PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33934370-6	2021	Genetic deletion of Foxp2 in mice using the endothelial-specific Tie2-Cre or the tamoxifen-inducible LEC-specific Prox1-CreERT2 line resulted in enlarged collecting vessels and defective valves characterized by loss of NFATc1 activity.	Tamoxifen	81-90	prospero homeobox 1	Mus musculus	114-119
33315382-8	2021	Furthermore, brains from QTC-4-MeOBnE-treated mice had a significant increase in adult neurogenesis and remyelination through Prox1/NeuroD1 and Wnt/beta-catenin pathways.	qtc-4-meobne	25-37	prospero homeobox 1	Mus musculus	126-131
33987369-13	2021	MiR-140-5p negatively regulated downstream target Prox1 and activated the ERK/MAPK signaling pathway.	mir-140-5p	0-10	prospero homeobox 1	Mus musculus	50-55
33247761-9	2021	In accordance, Prox1 represses Ca2+ entry upon KCl-mediated depolarization and reduces CREB phosphorylation.	Potassium Chloride	47-50	prospero homeobox 1	Mus musculus	15-20
32958852-4	2020	Cell fate analysis showed a greater number of BrdU-labeled cells which co-expressed Prox-1 in the DG of rmTBI-injured mice which coincided with enhanced cFos expression for neuronal activity.	rmtbi	104-109	prospero homeobox 1	Mus musculus	84-90
33200256-9	2021	However, Prox-1DCTKO mice exhibited a significant hypomagnesemia with a profound downregulation of the DCT-specific apical Mg2+ channel TRPM6 and the NaCl cotransporter (NCC) at both mRNA and protein levels.	magnesium ion	123-127	prospero homeobox 1	Mus musculus	9-15
33200256-11	2021	Thus, Prox-1 is a DCT-enriched transcription factor that does not control DCT growth but contributes to the molecular control of DCT-dependent Mg2+ homeostasis in the adult kidney.	magnesium ion	143-147	prospero homeobox 1	Mus musculus	6-12
32119185-0	2020	Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1alpha in liver fibrosis.	curcumol	0-8	prospero homeobox 1	Mus musculus	87-92
28916805-0	2017	An HDAC3-PROX1 corepressor module acts on HNF4alpha to control hepatic triglycerides.	Triglycerides	71-84	prospero homeobox 1	Mus musculus	9-14
30170081-0	2018	Morphine regulates adult neurogenesis and contextual memory extinction via the PKCepsilon/Prox1 pathway.	Morphine	0-8	prospero homeobox 1	Mus musculus	90-95
30170081-1	2018	We have previously reported that the miR-181a/Prox1/Notch1 pathway mediates the effect of morphine on modulating lineage-specific differentiation of adult neural stem/progenitor cells (NSPCs) via a PKCepsilon-dependent pathway, whereas fentanyl shows no such effect.	Morphine	90-98	prospero homeobox 1	Mus musculus	46-51
30170081-1	2018	We have previously reported that the miR-181a/Prox1/Notch1 pathway mediates the effect of morphine on modulating lineage-specific differentiation of adult neural stem/progenitor cells (NSPCs) via a PKCepsilon-dependent pathway, whereas fentanyl shows no such effect.	Fentanyl	236-244	prospero homeobox 1	Mus musculus	46-51
30170081-3	2018	The current study investigated the effect of PKCepsilon/Prox1 on morphine-induced inhibition of adult neurogenesis and drug-associated contextual memory in mice, while the effect of fentanyl was tested simultaneously.	Morphine	65-73	prospero homeobox 1	Mus musculus	56-61
30170081-9	2018	In conclusion, morphine mediates lineage-specific NSPC differentiation, inhibits adult neurogenesis and regulates contextual memory retention via the PKCepsilon/Prox1 pathway, which are implicated in the eventual context-associated relapse.	Morphine	15-23	prospero homeobox 1	Mus musculus	161-166
29213129-5	2017	DT endothelium was Prox1-positive, CD31-positive and LYVE-1-negative, bearing a different molecular signature from blood and true lymphatic vessels.	Thymidine	0-2	prospero homeobox 1	Mus musculus	19-24
31913277-5	2020	In contrast, Prox1-positive endocrine cells appear as primary sensors of cholinergic blockade inducing the expansion of tuft cells, which adopt an enteroendocrine phenotype and contribute to increased mucosal levels of acetylcholine.	Acetylcholine	219-232	prospero homeobox 1	Mus musculus	13-18
28916805-4	2017	The HDAC3-PROX1 module controls the expression of a gene program regulating lipid homeostasis, and hepatic-specific ablation of either component increases triglyceride content in liver.	Triglycerides	155-167	prospero homeobox 1	Mus musculus	10-15
28529477-6	2017	Prox1-immunoreactive amacrine cells expressed glycine, and they formed 35 +- 3% of all glycinergic amacrine cells.	Glycine	46-53	prospero homeobox 1	Mus musculus	0-5
28314928-9	2017	Most hilar Prox1-positive cells at PND16 co-expressed doublecortin (DCX) and calretinin, markers of immature GCs.	doublecortin	54-66	prospero homeobox 1	Mus musculus	11-16
28352669-4	2017	Upon indomethacin challenge, Calcrlfl/fl/Prox1-CreERT2 mice demonstrated persistent inflammation and failure to recover and thrive.	Indomethacin	5-17	prospero homeobox 1	Mus musculus	41-46
27873085-9	2017	Changes to the tamoxifen dose or reporter line with Prox1 CreERT2 caused minimal changes.	Tamoxifen	15-24	prospero homeobox 1	Mus musculus	52-57
26012717-2	2015	Using NPCs cultured from PKCepsilon or beta-arrestin2 knockout mice and the MAPK/ERK kinase inhibitor U0126, we demonstrate that regulation of NPC differentiation via the miR-181a/Prox1/Notch1 pathway exhibits ligand-dependent selectivity.	U 0126	102-107	prospero homeobox 1	Mus musculus	180-185
28024299-5	2017	Mechanistically, the transcription factor PROX1 upregulates CPT1A expression, which increases acetyl coenzyme A production dependent on fatty acid beta-oxidation.	Fatty Acids	136-146	prospero homeobox 1	Mus musculus	42-47
26709696-8	2015	Lysolecithin-induced demyelination injury caused a reduction in CC1+ OLs in homozygous Prox1-/- conditional knockout mice compared to controls.	Lysophosphatidylcholines	0-12	prospero homeobox 1	Mus musculus	87-92
26631740-6	2016	Also, we uncovered substantial deficiency in beta-cells that overexpress Prox1 of the key regulator of beta-cell maturation MafA, several MafA downstream targets required for glucose-stimulated insulin secretion, and genes encoding important components of FGF signaling.	Glucose	175-182	prospero homeobox 1	Mus musculus	73-78
26992918-9	2016	Furthermore, we discovered that Prox1-heterozygosis increases tissue damage and delays recovery from inflammation in pancreata of mice injected with caerulein.	Ceruletide	149-158	prospero homeobox 1	Mus musculus	32-37
24964978-4	2014	This effect was mediated by the Prox1/Notch1 pathway as demonstrated by an increase in Notch1 level in the morphine- but not fentanyl-treated hNPCs and blocked by overexpression of Notch1 siRNA.	Morphine	107-115	prospero homeobox 1	Mus musculus	32-37
25993027-7	2015	Renal hypoosmolality induced by furosemide (NKCC2 inhibitor) inhibited Prox1 expression and delayed maturation of the ascending limb of Henle"s loop.	Furosemide	32-42	prospero homeobox 1	Mus musculus	71-76
24964978-4	2014	This effect was mediated by the Prox1/Notch1 pathway as demonstrated by an increase in Notch1 level in the morphine- but not fentanyl-treated hNPCs and blocked by overexpression of Notch1 siRNA.	Fentanyl	125-133	prospero homeobox 1	Mus musculus	32-37
24964978-5	2014	Overexpression of Prox1 siRNA upregulated Notch1 level and potentiated the morphine-induced lineage changes.	Morphine	75-83	prospero homeobox 1	Mus musculus	18-23
24964978-10	2014	Thus, by modulating Prox1/Notch1 activities via miR-181a, morphine influences the fate of differentiating hNPCs differentiation and therefore the ultimate quantities of mature neurons and astrocytes.	Morphine	58-66	prospero homeobox 1	Mus musculus	20-25
21099229-5	2011	RA-cAMP incubation also promoted the development of CD31+/LYVE-1+/Prox1+ cell clusters.	Tretinoin	0-2	prospero homeobox 1	Mus musculus	66-71
25176150-0	2014	SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.	Cholesterol	101-112	prospero homeobox 1	Mus musculus	28-33
23845607-11	2013	Western blotting shows that VEGF-D, LYVE-1, Prox-1, and VEGFR-3 expression was upregulated in N/B+CDH lung buds in comparison to N/B - CDH or control lung buds at E14.5.	CDw17 antigen	98-101	prospero homeobox 1	Mus musculus	44-50
21099229-5	2011	RA-cAMP incubation also promoted the development of CD31+/LYVE-1+/Prox1+ cell clusters.	Cyclic AMP	3-7	prospero homeobox 1	Mus musculus	66-71
19056879-4	2008	(3282-3291) published in this issue of Genes & Development now shows that continued expression of Prox1 is required to maintain lymphatic endothelial cell identity even in adult mice.	Adenosine Monophosphate	46-49	prospero homeobox 1	Mus musculus	102-107
18502050-4	2008	To further refine our method for identifying key restriction points in adult neurogenesis we here used the first expression of granule cell-specific transcription factor prospero-related homeobox 1 (Prox1) to identify lineage-determined progenitor cells in a nestin-green fluorescent protein (GFP) reporter gene mouse and labeled proliferating precursor cells with bromodeoxyuridine (BrdU).	Bromodeoxyuridine	384-388	prospero homeobox 1	Mus musculus	170-197
18502050-0	2008	Differential 24 h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures.	Kainic Acid	155-166	prospero homeobox 1	Mus musculus	36-41
18502050-4	2008	To further refine our method for identifying key restriction points in adult neurogenesis we here used the first expression of granule cell-specific transcription factor prospero-related homeobox 1 (Prox1) to identify lineage-determined progenitor cells in a nestin-green fluorescent protein (GFP) reporter gene mouse and labeled proliferating precursor cells with bromodeoxyuridine (BrdU).	Bromodeoxyuridine	384-388	prospero homeobox 1	Mus musculus	199-204
18502050-4	2008	To further refine our method for identifying key restriction points in adult neurogenesis we here used the first expression of granule cell-specific transcription factor prospero-related homeobox 1 (Prox1) to identify lineage-determined progenitor cells in a nestin-green fluorescent protein (GFP) reporter gene mouse and labeled proliferating precursor cells with bromodeoxyuridine (BrdU).	Bromodeoxyuridine	365-382	prospero homeobox 1	Mus musculus	170-197
34517095-6	2022	Furthermore, dietary 0.15% L-theanine supplementation significantly increased the mRNA levels of prox1, CaN and NFATc1, the protein levels of prox1, CNA and NFATc1 and the activity of CaN in GAS muscle when compared with the control group.	theanine	27-37	prospero homeobox 1	Mus musculus	97-102
18502050-4	2008	To further refine our method for identifying key restriction points in adult neurogenesis we here used the first expression of granule cell-specific transcription factor prospero-related homeobox 1 (Prox1) to identify lineage-determined progenitor cells in a nestin-green fluorescent protein (GFP) reporter gene mouse and labeled proliferating precursor cells with bromodeoxyuridine (BrdU).	Bromodeoxyuridine	365-382	prospero homeobox 1	Mus musculus	199-204
17217617-8	2006	In mice, xenografts of tumor cells with tetracycline-induced wt-Prox1 formed tumor masses significantly more slowly than control tumors, whereas mutated Prox1 had no effect.	Tetracycline	40-52	prospero homeobox 1	Mus musculus	64-69
34517095-6	2022	Furthermore, dietary 0.15% L-theanine supplementation significantly increased the mRNA levels of prox1, CaN and NFATc1, the protein levels of prox1, CNA and NFATc1 and the activity of CaN in GAS muscle when compared with the control group.	theanine	27-37	prospero homeobox 1	Mus musculus	142-147
35248684-10	2022	MiR-140-5p overexpression decreased the predicted target gene Prox1.	mir-140-5p	0-10	prospero homeobox 1	Mus musculus	62-67
35159256-10	2022	The xenograft volume was decreased and PROX1 expression was increased by rapamycin.	Sirolimus	73-82	prospero homeobox 1	Mus musculus	39-44
35159256-11	2022	These results indicate that PROX1 plays a key role in the anti-proliferative effect of rapamycin and suggest that the increased PROX1 by MTOR inhibition can be used as a useful marker for predicting whether HCC cells can be affected by rapamycin.	Sirolimus	87-96	prospero homeobox 1	Mus musculus	28-33
35159256-11	2022	These results indicate that PROX1 plays a key role in the anti-proliferative effect of rapamycin and suggest that the increased PROX1 by MTOR inhibition can be used as a useful marker for predicting whether HCC cells can be affected by rapamycin.	Sirolimus	87-96	prospero homeobox 1	Mus musculus	128-133
35159256-11	2022	These results indicate that PROX1 plays a key role in the anti-proliferative effect of rapamycin and suggest that the increased PROX1 by MTOR inhibition can be used as a useful marker for predicting whether HCC cells can be affected by rapamycin.	Sirolimus	236-245	prospero homeobox 1	Mus musculus	28-33
35159256-11	2022	These results indicate that PROX1 plays a key role in the anti-proliferative effect of rapamycin and suggest that the increased PROX1 by MTOR inhibition can be used as a useful marker for predicting whether HCC cells can be affected by rapamycin.	Sirolimus	236-245	prospero homeobox 1	Mus musculus	128-133