol chelating agent, methyl-beta-cyclodextrin (MBCD), reversed the CBD-induced increase in Soat2 mRNA but not in Plin2 mRNA.	Cannabidiol	134-137	sterol O-acyltransferase 2	Homo sapiens	158-163
20405839-9	2010	In contrast, the frequent cholesterol intake up-regulated the mRNA levels of intestinal Niemann-Pick C1-like 1 (NPC1L1), acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2), and microsomal triacylglycerol transport protein (MTP).	Cholesterol	26-37	sterol O-acyltransferase 2	Homo sapiens	121-166
23535327-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	100-138
23535327-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	140-145
23369538-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	100-138
23369538-0	2013	Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.	pyripyropene A	49-63	sterol O-acyltransferase 2	Homo sapiens	140-145
23369538-2	2013	We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than 1.	pyripyropene A	37-41	sterol O-acyltransferase 2	Homo sapiens	136-141
23369538-2	2013	We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than 1.	pyripyropene A	37-41	sterol O-acyltransferase 2	Homo sapiens	173-178
23369538-2	2013	We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than 1.	7-o-substituted benzoyl	61-84	sterol O-acyltransferase 2	Homo sapiens	136-141
23369538-2	2013	We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than 1.	7-o-substituted benzoyl	61-84	sterol O-acyltransferase 2	Homo sapiens	173-178
21811018-7	2011	In parallel, LXR agonists reduced cholesterol biosynthesis by 30-80% while stimulating esterification (up to 2.5-fold) and efflux (up to 2.5-fold) of cellular cholesterol by modifying hydroxymethylglutaryl-CoA reductase (HMGCR), sterol regulatory element-binding protein (SREBP-2), acyl-CoA: cholesterol acyltransferase 2 (ACAT-2), and ATP binding cassette transporter A1 (ABCA1) expression levels.	Cholesterol	159-170	sterol O-acyltransferase 2	Homo sapiens	282-321
21811018-7	2011	In parallel, LXR agonists reduced cholesterol biosynthesis by 30-80% while stimulating esterification (up to 2.5-fold) and efflux (up to 2.5-fold) of cellular cholesterol by modifying hydroxymethylglutaryl-CoA reductase (HMGCR), sterol regulatory element-binding protein (SREBP-2), acyl-CoA: cholesterol acyltransferase 2 (ACAT-2), and ATP binding cassette transporter A1 (ABCA1) expression levels.	Cholesterol	159-170	sterol O-acyltransferase 2	Homo sapiens	323-329
19759374-8	2009	ACAT2 activity was significantly associated with hepatic total cholesterol, plasma V+IDLC cholesterol, and atherosclerosis.	Cholesterol	63-74	sterol O-acyltransferase 2	Homo sapiens	0-5
19759374-8	2009	ACAT2 activity was significantly associated with hepatic total cholesterol, plasma V+IDLC cholesterol, and atherosclerosis.	Cholesterol	90-101	sterol O-acyltransferase 2	Homo sapiens	0-5
19759374-9	2009	CONCLUSIONS: Atheroprotective effects of estrogen therapy may be related to reduced hepatic secretion of ACAT2-derived cholesteryl esters in plasma lipoproteins.	Cholesterol Esters	119-137	sterol O-acyltransferase 2	Homo sapiens	105-110