PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
24240699-10	2014	Recent work reveals a central role for IRBIT as a third messenger that integrates and synergizes the function of the Ca(2+) and cAMP signaling pathways in activation of epithelial fluid and electrolyte secretion.	Cyclic AMP	128-132	adenosylhomocysteinase like 1	Homo sapiens	39-44
24613710-5	2014	In this review, we discuss crosstalk between the Ca(2+) and cAMP signaling and the function of IRBIT (IP3 receptors binding protein release with IP3) as a third messenger that mediates the synergistic action of the Ca(2+) and cAMP signaling.	Inositol 1,4,5-Trisphosphate	102-105	adenosylhomocysteinase like 1	Homo sapiens	95-100
24613710-5	2014	In this review, we discuss crosstalk between the Ca(2+) and cAMP signaling and the function of IRBIT (IP3 receptors binding protein release with IP3) as a third messenger that mediates the synergistic action of the Ca(2+) and cAMP signaling.	Cyclic AMP	226-230	adenosylhomocysteinase like 1	Homo sapiens	95-100
22929228-5	2012	Proteasome inhibitor MG132, which causes polyQ proteins accumulation and aggregation, enhanced the sequestration of IRBIT.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	21-26	adenosylhomocysteinase like 1	Homo sapiens	116-121
23431199-2	2013	HCO3(-) secretion is highly regulated, with the WNK/SPAK kinase pathway setting the resting state and the IRBIT/PP1 pathway setting the stimulated state.	Bicarbonates	0-4	adenosylhomocysteinase like 1	Homo sapiens	106-111
23431199-6	2013	This module is required for the interaction and activation of NBCe1-B and NBCn1-A by IRBIT and their regulation by phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylinositol 4,5-Diphosphate	115-152	adenosylhomocysteinase like 1	Homo sapiens	85-90
23431199-6	2013	This module is required for the interaction and activation of NBCe1-B and NBCn1-A by IRBIT and their regulation by phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylinositol 4,5-Diphosphate	154-158	adenosylhomocysteinase like 1	Homo sapiens	85-90
22771795-0	2012	IRBIT reduces the apparent affinity for intracellular Mg2+ in inhibition of the electrogenic Na+-HCO3- cotransporter NBCe1-B.	magnesium ion	54-58	adenosylhomocysteinase like 1	Homo sapiens	0-5
22771795-7	2012	Whole-cell patch-clamp experiments showed that coexpression of IRBIT lowered the Mg(2+)(i) sensitivity of bNBCe1-B currents stably expressed in HEK293 cells.	magnesium ion	81-87	adenosylhomocysteinase like 1	Homo sapiens	63-68
22771795-8	2012	Collectively, these results suggest that IRBIT may reduce the apparent affinity for Mg(2+)(i) in inhibition of NBCe1-B activity in mammalian cells.	magnesium ion	84-90	adenosylhomocysteinase like 1	Homo sapiens	41-46
24472682-1	2014	Although AHCYL2 (long-IRBIT) is highly homologous to IRBIT, which regulates ion-transporting proteins including the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B, its functions are poorly understood.	Bicarbonates	135-139	adenosylhomocysteinase like 1	Homo sapiens	22-27
24472682-1	2014	Although AHCYL2 (long-IRBIT) is highly homologous to IRBIT, which regulates ion-transporting proteins including the electrogenic Na(+)-HCO3(-) cotransporter NBCe1-B, its functions are poorly understood.	Bicarbonates	135-139	adenosylhomocysteinase like 1	Homo sapiens	53-58
22826361-4	2012	In addition, bisulfite sequencing to examine methylation patterns in the promoter region of the AHCYL1 gene revealed that 30-38% of the three CpG sites were demethylated in ovarian cancer cells as compared with normal ovarian cells.	hydrogen sulfite	13-22	adenosylhomocysteinase like 1	Homo sapiens	96-102
22929228-6	2012	Furthermore we found that IRBIT sequestration can be prevented by a rho kinase inhibitor, Y-27632.	Y 27632	90-97	adenosylhomocysteinase like 1	Homo sapiens	26-31
21907281-7	2011	Moreover, F508del-CFTR could serve as a scavenger for inositol-1,4,5-trisphosphate [IP3] receptor binding protein released with IP(3) (IRBIT).	f508del	10-17	adenosylhomocysteinase like 1	Homo sapiens	135-140
19224921-0	2009	Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3" processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.	Inositol 1,4,5-Trisphosphate	67-94	adenosylhomocysteinase like 1	Homo sapiens	96-101
20584908-0	2010	Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.	Inositol 1,4,5-Trisphosphate	98-101	adenosylhomocysteinase like 1	Homo sapiens	147-152
20584908-2	2010	We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) plays a critical role in stimulation of NHE3 in response to elevated intracellular Ca(2+) concentration ([Ca(2+)](i)).	Inositol	30-38	adenosylhomocysteinase like 1	Homo sapiens	126-131
20584908-2	2010	We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) plays a critical role in stimulation of NHE3 in response to elevated intracellular Ca(2+) concentration ([Ca(2+)](i)).	Inositol 1,4,5-Trisphosphate	30-57	adenosylhomocysteinase like 1	Homo sapiens	126-131
20584908-11	2010	Several serine residues of IRBIT are thought to be important for IRBIT binding.	Serine	8-14	adenosylhomocysteinase like 1	Homo sapiens	27-32
20584908-11	2010	Several serine residues of IRBIT are thought to be important for IRBIT binding.	Serine	8-14	adenosylhomocysteinase like 1	Homo sapiens	65-70
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	13-16	adenosylhomocysteinase like 1	Homo sapiens	43-48
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	13-16	adenosylhomocysteinase like 1	Homo sapiens	70-75
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	21-24	adenosylhomocysteinase like 1	Homo sapiens	43-48
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	21-24	adenosylhomocysteinase like 1	Homo sapiens	70-75
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	21-24	adenosylhomocysteinase like 1	Homo sapiens	43-48
20584908-12	2010	Mutations of Ser-68, Ser-71, and Ser-74 of IRBIT decreased binding of IRBIT to NHE3 and its effect on NHE3 activity.	Serine	21-24	adenosylhomocysteinase like 1	Homo sapiens	70-75
19224921-5	2009	Furthermore, tert-butylhydroquinone (tBHQ), an agent that induces oxidative stress, increased the phosphorylation level of IRBIT in vivo and in parallel enhanced the interaction between IRBIT and CPSF and promoted the cytoplasmic distribution of endogenous Fip1.	2-tert-butylhydroquinone	13-35	adenosylhomocysteinase like 1	Homo sapiens	123-128
19224921-5	2009	Furthermore, tert-butylhydroquinone (tBHQ), an agent that induces oxidative stress, increased the phosphorylation level of IRBIT in vivo and in parallel enhanced the interaction between IRBIT and CPSF and promoted the cytoplasmic distribution of endogenous Fip1.	2-tert-butylhydroquinone	13-35	adenosylhomocysteinase like 1	Homo sapiens	186-191
19224921-5	2009	Furthermore, tert-butylhydroquinone (tBHQ), an agent that induces oxidative stress, increased the phosphorylation level of IRBIT in vivo and in parallel enhanced the interaction between IRBIT and CPSF and promoted the cytoplasmic distribution of endogenous Fip1.	2-tert-butylhydroquinone	37-41	adenosylhomocysteinase like 1	Homo sapiens	123-128
19224921-5	2009	Furthermore, tert-butylhydroquinone (tBHQ), an agent that induces oxidative stress, increased the phosphorylation level of IRBIT in vivo and in parallel enhanced the interaction between IRBIT and CPSF and promoted the cytoplasmic distribution of endogenous Fip1.	2-tert-butylhydroquinone	37-41	adenosylhomocysteinase like 1	Homo sapiens	186-191
19224921-4	2009	The main target for IRBIT in CPSF was Fip1 subunit, and the phosphorylation of the serine-rich region of IRBIT was required both for direct association with Fip1 in vitro and for redistribution of Fip1 into the cytoplasm of intact cells.	Serine	83-89	adenosylhomocysteinase like 1	Homo sapiens	20-25
19224921-4	2009	The main target for IRBIT in CPSF was Fip1 subunit, and the phosphorylation of the serine-rich region of IRBIT was required both for direct association with Fip1 in vitro and for redistribution of Fip1 into the cytoplasm of intact cells.	Serine	83-89	adenosylhomocysteinase like 1	Homo sapiens	105-110
18829453-0	2008	IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.	Inositol 1,4,5-Trisphosphate	36-39	adenosylhomocysteinase like 1	Homo sapiens	0-5
18829453-0	2008	IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.	Calcium	156-163	adenosylhomocysteinase like 1	Homo sapiens	0-5
16793548-0	2006	IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.	Inositol 1,4,5-Trisphosphate	17-20	adenosylhomocysteinase like 1	Homo sapiens	0-5
17233576-11	2007	We have also found the role of IP3 is not only to release Ca2+ but also to release IRBIT which binds to the IP3 binding core of IP3R.	Inositol 1,4,5-Trisphosphate	31-34	adenosylhomocysteinase like 1	Homo sapiens	83-88
17233576-11	2007	We have also found the role of IP3 is not only to release Ca2+ but also to release IRBIT which binds to the IP3 binding core of IP3R.	Inositol 1,4,5-Trisphosphate	108-111	adenosylhomocysteinase like 1	Homo sapiens	83-88
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	28-31	adenosylhomocysteinase like 1	Homo sapiens	50-55
16793548-2	2006	We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3.	Inositol 1,4,5-Trisphosphate	76-79	adenosylhomocysteinase like 1	Homo sapiens	50-55
16793548-3	2006	In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3 by [3H]IP3 binding assays, in vitro Ca2+ release assays, and Ca2+ imaging of intact cells.	Inositol 1,4,5-Trisphosphate	72-75	adenosylhomocysteinase like 1	Homo sapiens	37-42
16793548-3	2006	In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3 by [3H]IP3 binding assays, in vitro Ca2+ release assays, and Ca2+ imaging of intact cells.	Tritium	103-105	adenosylhomocysteinase like 1	Homo sapiens	37-42
16793548-3	2006	In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3 by [3H]IP3 binding assays, in vitro Ca2+ release assays, and Ca2+ imaging of intact cells.	Inositol 1,4,5-Trisphosphate	95-98	adenosylhomocysteinase like 1	Homo sapiens	37-42
16793548-4	2006	Multiserine phosphorylation of IRBIT was essential for the binding, and 10 of the 12 key amino acids in IP3R for IP3 recognition participated in binding to IRBIT.	multiserine	0-11	adenosylhomocysteinase like 1	Homo sapiens	31-36
16793548-4	2006	Multiserine phosphorylation of IRBIT was essential for the binding, and 10 of the 12 key amino acids in IP3R for IP3 recognition participated in binding to IRBIT.	multiserine	0-11	adenosylhomocysteinase like 1	Homo sapiens	156-161
16793548-4	2006	Multiserine phosphorylation of IRBIT was essential for the binding, and 10 of the 12 key amino acids in IP3R for IP3 recognition participated in binding to IRBIT.	Inositol 1,4,5-Trisphosphate	104-107	adenosylhomocysteinase like 1	Homo sapiens	31-36
16793548-4	2006	Multiserine phosphorylation of IRBIT was essential for the binding, and 10 of the 12 key amino acids in IP3R for IP3 recognition participated in binding to IRBIT.	Inositol 1,4,5-Trisphosphate	104-107	adenosylhomocysteinase like 1	Homo sapiens	156-161
16793548-5	2006	We propose a unique mode of IP3R regulation in which IP3 sensitivity is regulated by IRBIT acting as an endogenous "pseudoligand" whose inhibitory activity can be modulated by its phosphorylation status.	Inositol 1,4,5-Trisphosphate	28-31	adenosylhomocysteinase like 1	Homo sapiens	85-90
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	phosphatidylinositol 3-phosphate	355-387	adenosylhomocysteinase like 1	Homo sapiens	37-43
16527252-1	2006	IRBIT has previously been shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) in an IP3-sensitive way.	Inositol 1,4,5-Trisphosphate	83-86	adenosylhomocysteinase like 1	Homo sapiens	0-5
16527252-3	2006	We now show that IRBIT can directly interact with the IP3R, and that both the suppressor domain and the IP3-binding core of the IP3R are essential for a strong interaction.	Inositol 1,4,5-Trisphosphate	54-57	adenosylhomocysteinase like 1	Homo sapiens	17-22
16527252-6	2006	Finally, we demonstrated that this interaction functionally affects the IP3R: IRBIT inhibits both IP3 binding and IP3-induced Ca2+ release.	Inositol 1,4,5-Trisphosphate	72-75	adenosylhomocysteinase like 1	Homo sapiens	78-83
16527252-6	2006	Finally, we demonstrated that this interaction functionally affects the IP3R: IRBIT inhibits both IP3 binding and IP3-induced Ca2+ release.	Inositol 1,4,5-Trisphosphate	98-101	adenosylhomocysteinase like 1	Homo sapiens	78-83
33237573-8	2021	However, NBCe1-B can be activated by interaction with the IP3R-binding protein released with inositol 1,4,5-trisphosphate (IRBIT).	Inositol 1,4,5-Trisphosphate	93-121	adenosylhomocysteinase like 1	Homo sapiens	123-128
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Aspartic Acid	95-98	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Glutamic Acid	99-102	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Asparagine	116-119	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Glutamine	120-123	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Serine	139-142	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Threonine	143-146	adenosylhomocysteinase like 1	Homo sapiens	24-29
33237573-13	2021	The interaction between IRBIT and NBCe1-B is abolished by mutating a set of negatively-charged Asp/Glu residues (to Asn/Gln) plus a set of Ser/Thr residues (to Ala) in the PEST domain of IRBIT.	Alanine	160-163	adenosylhomocysteinase like 1	Homo sapiens	24-29
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	Adenosine	170-179	adenosylhomocysteinase like 1	Homo sapiens	37-43
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	Adenosine	170-179	adenosylhomocysteinase like 1	Homo sapiens	222-228
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	Adenosine	170-179	adenosylhomocysteinase like 1	Homo sapiens	230-259
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	phosphatidylinositol 3-phosphate	345-353	adenosylhomocysteinase like 1	Homo sapiens	37-43
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	S-Adenosylhomocysteine	394-419	adenosylhomocysteinase like 1	Homo sapiens	37-43
33993848-7	2022	Our study uncovers a new axis of SAH-AHCYL1-PIK3C3, which senses the intracellular level of SAH to inhibit autophagy in an MTORC1-independent manner.Abbreviations: ADOX: adenosine dialdehyde; AHCY: adenosylhomocysteinase; AHCYL1: adenosylhomocysteinase like 1; cLEU: cycloleucine; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PtdIns3P: phosphatidylinositol-3-phosphate; SAH: S-adenosyl-l-homocysteine; SAM: S-adenosyl-l-methionine.	S-Adenosylmethionine	426-449	adenosylhomocysteinase like 1	Homo sapiens	37-43
32119862-10	2020	Finally, Ala-substitution of Ser68, a key phosphorylation site in the PEST domain of IRBIT, causes distinct functional consequences depending on the structural context of the Nt appendage in different IRBIT isoforms.	Alanine	9-12	adenosylhomocysteinase like 1	Homo sapiens	85-90
33727633-0	2021	Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2.	Bicarbonates	64-68	adenosylhomocysteinase like 1	Homo sapiens	5-10
33727633-0	2021	Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2.	Bicarbonates	64-68	adenosylhomocysteinase like 1	Homo sapiens	20-25
33727633-8	2021	The mRNA levels of AE2 in each KO cell did not change, and the downregulation of AE2 in L-IRBIT KO cells was inhibited by bafilomycin A1.	bafilomycin A1	122-136	adenosylhomocysteinase like 1	Homo sapiens	90-95
32867284-0	2020	Protective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells.	Sodium Bicarbonate	28-46	adenosylhomocysteinase like 1	Homo sapiens	19-24
32119862-10	2020	Finally, Ala-substitution of Ser68, a key phosphorylation site in the PEST domain of IRBIT, causes distinct functional consequences depending on the structural context of the Nt appendage in different IRBIT isoforms.	Alanine	9-12	adenosylhomocysteinase like 1	Homo sapiens	201-206
29808931-5	2018	These regions also include binding determinants for IRBIT (inositol trisphosphate (IP3 )-receptor binding protein released with IP3 ), which relieves autoinhibition.	inositol 1,2,3-trisphosphate	59-81	adenosylhomocysteinase like 1	Homo sapiens	52-57
31366495-1	2019	BACKGROUND/AIM: We investigated whether the expression of inositol 1, 4, 5-trisphosphate receptor-binding protein released with inositol 1, 4, 5-trisphosphate (IRBIT) in clinical gastric cancer (GC) patients could predict the therapeutic response to postoperative adjuvant chemotherapy.	Inositol 1,4,5-Trisphosphate	58-88	adenosylhomocysteinase like 1	Homo sapiens	160-165
29808931-5	2018	These regions also include binding determinants for IRBIT (inositol trisphosphate (IP3 )-receptor binding protein released with IP3 ), which relieves autoinhibition.	Inositol 1,4,5-Trisphosphate	83-86	adenosylhomocysteinase like 1	Homo sapiens	52-57
29808931-5	2018	These regions also include binding determinants for IRBIT (inositol trisphosphate (IP3 )-receptor binding protein released with IP3 ), which relieves autoinhibition.	Inositol 1,4,5-Trisphosphate	128-131	adenosylhomocysteinase like 1	Homo sapiens	52-57
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	44-72	adenosylhomocysteinase like 1	Homo sapiens	0-5
29287955-7	2018	Another regulatory protein of IP3R, IP3R-binding protein released with IP3 (IRBIT), cooperates with or counteracts the Bcl-2 family member depending on cellular states.	Inositol 1,4,5-Trisphosphate	30-33	adenosylhomocysteinase like 1	Homo sapiens	76-81
29302216-7	2018	These results suggested that like IRBIT, PP1 was another novel regulator of HCO3- secretion in several types of epithelia.	Bicarbonates	76-80	adenosylhomocysteinase like 1	Homo sapiens	34-39
28348216-1	2017	IRBIT [inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with inositol 1,4,5-trisphosphate (IP3)] is a multifunctional protein that regulates several target molecules such as ion channels, transporters, polyadenylation complex, and kinases.	Inositol 1,4,5-Trisphosphate	7-35	adenosylhomocysteinase like 1	Homo sapiens	0-5
28348216-1	2017	IRBIT [inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with inositol 1,4,5-trisphosphate (IP3)] is a multifunctional protein that regulates several target molecules such as ion channels, transporters, polyadenylation complex, and kinases.	Inositol 1,4,5-Trisphosphate	46-49	adenosylhomocysteinase like 1	Homo sapiens	0-5
28348216-2	2017	Through its interaction with multiple targets, IRBIT contributes to calcium signaling, electrolyte transport, mRNA processing, cell cycle, and neuronal function.	Calcium	68-75	adenosylhomocysteinase like 1	Homo sapiens	47-52
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	74-77	adenosylhomocysteinase like 1	Homo sapiens	0-5
27995898-1	2016	IRBIT is a molecule that interacts with the inositol 1,4,5-trisphosphate (IP3)-binding pocket of the IP3 receptor (IP3R), whereas the antiapoptotic protein, Bcl2l10, binds to another part of the IP3-binding domain.	Inositol 1,4,5-Trisphosphate	101-104	adenosylhomocysteinase like 1	Homo sapiens	0-5
27279487-2	2016	We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells.	Inositol	30-38	adenosylhomocysteinase like 1	Homo sapiens	128-133
27279487-2	2016	We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells.	Inositol 1,4,5-Trisphosphate	30-58	adenosylhomocysteinase like 1	Homo sapiens	128-133
27279487-8	2016	We further demonstrated that IRBIT was indispensable for the ANG II-provoked increase in NHERF1-NHE3 interactions and that phosphorylation of IRBIT at Ser(68) was necessary for the assembly of the NHEF1-IRBIT-NHE3 complex.	Serine	151-154	adenosylhomocysteinase like 1	Homo sapiens	142-147
27279487-8	2016	We further demonstrated that IRBIT was indispensable for the ANG II-provoked increase in NHERF1-NHE3 interactions and that phosphorylation of IRBIT at Ser(68) was necessary for the assembly of the NHEF1-IRBIT-NHE3 complex.	Serine	151-154	adenosylhomocysteinase like 1	Homo sapiens	142-147
25497594-8	2015	Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.	Inositol 1,4,5-Trisphosphate	10-13	adenosylhomocysteinase like 1	Homo sapiens	72-77
26716707-3	2016	The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/SPS1-related proline/alanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).	Inositol 1,4,5-Trisphosphate	133-136	adenosylhomocysteinase like 1	Homo sapiens	183-188
25502317-5	2015	We obtained the age-specific organ burdens after the inhalation of those radionuclides from the Dose and Risk Calculation Software (DCAL) program.	Radioisotopes	73-86	adenosylhomocysteinase like 1	Homo sapiens	132-136
25497594-8	2015	Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.	inositol 1,2,3-trisphosphate	121-143	adenosylhomocysteinase like 1	Homo sapiens	72-77
25561556-7	2015	IP3 receptor binding protein released with IP3 (IRBIT) activation of NBCe1-B unmasks a second high affinity Cl(-) in interacting GXXXP-dependent site.	gxxxp	129-134	adenosylhomocysteinase like 1	Homo sapiens	0-46
25561556-7	2015	IP3 receptor binding protein released with IP3 (IRBIT) activation of NBCe1-B unmasks a second high affinity Cl(-) in interacting GXXXP-dependent site.	gxxxp	129-134	adenosylhomocysteinase like 1	Homo sapiens	48-53
24518248-2	2014	Unexpectedly, many functions have subsequently been identified for IRBIT including the activation of multiple ion channels and ion transporters, such as the Na(+)/HCO3(-) co-transporter NBCe1-B, the Na(+)/H(+) exchanger NHE3, the Cl(-) channel cystic fibrosis transmembrane conductance regulator (CFTR), and the Cl(-)/HCO3(-) exchanger Slc26a6.	Bicarbonates	163-167	adenosylhomocysteinase like 1	Homo sapiens	67-72
24518248-3	2014	The characteristic serine-rich region in IRBIT plays a critical role in the functions of this protein.	Serine	19-25	adenosylhomocysteinase like 1	Homo sapiens	41-46
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	54-81	adenosylhomocysteinase like 1	Homo sapiens	40-45
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	83-87	adenosylhomocysteinase like 1	Homo sapiens	40-45
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	134-138	adenosylhomocysteinase like 1	Homo sapiens	40-45
25237103-5	2014	Formation of the RNR-IRBIT complex is regulated through phosphorylation of IRBIT, and ablation of IRBIT expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.	Parathion	147-151	adenosylhomocysteinase like 1	Homo sapiens	21-26
25367944-1	2014	IRBIT inhibits ribonucleotide reductase (RNR) by stabilizing dATP binding to the RNR activity site.	2'-deoxyadenosine triphosphate	61-65	adenosylhomocysteinase like 1	Homo sapiens	0-5