PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34839122-5	2022	Peritumorally-injected BALLkine-2 enhances intratumoral lymphocyte infiltration without inducing Treg development and more effectively synergizes with PD-1 blockade than high-dose rIL-2 administration in B16F10 melanoma model.	ballkine-2	23-33	spermatogenesis associated 2	Homo sapiens	151-155
34242660-3	2022	Ferroptosis, a cell death modality triggered by iron-dependent lipid peroxidation, reportedly participates in cancer pathogenesis and can mediate the effect of anti-PD-1 immunotherapy in melanoma.	Iron	48-52	spermatogenesis associated 2	Homo sapiens	165-169
34565560-3	2022	(2021) identify the CAMKK2-adenosine monophosphate-activated protein kinase-NRF2 signaling axis as a negative regulator of ferroptosis and showed that inhibiting CAMKK2 increases the efficacy of anti-PD-1 therapy.	Adenosine	27-36	spermatogenesis associated 2	Homo sapiens	200-204
34766776-5	2021	For NO release, the redox transformation of Pd species comes into play and Pd1+ species are suggested to transform into cationic Pd2+, (PdOH)+, or (Pd-O-Pd)2+ species, all of which show significantly reduced NO binding (-116, -153, and -117 kJ/mol, respectively) as compared to Pd1+.	pdoh	136-140	spermatogenesis associated 2	Homo sapiens	75-78
34571084-6	2021	Moreover, IR780/DPPC/BMS initiated gel-liquid crystal phase transition under laser irradiation, accelerating the disintegration of lipid bilayer structure and leading to the responsive release of BMS, which would reverse the tumor immunosuppression state by blocking PD-1/PD-L1 pathway for a long term.	1,2-Dipalmitoylphosphatidylcholine	16-20	spermatogenesis associated 2	Homo sapiens	267-271
34607937-3	2021	We hypothesized that the expression of PD-1 on Tregs would lead to enhanced suppressive function of Tregs and worsen antitumor immunity during PD-1 blockade.	tregs	47-52	spermatogenesis associated 2	Homo sapiens	39-43
34607937-3	2021	We hypothesized that the expression of PD-1 on Tregs would lead to enhanced suppressive function of Tregs and worsen antitumor immunity during PD-1 blockade.	tregs	47-52	spermatogenesis associated 2	Homo sapiens	143-147
34607937-3	2021	We hypothesized that the expression of PD-1 on Tregs would lead to enhanced suppressive function of Tregs and worsen antitumor immunity during PD-1 blockade.	tregs	100-105	spermatogenesis associated 2	Homo sapiens	39-43
34737749-8	2021	In both patients and controls, MAIT cells expressed high levels of the immune checkpoint molecule PD-1 at rest, while upregulation of PD-1 in response to the MR-1 ligand 5-amino-6D-ribitylaminouracil (5-A-RU) was greater in patients.	5-amino-6-D-ribitylaminouracil	170-199	spermatogenesis associated 2	Homo sapiens	134-138
34737749-8	2021	In both patients and controls, MAIT cells expressed high levels of the immune checkpoint molecule PD-1 at rest, while upregulation of PD-1 in response to the MR-1 ligand 5-amino-6D-ribitylaminouracil (5-A-RU) was greater in patients.	5-amino-6-D-ribitylaminouracil	201-207	spermatogenesis associated 2	Homo sapiens	134-138
35148086-5	2022	The catalytic reaction efficiencies of Pd@1-8 were higher than that of Pd/C (5 wt %) in the hydrogenation reaction of p-nitrophenol (p-NP).	4-nitrophenol	118-131	spermatogenesis associated 2	Homo sapiens	39-45
34676046-4	2021	Using human cytotoxic T-cell line TALL-104 injected intraperitoneally into immunodeficient NCRU-nude athymic mice bearing mismatch repair-deficient (MMR-d) human colon carcinoma HCT116 p53-null (but not wild-type p53) tumor xenograft, we observed accelerated tumor growth after PD-1 blockade with pembrolizumab administration.	tall-104	34-42	spermatogenesis associated 2	Homo sapiens	278-282
34339213-6	2021	The 1,5-cyclooctadiene (COD) ligand contained in the precatalyst CODPd(CH2TMS)2 (Pd1) was shown to be a beneficial additive.	1,5-cyclooctadiene	4-22	spermatogenesis associated 2	Homo sapiens	81-84
34339213-6	2021	The 1,5-cyclooctadiene (COD) ligand contained in the precatalyst CODPd(CH2TMS)2 (Pd1) was shown to be a beneficial additive.	1,5-cyclooctadiene	24-27	spermatogenesis associated 2	Homo sapiens	81-84
34315723-8	2021	CONCLUSIONS: Tumor-specific MHC-II has strong candidacy as a specific biomarker of anti-PD-1/L1 immunotherapy benefit when added to standard NAC in HER2-negative breast cancer.	nac	141-144	spermatogenesis associated 2	Homo sapiens	88-92
35397952-18	2022	PATIENT SUMMARY: We evaluated the efficacy and safety of the anti-PD-1 antibody pembrolizumab combined with the chemotherapy drug docetaxel and the steroid prednisone for patients with metastatic prostate cancer resistant to androgen deprivation therapy , and who never received chemotherapy.	Prednisone	156-166	spermatogenesis associated 2	Homo sapiens	66-70
35603906-13	2022	The data suggest that cabozantinib may be more effective than nivolumab in the third-line setting, possibly related to an ability of cabozantinib to overcome resistance to PD-1 blockade.	cabozantinib	133-145	spermatogenesis associated 2	Homo sapiens	172-176
35551203-0	2022	Photo-thermo semi-hydrogenation of acetylene on Pd1/TiO2 single-atom catalyst.	Acetylene	35-44	spermatogenesis associated 2	Homo sapiens	48-51
35551203-0	2022	Photo-thermo semi-hydrogenation of acetylene on Pd1/TiO2 single-atom catalyst.	titanium dioxide	52-56	spermatogenesis associated 2	Homo sapiens	48-51
35551203-4	2022	Here, we report a simple strategy to construct Pd1/TiO2 SACs by selectively encapsulating the co-existed small amount of Pd nanoclusters/nanoparticles based on their different strong metal-support interaction (SMSI) occurrence conditions.	Palladium	121-123	spermatogenesis associated 2	Homo sapiens	47-50
35551203-4	2022	Here, we report a simple strategy to construct Pd1/TiO2 SACs by selectively encapsulating the co-existed small amount of Pd nanoclusters/nanoparticles based on their different strong metal-support interaction (SMSI) occurrence conditions.	Metals	183-188	spermatogenesis associated 2	Homo sapiens	47-50
35175415-1	2022	Pd(II) complexes (Pd1, Pd2, and Pd3) were synthesized for the first time using asymmetric isatin bisthiocarbohydrazone ligands and PdCl2(PPh3)2.	poly-4-dioxan-2-one	0-6	spermatogenesis associated 2	Homo sapiens	18-21
35175415-1	2022	Pd(II) complexes (Pd1, Pd2, and Pd3) were synthesized for the first time using asymmetric isatin bisthiocarbohydrazone ligands and PdCl2(PPh3)2.	isatin bisthiocarbohydrazone	90-118	spermatogenesis associated 2	Homo sapiens	18-21
35148086-5	2022	The catalytic reaction efficiencies of Pd@1-8 were higher than that of Pd/C (5 wt %) in the hydrogenation reaction of p-nitrophenol (p-NP).	4-nitrophenol	133-137	spermatogenesis associated 2	Homo sapiens	39-45
32368288-0	2020	HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.	UNII-QA3Y8EZG57	16-22	spermatogenesis associated 2	Homo sapiens	64-68
35232349-9	2022	In addition, there were significant associations between TMB and IGF2BP family expression profiles, which positively correlated with the expression of PD-1 (p < 0.05).	1,2,4,5-tetramethoxybenzene	57-60	spermatogenesis associated 2	Homo sapiens	151-155
33828254-2	2021	Recent data suggest that ibrutinib may enhance the anti-tumour activity of anti-PD-1 immunotherapy.	ibrutinib	25-34	spermatogenesis associated 2	Homo sapiens	80-84
32733441-0	2020	Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1.	Tryptophan	0-10	spermatogenesis associated 2	Homo sapiens	72-76
31334002-5	2019	Here we demonstrated functional inhibition of G-MDSCs with (S)-(-)-N-[2-(3-Hydroxy-1H-indol-3-yl)-methyl]-acetamide (SNA), a specific inhibitor of PI3Kdelta/gamma, could prime tumor microenvironment, resultantly enhancing the therapeutic efficacy of anti-PD1 treatment in a syngeneic osteosarcoma tumor model.	(s)-(-)-N-[2-(3-hydroxy-1h-indol-3-yl)-methyl]-acetamide	59-115	spermatogenesis associated 2	Homo sapiens	255-258
18634265-10	2008	PD1 patients obtained significantly worse scores than PD2 ones on DAUF (significantly decreased number of correct reactions: p < 0.05 and significantly increased number of incorrect reactions: p < 0.05).	dauf	66-70	spermatogenesis associated 2	Homo sapiens	0-3
29938495-2	2018	We have previously shown that modulating the immune system by impairing programmed cell death protein (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) signaling, both receptors involved in immune tolerance, was capable of producing an animal model of amodiaquine (AQ) IDILI with characteristics very similar to IDILI in humans.	Amodiaquine	266-277	spermatogenesis associated 2	Homo sapiens	103-107
29938495-2	2018	We have previously shown that modulating the immune system by impairing programmed cell death protein (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) signaling, both receptors involved in immune tolerance, was capable of producing an animal model of amodiaquine (AQ) IDILI with characteristics very similar to IDILI in humans.	Amodiaquine	279-281	spermatogenesis associated 2	Homo sapiens	103-107