PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23926102-5	2013	Although Sp and Gh in quadruplex DNA were good substrates for mNeil3 and NEIL1, none of the glycosylases had activity on quadruplex DNA containing 8-oxoG.	spiroiminodihydantoin	9-11	nei like DNA glycosylase 1	Homo sapiens	73-78
24349107-7	2013	Among the top hits of these screens were several purine analogs, whose postulated presence in the active site of NEIL1 was consistent with the paradigm of NEIL1 recognition and excision of damaged purines.	purine	49-55	nei like DNA glycosylase 1	Homo sapiens	113-118
24349107-7	2013	Among the top hits of these screens were several purine analogs, whose postulated presence in the active site of NEIL1 was consistent with the paradigm of NEIL1 recognition and excision of damaged purines.	purine	49-55	nei like DNA glycosylase 1	Homo sapiens	155-160
24349107-7	2013	Among the top hits of these screens were several purine analogs, whose postulated presence in the active site of NEIL1 was consistent with the paradigm of NEIL1 recognition and excision of damaged purines.	Purines	197-204	nei like DNA glycosylase 1	Homo sapiens	113-118
24349107-7	2013	Among the top hits of these screens were several purine analogs, whose postulated presence in the active site of NEIL1 was consistent with the paradigm of NEIL1 recognition and excision of damaged purines.	Purines	197-204	nei like DNA glycosylase 1	Homo sapiens	155-160
23930966-8	2013	In contrast, the human BER glycosylase NEIL1 exhibited robust activity for all Sp-amine adducts irrespective of size.	sp-amine	79-87	nei like DNA glycosylase 1	Homo sapiens	39-44
23926102-4	2013	We have tested the base excision activities of five mammalian DNA glycosylases (NEIL1, NEIL2, mNeil3, NTH1, and OGG1) on these lesion-containing quadruplex substrates and found that only mNeil3 had excision activity on Tg in quadruplex DNA and that the glycosylase exhibited a strong preference for Tg in the telomeric sequence context.	thymine glycol	219-221	nei like DNA glycosylase 1	Homo sapiens	80-85
23542007-5	2013	Furthermore, deletion of the disordered tail lacking both Tyr and Trp residues causes a red shift in NEIL1"s intrinsic Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the truncated protein, which also exhibits reduced stability compared to the native enzyme.	Tyrosine	58-61	nei like DNA glycosylase 1	Homo sapiens	101-106
23898192-5	2013	Furthermore, NEIL1 binds to 5-hydroxyuracil, the oxidative deamination product of C, in replication protein A-coated ssDNA template and inhibits DNA synthesis by DNA polymerase delta.	5-hydroxyuracil	28-43	nei like DNA glycosylase 1	Homo sapiens	13-18
23542007-5	2013	Furthermore, deletion of the disordered tail lacking both Tyr and Trp residues causes a red shift in NEIL1"s intrinsic Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the truncated protein, which also exhibits reduced stability compared to the native enzyme.	Tryptophan	66-69	nei like DNA glycosylase 1	Homo sapiens	101-106
23542007-5	2013	Furthermore, deletion of the disordered tail lacking both Tyr and Trp residues causes a red shift in NEIL1"s intrinsic Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the truncated protein, which also exhibits reduced stability compared to the native enzyme.	Tryptophan	119-122	nei like DNA glycosylase 1	Homo sapiens	101-106
23542007-5	2013	Furthermore, deletion of the disordered tail lacking both Tyr and Trp residues causes a red shift in NEIL1"s intrinsic Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the truncated protein, which also exhibits reduced stability compared to the native enzyme.	Tryptophan	119-122	nei like DNA glycosylase 1	Homo sapiens	101-106
23542007-6	2013	These observations are consistent with stabilization of the native NEIL1 structure via intramolecular, mostly electrostatic, interactions that were disrupted by mutating a positively charged (Lys-rich) cluster of residues (amino acids 355-360) near the C-terminus.	Lysine	192-195	nei like DNA glycosylase 1	Homo sapiens	67-72
23268652-6	2013	Both hNEIL1 and (15)N-hNEIL1 were hydrolyzed with trypsin, and 18 tryptic peptides from each protein were identified by LC-MS/MS on the basis of their full-scan mass spectra.	Peptides	74-82	nei like DNA glycosylase 1	Homo sapiens	5-11
23508956-0	2013	NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.	Ficusin	28-36	nei like DNA glycosylase 1	Homo sapiens	0-5
23508956-2	2013	Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.	Ficusin	245-253	nei like DNA glycosylase 1	Homo sapiens	169-174
23508956-2	2013	Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.	angelicin	302-311	nei like DNA glycosylase 1	Homo sapiens	169-174
23508956-6	2013	Knockdown of NEIL1 in LN428 glioblastoma cells resulted in enhanced recruitment of XPC, a more rapid removal of digoxigenin-tagged psoralen adducts, and decreased cellular sensitivity to trioxsalen plus UVA, implying that NEIL1 and BER may interfere with normal cellular processing of interstrand crosslinks.	Digoxigenin	112-123	nei like DNA glycosylase 1	Homo sapiens	13-18
23508956-6	2013	Knockdown of NEIL1 in LN428 glioblastoma cells resulted in enhanced recruitment of XPC, a more rapid removal of digoxigenin-tagged psoralen adducts, and decreased cellular sensitivity to trioxsalen plus UVA, implying that NEIL1 and BER may interfere with normal cellular processing of interstrand crosslinks.	Trioxsalen	187-197	nei like DNA glycosylase 1	Homo sapiens	13-18
23508956-7	2013	While exhibiting no enzymatic activity, purified NEIL1 protein bound stably to psoralen interstrand crosslink-containing synthetic oligonucleotide substrates in vitro.	Oligonucleotides	131-146	nei like DNA glycosylase 1	Homo sapiens	49-54
23508956-2	2013	Employing fluorescently tagged fusion proteins and laser microirradiation coupled with confocal microscopy, we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidative DNA damage, as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts.	Trioxsalen	233-243	nei like DNA glycosylase 1	Homo sapiens	169-174
23268652-6	2013	Both hNEIL1 and (15)N-hNEIL1 were hydrolyzed with trypsin, and 18 tryptic peptides from each protein were identified by LC-MS/MS on the basis of their full-scan mass spectra.	Peptides	74-82	nei like DNA glycosylase 1	Homo sapiens	22-28
22286769-10	2012	5-Aza-2"-deoxycytidine treatment and DNMT1 knockdown resulted in the re-expression of NEIL1 in HNSCC cell lines, which initially carried hypermethylated promoter regions.	Decitabine	0-22	nei like DNA glycosylase 1	Homo sapiens	86-91
22170059-0	2012	Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.	thymine glycol	86-100	nei like DNA glycosylase 1	Homo sapiens	71-76
22914735-6	2012	In vitro, purified human NEIL1 protein binds and excises 5-hydroxycytosine in duplex DNA more efficiently than in hairpin substrates.	5-hydroxycytosine	57-74	nei like DNA glycosylase 1	Homo sapiens	25-30
22914735-7	2012	NEIL1 excision of cytosine-derived oxidative lesions could therefore be involved in initiating the process of TNR expansion, although other DNA modifications might also contribute.	Cytosine	18-26	nei like DNA glycosylase 1	Homo sapiens	0-5
22858590-2	2012	The human endonuclease VIII homologue NEIL1 removes a broad spectrum of oxidized pyrimidine and purine lesions.	pyrimidine	81-91	nei like DNA glycosylase 1	Homo sapiens	10-27
22858590-2	2012	The human endonuclease VIII homologue NEIL1 removes a broad spectrum of oxidized pyrimidine and purine lesions.	pyrimidine	81-91	nei like DNA glycosylase 1	Homo sapiens	38-43
22858590-2	2012	The human endonuclease VIII homologue NEIL1 removes a broad spectrum of oxidized pyrimidine and purine lesions.	purine	96-102	nei like DNA glycosylase 1	Homo sapiens	10-27
22858590-2	2012	The human endonuclease VIII homologue NEIL1 removes a broad spectrum of oxidized pyrimidine and purine lesions.	purine	96-102	nei like DNA glycosylase 1	Homo sapiens	38-43
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5-hydroxycytosine	59-76	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5-ohc	78-83	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5-hydroxyuracil	89-104	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5-ohu	106-111	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5,6-dihydrothymine	233-247	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	5,6-dihydrothymine	249-252	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	dihydrouracil	258-271	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-4	2012	Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA.	dihydrouracil	273-276	nei like DNA glycosylase 1	Homo sapiens	28-33
22858590-5	2012	NEIL1 excised 8-oxoguanine (8-oxoG) only from double-stranded DNA and analysis of site-specific mutants revealed that Met81, Arg119 and Phe120 are essential for removal of 8-oxoG.	8-hydroxyguanine	14-26	nei like DNA glycosylase 1	Homo sapiens	0-5
23926464-4	2012	Here, we show that truncated NEIL1 lacking the CID is markedly deficient in initiating in vitro repair of 5-hydroxyuracil (an oxidative deamination product of C) in a plasmid substrate compared to the wild-type NEIL1, thus suggesting a critical role of CID in the coordination of overall repair.	5-hydroxyuracil	106-121	nei like DNA glycosylase 1	Homo sapiens	29-34
23926464-5	2012	Furthermore, while NEIL1 downregulation significantly sensitized human embryonic kidney (HEK) 293 cells to reactive oxygen species (ROS), ectopic wild-type NEIL1, but not the truncated mutant, restored resistance to ROS.	Reactive Oxygen Species	107-130	nei like DNA glycosylase 1	Homo sapiens	19-24
22902625-6	2012	hnRNP-U stimulates the NEIL1 in vitro base excision activity for 5-hydroxyuracil in duplex, bubble, forked, or single-stranded DNA substrate, primarily by enhancing product release.	5-hydroxyuracil	65-80	nei like DNA glycosylase 1	Homo sapiens	23-28
22639086-0	2012	NEIL1 binding to DNA containing 2"-fluorothymidine glycol stereoisomers and the effect of editing.	2"-fluorothymidine glycol	32-57	nei like DNA glycosylase 1	Homo sapiens	0-5
22639086-1	2012	Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III.	thymine glycol	0-14	nei like DNA glycosylase 1	Homo sapiens	133-138
22639086-1	2012	Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III.	thymine glycol	16-18	nei like DNA glycosylase 1	Homo sapiens	133-138
22639086-1	2012	Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III.	Reactive Oxygen Species	64-87	nei like DNA glycosylase 1	Homo sapiens	133-138
22639086-2	2012	In our recent studies, we showed that NEIL1"s catalytic efficiency and lesion specificity are regulated by an RNA-editing adenosine deamination reaction.	Adenosine	122-131	nei like DNA glycosylase 1	Homo sapiens	38-43
22465744-0	2012	A DNA oligomer containing 2,2,4-triamino-5(2H)-oxazolone is incised by human NEIL1 and NTH1.	2,2,4-triamino-5(2H)-oxazolone	26-56	nei like DNA glycosylase 1	Homo sapiens	77-82
22170059-0	2012	Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.	5-hydroxyuracil	104-119	nei like DNA glycosylase 1	Homo sapiens	71-76
22170059-1	2012	Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and endonuclease VIII (Nei).	thymine glycol	0-14	nei like DNA glycosylase 1	Homo sapiens	214-231
22170059-1	2012	Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and endonuclease VIII (Nei).	thymine glycol	16-18	nei like DNA glycosylase 1	Homo sapiens	214-231
22170059-1	2012	Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and endonuclease VIII (Nei).	5-hydroxyuracil	24-39	nei like DNA glycosylase 1	Homo sapiens	214-231
22170059-1	2012	Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and endonuclease VIII (Nei).	5-ohu	41-46	nei like DNA glycosylase 1	Homo sapiens	214-231
22170059-1	2012	Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, endonuclease III (Nth) and endonuclease VIII (Nei).	Pyrimidines	80-91	nei like DNA glycosylase 1	Homo sapiens	214-231
22510596-2	2012	NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII and a major DNA glycosylase, initiates repair of oxidized pyrimidines.	Pyrimidines	125-136	nei like DNA glycosylase 1	Homo sapiens	0-5
22749143-2	2012	The bifunctional formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) are members of the Fpg/Nei family, one of the two families of glycosylases that recognize oxidized DNA bases, the other being the HhH/GPD (or Nth) superfamily.	formamidopyrimidine	17-36	nei like DNA glycosylase 1	Homo sapiens	63-80
21131780-6	2010	We observed specific ablation of the mixed function DNA glycosylase/lyase Neil1 phenotypically enhanced several inhibitors of thymidine biosynthesis, as well as cellular phenotypes downstream of gemcitabine, cytarabine and clofarabine exposure.	Thymidine	126-135	nei like DNA glycosylase 1	Homo sapiens	74-79
21697813-0	2011	Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.	Steroids	93-100	nei like DNA glycosylase 1	Homo sapiens	38-43
21799731-10	2011	Importantly, a number of redundant DNA glycosylase activities can excise hydantoin residues, including human NTH1, NEIL1 and NEIL2 and the former protein being a major DNA glycosylase activity in HeLa cells extracts.	Hydantoins	73-82	nei like DNA glycosylase 1	Homo sapiens	115-120
21131780-6	2010	We observed specific ablation of the mixed function DNA glycosylase/lyase Neil1 phenotypically enhanced several inhibitors of thymidine biosynthesis, as well as cellular phenotypes downstream of gemcitabine, cytarabine and clofarabine exposure.	gemcitabine	195-206	nei like DNA glycosylase 1	Homo sapiens	74-79
21131780-6	2010	We observed specific ablation of the mixed function DNA glycosylase/lyase Neil1 phenotypically enhanced several inhibitors of thymidine biosynthesis, as well as cellular phenotypes downstream of gemcitabine, cytarabine and clofarabine exposure.	Cytarabine	208-218	nei like DNA glycosylase 1	Homo sapiens	74-79
21131780-6	2010	We observed specific ablation of the mixed function DNA glycosylase/lyase Neil1 phenotypically enhanced several inhibitors of thymidine biosynthesis, as well as cellular phenotypes downstream of gemcitabine, cytarabine and clofarabine exposure.	Clofarabine	223-234	nei like DNA glycosylase 1	Homo sapiens	74-79
21131780-8	2010	Significantly, following TS pathway inhibition, addition of exogenous dTTP complemented the primary Neil1 gamma-H2A.X phenotypes.	thymidine 5'-triphosphate	70-74	nei like DNA glycosylase 1	Homo sapiens	100-105
21131780-11	2010	These data suggest Neil1 may be a critical mediator of BER of incorporated dUMP following TS pathway inhibition.	2'-deoxyuridylic acid	75-79	nei like DNA glycosylase 1	Homo sapiens	19-24
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	Iron	18-20	nei like DNA glycosylase 1	Homo sapiens	72-77
21068368-1	2010	Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein.	Lysine	65-71	nei like DNA glycosylase 1	Homo sapiens	50-55
21068368-1	2010	Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein.	Arginine	75-83	nei like DNA glycosylase 1	Homo sapiens	50-55
21068368-3	2010	The edited form removes thymine glycol from duplex DNA 30 times more slowly than the form encoded in the genome, whereas editing enhances repair of the guanidinohydantoin lesion by NEIL1.	thymine glycol	24-38	nei like DNA glycosylase 1	Homo sapiens	181-186
21068368-3	2010	The edited form removes thymine glycol from duplex DNA 30 times more slowly than the form encoded in the genome, whereas editing enhances repair of the guanidinohydantoin lesion by NEIL1.	guanidinohydantoin	152-170	nei like DNA glycosylase 1	Homo sapiens	181-186
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	cu(ii)	33-39	nei like DNA glycosylase 1	Homo sapiens	72-77
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	5-hydroxyuracil	164-179	nei like DNA glycosylase 1	Homo sapiens	72-77
20622253-4	2010	Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs.	Cytosine	190-198	nei like DNA glycosylase 1	Homo sapiens	72-77
20622253-7	2010	Furthermore, Fe(II) inhibits the interaction of NEIL1 with downstream base excision repair proteins DNA polymerase beta and flap endonuclease-1 by 4-6-fold.	ammonium ferrous sulfate	13-19	nei like DNA glycosylase 1	Homo sapiens	48-53
20338831-6	2010	RPA inhibits the base excision activity of both wild-type NEIL1 (389 residues) and its C-terminal deletion CDelta78 mutant (lacking the interaction domain) for repairing 5-hydroxyuracil (5-OHU) in a primer-template structure mimicking the DNA replication fork.	5-hydroxyuracil	170-185	nei like DNA glycosylase 1	Homo sapiens	58-63
20338831-6	2010	RPA inhibits the base excision activity of both wild-type NEIL1 (389 residues) and its C-terminal deletion CDelta78 mutant (lacking the interaction domain) for repairing 5-hydroxyuracil (5-OHU) in a primer-template structure mimicking the DNA replication fork.	5-ohu	187-192	nei like DNA glycosylase 1	Homo sapiens	58-63
20346739-1	2010	NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc.	Purines	118-125	nei like DNA glycosylase 1	Homo sapiens	0-5
20346739-1	2010	NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc.	saturated pyrimidines	127-148	nei like DNA glycosylase 1	Homo sapiens	0-5
20346739-1	2010	NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc.	5-hydroxyuracil	184-199	nei like DNA glycosylase 1	Homo sapiens	0-5
20346739-1	2010	NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc.	5-hydroxycytosine	201-218	nei like DNA glycosylase 1	Homo sapiens	0-5
20197241-3	2010	The DNA glycosylases, OGG1, MUTYH, NTH1, and NEIL1, in 293T cells were individually knocked-down by siRNAs and plasmid DNAs containing an 8-oxo-Gua:C/8-oxo-Gua:A pair, and 8-oxo-dGTP plus unmodified plasmid DNA were then introduced into the knocked-down cells.	8-hydroxyguanine	138-147	nei like DNA glycosylase 1	Homo sapiens	45-50
20099873-0	2010	Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.	Hydantoins	41-50	nei like DNA glycosylase 1	Homo sapiens	24-29
20214901-0	2010	The role of mammalian NEIL1 protein in the repair of 8-oxo-7,8-dihydroadenine in DNA.	8-oxo-7,8-dihydroadenine	53-77	nei like DNA glycosylase 1	Homo sapiens	22-27
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	136-144	nei like DNA glycosylase 1	Homo sapiens	19-36
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	136-144	nei like DNA glycosylase 1	Homo sapiens	53-58
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	136-144	nei like DNA glycosylase 1	Homo sapiens	94-111
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	150-158	nei like DNA glycosylase 1	Homo sapiens	19-36
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	150-158	nei like DNA glycosylase 1	Homo sapiens	53-58
20214901-3	2010	We have found that endonuclease VIII-like protein 1 (NEIL1), a mammalian homolog of bacterial endonuclease VIII, can efficiently remove 8-oxoAde from 8-oxoAde:Cyt pairs but not from other contexts.	8-oxo-7,8-dihydroadenine	150-158	nei like DNA glycosylase 1	Homo sapiens	94-111
20214901-4	2010	In an in vitro reconstituted system, reactions containing OGG1 produced a fully repaired product, whereas NEIL1 caused an abortive initiation of repair, stopping after 8-oxoAde removal and DNA strand cleavage.	8-oxo-7,8-dihydroadenine	168-176	nei like DNA glycosylase 1	Homo sapiens	106-111
20099873-1	2010	Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from duplex DNA in comparison to other substrates.	Guanine	75-82	nei like DNA glycosylase 1	Homo sapiens	22-27
20099873-1	2010	Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from duplex DNA in comparison to other substrates.	guanidinohydantoin	91-109	nei like DNA glycosylase 1	Homo sapiens	22-27
20099873-1	2010	Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from duplex DNA in comparison to other substrates.	spiroiminodihydantoin	119-140	nei like DNA glycosylase 1	Homo sapiens	22-27
20099873-1	2010	Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from duplex DNA in comparison to other substrates.	spiroiminodihydantoin	142-144	nei like DNA glycosylase 1	Homo sapiens	22-27
20099873-2	2010	In this work, Gh and Sp lesions in bubble, bulge, and single-stranded DNA were found to be good substrates for NEIL1 but were typically excised at much slower rates than from canonical duplex substrates.	spiroiminodihydantoin	21-23	nei like DNA glycosylase 1	Homo sapiens	111-116
20074151-10	2010	The antioxidant N-acetyl cystein (NAC) efficiently reversed the NEIL1 repression by inhibiting ROS induction by HCV.	n-acetyl cystein	16-32	nei like DNA glycosylase 1	Homo sapiens	64-69
20014751-11	2010	These results, when coupled with the known diastereomeric preference for excision of hydantoin lesions by the hNEIL1 enzyme, show the importance of defining both levels of lesion formation and diastereomeric preference of formation with regard to their potential impact on chromate carcinogenesis.	Hydantoins	85-94	nei like DNA glycosylase 1	Homo sapiens	110-116
20007945-4	2010	RESULTS In subjects with 2-h plasma glucose <140 mg/dl, the incidence of type 2 diabetes increased with increasing fasting plasma glucose (FPG) and 1-h and 2-h plasma glucose concentrations.	Glucose	36-43	nei like DNA glycosylase 1	Homo sapiens	126-160
20074151-10	2010	The antioxidant N-acetyl cystein (NAC) efficiently reversed the NEIL1 repression by inhibiting ROS induction by HCV.	nac	34-37	nei like DNA glycosylase 1	Homo sapiens	64-69
20074151-10	2010	The antioxidant N-acetyl cystein (NAC) efficiently reversed the NEIL1 repression by inhibiting ROS induction by HCV.	Reactive Oxygen Species	95-98	nei like DNA glycosylase 1	Homo sapiens	64-69
18032376-6	2008	PCNA stimulates NEIL1 activity in excising the oxidized base 5-hydroxyuracil from single-stranded DNA sequences including fork structures.	5-hydroxyuracil	61-76	nei like DNA glycosylase 1	Homo sapiens	16-21
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	ALUMINUM ION	23-27	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Nickel(2+)	29-33	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Cobalt(2+)	35-39	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	cupric ion	47-51	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Zinc	53-57	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	ammonium ferrous sulfate	63-67	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Tris hydrochloride	71-79	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	Zinc	100-104	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	cupric ion	106-110	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	ammonium ferrous sulfate	116-120	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	potassium phosphate	124-143	nei like DNA glycosylase 1	Homo sapiens	0-5
19916941-6	2009	Fpg and Nei, the prokaryotic homologs of NEIL1, were inhibited by the same metal ions as NEIL1.	Metals	75-80	nei like DNA glycosylase 1	Homo sapiens	41-46
19916941-7	2009	The values of I(50) for NEIL1 inhibition were 7 microM for Cd2+, 16 microM for Zn2+, and 400 microM for Cu2+.	Zinc	79-83	nei like DNA glycosylase 1	Homo sapiens	24-29
19916941-7	2009	The values of I(50) for NEIL1 inhibition were 7 microM for Cd2+, 16 microM for Zn2+, and 400 microM for Cu2+.	cupric ion	104-108	nei like DNA glycosylase 1	Homo sapiens	24-29
19916941-8	2009	The inhibition of NEIL1 by Cd2+, Zn2+, and Cu2+ was at least partly due to the formation of metal-DNA complexes.	Zinc	33-37	nei like DNA glycosylase 1	Homo sapiens	18-23
19916941-8	2009	The inhibition of NEIL1 by Cd2+, Zn2+, and Cu2+ was at least partly due to the formation of metal-DNA complexes.	cupric ion	43-47	nei like DNA glycosylase 1	Homo sapiens	18-23
19916941-8	2009	The inhibition of NEIL1 by Cd2+, Zn2+, and Cu2+ was at least partly due to the formation of metal-DNA complexes.	Metals	92-97	nei like DNA glycosylase 1	Homo sapiens	18-23
19916941-10	2009	Therefore, the inhibition of NEIL1 activity in removal of oxidative lesions by heavy metal ions may be a reason for their co-mutagenicity under oxidative stress.	Metals	85-90	nei like DNA glycosylase 1	Homo sapiens	29-34
19625256-2	2009	We determined the crystal structures of a NEIL1 ortholog from the giant Mimivirus (MvNei1) unliganded and bound to DNA containing tetrahydrofuran (THF), which is the first structure of any Nei with an abasic site analog.	tetrahydrofuran	130-145	nei like DNA glycosylase 1	Homo sapiens	42-47
19625256-2	2009	We determined the crystal structures of a NEIL1 ortholog from the giant Mimivirus (MvNei1) unliganded and bound to DNA containing tetrahydrofuran (THF), which is the first structure of any Nei with an abasic site analog.	tetrahydrofuran	147-150	nei like DNA glycosylase 1	Homo sapiens	42-47
19443904-6	2009	The NEIL1 G83D mutant was dysfunctional for the major oxidation products 7,8-dihydro-8-oxoguanine (8oxoG), thymine glycol and dihydrothymine in duplex DNA, and the ability to perform delta-elimination at abasic sites was significantly reduced.	7,8-dihydro-8-oxoguanine	73-97	nei like DNA glycosylase 1	Homo sapiens	4-9
19443904-6	2009	The NEIL1 G83D mutant was dysfunctional for the major oxidation products 7,8-dihydro-8-oxoguanine (8oxoG), thymine glycol and dihydrothymine in duplex DNA, and the ability to perform delta-elimination at abasic sites was significantly reduced.	thymine glycol	107-121	nei like DNA glycosylase 1	Homo sapiens	4-9
19443904-6	2009	The NEIL1 G83D mutant was dysfunctional for the major oxidation products 7,8-dihydro-8-oxoguanine (8oxoG), thymine glycol and dihydrothymine in duplex DNA, and the ability to perform delta-elimination at abasic sites was significantly reduced.	5,6-dihydrothymine	126-140	nei like DNA glycosylase 1	Homo sapiens	4-9
18543945-0	2008	Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.	Hydantoins	20-29	nei like DNA glycosylase 1	Homo sapiens	100-106
18543945-1	2008	The DNA glycosylase hNEIL1 initiates the base excision repair (BER) of a diverse array of lesions, including ring-opened purines and saturated pyrimidines.	Purines	121-128	nei like DNA glycosylase 1	Homo sapiens	20-26
18543945-1	2008	The DNA glycosylase hNEIL1 initiates the base excision repair (BER) of a diverse array of lesions, including ring-opened purines and saturated pyrimidines.	saturated pyrimidines	133-154	nei like DNA glycosylase 1	Homo sapiens	20-26
19258314-1	2009	Previously, we have demonstrated that human oxidative DNA glycosylase NEIL1 excises photoactivated psoralen-induced monoadducts but not genuine interstrand cross-links (ICLs) in duplex DNA.	Ficusin	99-107	nei like DNA glycosylase 1	Homo sapiens	70-75
19179336-0	2009	Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.	formamidopyrimidines	55-75	nei like DNA glycosylase 1	Homo sapiens	79-84
19179336-9	2009	These results suggest that CSB plays a role in repair of formamidopyrimidines, possibly by interacting with and stimulating NEIL1, and that accumulation of such modifications may have a causal role in the pathogenesis of CS.	formamidopyrimidines	57-77	nei like DNA glycosylase 1	Homo sapiens	124-129
18662981-4	2008	FEN-1 stimulates the activity of NEIL1 in vitro in excising 5-hydroxyuracil from duplex, bubble, forked, and single-stranded DNA substrates by up to 5-fold.	5-hydroxyuracil	60-75	nei like DNA glycosylase 1	Homo sapiens	33-38
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Lysine	42-45	nei like DNA glycosylase 1	Homo sapiens	130-135
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Arginine	50-53	nei like DNA glycosylase 1	Homo sapiens	130-135
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Aspartic Acid	106-109	nei like DNA glycosylase 1	Homo sapiens	130-135
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Glutamic Acid	114-117	nei like DNA glycosylase 1	Homo sapiens	130-135
18543945-3	2008	In order to provide insight into the role of repair, the excision efficiency by hNEIL1 of these hydantoin lesions relative to other known substrates was determined.	Hydantoins	96-105	nei like DNA glycosylase 1	Homo sapiens	80-86
18543945-4	2008	Most notably, quantitative examination of the substrate specificity with hNEIL1 revealed that the hydantoin lesions are excised much more efficiently (>100-fold faster) than the reported standard substrates thymine glycol (Tg) and 5-hydroxycytosine (5-OHC).	Hydantoins	98-107	nei like DNA glycosylase 1	Homo sapiens	73-79
18543945-4	2008	Most notably, quantitative examination of the substrate specificity with hNEIL1 revealed that the hydantoin lesions are excised much more efficiently (>100-fold faster) than the reported standard substrates thymine glycol (Tg) and 5-hydroxycytosine (5-OHC).	5-ohc	253-258	nei like DNA glycosylase 1	Homo sapiens	73-79
18543945-6	2008	The activity of hNEIL1 is also influenced by the base pair partner of the lesion, with both Gh and Sp removal being more efficient when paired with T, G, or C than when paired with A.	TFF2 protein, human	99-101	nei like DNA glycosylase 1	Homo sapiens	16-22
18473721-3	2008	Strand breaks that are caused by many agents including ionizing radiation, topoisomerase I inhibitors, and DNA repair glycosylases such as NEIL1 and NEIL2, often contain 5"-hydroxyl and/or 3"-phosphate termini.	5"-hydroxyl	170-181	nei like DNA glycosylase 1	Homo sapiens	139-144
18473721-3	2008	Strand breaks that are caused by many agents including ionizing radiation, topoisomerase I inhibitors, and DNA repair glycosylases such as NEIL1 and NEIL2, often contain 5"-hydroxyl and/or 3"-phosphate termini.	Phosphates	192-201	nei like DNA glycosylase 1	Homo sapiens	139-144
18155253-3	2008	OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.	8-ohdg	71-78	nei like DNA glycosylase 1	Homo sapiens	6-11
17954039-6	2008	Data obtained from oxanine DNA cleavage assays using purified human glycosylases demonstrated that two known glycosylases, hNEIL1 and hSMUG1, contained weak but detectable ODG activities.	oxanine	19-26	nei like DNA glycosylase 1	Homo sapiens	123-129
17954039-6	2008	Data obtained from oxanine DNA cleavage assays using purified human glycosylases demonstrated that two known glycosylases, hNEIL1 and hSMUG1, contained weak but detectable ODG activities.	BMP15 protein, human	172-175	nei like DNA glycosylase 1	Homo sapiens	123-129
17556049-1	2007	The DNA glycosylase hNEIL1 initiates base excision repair (BER) of a number of oxidized purines and pyrimidines in cellular DNA and is one of three mammalian orthologs of the Escherichia coli Nei/Fpg enzymes.	Purines	88-95	nei like DNA glycosylase 1	Homo sapiens	20-26
17627905-1	2007	Endonuclease VIII (Nei), which recognizes and repairs oxidized pyrimidines in the base excision repair (BER) pathway, is sparsely distributed among both the prokaryotes and eukaryotes.	Pyrimidines	63-74	nei like DNA glycosylase 1	Homo sapiens	0-17
17627905-7	2007	Finally, a conserved arginine residue in the "zincless finger" motif, previously identified in human NEIL1, is required for the DNA glycosylase activity of MvNei1.	Arginine	21-29	nei like DNA glycosylase 1	Homo sapiens	101-106
17556049-1	2007	The DNA glycosylase hNEIL1 initiates base excision repair (BER) of a number of oxidized purines and pyrimidines in cellular DNA and is one of three mammalian orthologs of the Escherichia coli Nei/Fpg enzymes.	Pyrimidines	100-111	nei like DNA glycosylase 1	Homo sapiens	20-26
17389588-1	2007	In mammalian cells, the repair of DNA bases that have been damaged by reactive oxygen species is primarily initiated by a series of DNA glycosylases that include OGG1, NTH1, NEIL1, and NEIL2.	Reactive Oxygen Species	70-93	nei like DNA glycosylase 1	Homo sapiens	174-179
17611195-1	2007	The mammalian DNA glycosylase, NEIL1, specific for repair of oxidatively damaged bases in the genome via the base excision repair pathway, is activated by reactive oxygen species and prevents toxicity due to radiation.	Reactive Oxygen Species	155-178	nei like DNA glycosylase 1	Homo sapiens	31-36
17432829-2	2007	Human Neil1, a versatile glycosylase in the BER pathway, repairs a diverse array of oxidative lesions; however, the most prevalent, 8-oxo-7,8-dihydroguanine (8-oxoG), is only weakly excised.	8-hydroxyguanine	132-156	nei like DNA glycosylase 1	Homo sapiens	6-11
17432829-2	2007	Human Neil1, a versatile glycosylase in the BER pathway, repairs a diverse array of oxidative lesions; however, the most prevalent, 8-oxo-7,8-dihydroguanine (8-oxoG), is only weakly excised.	8-hydroxyguanine	158-164	nei like DNA glycosylase 1	Homo sapiens	6-11
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	r- and s-spiroiminodihydantoin	179-209	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	spiroiminodihydantoin	211-213	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	Guanine	270-277	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	5r,6s	287-292	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	CHEMBL3739852	298-300	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	6r-thymine glycol	301-318	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	Thioguanine	320-322	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	Thymine	304-311	nei like DNA glycosylase 1	Homo sapiens	47-53
17432829-7	2007	The results of our investigations provide structural explanations for the ability of hNeil1 to excise a variety of oxidative lesions: they possess common chemical features, namely, a pyrimidine-like ring and shared hydrogen bond donor-acceptor properties, which allow the lesions to fit well in the binding pocket, which is somewhat flexible.	pyrimidine	183-193	nei like DNA glycosylase 1	Homo sapiens	85-91
17432829-7	2007	The results of our investigations provide structural explanations for the ability of hNeil1 to excise a variety of oxidative lesions: they possess common chemical features, namely, a pyrimidine-like ring and shared hydrogen bond donor-acceptor properties, which allow the lesions to fit well in the binding pocket, which is somewhat flexible.	Hydrogen	215-223	nei like DNA glycosylase 1	Homo sapiens	85-91
17715144-6	2007	The results show that in human cells DNA glycosylase NEIL1 excises the MAs in duplex DNA, subsequently the apurinic/apyrimidinic endonuclease 1, APE1, removes the 3"-phosphate residue at single-strand break generated by NEIL1.	Phosphates	166-175	nei like DNA glycosylase 1	Homo sapiens	53-58
17348689-0	2007	NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.	5-hydroxyuracil	50-65	nei like DNA glycosylase 1	Homo sapiens	0-5
16978929-6	2007	The apparent kinetic parameters of the reactions suggest that Ape1 and the DNA glycosylases/AP lyases, hNth1 and hNeil1 repair 5ohC with a low efficiency.	5ohc	127-131	nei like DNA glycosylase 1	Homo sapiens	113-119
17715144-6	2007	The results show that in human cells DNA glycosylase NEIL1 excises the MAs in duplex DNA, subsequently the apurinic/apyrimidinic endonuclease 1, APE1, removes the 3"-phosphate residue at single-strand break generated by NEIL1.	Phosphates	166-175	nei like DNA glycosylase 1	Homo sapiens	220-225
15907775-3	2005	A duplex 30-mer (duplex1920) containing tandem DHU lesions at positions 19 and 20 from the 5" terminus was used as a substrate for human endonuclease III (hNTH) and endonuclease VIII (NEIL1).	dihydrouracil	47-50	nei like DNA glycosylase 1	Homo sapiens	165-182
16446124-0	2006	Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization.	thymine glycol	10-24	nei like DNA glycosylase 1	Homo sapiens	38-44
16446124-6	2006	In contrast, hNeil1 released Tg non-stereoselectively, but the rate of excision was much greater when Tg opposed guanine.	Thioguanine	29-31	nei like DNA glycosylase 1	Homo sapiens	13-19
16118226-0	2005	Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species.	Reactive Oxygen Species	71-94	nei like DNA glycosylase 1	Homo sapiens	62-67
16118226-2	2005	Exposure of HCT116 human colon carcinoma cells to reactive oxygen species, generated by glucose oxidase (GO), enhanced the levels of NEIL1 mRNA and polypeptide by 2-4-fold by 6 h after GO treatment.	Reactive Oxygen Species	50-73	nei like DNA glycosylase 1	Homo sapiens	133-138
16118226-3	2005	A similar oxidative stress-induced increase in human NEIL1 (hNEIL1) promoter-dependent luciferase expression in HCT116 cells indicates that reactive oxygen species activates NEIL1 transcription.	Reactive Oxygen Species	140-163	nei like DNA glycosylase 1	Homo sapiens	53-58
16118226-3	2005	A similar oxidative stress-induced increase in human NEIL1 (hNEIL1) promoter-dependent luciferase expression in HCT116 cells indicates that reactive oxygen species activates NEIL1 transcription.	Reactive Oxygen Species	140-163	nei like DNA glycosylase 1	Homo sapiens	60-66
16118226-3	2005	A similar oxidative stress-induced increase in human NEIL1 (hNEIL1) promoter-dependent luciferase expression in HCT116 cells indicates that reactive oxygen species activates NEIL1 transcription.	Reactive Oxygen Species	140-163	nei like DNA glycosylase 1	Homo sapiens	61-66
17395641-5	2007	A significant fraction of the hNEIL1 nuclear foci co-localize with hRad9 foci in hydrogen peroxide treated cells.	Hydrogen Peroxide	81-98	nei like DNA glycosylase 1	Homo sapiens	30-36
16446448-4	2006	One enzyme that initiates base excision repair of ring-fragmented purines and some saturated pyrimidines is NEIL1, a mammalian homolog to Escherichia coli endonuclease VIII.	Purines	66-73	nei like DNA glycosylase 1	Homo sapiens	108-113
16446448-4	2006	One enzyme that initiates base excision repair of ring-fragmented purines and some saturated pyrimidines is NEIL1, a mammalian homolog to Escherichia coli endonuclease VIII.	Pyrimidines	93-104	nei like DNA glycosylase 1	Homo sapiens	108-113
15907775-3	2005	A duplex 30-mer (duplex1920) containing tandem DHU lesions at positions 19 and 20 from the 5" terminus was used as a substrate for human endonuclease III (hNTH) and endonuclease VIII (NEIL1).	dihydrouracil	47-50	nei like DNA glycosylase 1	Homo sapiens	184-189
15907775-10	2005	The 18p and 19p corresponded to the expected beta,delta-elimination products derived from NEIL1 induced cleavage at the 5"-DHU and 3"-DHU of the tandem DHU, respectively.	dihydrouracil	123-126	nei like DNA glycosylase 1	Homo sapiens	90-95
15907775-10	2005	The 18p and 19p corresponded to the expected beta,delta-elimination products derived from NEIL1 induced cleavage at the 5"-DHU and 3"-DHU of the tandem DHU, respectively.	dihydrouracil	134-137	nei like DNA glycosylase 1	Homo sapiens	90-95
15907775-13	2005	Together, we suggest that the processing of DNA-containing tandem DHU lesions, initiated by hNTH and NEIL1 can be channeled into two sub-pathways, the PNK-independent, APE1-dependent and the PNK, APE1-dependent pathways, respectively.	dihydrouracil	66-69	nei like DNA glycosylase 1	Homo sapiens	101-106
15533839-0	2005	DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.	Thymine	31-38	nei like DNA glycosylase 1	Homo sapiens	98-104
15533839-5	2005	In the present experiments, hNEIL1 protected the E. coli nth nei mutant from lethal effect of hydrogen peroxide and high frequency of spontaneous mutations under aerobic conditions.	Hydrogen Peroxide	94-111	nei like DNA glycosylase 1	Homo sapiens	28-34
15533836-0	2005	Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.	spiroiminodihydantoin	36-57	nei like DNA glycosylase 1	Homo sapiens	139-144
15533839-6	2005	Furthermore, hNEIL1 efficiently cleaved double stranded oligonucleotides containing 5-formyluracil (5-foU) and 5-hydroxymethyluracil (5-hmU) in vitro via beta- and delta-elimination reactions.	double stranded oligonucleotides	40-72	nei like DNA glycosylase 1	Homo sapiens	13-19
15533836-0	2005	Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.	guanidinohydantoin	62-80	nei like DNA glycosylase 1	Homo sapiens	139-144
15533836-7	2005	Herein we report that two recently identified mammalian glycosylases, NEIL1 and NEIL2, showed a high affinity for recognition and cleavage of DNA containing Gh/Ia and Sp lesions.	spiroiminodihydantoin	167-169	nei like DNA glycosylase 1	Homo sapiens	70-75
15533836-10	2005	NEIL1 was able to excise the Sp lesion opposite the four natural bases in double-stranded DNA, however, NEIL2 showed little cleavage activity against the Sp lesion in duplex DNA although DNA trapping studies show recognition and binding of NEIL2 to this lesion.	spiroiminodihydantoin	29-31	nei like DNA glycosylase 1	Homo sapiens	0-5
15533839-6	2005	Furthermore, hNEIL1 efficiently cleaved double stranded oligonucleotides containing 5-formyluracil (5-foU) and 5-hydroxymethyluracil (5-hmU) in vitro via beta- and delta-elimination reactions.	5-formyluracil	84-98	nei like DNA glycosylase 1	Homo sapiens	13-19
15533839-6	2005	Furthermore, hNEIL1 efficiently cleaved double stranded oligonucleotides containing 5-formyluracil (5-foU) and 5-hydroxymethyluracil (5-hmU) in vitro via beta- and delta-elimination reactions.	5-formyluracil	100-105	nei like DNA glycosylase 1	Homo sapiens	13-19
15533839-6	2005	Furthermore, hNEIL1 efficiently cleaved double stranded oligonucleotides containing 5-formyluracil (5-foU) and 5-hydroxymethyluracil (5-hmU) in vitro via beta- and delta-elimination reactions.	5-hydroxymethyluracil	111-132	nei like DNA glycosylase 1	Homo sapiens	13-19
15533839-6	2005	Furthermore, hNEIL1 efficiently cleaved double stranded oligonucleotides containing 5-formyluracil (5-foU) and 5-hydroxymethyluracil (5-hmU) in vitro via beta- and delta-elimination reactions.	5-hydroxymethyluracil	134-139	nei like DNA glycosylase 1	Homo sapiens	13-19
15319300-5	2004	When the excision repair activity towards double-stranded oligonucleotide containing a Tg:A base pair was compared among six types of recombinant NEIL1 proteins, p.Glu28del-type NEIL1, found in a primary case, was found to exhibit an extremely low activity level.	thymine glycol	87-89	nei like DNA glycosylase 1	Homo sapiens	178-183
15595846-6	2004	This finding establishes that mNEIL1 and its functional homologue hNEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.	2,6-diamino-4-hydroxy-5-formamidopyrimidine	108-151	nei like DNA glycosylase 1	Homo sapiens	66-72
15595846-6	2004	This finding establishes that mNEIL1 and its functional homologue hNEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.	4,6-diamino-5-N-formamidopyrimidine	156-189	nei like DNA glycosylase 1	Homo sapiens	66-72
15319300-5	2004	When the excision repair activity towards double-stranded oligonucleotide containing a Tg:A base pair was compared among six types of recombinant NEIL1 proteins, p.Glu28del-type NEIL1, found in a primary case, was found to exhibit an extremely low activity level.	double-stranded oligonucleotide	42-73	nei like DNA glycosylase 1	Homo sapiens	178-183
15232006-1	2004	In prokaryotes, two DNA glycosylases recognize and excise oxidized pyrimidines: endonuclease III (Nth) and endonuclease VIII (Nei).	Pyrimidines	67-78	nei like DNA glycosylase 1	Homo sapiens	107-124
15319300-5	2004	When the excision repair activity towards double-stranded oligonucleotide containing a Tg:A base pair was compared among six types of recombinant NEIL1 proteins, p.Glu28del-type NEIL1, found in a primary case, was found to exhibit an extremely low activity level.	thymine glycol	87-89	nei like DNA glycosylase 1	Homo sapiens	146-151
15350146-5	2004	This novel collaboration of two DNA glycosylases, which do not stably interact with each other, in stimulating 8-oxoguanine repair is possible because of higher AP site affinity and stronger AP lyase activity of NEIL1 relative to OGG1.	8-hydroxyguanine	111-123	nei like DNA glycosylase 1	Homo sapiens	212-217
15260972-2	2004	The recently discovered mammalian DNA glycosylase/AP lyases, NEIL1 and NEIL2, unlike the previously characterized OGG1 and NTH1, generate DNA strand breaks with 3" phosphate termini.	Phosphates	164-173	nei like DNA glycosylase 1	Homo sapiens	61-66
15232006-8	2004	This "zincless finger" appears to be required for NEIL1 activity, because mutating a very highly conserved arginine within this motif greatly reduces the glycosylase activity of the enzyme.	Arginine	107-115	nei like DNA glycosylase 1	Homo sapiens	50-55
14734554-1	2004	In human cells, oxidative pyrimidine lesions are restored by the base excision repair pathway initiated by homologues of Endo III (hNTH1) and Endo VIII (hNEIL1 and hNEIL2).	pyrimidine	26-36	nei like DNA glycosylase 1	Homo sapiens	153-159
15159582-2	2004	Recently, NEIL1, a human homolog of Escherichia coli DNA glycosylase endonuclease VIII, has been identified and shown to exhibit broad substrate specificity for a variety of types of pyrimidine-base damage.	pyrimidine	183-193	nei like DNA glycosylase 1	Homo sapiens	10-15
15330152-8	2004	Lucanthone also appears to inhibit exonuclease III family members (APE1 and ExoIII), but not endonuclease IV AP endonucleases, nor bifunctional glycosylase/lyases such as endonuclease VIII or formamidopyrimidine-DNA glycosylase (Fpg).	Lucanthone	0-10	nei like DNA glycosylase 1	Homo sapiens	171-188
14734554-3	2004	hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1.	thymine glycol	65-79	nei like DNA glycosylase 1	Homo sapiens	10-16
14734554-3	2004	hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1.	5r-tg	81-86	nei like DNA glycosylase 1	Homo sapiens	10-16
14734554-3	2004	hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1.	5s-tg	91-96	nei like DNA glycosylase 1	Homo sapiens	10-16
14734554-3	2004	hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1.	5r-tg	178-183	nei like DNA glycosylase 1	Homo sapiens	10-16
14734554-3	2004	hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1.	5s-tg	184-189	nei like DNA glycosylase 1	Homo sapiens	10-16
15056851-3	2004	In human cells, oxidative pyrimidine lesions are generally removed by hNTH1, hNEIL1, or hNEIL2, whereas oxidative purine lesions are removed by hOGG1.	pyrimidine	26-36	nei like DNA glycosylase 1	Homo sapiens	77-83
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Proline	115-118	nei like DNA glycosylase 1	Homo sapiens	77-83
15056851-8	2004	For cleavage of the N-glycosidic bond, bifunctional DNA glycosylases (hNTH1, hNEIL1, hNEIL2, and hOGG1) use Lys or Pro for direct attack on sugar C1", whereas monofunctional DNA glycosylases (hSMUG1 and hMYH) use an activated water molecule.	Water	226-231	nei like DNA glycosylase 1	Homo sapiens	77-83
17150535-3	2004	hNTH1 and hNEIL1 recognized a similar spectra of bases lesions, but the preference of damage including the stereoisomers of thymine glycol was significantly different between hNTH1 and hNEIL1.	thymine glycol	124-138	nei like DNA glycosylase 1	Homo sapiens	185-191
14734554-7	2004	hNEIL1, hNEIL2, and Endo VIII but not hNTH1 and Endo III formed cross-links to oxanine, suggesting conservation of the -fold of the active site of the Endo VIII homologues.	oxanine	79-86	nei like DNA glycosylase 1	Homo sapiens	0-6
14734554-9	2004	However, detailed analysis of the cellular activity suggests that hNEIL1 has a significant role in the repair of 5S-Tg in human cells.	5s-tg	113-118	nei like DNA glycosylase 1	Homo sapiens	66-72
12509226-4	2002	We have characterized one of these, hNEI1, and show it to be functionally homologous to bacterial Nei, that is, its principal substrates are oxidized pyrimidines, it undergoes a lyase reaction by, beta,delta-elimination and traps a Schiff base with a substrate containing thymine glycol (Tg).	Pyrimidines	150-161	nei like DNA glycosylase 1	Homo sapiens	36-41
14522990-4	2003	NEIL1 also excises efficiently 5-hydroxyuracil, an oxidation product of cytosine, from the bubble and single-stranded DNA but does not have strong activity toward 8-oxoguanine in the bubble.	5-hydroxyuracil	31-46	nei like DNA glycosylase 1	Homo sapiens	0-5
14522990-4	2003	NEIL1 also excises efficiently 5-hydroxyuracil, an oxidation product of cytosine, from the bubble and single-stranded DNA but does not have strong activity toward 8-oxoguanine in the bubble.	Cytosine	72-80	nei like DNA glycosylase 1	Homo sapiens	0-5
12433996-5	2002	hFPG1 was purified and shown to act on DNA substrates containing 8-oxoguanine, 5-hydroxycytosine and abasic sites.	8-hydroxyguanine	65-77	nei like DNA glycosylase 1	Homo sapiens	0-5
12433996-5	2002	hFPG1 was purified and shown to act on DNA substrates containing 8-oxoguanine, 5-hydroxycytosine and abasic sites.	5-hydroxycytosine	79-96	nei like DNA glycosylase 1	Homo sapiens	0-5
12097317-10	2002	NEIL2 is similar to NEIL1 in having N-terminal Pro as the active site.	Proline	47-50	nei like DNA glycosylase 1	Homo sapiens	20-25
12509226-4	2002	We have characterized one of these, hNEI1, and show it to be functionally homologous to bacterial Nei, that is, its principal substrates are oxidized pyrimidines, it undergoes a lyase reaction by, beta,delta-elimination and traps a Schiff base with a substrate containing thymine glycol (Tg).	Schiff Bases	232-243	nei like DNA glycosylase 1	Homo sapiens	36-41
12509226-4	2002	We have characterized one of these, hNEI1, and show it to be functionally homologous to bacterial Nei, that is, its principal substrates are oxidized pyrimidines, it undergoes a lyase reaction by, beta,delta-elimination and traps a Schiff base with a substrate containing thymine glycol (Tg).	thymine glycol	272-286	nei like DNA glycosylase 1	Homo sapiens	36-41
12509226-4	2002	We have characterized one of these, hNEI1, and show it to be functionally homologous to bacterial Nei, that is, its principal substrates are oxidized pyrimidines, it undergoes a lyase reaction by, beta,delta-elimination and traps a Schiff base with a substrate containing thymine glycol (Tg).	thymine glycol	288-290	nei like DNA glycosylase 1	Homo sapiens	36-41
10833024-1	2000	Electrospray mass spectrometry techniques were used to characterize components of the active site in Endonuclease VIII by identifying the amino acid sequence and the binding site for a tryptic peptide derived from Endo VIII in a cross-linked DNA-peptide complex.	Peptides	193-200	nei like DNA glycosylase 1	Homo sapiens	101-118
11904416-7	2002	The 44-kDa, wild-type recombinant NEH1, purified to homogeneity from E. coli, excises Fapys from damaged DNA, and oxidized pyrimidines and 8-oxoG from oligodeoxynucleotides.	Pyrimidines	123-134	nei like DNA glycosylase 1	Homo sapiens	34-38
11904416-7	2002	The 44-kDa, wild-type recombinant NEH1, purified to homogeneity from E. coli, excises Fapys from damaged DNA, and oxidized pyrimidines and 8-oxoG from oligodeoxynucleotides.	Oligodeoxyribonucleotides	151-172	nei like DNA glycosylase 1	Homo sapiens	34-38
33929180-0	2021	RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.	5-hydroxyuracil	69-84	nei like DNA glycosylase 1	Homo sapiens	41-46
34060590-1	2021	The oxidatively generated genotoxic spiroiminodihydantoin (Sp) lesions are well-known substrates of base excision repair (BER) pathway initiated by the bifunctional DNA glycosylase NEIL1.	spiroiminodihydantoin	36-57	nei like DNA glycosylase 1	Homo sapiens	181-186
34060590-1	2021	The oxidatively generated genotoxic spiroiminodihydantoin (Sp) lesions are well-known substrates of base excision repair (BER) pathway initiated by the bifunctional DNA glycosylase NEIL1.	spiroiminodihydantoin	59-61	nei like DNA glycosylase 1	Homo sapiens	181-186
34060590-2	2021	In this work we reported that the excision kinetics of the single Sp lesions site-specifically embedded in the covalently closed circular DNA plasmids (contour length 2686 base pairs) by NEIL1 are biphasic under single-turnover conditions ((NEIL1)>>(SpDNApl)) in contrast to monophasic excision kinetics of the same lesions embedded in147-mer Sp-modified DNA duplexes.	spiroiminodihydantoin	66-68	nei like DNA glycosylase 1	Homo sapiens	187-192
34060590-2	2021	In this work we reported that the excision kinetics of the single Sp lesions site-specifically embedded in the covalently closed circular DNA plasmids (contour length 2686 base pairs) by NEIL1 are biphasic under single-turnover conditions ((NEIL1)>>(SpDNApl)) in contrast to monophasic excision kinetics of the same lesions embedded in147-mer Sp-modified DNA duplexes.	spiroiminodihydantoin	66-68	nei like DNA glycosylase 1	Homo sapiens	241-246
35419789-6	2022	When the threshold of the FPG-1 + OGTT 1h + 2h-1 level in the first pregnancy was > 23.6 mmol/L, the specificity for predicting GDMR was 0.85, the sensitivity was 0.45, and the area under the receiver operating characteristic curve (ROC-AUC) was 0.70, indicating a 70% probability of predicting GDMR in the next pregnancy.	Hydrogen	39-41	nei like DNA glycosylase 1	Homo sapiens	26-31
35419789-7	2022	Logistic regression analysis showed that patients with a combined abnormal FPG-1 + OGTT 1h + 2 h-1 level had a 10-fold increased risk for GDMR in subsequent pregnancies than patients with normal indicators (OR: 10.542, 95% CI: 3.097-35.881; p < 0.0001).	Hydrogen	88-90	nei like DNA glycosylase 1	Homo sapiens	75-80
33929180-10	2021	Notably, nonproductive engagement of 5-OHU by Ed NEIL1 suggests the extent of 5-OHU repair will be reduced under cellular conditions, such as inflammation, that increase the extent of NEIL1 RNA editing.	5-ohu	78-83	nei like DNA glycosylase 1	Homo sapiens	184-189
33929180-1	2021	Editing of the pre-mRNA of the DNA repair glycosylase NEIL1 results in substitution of a Lys with Arg in the lesion recognition loop of the enzyme.	Lysine	89-92	nei like DNA glycosylase 1	Homo sapiens	54-59
33929180-1	2021	Editing of the pre-mRNA of the DNA repair glycosylase NEIL1 results in substitution of a Lys with Arg in the lesion recognition loop of the enzyme.	Arginine	98-101	nei like DNA glycosylase 1	Homo sapiens	54-59
33929180-2	2021	Unedited (UE, Lys242) NEIL1 removes thymine glycol lesions in DNA ~30 times faster than edited (Ed, Arg242) NEIL1.	thymine glycol	36-50	nei like DNA glycosylase 1	Homo sapiens	22-27
33929180-3	2021	Herein, we evaluated recognition and excision mediated by UE and Ed NEIL1 of 5-hydroxyuracil (5-OHU), a highly mutagenic lesion formed via oxidation of cytosine.	5-hydroxyuracil	77-92	nei like DNA glycosylase 1	Homo sapiens	68-73
33929180-3	2021	Herein, we evaluated recognition and excision mediated by UE and Ed NEIL1 of 5-hydroxyuracil (5-OHU), a highly mutagenic lesion formed via oxidation of cytosine.	5-ohu	94-99	nei like DNA glycosylase 1	Homo sapiens	68-73
33929180-4	2021	Both NEIL1 isoforms catalyzed low levels of 5-OHU excision in single-stranded DNA, bubble and bulge DNA contexts and in duplex DNA base paired with A.	5-ohu	44-49	nei like DNA glycosylase 1	Homo sapiens	5-10
33929180-5	2021	Removal of 5-OHU in base pairs with G, T, and C was found to be faster and proceed to a higher overall extent with UE than with Ed NEIL1.	5-ohu	11-16	nei like DNA glycosylase 1	Homo sapiens	131-136
33929180-7	2021	However, Ed NEIL1 was found to exhibit higher affinity for 5-OHU:G and 5-OHU:C duplexes than UE NEIL1.	5-ohu	59-64	nei like DNA glycosylase 1	Homo sapiens	12-17
33929180-7	2021	However, Ed NEIL1 was found to exhibit higher affinity for 5-OHU:G and 5-OHU:C duplexes than UE NEIL1.	5-ohu	59-64	nei like DNA glycosylase 1	Homo sapiens	96-101
33929180-7	2021	However, Ed NEIL1 was found to exhibit higher affinity for 5-OHU:G and 5-OHU:C duplexes than UE NEIL1.	5-ohu	71-76	nei like DNA glycosylase 1	Homo sapiens	12-17
33929180-7	2021	However, Ed NEIL1 was found to exhibit higher affinity for 5-OHU:G and 5-OHU:C duplexes than UE NEIL1.	5-ohu	71-76	nei like DNA glycosylase 1	Homo sapiens	96-101
33929180-8	2021	These results suggest that NEIL1 plays an important role in detecting and capturing 5-OHU lesions in inappropriate contexts, in a manner that does not lead to excision, to prevent mutations and strand breaks.	5-ohu	84-89	nei like DNA glycosylase 1	Homo sapiens	27-32
33929180-9	2021	Indeed, inefficient removal of 5-OHU by NEIL1 from 5-OHU:A base pairs formed during replication would thwart mutagenesis.	5-ohu	31-36	nei like DNA glycosylase 1	Homo sapiens	40-45
33929180-9	2021	Indeed, inefficient removal of 5-OHU by NEIL1 from 5-OHU:A base pairs formed during replication would thwart mutagenesis.	5-ohu	51-56	nei like DNA glycosylase 1	Homo sapiens	40-45
33929180-10	2021	Notably, nonproductive engagement of 5-OHU by Ed NEIL1 suggests the extent of 5-OHU repair will be reduced under cellular conditions, such as inflammation, that increase the extent of NEIL1 RNA editing.	5-ohu	37-42	nei like DNA glycosylase 1	Homo sapiens	49-54
33929180-10	2021	Notably, nonproductive engagement of 5-OHU by Ed NEIL1 suggests the extent of 5-OHU repair will be reduced under cellular conditions, such as inflammation, that increase the extent of NEIL1 RNA editing.	5-ohu	37-42	nei like DNA glycosylase 1	Homo sapiens	184-189
33929180-10	2021	Notably, nonproductive engagement of 5-OHU by Ed NEIL1 suggests the extent of 5-OHU repair will be reduced under cellular conditions, such as inflammation, that increase the extent of NEIL1 RNA editing.	5-ohu	78-83	nei like DNA glycosylase 1	Homo sapiens	49-54
33925271-0	2021	NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.	TH5487	96-102	nei like DNA glycosylase 1	Homo sapiens	0-5
33925271-7	2021	NEIL1 recruitment kinetics and chromatin binding after DNA damage induction increase in cells treated with OGG1 inhibitor TH5487 in a dose-dependent manner, whereas NEIL2 accumulation at DNA damage sites is prolonged following OGG1 inhibition.	TH5487	122-128	nei like DNA glycosylase 1	Homo sapiens	0-5
32302101-0	2020	Inhibition of Excison of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.	Hydantoins	47-56	nei like DNA glycosylase 1	Homo sapiens	72-77
33300026-7	2021	Intriguingly, from the evolutionarily conserved unstructured domain that targets NEIL1 to open chromatin, its damage surveillance of highly oxidation-susceptible sites to preserve essential gene function and to limit instability and cancer likely originated ~500 million years ago during the buildup of free atmospheric oxygen.	Oxygen	320-326	nei like DNA glycosylase 1	Homo sapiens	81-86
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	nei like DNA glycosylase 1	Homo sapiens	65-70
32302101-7	2020	The primary factor that recognizes DNA lesions is the DNA damage-sensing factor XPC-RAD23B (XPC), while the glycosylase NEIL1 is known to remove Gh and Sp lesions from double-stranded DNA.	spiroiminodihydantoin	152-154	nei like DNA glycosylase 1	Homo sapiens	120-125
32302101-8	2020	It is shown here that in aqueous solutions containing nanomolar concentrations of proteins, XPC and NEIL1 compete for binding to 147-mer oligonucleotide duplexes that contain single Gh or Sp lesions under conditions of [protein] >> [DNA] concentrations, thus inhibiting the rate of BER catalysed by NEIL1.	Oligonucleotides	137-152	nei like DNA glycosylase 1	Homo sapiens	100-105
32302101-8	2020	It is shown here that in aqueous solutions containing nanomolar concentrations of proteins, XPC and NEIL1 compete for binding to 147-mer oligonucleotide duplexes that contain single Gh or Sp lesions under conditions of [protein] >> [DNA] concentrations, thus inhibiting the rate of BER catalysed by NEIL1.	Oligonucleotides	137-152	nei like DNA glycosylase 1	Homo sapiens	299-304
32302101-12	2020	These slow kinetics are attributed to the dissociation of XPC-DNA complexes that allow for the rebinding of NEIL1 to the temporarily exposed Gh or Sp lesions, and the incisions observed under these steady-state conditions.	spiroiminodihydantoin	147-149	nei like DNA glycosylase 1	Homo sapiens	108-113
32069022-9	2020	However, binding affinity assessed using catalytically inactive variants of Fpg and NEIL1 indicated higher affinity for the 2"-F-riboGh containing duplexes.	Fluorine	124-128	nei like DNA glycosylase 1	Homo sapiens	84-89
31784740-7	2020	We have investigated the removal of 8-oxoguanine (8-oxoG) and 5,6-dihydrouracil (DHU) by Escherichia coli Fpg and Nei and human NEIL1 and NEIL2 from single-strand oligonucleotides, perfect duplexes, bubbles with different numbers of unpaired bases (6-30), bubbles containing the lesion in different positions and D-loops with the third strand made of DNA or RNA.	8-hydroxyguanine	36-48	nei like DNA glycosylase 1	Homo sapiens	128-133
31945542-10	2020	Unexpectedly, NEIL1 and NEIL3 were trapped following H2O2 treatment, but not detectably in cells exposed to CuOP.	Water	53-57	nei like DNA glycosylase 1	Homo sapiens	14-19
32069022-5	2020	The 2"-F-hydantoins in duplex DNA were found to be highly resistant to the glycosylase activity of Fpg and NEIL1 compared to the unmodified lesion substrates.	Hydantoins	4-19	nei like DNA glycosylase 1	Homo sapiens	107-112
32069022-8	2020	Fpg and NEIL1 showed high affinity for the 2"-F-Gh duplexes in both ribo and arabino configurations.	Fluorine	43-47	nei like DNA glycosylase 1	Homo sapiens	8-13
31784740-7	2020	We have investigated the removal of 8-oxoguanine (8-oxoG) and 5,6-dihydrouracil (DHU) by Escherichia coli Fpg and Nei and human NEIL1 and NEIL2 from single-strand oligonucleotides, perfect duplexes, bubbles with different numbers of unpaired bases (6-30), bubbles containing the lesion in different positions and D-loops with the third strand made of DNA or RNA.	8-hydroxyguanine	50-56	nei like DNA glycosylase 1	Homo sapiens	128-133
31784740-8	2020	Fpg, NEIL1 and NEIL2 efficiently excised lesions located within bubbles, with NEIL1 and NEIL2 being specific for DHU, and Fpg removing both 8-oxoG and DHU.	dihydrouracil	113-116	nei like DNA glycosylase 1	Homo sapiens	78-83
30716333-4	2019	Here we apply stopped-flow kinetics with detection of intrinsic Trp fluorescence and Forster resonance energy transfer fluorescence to follow the conformational dynamics of human NEIL1 and DNA when the enzyme interacts with undamaged DNA, or DNA containing cleavable or non-cleavable abasic sites, or dihydrouracil lesions.	dihydrouracil	301-314	nei like DNA glycosylase 1	Homo sapiens	179-184
31733589-1	2020	Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine.	Adenosine	51-60	nei like DNA glycosylase 1	Homo sapiens	24-29
31733589-1	2020	Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine.	Adenosine	100-109	nei like DNA glycosylase 1	Homo sapiens	24-29
31733589-1	2020	Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine.	Inosine	113-120	nei like DNA glycosylase 1	Homo sapiens	24-29
31733589-2	2020	Previous investigations of the catalytic efficiencies of the two forms of the enzyme revealed differential release of thymine glycol (ThyGly) from synthetic oligodeoxynucleotides, with the unedited form, NEIL1 K242 being  30-fold more efficient than the edited NEIL1 K242R.	thymine glycol	118-132	nei like DNA glycosylase 1	Homo sapiens	204-209
31733589-2	2020	Previous investigations of the catalytic efficiencies of the two forms of the enzyme revealed differential release of thymine glycol (ThyGly) from synthetic oligodeoxynucleotides, with the unedited form, NEIL1 K242 being  30-fold more efficient than the edited NEIL1 K242R.	thymine glycol	134-140	nei like DNA glycosylase 1	Homo sapiens	204-209
31733589-2	2020	Previous investigations of the catalytic efficiencies of the two forms of the enzyme revealed differential release of thymine glycol (ThyGly) from synthetic oligodeoxynucleotides, with the unedited form, NEIL1 K242 being  30-fold more efficient than the edited NEIL1 K242R.	thymine glycol	134-140	nei like DNA glycosylase 1	Homo sapiens	261-266
31733589-3	2020	In contrast, when these enzymes were reacted with oligodeoxynucleotides containing guanidinohydantoin or spiroiminohydantoin, the edited K242R form was  3-fold more efficient than the unedited NEIL1.	guanidinohydantoin	83-101	nei like DNA glycosylase 1	Homo sapiens	193-198
31733589-3	2020	In contrast, when these enzymes were reacted with oligodeoxynucleotides containing guanidinohydantoin or spiroiminohydantoin, the edited K242R form was  3-fold more efficient than the unedited NEIL1.	spiroiminohydantoin	105-124	nei like DNA glycosylase 1	Homo sapiens	193-198
31733589-6	2020	Of all the measured DNA lesions, imidazole ring-opened 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were preferentially released by both NEIL1 enzymes with K242R being  1.3 and 1.2-fold more efficient than K242 on excision of FapyAde and FapyGua, respectively.	imidazole	33-42	nei like DNA glycosylase 1	Homo sapiens	194-199
31733589-6	2020	Of all the measured DNA lesions, imidazole ring-opened 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were preferentially released by both NEIL1 enzymes with K242R being  1.3 and 1.2-fold more efficient than K242 on excision of FapyAde and FapyGua, respectively.	4,6-diamino-5-N-formamidopyrimidine	55-88	nei like DNA glycosylase 1	Homo sapiens	194-199
31733589-6	2020	Of all the measured DNA lesions, imidazole ring-opened 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were preferentially released by both NEIL1 enzymes with K242R being  1.3 and 1.2-fold more efficient than K242 on excision of FapyAde and FapyGua, respectively.	2,6-diamino-4-hydroxy-5-formamidopyrimidine	103-146	nei like DNA glycosylase 1	Homo sapiens	194-199
31733589-7	2020	Consistent with the prior literature, large differences ( 7.5 to 12-fold) were measured in the excision of ThyGly from genomic DNA by the unedited versus edited NEIL1.	thymine glycol	107-113	nei like DNA glycosylase 1	Homo sapiens	161-166
31733589-8	2020	In contrast, the edited NEIL1 was more efficient ( 3 to 5-fold) on release of 5-hydroxycytosine.	5-hydroxycytosine	78-95	nei like DNA glycosylase 1	Homo sapiens	24-29
31733589-9	2020	Excision kinetics on DNA containing a site-specific aflatoxin B1-FapyGua adduct revealed an  1.4-fold higher rate by the unedited NEIL1.	Aflatoxin B1	52-64	nei like DNA glycosylase 1	Homo sapiens	130-135
31415677-7	2019	There is also significant epistatic relationship (p = 0.0410) between UNG rs80001089 and NEIL1 rs7182283 in TC from LOAD subjects.	Technetium	108-110	nei like DNA glycosylase 1	Homo sapiens	89-94
30897375-9	2019	These data suggest that inactivating polymorphic variants of NEIL1 could be a potential driver of HCCs in aflatoxin-exposed populations.	Aflatoxins	106-115	nei like DNA glycosylase 1	Homo sapiens	61-66
31018584-4	2019	In this study, both human NEIL1 and NEIL3 have been expressed and purified from E. coli, and the DNA glycosylase activity of these two proteins confirmed using single- and double-stranded DNA oligonucleotide substrates containing the oxidative bases, 5-hydroxyuracil, 8-oxoguanine and thymine glycol.	Oligonucleotides	192-207	nei like DNA glycosylase 1	Homo sapiens	26-31
31018584-4	2019	In this study, both human NEIL1 and NEIL3 have been expressed and purified from E. coli, and the DNA glycosylase activity of these two proteins confirmed using single- and double-stranded DNA oligonucleotide substrates containing the oxidative bases, 5-hydroxyuracil, 8-oxoguanine and thymine glycol.	5-hydroxyuracil	251-266	nei like DNA glycosylase 1	Homo sapiens	26-31
31018584-4	2019	In this study, both human NEIL1 and NEIL3 have been expressed and purified from E. coli, and the DNA glycosylase activity of these two proteins confirmed using single- and double-stranded DNA oligonucleotide substrates containing the oxidative bases, 5-hydroxyuracil, 8-oxoguanine and thymine glycol.	8-hydroxyguanine	268-280	nei like DNA glycosylase 1	Homo sapiens	26-31
31018584-4	2019	In this study, both human NEIL1 and NEIL3 have been expressed and purified from E. coli, and the DNA glycosylase activity of these two proteins confirmed using single- and double-stranded DNA oligonucleotide substrates containing the oxidative bases, 5-hydroxyuracil, 8-oxoguanine and thymine glycol.	thymine glycol	285-299	nei like DNA glycosylase 1	Homo sapiens	26-31
30716333-5	2019	NEIL1 processed a natural abasic site and a damaged base in DNA equally well but showed an additional fluorescently discernible step when DHU was present, likely reflecting additional rearrangements during base eversion into the enzyme"s active site.	1,3-Dicyclohexylurea	138-141	nei like DNA glycosylase 1	Homo sapiens	0-5
30716333-6	2019	With undamaged DNA and DNA containing a non-cleavable abasic site analog, (3-hydroxytetrahydrofuran-2-yl)methyl phosphate, NEIL1 was diverted to a non-productive DNA conformation early in the reaction.	(3-hydroxytetrahydrofuran-2-yl)methyl phosphate	74-121	nei like DNA glycosylase 1	Homo sapiens	123-128
31024746-1	2019	In the present work, a thermodynamic analysis of the interaction between endonuclease VIII (Endo VIII) and model DNA substrates containing damaged nucleotides, such as 5,6-dihydrouridine and 2-hydroxymethyl-3-hydroxytetrahydrofuran (F-site), was performed.	5,6-dihydrouridine	168-186	nei like DNA glycosylase 1	Homo sapiens	73-90
31024746-1	2019	In the present work, a thermodynamic analysis of the interaction between endonuclease VIII (Endo VIII) and model DNA substrates containing damaged nucleotides, such as 5,6-dihydrouridine and 2-hydroxymethyl-3-hydroxytetrahydrofuran (F-site), was performed.	5,6-dihydrouridine	168-186	nei like DNA glycosylase 1	Homo sapiens	92-101
31024746-1	2019	In the present work, a thermodynamic analysis of the interaction between endonuclease VIII (Endo VIII) and model DNA substrates containing damaged nucleotides, such as 5,6-dihydrouridine and 2-hydroxymethyl-3-hydroxytetrahydrofuran (F-site), was performed.	2-hydroxymethyl-3-hydroxytetrahydrofuran	191-231	nei like DNA glycosylase 1	Homo sapiens	73-90
31024746-1	2019	In the present work, a thermodynamic analysis of the interaction between endonuclease VIII (Endo VIII) and model DNA substrates containing damaged nucleotides, such as 5,6-dihydrouridine and 2-hydroxymethyl-3-hydroxytetrahydrofuran (F-site), was performed.	2-hydroxymethyl-3-hydroxytetrahydrofuran	191-231	nei like DNA glycosylase 1	Homo sapiens	92-101
29234069-2	2017	Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-derived ICLs in three-stranded DNA via hydrolysis of the glycosidic bond between the crosslinked base and deoxyribose sugar.	deoxyribose sugar	219-236	nei like DNA glycosylase 1	Homo sapiens	82-87
30448017-7	2019	Product formation from the reaction of human NEIL1 with ds oligodeoxynucleotides containing a unique NM-Fapy-dG followed a bi-component exponential function under single turnover conditions.	ds oligodeoxynucleotides	56-80	nei like DNA glycosylase 1	Homo sapiens	45-50
30448017-7	2019	Product formation from the reaction of human NEIL1 with ds oligodeoxynucleotides containing a unique NM-Fapy-dG followed a bi-component exponential function under single turnover conditions.	nm-fapy-dg	101-111	nei like DNA glycosylase 1	Homo sapiens	45-50
29698889-5	2018	NEIL1 mutant having the substitution of Lys 296-298 with neutral Ala loses nuclear localization, whereas Lys &gt; Arg substitution (in 3KR mutant) at the same sites does not affect NEIL1"s nuclear localization or chromatin binding, presumably due to retention of the positive charge.	Lysine	40-43	nei like DNA glycosylase 1	Homo sapiens	0-5
29698889-5	2018	NEIL1 mutant having the substitution of Lys 296-298 with neutral Ala loses nuclear localization, whereas Lys &gt; Arg substitution (in 3KR mutant) at the same sites does not affect NEIL1"s nuclear localization or chromatin binding, presumably due to retention of the positive charge.	Alanine	65-68	nei like DNA glycosylase 1	Homo sapiens	0-5
29698889-11	2018	We thus conclude that the major role of acetylable Lys residues in NEIL1 is to stabilize the formation of chromatin-bound repair complexes which protect cells from oxidative stress.	Lysine	51-54	nei like DNA glycosylase 1	Homo sapiens	67-72
29061312-1	2017	BACKGROUND: In subjects who present a first fasting plasma glucose (FPG1) &gt;=7.0mmol/l without classic symptoms of diabetes, diagnosis of diabetes will likely be missed without an additional oral glucose tolerance test (OGTT) in the Chinese population.	Glucose	59-66	nei like DNA glycosylase 1	Homo sapiens	68-72
29061312-1	2017	BACKGROUND: In subjects who present a first fasting plasma glucose (FPG1) &gt;=7.0mmol/l without classic symptoms of diabetes, diagnosis of diabetes will likely be missed without an additional oral glucose tolerance test (OGTT) in the Chinese population.	Glucose	198-205	nei like DNA glycosylase 1	Homo sapiens	68-72
29156764-5	2017	Upon treatment with hydrogen peroxide, we observe increased levels of stalled replication forks in cells expressing G83D NEIL1 versus cells expressing the wild-type (WT) protein.	Hydrogen Peroxide	20-37	nei like DNA glycosylase 1	Homo sapiens	121-126
27354518-4	2016	Together with computational and biochemical analyses, our results suggest that NEIL1 promotes tautomerization of thymine glycol (Tg)-a preferred substrate-for optimal binding in its active site.	thymine glycol	113-127	nei like DNA glycosylase 1	Homo sapiens	79-84
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-carboxylcytosine	27-45	nei like DNA glycosylase 1	Homo sapiens	0-10
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-carboxylcytosine	27-45	nei like DNA glycosylase 1	Homo sapiens	12-17
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-formyl	83-91	nei like DNA glycosylase 1	Homo sapiens	0-10
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-formyl	83-91	nei like DNA glycosylase 1	Homo sapiens	12-17
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-carboxylcytosine	96-114	nei like DNA glycosylase 1	Homo sapiens	0-10
28827588-0	2017	Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.	5-carboxylcytosine	96-114	nei like DNA glycosylase 1	Homo sapiens	12-17
28827588-4	2017	However, this result has been disputed, and it was suggested instead that NEIL1 is recruited by the monofunctional TDG for the 2"-deoxyribose excision step.	Deoxyribose	127-141	nei like DNA glycosylase 1	Homo sapiens	74-79
27880870-8	2017	This review focuses on initiation of BER by the mammalian Nei-like1-3 (NEIL1-3) glycosylases for removal of 2Ih, Sp, and Gh.	spiroiminodihydantoin	113-115	nei like DNA glycosylase 1	Homo sapiens	71-76
27924031-3	2017	Interestingly, we have identified two enzymes that catalyse NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM26).	tripartite	123-133	nei like DNA glycosylase 1	Homo sapiens	60-65
27924031-4	2017	We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues.	Lysine	158-164	nei like DNA glycosylase 1	Homo sapiens	68-73
27924031-4	2017	We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues.	Lysine	158-164	nei like DNA glycosylase 1	Homo sapiens	125-130
28827588-6	2017	We confirm direct NEIL1 TDG binding and NEIL1 mediated 2"-deoxyribose excision downstream of TDG glycosylase activity.	Deoxyribose	55-69	nei like DNA glycosylase 1	Homo sapiens	40-45
27918552-9	2016	NEIL1 DNA glycosylase, involved in repair of oxidized nucleosides, was found to be significantly downregulated as a cellular response to MTH1-MYH co-suppression.	Nucleosides	54-65	nei like DNA glycosylase 1	Homo sapiens	0-5
27518429-2	2016	NEIL1 recognizes and cleaves mainly oxidized pyrimidines from DNA.	Pyrimidines	45-56	nei like DNA glycosylase 1	Homo sapiens	0-5
27518429-6	2016	We expressed, purified, and characterized phosphomimetic (glutamate) and phosphoablating (alanine) mutants of the three phosphorylation sites in NEIL1 revealed by the MS analysis.	Glutamic Acid	58-67	nei like DNA glycosylase 1	Homo sapiens	145-150
27518429-6	2016	We expressed, purified, and characterized phosphomimetic (glutamate) and phosphoablating (alanine) mutants of the three phosphorylation sites in NEIL1 revealed by the MS analysis.	Alanine	90-97	nei like DNA glycosylase 1	Homo sapiens	145-150
27354518-4	2016	Together with computational and biochemical analyses, our results suggest that NEIL1 promotes tautomerization of thymine glycol (Tg)-a preferred substrate-for optimal binding in its active site.	thymine glycol	129-131	nei like DNA glycosylase 1	Homo sapiens	79-84
26105778-10	2015	Interestingly, the use of the formamidopyrimidine glycosylase (FPG) protein and endonuclease VIII enables the detection of oxidized purine and pyrimidine bases, respectively.	purine	132-138	nei like DNA glycosylase 1	Homo sapiens	80-97
26751644-3	2016	Here we show that human NEIL1 and NEIL2 DNA glycosylases coordinate abasic-site processing during TET-TDG DNA demethylation.	tetramethylenedisulfotetramine	98-101	nei like DNA glycosylase 1	Homo sapiens	24-29
26751644-4	2016	NEIL1 and NEIL2 cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover.	Sugars	148-153	nei like DNA glycosylase 1	Homo sapiens	0-5
25813041-4	2015	Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none of the glycosylases, including OGG1, are able to remove 8-oxoG from telomeric quadruplexes.	Hydantoins	54-63	nei like DNA glycosylase 1	Homo sapiens	10-15
25813041-6	2015	However, NEIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats much more rapidly than the commonly studied four-repeat quadruplex structures.	Hydantoins	39-49	nei like DNA glycosylase 1	Homo sapiens	9-14
24382305-8	2014	Human NEIL1 is known to undergo editing whereby the lysine at position 242 is recoded into an arginine.	Lysine	52-58	nei like DNA glycosylase 1	Homo sapiens	6-11
24382305-8	2014	Human NEIL1 is known to undergo editing whereby the lysine at position 242 is recoded into an arginine.	Arginine	94-102	nei like DNA glycosylase 1	Homo sapiens	6-11