PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34004138-5	2021	Rather than altering the DNA damage response to exogenous stimuli, such as X-irradiation or etoposide treatment, mutant CARD14 increased DNA double-strand breaks under conditions of replication stress.	Etoposide	92-101	caspase recruitment domain family member 14	Homo sapiens	120-126
34409641-11	2021	Gene analysis demonstrated CARD14 gene variants associated with RA, CD, AS, or PPP in four patients.	Cadmium	68-70	caspase recruitment domain family member 14	Homo sapiens	27-33
33316896-5	2020	In human keratinocytes, UBAC1 negatively regulates the NF-kappaF-activating capacity of CARMA2sh following exposure to poly (I:C), an agonist of Toll-like Receptor 3.	Poly I-C	119-129	caspase recruitment domain family member 14	Homo sapiens	88-94
31994212-0	2020	Coexisting mutations in CARD14 and NUTD15 detected in a young female with azathioprine hypersensitivity syndrome manifested as acute generalized exanthematous pustulosis.	Azathioprine	74-86	caspase recruitment domain family member 14	Homo sapiens	24-30
31486084-0	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	Poly I-C	49-58	caspase recruitment domain family member 14	Homo sapiens	0-6
31486084-0	2020	CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes.	Poly I-C	49-58	caspase recruitment domain family member 14	Homo sapiens	7-13
31486084-3	2020	We also show that CARMA2 and TANK are individually required to activate the nuclear factor kappaB (NF-kappaB) response following exposure to polyinosinic-polycytidylic (poly [I:C]), an agonist of toll-like receptor 3.	polyinosinic-polycytidylic	141-167	caspase recruitment domain family member 14	Homo sapiens	18-24
31486084-3	2020	We also show that CARMA2 and TANK are individually required to activate the nuclear factor kappaB (NF-kappaB) response following exposure to polyinosinic-polycytidylic (poly [I:C]), an agonist of toll-like receptor 3.	Poly I-C	169-179	caspase recruitment domain family member 14	Homo sapiens	18-24
27071417-8	2016	Inhibition of MALT1 with mepazine reduced CARD14(E138A)-induced expression of specific psoriasis-associated transcripts in keratinocytes.	mepazine	25-33	caspase recruitment domain family member 14	Homo sapiens	42-48
24044214-3	2013	And then,14-3-3beta dimeration buffer were incubated with different does recombinant PrP and 250 micromol/L PrP106-126 peptide, 14-3-3beta dimer and polymer were detected by above methods.	14-3-3beta	9-19	caspase recruitment domain family member 14	Homo sapiens	85-88
23216755-5	2012	Using western blot analysis and apoptosis assays of cultured cells, we found that the overexpression of Hsp70 by transfection or the activation of Hsp70 by geldanamycin selectively mediated the degradation of cytosolic PrPs and restored cytosolic PrP-induced cytotoxicity.	geldanamycin	156-168	caspase recruitment domain family member 14	Homo sapiens	219-222
19594024-9	2009	Alizarin red staining was performed on PRP group 14 days after culture to detect the formation of calcium nodule.	alizarin	0-12	caspase recruitment domain family member 14	Homo sapiens	39-42
19594024-9	2009	Alizarin red staining was performed on PRP group 14 days after culture to detect the formation of calcium nodule.	Calcium	98-105	caspase recruitment domain family member 14	Homo sapiens	39-42
19594024-12	2009	MTT method revealed the absorbance value of PRP group at 1, 2, 3, 4 and 5 days was 0.137 +/- 0.015, 0.219 +/- 0.023, 0.367 +/- 0.031, 0.586 +/- 0.039 and 0.948 +/- 0.046, respectively, and in the control group, it was 0.081 +/- 0.009, 0.115 +/- 0.012, 0.162 +/- 0.017, 0.242 +/- 0.025 and 0.356 +/- 0.032, respectively, suggesting there were significant differences between two groups (P < 0.01).	monooxyethylene trimethylolpropane tristearate	0-3	caspase recruitment domain family member 14	Homo sapiens	44-47
19594024-15	2009	At 14 days after osteogenic induction, Alizarin red staining showed the formation of calcium nodule in PRP group.	alizarin	39-51	caspase recruitment domain family member 14	Homo sapiens	103-106
19594024-15	2009	At 14 days after osteogenic induction, Alizarin red staining showed the formation of calcium nodule in PRP group.	Calcium	85-92	caspase recruitment domain family member 14	Homo sapiens	103-106
17995926-6	2008	Dantrolene was shown to protect NT2 rho+ from PrP(106-126)-induced cell death, demonstrating the involvement of Ca2+ release through ER ryanodine receptors.	Dantrolene	0-10	caspase recruitment domain family member 14	Homo sapiens	46-49
16891373-2	2006	Here we analyze three usages of flexible linkers: 1), intramolecular binding of proline-rich peptides (PRPs) to SH3 domains for kinase regulation; 2), intramolecular binding of PRP for increasing the folding stability of SH3 domains; and 3), covalent linking of PRPs and other ligands for high-affinity bivalent binding.	Proline	80-87	caspase recruitment domain family member 14	Homo sapiens	103-106
12926375-0	2003	Synthesis and acid-base properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-).	(1h-benzimidazol-2-yl-methyl)phosphonate	38-78	caspase recruitment domain family member 14	Homo sapiens	80-85
12926375-7	2003	Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2%.	Hydrogen	164-172	caspase recruitment domain family member 14	Homo sapiens	245-250
12926375-7	2003	Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2%.	Organophosphonates	224-235	caspase recruitment domain family member 14	Homo sapiens	245-250
12926375-7	2003	Comparisons with acidity constants taken from the literature show that this latter pKa value is far too large and this allows the conclusion that an intramolecular hydrogen bond is formed between the (N-1/N-3)H site and the phosphonate group of Bimp2-; the formation degree of this hydrogen-bonded isomer is estimated to be 98 +/- 2%.	Hydrogen	282-290	caspase recruitment domain family member 14	Homo sapiens	245-250
33804147-3	2021	The pathogenesis of psoriasis may involve the dysfunction of indoleamine 2,3-dioxygenase 2 or of UBA domain containing 1-mediated regulation of CARD14/CARMA2sh.	UBP 310	97-100	caspase recruitment domain family member 14	Homo sapiens	144-150
33804147-3	2021	The pathogenesis of psoriasis may involve the dysfunction of indoleamine 2,3-dioxygenase 2 or of UBA domain containing 1-mediated regulation of CARD14/CARMA2sh.	UBP 310	97-100	caspase recruitment domain family member 14	Homo sapiens	151-157
30144153-0	2019	Terbinafine-induced generalized pustular psoriasis in a patient carrying CARD14 mutation.	Terbinafine	0-11	caspase recruitment domain family member 14	Homo sapiens	73-79
16809610-7	2006	Evaluation of changes in gene expression profile indicates that EGCG treatment activates distinct pathways of growth arrest and apoptosis in MM cells by inducing the expression of death-associated protein kinase 2, the initiators and mediators of death receptor-dependent apoptosis (Fas ligand, Fas, and caspase 4), p53-like proteins (p73, p63), positive regulators of apoptosis and NF-kappaB activation (CARD10, CARD14), and cyclin-dependent kinase inhibitors (p16 and p18).	epigallocatechin gallate	64-68	caspase recruitment domain family member 14	Homo sapiens	413-419
14966966-0	2004	Metal ion-binding properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-) in aqueous solution.	Metals	0-5	caspase recruitment domain family member 14	Homo sapiens	74-79
14966966-0	2004	Metal ion-binding properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-) in aqueous solution.	(1h-benzimidazol-2-yl-methyl)phosphonate	32-72	caspase recruitment domain family member 14	Homo sapiens	74-79
14966966-6	2004	The fact that for Bimp2- the metal ion affinity of the two binding sites, N3 and PO3(2-), can be calculated independently, i.e., the corresponding micro stability constants become known, allows us to present for the first time a method for the quantification of the chelate effect solely based on comparisons of stability constants which carry the same dimensions.	Metals	29-34	caspase recruitment domain family member 14	Homo sapiens	18-23
10934164-5	2000	PrP(M) contained an aberrant glycan at residue 197 and generated an increased quantity of truncated fragments.	Polysaccharides	29-35	caspase recruitment domain family member 14	Homo sapiens	0-3
34080218-0	2021	Case of annular pustular psoriasis/circinate erythematous psoriasis induced by hydroxychloroquine in a patient with systemic lupus erythematosus: Possible association with CARD-14 mutation.	Hydroxychloroquine	79-97	caspase recruitment domain family member 14	Homo sapiens	172-179
34075616-0	2021	CARD14-associated papulosquamous eruption (CAPE) in a toddler responding to treatment with acitretin.	Acitretin	91-100	caspase recruitment domain family member 14	Homo sapiens	0-6
34271060-8	2022	The T variant destroys a functional cytosine-phosphate-guanine site, resulting in reduced cytosine-phosphate-guanine methylation at this site (but not neighboring sites) in TT and CT compared with CC primary human keratinocytes and Mechanisms of Progression of Atopic Dermatitis to Asthma in Children children"s skin samples, and rs11652075 increases CARD14 expression in an allele-specific fashion.	cytosine-phosphate-guanine	90-116	caspase recruitment domain family member 14	Homo sapiens	351-357