PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32457396-7	2020	Mechanistically, the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion, and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.	Sirolimus	126-135	musashi RNA-binding protein 1	Mus musculus	186-190
33741693-7	2021	Engineered mouse models treated with the therapeutic agent 5-fluorouracil showed that upon increased MSI1 levels, Lgr5high-SCs remain sensitive while Lgr5low-progenitors reprogram to a drug-resistant phenotype.	Fluorouracil	59-73	musashi RNA-binding protein 1	Mus musculus	101-105
33177876-0	2020	Down-Regulation of Circ_0032833 Sensitizes Colorectal Cancer to 5-Fluorouracil and Oxaliplatin Partly Depending on the Regulation of miR-125-5p and MSI1.	Fluorouracil	64-78	musashi RNA-binding protein 1	Mus musculus	148-152
33177876-0	2020	Down-Regulation of Circ_0032833 Sensitizes Colorectal Cancer to 5-Fluorouracil and Oxaliplatin Partly Depending on the Regulation of miR-125-5p and MSI1.	Oxaliplatin	83-94	musashi RNA-binding protein 1	Mus musculus	148-152
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	mir-125-5p	9-19	musashi RNA-binding protein 1	Mus musculus	29-37
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	mir-125-5p	9-19	musashi RNA-binding protein 1	Mus musculus	39-43
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	Fluorouracil	79-93	musashi RNA-binding protein 1	Mus musculus	29-37
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	Fluorouracil	79-93	musashi RNA-binding protein 1	Mus musculus	39-43
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	Oxaliplatin	98-109	musashi RNA-binding protein 1	Mus musculus	29-37
33177876-11	2020	Besides, miR-125-5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells.	Oxaliplatin	98-109	musashi RNA-binding protein 1	Mus musculus	39-43
33177876-12	2020	We found that circ_0032833 generated the regulation on MSI1 by sponging miR-125-5p.	mir-125-5p	72-82	musashi RNA-binding protein 1	Mus musculus	55-59
33177876-13	2020	Circ_0032833 down-regulation also promoted the 5-fluorouracil and oxaliplatin sensitivities partly through the miR-125-5p/MSI1 axis in vivo.	Fluorouracil	47-61	musashi RNA-binding protein 1	Mus musculus	122-126
33177876-13	2020	Circ_0032833 down-regulation also promoted the 5-fluorouracil and oxaliplatin sensitivities partly through the miR-125-5p/MSI1 axis in vivo.	Oxaliplatin	66-77	musashi RNA-binding protein 1	Mus musculus	122-126
33177876-14	2020	Conclusion: This study illuminated an unambiguous mechanism circ_0032833/miR-125-5p/MSI1 on regulating 5-fluorouracil and oxaliplatin sensitivities in FOLFOX therapy, maybe providing a deep insight of resistance formation and developing a novel strategy to enhance chemosensitivity in CRC.	Fluorouracil	103-117	musashi RNA-binding protein 1	Mus musculus	84-88
33177876-14	2020	Conclusion: This study illuminated an unambiguous mechanism circ_0032833/miR-125-5p/MSI1 on regulating 5-fluorouracil and oxaliplatin sensitivities in FOLFOX therapy, maybe providing a deep insight of resistance formation and developing a novel strategy to enhance chemosensitivity in CRC.	Oxaliplatin	122-133	musashi RNA-binding protein 1	Mus musculus	84-88
30942388-0	2019	Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	musashi RNA-binding protein 1	Mus musculus	0-9
31938070-7	2020	MSI-1 exerted rapid bactericidal activity and effectively improved the survival rate and wound closure in penicillin-resistant E. coli-infected mice by eliminating bacterial counts in mouse organs or subeschar, further inhibiting the systemic dissemination of bacteria.	Penicillins	106-116	musashi RNA-binding protein 1	Mus musculus	0-5
31938070-8	2020	Additionally, MSI-1 displayed perfect stability against violent pH, temperature variations and high NaCl concentrations and has the ability to circumvent the development of drug resistance.	Sodium Chloride	100-104	musashi RNA-binding protein 1	Mus musculus	14-19
32504765-8	2020	Collectively, MSI-1 possessed potent anti-cryptococcal activity via its notable membrane disruption effect and may be a potential candidate for use in antifungal infection induced by C. neoformans, especially azole-resistant cryptococcus.	Azoles	209-214	musashi RNA-binding protein 1	Mus musculus	14-19
31759926-11	2020	Acetate, a precursor of acetyl-CoA (a product of fatty acid beta-oxidation [FAO]), or dichloroacetate, a compound that promotes pyruvate oxidation and generation of mitochondrial acetyl-CoA, were used for metabolic intervention RESULTS: Crypt cells rapidly absorbed labeled fatty acid, and mRNA levels of Lgr5+ stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were downregulated in organoids incubated with etomoxir, an inhibitor of FAO, indicating that FAO was required for renewal of ISCs.	Acetates	0-7	musashi RNA-binding protein 1	Mus musculus	350-354
31759926-11	2020	Acetate, a precursor of acetyl-CoA (a product of fatty acid beta-oxidation [FAO]), or dichloroacetate, a compound that promotes pyruvate oxidation and generation of mitochondrial acetyl-CoA, were used for metabolic intervention RESULTS: Crypt cells rapidly absorbed labeled fatty acid, and mRNA levels of Lgr5+ stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were downregulated in organoids incubated with etomoxir, an inhibitor of FAO, indicating that FAO was required for renewal of ISCs.	Dichloroacetic Acid	86-101	musashi RNA-binding protein 1	Mus musculus	350-354
30942388-4	2019	A pMsi1-green fluorescence protein reporter plasmid was used to sort the Msi1-positive cells from mESCs treated and untreated with LY294002 (5 micromol/l).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	131-139	musashi RNA-binding protein 1	Mus musculus	3-7
30942388-7	2019	Compared with the Msi1-positive cells derived from mESCs without LY294002 treatment, Msi1-positive cells derived from mESCs treated with LY294002 expressed higher levels of leucine-rich repeat-containing G-protein coupled receptor, a marker of intestinal epithelial stem cells, and lower levels of Nestin, a marker of neural epithelial stem cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	musashi RNA-binding protein 1	Mus musculus	85-89
30942388-8	2019	The grafts from Msi1-positive cells treated with LY294002 contained more intestinal epithelial-like tissues and fewer neural epithelial-like tissues, compared with those from untreated Msi1-positive cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	49-57	musashi RNA-binding protein 1	Mus musculus	16-20
30942388-10	2019	The Msi1-positive cells selected from the cell population derived from mESCs treated with LY294002 exhibited more characteristics of intestinal epithelial stem cells than those from the untreated group.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	90-98	musashi RNA-binding protein 1	Mus musculus	4-8
27129280-8	2016	Oleic acid is a known inhibitor of Msi1 and injecting oleic acid followed by unilateral ureteral obstruction surgery in mice resulted in enhanced fibrosis compared with the control group, indicating that inhibiting Msi1 activity renders the mice more susceptible to fibrosis.	Oleic Acid	0-10	musashi RNA-binding protein 1	Mus musculus	35-39
30097032-6	2018	We validated Gn binding to MSI1 using surface plasmon resonance, nuclear magnetic resonance, and cellular thermal shift assay, and tested the effects of Gn on colon cancer cells and colon cancer DLD-1 xenografts in nude mice.	gossypolone	13-15	musashi RNA-binding protein 1	Mus musculus	27-31
28554763-7	2017	After treatment of 5-FU, the intestinal mucous were damaged, although the number of msi-1 positive cells has a little decrease, there was no statistical difference among the mice at different time after injection (P>0.05).	Fluorouracil	19-23	musashi RNA-binding protein 1	Mus musculus	84-89
28554763-9	2017	There was significant positive correction between the percentage of msi-1 positive cells and the percentage of Rho low staining cell fraction (r=0.867, p<0.01) after 5-FU injection.	Fluorouracil	169-173	musashi RNA-binding protein 1	Mus musculus	68-73
27129280-8	2016	Oleic acid is a known inhibitor of Msi1 and injecting oleic acid followed by unilateral ureteral obstruction surgery in mice resulted in enhanced fibrosis compared with the control group, indicating that inhibiting Msi1 activity renders the mice more susceptible to fibrosis.	Oleic Acid	0-10	musashi RNA-binding protein 1	Mus musculus	215-219
27129280-8	2016	Oleic acid is a known inhibitor of Msi1 and injecting oleic acid followed by unilateral ureteral obstruction surgery in mice resulted in enhanced fibrosis compared with the control group, indicating that inhibiting Msi1 activity renders the mice more susceptible to fibrosis.	Oleic Acid	54-64	musashi RNA-binding protein 1	Mus musculus	215-219
27129280-9	2016	Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis.	Fatty Acids	23-33	musashi RNA-binding protein 1	Mus musculus	150-154
27129280-9	2016	Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis.	Fatty Acids	135-145	musashi RNA-binding protein 1	Mus musculus	150-154
25933687-0	2015	Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.	Gossypol	16-28	musashi RNA-binding protein 1	Mus musculus	96-105
25933687-10	2015	Our study identifies (-)-gossypol as a potential small molecule inhibitor of MSI1-RNA interaction, and suggests that inhibition of MSI1"s RNA binding activity may be an effective anti-cancer strategy.	Gossypol	21-33	musashi RNA-binding protein 1	Mus musculus	77-81
25933687-10	2015	Our study identifies (-)-gossypol as a potential small molecule inhibitor of MSI1-RNA interaction, and suggests that inhibition of MSI1"s RNA binding activity may be an effective anti-cancer strategy.	Gossypol	21-33	musashi RNA-binding protein 1	Mus musculus	131-135
25933687-7	2015	Surface plasmon resonance and nuclear magnetic resonance studies demonstrate a direct interaction of (-)-gossypol with the RNA binding pocket of MSI1.	Gossypol	101-113	musashi RNA-binding protein 1	Mus musculus	145-149
25933687-8	2015	We further showed that (-)-gossypol reduces Notch/Wnt signaling in several colon cancer cell lines having high levels of MSI1, with reduced SURVIVIN expression and increased apoptosis/autophagy.	Gossypol	23-35	musashi RNA-binding protein 1	Mus musculus	121-125
23894503-8	2013	RESULTS: Ethanol decreased NSC mRNAs for c-kit, Musashi-1and GFAP.	Ethanol	9-16	musashi RNA-binding protein 1	Mus musculus	48-57
25185661-10	2015	pSmad2/3L-Thr immunostaining-strongly positive cells showed co-localization with cytokeratin 8, CDK4, and Musashi-1 and different localization from chromogranin A and DCAMKL1 immunostaining-positive cells.	Threonine	10-13	musashi RNA-binding protein 1	Mus musculus	106-115
22026428-3	2011	This study was to explore whether sorting SP could enrich for the Musashi1 (Msi1) positive cells from Msi1 high expression cells (Msi1(high) cells) derived from mouse embryonic stem cells (ESCs) in vitro.	sp	42-44	musashi RNA-binding protein 1	Mus musculus	66-74
22687993-8	2012	Among the genes related to Sertoli cells, downregulation of Msi1h, Ncoa1, Nid1, Hspb2, and Gata6 were detected in the testis of mice treated with BPA (twice administered 50 mg/kg).	bisphenol A	146-149	musashi RNA-binding protein 1	Mus musculus	60-65
23308249-0	2013	Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa.	Phosphotyrosine	42-57	musashi RNA-binding protein 1	Mus musculus	0-9
23308249-1	2013	OBJECTIVE: Upregulation of the RNA-binding protein Musashi-1 (Msi1) has been shown to occur in rat gastric corpus mucosa after ethanol-induced mucosal injury.	Ethanol	127-134	musashi RNA-binding protein 1	Mus musculus	51-60
23308249-4	2013	METHODS: Acute gastric injury was induced in Msi1-KO and wild-type ICR mice by administering absolute ethanol.	Ethanol	102-109	musashi RNA-binding protein 1	Mus musculus	45-49
22645129-6	2012	Furthermore, by knocking down a fucosyltransferase 9 with short interfering RNA, we demonstrated that the Lewis X-carrying N-glycans were actively involved in the proliferation of NSCs via modulation of the expression level of Musashi-1, which is an activator of the Notch signaling pathway.	n-glycans	123-132	musashi RNA-binding protein 1	Mus musculus	227-236
22026428-3	2011	This study was to explore whether sorting SP could enrich for the Musashi1 (Msi1) positive cells from Msi1 high expression cells (Msi1(high) cells) derived from mouse embryonic stem cells (ESCs) in vitro.	sp	42-44	musashi RNA-binding protein 1	Mus musculus	76-80
22026428-3	2011	This study was to explore whether sorting SP could enrich for the Musashi1 (Msi1) positive cells from Msi1 high expression cells (Msi1(high) cells) derived from mouse embryonic stem cells (ESCs) in vitro.	sp	42-44	musashi RNA-binding protein 1	Mus musculus	102-106
22026428-3	2011	This study was to explore whether sorting SP could enrich for the Musashi1 (Msi1) positive cells from Msi1 high expression cells (Msi1(high) cells) derived from mouse embryonic stem cells (ESCs) in vitro.	sp	42-44	musashi RNA-binding protein 1	Mus musculus	102-106
22026428-8	2011	SP fraction was identified and isolated from Msi1(high) cell population.	sp	0-2	musashi RNA-binding protein 1	Mus musculus	45-49
22026428-9	2011	The expression of Msi1 in SP fraction was significantly higher than that in NSP fraction and unsorted Msi1(high) cells (P< 0.05).	sp	26-28	musashi RNA-binding protein 1	Mus musculus	18-22
22026428-11	2011	CONCLUSIONS: SP fraction, isolated from Msi1(high) cells, contains almost all the Msi1-positive cells and has the potential to differentiate into neural and intestinal epithelial cells in vivo.	sp	13-15	musashi RNA-binding protein 1	Mus musculus	40-44
22026428-11	2011	CONCLUSIONS: SP fraction, isolated from Msi1(high) cells, contains almost all the Msi1-positive cells and has the potential to differentiate into neural and intestinal epithelial cells in vivo.	sp	13-15	musashi RNA-binding protein 1	Mus musculus	82-86
22026428-12	2011	Sorting SP fraction could be a convenient and practical method to enrich for Msi1-positive cells from the differentiated cell population derived from ESCs.	sp	8-10	musashi RNA-binding protein 1	Mus musculus	77-81
21486496-9	2011	Fluorescence and Luciferase activity, reflecting the Msi1 transcriptional activity, were observed in a stable BAC-carrying embryonic stem cell line when it was induced toward neural lineage differentiation by retinoic acid treatment.	Tretinoin	209-222	musashi RNA-binding protein 1	Mus musculus	53-57
21227626-7	2011	The results showed that low-molecular-weight heparin oral colon-specific delivery capsule significantly decreased the serum levels of TNF-alpha, IL-6 as well as FXa, while increased the expression of Musashi-1 in colon compared with acetic acid-induced ulcerative colitis model group.	Heparin	45-52	musashi RNA-binding protein 1	Mus musculus	200-209
16944023-0	2006	Investigation of Musashi-1 expressing cells in the murine model of dextran sodium sulfate-induced colitis.	dextran sodium sulfate	67-89	musashi RNA-binding protein 1	Mus musculus	17-26
20359854-5	2010	The results showed that LMWH rectal suppository significantly decreased serum levels of TNF-alpha, IL-6 as well as FXa, while increased the expression of Musashi-1 in colon compared with acetic acid induced ulcerative colitis model group.	Heparin, Low-Molecular-Weight	24-28	musashi RNA-binding protein 1	Mus musculus	154-163
19031139-10	2008	There was positive correlation between the percentage of Rhodamine 123 low staining cells and positive msi-1 cells in each group (r=0.867, P<0.01).	Rhodamines	57-66	musashi RNA-binding protein 1	Mus musculus	103-108
19031139-12	2008	The intestinal epithelial stem cells expressing msi-1 can regenerate the damage of intestinal mucosa induced by 5-FU.	Fluorouracil	112-116	musashi RNA-binding protein 1	Mus musculus	48-53
18270838-0	2008	The expression of Msi-1 and its significance in small intestinal mucosa severely damaged by high-dose 5-FU.	Fluorouracil	102-106	musashi RNA-binding protein 1	Mus musculus	18-23
18270838-1	2008	OBJECTIVE: The purpose was to investigate the expression of musashi-1 (msi-1) and its significances in small intestinal mucosa that was severely damaged by high-dose 5-FU.	Fluorouracil	166-170	musashi RNA-binding protein 1	Mus musculus	60-69
18270838-1	2008	OBJECTIVE: The purpose was to investigate the expression of musashi-1 (msi-1) and its significances in small intestinal mucosa that was severely damaged by high-dose 5-FU.	Fluorouracil	166-170	musashi RNA-binding protein 1	Mus musculus	71-76
18270838-5	2008	RESULTS: After treatment with high-dose 5-FU, the intestinal mucosa suffered severe damage: the villi and crypts disappeared, the number of msi-1-positive cells increased greatly, the intestinal epithelial cells could be divided into two fractions by FACS, and the percentage of msi-1-positive cells was up to 67.75% in the fraction in which the value of FSC was higher.	Fluorouracil	40-44	musashi RNA-binding protein 1	Mus musculus	140-145
18270838-5	2008	RESULTS: After treatment with high-dose 5-FU, the intestinal mucosa suffered severe damage: the villi and crypts disappeared, the number of msi-1-positive cells increased greatly, the intestinal epithelial cells could be divided into two fractions by FACS, and the percentage of msi-1-positive cells was up to 67.75% in the fraction in which the value of FSC was higher.	Fluorouracil	40-44	musashi RNA-binding protein 1	Mus musculus	279-284
16944023-3	2006	To clarify the behavior of those cells in the injury or regeneration phase, we investigated Msi-1 expressing cells of intestinal mucosa in the murine model of dextran sodium sulfate (DSS)-induced colitis.	dextran sodium sulfate	159-181	musashi RNA-binding protein 1	Mus musculus	92-97
16944023-3	2006	To clarify the behavior of those cells in the injury or regeneration phase, we investigated Msi-1 expressing cells of intestinal mucosa in the murine model of dextran sodium sulfate (DSS)-induced colitis.	dss	183-186	musashi RNA-binding protein 1	Mus musculus	92-97
16944023-6	2006	In contrast, the number of Msi-1-positive cells decreased slightly with DSS but returned to normal after DSS administration was stopped.	dss	72-75	musashi RNA-binding protein 1	Mus musculus	27-32
16944023-6	2006	In contrast, the number of Msi-1-positive cells decreased slightly with DSS but returned to normal after DSS administration was stopped.	dss	105-108	musashi RNA-binding protein 1	Mus musculus	27-32
12093154-6	2002	T3 increases msi-1 mRNA level in an actinomycin D-sensitive, cycloheximide-resistant fashion without affecting its half-life, which suggests a transcriptional effect.	Dactinomycin	36-49	musashi RNA-binding protein 1	Mus musculus	13-18
12093154-6	2002	T3 increases msi-1 mRNA level in an actinomycin D-sensitive, cycloheximide-resistant fashion without affecting its half-life, which suggests a transcriptional effect.	Cycloheximide	61-74	musashi RNA-binding protein 1	Mus musculus	13-18
12093154-8	2002	Furthermore, antisense msi-1 expression inhibited T3 action.	Triiodothyronine	50-52	musashi RNA-binding protein 1	Mus musculus	23-28
9047340-3	1997	In this study, we found that the N-terminal RRM of m-Msi-1 (MMA) binds strongly to poly(G) and weakly to poly(U) in a way similar to that of the full-length m-Msi-1 protein characterized previously.	mma	60-63	musashi RNA-binding protein 1	Mus musculus	51-58
9047340-3	1997	In this study, we found that the N-terminal RRM of m-Msi-1 (MMA) binds strongly to poly(G) and weakly to poly(U) in a way similar to that of the full-length m-Msi-1 protein characterized previously.	poly	83-87	musashi RNA-binding protein 1	Mus musculus	51-58
9047340-3	1997	In this study, we found that the N-terminal RRM of m-Msi-1 (MMA) binds strongly to poly(G) and weakly to poly(U) in a way similar to that of the full-length m-Msi-1 protein characterized previously.	poly	105-109	musashi RNA-binding protein 1	Mus musculus	51-58