PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33983546-5	2021	Increased proliferation in response to METH plus HIV was associated with dysregulation of cyclin B1 and cyclin D. Transcriptomic studies indicated that 27 out of the top 30 differentially expressed genes in response to METH plus EcoHIV were targets of the forkhead box O transcriptional factor (FOXO) and primarily FOXO3.	Methamphetamine	39-43	cyclin B1	Mus musculus	90-99
33310327-8	2021	CDK1 and cyclin B1 were reduced in As-exposed GC-1 cells and mouse testes.	Arsenic	35-37	cyclin B1	Mus musculus	9-18
33938783-4	2021	ALA also up-regulated G2/Mitotic-specific cyclin-B1 gene and apoptosis suppressive gene Bcl2 expression (p < 0.05).	Alanine	0-3	cyclin B1	Mus musculus	22-51
33923494-4	2021	Results showed that um-PEA inhibited tumor cell proliferation via peroxisome proliferator-activated receptor alpha and G protein-coupled receptor 55, induced cell cycle arrest in the G2/M phase, possibly through cyclin B1/CDK1 upregulation, and induced DNA fragmentation.	um-pea	20-26	cyclin B1	Mus musculus	212-221
33188406-10	2021	Combined BSp and GTPs synergistically (CIn < 1) downregulated the expression of cyclin B1, D1, and E1 and cyclin-dependent kinase 1, 2, and 4 (P < 0.05) compared with the control group.	bsp	9-12	cyclin B1	Mus musculus	80-89
33520717-7	2020	OTSSP167 treatment reduced the expression of cell cycle G2/M phase-related proteins, Cyclin B1 and Cdc2, while up-regulation the expression of p21 and subsequently induced cell cycle arrest at the G2/M phase.	1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone	0-8	cyclin B1	Mus musculus	85-94
33188406-10	2021	Combined BSp and GTPs synergistically (CIn < 1) downregulated the expression of cyclin B1, D1, and E1 and cyclin-dependent kinase 1, 2, and 4 (P < 0.05) compared with the control group.	Guanosine Triphosphate	17-21	cyclin B1	Mus musculus	80-89
33263014-10	2020	BITC induced G2 arrest and apoptosis, decreasing tumor growth in nude mice by downregulation of cyclin B1 and Cdk1 expression.	benzyl isothiocyanate	0-4	cyclin B1	Mus musculus	96-105
30381745-5	2019	Treatment with 400 muM GA significantly inhibited PCNA and Cyclin B1 expression, however up-regulated BAX and Caspase-3 expression, caused mitochondrial membrane depolarization, activated Caspase-3, and induced DNA damage, thus, markedly increased the numbers of dead cells.	Gallic Acid	23-25	cyclin B1	Mus musculus	59-68
32209841-5	2020	Silibinin slightly triggered apoptosis and significantly induced G2-M cell cycle arrest by downregulating cyclin B1 and CDK1 and increasing expression of p21.	Silybin	0-9	cyclin B1	Mus musculus	106-115
32103981-5	2020	CyclinB1-short hairpin RNA (Sh-cyclinB1) was transfected into HCC cells to knockdown cyclinB1, and the effect of cyclinB1 knockdown on HCC was examined via the MTT assay, colony formation assay, wound healing assay, scratch assay, cell cycle analysis in vitro, and xenograft model in nude mice.	monooxyethylene trimethylolpropane tristearate	160-163	cyclin B1	Mus musculus	0-8
32103981-9	2020	The data of the MTT assay, colony formation assay, and cell cycle analysis indicated that cyclinB1 knockdown inhibited the proliferation of HCC cells.	monooxyethylene trimethylolpropane tristearate	16-19	cyclin B1	Mus musculus	90-98
31809801-4	2020	VERU-111 treatment arrested cell cycle in the G2/M phase and modulated cell cycle regulatory proteins (cyclin B1, p21 p34cdc2 and pcdk1).	R 111	0-8	cyclin B1	Mus musculus	103-112
31698699-7	2019	Additionally, treatment with metformin and 2DG (5 mM) inhibited the Akt/mTOR pathway and down-regulated the cell-cycle-related proteins such as p-cyclin B1 (S147) and cyclins D1 and D2 when compared to cells that were treated with either 2DG or metformin alone.	Metformin	29-38	cyclin B1	Mus musculus	146-155
31698699-7	2019	Additionally, treatment with metformin and 2DG (5 mM) inhibited the Akt/mTOR pathway and down-regulated the cell-cycle-related proteins such as p-cyclin B1 (S147) and cyclins D1 and D2 when compared to cells that were treated with either 2DG or metformin alone.	Deoxyglucose	43-46	cyclin B1	Mus musculus	146-155
30972427-3	2019	Here, CT was shown to inhibit the proliferation of mouse Lewis lung carcinoma (LLC) cells by upregulating p53, downregulating cyclin B1 and Cdc2, and, consequently, inducing G2/M cell-cycle arrest of LLC cells.	cryptotanshinone	6-8	cyclin B1	Mus musculus	126-135
31671317-7	2019	Indox inhibited tumor proliferation accompanied with low levels of nuclear phosphorylated cyclin-dependent kinase (p-CDK) and cyclin B1 in vivo.	indirubin	0-5	cyclin B1	Mus musculus	126-135
30665718-5	2019	PJ34 treatment dramatically down-regulated cyclin B1 expression in NSPCs, but not in MEFs, which was confirmed by a promoter assay.	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride	0-4	cyclin B1	Mus musculus	43-52
30676695-3	2019	In the present study, we investigated whether cyclin B1-mediated cell cycle activation pathway is a contributing factor in developmental isoflurane neurotoxicity.	Isoflurane	137-147	cyclin B1	Mus musculus	46-55
30676695-7	2019	RESULTS: We found that isoflurane exposure leads to upregulated expression of cell cycle-related biomarkers Cyclin B1, Phospho-CDK1(Thr-161), Phospho-n-myc and downregulated Phospho-CDK1 (Tyr-15).	Isoflurane	23-33	cyclin B1	Mus musculus	108-117
31001113-4	2019	We have found that the combination of alteronol and ADM significantly suppressed the expression levels of the cell cycle-related proteins (CDC2 and Cyclin B1) and induced cell cycle arrest at the G2/M phase, leading to cell proliferation inhibition in breast cancer 4T1 cells.	alteronol	38-47	cyclin B1	Mus musculus	148-157
31001113-4	2019	We have found that the combination of alteronol and ADM significantly suppressed the expression levels of the cell cycle-related proteins (CDC2 and Cyclin B1) and induced cell cycle arrest at the G2/M phase, leading to cell proliferation inhibition in breast cancer 4T1 cells.	Doxorubicin	52-55	cyclin B1	Mus musculus	148-157
29911914-9	2018	However, MG132, an inhibitor of anaphase-promoting complex/cyclosome (APC/C), could rescue the prolonged time of GVBD and increase the expression level of CCNB1 of oocytes from the CRS mice.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	9-14	cyclin B1	Mus musculus	155-160
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	cyclin B1	Mus musculus	142-151
30535470-0	2019	Expression of cyclin B1, D1 and K in non-small cell lung cancer H1299 cells following treatment with sulforaphane.	sulforaphane	101-113	cyclin B1	Mus musculus	14-23
30601995-8	2019	Analysis of proapoptotic proteins from tumors of DHA DOX mice showed increased Caspase-10 (by 68%) and BH3 interacting domain death agonist (Bid) (by 50%), decreased B-cell CLL/lymphoma 2 (BCL2) (by 24%), and decreased cell cycle proteins Cyclin B1 and Cdc25c (both by 42%), compared with control mice (P < 0.05).	Docosahexaenoic Acids	49-52	cyclin B1	Mus musculus	239-248
30601995-8	2019	Analysis of proapoptotic proteins from tumors of DHA DOX mice showed increased Caspase-10 (by 68%) and BH3 interacting domain death agonist (Bid) (by 50%), decreased B-cell CLL/lymphoma 2 (BCL2) (by 24%), and decreased cell cycle proteins Cyclin B1 and Cdc25c (both by 42%), compared with control mice (P < 0.05).	Doxorubicin	53-56	cyclin B1	Mus musculus	239-248
30546837-4	2018	Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling.	2hf	22-25	cyclin B1	Mus musculus	154-159
29113340-7	2017	Analgecine enhanced G2/M phase arrest in A549 cells by decreasing cyclinB1 and CDK1.	analgecine	0-10	cyclin B1	Mus musculus	66-74
28600475-5	2017	We investigated its antiproliferative effect in vitro and in vivoResults: CUDC-907 significantly inhibited cellular proliferation in thyroid cancer cell lines, induced G2-M arrest with decreased levels of the checkpoint regulators cyclin B1, AURKA, AURKB, PLK1, and increased p21 and p27.	CUDC-907	74-82	cyclin B1	Mus musculus	231-240
29212221-7	2017	More importantly, CAPE-pNO2 dramatically induced cell apoptosis via significant down-regulation of pro-caspase-3, pro-caspase-9, Bcl-2, Cyclin B1 and Cdc2 and up-regulation of cleaved-caspase-3, Bax, CytoC and P21Cip1.	cape-pno2	18-27	cyclin B1	Mus musculus	136-145
28542354-5	2017	In summary, our data support a model that Brusatol, through the inhibition of Nrf2, modulate Cyclin B1 levels, consequently disturbing proper spindle assembly and chromosome condensation in meiotic oocytes.	brusatol	42-50	cyclin B1	Mus musculus	93-102
28347789-5	2017	Both phosphorylated CDK1 and cyclin B1 levels in 170#3 cells were significantly reduced by treatment with Indox and 5MeOIndox in vitro and in vivo.	indirubin-3'-monoxime	106-111	cyclin B1	Mus musculus	29-38
28347789-5	2017	Both phosphorylated CDK1 and cyclin B1 levels in 170#3 cells were significantly reduced by treatment with Indox and 5MeOIndox in vitro and in vivo.	5-methoxyindirubin 3'-oxime	116-125	cyclin B1	Mus musculus	29-38
28347789-8	2017	These results suggest that one mechanism of 5MeOIndox is to induce G2/M arrest of PDAC cells via inhibition of CDK1/cyclin B1 levels, thereby leading to apoptosis.	5-methoxyindirubin 3'-oxime	44-53	cyclin B1	Mus musculus	116-125
28347789-8	2017	These results suggest that one mechanism of 5MeOIndox is to induce G2/M arrest of PDAC cells via inhibition of CDK1/cyclin B1 levels, thereby leading to apoptosis.	pdac	82-86	cyclin B1	Mus musculus	116-125
28542354-4	2017	Our data demonstrated that Brusatol treatment disrupted oocyte maturation and spindle/chromosome organization by modulating Nrf2-Cyclin B1 pathway, as the influence of Brusatol was compensated by the addition of Nrf2 activation plasmid, and the mRNA and protein levels of Cyclin B1 were severely reduced in oocytes following Nrf2 decline.	brusatol	27-35	cyclin B1	Mus musculus	129-138
28542354-4	2017	Our data demonstrated that Brusatol treatment disrupted oocyte maturation and spindle/chromosome organization by modulating Nrf2-Cyclin B1 pathway, as the influence of Brusatol was compensated by the addition of Nrf2 activation plasmid, and the mRNA and protein levels of Cyclin B1 were severely reduced in oocytes following Nrf2 decline.	brusatol	27-35	cyclin B1	Mus musculus	272-281
27998766-7	2017	After DON treatment, the expression levels of cell cycle-related protein including p38/p-p38, Cdc25C/p-Cdc25C, Cdc2/p-Cdc2 and cyclinB1 were significantly decreased and immunoprecipitation analysis showed that cyclinB1-Cdc2 complex was significantly decreased.	deoxynivalenol	6-9	cyclin B1	Mus musculus	127-135
27998766-7	2017	After DON treatment, the expression levels of cell cycle-related protein including p38/p-p38, Cdc25C/p-Cdc25C, Cdc2/p-Cdc2 and cyclinB1 were significantly decreased and immunoprecipitation analysis showed that cyclinB1-Cdc2 complex was significantly decreased.	deoxynivalenol	6-9	cyclin B1	Mus musculus	210-218
27998766-8	2017	However, the combination of SB203580 (p38 specific inhibitor) and DON treatment significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 and cyclinB1-Cdc2 complex.	SB 203580	28-36	cyclin B1	Mus musculus	151-159
27998766-8	2017	However, the combination of SB203580 (p38 specific inhibitor) and DON treatment significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 and cyclinB1-Cdc2 complex.	SB 203580	28-36	cyclin B1	Mus musculus	164-172
29216642-9	2017	Western blot analysis showed that taurine significantly limited the ionizing radiation-induced down-regulation of CyclinB1 and CDK1, and suppressed activation of Fas/FasL system pathway.	Taurine	34-41	cyclin B1	Mus musculus	114-122
27993978-3	2017	Depletion of CenpH by morpholino injection decreased cyclin B1 levels, resulting in attenuation of maturation-promoting factor (MPF) activation, and severely compromised meiotic resumption.	Morpholinos	22-32	cyclin B1	Mus musculus	53-62
27769816-10	2016	Furthermore, As2O3 altered transcriptional activity of several unmethylated cell cycle regulatory genes including cyclin B1, E1, D1, GADD45A and p21.	Arsenic Trioxide	13-18	cyclin B1	Mus musculus	114-123
27177149-6	2016	SPS induced cell cycle arrest in the G2/M phase by decreasing the expression of cdc25B and cyclin B1.	Sodium phenolsulfonate	0-3	cyclin B1	Mus musculus	91-100
27703271-7	2016	Pioglitazone for 8 weeks completely abrogated the increased VSMC proliferation, along with a reduction of cyclin B1 and cyclin D1 expressions and cardiovascular risk profile in the APN-KO mice.	Pioglitazone	0-12	cyclin B1	Mus musculus	106-115
26474281-5	2015	6-OAP bound Skp1 at sites critical to Skp1-Skp2 interaction, leading to dissociation and proteolysis of oncogenic E3 ligases NIPA, Skp2, and beta-TRCP, and accumulation of their substrates Cyclin B1, P27 and E-Cadherin.	OAP protocol	2-5	cyclin B1	Mus musculus	189-198
27394013-7	2016	Trichostatin A (TSA)-mediated HDAC inhibition led to an increased level of AcH3 and AcH4 along with cyclins B1 and D2.	trichostatin A	0-14	cyclin B1	Mus musculus	100-117
27394013-7	2016	Trichostatin A (TSA)-mediated HDAC inhibition led to an increased level of AcH3 and AcH4 along with cyclins B1 and D2.	trichostatin A	16-19	cyclin B1	Mus musculus	100-117
27008508-10	2016	Further assays showed that puerarin up-regulated the transcription of Cyclin A2, Cyclin B1 and Cdk1 in ES-CMs.	puerarin	27-35	cyclin B1	Mus musculus	81-90
26574435-6	2016	In a liver regeneration model using carbon tetrachloride, PCN treatment enhanced the injury-induced increase in the number of Ki-67-positive nuclei as well as Ccna2 and Ccnb1 mRNA levels in wild-type (WT) but not Pxr-null mice.	Pregnenolone Carbonitrile	58-61	cyclin B1	Mus musculus	169-174
26313006-8	2015	Inhibition of CyclinB1 induction by Cycloheximide or CDK1 activity by Roscovitine significantly prevented FQI-induced mitotic arrest.	Cycloheximide	36-49	cyclin B1	Mus musculus	14-22
26313006-8	2015	Inhibition of CyclinB1 induction by Cycloheximide or CDK1 activity by Roscovitine significantly prevented FQI-induced mitotic arrest.	Roscovitine	70-81	cyclin B1	Mus musculus	14-22
25659430-9	2015	Upon entry into mitosis, Cdk1-cyclin B1-dependent phosphorylation of Ser-1126 renders separase prone to inactivation by aggregation/precipitation.	Serine	69-72	cyclin B1	Mus musculus	30-39
25169503-8	2014	Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex.	Fenofibrate	24-35	cyclin B1	Mus musculus	176-184
25349079-4	2015	RESULTS: Injection of mRNAs coding for CDC25B-Ser351A and/or Cyclin B1-Ser123A shows a more potent maturation-inhibiting ability than their respective wild type.	ser123a	71-78	cyclin B1	Mus musculus	61-70
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser351d	55-62	cyclin B1	Mus musculus	148-157
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser123d	77-84	cyclin B1	Mus musculus	67-76
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser123d	77-84	cyclin B1	Mus musculus	148-157
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser351a	137-144	cyclin B1	Mus musculus	67-76
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser123a	158-165	cyclin B1	Mus musculus	67-76
25349079-5	2015	Co-injection of mRNAs coding for phosphor-mimic CDC25B-Ser351D and Cyclin B1-Ser123D can rescue this prophase I arrest induced by CDC25B-Ser351A or Cyclin B1-Ser123A.	ser123a	158-165	cyclin B1	Mus musculus	148-157
24508230-5	2014	Incubation with aristolochic acid led to profound G2/M arrest in proximal tubular epithelial cells via p53-mediated inactivation of the maturation-promoting complex, CDK1/cyclin-B1.	aristolochic acid I	16-33	cyclin B1	Mus musculus	171-180
24615360-4	2014	RESULTS: High glucose and high insulin, similarly to IGF-I, increased the intracellular level of cyclin A, cyclin B1 and cyclin D1 during myoblast proliferation.	Glucose	14-21	cyclin B1	Mus musculus	107-116
23835136-5	2013	METHODS: We used our newly developed sticky siRNA-based technology delivered with linear polyethyleneimine (PEI) to inhibit the expression of survivin and cyclin B1 both in vitro and in vivo, and addressed the effect of this inhibition on B16-F10 murine melanoma tumor development.	pei	108-111	cyclin B1	Mus musculus	155-164
23764397-4	2013	Treatment with PL resulted in downregulation of EBV-encoded LMP1, cellular Myc, constitutive NF-kappaB activity, and a host of LMP1-Myc-NF-kappaB-regulated target genes including Aurka, Bcat1, Bub1b, Ccnb1, Chek1, Fancd2, Tfrc and Xrcc6.	piperlonguminine	15-17	cyclin B1	Mus musculus	200-205
23785666-7	2013	Exploration of the p53-independent effect indicated that caffeine administration enhanced UVB-induced apoptosis by inhibiting the UVB-induced increase in ATR-mediated formation of phospho-Chk1 (Ser345) and abolishing the UVB-induced decrease in cyclin B1 which resulted in caffeine-induced premature and lethal mitosis in mouse skin.	Caffeine	57-65	cyclin B1	Mus musculus	245-254
23739680-6	2013	Two main cell cycle related proteins cyclin D1 and cyclin B1 were significantly inhibited at the present of EGCG and curcumin.	epigallocatechin gallate	108-112	cyclin B1	Mus musculus	51-60
23739680-6	2013	Two main cell cycle related proteins cyclin D1 and cyclin B1 were significantly inhibited at the present of EGCG and curcumin.	Curcumin	117-125	cyclin B1	Mus musculus	51-60
22498432-8	2012	Cell death was not evident in short forelimb, and ATRA inhibited the expression of Ccnb1 and Ccna1, thus retarding chondrocyte maturation.	Tretinoin	50-54	cyclin B1	Mus musculus	83-88
23588478-4	2013	Treatment with imiquimod induced cell cycle arrest at the G2/M phase in TRMPA-C2 cells, confirmed by the changes of G2/M checkpoint regulators such as reduction of cyclin B1 expression and increase of phospho-CDC2 and p21 in TRAMP-C2 cells treated with imiquimod.	Imiquimod	15-24	cyclin B1	Mus musculus	164-173
22893064-3	2012	The priming action of aspirin on tumor cells was found to be dependent on an altered constitution of tumor microenvironment with respect to decline of acidosis and modulation in the expression of cell cycle and survival regulatory molecules like cyclin B1, cyclin D, bcl-2, bcl-xL, p53, and cytokines: IL-4, IL-10, IFN- gamma &amp; VEGF.	Aspirin	22-29	cyclin B1	Mus musculus	246-255
22444557-7	2012	When oocytes precultured with eCG + CHX were further cultured without eCG and CHX, cyclin B1 first decreased but then, because of the ongoing effects of CHX, increased to a level sufficient to induce GVBD.	Cycloheximide	36-39	cyclin B1	Mus musculus	83-92
22053081-7	2012	Chromatin immunoprecipitation (ChIP) analysis revealed that Ago1 was selectively associated with the Ccnb1 promoter and miR-744 increased enrichment of RNA polymerase II (RNAP II) and trimethylation of histone 3 at lysine 4 (H3K4me3) at the Ccnb1 transcription start site.	Lysine	215-221	cyclin B1	Mus musculus	101-106
22388073-9	2012	The cells treated with piperine (140 and 280 mumol/L) significantly increased the percentage of cells in G(2)/M phase with a reduction in the expression of cyclin B1.	piperine	23-31	cyclin B1	Mus musculus	156-165
21793718-7	2012	Further, cyclin B1 protein expression in oocytes was remarkably inhibited by c-erbB(2) ASODN, c-myb ASODN, and roscovitine.	Roscovitine	111-122	cyclin B1	Mus musculus	9-18
22383461-10	2012	Overexpression of TEX11 in mouse germ-cell-derived GC-1 and GC-2 cells suppressed the cell proliferation and the expression of cFos, Ccnd1, and Ccnb1 that were stimulated by 17beta-estradiol or diarylpropionitrile and elevated the expression level of the proapoptotic Bax gene.	Estradiol	174-190	cyclin B1	Mus musculus	144-149
21692746-6	2012	Tumour cells of aspirin-treated mice were found arrested in G0/G1 phase of the cell cycle and showed nuclear localization of cyclin B1.	Aspirin	16-23	cyclin B1	Mus musculus	125-134
22336910-5	2012	The expression of Cdc25C, Cdc2 and cyclin B1 was decreased in tumor tissues from myriocin-treated mice, while the expression of p53 and p21 (waf1/cip1)  was increased compared with that of the controls.	thermozymocidin	81-89	cyclin B1	Mus musculus	35-44
21993662-6	2012	PL up-regulated the expression of p53 in U2OS cells and p21 in the two osteosarcoma cell lines causing cell cycle arrest by decreasing the expression of murine double minute 2 (MDM2)/cyclin B1 and cyclin D1.	plumbagin	0-2	cyclin B1	Mus musculus	183-192
22014088-7	2011	Magnolol induced G2/M phase cell cycle arrest in A431 cells at 12 h with a decreased expression of cell cycle proteins such as cyclin B1, cyclin A, CDK4, Cdc2 and simultaneous increase in the expression of Cip/p21, a cyclin-dependent kinase inhibitor.	magnolol	0-8	cyclin B1	Mus musculus	127-136
20820782-11	2011	Regulation of Cyclin A1, Cyclin B1 and Cdk1/cdc2 expression might contribute to the different cell cycle patterns in B16 and B16BL6 after Cryptotanshinone treatment.	cryptotanshinone	138-154	cyclin B1	Mus musculus	25-34
21645154-7	2011	Expressions of cdc25C, cyclin B1 and cdc2 were decreased in the cells after exposure to myriocin, while expression of p53 and p21(waf1/cip1) was increased.	thermozymocidin	88-96	cyclin B1	Mus musculus	23-32
21645154-9	2011	CONCLUSIONS: Our results suggest that inhibition of sphingolipid synthesis by myriocin in melanoma cells may inhibit expression of cdc25C or activate expression of p53 and p21(waf1/cip1) , followed by inhibition of cyclin B1 and cdc2, resulting in G(2) /M arrest of the cell cycle and cell population growth inhibition.	Sphingolipids	52-64	cyclin B1	Mus musculus	215-224
21645154-9	2011	CONCLUSIONS: Our results suggest that inhibition of sphingolipid synthesis by myriocin in melanoma cells may inhibit expression of cdc25C or activate expression of p53 and p21(waf1/cip1) , followed by inhibition of cyclin B1 and cdc2, resulting in G(2) /M arrest of the cell cycle and cell population growth inhibition.	thermozymocidin	78-86	cyclin B1	Mus musculus	215-224
21505179-0	2011	Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.	Caffeine	0-8	cyclin B1	Mus musculus	74-83
21383018-5	2011	We observed that PP2A inhibition using okadaic acid induced events normally observed at fertilization: degradation of the APC/C substrates cyclin B1 and securin resulting from loss of the APC/C inhibitor Emi2.	Okadaic Acid	39-51	cyclin B1	Mus musculus	139-148
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	31-39	cyclin B1	Mus musculus	153-162
21505179-6	2011	Treatment of mice with topical caffeine significantly diminished phospho-Chk1 (Ser317) staining and increased the number of mitotic cells that expressed cyclin B1 and caspase 3 in tumors, consistent with caffeine-induced lethal mitosis selectively in tumors.	Caffeine	204-212	cyclin B1	Mus musculus	153-162
21304051-8	2011	2HF reduced cyclin B1 and CDK4 levels and induced G2/M phase arrest in VHL-mutant RCC.	2'-hydroxyflavanone	0-3	cyclin B1	Mus musculus	12-21
19926639-0	2010	Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice.	Caffeine	23-31	cyclin B1	Mus musculus	117-126
20384627-10	2010	At 15 Gy, expression of CDC2-Tyr15-P in the Caff + IR group (26.0 +/- 8.9%) was significantly lower than in the IR alone group (68.4 +/- 10.6%), expression of cyclinB1 and proportion of TUNEL-positive cells in the Caff + IR group (30.4 +/- 8.7% and 59.2 +/- 9.5%, respectively) was significantly higher than in the IR alone group (7.0 +/- 3.7% and 24.2 +/- 7.2%, respectively), expression of caspase-3 was consistent with the TUNEL staining results.	Caffeine	44-48	cyclin B1	Mus musculus	159-167
21084261-10	2010	Also, gefitinib reduced EGFR, proliferating cell nuclear antigen, cyclin D1, C(2)GNT, RhoA, beta-catenin, p38, phospho-extracellular signal-regulated kinase, caveolin-1, and mucin and increased cyclin B1 in the pancreatic lesions/PDAC.	Gefitinib	6-15	cyclin B1	Mus musculus	194-203
20660090-4	2010	Consistent with the ability of the SAC to inhibit cyclin B1 degradation by blocking activation of the anaphase-promoting complex, we could also observe a rescue in cyclin B1 degradation when ZM447439 was added to nocodazole-treated oocytes.	4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline	191-199	cyclin B1	Mus musculus	50-59
20660090-4	2010	Consistent with the ability of the SAC to inhibit cyclin B1 degradation by blocking activation of the anaphase-promoting complex, we could also observe a rescue in cyclin B1 degradation when ZM447439 was added to nocodazole-treated oocytes.	4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline	191-199	cyclin B1	Mus musculus	164-173
20660090-4	2010	Consistent with the ability of the SAC to inhibit cyclin B1 degradation by blocking activation of the anaphase-promoting complex, we could also observe a rescue in cyclin B1 degradation when ZM447439 was added to nocodazole-treated oocytes.	Nocodazole	213-223	cyclin B1	Mus musculus	164-173
20483353-6	2010	In addition, cucurbitacin B/cisplatin treated Hep-2 cells also demonstrated a significant reduction in Bcl-2 and Cyclin B1 protein levels compared to single agent cucurbitacin B or cisplatin treated cells.	cucurbitacin B	13-27	cyclin B1	Mus musculus	113-122
20483353-6	2010	In addition, cucurbitacin B/cisplatin treated Hep-2 cells also demonstrated a significant reduction in Bcl-2 and Cyclin B1 protein levels compared to single agent cucurbitacin B or cisplatin treated cells.	Cisplatin	28-37	cyclin B1	Mus musculus	113-122
20683012-5	2010	RT-qPCR was performed to confirm whether E7 biomarkers would be modulated by melphalan treatment in E7-Tg mice, revealing that up-regulated E7 markers such as cyclin B1, CD166, and actin alpha1 were down-regulated, whereas expression of down-regulated E7 markers such as vimentin was restored by melphalan treatment.	Melphalan	77-86	cyclin B1	Mus musculus	159-168
19926639-3	2010	Western blot analysis indicated that treatment of p53(-/-) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice.	Caffeine	69-77	cyclin B1	Mus musculus	124-133
19184021-6	2009	About 10 microg/mL DHCB was found to decrease cyclin-A, and especially in cyclin-B1.	dihydrocucurbitacin B	19-23	cyclin B1	Mus musculus	74-83
19184021-9	2009	CONCLUSIONS: Dihydrocucurbitacin-B reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of the actin cytoskeleton, arresting B16F10 cells in G2/M phase.	dihydrocucurbitacin B	13-34	cyclin B1	Mus musculus	117-126
19010926-7	2008	The dorsolateral prostate from DATS-treated TRAMP mice exhibited decreased cellular proliferation in association with induction of cyclinB1 and securin protein levels, and suppression of the expression of neuroendocrine marker synaptophysin.	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	31-35	cyclin B1	Mus musculus	131-139
19095349-7	2009	Marchantin C-treated xenografts showed decreased microtubules, Bcl-2 and increased cyclin B1, Bax, caspase-3, indicating that marchantin C possess the same ability to induce microtubules depolymerization and tumor cell apoptosis in tumor-bearing mice as in vitro.	marchantin C	0-12	cyclin B1	Mus musculus	83-92
19470789-5	2009	DIM inhibited survivin mRNA expression and promoted survivin protein degradation through inhibition of p34(cdc2)-cyclin B1-mediated survivin Thr(34) phosphorylation.	Threonine	141-144	cyclin B1	Mus musculus	113-122
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin B1	Mus musculus	90-95
18843087-9	2009	Addition of cyclopamine significantly affected levels of Gli1, Igfbp6, Ccnd2 (cyclin D2), Ccnb1 (cyclin B1), Spp1, Kit, and Amh mRNAs; these genes have been shown previously to be expressed in Sertoli and germ cells.	cyclopamine	12-23	cyclin B1	Mus musculus	97-106
18381462-11	2008	Our studies indicate that administration of caffeine enhances the removal of DNA-damaged cells by inhibiting the ATR-mediated phosphorylation of Chk1 and prematurely increasing the number of cyclin B1-containing cells that undergo lethal mitosis.	Caffeine	44-52	cyclin B1	Mus musculus	191-200
18490075-8	2008	Potentially additive effects of bevacizumab plus rapamycin included reductions in vascular endothelial growth factor expression, cyclin D1, and cyclin B1.	Sirolimus	49-58	cyclin B1	Mus musculus	144-153
18393292-6	2008	These observations were further confirmed in vivo by the reciprocal control of TIS21 expression and FoxM1 phosphorylation in the diethylnitrosamine-induced HCCs and TIS21(-/-) mouse embryonic fibroblast (MEF), in addition to increased expression of cyclin B1 and cdk1 activity.	Diethylnitrosamine	129-147	cyclin B1	Mus musculus	249-258
18445658-8	2008	The protein levels of cyclin B1 and E were also decreased by gallic acid feeding.	Gallic Acid	61-72	cyclin B1	Mus musculus	22-31
18381462-4	2008	When given in the drinking water for 1 to 2 weeks before UVB, caffeine (0.4 mg/mL) markedly inhibited the UVB-induced phosphorylation of Chk1 on Ser(345) and caused premature expression of cyclin B1 in the epidermis.	Caffeine	62-70	cyclin B1	Mus musculus	189-198
18559535-5	2008	High expression of cyclin B1, but not p53, c-myc, and CDC25A, was detected in chloramphenicol-treated activated T cells, which may relate to abnormal cell differentiation.	Chloramphenicol	78-93	cyclin B1	Mus musculus	19-28
18288364-9	2008	Furthermore, MAPK phosphorylation and cyclin B1 synthesis in oocytes were inhibited remarkably when oocytes were treated with c-erbB(2) ASODN, c-myb ASODN, PD98059 and roscovitine.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	156-163	cyclin B1	Mus musculus	38-47
18288364-9	2008	Furthermore, MAPK phosphorylation and cyclin B1 synthesis in oocytes were inhibited remarkably when oocytes were treated with c-erbB(2) ASODN, c-myb ASODN, PD98059 and roscovitine.	Roscovitine	168-179	cyclin B1	Mus musculus	38-47
17667592-7	2007	Treatment with 17-allylamino-17-demethoxygeldanamycin arrested GL261 cells in the G2 phase of the cell cycle associated with the downregulation of cyclin B1.	tanespimycin	15-53	cyclin B1	Mus musculus	147-156
18176113-9	2008	Our data identified two upstream targets leading to the inactivity of the cyclin B1/Cdc2 complex, which explained the arrest in the G2/M phase following SLXM-2 treatment.	SLXM-2	153-159	cyclin B1	Mus musculus	74-83
18006855-8	2007	A dose-dependent decrease was also observed in cyclin B1, cyclin E, and cyclin A protein levels by silibinin.	Silybin	99-108	cyclin B1	Mus musculus	47-56
17320365-0	2007	Dietary selenium variation-induced oxidative stress modulates CDC2/cyclin B1 expression and apoptosis of germ cells in mice testis.	Selenium	8-16	cyclin B1	Mus musculus	67-76
17876044-4	2007	AZD6244-inhibited tumor growth was associated with increased apoptosis, inactivation of ERK1/2, inhibition of cell proliferation, and down-regulation of cell cycle regulators, including cyclin D1, cdc-2, cyclin-dependent kinases 2 and 4, cyclin B1, and c-Myc.	AZD 6244	0-7	cyclin B1	Mus musculus	238-247
17320365-3	2007	Because of the involvement of CDC2 and cyclin B1 in cell cycle regulation and their plausible role in apoptosis, the present study aimed to investigate the possibility that selenium (Se)-induced oxidative-stress-mediated modulations of these cell cycle regulators cause DNA damage and apoptosis in germ cells.	Selenium	173-181	cyclin B1	Mus musculus	39-48
17320365-3	2007	Because of the involvement of CDC2 and cyclin B1 in cell cycle regulation and their plausible role in apoptosis, the present study aimed to investigate the possibility that selenium (Se)-induced oxidative-stress-mediated modulations of these cell cycle regulators cause DNA damage and apoptosis in germ cells.	Selenium	183-185	cyclin B1	Mus musculus	39-48
17127414-11	2007	Sodium butyrate decreases cyclin B1 and Cdk4 expression, which would be associated with LEPCs growth arrest shortly after treatment.	Butyric Acid	0-15	cyclin B1	Mus musculus	26-35
17408638-7	2007	Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.	dss	164-167	cyclin B1	Mus musculus	240-249
17160696-0	2007	Inhibition of CDC2/Cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21.	Selenium	44-52	cyclin B1	Mus musculus	19-28
17160696-2	2007	Because of the crucial involvement of CDC2, Cyclin B1, Cdc25c, and p21 in cell cycle regulation, the present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 may cause modulations in the CDC2/Cyclin B1 complex responsible for G2/M phase checkpoint during meiosis I of spermatogenesis.	Selenium	161-169	cyclin B1	Mus musculus	44-53
17160696-2	2007	Because of the crucial involvement of CDC2, Cyclin B1, Cdc25c, and p21 in cell cycle regulation, the present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 may cause modulations in the CDC2/Cyclin B1 complex responsible for G2/M phase checkpoint during meiosis I of spermatogenesis.	Selenium	161-169	cyclin B1	Mus musculus	273-282
17160696-2	2007	Because of the crucial involvement of CDC2, Cyclin B1, Cdc25c, and p21 in cell cycle regulation, the present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 may cause modulations in the CDC2/Cyclin B1 complex responsible for G2/M phase checkpoint during meiosis I of spermatogenesis.	Selenium	171-173	cyclin B1	Mus musculus	273-282
17160696-9	2007	These findings suggest that under the influence of Se-induced oxidative stress, the down regulation of CDC2/Cyclin B1 complex is mediated through changes in Cdc25c and p21 leading to the cell cycle arrest and thus providing new dimensions to the molecular mechanisms underlying male infertility.	Selenium	51-53	cyclin B1	Mus musculus	108-117
16640786-4	2006	CONCLUSION: These results are in line with studies reporting the role of p53 as a post-transcriptional regulator of cyclin B1 protein and confirm that dysregulation of cyclin B1 promote radiation-induced MC.	Methylcholanthrene	204-206	cyclin B1	Mus musculus	168-177
16924665-0	2006	Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein.	Genistein	176-185	cyclin B1	Mus musculus	111-120
16924665-4	2006	RESULTS: The sustained G2/M arrest by genistein in TRAMP-C2 cells is associated with increased phospho-cdc2(Tyr15), decreased cdc2 protein, and cytoplasmic retention of cyclinB1, resulting in decreased cdc2 kinase activity independently of p21.	Genistein	38-47	cyclin B1	Mus musculus	169-177
15716349-4	2005	The pachytene arrest was accompanied by an inefficient exit from proliferation, increased apoptosis and an abnormal nuclear localization of the G2-M cell cycle regulator cyclin B1, but was not associated with apparent chromosomal or recombination defects.	pachytene	4-13	cyclin B1	Mus musculus	170-179
15935813-13	2005	However, when one examines the genes after benzene exposure without p53 gene participation (i.e., p53 was knocked out), various cell cycle-related genes expressed during and after benzene exposure are identified, such as cyclin B1, cyclin D3 and growth hormone in the bone marrow.	Benzene	43-50	cyclin B1	Mus musculus	221-230
15935813-13	2005	However, when one examines the genes after benzene exposure without p53 gene participation (i.e., p53 was knocked out), various cell cycle-related genes expressed during and after benzene exposure are identified, such as cyclin B1, cyclin D3 and growth hormone in the bone marrow.	Benzene	180-187	cyclin B1	Mus musculus	221-230
16078561-0	2005	[Effect of full-length cyclin B1 antisense cDNA on chemosensitivity of lewis lung carcinoma cells to gemicitabine in vitro and in vivo].	gemicitabine	101-113	cyclin B1	Mus musculus	23-32
16078561-1	2005	OBJECTIVE: To evaluate the effect of full-length cyclin B1 antisense cDNA (AS-CLB1) on chemosensitivity of Lewis lung carcinoma cells (LL/2) to gemicitabine (GEM) in vitro and in vivo and hence provide a therapeutic regiment for treating non-small cell lung (NSCL) cancer using AS-CLB1 combined with GEM.	gemicitabine	144-156	cyclin B1	Mus musculus	49-58
15280554-4	2004	Microinjection of cyclin B1-GFP accelerated germinal vesicle breakdown (GVBD) and, as previously described, overrides cAMP-mediated meiotic arrest.	Cyclic AMP	118-122	cyclin B1	Mus musculus	18-27
15327787-8	2004	The expression of cyclin B1 and the phosphorylation of MAPK/p90rsk could still be detected in ALLN or MG-132-treated oocytes even at 8 h after parthenogenetic activation or insemination, which may account for the inhibition of PB2 emission and pronuclear formation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	102-108	cyclin B1	Mus musculus	18-27
15280554-9	2004	Import was revealed by the finding that cyclin B1-GFP accumulated in the GV when export was inhibited using leptomycin B.	leptomycin B	108-120	cyclin B1	Mus musculus	40-49
11566743-8	2001	However, when two-cell blocked embryos were treated with okadaic acid, an activator of Cdc2 kinase, part of cyclin B1 in the embryos translocated into the nucleus.	Okadaic Acid	57-69	cyclin B1	Mus musculus	108-117
14562407-6	2003	The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22 treated with resveratrol whereas the expression of cyclin D1 protein did not change.	Resveratrol	125-136	cyclin B1	Mus musculus	27-36
14562407-8	2003	The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein.	Resveratrol	40-51	cyclin B1	Mus musculus	143-151
12668277-6	2003	This genistein-induced G2/M arrest in vitro was associated with a significant increase in the protein expression of phosphorylated p34(cdc2) and of cyclin B1.	Genistein	5-14	cyclin B1	Mus musculus	148-157
15057144-7	2004	TQ-induced growth inhibition in I7 cells by inducing G2/M cell-cycle arrest, which was associated with an increase in the expression of the tumor suppressor protein p53 and a decrease in cyclin B1 protein.	thymoquinone	0-2	cyclin B1	Mus musculus	187-196
14562407-1	2003	AIM: To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine.	Resveratrol	41-52	cyclin B1	Mus musculus	130-139
12135628-9	2002	In addition, the protein levels of cyclin D1, CDK4, PCNA, c-myc, and mdm2, and cyclin B1 mRNA level were higher in MNNG+CdCl2 group than control and MNNG group.	Cadmium Chloride	120-125	cyclin B1	Mus musculus	79-88
11606477-7	2001	The G0/G1 block caused by celecoxib could be attributed to a decreased expression of cyclin A, cyclin B1, and cyclin-dependent kinase-1 and an increased expression of the cell cycle inhibitory proteins p21Waf1 and p27Kip1.	Celecoxib	26-35	cyclin B1	Mus musculus	95-104
11566743-9	2001	Moreover, treatment with butyrolactone I, a specific inhibitor of Cdc2 kinase, inhibits nuclear translocation of cyclin B1 in those embryos.	4-Butyrolactone	25-38	cyclin B1	Mus musculus	113-122
10414604-7	1999	Thus, it is likely that higher concentrations of ethanol affect the elongation, contraction, and formation of the spindle microtubules of L929 cells dose-dependently and also disrupt the correlation between microtubule organization and the synthesis and degradation of cyclin B1, thereby delaying the progress of karyokinesis, which may lead to an ethanol-induced G2+M block.	Ethanol	49-56	cyclin B1	Mus musculus	269-278
10559244-1	1999	Okadaic acid (OA) causes meiotic progression and chromosome condensation in cultured pachytene spermatocytes and an increase in maturation promoting factor (cyclin B1/cdc2 kinase) activity, as evaluated by H1 phosphorylative activity in anti-cyclin B1 immunoprecipitates.	Okadaic Acid	0-12	cyclin B1	Mus musculus	157-166
10559244-1	1999	Okadaic acid (OA) causes meiotic progression and chromosome condensation in cultured pachytene spermatocytes and an increase in maturation promoting factor (cyclin B1/cdc2 kinase) activity, as evaluated by H1 phosphorylative activity in anti-cyclin B1 immunoprecipitates.	Okadaic Acid	0-12	cyclin B1	Mus musculus	242-251
11401401-7	2001	Moreover, overexpression of cyclin B1 or B2 was able to bypass the dbcAMP-induced germinal vesicle block, but only the cyclin B1 mRNA-microinjected oocytes did not extrude their first polar body.	Bucladesine	67-73	cyclin B1	Mus musculus	28-37
10414604-7	1999	Thus, it is likely that higher concentrations of ethanol affect the elongation, contraction, and formation of the spindle microtubules of L929 cells dose-dependently and also disrupt the correlation between microtubule organization and the synthesis and degradation of cyclin B1, thereby delaying the progress of karyokinesis, which may lead to an ethanol-induced G2+M block.	Ethanol	348-355	cyclin B1	Mus musculus	269-278
9633514-4	1998	Kinetic analysis showed that the signs of apoptosis were observed not until 60 h of continued GCV treatment and preceded first by a rise in p53 protein level in 12 h and then by S-phase/G2-phase cell cycle arrest associated with corresponding increases in the level of cyclin B1 protein but no apparent change in protein level of Bax or Cdc2.	Ganciclovir	94-97	cyclin B1	Mus musculus	269-278
10206738-0	1998	Cyclic AMP delays G2 progression and prevents efficient accumulation of cyclin B1 proteins in mouse macrophage cells.	Cyclic AMP	0-10	cyclin B1	Mus musculus	72-81
10206738-6	1998	Initial induction and accumulation of cyclin B1 mRNA were not hampered, but the half life of cyclin B1 proteins was significantly shorter during G2 phase in the presence of cAMP-elevating agents compared with that of the cells blocked from progressing through M phase by nocodazole.	Cyclic AMP	173-177	cyclin B1	Mus musculus	93-102
10206738-6	1998	Initial induction and accumulation of cyclin B1 mRNA were not hampered, but the half life of cyclin B1 proteins was significantly shorter during G2 phase in the presence of cAMP-elevating agents compared with that of the cells blocked from progressing through M phase by nocodazole.	Nocodazole	271-281	cyclin B1	Mus musculus	93-102
9224673-10	1997	Microinjection of either p34cdc2 or cyclin B1 mRNAs accelerated meiotic reinitiation of okadaic acid-treated incompetent oocytes.	Okadaic Acid	88-100	cyclin B1	Mus musculus	36-45
34086879-9	2021	IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control.	Iodoacetic Acid	0-3	cyclin B1	Mus musculus	146-151
8968050-10	1996	In conclusion, we present evidence that apigenin induces a reversible G2/M arrest in cultured keratinocytes, the mechanism of which is in part due to inhibition of the mitotic kinase activity of p34cd2, and perturbation of cyclin B1 levels.	Apigenin	40-48	cyclin B1	Mus musculus	223-232
8622633-0	1996	Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells.	Doxorubicin	110-121	cyclin B1	Mus musculus	80-89
8622633-4	1996	We then studied the effect of Dox on the p34cdc2/cyclin B1 complex because it plays a key role in regulating G2/M phase transition.	Doxorubicin	30-33	cyclin B1	Mus musculus	49-58
8622633-9	1996	In contrast, Dox treatment was found to induced cyclin B1 accumulation as a result of stimulating its synthesis and inhibiting its degradation.	Doxorubicin	13-16	cyclin B1	Mus musculus	48-57
8622633-11	1996	Our results suggest that anthracycline-induced cytotoxicity is cell cycle dependent and is mediated, at least in part, by disturbance of the regulation of p34cdc2/cyclin B1 complex, thus leading to G2/M phase arrest.	Anthracyclines	25-38	cyclin B1	Mus musculus	163-172
34822792-9	2022	The cells were treated with 0, 100, 200 and 400 muM MnCl2 for 24 h. Here, we found that occupational Mn exposure significantly increased Mn levels in the seminal plasma of male workers, while decreased sperm density, semen quality, and the levels of YTHDC2, CCNB1, and CCNB2.	manganese chloride	52-57	cyclin B1	Mus musculus	258-263
11682060-6	2001	Transient reporter assays in the dox-inducible lines and upon co-transfection with a constitutive FoxM1 expression plasmid suggest that FoxM1 can activate the cyclin B1 promoter.	Doxycycline	33-36	cyclin B1	Mus musculus	159-168
34820015-6	2022	Inhibiting the tumor necrosis factor receptor-associated protein 1/phosphorylated-extracellular-regulated protein kinases1/2/cell division cycle 25 homolog C/cyclin-dependent kinase-1/cyclin B1 pathway was indispensable to the combined treatment with luteolin and oxaliplatin to induce G2/M cell cycle arrest.	Luteolin	251-259	cyclin B1	Mus musculus	184-193
34820015-6	2022	Inhibiting the tumor necrosis factor receptor-associated protein 1/phosphorylated-extracellular-regulated protein kinases1/2/cell division cycle 25 homolog C/cyclin-dependent kinase-1/cyclin B1 pathway was indispensable to the combined treatment with luteolin and oxaliplatin to induce G2/M cell cycle arrest.	Oxaliplatin	264-275	cyclin B1	Mus musculus	184-193
35504548-4	2022	Further analysis indicated that zearalenone caused the decrease of Cyclin B1 and CDK1 expression, indicating MPF activity was affected, which further induced G2/M arrest, and this could be rescued by the inhibition of Wee1 activity.	Zearalenone	32-43	cyclin B1	Mus musculus	67-76
34361649-4	2021	Hispolon also induced cell cycle G2/M phase arrest in GBM cells, as supported by flow cytometry analysis and confirmed by a decrease in cyclin B1, cdc2, and cdc25c protein expressions in a dose- and time-dependent manner.	hispolon	0-8	cyclin B1	Mus musculus	136-145
35509628-7	2022	Furthermore, HDS-2 and HDS-3 potentiated paclitaxel-induced cytotoxicity by 19.1-22.45% (P < 0.05) and 10.52-18.03% (P < 0.05), respectively, inhibited the expression of cyclinB1, Bcl-2, and pMCL-1, and increased the percentage of necrosis cell in the condition of paclitaxel exposure.	Paclitaxel	41-51	cyclin B1	Mus musculus	170-178
35439335-5	2022	Bendamustine arrested NKTCL cells in G2/M phase, with downregulation of expression of cyclin B1 and upregulation of expression of p-cdc2, p-cdc25c and p-P53.	Bendamustine Hydrochloride	0-12	cyclin B1	Mus musculus	86-95
35123992-9	2022	Besides, Z-GS delayed G2/M cycle arrest by promoting the expressions of CDK1 and CyclinB1.	pregna-4,17-diene-3,16-dione	9-13	cyclin B1	Mus musculus	81-89
35074488-13	2022	Consistent with the in vitro results, DHT significantly delayed tumor growth in HO8910PM and ES2 xenograft nude mice, decreased tumor marker HE4 and CA125 levels, reversed the abnormally expressed proteins including Ki67, Nrf2, p62, Keap1, Bcl-2, CyclinB1, Cdc-2, and antioxidant enzymes SOD, CAT in vivo.	Dihydrotestosterone	38-41	cyclin B1	Mus musculus	247-255