PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34008284-11	2021	An epigenetic reprograming of IGF2R and KCNQ1OT1 ncRNA in the offspring was evident upon different dietary combinations of folic acid and B12 in the mice.	zwittergent 3-12	138-141	KCNQ1 overlapping transcript 1	Mus musculus	40-48
34008284-0	2021	Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.	Folic Acid	34-44	KCNQ1 overlapping transcript 1	Mus musculus	127-135
33293505-6	2020	Accordingly, kcnq1ot1 overexpression inhibited cholesterol efflux and promoted lipid accumulation in THP-1 macrophages.	Cholesterol	47-58	KCNQ1 overlapping transcript 1	Mus musculus	13-21
34008284-0	2021	Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.	Vitamin B 12	49-60	KCNQ1 overlapping transcript 1	Mus musculus	127-135
34008284-8	2021	Over-supplementation of either folate or B12 or both vitamins in comparison to BNFN, led to increase in expression of IGF2R and KCNQ1OT1 in the placenta and fetal tissues.	Folic Acid	31-37	KCNQ1 overlapping transcript 1	Mus musculus	128-136
34008284-8	2021	Over-supplementation of either folate or B12 or both vitamins in comparison to BNFN, led to increase in expression of IGF2R and KCNQ1OT1 in the placenta and fetal tissues.	zwittergent 3-12	41-44	KCNQ1 overlapping transcript 1	Mus musculus	128-136
34008284-10	2021	KCNQ1OT1 noncoding RNA (ncRNA), however, showed upregulation under deficient conditions of folate and B12 only in female fetal tissues which correlated well with hypomethylation observed under these conditions.	Folic Acid	91-97	KCNQ1 overlapping transcript 1	Mus musculus	0-8
34008284-10	2021	KCNQ1OT1 noncoding RNA (ncRNA), however, showed upregulation under deficient conditions of folate and B12 only in female fetal tissues which correlated well with hypomethylation observed under these conditions.	zwittergent 3-12	102-105	KCNQ1 overlapping transcript 1	Mus musculus	0-8
34008284-11	2021	An epigenetic reprograming of IGF2R and KCNQ1OT1 ncRNA in the offspring was evident upon different dietary combinations of folic acid and B12 in the mice.	Folic Acid	123-133	KCNQ1 overlapping transcript 1	Mus musculus	40-48
33293505-8	2020	Mechanistically, kcnq1ot1 enhanced HDAC3 expression by competitively binding to miR-452-3p, thereby inhibiting ABCA1 expression and subsequent cholesterol efflux.	mir-452-3p	80-90	KCNQ1 overlapping transcript 1	Mus musculus	17-25
33293505-8	2020	Mechanistically, kcnq1ot1 enhanced HDAC3 expression by competitively binding to miR-452-3p, thereby inhibiting ABCA1 expression and subsequent cholesterol efflux.	Cholesterol	143-154	KCNQ1 overlapping transcript 1	Mus musculus	17-25
32912499-0	2020	Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose-Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis.	Oxygen	34-40	KCNQ1 overlapping transcript 1	Mus musculus	16-24
32779042-0	2020	LncRNA KCNQ1OT1 ameliorates the liver injury induced by acetaminophen through the regulation of miR-122-5p/CES2 axis.	Acetaminophen	56-69	KCNQ1 overlapping transcript 1	Mus musculus	7-15
32912499-0	2020	Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose-Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis.	Glucose	41-48	KCNQ1 overlapping transcript 1	Mus musculus	16-24
29252185-3	2018	KCNQ1OT1 and IL-10 expression were both suppressed and miR-21a-5p expression was promoted in PMMA-induced cells.	Polymethyl Methacrylate	93-97	KCNQ1 overlapping transcript 1	Mus musculus	0-8
32897512-8	2022	Furthermore, the knockdown of KCNQ1OT1 augmented the TMZ-induced tumor regression in TMZ-resistant U251 mouse models.	Temozolomide	53-56	KCNQ1 overlapping transcript 1	Mus musculus	30-38
32897512-8	2022	Furthermore, the knockdown of KCNQ1OT1 augmented the TMZ-induced tumor regression in TMZ-resistant U251 mouse models.	Temozolomide	85-88	KCNQ1 overlapping transcript 1	Mus musculus	30-38
32897512-9	2022	Briefly, the present study evaluated that KCNQ1OT1 conferred TMZ resistance by releasing PIM1 expression from miR-761, resulting in the upregulation of PIM-mediated MDR1, c-Myc, and Survivin.	Temozolomide	61-64	KCNQ1 overlapping transcript 1	Mus musculus	42-50
33145050-11	2020	KCNQ1OT1 has been shown to compete competitively with miR-2054 and has a negative correlation with its expression.	mir-2054	54-62	KCNQ1 overlapping transcript 1	Mus musculus	0-8
33145050-12	2020	The combination of miR-2054 can reverse the effect of the KCNQ1OT1 combination in Ang-II-induced cardiomyocytes.	mir-2054	19-27	KCNQ1 overlapping transcript 1	Mus musculus	58-66
32142542-8	2020	Targeted bisulfite sequencing was utilized to examine imprinted methylation at the Kcnq1ot1 imprinting control region, with significant hypermethylation observed upon natural paternal aging.	hydrogen sulfite	9-18	KCNQ1 overlapping transcript 1	Mus musculus	83-91
31849486-11	2019	MiR-204-5p was inversely correlated with KCNQ1OT1 or ATG3.	A 204	0-10	KCNQ1 overlapping transcript 1	Mus musculus	41-49
30945454-4	2019	In this study, we revealed that potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1) was significantly upregulated in ischemic stroke.	Potassium	32-41	KCNQ1 overlapping transcript 1	Mus musculus	104-112
32146419-6	2020	Overexpressing KCNQ1OT1 suppressed PDFG-BB-induced VSMC proliferation, migration, and secretion of inflammatory factors.	pdfg	35-39	KCNQ1 overlapping transcript 1	Mus musculus	15-23
32146419-6	2020	Overexpressing KCNQ1OT1 suppressed PDFG-BB-induced VSMC proliferation, migration, and secretion of inflammatory factors.	boeravinone B	40-42	KCNQ1 overlapping transcript 1	Mus musculus	15-23
31625414-3	2019	Here, we hypothesized that lncRNA potassium voltage-gated channel subfamily q member 1 overlapping transcript 1 (KCNQ1OT1) could affect the development of MI via regulation of Runt-related transcription factor (RUNX)3 by methylation.	Potassium	34-43	KCNQ1 overlapping transcript 1	Mus musculus	113-121
30250027-5	2018	However, whether Kcnq1ot1 is capable of regulating pyroptosis and fibrosis in high glucose-treated cardiac fibroblasts remains unknown.	Glucose	83-90	KCNQ1 overlapping transcript 1	Mus musculus	17-25
30250027-6	2018	The aim of the study was to investigate the mechanisms of Kcnq1ot1 in DCM.	dcm	70-73	KCNQ1 overlapping transcript 1	Mus musculus	58-66
30250027-8	2018	In vitro, experiments revealed that Kcnq1ot1 and pyroptosis were activated in cardiac fibroblasts treated with 30 mmol/l glucose.	Glucose	121-128	KCNQ1 overlapping transcript 1	Mus musculus	36-44
30250027-11	2018	In addition, silencing Kcnq1ot1 promoted gasdermin D cleavage and the secretion of IL-1beta, thus repressing the TGF-beta1/smads pathway in high glucose-treated cardiac fibroblasts through miR-214-3p and caspase-1.	Glucose	145-152	KCNQ1 overlapping transcript 1	Mus musculus	23-31
29252185-4	2018	Overexpression of KCNQ1OT1 reversed the effect of PMMA on RAW264.7 cells, such as the reduced TNF-alpha concentration and iNOS expression, and increased IL-10 concentration and Arg1 expression in PMMA-induced cell transfected with pcDNA-KCNQ1OT1.	Polymethyl Methacrylate	50-54	KCNQ1 overlapping transcript 1	Mus musculus	18-26
29252185-4	2018	Overexpression of KCNQ1OT1 reversed the effect of PMMA on RAW264.7 cells, such as the reduced TNF-alpha concentration and iNOS expression, and increased IL-10 concentration and Arg1 expression in PMMA-induced cell transfected with pcDNA-KCNQ1OT1.	Polymethyl Methacrylate	50-54	KCNQ1 overlapping transcript 1	Mus musculus	237-245
29252185-4	2018	Overexpression of KCNQ1OT1 reversed the effect of PMMA on RAW264.7 cells, such as the reduced TNF-alpha concentration and iNOS expression, and increased IL-10 concentration and Arg1 expression in PMMA-induced cell transfected with pcDNA-KCNQ1OT1.	Polymethyl Methacrylate	196-200	KCNQ1 overlapping transcript 1	Mus musculus	18-26
29252185-4	2018	Overexpression of KCNQ1OT1 reversed the effect of PMMA on RAW264.7 cells, such as the reduced TNF-alpha concentration and iNOS expression, and increased IL-10 concentration and Arg1 expression in PMMA-induced cell transfected with pcDNA-KCNQ1OT1.	Polymethyl Methacrylate	196-200	KCNQ1 overlapping transcript 1	Mus musculus	237-245
29541443-10	2018	Further study demonstrated that RSV exerted its effect on osteoblastic differentiation by regulating KCNQ1OT1.	Resveratrol	32-35	KCNQ1 overlapping transcript 1	Mus musculus	101-109
29541443-12	2018	Conclusion: RSV accelerated osteoblast differentiation by regulating lncRNA KCNQ1OT1 via Wnt/beta-catenin pathway activation, indicating the functional role of RSV in modulating osteogenesis.	Resveratrol	12-15	KCNQ1 overlapping transcript 1	Mus musculus	76-84
29541443-12	2018	Conclusion: RSV accelerated osteoblast differentiation by regulating lncRNA KCNQ1OT1 via Wnt/beta-catenin pathway activation, indicating the functional role of RSV in modulating osteogenesis.	Resveratrol	160-163	KCNQ1 overlapping transcript 1	Mus musculus	76-84
35587369-9	2022	Finally, we found that the inhibition of osteoclast differentiation by KCNQ1OT1 overexpression could be rescued using a miR-128-3p mimic, while the enhancement of migration and osteoclast differentiation by si-NFAT5 could be reversed with a miR-128-3p inhibitor.	mir-128-3p	120-130	KCNQ1 overlapping transcript 1	Mus musculus	71-79
29339628-0	2018	Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome.	Arsenic Trioxide	74-90	KCNQ1 overlapping transcript 1	Mus musculus	38-46
29339628-12	2018	CONCLUSIONS: To our knowledge, this report is the first to demonstrate that lncRNA Kcnq1ot1 downregulation is responsible for QT interval prolongation induced by ATO at least partially by repressing Kcnq1 expression.	Arsenic Trioxide	162-165	KCNQ1 overlapping transcript 1	Mus musculus	83-91
22569273-3	2012	Of the differentially methylated regions (DMRs) of H19, CpG island 3 was found to have higher DNA methylation levels in IVM group compared with the control group; in contrast, Kcnq1ot1 showed a significant reduction in DNA methylation in IVM mice by using the bisulfite sequence PCR and pyrosequencing.	hydrogen sulfite	260-269	KCNQ1 overlapping transcript 1	Mus musculus	176-184
34089766-15	2021	In vivo, KCNQ1OT1 promoted cardiomyocytes apoptosis via miR-26a-5p/ATG12 pathway.	mir-26a-5p	56-66	KCNQ1 overlapping transcript 1	Mus musculus	9-17
35587369-2	2022	We investigated whether and how potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1), a long noncoding RNA, regulates osteoclast differentiation.	Potassium	32-41	KCNQ1 overlapping transcript 1	Mus musculus	111-119
30355944-16	2018	Furthermore, silencing Kcnq1ot1 reduced cell death, cytoskeletal structure abnormalities and calcium overload in vitro and improved cardiac function and morphology in vivo.	Calcium	93-100	KCNQ1 overlapping transcript 1	Mus musculus	23-31
16611239-5	2006	Here, we analyzed the methylation of DMR for each eight imprinted genes (Igf2r, Lit1, Zac1, Snrpn, Peg1/Mest, Impact, Meg1/Grb10, and H19) by bisulfite sequencing methylation assay, using oocytes from 10 dpp (days post partum), 15 dpp, 20 dpp, and adult mice.	hydrogen sulfite	142-151	KCNQ1 overlapping transcript 1	Mus musculus	80-84
15459184-6	2004	The loss of antisense transcription from the Kcnq1ot1 promoter coincides with an enrichment in the levels of deacetylation and methylation at the lysine 9 residue of histone H3 and DNA methylation at the CpG residues, implying a crucial role for the NF-Y transcription factor in organizing the parent of origin-specific chromatin conformation in the Kcnq1 ICR.	Lysine	146-152	KCNQ1 overlapping transcript 1	Mus musculus	45-53
34521445-10	2021	In addition, overexpression of KCNQ1OT1/XIST partly abolished the inhibitory effects of XBP-1u knockdown or tunicamycin, an activator of endoplasmic reticulum stress, on CRC cell viability loss and apoptosis.	Tunicamycin	108-119	KCNQ1 overlapping transcript 1	Mus musculus	31-39
35587369-9	2022	Finally, we found that the inhibition of osteoclast differentiation by KCNQ1OT1 overexpression could be rescued using a miR-128-3p mimic, while the enhancement of migration and osteoclast differentiation by si-NFAT5 could be reversed with a miR-128-3p inhibitor.	mir-128-3p	241-251	KCNQ1 overlapping transcript 1	Mus musculus	71-79
35587369-10	2022	These results suggested that KCNQ1OT1 regulates the osteoclast differentiation via the miR-128-3p/NFAT5 axis.	mir-128	87-94	KCNQ1 overlapping transcript 1	Mus musculus	29-37
35108116-5	2022	This study aimed to determine if loss of miR-378a in a genetic mouse model could ameliorate cardiac dysfunction in type 2 diabetes mellitus (T2DM), and to ascertain whether Kcnq1ot1 interacts with miR-378a to impact ATP synthase functionality by preserving mt-ATP6 levels.	Adenosine Triphosphate	216-219	KCNQ1 overlapping transcript 1	Mus musculus	173-181
35108116-9	2022	Together, these data suggest that Kcnq1ot1 and miR-378a may act as constituents in an axis that regulates mt-ATP6 content, and that manipulation of this axis may provide benefit to ATP synthase functionality in the type 2 diabetic heart.	Adenosine Triphosphate	181-184	KCNQ1 overlapping transcript 1	Mus musculus	34-42