PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35063864-6	2022	We showed that COS significantly suppressed the abnormal expression of these genes, including ceramide glucosyltransferase (CGT), sphingolipid 4-desaturase (DEGS2), alkaline ceramidase (ACER1), sphingosine kinase 2 (SPHK2), lysophosphatidylcholine acyltransferase (LPCAT1), and aromatic-L-amino-acid (DDC).	carbonyl sulfide	15-18	sphingosine kinase 2	Mus musculus	194-214
34607257-2	2021	Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases therapy.	Glucose	43-50	sphingosine kinase 2	Mus musculus	27-32
34399014-0	2021	Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.	Cuprizone	62-71	sphingosine kinase 2	Mus musculus	0-20
34399014-9	2021	Levels of cytotoxic sphingosine and ceramide were higher in the corpus callosum of SphK2-/- mice, and in contrast to WT mice, did not decline following cuprizone withdrawal in SphK2-/- mice.	Sphingosine	20-31	sphingosine kinase 2	Mus musculus	83-88
34399014-9	2021	Levels of cytotoxic sphingosine and ceramide were higher in the corpus callosum of SphK2-/- mice, and in contrast to WT mice, did not decline following cuprizone withdrawal in SphK2-/- mice.	Ceramides	36-44	sphingosine kinase 2	Mus musculus	83-88
34399014-12	2021	We propose that persistently high levels of sphingosine and ceramide, a direct consequence of SphK2 deficiency, may block remyelination.	Sphingosine	44-55	sphingosine kinase 2	Mus musculus	94-99
34399014-12	2021	We propose that persistently high levels of sphingosine and ceramide, a direct consequence of SphK2 deficiency, may block remyelination.	Ceramides	60-68	sphingosine kinase 2	Mus musculus	94-99
34789044-0	2021	The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways.	Sphingosine	16-27	sphingosine kinase 2	Mus musculus	133-153
35063864-6	2022	We showed that COS significantly suppressed the abnormal expression of these genes, including ceramide glucosyltransferase (CGT), sphingolipid 4-desaturase (DEGS2), alkaline ceramidase (ACER1), sphingosine kinase 2 (SPHK2), lysophosphatidylcholine acyltransferase (LPCAT1), and aromatic-L-amino-acid (DDC).	carbonyl sulfide	15-18	sphingosine kinase 2	Mus musculus	216-221
34015468-7	2021	These Sphk2-kd cells accumulated sphingosine as a consequence of the knockdown, and showed enhanced nephrin and WT1 mRNA and protein expressions similar to the finding in Sphk2 knockout mice.	Sphingosine	33-44	sphingosine kinase 2	Mus musculus	6-11
34015468-0	2021	Loss of sphingosine kinase 2 enhances Wilm"s tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.	Streptozocin	123-137	sphingosine kinase 2	Mus musculus	8-28
34015468-4	2021	We show that streptozotocin (STZ)-induced nephropathy and albuminuria in mice is prevented by genetic depletion of Sphk2.	Streptozocin	13-27	sphingosine kinase 2	Mus musculus	115-120
34015468-4	2021	We show that streptozotocin (STZ)-induced nephropathy and albuminuria in mice is prevented by genetic depletion of Sphk2.	Streptozocin	29-32	sphingosine kinase 2	Mus musculus	115-120
34054552-8	2021	Furthermore, Sal remarkably eradicated the influence of SphK1, SphK2, S1P, and S1PRs triggered by CCl4, whether stimulating or hindering.	rhodioloside	13-16	sphingosine kinase 2	Mus musculus	63-68
34015468-8	2021	Treatment of wildtype podocytes with the highly selective Sphk2 inhibitor SLM6031434 caused a similar upregulation of nephrin and WT1 expression.	slm6031434	74-84	sphingosine kinase 2	Mus musculus	58-63
34015468-11	2021	Mechanistically, the protection by Sphk2-kd may depend on accumulated sphingosine and inhibited PKC activity, since treatment of cells with exogenous sphingosine not only reduced the phosphorylation pattern of PKC substrates, but also increased WT1 protein expression.	Sphingosine	70-81	sphingosine kinase 2	Mus musculus	35-40
34015468-11	2021	Mechanistically, the protection by Sphk2-kd may depend on accumulated sphingosine and inhibited PKC activity, since treatment of cells with exogenous sphingosine not only reduced the phosphorylation pattern of PKC substrates, but also increased WT1 protein expression.	Sphingosine	150-161	sphingosine kinase 2	Mus musculus	35-40
34015468-13	2021	The glucocorticoid dexamethasone, which is a treatment option in many glomerular diseases and is known to mediate a nephroprotection, not only downregulated Sphk2 and enhanced cellular sphingosine, but also enhanced WT1 and nephrin expressions, thus, suggesting that parts of the nephroprotective effect of dexamethasone is mediated by Sphk2 downregulation.	Dexamethasone	19-32	sphingosine kinase 2	Mus musculus	157-162
34015468-13	2021	The glucocorticoid dexamethasone, which is a treatment option in many glomerular diseases and is known to mediate a nephroprotection, not only downregulated Sphk2 and enhanced cellular sphingosine, but also enhanced WT1 and nephrin expressions, thus, suggesting that parts of the nephroprotective effect of dexamethasone is mediated by Sphk2 downregulation.	Dexamethasone	19-32	sphingosine kinase 2	Mus musculus	336-341
32966847-0	2020	A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy.	tat-peptide	33-44	sphingosine kinase 2	Mus musculus	2-22
33301900-0	2021	Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.	slm6031434	63-73	sphingosine kinase 2	Mus musculus	31-51
33566377-5	2021	Whereas GalN/LPS treatment-induced hepatic activation of NF-kappaB and JNK in wild-type and SphK2-/- mice, these signaling pathways were reduced in SphK1-/- mice.	Galactosamine	8-12	sphingosine kinase 2	Mus musculus	92-97
33171607-0	2020	A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naive CD4 T Lymphocytes.	Imiquimod	87-96	sphingosine kinase 2	Mus musculus	18-38
33171607-1	2020	Sphingosine kinases (SK) catalyze the phosphorylation of sphingosine to generate sphingosine-1-phosphate.	Sphingosine	57-68	sphingosine kinase 2	Mus musculus	21-23
33171607-1	2020	Sphingosine kinases (SK) catalyze the phosphorylation of sphingosine to generate sphingosine-1-phosphate.	sphingosine 1-phosphate	81-104	sphingosine kinase 2	Mus musculus	21-23
33171607-3	2020	Previously, we showed the beneficial effects of SK2 inhibition, using ABC294640, in a psoriasis mouse model.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	70-79	sphingosine kinase 2	Mus musculus	48-51
32966847-3	2020	Mice were administered with TAT-SPK2 by intraperitoneal injection before or after transient middle cerebral artery occlusion (tMCAO).	tmcao	126-131	sphingosine kinase 2	Mus musculus	32-36
32966847-8	2020	In the tMCAO model, pre-treatment with TAT-SPK2 significantly reduced infarct volume, improved neurological function and decreased brain edema.	tmcao	7-12	sphingosine kinase 2	Mus musculus	43-47
32521763-3	2020	Using high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS), we observed a marked accumulation of lipids containing a di-unsaturated sphingadiene base in the hippocampus of mice lacking the metabolic enzyme sphingosine kinase 2 (SphK2).	di-unsaturated sphingadiene	138-165	sphingosine kinase 2	Mus musculus	227-247
32917816-3	2020	Hepatocyte-specific Sphk2 knockout mice exhibit pronounced insulin resistance and glucose intolerance.	Glucose	82-89	sphingosine kinase 2	Mus musculus	20-25
32917816-4	2020	Likewise, SphK2-deficient hepatocytes are resistant to insulin-induced activation of the phosphoinositide 3-kinase (PI3K)-Akt-FoxO1 pathway and elevated hepatic glucose production.	Glucose	161-168	sphingosine kinase 2	Mus musculus	10-15
32917816-5	2020	Mechanistically, SphK2 deficiency leads to the accumulation of sphingosine that, in turn, suppresses hepatic insulin signaling by inhibiting PI3K activation in hepatocytes.	Sphingosine	63-74	sphingosine kinase 2	Mus musculus	17-22
32917816-6	2020	Either reexpressing functional SphK2 or pharmacologically inhibiting sphingosine production restores insulin sensitivity in SphK2-deficient hepatocytes.	Sphingosine	69-80	sphingosine kinase 2	Mus musculus	124-129
32546724-5	2020	Assays of ChIP-Seq and luciferase reporter gene demonstrated that high SphK2 upregulated DPD through promoting the HDAC1-mediated H3K56ac, leading to the degradation of intracellular 5-FU into inactive alpha-fluoro-beta-alanine (FBAL).	Fluorouracil	183-187	sphingosine kinase 2	Mus musculus	71-76
32546724-6	2020	Lastly, inhibition of SphK2 by SLR080811 exhibited excellent inhibition on DPD expression and potently reversed 5-FU resistance in colorectal tumors of villin-SphK2 Tg mice.	Fluorouracil	112-116	sphingosine kinase 2	Mus musculus	22-27
32546724-7	2020	Overall, this study manifests that SphK2high conferred 5-FU resistance through upregulating tumoral DPD, which highlights the strategies of blocking SphK2 to overcome 5-FU resistance in CRC.	Fluorouracil	55-59	sphingosine kinase 2	Mus musculus	35-40
32546724-7	2020	Overall, this study manifests that SphK2high conferred 5-FU resistance through upregulating tumoral DPD, which highlights the strategies of blocking SphK2 to overcome 5-FU resistance in CRC.	Fluorouracil	167-171	sphingosine kinase 2	Mus musculus	35-40
32546724-7	2020	Overall, this study manifests that SphK2high conferred 5-FU resistance through upregulating tumoral DPD, which highlights the strategies of blocking SphK2 to overcome 5-FU resistance in CRC.	Fluorouracil	167-171	sphingosine kinase 2	Mus musculus	149-154
32998447-1	2020	We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage.	sphingosine 1-phosphate	19-42	sphingosine kinase 2	Mus musculus	62-82
32998447-1	2020	We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage.	sphingosine 1-phosphate	19-42	sphingosine kinase 2	Mus musculus	84-87
32521763-5	2020	Phosphorylation of sphingoid bases by sphingosine kinase 1 (SphK1) or SphK2 forms the penultimate step in the lysosomal catabolism of all sphingolipids.	sphingoid bases	19-34	sphingosine kinase 2	Mus musculus	70-75
32521763-5	2020	Phosphorylation of sphingoid bases by sphingosine kinase 1 (SphK1) or SphK2 forms the penultimate step in the lysosomal catabolism of all sphingolipids.	Sphingolipids	138-151	sphingosine kinase 2	Mus musculus	70-75
32521763-6	2020	Both SphK1 and SphK2 phosphorylated sphinga-4,14-diene as efficiently as sphingosine, however deuterated tracer experiments in an oligodendrocyte cell line demonstrated that ceramides with a sphingosine base are more rapidly metabolized than those with a sphingadiene base.	sphinga-4,14-diene	36-54	sphingosine kinase 2	Mus musculus	15-20
32521763-7	2020	Since SphK2 is the dominant sphingosine kinase in brain, we propose that the accumulation of sphingadiene-based lipids in SphK2-deficient brains results from the slower catabolism of these lipids, combined with a bottleneck in the catabolic pathway created by the absence of SphK2.	sphingadiene	93-105	sphingosine kinase 2	Mus musculus	6-11
32521763-7	2020	Since SphK2 is the dominant sphingosine kinase in brain, we propose that the accumulation of sphingadiene-based lipids in SphK2-deficient brains results from the slower catabolism of these lipids, combined with a bottleneck in the catabolic pathway created by the absence of SphK2.	sphingadiene	93-105	sphingosine kinase 2	Mus musculus	122-127
32521763-7	2020	Since SphK2 is the dominant sphingosine kinase in brain, we propose that the accumulation of sphingadiene-based lipids in SphK2-deficient brains results from the slower catabolism of these lipids, combined with a bottleneck in the catabolic pathway created by the absence of SphK2.	sphingadiene	93-105	sphingosine kinase 2	Mus musculus	122-127
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	Sphingolipids	67-79	sphingosine kinase 2	Mus musculus	0-20
32546724-0	2020	SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulating H3K56ac-mediated DPD expression.	Fluorouracil	14-28	sphingosine kinase 2	Mus musculus	0-5
32393187-1	2020	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2).	sphingosine 1-phosphate	12-35	sphingosine kinase 2	Mus musculus	132-137
32393187-1	2020	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2).	Sphingolipids	71-84	sphingosine kinase 2	Mus musculus	132-137
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Sphingosine	20-31	sphingosine kinase 2	Mus musculus	51-56
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Ceramides	89-97	sphingosine kinase 2	Mus musculus	51-56
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Sphingosine	106-117	sphingosine kinase 2	Mus musculus	51-56
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	Sphingolipids	67-79	sphingosine kinase 2	Mus musculus	22-27
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	103-126	sphingosine kinase 2	Mus musculus	0-20
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	103-126	sphingosine kinase 2	Mus musculus	22-27
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	128-131	sphingosine kinase 2	Mus musculus	0-20
32017264-1	2020	Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	128-131	sphingosine kinase 2	Mus musculus	22-27
31797978-0	2019	Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation.	Cholesterol	41-52	sphingosine kinase 2	Mus musculus	0-20
31797978-5	2019	In macrophages, deficiency of SphK2, a major SphK isoform in this cell type, results in increases in cellular sphingosine and ceramides.	Sphingosine	110-121	sphingosine kinase 2	Mus musculus	30-35
31797978-5	2019	In macrophages, deficiency of SphK2, a major SphK isoform in this cell type, results in increases in cellular sphingosine and ceramides.	Ceramides	126-135	sphingosine kinase 2	Mus musculus	30-35
30997640-1	2019	Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	73-78
31641049-1	2019	Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	122-142
31641049-1	2019	Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	144-147
31641049-1	2019	Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain.	sphingosine 1-phosphate	25-28	sphingosine kinase 2	Mus musculus	122-142
31641049-1	2019	Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain.	sphingosine 1-phosphate	25-28	sphingosine kinase 2	Mus musculus	144-147
31641049-7	2019	Inhibition of the endosomal cholesterol exporter NPC1 greatly reduced sphingosine phosphorylation in glial cells, linking loss of SK2 activity and S1P in AD to perturbed endosomal lipid metabolism.	Cholesterol	28-39	sphingosine kinase 2	Mus musculus	130-133
31063660-7	2019	H19 deficiency protects mice from BDL-induced cholangiocyte proliferation and LF by inhibiting bile-acid-induced expression and activation of S1PR2 and sphingosine kinase 2 (SphK2).	Bile Acids and Salts	95-104	sphingosine kinase 2	Mus musculus	152-172
31063660-7	2019	H19 deficiency protects mice from BDL-induced cholangiocyte proliferation and LF by inhibiting bile-acid-induced expression and activation of S1PR2 and sphingosine kinase 2 (SphK2).	Bile Acids and Salts	95-104	sphingosine kinase 2	Mus musculus	174-179
31003959-4	2019	In the current study, we demonstrate that compared to wild-type (WT) mice, SphK2 deficient (SphK2-/-) mice exhibited a greater degree of liver injury and hepatic lipid accumulation after feeding with an alcohol diet for 60 days.	Alcohols	203-210	sphingosine kinase 2	Mus musculus	75-80
31003959-4	2019	In the current study, we demonstrate that compared to wild-type (WT) mice, SphK2 deficient (SphK2-/-) mice exhibited a greater degree of liver injury and hepatic lipid accumulation after feeding with an alcohol diet for 60 days.	Alcohols	203-210	sphingosine kinase 2	Mus musculus	92-97
31003959-6	2019	In vitro experiments showed that alcohol induced SphK2 expression in mouse primary hepatocytes and cultured mouse macrophages.	Alcohols	33-40	sphingosine kinase 2	Mus musculus	49-54
31003959-7	2019	Furthermore, alcohol feeding induced a more severe intestinal barrier dysfunction in SphK2-/- mice than WT mice.	Alcohols	13-20	sphingosine kinase 2	Mus musculus	85-90
31171507-6	2019	Isolated global Sphk2 deficiency was associated with thrombocytopenia, but this was not replicated by MK-restricted Sphk2 deletion and was reversed by compound deletion of either Sphk1 or S1pr2, suggesting that this phenotype arises from increased S1P export and S1P2 activation secondary to redistribution of sphingosine to Sphk1.	Sphingosine	310-321	sphingosine kinase 2	Mus musculus	16-21
31110049-3	2019	FTY720/fingolimod, a prodrug for the treatment of multiple sclerosis, is phosphorylated in vivo to its active phosphorylated form by sphingosine kinase 2 and has been shown to interfere with the actions of S1P and to inhibit ceramide biosynthesis.	Ceramides	225-233	sphingosine kinase 2	Mus musculus	133-153
31123291-0	2019	Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage.	Fingolimod Hydrochloride	40-46	sphingosine kinase 2	Mus musculus	0-20
30840833-3	2019	Sphingosine-1-phosphate, a bioactive sphingolipid metabolite, is produced by 2 highly conserved isoenzymes, sphingosine kinase (SphK) 1 and SphK2, and regulates diverse processes important for immune responses and autoimmunity.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	140-145
30840833-9	2019	Moreover, although absence of SphK2 increased pDC frequency in pristane-induced lupus, there were no major changes in their activation status.	pristane	63-71	sphingosine kinase 2	Mus musculus	30-35
31123291-6	2019	Additionally, FTY720 treatment protected Sphk2 KO retinas from light-induced damage despite significant retardation of FTY720 phosphorylation in Sphk2 KO mice.	Fingolimod Hydrochloride	14-20	sphingosine kinase 2	Mus musculus	41-46
31123291-6	2019	Additionally, FTY720 treatment protected Sphk2 KO retinas from light-induced damage despite significant retardation of FTY720 phosphorylation in Sphk2 KO mice.	Fingolimod Hydrochloride	14-20	sphingosine kinase 2	Mus musculus	145-150
30452878-4	2019	Exposure of beta-cells to palmitatic acid (PA), a saturated free fatty acid, resulted in a nearly 2-fold increase in SK2 expression, which paralleled the induction of cell death in a similar dose- and time-dependent fashion.	palmitatic acid	26-41	sphingosine kinase 2	Mus musculus	117-120
31064103-6	2019	Hepatic lipid droplets and triglyceride (TG) levels were also reduced by ONE due to upregulation of fatty acid oxidizing genes such as carnithine palmitoyltransferase (CPT1) and peroxisomal proliferator activated receptor alpha(PPARalpha) mediated by induction of sphingosine kinase 2 (SPHK2).	Triglycerides	41-43	sphingosine kinase 2	Mus musculus	264-284
31064103-6	2019	Hepatic lipid droplets and triglyceride (TG) levels were also reduced by ONE due to upregulation of fatty acid oxidizing genes such as carnithine palmitoyltransferase (CPT1) and peroxisomal proliferator activated receptor alpha(PPARalpha) mediated by induction of sphingosine kinase 2 (SPHK2).	Triglycerides	41-43	sphingosine kinase 2	Mus musculus	286-291
31064103-6	2019	Hepatic lipid droplets and triglyceride (TG) levels were also reduced by ONE due to upregulation of fatty acid oxidizing genes such as carnithine palmitoyltransferase (CPT1) and peroxisomal proliferator activated receptor alpha(PPARalpha) mediated by induction of sphingosine kinase 2 (SPHK2).	Fatty Acids	100-110	sphingosine kinase 2	Mus musculus	264-284
31064103-6	2019	Hepatic lipid droplets and triglyceride (TG) levels were also reduced by ONE due to upregulation of fatty acid oxidizing genes such as carnithine palmitoyltransferase (CPT1) and peroxisomal proliferator activated receptor alpha(PPARalpha) mediated by induction of sphingosine kinase 2 (SPHK2).	Fatty Acids	100-110	sphingosine kinase 2	Mus musculus	286-291
31064103-9	2019	Collectively, these results suggest that fermented ONE can activate fatty acid oxidation via SPHK2 in the liver.	Fatty Acids	68-78	sphingosine kinase 2	Mus musculus	93-98
30834454-0	2019	Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naive CD4 T Lymphocytes in Mice.	sphingosine 1-phosphate	40-63	sphingosine kinase 2	Mus musculus	11-31
30834454-6	2019	Inhibition of sphingosine kinase 2, but not sphingosine kinase 1, diminished levels of suppressor of cytokine signalling 1 and blocked T helper type 17 differentiation of naive CD4+ T cells; imiquimod-induced psoriasis-like skin symptoms were also ameliorated.	Imiquimod	191-200	sphingosine kinase 2	Mus musculus	14-34
30593892-3	2019	To obtain a better understanding of the role of Sphk2 in glucose and lipid metabolism, we have characterized 20- and 52-week old Sphk2-/- mice using glucose and insulin tolerance tests and by analyzing metabolic gene expression in adipose tissue.	Glucose	57-64	sphingosine kinase 2	Mus musculus	48-53
30593892-5	2019	Specifically, we found that 52-week old male Sphk2-/- mice had decreased weight and fat mass, and increased glucose tolerance and insulin sensitivity compared to control mice.	Glucose	108-115	sphingosine kinase 2	Mus musculus	45-50
30593892-11	2019	The beneficial metabolic effects observed in aged Sphk2-/- mice may be in part due to enhanced lipolysis by Atgl and increased levels of adiponectin, which has lipid- and glucose-lowering effects.	Glucose	171-178	sphingosine kinase 2	Mus musculus	50-55
30963819-1	2019	Background: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphKs), SphK1 and SphK2, is involved in inflammation.	sphingosine 1-phosphate	43-66	sphingosine kinase 2	Mus musculus	212-217
30452878-4	2019	Exposure of beta-cells to palmitatic acid (PA), a saturated free fatty acid, resulted in a nearly 2-fold increase in SK2 expression, which paralleled the induction of cell death in a similar dose- and time-dependent fashion.	Protactinium	43-45	sphingosine kinase 2	Mus musculus	117-120
30452878-5	2019	Silencing SK2 expression by its specific small interfering RNAs significantly inhibited PA-induced cell death and caspase-3 activation, whereas overexpression of SK2 promoted lipotoxicity in beta-cells.	Protactinium	88-90	sphingosine kinase 2	Mus musculus	10-13
30452878-6	2019	Mechanistically, upon exposure to PA, endogenous SK2 was shuttled from the nucleus to the cytoplasm, where it interacted with B-cell lymphoma-extra-large (Bcl-xL), leading to mitochondrial apoptotic pathway activation and cell death.	Protactinium	34-36	sphingosine kinase 2	Mus musculus	49-52
30452878-8	2019	Furthermore, SK2 deficiency in mice significantly prevented the loss of beta-cell mass, preserved insulin production, and ameliorated the diabetic phenotype in an established T2DM model induced by feeding a high-fat diet accompanied by administration of streptozotocin.	Streptozocin	254-268	sphingosine kinase 2	Mus musculus	13-16
30229580-7	2018	Knockdown of SphK2 using small interfering RNA induced mitochondrial dysfunction, decreased glucose-stimulated insulin secretion (GSIS), and reduced the expression of PHB, an essential regulator of mitochondrial metabolism.	Glucose	92-99	sphingosine kinase 2	Mus musculus	13-18
31416077-3	2019	S1P is produced by the phosphorylation of sphingosine catalyzed by sphingosine kinases (SphK1 and SphK2).	Sphingosine	42-53	sphingosine kinase 2	Mus musculus	98-103
30619336-14	2018	When exposed to EVs derived from cells treated with palmitate in the presence of a pharmacologic inhibitor of sphingosine kinases 1 and 2, macrophages displayed diminished chemotactic behavior.	Palmitates	52-61	sphingosine kinase 2	Mus musculus	110-137
30619336-17	2018	Conclusions:Palmitate-induced lipotoxic EVs are enriched in S1P through sphingosine kinases 1 and 2.	Palmitates	12-21	sphingosine kinase 2	Mus musculus	72-99
30463717-2	2018	Sphingosine-1-phosphate (S1P), a bioactive lipid mediator produced by sphingosine kinases (SphK1 and SphK2), plays a critical role in progression of many types of cancer.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	101-106
30613286-5	2018	Results: Inhibition of SphK2, which increased the blood S1P, resulted in the elevation of both arterial and venous sO2 in the hypoxic mouse brain, while the cerebral blood flow remained unchanged.	Sulfur Dioxide	115-118	sphingosine kinase 2	Mus musculus	23-28
30613286-7	2018	Furthermore, pre-treatment of the mice subject to tMCAO with the SphK2 inhibitor led to decreased infarct volume, improved motor function, and reduced neurological deficit, compared to the control treatment with a less potent R-enantiomer.	tmcao	50-55	sphingosine kinase 2	Mus musculus	65-70
30701020-7	2018	Furthermore, reciprocity in the regulation of sphingosine kinase 1 (Sphk1) and sphingosine kinase 2 (Sphk2) during PKCdelta independent ceramide generation was also observed during cisplatin treatment.	Ceramides	136-144	sphingosine kinase 2	Mus musculus	79-99
30701020-7	2018	Furthermore, reciprocity in the regulation of sphingosine kinase 1 (Sphk1) and sphingosine kinase 2 (Sphk2) during PKCdelta independent ceramide generation was also observed during cisplatin treatment.	Ceramides	136-144	sphingosine kinase 2	Mus musculus	101-106
30701020-7	2018	Furthermore, reciprocity in the regulation of sphingosine kinase 1 (Sphk1) and sphingosine kinase 2 (Sphk2) during PKCdelta independent ceramide generation was also observed during cisplatin treatment.	Cisplatin	181-190	sphingosine kinase 2	Mus musculus	79-99
30701020-7	2018	Furthermore, reciprocity in the regulation of sphingosine kinase 1 (Sphk1) and sphingosine kinase 2 (Sphk2) during PKCdelta independent ceramide generation was also observed during cisplatin treatment.	Cisplatin	181-190	sphingosine kinase 2	Mus musculus	101-106
30563056-3	2018	In this study, we characterize two sphingosine kinases (SPHK1 and SPHK2), which phosphorylate sphingosine to S1P, and three S1P receptors (S1PR1, S1PR2 and S1PR3) in mouse and rat eyes.	Sphingosine	35-46	sphingosine kinase 2	Mus musculus	66-71
30344931-0	2018	Correction: Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells.	sphingosine 1-phosphate	121-144	sphingosine kinase 2	Mus musculus	54-74
29518138-1	2018	Sphingosine Kinase-2 (Sphk2) is responsible for the production of the bioactive lipid Sphingosine-1 Phosphate, a key regulator of tissue repair.	sphingosine 1-phosphate	86-109	sphingosine kinase 2	Mus musculus	0-20
29673590-1	2018	Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	93-96
29673590-1	2018	Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	101-104
29518138-1	2018	Sphingosine Kinase-2 (Sphk2) is responsible for the production of the bioactive lipid Sphingosine-1 Phosphate, a key regulator of tissue repair.	sphingosine 1-phosphate	86-109	sphingosine kinase 2	Mus musculus	22-27
29392309-2	2018	Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes, including cell survival, proliferation, inflammation, migration, and angiogenesis.	sphingosine 1-phosphate	10-33	sphingosine kinase 2	Mus musculus	88-93
28807595-5	2017	More important, these changes were associated with increased expression of the antifibrotic protein Smad7 and higher levels of sphingosine in Sphk2-/- UUO kidneys.	Sphingosine	127-138	sphingosine kinase 2	Mus musculus	142-147
29285771-6	2018	Sphk2 expression was strongly reduced in MBMV together with an up-regulation of lipid phosphate and S1P phosphatases, resulting in a net decrease in S1P levels despite a compensatory increase in Sphk1 expression.	lipid phosphate	80-95	sphingosine kinase 2	Mus musculus	0-5
28911865-1	2017	3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) is identified as a selective SphK2 inhibitor.	3-(2-aminoethyl)-5-(3-(4-butoxylphenyl)propylidene)thiazolidine-2,4-dione	0-77	sphingosine kinase 2	Mus musculus	114-119
28911865-1	2017	3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) is identified as a selective SphK2 inhibitor.	K145	79-83	sphingosine kinase 2	Mus musculus	114-119
29109103-10	2017	Transcriptional analysis revealed 4 important genes involved in sphingolipid metabolism to be deregulated in HNF1A deficiency: Ormdl1, sphingosine kinase-2, neutral ceramidase, and ceramide synthase-5.	Sphingolipids	64-76	sphingosine kinase 2	Mus musculus	135-155
25808625-4	2015	Sphk2, a major isotype of sphingosine kinase in the liver, was transcriptionally up-regulated by tunicamycin and lipopolysaccharides.	Tunicamycin	97-108	sphingosine kinase 2	Mus musculus	0-5
28082351-3	2017	In this study, administration of clinically relevant doses of FTY720 to mice increased expression of NPC1 and -2 in brain and liver and decreased cholesterol in an SphK2-dependent manner.	Cholesterol	146-157	sphingosine kinase 2	Mus musculus	164-169
26822263-1	2016	OBJECTIVE: A key mediator of vascular EC barrier integrity, S1P, is derived from phosphorylation of sphingosine by the SK-1 and SK-2.	Sphingosine	100-111	sphingosine kinase 2	Mus musculus	128-132
26494858-0	2015	The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	35-44	sphingosine kinase 2	Mus musculus	4-24
26494858-0	2015	The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.	dihydroceramide	120-136	sphingosine kinase 2	Mus musculus	4-24
28614788-10	2017	In addition, we demonstrated that apelin controls the secretion of the lipid mediator sphingosine-1-phosphate in lymphatic endothelial cells by regulating the level of expression of sphingosine kinase 2 and the transporter SPNS2.	sphingosine 1-phosphate	86-109	sphingosine kinase 2	Mus musculus	182-202
28175299-5	2017	Sphingosine kinases 1 (SK1) and 2 (SK2) synthesize sphingosine-1-phosphate (S1P), a bioactive lipid messenger critically involved in many vital cellular processes, such as cell survival.	sphingosine 1-phosphate	51-74	sphingosine kinase 2	Mus musculus	35-38
28175299-12	2017	ABC294640, an inhibitor of SK2, reduces DNA damage in neurons and increases survival in two neuron models of HD.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	0-9	sphingosine kinase 2	Mus musculus	27-30
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	Sphingosine	35-46	sphingosine kinase 2	Mus musculus	73-78
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	sphingosine 1-phosphate	124-147	sphingosine kinase 2	Mus musculus	73-78
27799486-3	2017	We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury.	Folic Acid	179-189	sphingosine kinase 2	Mus musculus	73-78
27696512-7	2017	S1P levels and expression of SphK1, SphK2, and S1P receptors (S1PR1/S1PR3) were significantly elevated in DEN-treated mice.	Diethylnitrosamine	106-109	sphingosine kinase 2	Mus musculus	36-41
26808312-10	2016	Thus, ST-968 is a promising novel immunomodulatory compound that may be a valuable alternative to FTY720 under conditions where SK-2 activity is limited.	7a-(4-octylphenethyl)tetrahydro-1H-oxazolo(3,4-c)oxazole	6-12	sphingosine kinase 2	Mus musculus	128-132
26905748-6	2016	In cells over-expressing Sphk2, accumulation of Sa1P in the nuclear compartment inhibits histone deacetylase (HDAC) activity, causing increased acetylation of histone lysine residues.	Lysine	167-173	sphingosine kinase 2	Mus musculus	25-30
26905748-9	2016	Treatment of LM/Bc MEFs with a selective Sphk1 inhibitor, PF-543, or with ABC294640, a selective Sphk2 inhibitor, significantly reduced nuclear Sa1P accumulation after FB1, although Sa1P levels remained significantly increased relative to basal levels.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	74-83	sphingosine kinase 2	Mus musculus	97-102
26719367-3	2016	Sphingosine kinases (Sphk1, Sphk2) phosphorylate FTY720 in vivo to form the bioactive metabolite FTY720-1-phosphate (FTY720-P).	fty720-1-phosphate	97-115	sphingosine kinase 2	Mus musculus	28-33
26719367-3	2016	Sphingosine kinases (Sphk1, Sphk2) phosphorylate FTY720 in vivo to form the bioactive metabolite FTY720-1-phosphate (FTY720-P).	Fingolimod Hydrochloride	49-55	sphingosine kinase 2	Mus musculus	28-33
26719367-7	2016	Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus.	Fingolimod Hydrochloride	29-35	sphingosine kinase 2	Mus musculus	52-57
26719367-7	2016	Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	69-78	sphingosine kinase 2	Mus musculus	52-57
26719367-7	2016	Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus.	FTY 720P	116-124	sphingosine kinase 2	Mus musculus	52-57
26254847-8	2016	Mechanistically, hepatocyte exosomes directly fuse with target hepatocytes and transfer neutral ceramidase and sphingosine kinase 2 (SK2) causing increased synthesis of sphingosine-1-phosphate (S1P) within target hepatocytes.	sphingosine 1-phosphate	169-192	sphingosine kinase 2	Mus musculus	111-131
26254847-8	2016	Mechanistically, hepatocyte exosomes directly fuse with target hepatocytes and transfer neutral ceramidase and sphingosine kinase 2 (SK2) causing increased synthesis of sphingosine-1-phosphate (S1P) within target hepatocytes.	sphingosine 1-phosphate	169-192	sphingosine kinase 2	Mus musculus	133-136
26283908-7	2015	In the formalin model of acute peripheral inflammatory pain, Sphk2(-/-) mice showed facilitation of nociceptive transmission during the late response, whereas responses to early acute pain, and the number of c-Fos immunoreactive dorsal horn neurons were not different between Sphk2(-/-) and wild-type mice.	Formaldehyde	7-15	sphingosine kinase 2	Mus musculus	61-66
25808625-6	2015	In primary hepatocytes, adenoviral Sphk2 expression elevated cellular sphingosine 1 phosphate (S1P) and activated protein kinase B phosphorylation, with no alteration of insulin receptor substrate phosphorylation.	sphingosine 1-phosphate	70-93	sphingosine kinase 2	Mus musculus	35-40
25808625-7	2015	Hepatic overexpression of Sphk2 in mice fed a high-fat diet (HFD) led to elevated S1P and reduced ceramide, sphingomyelin, and glucosylceramide in plasma and liver.	Ceramides	98-106	sphingosine kinase 2	Mus musculus	26-31
25808625-7	2015	Hepatic overexpression of Sphk2 in mice fed a high-fat diet (HFD) led to elevated S1P and reduced ceramide, sphingomyelin, and glucosylceramide in plasma and liver.	Sphingomyelins	108-121	sphingosine kinase 2	Mus musculus	26-31
25808625-7	2015	Hepatic overexpression of Sphk2 in mice fed a high-fat diet (HFD) led to elevated S1P and reduced ceramide, sphingomyelin, and glucosylceramide in plasma and liver.	Glucosylceramides	127-143	sphingosine kinase 2	Mus musculus	26-31
25808625-8	2015	Hepatic accumulation of lipid droplets by HFD feeding was reduced by Sphk2-mediated up-regulation of fatty acid (FA) oxidizing genes and increased FA oxidation in liver.	Fatty Acids	101-111	sphingosine kinase 2	Mus musculus	69-74
25808625-9	2015	In addition, glucose intolerance and insulin resistance were ameliorated by improved hepatic insulin signaling through Sphk2 up-regulation.	Glucose	13-20	sphingosine kinase 2	Mus musculus	119-124
25781541-1	2015	Both of the sphingosine kinase (SK) subtypes SK-1 and SK-2 catalyze the production of the bioactive lipid molecule sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	115-138	sphingosine kinase 2	Mus musculus	54-58
24928515-2	2014	In this study, we used in vitro and in vivo models to explore the role of SPK2-mediated autophagy in isoflurane and hypoxic preconditioning.	Isoflurane	101-111	sphingosine kinase 2	Mus musculus	74-78
25720064-1	2015	FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist.	Fingolimod Hydrochloride	0-6	sphingosine kinase 2	Mus musculus	53-80
25720064-1	2015	FTY720 (fingolimod) is, after its phosphorylation by sphingosine kinase (SPHK) 2, a potent, non-selective sphingosine-1-phosphate (S1P) receptor agonist.	Fingolimod Hydrochloride	8-18	sphingosine kinase 2	Mus musculus	53-80
25637806-0	2015	Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson"s disease and in MPP+ -treated MN9D cells in vitro.	mangion-purified polysaccharide (Candida albicans)	150-154	sphingosine kinase 2	Mus musculus	0-48
25637806-3	2015	Our study indicated a marked down regulation of Sphk2 expression in the substantia nigra region of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model and in the cellular PD model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	103-147	sphingosine kinase 2	Mus musculus	48-53
25637806-3	2015	Our study indicated a marked down regulation of Sphk2 expression in the substantia nigra region of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model and in the cellular PD model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	149-153	sphingosine kinase 2	Mus musculus	48-53
25637806-5	2015	Since mitochondrial dysfunction has been described to be the major pathological event in PD, the present study focused on the role of Sphk2/S1P signaling in promoting mitochondrial functions in the MPTP-induced mouse model of PD and in 1-methyl-4 phenylpyridinium (MPP(+))-treated MN9D cells.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	198-202	sphingosine kinase 2	Mus musculus	134-139
25637806-5	2015	Since mitochondrial dysfunction has been described to be the major pathological event in PD, the present study focused on the role of Sphk2/S1P signaling in promoting mitochondrial functions in the MPTP-induced mouse model of PD and in 1-methyl-4 phenylpyridinium (MPP(+))-treated MN9D cells.	mangion-purified polysaccharide (Candida albicans)	265-268	sphingosine kinase 2	Mus musculus	134-139
25363242-0	2015	Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.	Bile Acids and Salts	11-20	sphingosine kinase 2	Mus musculus	68-88
25363242-4	2015	Here, we report that feeding mice a high-fat diet, infusion of taurocholate into the chronic bile fistula rat, or overexpression of the gene encoding S1PR2 in mouse hepatocytes significantly upregulated hepatic sphingosine kinase 2 (SphK2) but not SphK1.	Taurocholic Acid	63-75	sphingosine kinase 2	Mus musculus	211-231
24928515-9	2014	Beclin 1 knockdown abolished preconditioning-induced autophagy, and SPK2 inhibitors abolished isoflurane-induced disruption of the Beclin 1/Bcl-2 association.	Isoflurane	94-104	sphingosine kinase 2	Mus musculus	68-72
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Sphingosine	0-11	sphingosine kinase 2	Mus musculus	97-117
24859201-4	2014	Sphk2(-/-) mice have lower levels of hippocampal sphingosine-1-phosphate, an endogenous HDAC inhibitor, and reduced histone acetylation, and display deficits in spatial memory and impaired contextual fear extinction.	sphingosine 1-phosphate	49-72	sphingosine kinase 2	Mus musculus	0-5
24659784-5	2014	Investigation of intracellular sites of sphingosine accumulation revealed an elevation of sphingosine in mitochondria due to the activation of neutral ceramidase (NCDase) and the reduced activity of sphingosine kinase 2 (SphK2).	Sphingosine	90-101	sphingosine kinase 2	Mus musculus	199-219
24659784-5	2014	Investigation of intracellular sites of sphingosine accumulation revealed an elevation of sphingosine in mitochondria due to the activation of neutral ceramidase (NCDase) and the reduced activity of sphingosine kinase 2 (SphK2).	Sphingosine	90-101	sphingosine kinase 2	Mus musculus	221-226
24081141-11	2013	Together, these data suggest that attenuation of Sphk activity, particularly Sphk2, leads to increased intracellular sphingolipids and autophagy in macrophages.	Sphingolipids	117-130	sphingosine kinase 2	Mus musculus	77-82
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Sphingosine	0-11	sphingosine kinase 2	Mus musculus	119-124
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Fingolimod Hydrochloride	31-37	sphingosine kinase 2	Mus musculus	97-117
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	Fingolimod Hydrochloride	31-37	sphingosine kinase 2	Mus musculus	119-124
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	FTY 720P	158-166	sphingosine kinase 2	Mus musculus	97-117
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	FTY 720P	158-166	sphingosine kinase 2	Mus musculus	119-124
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	krp203-p	171-179	sphingosine kinase 2	Mus musculus	97-117
23667698-2	2013	Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs.	krp203-p	171-179	sphingosine kinase 2	Mus musculus	119-124
22923732-1	2012	The lipid mediator sphingosine-1-phosphate (S1P) is generated within cells from sphingosine by two sphingosine kinases (SPHK1 and SPHK2).	Sphingosine	19-30	sphingosine kinase 2	Mus musculus	130-135
23359503-1	2013	FcepsilonRI engagement in mast cells (MCs) induces the activation of two distinct sphingosine kinase isoforms (SphK1 and SphK2) to produce sphingosine-1-phosphate, a mediator essential for MC responses.	sphingosine 1-phosphate	139-162	sphingosine kinase 2	Mus musculus	121-126
23359503-4	2013	Using lentiviral-based short hairpin RNA to silence SphK1 or SphK2, we found that SphK2 is required for murine MC degranulation, calcium mobilization, and cytokine and leukotriene production, irrespective of the tissue from which the MC progenitors were derived, the stage of MC granule maturity, or the conditions used for differentiation.	Calcium	129-136	sphingosine kinase 2	Mus musculus	82-87
23359503-4	2013	Using lentiviral-based short hairpin RNA to silence SphK1 or SphK2, we found that SphK2 is required for murine MC degranulation, calcium mobilization, and cytokine and leukotriene production, irrespective of the tissue from which the MC progenitors were derived, the stage of MC granule maturity, or the conditions used for differentiation.	Leukotrienes	168-179	sphingosine kinase 2	Mus musculus	82-87
23043544-3	2012	A genetics-based approach using SphK2- and CCL2-null mice showed both SphK2 and CCL2 to be necessary for the induction of ischemic tolerance following preconditioning with hypoxia, the hypoxia-mimetic cobalt chloride, or the sphingosine-1-phosphate (S1P) agonist FTY720.	cobaltous chloride	201-216	sphingosine kinase 2	Mus musculus	70-75
22393932-6	2012	Ethanol exposure in 7-day-old mice induced sphingosine kinase 2 activation and increased the brain level of S1P transiently 2-4 h after exposure, followed by caspase 3 activation that peaked around 8 h after exposure.	Ethanol	0-7	sphingosine kinase 2	Mus musculus	43-63
22393932-8	2012	These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain.	Ethanol	28-35	sphingosine kinase 2	Mus musculus	46-66
22393932-8	2012	These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain.	Ethanol	158-165	sphingosine kinase 2	Mus musculus	46-66
22322303-5	2012	Histamine activated both SK-1 and SK-2 isoforms; inhibition of SK-1, but not SK-2, attenuated histamine-induced P-selectin up-regulation and neutrophil rolling in vitro.	Histamine	0-9	sphingosine kinase 2	Mus musculus	34-38
22389505-5	2012	The increase in S1P levels by glucose is due to activation of sphingosine kinase 2 (SphK2).	Glucose	30-37	sphingosine kinase 2	Mus musculus	62-82
22389505-5	2012	The increase in S1P levels by glucose is due to activation of sphingosine kinase 2 (SphK2).	Glucose	30-37	sphingosine kinase 2	Mus musculus	84-89
22389505-10	2012	Altogether, our data suggest that glucose activates SphK2 in pancreatic beta cells leading to a rise in S1P levels, which is important for GSIS.	Glucose	34-41	sphingosine kinase 2	Mus musculus	52-57
22322303-7	2012	Finally, the role of both SK-1 and SK-2 in histamine-induced leukocyte rolling in vivo was assessed using pharmacological and genetic methods.	Histamine	43-52	sphingosine kinase 2	Mus musculus	35-39
21756852-3	2012	METHODS: Mice were gavaged with vehicle or ABC294640 (50 mg/kg), a selective inhibitor of SK2, 1 h before surgery and subjected to 1 h-warm ischemia to ~70% of the liver followed by reperfusion.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	43-52	sphingosine kinase 2	Mus musculus	90-93
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane	94-145	sphingosine kinase 2	Mus musculus	30-50
21872577-3	2011	Particularly, SphK2 is necessary for the phosphorylation of the sphingosine analog fingolimod (FTY720), which is protective in rodent stroke models.	Sphingosine	64-75	sphingosine kinase 2	Mus musculus	14-19
21872577-3	2011	Particularly, SphK2 is necessary for the phosphorylation of the sphingosine analog fingolimod (FTY720), which is protective in rodent stroke models.	Fingolimod Hydrochloride	83-93	sphingosine kinase 2	Mus musculus	14-19
21872577-8	2011	Genetic deletion of SphK2 but not SphK1 increased ischemic lesion size and worsened neurological function after tMCAO.	tmcao	112-117	sphingosine kinase 2	Mus musculus	20-25
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	VPC03090-P	147-157	sphingosine kinase 2	Mus musculus	30-50
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	guanosine 5"-o-(3-[(35)s]thio)triphosphate	174-216	sphingosine kinase 2	Mus musculus	30-50
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	Calcium	313-320	sphingosine kinase 2	Mus musculus	30-50
21258214-0	2011	Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	53-62	sphingosine kinase 2	Mus musculus	22-42
21331079-1	2011	We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually signaling proliferation and anti-apoptosis induces neuronal death when generated by sphingosine-kinase2 and when accumulation due to S1P-lyase deficiency occurs.	sphingosine 1-phosphate	51-74	sphingosine kinase 2	Mus musculus	174-193
21391227-6	2011	Several lines of pharmacological and molecular genetic evidence indicate that ROS-PKCdelta-caspase-3 signaling underlies OSU-2S-mediated antitumor effects, and that differences in the antitumor activity between FTY720 and OSU-2S were attributable to SphK2-mediated phosphorylation of FTY720, which represents a metabolic inactivation of its antitumor activity.	Reactive Oxygen Species	78-81	sphingosine kinase 2	Mus musculus	250-255
21391227-6	2011	Several lines of pharmacological and molecular genetic evidence indicate that ROS-PKCdelta-caspase-3 signaling underlies OSU-2S-mediated antitumor effects, and that differences in the antitumor activity between FTY720 and OSU-2S were attributable to SphK2-mediated phosphorylation of FTY720, which represents a metabolic inactivation of its antitumor activity.	OSU-2S	121-127	sphingosine kinase 2	Mus musculus	250-255
21258214-2	2011	Two isozymes, sphingosine kinase 1 and 2 (SK1 and SK2), are responsible for phosphorylation of pro-apoptotic sphingosine to form pro-survival S1P.	Sphingosine	14-25	sphingosine kinase 2	Mus musculus	50-53
19644058-10	2009	CONCLUSIONS: These findings indicate hypoxia-sensitive increases in SphK2 activity may serve as a proximal trigger that ultimately leads to sphingosine-1-phosphate-mediated alterations in gene expression that promote the ischemia-tolerant phenotype.	sphingosine 1-phosphate	140-163	sphingosine kinase 2	Mus musculus	68-73
21258214-3	2011	We have previously reported the antitumor properties of an SK2 selective inhibitor, ABC294640, alone or in combination with the multikinase inhibitor sorafenib in mouse models of kidney carcinoma and pancreatic adenocarcinoma.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	84-93	sphingosine kinase 2	Mus musculus	59-62
20959514-0	2011	Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	36-56
20220090-6	2010	In contrast to wild-type mice, SK2(-/-) mice exhibited attenuated lymphopenia after S1P-lyase inhibition by 4-deoxypyridoxine (DOP).	4-deoxypyridoxine	108-125	sphingosine kinase 2	Mus musculus	31-34
20220090-6	2010	In contrast to wild-type mice, SK2(-/-) mice exhibited attenuated lymphopenia after S1P-lyase inhibition by 4-deoxypyridoxine (DOP).	4-deoxypyridoxine	127-130	sphingosine kinase 2	Mus musculus	31-34
20220090-8	2010	Low S1P concentrations in lymphoid tissues of DOP-treated SK2(-/-) mice were accompanied by higher S1P concentrations in blood, suggesting that SK2(-/-) mice display defective S1P transport from blood into lymphoid tissues.	4-deoxypyridoxine	46-49	sphingosine kinase 2	Mus musculus	58-61
20220090-8	2010	Low S1P concentrations in lymphoid tissues of DOP-treated SK2(-/-) mice were accompanied by higher S1P concentrations in blood, suggesting that SK2(-/-) mice display defective S1P transport from blood into lymphoid tissues.	4-deoxypyridoxine	46-49	sphingosine kinase 2	Mus musculus	144-147
18971925-1	2009	Sphingosine-1-phosphate (S1P), produced by sphingosine kinase 1 (SphK1) or kinase 2 (SphK2), mediates biological effects through intracellular and/or extracellular mechanisms.	sphingosine 1-phosphate	0-23	sphingosine kinase 2	Mus musculus	85-90
16223773-3	2006	Here, we report on the generation of sphingosine kinase 2 (SPHK2) knockout mice and demonstrate that this enzyme is essential for FTY720 phosphate formation in vivo.	Phosphates	137-146	sphingosine kinase 2	Mus musculus	37-57
18783337-4	2008	In contrast, SK-2(-/-) cells were highly resistant to staurosporine-induced apoptosis.	Staurosporine	54-67	sphingosine kinase 2	Mus musculus	13-17
18783337-6	2008	Upon staurosporine treatment, phosphorylation of PKB and Bad decreased in wild-type and SK-1(-/-) cells, but remained high in SK-2(-/-) cells.	Staurosporine	5-18	sphingosine kinase 2	Mus musculus	126-130
16223773-3	2006	Here, we report on the generation of sphingosine kinase 2 (SPHK2) knockout mice and demonstrate that this enzyme is essential for FTY720 phosphate formation in vivo.	Phosphates	137-146	sphingosine kinase 2	Mus musculus	59-64
16223773-5	2006	After direct dosage of FTY720 phosphate, lymphopenia is only transient in this strain, indicating that SPHK2 is constantly required to maintain FTY720 phosphate levels in vivo.	Phosphates	151-160	sphingosine kinase 2	Mus musculus	103-108
16093248-5	2005	Although FTY720 was selectively activated in vivo by SPHK2, other S1P pro-drugs can be phosphorylated to cause lymphopenia through the action of additional sphingosine kinases.	Fingolimod Hydrochloride	9-15	sphingosine kinase 2	Mus musculus	53-58
12874225-5	2003	Analyses of various mutants of each molecule revealed that the region including the proline-rich domain in SPHK2 is probably responsible for the binding to IL-12Rbeta1, while the regions including the carboxyl terminus and Box II in the IL-12Rbeta1 cytoplasmic region appear to be involved in the binding to SPHK2.	Proline	84-91	sphingosine kinase 2	Mus musculus	107-112