PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30356025-11	2018	Furthermore, ASCEMS pre-treated with AZA/RES displayed anti-inflammatory properties, as decreased levels of TNF-alpha, nitric oxide (NO), and IL-6 were observed in those cells in comparison with their untreated counterparts in the co-culture with RAW264.7 macrophages.	aza	37-40	interleukin 6	Equus caballus	142-146
29554899-8	2018	Stanozolol treatment reduced gene expression of MMP-13, MMP-1, IL-6 and COX-2 in both normal and IL-1beta treated chondrocytes.	Stanozolol	0-10	interleukin 6	Equus caballus	63-67
28441052-7	2017	Cells treated with HA or HA-CS-NAG had significantly better viability and morphology scores and lower concentrations of PGE2, MMP-3, IL-6, and COX-2 than untreated LPS challenge-exposed cells.	Hyaluronic Acid	19-21	interleukin 6	Equus caballus	133-137
29034249-13	2017	These studies revealed that misoprostol pre- and posttreatment inhibited LPS-induced TNFalpha and IL-6 protein production in equine leukocytes but had no effect on IL-8 protein.	Misoprostol	28-39	interleukin 6	Equus caballus	98-102
29034249-15	2017	At the mRNA level, misoprostol pre- and posttreatment inhibited LPS-induced TNFalpha, IL-1beta, and IL-6 mRNA production but did not affect IL-8 mRNA.	Misoprostol	19-30	interleukin 6	Equus caballus	100-104
28441052-7	2017	Cells treated with HA or HA-CS-NAG had significantly better viability and morphology scores and lower concentrations of PGE2, MMP-3, IL-6, and COX-2 than untreated LPS challenge-exposed cells.	ha-cs	25-30	interleukin 6	Equus caballus	133-137
28441052-7	2017	Cells treated with HA or HA-CS-NAG had significantly better viability and morphology scores and lower concentrations of PGE2, MMP-3, IL-6, and COX-2 than untreated LPS challenge-exposed cells.	Acetylglucosamine	31-34	interleukin 6	Equus caballus	133-137
28441052-9	2017	Cells treated with HA-CS-NAG had significantly superior suppression of LPS-induced production of PGE2, IL-6, and MMP-3 than cells treated with HA alone.	ha-cs	19-24	interleukin 6	Equus caballus	103-107
28441052-9	2017	Cells treated with HA-CS-NAG had significantly superior suppression of LPS-induced production of PGE2, IL-6, and MMP-3 than cells treated with HA alone.	Acetylglucosamine	25-28	interleukin 6	Equus caballus	103-107
28441052-9	2017	Cells treated with HA-CS-NAG had significantly superior suppression of LPS-induced production of PGE2, IL-6, and MMP-3 than cells treated with HA alone.	Hyaluronic Acid	19-21	interleukin 6	Equus caballus	103-107
25333408-1	2014	In this work, we report a simple and novel electrochemical multiplexed immunosensor on a flexible polydimethylsiloxane (PDMS) slice deposited with 8 x 8 nano-Au film electrodes for simultaneous detection of prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and interleukin-6 (IL-6).	baysilon	98-118	interleukin 6	Equus caballus	287-300
25333408-1	2014	In this work, we report a simple and novel electrochemical multiplexed immunosensor on a flexible polydimethylsiloxane (PDMS) slice deposited with 8 x 8 nano-Au film electrodes for simultaneous detection of prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and interleukin-6 (IL-6).	baysilon	98-118	interleukin 6	Equus caballus	302-306
25333408-1	2014	In this work, we report a simple and novel electrochemical multiplexed immunosensor on a flexible polydimethylsiloxane (PDMS) slice deposited with 8 x 8 nano-Au film electrodes for simultaneous detection of prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and interleukin-6 (IL-6).	Gold	158-160	interleukin 6	Equus caballus	287-300
25333408-1	2014	In this work, we report a simple and novel electrochemical multiplexed immunosensor on a flexible polydimethylsiloxane (PDMS) slice deposited with 8 x 8 nano-Au film electrodes for simultaneous detection of prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and interleukin-6 (IL-6).	Gold	158-160	interleukin 6	Equus caballus	302-306
21330167-0	2011	A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio.	Copper	69-75	interleukin 6	Equus caballus	34-47
23946535-2	2013	Additionally, the influence of IL1alpha, IL1beta, and IL6 on prostaglandin (PG) secretion and PG synthase mRNA transcription in endometrial tissue during endometrosis was investigated.	Prostaglandins	61-79	interleukin 6	Equus caballus	54-57
23447881-5	2012	RESULTS: Equine colostral carbohydrates significantly reduced LPS-induced TNF-alpha protein at both times measured and significantly reduced LPS-induced TNF-alpha, IL-6 and IL-10 mRNA expression by PBMCs.	Carbohydrates	26-39	interleukin 6	Equus caballus	164-168
22578853-10	2012	LPS and Poly IC induced respectively significant increases of TNF-alpha, IFN-beta, IL-6, IL-1beta, and TNF-alpha, IFN-beta, IP-10 and RANTES, both before and after exercise.	Poly I-C	8-15	interleukin 6	Equus caballus	83-87
22943507-14	2013	Ethyl pyruvate significantly decreased, but FM significantly increased, IL-6 expression.	ethyl pyruvate	0-14	interleukin 6	Equus caballus	72-76
21496101-13	2012	While A(2B) AR is the predominant proinflammatory AR subtype expressed, A(2A) AR appears to modulate inflammatory signalling (IL-6 expression) by adenosine.	Adenosine	146-155	interleukin 6	Equus caballus	126-130
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Zinc	305-307	interleukin 6	Equus caballus	149-153
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Copper	309-311	interleukin 6	Equus caballus	149-153
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Selenium	313-315	interleukin 6	Equus caballus	149-153
21430601-11	2011	Foals receiving hydrocortisone had significantly decreased endotoxin-induced expression of TNF-alpha, IL-6, IL-8, and IL-1beta.	Hydrocortisone	16-30	interleukin 6	Equus caballus	102-106
21831454-0	2011	Lamellar leukocyte infiltration and involvement of IL-6 during oligofructose-induced equine laminitis development.	oligofructose	63-76	interleukin 6	Equus caballus	51-55
21831454-4	2011	Using real time PCR, immunohistochemistry and zymography methods, we characterize leukocyte infiltration and IL-6 gene expression in oligofructose (OF) induced laminitis.	oligofructose	133-146	interleukin 6	Equus caballus	109-113
21330167-1	2011	The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ~1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe.	Iron	320-322	interleukin 6	Equus caballus	149-153
17975975-7	2007	RESULTS: Laminar concentrations of IL-1beta, IL-6, IL-8, COX-2, ICAM-1, and E-selectin mRNA were significantly increased in ETP horses, compared with control horses.	etp	124-127	interleukin 6	Equus caballus	45-49
19041991-7	2009	The study identifies OCF as a source of inflammatory mediators in equine OA, as shown by the presence of IL-6 and extracellular HMGB-1 in the fragment.	ocf	21-24	interleukin 6	Equus caballus	105-109
21492212-10	2011	There was a significant reduction in TNFalpha, IL-1beta and IL-6 gene expression in endotoxin stimulated whole blood from horses 6 h after receiving 150 mg/kg bwt ethyl pyruvate.	ethyl pyruvate	163-177	interleukin 6	Equus caballus	60-64
15955566-11	2005	All the IFN inducing ODN also induced IL-6 production and the levels of IL-6 induced seemed influenced by addition of lipofectin and presence of poly-G sequences in the same way as was observed for the IFN-production.	1,2-dielaidoylphosphatidylethanolamine	118-128	interleukin 6	Equus caballus	72-76
15955566-11	2005	All the IFN inducing ODN also induced IL-6 production and the levels of IL-6 induced seemed influenced by addition of lipofectin and presence of poly-G sequences in the same way as was observed for the IFN-production.	Poly G	145-151	interleukin 6	Equus caballus	72-76
15955566-12	2005	However, a complete phosphorothioate ODN with a central CpG-motif and poly-C sequences, that did not induce IFN, readily induced IL-6 both in the presence and absence of lipofectin.	Parathion	20-36	interleukin 6	Equus caballus	129-133
15955566-12	2005	However, a complete phosphorothioate ODN with a central CpG-motif and poly-C sequences, that did not induce IFN, readily induced IL-6 both in the presence and absence of lipofectin.	Poly C	70-76	interleukin 6	Equus caballus	129-133
9918150-12	1999	RESULTS: For study 1, prior treatment with PBD completely blocked endotoxin-induced changes for heart and respiratory rates, rectal temperature, WBC count, and plasma tumor necrosis factor, interleukin 6, TXB2, and prostaglandin F1 concentrations.	pbd	43-46	interleukin 6	Equus caballus	190-203
15720977-0	2005	Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line.	Ketamine	0-8	interleukin 6	Equus caballus	63-76
15720977-5	2005	Hence, the objective of this study was to assess the influence of ketamine on LPS-induced TNF-alpha and IL-6 formation in an equine macrophage cell line (eCAS cells).	Ketamine	66-74	interleukin 6	Equus caballus	104-108
12000535-0	2002	Effects of carprofen (R and S enantiomers and racemate) on the production of IL-1, IL-6 and TNF-alpha by equine chondrocytes and synoviocytes.	carprofen	11-20	interleukin 6	Equus caballus	83-87
12000535-4	2002	Both carprofen enantiomers and the racemic mixture attenuated the increase in IL-6 induced by LPS in synoviocytes, and S carprofen exerted a similar effect on chondrocytes.	carprofen	5-14	interleukin 6	Equus caballus	78-82
12000535-6	2002	An action of carprofen to suppress IL-6 release might contribute to the actions which occur in vivo.	carprofen	13-22	interleukin 6	Equus caballus	35-39
9361895-7	1997	Tumor necrosis factor and IL-6 activities in horses given PTX alone were not significantly different from values in those given the saline bolus.	Pentoxifylline	58-61	interleukin 6	Equus caballus	26-30
9361895-10	1997	Horses of the FM and FM/PTX groups had significantly higher IL-6 activity at 1.5 and 2 hours than did horses of the PTX and ENDO groups; those of the FM and FM/PTX groups had significantly lower WBC count than did those of the PTX and ENDO groups.	Pentoxifylline	24-27	interleukin 6	Equus caballus	60-64
9049496-5	1996	Tolfenamic acid and flunixin increased the production of IL-6-like activity by LPS-stimulated synoviocytes only at the highest concentration studied (1000 mumol/l).	tolfenamic acid	0-15	interleukin 6	Equus caballus	57-61
9049496-5	1996	Tolfenamic acid and flunixin increased the production of IL-6-like activity by LPS-stimulated synoviocytes only at the highest concentration studied (1000 mumol/l).	flunixin	20-28	interleukin 6	Equus caballus	57-61
30836143-9	2019	Synoviocyte cultures pre-treated with EPA or DHA followed by reIL-1beta stimulation had significant reductions in expression of ADAMTS4, MMP-1, MMP-13, IL-1beta, IL-6 and COX-2.	Eicosapentaenoic Acid	38-41	interleukin 6	Equus caballus	162-166
7628064-4	1994	Pentoxifylline inhibited endotoxin-induced increases in tumor necrosis factor (TNF) and interleukin-6 (IL-6) activity in a dose-related fashion, whether added before, at the same time, or after endotoxin.	Pentoxifylline	0-14	interleukin 6	Equus caballus	88-101
7628064-4	1994	Pentoxifylline inhibited endotoxin-induced increases in tumor necrosis factor (TNF) and interleukin-6 (IL-6) activity in a dose-related fashion, whether added before, at the same time, or after endotoxin.	Pentoxifylline	0-14	interleukin 6	Equus caballus	103-107
34562796-4	2021	Compared to front or hind limbs at ambient temperature, CDH resulted in significantly lower expression of KRT17, CCL2, CxCL8, PTGS2 (encoding COX2), IL6, TNFalpha, S100A8 and MMP1.	cdh	56-59	interleukin 6	Equus caballus	149-152
33843261-10	2021	AAV transduction itself was associated with decreased synthesis of IL-1beta, IL-6 and TNF-alpha.	CHEMBL2031461	0-3	interleukin 6	Equus caballus	77-81
33153060-7	2020	Silibilinin was able to prevent the LPS induced increased levels of TNF-alpha, IL-1beta, IL-6 and IL-8.	silibilinin	0-11	interleukin 6	Equus caballus	89-93
32622203-11	2020	Dead sperm in saline markedly increased PMNs counts, IL-6 and TNFalpha expression in the ELISA (p < 0.05) and immunostaining.	Sodium Chloride	14-20	interleukin 6	Equus caballus	53-57
32622203-14	2020	In the aMSC-treated group, a significant decrease was found in the expression of (IL1alpha, p = 0.0003; IL-6 p 0.04; IL-8, p = 0.006, TNFalpha p = 0.004).	amsc	7-11	interleukin 6	Equus caballus	104-110
32365982-8	2020	Furthermore, the 10% DMSO group had lower concentrations of PGE2 and IL-1beta at T48 than at T8 (p<0.05) and presented lower IL-6 levels than the5% DMSO and lactated Ringer"s groups at T24.	Dimethyl Sulfoxide	21-25	interleukin 6	Equus caballus	125-129
30836143-9	2019	Synoviocyte cultures pre-treated with EPA or DHA followed by reIL-1beta stimulation had significant reductions in expression of ADAMTS4, MMP-1, MMP-13, IL-1beta, IL-6 and COX-2.	Docosahexaenoic Acids	45-48	interleukin 6	Equus caballus	162-166
30836143-9	2019	Synoviocyte cultures pre-treated with EPA or DHA followed by reIL-1beta stimulation had significant reductions in expression of ADAMTS4, MMP-1, MMP-13, IL-1beta, IL-6 and COX-2.	reil-1beta	61-71	interleukin 6	Equus caballus	162-166