PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34601222-8 2021 METHODS AND RESULTS: Murine macrophages were incubated with 28 muM 7beta-hydroxycholesterol in absence and presence of 1-20 muMu asaronic acid for up to 24 h. Nontoxic asaronic acid in macrophage diminished the activation of the ER stress sensors of ATF6, IRE1 and PERK stimulated by 7beta-hydroxycholesterol. cholest-5-en-3 beta,7 alpha-diol 67-91 activating transcription factor 6 Mus musculus 250-254 34979291-9 2021 Tunicamycin administration caused significant increase of the expression level of genes related to ER stress and UPR, such as CHOP, Grp78 and ATF6, but the berberine pre-treatment could significantly downregulate the expression level of these genes. Tunicamycin 0-11 activating transcription factor 6 Mus musculus 142-146 34979291-9 2021 Tunicamycin administration caused significant increase of the expression level of genes related to ER stress and UPR, such as CHOP, Grp78 and ATF6, but the berberine pre-treatment could significantly downregulate the expression level of these genes. Berberine 156-165 activating transcription factor 6 Mus musculus 142-146 34525858-3 2021 Besides, similar to PBA, D4F inhibited gly-HDL-induced ER stress response activation evaluated through the decreased PERK and eIF2alpha phosphorylation, together with reduced ATF6 nuclear translocation as well as the downregulation of GRP78 and CHOP. Glycine 39-42 activating transcription factor 6 Mus musculus 175-179 34698990-5 2021 RESULTS: Levels of ATF6 and phosphorylated PERK and IRE1 increased in a dose-dependent manner in MC3T3-E1 cells treated with 10-8, 10-6, and 10-4 M Dex, compared to the control group (P < 0.05). Dexamethasone 148-151 activating transcription factor 6 Mus musculus 19-23 34698990-9 2021 CONCLUSIONS: High doses of Dex induce CHOP expression by promoting calcium ion influx-dependent induction of ATF6, phosphorylated PERK and phosphorylated IRE1, which induce endoplasmic reticulum stress-mediated apoptosis in osteoblasts. Dexamethasone 27-30 activating transcription factor 6 Mus musculus 109-113 34698990-9 2021 CONCLUSIONS: High doses of Dex induce CHOP expression by promoting calcium ion influx-dependent induction of ATF6, phosphorylated PERK and phosphorylated IRE1, which induce endoplasmic reticulum stress-mediated apoptosis in osteoblasts. Calcium 67-74 activating transcription factor 6 Mus musculus 109-113 34601222-8 2021 METHODS AND RESULTS: Murine macrophages were incubated with 28 muM 7beta-hydroxycholesterol in absence and presence of 1-20 muMu asaronic acid for up to 24 h. Nontoxic asaronic acid in macrophage diminished the activation of the ER stress sensors of ATF6, IRE1 and PERK stimulated by 7beta-hydroxycholesterol. 2,4,5-Trimethoxybenzoic acid 168-181 activating transcription factor 6 Mus musculus 250-254 34601222-8 2021 METHODS AND RESULTS: Murine macrophages were incubated with 28 muM 7beta-hydroxycholesterol in absence and presence of 1-20 muMu asaronic acid for up to 24 h. Nontoxic asaronic acid in macrophage diminished the activation of the ER stress sensors of ATF6, IRE1 and PERK stimulated by 7beta-hydroxycholesterol. cholest-5-en-3 beta,7 alpha-diol 284-308 activating transcription factor 6 Mus musculus 250-254 16601230-0 2006 Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Tamoxifen 132-141 activating transcription factor 6 Mus musculus 160-164 16601230-5 2006 To examine whether ATF6 protects the myocardium from I/R injury in the heart, we generated transgenic (TG) mice featuring cardiac-restricted expression of a novel tamoxifen-activated form of ATF6, ATF6-MER. Tamoxifen 163-172 activating transcription factor 6 Mus musculus 191-195 16601230-5 2006 To examine whether ATF6 protects the myocardium from I/R injury in the heart, we generated transgenic (TG) mice featuring cardiac-restricted expression of a novel tamoxifen-activated form of ATF6, ATF6-MER. Tamoxifen 163-172 activating transcription factor 6 Mus musculus 191-195 16601230-6 2006 When NTG and ATF6-MER TG mice were treated with or without tamoxifen for 5 days, only the hearts from the tamoxifen-treated TG mice exhibited increased levels of many ER stress-inducible mRNAs and proteins; for example, GRP78 and GRP94 transcript levels were increased by 8- and 15-fold, respectively. Tamoxifen 59-68 activating transcription factor 6 Mus musculus 13-17 16601230-6 2006 When NTG and ATF6-MER TG mice were treated with or without tamoxifen for 5 days, only the hearts from the tamoxifen-treated TG mice exhibited increased levels of many ER stress-inducible mRNAs and proteins; for example, GRP78 and GRP94 transcript levels were increased by 8- and 15-fold, respectively. Tamoxifen 106-115 activating transcription factor 6 Mus musculus 13-17 11805088-0 2002 Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. Nitric Oxide 0-12 activating transcription factor 6 Mus musculus 118-122 33767628-5 2021 The results clearly showed that DSS exposure caused excessive ER stress evidenced by a markedly increase of GRP78 and CHOP expression, and then activated the ER stress sensors PERK, IRE1, ATF6 and their respective signaling pathways, followed by upregulated caspases12 and lowered Bcl-2/Bax ratio. Dextran Sulfate 32-35 activating transcription factor 6 Mus musculus 188-192 34601222-8 2021 METHODS AND RESULTS: Murine macrophages were incubated with 28 muM 7beta-hydroxycholesterol in absence and presence of 1-20 muMu asaronic acid for up to 24 h. Nontoxic asaronic acid in macrophage diminished the activation of the ER stress sensors of ATF6, IRE1 and PERK stimulated by 7beta-hydroxycholesterol. 2,4,5-Trimethoxybenzoic acid 129-142 activating transcription factor 6 Mus musculus 250-254 34623328-8 2021 Mice deficient in RNF186 or ATF6 demonstrated a reduced UPR in colonic tissues, increased weight loss, and less effective clearance of bacteria with dextran sodium sulfate-induced injury and upon oral challenge with Salmonella Typhimurium. dextran sodium sulfate 149-171 activating transcription factor 6 Mus musculus 28-32 34129155-2 2021 On the other hand, treatment with BFA induces the activation of CREB3, the protein structure of which is similar to that of ATF6. Brefeldin A 34-37 activating transcription factor 6 Mus musculus 124-128 34759791-8 2021 Additionally, TM treatment resulted in markedly increased PERK, GRP78, ATF6, XBP1, and CHOP protein expression levels. Tunicamycin 14-16 activating transcription factor 6 Mus musculus 71-75 34262465-6 2021 We found that chronic alcohol exposure-induced hepatic CHOP and ATF6 activation were enhanced in TLR9 KO mice. Alcohols 22-29 activating transcription factor 6 Mus musculus 64-68 34091186-7 2021 Then, As or/and Sb induced ERS and triggered the ER apoptotic pathway by activating unfolded protein response (UPR)-associated genes ((PERK, ATF6, IRE1, XBP1, JNK, GRP78), and apoptosis-related genes (Caspase12, Caspase3, p53, CHOP). Arsenic 6-8 activating transcription factor 6 Mus musculus 141-145 34091186-7 2021 Then, As or/and Sb induced ERS and triggered the ER apoptotic pathway by activating unfolded protein response (UPR)-associated genes ((PERK, ATF6, IRE1, XBP1, JNK, GRP78), and apoptosis-related genes (Caspase12, Caspase3, p53, CHOP). Antimony 16-18 activating transcription factor 6 Mus musculus 141-145 34254745-0 2021 Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PERK signaling pathways. Melatonin 0-9 activating transcription factor 6 Mus musculus 88-92 34254745-8 2021 Pretreatment with melatonin alleviated heat-induced apoptosis by inhibiting the Atf6 and Perk signaling pathways. Melatonin 18-27 activating transcription factor 6 Mus musculus 80-84 34254745-11 2021 In conclusion, our results demonstrated that ATF6 and PERK are important mediators for heat-induced apoptosis, which can be prevented by melatonin treatment. Melatonin 137-146 activating transcription factor 6 Mus musculus 45-49 34262465-7 2021 By using primary hepatocytes and AML-12 cells, we confirmed that TLR9 activation by CpG ODN administration significantly ameliorated acetaldehyde-induced cell injury via suppressing ATF6-CHOP signaling. Acetaldehyde 133-145 activating transcription factor 6 Mus musculus 182-186 33354763-8 2021 17-beta-estradiol reduced expression of CHOP, while cytisine exposure reduced 6-OHDA-mediated nuclear translocation of two other ER stress proteins, activating transcription factor 6 (ATF6) and x-box binding protein 1 (XBP1), but not CHOP. cytisine 52-60 activating transcription factor 6 Mus musculus 149-182 35609415-8 2022 Mechanistically, ATF6 and CTH increased H2S generation and autophagy-related proteins. Deuterium 40-43 activating transcription factor 6 Mus musculus 17-21 33985576-8 2021 Furthermore, the expression levels of unfolded protein response genes, C/EBP homologous protein (CHOP), and activating transcription factor 6 (ATF6) were upregulated in vitamin D3-treated organoids. Cholecalciferol 169-179 activating transcription factor 6 Mus musculus 108-141 33985576-8 2021 Furthermore, the expression levels of unfolded protein response genes, C/EBP homologous protein (CHOP), and activating transcription factor 6 (ATF6) were upregulated in vitamin D3-treated organoids. Cholecalciferol 169-179 activating transcription factor 6 Mus musculus 143-147 34026562-5 2021 Transcriptome analysis showed upregulation of the genes involved in the unfolded protein response (UPR), including Bip, CHOP, ATF4 and ATF6, in cells treated with Delta9-THC. Dronabinol 163-173 activating transcription factor 6 Mus musculus 135-139 32647341-9 2021 We analyzed the hallmarks of ER stress in heart tissues, and revealed that ZNS administration significantly decreased the protein levels of GRP78, XBP-1s, ATF6, PERK, ATF4, and CHOP, and elevated Hrd1 protein. Zonisamide 75-78 activating transcription factor 6 Mus musculus 155-159 35413383-5 2022 Importantly, 3-Ac-DON enhanced the mRNA abundances of ER stress-related indicators, such as BIP, IRE1A, ATF6, XBP-1, EIF2A, ATF4, and CHOP, which were abolished by 4-PBA, indicating the inhibiting effects of ER stress by 4-PBA in the spleen. 3-acetyldeoxynivalenol 13-21 activating transcription factor 6 Mus musculus 104-108 35457433-0 2022 Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2alpha-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells. raiser 0-15 activating transcription factor 6 Mus musculus 72-76 35457433-10 2022 After pretreated with ISRIB, the inhibitor of eIF2alpha phosphorylation, the elevated expression of GRP78, phosphorylated-eIF2alpha, ATF4, ATF6, CHOP and Bim was down to normal level accordingly. 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide 22-27 activating transcription factor 6 Mus musculus 139-143 35289326-3 2022 Here we demonstrated that in the liver tissues and Kupffer cells (KCs) of DM patients and STZ-induced hyperglycemic mice, the ER stress-ATF6-CHOP signaling pathway is activated. Streptozocin 90-93 activating transcription factor 6 Mus musculus 136-140 33684391-10 2021 CIH also significantly increased blood pressure, induced hyperlipidemia, as well as the expression of ERS protein activating transcription factor-6 (ATF6) and aortic vascular smooth muscle cell proliferation. cih 0-3 activating transcription factor 6 Mus musculus 114-147 33684391-10 2021 CIH also significantly increased blood pressure, induced hyperlipidemia, as well as the expression of ERS protein activating transcription factor-6 (ATF6) and aortic vascular smooth muscle cell proliferation. cih 0-3 activating transcription factor 6 Mus musculus 149-153 33746115-13 2021 The contents of CHOP and cleaved ATF6 were decreased in metformin-treated 24 mo. Metformin 56-65 activating transcription factor 6 Mus musculus 33-37 33354763-8 2021 17-beta-estradiol reduced expression of CHOP, while cytisine exposure reduced 6-OHDA-mediated nuclear translocation of two other ER stress proteins, activating transcription factor 6 (ATF6) and x-box binding protein 1 (XBP1), but not CHOP. cytisine 52-60 activating transcription factor 6 Mus musculus 184-188 33354763-8 2021 17-beta-estradiol reduced expression of CHOP, while cytisine exposure reduced 6-OHDA-mediated nuclear translocation of two other ER stress proteins, activating transcription factor 6 (ATF6) and x-box binding protein 1 (XBP1), but not CHOP. Oxidopamine 78-84 activating transcription factor 6 Mus musculus 149-182 33354763-8 2021 17-beta-estradiol reduced expression of CHOP, while cytisine exposure reduced 6-OHDA-mediated nuclear translocation of two other ER stress proteins, activating transcription factor 6 (ATF6) and x-box binding protein 1 (XBP1), but not CHOP. Oxidopamine 78-84 activating transcription factor 6 Mus musculus 184-188 33354763-9 2021 Taken together, these data show that cytisine and 17-beta-estradiol work in combination to inhibit all three arms (ATF6, XBP1 and CHOP) of apoptotic ER stress signaling in DA neurons, which can explain the neuroprotective effect of low dose cytisine in female mice. cytisine 37-45 activating transcription factor 6 Mus musculus 115-119 33354763-9 2021 Taken together, these data show that cytisine and 17-beta-estradiol work in combination to inhibit all three arms (ATF6, XBP1 and CHOP) of apoptotic ER stress signaling in DA neurons, which can explain the neuroprotective effect of low dose cytisine in female mice. Estradiol 50-67 activating transcription factor 6 Mus musculus 115-119 33354763-9 2021 Taken together, these data show that cytisine and 17-beta-estradiol work in combination to inhibit all three arms (ATF6, XBP1 and CHOP) of apoptotic ER stress signaling in DA neurons, which can explain the neuroprotective effect of low dose cytisine in female mice. Dopamine 172-174 activating transcription factor 6 Mus musculus 115-119 33434534-10 2021 Mechanistically, glycerol injection triggered ER stress characterized by activated IRE1, PERK, and ATF6 signaling pathways, and induced mitochondrial dysfunction supported by ultrastructural damage, energy metabolic derangement, and excessive mitochondrial fission (upregulated DRP1/downregulated OPA1). Glycerol 17-25 activating transcription factor 6 Mus musculus 99-103 33671902-5 2021 Treatment with BZ and CFZ induced endoplasmic reticulum (ER) stress, as indicated by an increase in eIF2alpha phosphorylation and the expression of ER stress-associated proteins, including GRP78, ATF6alpha, ATF4, XBP1, and CCAAT/enhancer-binding protein homologous protein. Bortezomib 15-17 activating transcription factor 6 Mus musculus 196-205 33288253-6 2021 Furthermore, MC-LR exposure promoted cleavage of activating transcription factor 6 (ATF6, 50kd), inositol-requiring enzyme 1 (Ire1) expression, phosphorylation of IRE1, mitogen-activated protein kinase 5 (Map3k5) and Ddit3 expression, which was accompanied by the upregulation of death receptor 5 (Dr5) and active-caspase-3, and a decrease in Bcl-2 expression. mc-lr 13-18 activating transcription factor 6 Mus musculus 49-82 33288253-6 2021 Furthermore, MC-LR exposure promoted cleavage of activating transcription factor 6 (ATF6, 50kd), inositol-requiring enzyme 1 (Ire1) expression, phosphorylation of IRE1, mitogen-activated protein kinase 5 (Map3k5) and Ddit3 expression, which was accompanied by the upregulation of death receptor 5 (Dr5) and active-caspase-3, and a decrease in Bcl-2 expression. mc-lr 13-18 activating transcription factor 6 Mus musculus 84-88 33671902-5 2021 Treatment with BZ and CFZ induced endoplasmic reticulum (ER) stress, as indicated by an increase in eIF2alpha phosphorylation and the expression of ER stress-associated proteins, including GRP78, ATF6alpha, ATF4, XBP1, and CCAAT/enhancer-binding protein homologous protein. carfilzomib 22-25 activating transcription factor 6 Mus musculus 196-205 33557643-2 2021 Previously, we have found that psoralen induced hepatocytes apoptosis via PERK and ATF6 related ER stress pathways in vitro. Ficusin 31-39 activating transcription factor 6 Mus musculus 83-87 33566227-6 2021 Upon DEX intervention which induces the unfolded protein response (UPR), the expression levels of BIP, ATF6, IRE1, and PERK increased in the MIN6 cells, both in concentration and time-dependent manner. Dexamethasone 5-8 activating transcription factor 6 Mus musculus 103-107 33467546-8 2021 Empagliflozin significantly decreased the expression of ER stress molecules Grp78, Ire1alpha, Xbp1, Elf2alpha, Atf4, Atf6, Chop, P62(Sqstm1) and Grp94; whilst activating autophagy via increased AMPK phosphorylation, decreased mTOR and increased LC3B expression. empagliflozin 0-13 activating transcription factor 6 Mus musculus 117-121 32998266-7 2020 Furthermore, idebenone significantly reduced the expression of the ER stress markers C/EBP homologous protein (CHOP), activating transcription factor 6 (ATF6) and X-box binding protein-1 (XBP-1) at both mRNA and protein levels. idebenone 13-22 activating transcription factor 6 Mus musculus 118-151 33323915-12 2020 Four endoplasmic reticulum stress markers, ATF-6alpha, Bip, CHOP, and spliced xBP1, were significantly increased in palmitate-treated podocytes compared with control podocytes. Palmitates 116-125 activating transcription factor 6 Mus musculus 43-53 32998266-7 2020 Furthermore, idebenone significantly reduced the expression of the ER stress markers C/EBP homologous protein (CHOP), activating transcription factor 6 (ATF6) and X-box binding protein-1 (XBP-1) at both mRNA and protein levels. idebenone 13-22 activating transcription factor 6 Mus musculus 153-157 32593710-9 2020 Furthermore, BPA caused mild steatosis in OVX CBPA females, increasing the hepatic total lipids and mRNAs for Srebf1, Scd1, Hspa5, Hyou1 and Atf6. bisphenol A 13-16 activating transcription factor 6 Mus musculus 141-145 32189544-9 2020 Furthermore, 50mg/kg metformin markedly down-regulated the expression of proinflammatory cytokines (TNF-alpha and IL-1beta) and ER stress related genes (ATF4, ATF6, XBP1, Grp78 and CHOP) in rotenone-induced PD mice. Metformin 21-30 activating transcription factor 6 Mus musculus 159-163 32592071-6 2020 The ATF6 inhibitor, AEBSF, blocked the upregulation of cTGF and both the angiogenesis and arteriogenesis, resulting in abolition of the reduced infarct size and protection of cardiac function in the sFRP2 TG mouse following permanent CAO. 4-(2-aminoethyl)benzenesulfonylfluoride 20-25 activating transcription factor 6 Mus musculus 4-8 31827236-4 2020 SPHK1 deficiency alleviated APAP-induced endoplasmic reticulum (ER) stress by affecting the phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha), levels of activating transcription factor 4 (ATF4), and activation of activating transcription factor 6 (ATF6). Acetaminophen 28-32 activating transcription factor 6 Mus musculus 355-388 31827236-4 2020 SPHK1 deficiency alleviated APAP-induced endoplasmic reticulum (ER) stress by affecting the phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha), levels of activating transcription factor 4 (ATF4), and activation of activating transcription factor 6 (ATF6). Acetaminophen 28-32 activating transcription factor 6 Mus musculus 390-394 31827236-7 2020 Supplementation with exogenous S1P significantly reversed the activation of the PERK-eIF2alpha-ATF4 pathway and ATF6 during ER stress as well as the activation of GSK3beta, ASK1, and JNK during MPT. sphingosine 1-phosphate 31-34 activating transcription factor 6 Mus musculus 112-116 32724824-6 2020 Cells infected with Ad-LacZ exhibited a rapid and strong activation of ATF6 and p38, peaking at 3 h after TM exposure. ad-lacz 20-27 activating transcription factor 6 Mus musculus 71-75 32724824-6 2020 Cells infected with Ad-LacZ exhibited a rapid and strong activation of ATF6 and p38, peaking at 3 h after TM exposure. Tunicamycin 106-108 activating transcription factor 6 Mus musculus 71-75 32323766-13 2020 Furthermore, qPCR showed that the insulin mRNA expression was significantly increased 24 h after PA treatment in cells transfected with ATF6-siRNA compared with the negative control group. Palmitates 97-99 activating transcription factor 6 Mus musculus 136-140 31580970-12 2019 In addition, our data indicated that CACNA1H may play a role in alleviating DOX-induced cardiotoxicity by reducing the severity of ER stress because the use of ABT-639 significantly changed ER stress-related proteins, including p-PERK, PERK, CHOP, GRP78, ATF6, and ATF4. Doxorubicin 76-79 activating transcription factor 6 Mus musculus 255-259 32431525-8 2020 Importantly, MAM quantity was positively associated with mitochondrial function and tended to negatively correlate with the ERS branch, ATF6. methylazoxymethanol 13-16 activating transcription factor 6 Mus musculus 136-140 32373236-0 2020 Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-alpha pathway-dependent fatty acid oxidation. Amino Acids, Branched-Chain 0-26 activating transcription factor 6 Mus musculus 103-107 32373236-0 2020 Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-alpha pathway-dependent fatty acid oxidation. Fatty Acids 137-147 activating transcription factor 6 Mus musculus 103-107 32312941-8 2020 Meanwhile, quercetin up-regulates SIRT1 protein expression and inhibits the expression of ER signaling pathway-related proteins (PERK, IRE-1alpha, ATF6, eIF2alpha, BIP and PDI). Quercetin 11-20 activating transcription factor 6 Mus musculus 147-151 31894849-8 2020 Cisplatin-induced AKI triggered multiple signal mediators of endoplasmic reticulum (ER) stress including PERK, ATF6 and IRE1 pathway, as well as CHOP, GRP78, p-JNK and caspase 12 proteins. Cisplatin 0-9 activating transcription factor 6 Mus musculus 111-115 31580970-12 2019 In addition, our data indicated that CACNA1H may play a role in alleviating DOX-induced cardiotoxicity by reducing the severity of ER stress because the use of ABT-639 significantly changed ER stress-related proteins, including p-PERK, PERK, CHOP, GRP78, ATF6, and ATF4. 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-ylcarbonyl)benzenesulfonamide 160-167 activating transcription factor 6 Mus musculus 255-259 31176760-7 2019 Naringenin-induced cholesterol efflux was modulated by treatment with ER stress inhibitor 4-phenylbutyric acid, inducer tunicamycin and ATF6 overexpression in RAW264.7 and/or THP-1 cells, which suggested the naringenin functions were mediated through inhibiting ER stress-ATF6 pathway. Cholesterol 19-30 activating transcription factor 6 Mus musculus 136-140 31639405-0 2019 Salubrinal attenuates nitric oxide mediated PERK:IRE1alpha: ATF-6 signaling and DNA damage in neuronal cells. Nitric Oxide 22-34 activating transcription factor 6 Mus musculus 60-65 31639405-4 2019 The rotenone treatment to neuro2a cells also triggered the ER stress induced up regulation of various signaling factors of unfolded protein response involving pPERK, ATF4, p-IRE1alpha, XBP-1 and ATF-6. Rotenone 4-12 activating transcription factor 6 Mus musculus 195-200 31639405-10 2019 Further, salubrinal treatment attenuates the nitric oxide induced ER stress axis PERK:IRE1alpha:ATF-6 and inhibits the DNA damage and neuronal apoptosis. salubrinal 9-19 activating transcription factor 6 Mus musculus 96-101 31639405-10 2019 Further, salubrinal treatment attenuates the nitric oxide induced ER stress axis PERK:IRE1alpha:ATF-6 and inhibits the DNA damage and neuronal apoptosis. Nitric Oxide 45-57 activating transcription factor 6 Mus musculus 96-101 31650454-11 2019 The expression of ER stress marker proteins, including GRP78, CHOP, ATF6, p-JNK, and XBP-1, was upregulated in the stress group; however, GHRL treatment significantly suppressed the activation of ER stress in the testes. Ghrelin 138-142 activating transcription factor 6 Mus musculus 68-72 31408662-9 2019 Furthermore, VSMCs derived from IMD-/- mice showed increased cell proliferation and dramatically elevated levels of glucose regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), ATF6 mRNA under PDGF-BB treatment compared to WT mice-derived VSMCs. vsmcs 13-18 activating transcription factor 6 Mus musculus 196-200 31736398-7 2019 Mercury activates the PERK/eIF2alpha branch during the first 48 h. Meanwhile, the activation of PERK/ATF-4 branch allowed for ATF-4, ATF-6, and IRE1alpha pathways to enhance GADD-153. Mercury 0-7 activating transcription factor 6 Mus musculus 133-138 31176760-7 2019 Naringenin-induced cholesterol efflux was modulated by treatment with ER stress inhibitor 4-phenylbutyric acid, inducer tunicamycin and ATF6 overexpression in RAW264.7 and/or THP-1 cells, which suggested the naringenin functions were mediated through inhibiting ER stress-ATF6 pathway. naringenin 208-218 activating transcription factor 6 Mus musculus 136-140 31176760-10 2019 Naringenin decreased GRP78, XBP-1 and nuclear ATF6 levels in peritoneal macrophage and aorta and reduced atherosclerotic lesion at aortic root, but reversed by tunicamycin. naringenin 0-10 activating transcription factor 6 Mus musculus 46-50 31176760-11 2019 These confirmed participation of ER stress-ATF6 in naringenin efficacy. naringenin 51-61 activating transcription factor 6 Mus musculus 43-47 31176760-12 2019 Finally, we found naringenin promoted AKT phosphorylation; PI3K inhibitor LY294002 treatment increased nuclear ATF6 and reduced naringenin-enhanced ABCA1 expression and cholesterol efflux. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 74-82 activating transcription factor 6 Mus musculus 111-115 31176760-13 2019 We concluded naringenin as a regulator for cholesterol efflux, and the regulation was mediated by ATF6 branch of ER stress and PI3K/AKT pathway. naringenin 13-23 activating transcription factor 6 Mus musculus 98-102 31176760-13 2019 We concluded naringenin as a regulator for cholesterol efflux, and the regulation was mediated by ATF6 branch of ER stress and PI3K/AKT pathway. Cholesterol 43-54 activating transcription factor 6 Mus musculus 98-102 31199999-7 2019 PRMT1 knockdown attenuated high glucose-induced ER stress and apoptosis by inactivating PERK and ATF6, but not IRE1alpha. Glucose 32-39 activating transcription factor 6 Mus musculus 97-101 31199999-10 2019 Specifically, inhibition of ATF6, but not PERK blocked PRMT1-induced EMT in high-glucose-treatment HK2 cells. Glucose 81-88 activating transcription factor 6 Mus musculus 28-32 30539387-8 2019 The expressions of p-P38, PERK, IRE1, ATF6, and MCP-1 in Nthy-ori-3-1 cells treated with iodine at abnormal concentrations were all significantly higher than those in cells treated with iodine at normal concentration. Iodine 89-95 activating transcription factor 6 Mus musculus 38-42 31176760-0 2019 Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages. Cholesterol 18-29 activating transcription factor 6 Mus musculus 113-117 31176760-0 2019 Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages. naringenin 40-50 activating transcription factor 6 Mus musculus 113-117 31176760-3 2019 Clinical data revealed that ATF6 expression was associated with plasma cholesterol level. Cholesterol 71-82 activating transcription factor 6 Mus musculus 28-32 31176760-6 2019 Naringenin inhibited the cleaved ATF6 nuclear translocation and its target GRP78 and XBP-1 expressions. naringenin 0-10 activating transcription factor 6 Mus musculus 33-37 31176760-7 2019 Naringenin-induced cholesterol efflux was modulated by treatment with ER stress inhibitor 4-phenylbutyric acid, inducer tunicamycin and ATF6 overexpression in RAW264.7 and/or THP-1 cells, which suggested the naringenin functions were mediated through inhibiting ER stress-ATF6 pathway. naringenin 0-10 activating transcription factor 6 Mus musculus 136-140 30639234-10 2019 Taken together, these findings suggest that ATF6alpha deranges fatty acid metabolism in PTCs, which leads to lipotoxicity-mediated apoptosis and CTGF upregulation, both of which promote tubulointerstitial fibrosis. Fatty Acids 63-73 activating transcription factor 6 Mus musculus 44-53 30908665-13 2019 Antivirals and alcohol synergistically increased expression of organelle stress markers of CHOP, sXBP-1, ATF6, and GCP60. Alcohols 15-22 activating transcription factor 6 Mus musculus 105-109 30605745-5 2019 The results suggested that the mice administrated with NTHSP could significantly prevent the splenocytes apoptosis induced by gamma-radiation through block of three major types in ER apoptosis pathway: PERK-ATF4-CHOP, IRE1alpha-XBP1-CHOP, as well as ATF6-XBP1-CHOP, compared with the mice in radiation group. nthsp 55-60 activating transcription factor 6 Mus musculus 250-254 32373294-11 2019 Also, treatment with allantoin down-regulated the gene expression of glucose-regulated protein 78 (GRP78), activating transcription factor 6 (AFT6), TNFalpha, sterol regulatory element binding proteins 1c (SREBP1c), fatty acid synthase (FAS), Bax/Bcl2 ratio, caspase3, and P53. Allantoin 21-30 activating transcription factor 6 Mus musculus 107-140 32373294-11 2019 Also, treatment with allantoin down-regulated the gene expression of glucose-regulated protein 78 (GRP78), activating transcription factor 6 (AFT6), TNFalpha, sterol regulatory element binding proteins 1c (SREBP1c), fatty acid synthase (FAS), Bax/Bcl2 ratio, caspase3, and P53. Allantoin 21-30 activating transcription factor 6 Mus musculus 142-146 31118581-11 2019 Western-blot results showed that resveratrol-treated HFD mice had reduced hepatic levels of p-PERK, ATF-4 and TRIB3, and increased the levels of ATF-6, p-AKT and p-GSK3beta. Resveratrol 33-44 activating transcription factor 6 Mus musculus 145-150 31045581-9 2019 Collectively, these results demonstrate that CBA-based therapy potently inhibits the allergen-induced UPR and allergic airway disease in mice via preferential binding of the canonical transducer of the UPR, ATF6alpha. cba 45-48 activating transcription factor 6 Mus musculus 207-216 30114659-5 2018 Further studies by western blot and real-time QPCR proved that the protein and mRNA levels of GRP78, IRE-1alpha, ATF6, CHOP and caspase-12 were up-regulated after TiO2-NPs treatment, which indicates that TiO2-NPs-induced cytotoxicity is related to endoplasmic reticulum stress (ERS). titanium dioxide 163-167 activating transcription factor 6 Mus musculus 113-117 30063920-1 2018 BACKGROUND & AIMS: Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. Adenosine Monophosphate 12-15 activating transcription factor 6 Mus musculus 23-56 30063920-1 2018 BACKGROUND & AIMS: Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. Adenosine Monophosphate 12-15 activating transcription factor 6 Mus musculus 58-62 30236984-3 2018 Over expressing a dominant-negative form of ATF6 exacerbates glucose intolerance and insulin resistance. Glucose 61-68 activating transcription factor 6 Mus musculus 44-48 30236984-11 2018 In conclusion, these findings suggest that therapeutic strategies by supplementing ATF6 may be beneficial for the treatment of glucose intolerance as well as insulin resistance in the high fat induced liver metabolic damage condition. Glucose 127-134 activating transcription factor 6 Mus musculus 83-87 30728845-8 2019 Moreover, BKFE inhibited the expression of endoplasmic reticulum (ER) stress-related genes, such as BiP, phosphorylated eIF2alpha, cleaved ATF6, and spliced XBP-1, in PA-treated SV40 MES13 cells. bkfe 10-14 activating transcription factor 6 Mus musculus 139-143 30504131-11 2019 SKF96365 reduced cytoplasmic calcium concentration in ASMCs, caused mitochondrial swelling, and elevated the expression of ATF-6 and CHOP. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 0-8 activating transcription factor 6 Mus musculus 123-128 30559648-3 2018 Small-molecules able to bind DREAM, like the anti-diabetic drug repaglinide, disrupt some of the interactions with other proteins and modulate DREAM activity on Kv4 channels or on the processing of activating transcription factor 6 (ATF6). repaglinide 64-75 activating transcription factor 6 Mus musculus 198-231 30559648-3 2018 Small-molecules able to bind DREAM, like the anti-diabetic drug repaglinide, disrupt some of the interactions with other proteins and modulate DREAM activity on Kv4 channels or on the processing of activating transcription factor 6 (ATF6). repaglinide 64-75 activating transcription factor 6 Mus musculus 233-237 30300835-5 2018 In parallel, assessment of transcriptional and/or translational levels of de novo lipogenesis (DNL) and ER stress markers showed up-regulation of both fatty acid synthesis (ChREBP and SCD1) and oxidation (PPARalpha and CPT-1alpha), as well as overexpression of unfolded protein response sensors (IRE1alpha, PERK and ATF6), chaperones (GRP78 and PDIA1) and antioxidant defense (NRF2) genes at 30 days. Fatty Acids 151-161 activating transcription factor 6 Mus musculus 316-320 29607540-7 2018 Moreover, melatonin decreased palmitic acid-induced ER stress markers, CHOP, Bip, ATF-6, XBP-1, ATF-4, and PERK. Melatonin 10-19 activating transcription factor 6 Mus musculus 82-87 29894845-5 2018 Trodusquemine also prevented the Tunicamycin -induced increased arterial levels of the molecular ERS actors 78 kDa glucose-regulated protein (GRP78) and Activating Transcription Factor 6 (ATF6alpha). 3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate 0-13 activating transcription factor 6 Mus musculus 188-197 29894845-5 2018 Trodusquemine also prevented the Tunicamycin -induced increased arterial levels of the molecular ERS actors 78 kDa glucose-regulated protein (GRP78) and Activating Transcription Factor 6 (ATF6alpha). Tunicamycin 33-44 activating transcription factor 6 Mus musculus 188-197 29607540-7 2018 Moreover, melatonin decreased palmitic acid-induced ER stress markers, CHOP, Bip, ATF-6, XBP-1, ATF-4, and PERK. Palmitic Acid 30-43 activating transcription factor 6 Mus musculus 82-87 29468369-11 2018 In vitro, 15-HETE upregulated ER stress markers such as phosphorylated RNA-dependent protein kinase-like ER-regulated kinase (p-PERK), activating transcription factor 6 (ATF6) and protein disulfide isomerase (PDI) in HRECs. 15-Hete 10-17 activating transcription factor 6 Mus musculus 135-168 29468369-11 2018 In vitro, 15-HETE upregulated ER stress markers such as phosphorylated RNA-dependent protein kinase-like ER-regulated kinase (p-PERK), activating transcription factor 6 (ATF6) and protein disulfide isomerase (PDI) in HRECs. 15-Hete 10-17 activating transcription factor 6 Mus musculus 170-174 29626480-5 2018 TSPA restored the tunicamycin (TM)-stimulated insulin receptor (IR) desensitization through ATF6alpha activation, inhibited gluconeogenesis and efficiently improved glucose homeostasis on db/db mice. Tunicamycin 18-29 activating transcription factor 6 Mus musculus 92-101 29626480-5 2018 TSPA restored the tunicamycin (TM)-stimulated insulin receptor (IR) desensitization through ATF6alpha activation, inhibited gluconeogenesis and efficiently improved glucose homeostasis on db/db mice. Tunicamycin 31-33 activating transcription factor 6 Mus musculus 92-101 29626480-7 2018 Our current study has determined that ATF6alpha was a promising therapeutic target and also highlighted the potential of TSPA in the treatment of type 2 diabetes mellitus (T2DM). Thiotepa 121-125 activating transcription factor 6 Mus musculus 38-47 28833755-8 2018 Furthermore, tacrolimus inhibited glucose-regulated protein (GRP78), protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1 (IRE 1), and activating transcription factor 6 (ATF6) augmented by interleukin-1beta, thapsigargin, or both. Tacrolimus 13-23 activating transcription factor 6 Mus musculus 162-195 28833755-8 2018 Furthermore, tacrolimus inhibited glucose-regulated protein (GRP78), protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1 (IRE 1), and activating transcription factor 6 (ATF6) augmented by interleukin-1beta, thapsigargin, or both. Tacrolimus 13-23 activating transcription factor 6 Mus musculus 197-201 29581524-0 2018 Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Alcohols 19-26 activating transcription factor 6 Mus musculus 102-106 29523177-6 2018 The mechanism involves a notable rise in the levels of transcriptionally active ATF6 protein in the hippocampus after repaglinide administration. repaglinide 118-129 activating transcription factor 6 Mus musculus 80-84 29589392-6 2018 Pioglitazone remarkably reduced the expression of ATF6alpha, GRP78, and monocyte chemoattractant protein-1, prevented alpha-cell infiltration into the pancreatic islets, and upregulated glucose transporter 2 (Glut2) expression in beta-cells. Pioglitazone 0-12 activating transcription factor 6 Mus musculus 50-59 29272018-15 2017 In addition, it was also found that carvedilol could down-regulate the mRNA expression levels of iNOS, COX-2 and TGF-beta1, down-regulate the mRNA and protein expression levels of alpha-SMA and collagen-1, and negatively regulate the ATF4-CHOP, ATF6-CHOP and IRE1-pJNK signaling pathways. Carvedilol 36-46 activating transcription factor 6 Mus musculus 245-249 30537742-0 2018 Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism. Resveratrol 0-11 activating transcription factor 6 Mus musculus 77-81 30537742-5 2018 The effects of RSV on the expression levels of LD-associated genes (ATF6, Fsp27beta/CIDEC, CREBH, and PLIN1) were measured by qRT-PCR and western blot assays, followed by KD or overexpression of SIRT1 and ATF6 with small interfering RNAs or overexpressed plasmids, respectively. Resveratrol 15-18 activating transcription factor 6 Mus musculus 68-72 30537742-8 2018 RSV notably activated SIRT1 expression and decreased the expression levels of ATF6, Fsp27beta/CIDEC, CREBH, and PLIN1, which are associated with LD accumulation. Resveratrol 0-3 activating transcription factor 6 Mus musculus 78-82 30537742-10 2018 On the contrary, the benefits of RSV in hepatocytes were eliminated or aggravated when transfected with the overexpressed ATF6 or ATF6 siRNA, respectively. Resveratrol 33-36 activating transcription factor 6 Mus musculus 122-126 30537742-10 2018 On the contrary, the benefits of RSV in hepatocytes were eliminated or aggravated when transfected with the overexpressed ATF6 or ATF6 siRNA, respectively. Resveratrol 33-36 activating transcription factor 6 Mus musculus 130-134 30537742-11 2018 Furthermore, we found that RSV stimulated SIRT1 expression significantly, which was followed by increased deacetylation and inactivation of ATF6, resulting in a positive feedback loop for SIRT1 transcription associated with ATF6 binding to the SIRT1 promoter region. Resveratrol 27-30 activating transcription factor 6 Mus musculus 140-144 30537742-11 2018 Furthermore, we found that RSV stimulated SIRT1 expression significantly, which was followed by increased deacetylation and inactivation of ATF6, resulting in a positive feedback loop for SIRT1 transcription associated with ATF6 binding to the SIRT1 promoter region. Resveratrol 27-30 activating transcription factor 6 Mus musculus 224-228 30537742-12 2018 CONCLUSION: Taken together, these findings indicate that RSV supplementation improves hepatic steatosis by ameliorating the accumulation of LDs, and this might be partially mediated by a SIRT1/ATF6-dependent mechanism. Resveratrol 57-60 activating transcription factor 6 Mus musculus 193-197 29223538-12 2018 Transient transfection studies also showed that curcumin increased ATF6-Luc activity, while decreasing the activities of CREBH-Luc and SMILE-Luc. Curcumin 48-56 activating transcription factor 6 Mus musculus 67-71 29223538-14 2018 SIGNIFICANCE: Overall, these results demonstrate that curcumin-induced mild ER stress increases osteoblast differentiation via ATF6 expression in C3H10T1/2 cells. Curcumin 54-62 activating transcription factor 6 Mus musculus 127-131 29272018-16 2017 CONCLUSIONS: Carvedilol has a significant effect on alleviating the biliary cirrhosis in mice, and its relevant mechanism may be that carvedilol inhibits the endoplasmic reticulum stress through the negative regulation of ATF4-CHOP, ATF6-CHOP and IRE1-pJNK signaling pathways, which needs to be confirmed by further in vitro experiments. Carvedilol 13-23 activating transcription factor 6 Mus musculus 233-237 29272018-16 2017 CONCLUSIONS: Carvedilol has a significant effect on alleviating the biliary cirrhosis in mice, and its relevant mechanism may be that carvedilol inhibits the endoplasmic reticulum stress through the negative regulation of ATF4-CHOP, ATF6-CHOP and IRE1-pJNK signaling pathways, which needs to be confirmed by further in vitro experiments. Carvedilol 134-144 activating transcription factor 6 Mus musculus 233-237 28693924-1 2017 The Golgi-resident site-1 protease (S1P) is a key regulator of cholesterol homeostasis and ER stress responses by converting latent transcription factors sterol regulatory element binding proteins (SREPBs) and activating transcription factor 6 (ATF6), as well as viral glycoproteins to their active forms. Cholesterol 63-74 activating transcription factor 6 Mus musculus 210-243 28693924-1 2017 The Golgi-resident site-1 protease (S1P) is a key regulator of cholesterol homeostasis and ER stress responses by converting latent transcription factors sterol regulatory element binding proteins (SREPBs) and activating transcription factor 6 (ATF6), as well as viral glycoproteins to their active forms. Cholesterol 63-74 activating transcription factor 6 Mus musculus 245-249 28100484-0 2017 ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. Steroids 89-104 activating transcription factor 6 Mus musculus 0-4 28677092-11 2017 Chlorogenic acid could also significantly down-regulate the level of phosphorylation of PERK and cleaved ATF-6 in vivo study. Chlorogenic Acid 0-16 activating transcription factor 6 Mus musculus 105-110 28672279-0 2017 beta-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1alpha/ATF6 pathway. beta-elemene 0-12 activating transcription factor 6 Mus musculus 114-118 28672279-10 2017 Not only that, beta-elemene could up-regulate ERs-related proteins like PERK, IRE1alpha, ATF6, ATF4, CHOP and down-regulate the Bcl-2 expression. beta-elemene 15-27 activating transcription factor 6 Mus musculus 89-93 28672279-11 2017 More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. 4-phenylbutylamine 32-37 activating transcription factor 6 Mus musculus 71-75 28672279-11 2017 More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. 4-phenylbutylamine 32-37 activating transcription factor 6 Mus musculus 91-95 28672279-11 2017 More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. GSK2656157 115-125 activating transcription factor 6 Mus musculus 71-75 28672279-11 2017 More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. beta-elemene 243-255 activating transcription factor 6 Mus musculus 71-75 28672279-11 2017 More importantly, ERs inhibitor 4-PBA, IRE1alpha inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of beta-elemene. beta-elemene 243-255 activating transcription factor 6 Mus musculus 91-95 28672279-12 2017 Therefore, the present in vivo and in vitro study revealed that the anti-NSCLC effect of beta-elemene is closely related to the activation of ERs through PERK/IRE1alpha/ATF6 pathway, and this might be beneficial for clinical therapy of NSCLC. beta-elemene 89-101 activating transcription factor 6 Mus musculus 169-173 28671608-6 2017 Treatment with palmitate, which mimics cellular lipotoxicity, induced mesangial cell apoptosis via protein kinase RNA-like endoplasmic reticulum kinase (PERK) and ATF6-mediated endoplasmic reticulum (ER) stress signaling. Palmitates 15-24 activating transcription factor 6 Mus musculus 163-167 27932512-4 2017 METHODS AND RESULTS: Knockdown of ATF6 in cardiac myocytes subjected to I/R increased reactive oxygen species and necrotic cell death, both of which were mitigated by ATF6 overexpression. Reactive Oxygen Species 86-109 activating transcription factor 6 Mus musculus 34-38 27932512-8 2017 Many of the proteins encoded by the ATF6-induced oxidative stress genes identified here reside outside the ER, including catalase, which is known to decrease damaging reactive oxygen species in the heart. Reactive Oxygen Species 167-190 activating transcription factor 6 Mus musculus 36-40 28100484-3 2017 The aim of this study was to assess the role of ATF6 in mouse granulosa cells with respect to apoptosis, the cell cycle, and steroid hormone production, as well as several key genes related to follicular development, via RNA interference, immunohistochemical staining, real-time quantitative PCR, Western blotting, flow cytometry, terminal deoxynucleotidyltransferase-mediated deoxy-UTP nick end labeling (TUNEL) assay, and ELISA. Steroids 125-140 activating transcription factor 6 Mus musculus 48-52 28100484-9 2017 Interestingly, ATF6 knockdown obviously increased progesterone and estradiol production in mouse granulosa cells. Progesterone 50-62 activating transcription factor 6 Mus musculus 15-19 28100484-9 2017 Interestingly, ATF6 knockdown obviously increased progesterone and estradiol production in mouse granulosa cells. Estradiol 67-76 activating transcription factor 6 Mus musculus 15-19 28100484-13 2017 Collectively, these results imply that ATF6, as a key player in ER stress signaling, may regulate apoptosis, the cell cycle, steroid hormone synthesis, and other modulators related to folliculogenesis in mouse granulosa cells, which may indirectly be involved in the development, ovulation, and atresia of ovarian follicles by affecting the physiological function of granulosa cells. Steroids 125-140 activating transcription factor 6 Mus musculus 39-43 27907038-8 2016 Furthermore, equol treatment attenuated palmitate, t-BHP or thapsigargin-induced upregulation of ER stress markers, including p-PERK, p-eIF2alpha, GRP78, ATF6 and CHOP proteins expression. Equol 13-18 activating transcription factor 6 Mus musculus 154-158 27217380-6 2017 After the ATF6 branch was activated in ATF6-KI mice with tamoxifen, mice were subjected to transient middle cerebral artery occlusion. Tamoxifen 57-66 activating transcription factor 6 Mus musculus 10-14 27813192-9 2017 We found that GRP78, IRE1alpha, PERK and ATF6 gene expression and steatosis significantly reduced in naltrexone treated animals. Naltrexone 101-111 activating transcription factor 6 Mus musculus 41-45 26990902-5 2017 Triptolide increased protein levels of Fas, Fas-L, Bax, cytochrome c, caspase-9, Endo G, Apaf-1, PARP, caspase-3 but reduced levels of AIF, ATF6alpha, ATF6beta, and GRP78 in WEHI-3 cells. triptolide 0-10 activating transcription factor 6 Mus musculus 140-149 27907038-8 2016 Furthermore, equol treatment attenuated palmitate, t-BHP or thapsigargin-induced upregulation of ER stress markers, including p-PERK, p-eIF2alpha, GRP78, ATF6 and CHOP proteins expression. Thapsigargin 60-72 activating transcription factor 6 Mus musculus 154-158 27527870-10 2016 Ethanol-induced endoplasmic reticulum stress was demonstrated by a significant increase in ATF6, CHOP, and the phosphorylation of PERK and eiF-2alpha. Ethanol 0-7 activating transcription factor 6 Mus musculus 91-95 29268276-12 2017 When exploring the underlying mechanisms, we found melatonin could counteract ERS by decreasing the expression levels of the ERS markers GRP78, ATF6, pIRE1 and XBP1 in mouse testes and mouse SSCs (C18-4 cells). Melatonin 51-60 activating transcription factor 6 Mus musculus 144-148 27717400-7 2016 In addition, the expression of ATF6alpha was affected by progesterone (P4) and estrogen (E2) in ovariectomized mice. Progesterone 57-69 activating transcription factor 6 Mus musculus 31-40 27207533-0 2016 Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor alpha. Fatty Acids 23-33 activating transcription factor 6 Mus musculus 8-12 27323860-0 2016 Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1alpha and PERK pathways. Methamphetamine 0-15 activating transcription factor 6 Mus musculus 114-118 27207533-3 2016 Overexpression of dnATF6 or small interfering RNA-mediated knockdown of ATF6 decreases the transcriptional activity of peroxisome proliferator-activated receptor alpha (PPARalpha)/retinoid X receptor complex, and inhibits oxygen consumption rates in hepatocytes, possibly through inhibition of the binding of PPARalpha to the promoter of its target gene. Oxygen 222-228 activating transcription factor 6 Mus musculus 20-24 27207533-5 2016 Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin-resistant mice. Fatty Acids 80-90 activating transcription factor 6 Mus musculus 58-62 27207533-6 2016 These data delineate the mechanism by which ATF6 controls the activity of PPARalpha and hepatic mitochondria fatty acid oxidation. Fatty Acids 109-119 activating transcription factor 6 Mus musculus 44-48 25409916-6 2016 Moreover, Cd and Cr exposures also elevated the transcription of the oxidative- and endoplasmic reticulum (ER)-stress related genes including Cat, Gpx, heme oxygenase 1 (Ho-1), regulated protein 78 (Grp78), activating transcription factor 6 (Atf6) and proaoptotic CCAAT/-enhancer-binding protein homologous protein (Chop) in a dose dependent manner in the liver. Cadmium 10-12 activating transcription factor 6 Mus musculus 207-240 25409916-6 2016 Moreover, Cd and Cr exposures also elevated the transcription of the oxidative- and endoplasmic reticulum (ER)-stress related genes including Cat, Gpx, heme oxygenase 1 (Ho-1), regulated protein 78 (Grp78), activating transcription factor 6 (Atf6) and proaoptotic CCAAT/-enhancer-binding protein homologous protein (Chop) in a dose dependent manner in the liver. Cadmium 10-12 activating transcription factor 6 Mus musculus 242-246 25409916-6 2016 Moreover, Cd and Cr exposures also elevated the transcription of the oxidative- and endoplasmic reticulum (ER)-stress related genes including Cat, Gpx, heme oxygenase 1 (Ho-1), regulated protein 78 (Grp78), activating transcription factor 6 (Atf6) and proaoptotic CCAAT/-enhancer-binding protein homologous protein (Chop) in a dose dependent manner in the liver. Chromium 17-19 activating transcription factor 6 Mus musculus 207-240 25409916-6 2016 Moreover, Cd and Cr exposures also elevated the transcription of the oxidative- and endoplasmic reticulum (ER)-stress related genes including Cat, Gpx, heme oxygenase 1 (Ho-1), regulated protein 78 (Grp78), activating transcription factor 6 (Atf6) and proaoptotic CCAAT/-enhancer-binding protein homologous protein (Chop) in a dose dependent manner in the liver. Chromium 17-19 activating transcription factor 6 Mus musculus 242-246 26999661-6 2016 These beneficial effects of UDCA or 4-PBA on DN were associated with the inhibition of ER stress, as evidenced by the decreased expression of BiP, phospho-IRE1alpha, phospho-eIF2alpha, CHOP, ATF-6 and spliced X-box binding protein-1 in vitro and in vivo. 4-phenylbutyric acid 36-41 activating transcription factor 6 Mus musculus 191-196 26838784-5 2016 Doxorubicin activated an ER transmembrane stress sensor, activating transcription factor 6, in cultured cardiomyocytes and mouse hearts. Doxorubicin 0-11 activating transcription factor 6 Mus musculus 57-90 26838784-6 2016 However, doxorubicin suppressed the expression of genes downstream of activating transcription factor 6, including X-box binding protein 1. Doxorubicin 9-20 activating transcription factor 6 Mus musculus 70-103 26640164-12 2016 The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice. bicyclol 124-132 activating transcription factor 6 Mus musculus 90-94 26752648-6 2016 Repaglinide blocked this interaction and enhanced ATF6 processing and nuclear accumulation of transcriptionally active ATF6, improving prosurvival UPR function in striatal neurons. repaglinide 0-11 activating transcription factor 6 Mus musculus 50-54 26752648-6 2016 Repaglinide blocked this interaction and enhanced ATF6 processing and nuclear accumulation of transcriptionally active ATF6, improving prosurvival UPR function in striatal neurons. repaglinide 0-11 activating transcription factor 6 Mus musculus 119-123 26708632-5 2016 On the other hand, TG-induced upregulation of BiP and CHOP as well as most ERAD-related genes, but not spliced XBP1 or ATF4, was attenuated in ATF6alpha(-/-) mice compared with WT mice. Thapsigargin 19-21 activating transcription factor 6 Mus musculus 143-152 26740650-5 2016 We evoked mild endoplasmic reticulum (ER) stress with tunicamycin (Tu), producing modest increases in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein. Tunicamycin 54-65 activating transcription factor 6 Mus musculus 123-127 26740650-5 2016 We evoked mild endoplasmic reticulum (ER) stress with tunicamycin (Tu), producing modest increases in the level of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein. Tunicamycin 67-69 activating transcription factor 6 Mus musculus 123-127 26640164-12 2016 The gene expressions of ER stress-related markers, including CHOP, GRP78, IRE-1alpha, and ATF6, which were downregulated by bicyclol pretreatment in tetracycline-injected mice. Tetracycline 149-161 activating transcription factor 6 Mus musculus 90-94 26683792-15 2016 Subsequently, we performed chromatin immunoprecipitation assay and demonstrated that treatment of beta-TC-6 cells with 25mmol/L glucose decreases gradually the binding enrichment of ATF6 and XBP1 in ERp46 gene promoter. beta-tc 98-105 activating transcription factor 6 Mus musculus 182-186 26683792-15 2016 Subsequently, we performed chromatin immunoprecipitation assay and demonstrated that treatment of beta-TC-6 cells with 25mmol/L glucose decreases gradually the binding enrichment of ATF6 and XBP1 in ERp46 gene promoter. Glucose 128-135 activating transcription factor 6 Mus musculus 182-186 26724566-0 2016 Deletion of Atf6alpha enhances kainate-induced neuronal death in mice. Kainic Acid 31-38 activating transcription factor 6 Mus musculus 12-21 26788255-9 2016 Nuclear translocation of ATF6 was observed in HC hepatocytes treated with ethanol, results that indicate that lipids overload and ethanol treatment favor ER stress. Ethanol 74-81 activating transcription factor 6 Mus musculus 25-29 26788255-9 2016 Nuclear translocation of ATF6 was observed in HC hepatocytes treated with ethanol, results that indicate that lipids overload and ethanol treatment favor ER stress. Ethanol 130-137 activating transcription factor 6 Mus musculus 25-29 27504150-6 2016 Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation). Quercetin 13-22 activating transcription factor 6 Mus musculus 162-195 26724566-7 2016 Furthermore, an injection of dantrolene, an inhibitor of ryanodine receptor, partially rescued these effects in Atf6alpha(-/-) mice after KA injection. Dantrolene 29-39 activating transcription factor 6 Mus musculus 112-121 27504150-6 2016 Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation). Quercetin 13-22 activating transcription factor 6 Mus musculus 197-201 27504150-8 2016 SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-kappaB inhibitor) enhanced the quercetin-induced protection against Tg stimulation. Quercetin 105-114 activating transcription factor 6 Mus musculus 33-37 26093960-4 2015 MC-LR treatment at 10 or 20 mug/kg/d changed mRNA and protein expression of ER stress signaling molecules, including upregulation of mRNA and protein expression of activating transcription factor 6 (ATF6), pancreatic ER eukaryotic translation initiation factor 2alpha (eIF-2alpha) kinase (PERK), and eIF-2alpha. cyanoginosin LR 0-5 activating transcription factor 6 Mus musculus 164-197 27504150-8 2016 SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-kappaB inhibitor) enhanced the quercetin-induced protection against Tg stimulation. Thapsigargin 142-144 activating transcription factor 6 Mus musculus 33-37 26599511-7 2015 Kaempferol inhibited tunicamycin-induced ER stress of airway epithelial cells through disturbing the activation of the ER transmembrane sensor ATF6 and IRE1alpha. kaempferol 0-10 activating transcription factor 6 Mus musculus 143-147 26599511-7 2015 Kaempferol inhibited tunicamycin-induced ER stress of airway epithelial cells through disturbing the activation of the ER transmembrane sensor ATF6 and IRE1alpha. Tunicamycin 21-32 activating transcription factor 6 Mus musculus 143-147 26093960-4 2015 MC-LR treatment at 10 or 20 mug/kg/d changed mRNA and protein expression of ER stress signaling molecules, including upregulation of mRNA and protein expression of activating transcription factor 6 (ATF6), pancreatic ER eukaryotic translation initiation factor 2alpha (eIF-2alpha) kinase (PERK), and eIF-2alpha. cyanoginosin LR 0-5 activating transcription factor 6 Mus musculus 199-203 28377952-0 2015 Mineral trioxide aggregate induces osteoblastogenesis via Atf6. mineral trioxide 0-16 activating transcription factor 6 Mus musculus 58-62 28377952-9 2015 Furthermore, knockdown of Atf6 gene expression by introduction of Tet-on Atf6 shRNA expression vector abrogated MTA-induced mineralization. tetramethylenedisulfotetramine 66-69 activating transcription factor 6 Mus musculus 26-30 28377952-9 2015 Furthermore, knockdown of Atf6 gene expression by introduction of Tet-on Atf6 shRNA expression vector abrogated MTA-induced mineralization. tetramethylenedisulfotetramine 66-69 activating transcription factor 6 Mus musculus 73-77 25620058-6 2015 Tunicamycin caused UPR in the cerebral cortex, hippocampus and cerebellum of mice of PD4 and PD12, which was evident by the upregulation of ATF6, XBP1s, p-eIF2alpha, GRP78, GRP94 and MANF, but failed to induce UPR in the brain of PD25 mice. Tunicamycin 0-11 activating transcription factor 6 Mus musculus 140-144 24607296-6 2014 Interestingly, rapamycin pretreatment significantly suppressed light-induced ER stress and all three major branches of the unfolded protein response (UPR), including the RNA-dependent protein kinase-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6) pathways both at the protein and mRNA levels. Sirolimus 15-24 activating transcription factor 6 Mus musculus 262-295 25187414-6 2014 Our results showed that Hcy triggered ER stress characterized by an increased contents of glucose-regulated protein 78 (GRP78), protein kinase RNA-like ER kinase (PERK), activating transcription factor (ATF) 6 and X-box binding protein-1 (XBP-1). Homocysteine 24-27 activating transcription factor 6 Mus musculus 170-209 24818755-9 2014 Further analysis showed that melatonin markedly attenuated BLM-induced GRP78 up-regulation and elevation of the cleaved ATF6 in the lungs. Melatonin 29-38 activating transcription factor 6 Mus musculus 120-124 25135476-10 2014 The terminal enzyme in this pathway, p38 MAPK, phosphorylates a critical threonine residue in ATF6 upstream of its DNA binding domain. Threonine 73-82 activating transcription factor 6 Mus musculus 94-98 24917047-9 2014 Moreover, the EVOO-enriched diet improved the muscle status as shown by expression of myogenic factors (Myod1 and Myog) and autophagy markers (LC3 and Beclin1), as well as diminished endoplasmic reticulum (ER) stress through decreasing Atf6 and Grp78. evoo 14-18 activating transcription factor 6 Mus musculus 236-240 24607296-6 2014 Interestingly, rapamycin pretreatment significantly suppressed light-induced ER stress and all three major branches of the unfolded protein response (UPR), including the RNA-dependent protein kinase-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6) pathways both at the protein and mRNA levels. Sirolimus 15-24 activating transcription factor 6 Mus musculus 297-301 24364984-7 2013 SiRNA-mediated knockdown of ATF6alpha and ERp57 during HDM administration in mice resulted in a decrease in components of HDM-induced ER stress, disulfide mediated oligomerization of Bak, and activation of caspase-3. Disulfides 145-154 activating transcription factor 6 Mus musculus 28-37 23907580-5 2013 We also found that TE down-regulated the expression of GRP78/Bip and PDI proteins and inhibited activation of PERK, eIF2alpha, ATF6alpha, sXBP1 and JNK-p38 MAPK as well as activation of CHOP, caspase-12 and caspase-3. Tellurium 19-21 activating transcription factor 6 Mus musculus 127-136 23892647-5 2014 Moreover, arsenic activated UPR, leading to phosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), induction of ATF4, and processing of ATF6. Arsenic 10-17 activating transcription factor 6 Mus musculus 170-174 23892647-7 2014 The activation of eIF2alpha, ATF4 and ATF6 and expression of GRP78 and CHOP are repressed by both LA and tiron, indicating arsenic-induced UPR is mediated through ROS-dependent and ROS-independent pathways. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 105-110 activating transcription factor 6 Mus musculus 38-42 23892647-7 2014 The activation of eIF2alpha, ATF4 and ATF6 and expression of GRP78 and CHOP are repressed by both LA and tiron, indicating arsenic-induced UPR is mediated through ROS-dependent and ROS-independent pathways. Arsenic 123-130 activating transcription factor 6 Mus musculus 38-42 23877657-10 2013 Inhibition of protein degradation by BTZ led to the induction of UPR; induction of XBP1 splicing, ATF6 proteolysis and nuclear ATF4 as well as BiP and CHOP expressions were evident. Bortezomib 37-40 activating transcription factor 6 Mus musculus 98-102 23864333-4 2013 Treatment with thapsigargin (Tg) induced MANF mRNA generation in parallel with the elevation of ATF6alpha, sXBP and Luman mRNA levels in Neuro2a cells. Thapsigargin 15-27 activating transcription factor 6 Mus musculus 96-105 23864333-4 2013 Treatment with thapsigargin (Tg) induced MANF mRNA generation in parallel with the elevation of ATF6alpha, sXBP and Luman mRNA levels in Neuro2a cells. Thapsigargin 29-31 activating transcription factor 6 Mus musculus 96-105 23037953-0 2013 Activating transcription factor 6 mediates oxidized LDL-induced cholesterol accumulation and apoptosis in macrophages by up-regulating CHOP expression. Cholesterol 64-75 activating transcription factor 6 Mus musculus 0-33 23618865-9 2013 These findings suggest that NE-100 suppresses ER stress-induced cell death via CHOP expression by the upregulation of GRP78 through ATF6 pathway, independent sigma-1 receptor antagonist effect. N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride 28-34 activating transcription factor 6 Mus musculus 132-136 23519122-5 2013 Presently, the impaired cellular availability of vitamin B12 in TO cells activated irreversible ER stress pathways, with increased P-eIF-2alpha, P-PERK, P-IRE1alpha, ATF6, ATF4, decreased chaperon proteins and increased pro-apoptotic markers, CHOP and cleaved caspase 3, through reduced SIRT1 expression and consequently greater acetylation of heat-shock factor protein 1 (HSF1). Vitamin B 12 49-60 activating transcription factor 6 Mus musculus 166-170 21793155-7 2013 Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells. Curcumin 15-23 activating transcription factor 6 Mus musculus 234-267 21793155-7 2013 Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells. Curcumin 15-23 activating transcription factor 6 Mus musculus 269-274 21793155-7 2013 Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells. Curcumin 100-108 activating transcription factor 6 Mus musculus 234-267 21793155-7 2013 Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells. Curcumin 100-108 activating transcription factor 6 Mus musculus 269-274 23336977-5 2013 RESULTS: P58(IPK-/-) and Atf6alpha(-/-) mice developed more severe colitis following administration of DSS than wild-type mice. Dextran Sulfate 103-106 activating transcription factor 6 Mus musculus 25-34 23336977-8 2013 Oral administration of either PBA or TUDCA reduced features of DSS-induced acute and chronic colitis in wild-type mice, the colitis that develops in Il10(-/-) mice, and DSS-induced colitis in P58(IPK-/-) and Atf6alpha(-/-) mice. ursodoxicoltaurine 37-42 activating transcription factor 6 Mus musculus 208-217 23395094-3 2013 Exposure of endothelial cells to VEGF, high glucose, or H2O2 up-regulated the X-box binding protein-1/inositol-requiring protein-1 (IRE1) alpha and activating transcription factor 6 (ATF6) arms of the UPR compared with untreated cells. Glucose 44-51 activating transcription factor 6 Mus musculus 148-181 23395094-3 2013 Exposure of endothelial cells to VEGF, high glucose, or H2O2 up-regulated the X-box binding protein-1/inositol-requiring protein-1 (IRE1) alpha and activating transcription factor 6 (ATF6) arms of the UPR compared with untreated cells. Glucose 44-51 activating transcription factor 6 Mus musculus 183-187 23395094-3 2013 Exposure of endothelial cells to VEGF, high glucose, or H2O2 up-regulated the X-box binding protein-1/inositol-requiring protein-1 (IRE1) alpha and activating transcription factor 6 (ATF6) arms of the UPR compared with untreated cells. Hydrogen Peroxide 56-60 activating transcription factor 6 Mus musculus 148-181 23395094-3 2013 Exposure of endothelial cells to VEGF, high glucose, or H2O2 up-regulated the X-box binding protein-1/inositol-requiring protein-1 (IRE1) alpha and activating transcription factor 6 (ATF6) arms of the UPR compared with untreated cells. Hydrogen Peroxide 56-60 activating transcription factor 6 Mus musculus 183-187 23395094-7 2013 Blockade of IRE1alpha or ATF6 in the oxygen-induced retinopathy or choroidal neovascularization mouse models caused an approximately 35% reduction in angiogenesis. Oxygen 37-43 activating transcription factor 6 Mus musculus 25-29 23037953-1 2013 AIM: This study was to explore whether activating transcription factor 6 (ATF6), an important sensor to endoplasmic reticulum (ER) stress, would mediate oxidized low-density lipoprotein (ox-LDL)- induced cholesterol accumulation and apoptosis in cultured macrophages and the underlying molecular mechanisms. Cholesterol 204-215 activating transcription factor 6 Mus musculus 39-72 23037953-1 2013 AIM: This study was to explore whether activating transcription factor 6 (ATF6), an important sensor to endoplasmic reticulum (ER) stress, would mediate oxidized low-density lipoprotein (ox-LDL)- induced cholesterol accumulation and apoptosis in cultured macrophages and the underlying molecular mechanisms. Cholesterol 204-215 activating transcription factor 6 Mus musculus 74-78 23037953-6 2013 ATF6 siRNA was transfected to RAW264.7 cells by lipofectamin. lipofectamin 48-60 activating transcription factor 6 Mus musculus 0-4 23037953-10 2013 The role of the ATF6-mediated ER stress pathway was further confirmed through the siRNA-mediated knockdown of ATF6, which attenuated ox-LDL-induced upregulation of CHOP, cholesterol accumulation and apoptosis in macrophages. Cholesterol 170-181 activating transcription factor 6 Mus musculus 16-20 23037953-10 2013 The role of the ATF6-mediated ER stress pathway was further confirmed through the siRNA-mediated knockdown of ATF6, which attenuated ox-LDL-induced upregulation of CHOP, cholesterol accumulation and apoptosis in macrophages. Cholesterol 170-181 activating transcription factor 6 Mus musculus 110-114 23037953-12 2013 CONCLUSION: These results demonstrate that ER stress-related proteins, particularly ATF6 and its downstream molecule CHOP, are involved in ox-LDL-induced cholesterol accumulation and apoptosis in macrophages. Cholesterol 154-165 activating transcription factor 6 Mus musculus 84-88 22390177-8 2012 Treatment with the ER stressor thapsigargin enhanced phosphorylation of eIF2alpha and activated proteolysis of ATF6alpha and splicing of XBP1 in NSC34 and motor neurons in a time-dependent manner. Thapsigargin 31-43 activating transcription factor 6 Mus musculus 111-120 22926926-4 2012 Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha. apicidin 0-8 activating transcription factor 6 Mus musculus 166-204 23000915-7 2012 In addition, piperine downregulated the expression of genes involved in ER stress, including GRP78, activating transcription factor 6, and eukaryotic translation initiation factor 2alpha, and upregulated GLUT2 translocation from the cytosol to the plasma membrane in the livers of PSD mice. piperine 13-21 activating transcription factor 6 Mus musculus 100-133 22386934-5 2012 Atf6alpha(-/-) DO mice were less glucose tolerant with blunted insulin secretion compared to littermates on a high-fat diet. Glucose 33-40 activating transcription factor 6 Mus musculus 0-9 22386934-9 2012 However, Atf6alpha(-/-) DO mice exhibited higher insulin sensitivity with lower serum triglyceride levels. Triglycerides 86-98 activating transcription factor 6 Mus musculus 9-18 22609432-5 2012 In this study, we showed that, in the mouse heart, and in cultured cardiac myocytes, ATF6 induced the protein disulfide isomerase associated 6 (PDIA6) gene, which encodes an ER enzyme that catalyzes protein disulfide bond formation. Disulfides 110-119 activating transcription factor 6 Mus musculus 85-89 22379121-7 2012 Nicotine also attenuated endogenously expressed ATF6 translocation and phosphorylation of eukaryotic initiation factor 2alpha in mouse cortical neurons transfected with alpha4beta2 nAChRs. Nicotine 0-8 activating transcription factor 6 Mus musculus 48-52 22134971-3 2012 Although taxol treatment induced activating transcription factor 6 (ATF6) cleavage indicative of endoplasmic reticulum (ER) stress, silencing ATF6 by shATF6 did not prevent taxol-induced both cytotoxcity and cytoplasmic vacuolization, suggesting that taxol-induced cytoplasmic vacuolization and cell death were not due to ER stress. Paclitaxel 9-14 activating transcription factor 6 Mus musculus 68-72 22134971-3 2012 Although taxol treatment induced activating transcription factor 6 (ATF6) cleavage indicative of endoplasmic reticulum (ER) stress, silencing ATF6 by shATF6 did not prevent taxol-induced both cytotoxcity and cytoplasmic vacuolization, suggesting that taxol-induced cytoplasmic vacuolization and cell death were not due to ER stress. shatf6 150-156 activating transcription factor 6 Mus musculus 142-146 18650380-6 2008 Down-regulation of ATF6alpha or Rheb reverted dormant tumor cell resistance to rapamycin and induced pronounced killing only of dormant cancer cells in vivo. Sirolimus 79-88 activating transcription factor 6 Mus musculus 19-28 23112876-3 2012 Enhanced activation of the UPR branches, including ATF6alpha and PERK/eIF2alpha/ATF4, was observed after MPTP/P injections into mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 105-109 activating transcription factor 6 Mus musculus 51-60 23112876-4 2012 Deletion of the ATF6alpha gene accelerated neuronal degeneration and ubiquitin accumulation relatively early in the MPTP/P injection course. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 116-120 activating transcription factor 6 Mus musculus 16-25 21131360-4 2011 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a dopaminergic neurotoxin known to produce oxidative stress, activated ATF6alpha and increased ER chaperones and ER-associated degradation (ERAD) component in dopaminergic neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0-44 activating transcription factor 6 Mus musculus 124-133 21131360-4 2011 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a dopaminergic neurotoxin known to produce oxidative stress, activated ATF6alpha and increased ER chaperones and ER-associated degradation (ERAD) component in dopaminergic neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 46-50 activating transcription factor 6 Mus musculus 124-133 21131360-5 2011 Importantly, MPTP induced formation of ubiquitin- immunopositive inclusions and loss of dopaminergic neurons more prominently in mice deficient in ATF6alpha than in wild-type mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 13-17 activating transcription factor 6 Mus musculus 147-156 21131360-6 2011 Cultured cell experiments revealed that 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress not only promoted phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) but also enhanced interaction between phosphorylated p38MAPK and ATF6alpha, leading to increment in transcriptional activator activity of ATF6alpha. 1-Methyl-4-phenylpyridinium 40-67 activating transcription factor 6 Mus musculus 251-260 21131360-6 2011 Cultured cell experiments revealed that 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress not only promoted phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) but also enhanced interaction between phosphorylated p38MAPK and ATF6alpha, leading to increment in transcriptional activator activity of ATF6alpha. 1-Methyl-4-phenylpyridinium 40-67 activating transcription factor 6 Mus musculus 324-333 21131360-6 2011 Cultured cell experiments revealed that 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress not only promoted phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) but also enhanced interaction between phosphorylated p38MAPK and ATF6alpha, leading to increment in transcriptional activator activity of ATF6alpha. mangion-purified polysaccharide (Candida albicans) 69-75 activating transcription factor 6 Mus musculus 251-260 21131360-6 2011 Cultured cell experiments revealed that 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress not only promoted phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) but also enhanced interaction between phosphorylated p38MAPK and ATF6alpha, leading to increment in transcriptional activator activity of ATF6alpha. mangion-purified polysaccharide (Candida albicans) 69-75 activating transcription factor 6 Mus musculus 324-333 21131360-7 2011 Thus, our results revealed a link between oxidative stress and ER stress by showing the importance of ATF6alpha in the protection of the dopaminergic neurons from MPTP that occurs through oxidative stress-induced activation of ATF6alpha and p38MAPK-mediated enhancement of ATF6alpha transcriptional activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 163-167 activating transcription factor 6 Mus musculus 102-111 21131360-7 2011 Thus, our results revealed a link between oxidative stress and ER stress by showing the importance of ATF6alpha in the protection of the dopaminergic neurons from MPTP that occurs through oxidative stress-induced activation of ATF6alpha and p38MAPK-mediated enhancement of ATF6alpha transcriptional activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 163-167 activating transcription factor 6 Mus musculus 227-236 21131360-7 2011 Thus, our results revealed a link between oxidative stress and ER stress by showing the importance of ATF6alpha in the protection of the dopaminergic neurons from MPTP that occurs through oxidative stress-induced activation of ATF6alpha and p38MAPK-mediated enhancement of ATF6alpha transcriptional activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 163-167 activating transcription factor 6 Mus musculus 227-236 20857693-5 2010 The induction of BiP mRNA by BIX was mediated by activation of ER stress response elements (ERSEs) upstream of the BiP gene, through the ATF6 pathway. 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate 29-32 activating transcription factor 6 Mus musculus 137-141 20380836-5 2010 Treatment of mice with 4-(2-aminoethyl) benzenesulfonyl fluoride, an inhibitor of ATF6, further reduced cardiac function and increased the mortality rate at 14days after MI. 4-(2-aminoethyl)benzenesulfonylfluoride 23-64 activating transcription factor 6 Mus musculus 82-86 19336499-8 2009 GRP78 is critical to the regulation of the two transcription factors, X-box binding protein 1 (XBP1) and activating transcription factor 6 (ATF6), which bind to cAMP-response element (CRE) and drive expression of CRE-dependent genes such as IL-6. Cyclic AMP 161-165 activating transcription factor 6 Mus musculus 105-138 19336499-8 2009 GRP78 is critical to the regulation of the two transcription factors, X-box binding protein 1 (XBP1) and activating transcription factor 6 (ATF6), which bind to cAMP-response element (CRE) and drive expression of CRE-dependent genes such as IL-6. Cyclic AMP 161-165 activating transcription factor 6 Mus musculus 140-144 19336499-9 2009 DON exposure was found to increase IRE1alpha protein, its modified products spliced XBP1 mRNA and XBP1 protein as well as ATF6. deoxynivalenol 0-3 activating transcription factor 6 Mus musculus 122-126 19336499-10 2009 Knockdown of ATF6 but not XBP1 partially inhibited DON-induced IL-6 expression in the macrophages. deoxynivalenol 51-54 activating transcription factor 6 Mus musculus 13-17 21976666-6 2011 Activation of the activating transcription factor 6 (ATF6) branch of the UPR by expression of spliced ATF6(1-373) decreased intracellular accumulation of ATZ and the formation of globular inclusions by a pathway that required HRD1 and the proteasome. Atazanavir Sulfate 154-157 activating transcription factor 6 Mus musculus 18-51 21976666-6 2011 Activation of the activating transcription factor 6 (ATF6) branch of the UPR by expression of spliced ATF6(1-373) decreased intracellular accumulation of ATZ and the formation of globular inclusions by a pathway that required HRD1 and the proteasome. Atazanavir Sulfate 154-157 activating transcription factor 6 Mus musculus 53-57 21976666-6 2011 Activation of the activating transcription factor 6 (ATF6) branch of the UPR by expression of spliced ATF6(1-373) decreased intracellular accumulation of ATZ and the formation of globular inclusions by a pathway that required HRD1 and the proteasome. Atazanavir Sulfate 154-157 activating transcription factor 6 Mus musculus 102-106 21976666-9 2011 It was concluded that activation of the ATF6 pathway of the UPR limits ATZ-dependent cell toxicity by selectively promoting ER-associated degradation of ATZ and is thereby a potential target to prevent hepatocyte loss in addition to autophagy-enhancing drugs. Atazanavir Sulfate 71-74 activating transcription factor 6 Mus musculus 40-44 21976666-9 2011 It was concluded that activation of the ATF6 pathway of the UPR limits ATZ-dependent cell toxicity by selectively promoting ER-associated degradation of ATZ and is thereby a potential target to prevent hepatocyte loss in addition to autophagy-enhancing drugs. Atazanavir Sulfate 153-156 activating transcription factor 6 Mus musculus 40-44 21911445-4 2011 In this study, we showed that subchronic arsenic exposure to SKH-1 mice induced unfolded protein response (UPR) signaling regulated by proteins, inositol-requiring enzyme-1 (IRE1), PKR-like endoplasmic reticulum kinase (PERK) and activating transcription factor 6 (ATF6). Arsenic 41-48 activating transcription factor 6 Mus musculus 230-263 21911445-4 2011 In this study, we showed that subchronic arsenic exposure to SKH-1 mice induced unfolded protein response (UPR) signaling regulated by proteins, inositol-requiring enzyme-1 (IRE1), PKR-like endoplasmic reticulum kinase (PERK) and activating transcription factor 6 (ATF6). Arsenic 41-48 activating transcription factor 6 Mus musculus 265-269 21599712-9 2011 RESULTS: Ethanol exposure significantly increased the expression of ERSIPs and activated signaling pathways associated with ER stress; these include ATF6, CHOP/GADD153, GRP78, and mesencephalic astrocyte-derived neurotrophic factor as well as the phosphorylation of IRE1alpha, eIF2alpha, PERK, and PKR. Ethanol 9-16 activating transcription factor 6 Mus musculus 149-153 20811050-9 2011 The ER stress proteins PERK, ATF4, ATF6, IRE1alpha, and CHOP were upregulated in RGC-5 cells during oxidative stress, but decreased in the presence of (+)-pentazocine. Pentazocine 151-166 activating transcription factor 6 Mus musculus 35-39 20848490-8 2010 The Chol+/CA diet lowered the expression of the unfolded protein response genes ATF6, CHOP, unspliced Xbp(U) , and Grp78/Bip, in WT and DKO mice compared with mice on the Chol- diet. chol+ 4-9 activating transcription factor 6 Mus musculus 80-84 20848490-8 2010 The Chol+/CA diet lowered the expression of the unfolded protein response genes ATF6, CHOP, unspliced Xbp(U) , and Grp78/Bip, in WT and DKO mice compared with mice on the Chol- diet. chol 4-8 activating transcription factor 6 Mus musculus 80-84 20631254-4 2010 In this report, we burdened mice with intraperitoneal injection of the ER stress-inducing reagent tunicamycin and found that wild-type mice were able to recover from the insult, whereas ATF6alpha-knockout mice exhibited liver dysfunction and steatosis. Tunicamycin 98-109 activating transcription factor 6 Mus musculus 186-195 20631254-5 2010 Thus, ATF6alpha-knockout mice accumulated neutral lipids in the liver such as triacylglycerol and cholesterol, which was ascribable to blockage of beta-oxidation of fatty acids caused by decreased mRNA levels of the enzymes involved in the process, suppression of very-low-density lipoprotein formation due to destabilized apolipoprotein B-100, and stimulation of lipid droplet formation resulting from transcriptional induction of adipose differentiation-related protein. Triglycerides 78-93 activating transcription factor 6 Mus musculus 6-15 20631254-5 2010 Thus, ATF6alpha-knockout mice accumulated neutral lipids in the liver such as triacylglycerol and cholesterol, which was ascribable to blockage of beta-oxidation of fatty acids caused by decreased mRNA levels of the enzymes involved in the process, suppression of very-low-density lipoprotein formation due to destabilized apolipoprotein B-100, and stimulation of lipid droplet formation resulting from transcriptional induction of adipose differentiation-related protein. Cholesterol 98-109 activating transcription factor 6 Mus musculus 6-15 20631254-5 2010 Thus, ATF6alpha-knockout mice accumulated neutral lipids in the liver such as triacylglycerol and cholesterol, which was ascribable to blockage of beta-oxidation of fatty acids caused by decreased mRNA levels of the enzymes involved in the process, suppression of very-low-density lipoprotein formation due to destabilized apolipoprotein B-100, and stimulation of lipid droplet formation resulting from transcriptional induction of adipose differentiation-related protein. Fatty Acids 165-176 activating transcription factor 6 Mus musculus 6-15 20493918-5 2010 Apigenin also reduced the TG- and BFA-induced expression of ER stress-associated proteins, including C/EBP homologous protein (CHOP), glucose-regulated protein (GRP) 78 and GRP94, the cleavage of activating transcription factor 6alpha, the phosphorylation of eukaryotic initiation factor 2alpha and inositol-requiring enzyme 1alpha, and the activation of mitogen-activated protein kinases, such as p38, c-Jun NH(2)-terminal kinase, and extracellular-regulated kinase. Brefeldin A 34-37 activating transcription factor 6 Mus musculus 196-234 20022930-10 2010 Finally, we found that expression of ATF6 decreased fasting-induced PEPCK, G6Pase mRNA expression, and blood glucose levels in mice. Glucose 109-116 activating transcription factor 6 Mus musculus 37-41 17207453-2 2007 Sublethal dose of AAP resulted in a decrease in microsomal total glutathione and in the reduced-to-total glutathione ratio; redox state of thiols of ER resident oxidoreductases ERp72, PDI was shifted towards the oxidized form; ER stress-responsive transcription factor ATF6 was activated. Acetaminophen 18-21 activating transcription factor 6 Mus musculus 269-273 18336657-6 2008 The rapidity and magnitude of homocysteine-induced activation of each of the main ER resident transmembrane sensors including inositol requiring enzyme 1 (IRE-l alpha), activating transcription factor 6 (ATF-6) and RNA-activated protein kinase (PKR)-like ER kinase (PERK) appear different in different experimental models. Homocysteine 30-42 activating transcription factor 6 Mus musculus 169-202 18336657-6 2008 The rapidity and magnitude of homocysteine-induced activation of each of the main ER resident transmembrane sensors including inositol requiring enzyme 1 (IRE-l alpha), activating transcription factor 6 (ATF-6) and RNA-activated protein kinase (PKR)-like ER kinase (PERK) appear different in different experimental models. Homocysteine 30-42 activating transcription factor 6 Mus musculus 204-209 18049481-5 2008 The induction of BiP mRNA by BIX was mediated by activation of ER stress response elements upstream of the BiP gene, through the ATF6 (activating transcription factor 6) pathway. 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate 29-32 activating transcription factor 6 Mus musculus 129-133 18049481-5 2008 The induction of BiP mRNA by BIX was mediated by activation of ER stress response elements upstream of the BiP gene, through the ATF6 (activating transcription factor 6) pathway. 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate 29-32 activating transcription factor 6 Mus musculus 135-168