PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12754374-7	2003	Daily injection of adrenaline, administered at a fixed time for 6 days, recovered oscillations of mPer2 and mBmal1 gene expression in the liver of mice with SCN lesion on day 7.	Epinephrine	19-29	basic helix-loop-helix ARNT like 1	Mus musculus	108-114
10403839-4	1999	Of the three splice variants, mBMAL1b extends for 1878 bp in the coding sequence, which is 91% identical to that of hBMAL1b; its deduced amino acid sequence is 626 residues long and is 98% identical to that of hBMAL1b, and sequence identities in the bHLH, PAS-A, and PAS-B regions are 98, 100, and 100%, respectively.	Protactinium	256-259	basic helix-loop-helix ARNT like 1	Mus musculus	30-37
10403839-4	1999	Of the three splice variants, mBMAL1b extends for 1878 bp in the coding sequence, which is 91% identical to that of hBMAL1b; its deduced amino acid sequence is 626 residues long and is 98% identical to that of hBMAL1b, and sequence identities in the bHLH, PAS-A, and PAS-B regions are 98, 100, and 100%, respectively.	Protactinium	267-270	basic helix-loop-helix ARNT like 1	Mus musculus	30-37
10403839-5	1999	mBMAL1b" arises from alternative usage of exon 2, which results in a 7-amino-acid insertion and alternative splice acceptor usage at the intron 9/exon 10 splice junction, which causes an alanine residue deletion.	Alanine	187-194	basic helix-loop-helix ARNT like 1	Mus musculus	0-7
10403839-6	1999	mBMAL1b" encodes 632 amino acids and contains the bHLH/PAS domains.	Protactinium	55-58	basic helix-loop-helix ARNT like 1	Mus musculus	0-7
33793874-8	2021	Bmal1 ablation sensitized mice to Semen Strychni-induced toxicity (with increased levels of plasma creatinine and CK-BB) and abolished the time dependency of toxicity.	Creatinine	99-109	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
34936504-6	2022	Treatment with SR9009, an agonist of NR1D1, significantly reduced the expression of Bmal1, Per2, and Dbp in mouse GCs.	SR9009	15-21	basic helix-loop-helix ARNT like 1	Mus musculus	84-89
34563619-6	2022	Furthermore, paclitaxel disrupted circulating corticosterone rhythms in DD by elevating its levels across a 24-hour cycle, which correlated with blunted amplitudes of Arntl, Nr1d1, Per1, and Star rhythms in the adrenal glands.	Paclitaxel	13-23	basic helix-loop-helix ARNT like 1	Mus musculus	167-172
34525889-3	2022	Cyclic stimulation with dexamethasone at different time intervals (18-28 h, 3 times regularly) revealed that Bmal1-Luc bioluminescence rhythms can be entrained to 22 and 24 h cycles during the stimulation period, but not to other cycles.	Dexamethasone	24-37	basic helix-loop-helix ARNT like 1	Mus musculus	109-114
34879384-0	2021	Role of Different Doses of Ketamine in Postoperative Neurocognitive Function in Aged Mice Undergoing Partial Hepatectomy by Regulating the Bmal1/NMDA/NF-Kappab Axis.	Ketamine	27-35	basic helix-loop-helix ARNT like 1	Mus musculus	139-144
34879384-1	2021	BACKGROUND: The current study set out to probe the function of different doses of ketamine in postoperative neurocognitive disorder (PND) in aged mice undergoing partial hepatectomy (PH) with the involvement of the brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1)/n-methyl-D-aspartate (NMDA)/nuclear factor-kappa B (NF-kappaB) axis.	Ketamine	82-90	basic helix-loop-helix ARNT like 1	Mus musculus	295-300
34879384-8	2021	In Bmal1-KO mice, the NMDA/NF-kappaB axis was activated, the release of inflammatory cytokines was promoted, and hippocampus-dependent memory was impaired, which were reversed by a subanesthetic dose of ketamine.	Ketamine	203-211	basic helix-loop-helix ARNT like 1	Mus musculus	3-8
34879384-9	2021	CONCLUSION: Altogether, findings obtained in our study indicated that a subanesthetic dose of ketamine activated Bmal1, downregulated the NMDA/NF-kappaB axis, and reduced inflammation and microglia activation to alleviate PND in aged mice undergoing PH.	Ketamine	94-102	basic helix-loop-helix ARNT like 1	Mus musculus	113-118
34800293-0	2021	Melatonin ameliorates cerebral ischemia-reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1-BMAL1 pathway.	Melatonin	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	113-118
34800293-8	2021	Additionally, our cellular experiments demonstrated that melatonin increased the SIRT1-BMAL1 pathway-related proteins" expression in a dose-dependent manner.	Melatonin	57-66	basic helix-loop-helix ARNT like 1	Mus musculus	87-92
34800293-9	2021	In conclusion, these results indicate that melatonin treatment can protect against CIR-induced brain damage in diabetic mice, which may be achieved by the autophagy enhancement mediated by the SIRT1-BMAL1 pathway.	Melatonin	43-52	basic helix-loop-helix ARNT like 1	Mus musculus	199-204
34541876-6	2021	Alcohol significantly disrupted mRNA expression of Bmal1, Per1/2, and Cry1/2 in addition to perturbing the circadian pattern of clock-controlled genes, Myod1, Dbp, Tef, and Bhlhe40 (p<0.05) in muscle.	Alcohols	0-7	basic helix-loop-helix ARNT like 1	Mus musculus	51-56
34702951-0	2021	Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner.	Alcohols	33-40	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
34702951-2	2021	Analysis of clock genes revealed a potential role of Bmal1 in the control of alcohol drinking behavior.	Alcohols	77-84	basic helix-loop-helix ARNT like 1	Mus musculus	53-58
34702951-3	2021	However, a causal role of Bmal1 and neural pathways through which it may influence alcohol intake have not yet been established.	Alcohols	83-90	basic helix-loop-helix ARNT like 1	Mus musculus	26-31
34702951-4	2021	Here we show that selective ablation of Bmal1 (Cre/loxP system) from medium spiny neurons of the striatum induces sexual dimorphic alterations in alcohol consumption in mice, resulting in augmentation of voluntary alcohol intake in males and repression of intake in females.	Alcohols	146-153	basic helix-loop-helix ARNT like 1	Mus musculus	40-45
34702951-4	2021	Here we show that selective ablation of Bmal1 (Cre/loxP system) from medium spiny neurons of the striatum induces sexual dimorphic alterations in alcohol consumption in mice, resulting in augmentation of voluntary alcohol intake in males and repression of intake in females.	Alcohols	214-221	basic helix-loop-helix ARNT like 1	Mus musculus	40-45
34702951-8	2021	Striatal Bmal1 and Per2 expression thus may contribute to the propensity to consume alcohol in a sex -specific manner in mice.	Alcohols	84-91	basic helix-loop-helix ARNT like 1	Mus musculus	9-14
34416563-2	2021	Male Bmal1-/- mice are infertile with low serum testosterone levels and decreased expression of testicular steroidogenic genes, suggesting that circadian clock genes regulate testosterone biosynthesis by activating steroidogenic gene transcription.	Testosterone	48-60	basic helix-loop-helix ARNT like 1	Mus musculus	5-10
34416563-2	2021	Male Bmal1-/- mice are infertile with low serum testosterone levels and decreased expression of testicular steroidogenic genes, suggesting that circadian clock genes regulate testosterone biosynthesis by activating steroidogenic gene transcription.	Testosterone	175-187	basic helix-loop-helix ARNT like 1	Mus musculus	5-10
34416563-4	2021	Using Bmal1-/- mice and their wild-type (WT) siblings, we aimed to identify additional genes by which the circadian clock regulates testosterone synthesis.	Testosterone	132-144	basic helix-loop-helix ARNT like 1	Mus musculus	6-11
34416563-6	2021	Low serum testosterone levels were detected in the Bmal1-/- mice.	Testosterone	10-22	basic helix-loop-helix ARNT like 1	Mus musculus	51-56
34416563-8	2021	The cholesterol metabolism pathway was significantly enriched in the KEGG pathway analysis, and there was lower expression of three apolipoprotein genes (Apoa1, Apoa2, and Apoc3) at CT2 in the testes of Bmal1-/- mice than in those of WT mice.	Cholesterol	4-15	basic helix-loop-helix ARNT like 1	Mus musculus	203-208
34416563-12	2021	Oil Red O staining showed decreased lipid aggregation in the Leydig cells of Bmal1-/- mouse testes.	oil red O	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	77-82
34626126-0	2021	Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.	Cyclic AMP	64-68	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
34626126-3	2021	Here, we show that global and liver-specific Bmal1-deficient mice maintained on a chow or a Western diet developed hyperlipidemia, denoted by the presence of higher amounts of triglyceride- and ApoAIV-rich larger chylomicron and very-low-density lipoprotein, due to overproduction.	Triglycerides	176-188	basic helix-loop-helix ARNT like 1	Mus musculus	45-50
34324866-0	2021	REV-ERBalpha agonist SR9009 suppresses IL-1beta production in macrophages through BMAL1-dependent inhibition of inflammasome.	SR9009	21-27	basic helix-loop-helix ARNT like 1	Mus musculus	82-87
34324866-7	2021	Particularly, the effect of SR9009 on inhibiting NLRP3-mediated IL-1beta and IL-18 production in macrophages was dependent on BMAL1 expression.	SR9009	28-34	basic helix-loop-helix ARNT like 1	Mus musculus	126-131
34542664-0	2022	L-Theanine inhibits melanoma cell growth and migration via regulating expression of the clock gene BMAL1.	theanine	0-10	basic helix-loop-helix ARNT like 1	Mus musculus	99-104
34542664-10	2022	L-Theanine significantly enhanced the expression of BMAL1, a clock gene in melanoma cells.	theanine	0-10	basic helix-loop-helix ARNT like 1	Mus musculus	52-57
34542664-11	2022	Down-regulation of BMAL1 suppressed the anti-cancer effects of L-theanine on melanoma cells.	theanine	63-73	basic helix-loop-helix ARNT like 1	Mus musculus	19-24
34542664-12	2022	Further experiments indicated that the p53 transcriptional activity raised by L-theanine was dependent on BMAL1 expression in melanoma cells.	theanine	78-88	basic helix-loop-helix ARNT like 1	Mus musculus	106-111
34542664-13	2022	CONCLUSION: L-Theanine exerts the anti-cancer effect on melanoma cells through attenuating the proliferation and migration, and promoting apoptosis of them, which is dependent on the regulation of the clock gene Bmal1 in melanoma cells.	theanine	12-22	basic helix-loop-helix ARNT like 1	Mus musculus	212-217
34493722-6	2021	Mechanistic studies uncover that BMAL1 transactivates the Dgat2 gene (encoding the triacylglycerol synthesis enzyme DGAT2) via direct binding to an E-box in the promoter, thereby promoting dietary fat absorption.	Triglycerides	83-98	basic helix-loop-helix ARNT like 1	Mus musculus	33-38
34493722-8	2021	Moreover, small-molecule targeting of REV-ERBalpha/BMAL1 by SR9009 ameliorates HFD-induced obesity in mice.	SR9009	60-66	basic helix-loop-helix ARNT like 1	Mus musculus	51-56
34152143-4	2021	Furthermore, 3betamWi-A dose-dependently upregulated the mRNA expression and promoter activities of Bmal1 after dexamethasone stimulation and of the nuclear orphan receptors, Rora and Nr1d1, that comprise the stabilization loop for Bmal1 oscillatory expression.	2,3-dihydro-3beta-methoxy withaferin-A	13-23	basic helix-loop-helix ARNT like 1	Mus musculus	100-105
34152143-4	2021	Furthermore, 3betamWi-A dose-dependently upregulated the mRNA expression and promoter activities of Bmal1 after dexamethasone stimulation and of the nuclear orphan receptors, Rora and Nr1d1, that comprise the stabilization loop for Bmal1 oscillatory expression.	2,3-dihydro-3beta-methoxy withaferin-A	13-23	basic helix-loop-helix ARNT like 1	Mus musculus	232-237
34152143-4	2021	Furthermore, 3betamWi-A dose-dependently upregulated the mRNA expression and promoter activities of Bmal1 after dexamethasone stimulation and of the nuclear orphan receptors, Rora and Nr1d1, that comprise the stabilization loop for Bmal1 oscillatory expression.	Dexamethasone	112-125	basic helix-loop-helix ARNT like 1	Mus musculus	100-105
34261484-6	2021	Knockout of Bmal1 in hippocampal dentate gyrus (DG) neurons of Bmal1flox/flox mice by Synapsin 1 (Syn1) promoter AAV (adeno-associated virus) lowered the threshold of seizures induced by pilocarpine administration.	Pilocarpine	187-198	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
35236106-12	2022	Further study demonstrated that Bmal1 downregulation in VSMCs increased VSMC migration, monocyte transmigration, reactive oxygen species levels, and VSMCs apoptosis.	Reactive Oxygen Species	113-136	basic helix-loop-helix ARNT like 1	Mus musculus	32-37
35301425-7	2022	Interestingly, the antidiabetic drug metformin reversed mTORC1 hyperactivation and alleviated major behavioral and PC deficits in Bmal1 KO mice.	Metformin	37-46	basic helix-loop-helix ARNT like 1	Mus musculus	130-135
35279674-8	2022	miR-142-3p was elevated with aging, which downregulated Bmal1 and diminished the osteogenic potential of BMSCs.	mir-142-3p	0-10	basic helix-loop-helix ARNT like 1	Mus musculus	56-61
35149852-5	2022	We demonstrated that hepatocyte-specific loss of NCoR1 attenuated liver steatosis by promoting fatty acid oxidation by upregulating BMAL1 (a circadian clock component that has been reported to promote peroxisome proliferator activated receptor alpha (PPARalpha)-mediated fatty beta-oxidation by upregulating de novo lipid synthesis).	Fatty Acids	95-105	basic helix-loop-helix ARNT like 1	Mus musculus	132-137
35204763-6	2022	The iMS-BMAL1 KO mice excreted less potassium during the rest phase during the normal diet but there was no genotype difference during the active phase.	Potassium	36-45	basic helix-loop-helix ARNT like 1	Mus musculus	8-13
35115380-0	2022	BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells.	NAD	54-58	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
35115380-7	2022	Finally, hypoxic cell proliferation and myofiber formation in Bmal1-deficient myoblasts are restored by increasing cytosolic NAD+ Together, we identify the MuSC clock as a pivotal regulator of oxygen-dependent myoblast cell fate and muscle repair through the control of the NAD+-driven response to injury.	NAD	125-129	basic helix-loop-helix ARNT like 1	Mus musculus	62-67
35115380-7	2022	Finally, hypoxic cell proliferation and myofiber formation in Bmal1-deficient myoblasts are restored by increasing cytosolic NAD+ Together, we identify the MuSC clock as a pivotal regulator of oxygen-dependent myoblast cell fate and muscle repair through the control of the NAD+-driven response to injury.	Oxygen	193-199	basic helix-loop-helix ARNT like 1	Mus musculus	62-67
35115380-7	2022	Finally, hypoxic cell proliferation and myofiber formation in Bmal1-deficient myoblasts are restored by increasing cytosolic NAD+ Together, we identify the MuSC clock as a pivotal regulator of oxygen-dependent myoblast cell fate and muscle repair through the control of the NAD+-driven response to injury.	NAD	274-278	basic helix-loop-helix ARNT like 1	Mus musculus	62-67
33982090-0	2021	Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice.	Biotin	55-61	basic helix-loop-helix ARNT like 1	Mus musculus	73-78
33982090-7	2021	A biotin labeling assay in mouse embryonic fibroblasts revealed the protein biotinylation activity of BMAL1-BirA* expressed in knock-in mouse cells depending on biotin supplementation.	Biotin	2-8	basic helix-loop-helix ARNT like 1	Mus musculus	102-107
33982090-7	2021	A biotin labeling assay in mouse embryonic fibroblasts revealed the protein biotinylation activity of BMAL1-BirA* expressed in knock-in mouse cells depending on biotin supplementation.	Biotin	76-82	basic helix-loop-helix ARNT like 1	Mus musculus	102-107
33982090-8	2021	Lastly, feeding a 0.5% biotin diet for 7 days induced protein biotinylation in the brain, heart, testis, and liver of BMAL1-BioID mice without adverse effects on spermatogenesis.	Biotin	23-29	basic helix-loop-helix ARNT like 1	Mus musculus	118-123
33982090-9	2021	In the kidney, the biotin diet increased biotinylated protein levels in BMAL1-BioID and control mice, suggesting the existence of endogenous biotinylation activity.	Biotin	19-25	basic helix-loop-helix ARNT like 1	Mus musculus	72-77
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	basic helix-loop-helix ARNT like 1	Mus musculus	90-95
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	basic helix-loop-helix ARNT like 1	Mus musculus	127-132
33554778-0	2021	Bmal1 promotes prostaglandin E2 synthesis by up-regulating Ptgs2 transcription in response to increasing estradiol levels in day 4 pregnant mice.	Dinoprostone	15-31	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
33554778-0	2021	Bmal1 promotes prostaglandin E2 synthesis by up-regulating Ptgs2 transcription in response to increasing estradiol levels in day 4 pregnant mice.	Estradiol	105-114	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
33554778-7	2021	Consistently, the mRNA levels of clock genes (Bmal1 and Per2), Vegf, and Ptgs2 were markedly increased by E2 treatment of UESCs in the presence of P4.	Estradiol	106-108	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
33554778-10	2021	Bmal1 knockdown also inhibited PGE2 synthesis.	Dinoprostone	31-35	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
33554778-12	2021	Thus, these data suggest that Bmal1 in mice promotes PGE2 synthesis by up-regulating Ptgs2 in response to increases in E2 on D4 of pregnancy.	Dinoprostone	53-57	basic helix-loop-helix ARNT like 1	Mus musculus	30-35
33554778-12	2021	Thus, these data suggest that Bmal1 in mice promotes PGE2 synthesis by up-regulating Ptgs2 in response to increases in E2 on D4 of pregnancy.	Estradiol	55-57	basic helix-loop-helix ARNT like 1	Mus musculus	30-35
33790796-4	2021	In our study, Bmal1 was detected to be low expressed in EtOH-fed mice tissue samples and ethanol-induced RAW264.7 cells.	Ethanol	56-60	basic helix-loop-helix ARNT like 1	Mus musculus	14-19
33790796-4	2021	In our study, Bmal1 was detected to be low expressed in EtOH-fed mice tissue samples and ethanol-induced RAW264.7 cells.	Ethanol	89-96	basic helix-loop-helix ARNT like 1	Mus musculus	14-19
33790796-6	2021	Furthermore, alcoholic liver lesions were also improved in alcohol feeding mice with overexpressed Bmal1.	Alcohols	13-20	basic helix-loop-helix ARNT like 1	Mus musculus	99-104
33687272-8	2021	DEX treatment increased or rescued hGH-N RNA levels, and was associated with elevated Bmal1 transcripts when assessed 12 h after final treatment, and at a time when serum corticosterone levels were suppressed >90%.	Dexamethasone	0-3	basic helix-loop-helix ARNT like 1	Mus musculus	86-91
33652118-8	2021	Functionally, Breg cells highly expressing PDL1 in intestinal intraepithelial lymphocytes (IEL)helped to alleviate severity of colitis after DSS treatment and was dysregulated in DSS-treated Bmal1-/- mice.	Dextran Sulfate	179-182	basic helix-loop-helix ARNT like 1	Mus musculus	191-196
33652118-10	2021	Dysregulated PDL1+B cells induced cell death of activated CD4+ T cells in DSS-treated Bmal1-/- mice.	Dextran Sulfate	74-77	basic helix-loop-helix ARNT like 1	Mus musculus	86-91
33598947-0	2021	Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis-related gene transcription in goat Leydig cells.	Testosterone	36-48	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
33598947-7	2021	Several Bmal1-Luc circadian oscillations were clearly observed in dexamethasone-treated goat LCs transfected with the pLV6-Bmal1-Luc plasmid.	Dexamethasone	66-79	basic helix-loop-helix ARNT like 1	Mus musculus	8-13
33598947-7	2021	Several Bmal1-Luc circadian oscillations were clearly observed in dexamethasone-treated goat LCs transfected with the pLV6-Bmal1-Luc plasmid.	Dexamethasone	66-79	basic helix-loop-helix ARNT like 1	Mus musculus	123-128
33598947-8	2021	BMAL1 knockdown significantly downregulated mRNA levels of PER2, NR1D1, DBP, StAR, HSD3B2, SF1, NUR77, and GATA4, and dramatically decreased StAR and HSD3B2 protein levels and testosterone production.	Testosterone	176-188	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
33598947-9	2021	In contrast, BMAL1 overexpression significantly increased the mRNA and protein expression levels of StAR and HSD17B3 and enhanced testosterone production.	Testosterone	130-142	basic helix-loop-helix ARNT like 1	Mus musculus	13-18
33598947-11	2021	These data indicate that BMAL1 contributes to testosterone production by regulating transcription of steroidogenesis-related genes in goat LCs, providing a basis for further exploring the underlying mechanism by which the circadian clock regulates ruminant reproductive capability.	Testosterone	46-58	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
33525630-4	2021	The intracellular polyamines exhibited a rhythm with a period of about 24 h. In the polyamine-reduced NIH3T3 cells, the circadian period of circadian clock genes was lengthened and the synthesis of BMAL1 and REV-ERBalpha was significantly reduced at the translation level.	Polyamines	18-28	basic helix-loop-helix ARNT like 1	Mus musculus	198-203
33525630-5	2021	Thus, the mechanism of polyamine stimulation of these protein syntheses was analyzed using NIH3T3 cells transiently transfected with genes encoding enhanced green fluorescent protein (EGFP) fusion mRNA with normal or mutated 5"-untranslated region (5"-UTR) of Bmal1 or Rev-erbalpha mRNA.	Polyamines	23-32	basic helix-loop-helix ARNT like 1	Mus musculus	260-265
33525630-6	2021	It was found that polyamines stimulated BMAL1 and REV-ERBalpha synthesis through the enhancement of ribosomal shunting during the ribosome shunting within the 5"-UTR of mRNAs.	Polyamines	18-28	basic helix-loop-helix ARNT like 1	Mus musculus	40-45
33297044-6	2021	BPA treatment also significantly downregulated NR1D1 and StAR protein expression, but upregulated BMAL1 protein expression in TM3 cells.	bisphenol A	0-3	basic helix-loop-helix ARNT like 1	Mus musculus	98-103
33297044-8	2021	Intraperitoneal injection of BPA profoundly reduced NR1D1 and StAR protein levels and steroidogenic gene transcription levels (Cyp11a1, Hsd3b2, and Hsd17b3), while enhancing BMAL1 protein and other circadian clock gene (Per2 and Dbp) levels in mouse testes.	bisphenol A	29-32	basic helix-loop-helix ARNT like 1	Mus musculus	174-179
33363534-8	2020	These changes were also observed in Bmal1 knock-down microglial BV-2 cells under lipopolysaccharide (LPS) and palmitic acid stimulations.	Palmitic Acid	110-123	basic helix-loop-helix ARNT like 1	Mus musculus	36-41
33112769-8	2020	After PI3K specific-inhibitor LY294002 intervention, mRNA expressions of Lhcgr and Hsd32 were partially-rescued in Bmal1 interference TCs, together with significantly increased androstenedione and T synthesis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	basic helix-loop-helix ARNT like 1	Mus musculus	115-120
32739676-0	2020	Involvement of Bmal1 and circadian clock signaling in chondrogenic differentiation of ATDC5 cells by fluoride.	Fluorides	101-109	basic helix-loop-helix ARNT like 1	Mus musculus	15-20
32739676-6	2020	Meanwhile, fluoride significantly inhibited the expression of Bmal1 and disrupted circadian clock signaling pathway (P < 0.05).	Fluorides	11-19	basic helix-loop-helix ARNT like 1	Mus musculus	62-67
32739676-8	2020	Overexpression of Bmal1 by lentivirus reversed the adverse effects of fluoride on chondrogenesis.	Fluorides	70-78	basic helix-loop-helix ARNT like 1	Mus musculus	18-23
32739676-10	2020	Fluoride delayed chondrogenesis partly via interfering with Bmal1 and circadian clock signaling pathway.	Fluorides	0-8	basic helix-loop-helix ARNT like 1	Mus musculus	60-65
33121486-5	2020	Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice.	Water	101-106	basic helix-loop-helix ARNT like 1	Mus musculus	193-198
33013449-6	2020	Alcohol significantly dampened diurnal rhythms of mRNA levels in clock genes Bmal1 and Dbp, phase advanced Nr1d1/REV-ERBalpha, and induced arrhythmicity in Clock, Noct, and Nfil3/E4BP4, with further disruption in livers of LKO mice.	Alcohols	0-7	basic helix-loop-helix ARNT like 1	Mus musculus	77-82
32784474-8	2020	Intriguingly, Bmal1/Nrf2/Prdx6 and PhaseII antioxidants showed rhythmic expression in mouse lenses in vivo and were reciprocally linked to ROS levels.	Reactive Oxygen Species	139-142	basic helix-loop-helix ARNT like 1	Mus musculus	14-19
32305634-0	2020	BMAL1 knockdown promoted apoptosis and reduced testosterone secretion in TM3 Leydig cell line.	Testosterone	47-59	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
32305634-4	2020	BMAL1 inhibition resulted in decreased testosterone secretion and reduced expression of key genes during hormone synthesis, specifically steroidogenic acute regulatory protein (STAR), cytochrome P450 family 11 subfamily A member 1 (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD).	Testosterone	39-51	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
32305634-6	2020	In conclusion, BMAL1 may affect testosterone secretion and apoptosis in mouse Leydig cells through regulation of the PI3K/AKT signaling pathway.	Testosterone	32-44	basic helix-loop-helix ARNT like 1	Mus musculus	15-20
32522976-4	2020	In our present study, we demonstrated that Bmal1, as a key clock gene, was induced by the cisplatin stimulation in the mouse kidney and cultured human HK-2 renal cells.	Cisplatin	90-99	basic helix-loop-helix ARNT like 1	Mus musculus	43-48
32369735-4	2020	In old mice, dampened BMAL1 chromatin binding, transcriptional oscillations, mitochondrial respiration rhythms, and late evening activity are restored by NAD+ repletion to youthful levels with NR.	NAD	154-158	basic helix-loop-helix ARNT like 1	Mus musculus	22-27
32338037-0	2020	Differences in renal BMAL1 contribution to sodium homeostasis and blood pressure control in male and female mice.	Sodium	43-49	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32338037-7	2020	In addition, male KS-BMAL1 KO had less sodium retention compared to CNTL in response to a potassium-restricted diet (15% less following 5 days of treatment).	Sodium	39-45	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32338037-7	2020	In addition, male KS-BMAL1 KO had less sodium retention compared to CNTL in response to a potassium-restricted diet (15% less following 5 days of treatment).	Potassium	90-99	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32338037-10	2020	We propose that BMAL1 in the distal nephron and collecting duct contributes to blood pressure regulation and sodium handling in a sex-specific manner.	Sodium	109-115	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
31833591-4	2020	Here, we show that astrocyte-specific deletion of Bmal1 is sufficient to alter energy balance, glucose homeostasis, and reduce lifespan.	Glucose	95-102	basic helix-loop-helix ARNT like 1	Mus musculus	50-55
32396064-4	2020	Upon M1 stimulation, myeloid-specific Bmal1 knockout (M-BKO) renders macrophages unable to sustain mitochondrial function, enhancing succinate dehydrogenase (SDH)-mediated mitochondrial ROS production and Hif-1a-dependent metabolic reprogramming and inflammatory damage.	ros	186-189	basic helix-loop-helix ARNT like 1	Mus musculus	38-43
32115146-6	2020	These Arntl-deficient mice developed l-arginine-induced acute pancreatitis more rapidly than controls, with increased mortality, tissue injury, neutrophil infiltration, and HMGB1 release.	Arginine	37-47	basic helix-loop-helix ARNT like 1	Mus musculus	6-11
32115146-7	2020	In contrast, the administration of liproxstatin-1 (a ferroptosis inhibitor) or anti-HMGB1 neutralizing antibody attenuated the development of acute pancreatitis in the Arntl-deficient mice.	liproxstatin-1	35-49	basic helix-loop-helix ARNT like 1	Mus musculus	168-173
32212194-7	2020	Notably, the loss of Bmal1 response to feeding abolished fasting-to-feeding metabolic fuel switch from fatty acids to glucose in skeletal muscle, leading to the activation of energy-sensing pathways for fatty acid oxidation.	Fatty Acids	103-114	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32212194-7	2020	Notably, the loss of Bmal1 response to feeding abolished fasting-to-feeding metabolic fuel switch from fatty acids to glucose in skeletal muscle, leading to the activation of energy-sensing pathways for fatty acid oxidation.	Glucose	118-125	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32212194-7	2020	Notably, the loss of Bmal1 response to feeding abolished fasting-to-feeding metabolic fuel switch from fatty acids to glucose in skeletal muscle, leading to the activation of energy-sensing pathways for fatty acid oxidation.	Fatty Acids	103-113	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
32246801-0	2020	BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinson"s disease mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	60-64	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine	76-120	basic helix-loop-helix ARNT like 1	Mus musculus	36-64
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine	76-120	basic helix-loop-helix ARNT like 1	Mus musculus	66-71
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	122-126	basic helix-loop-helix ARNT like 1	Mus musculus	36-64
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	122-126	basic helix-loop-helix ARNT like 1	Mus musculus	66-71
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	Dopamine	195-203	basic helix-loop-helix ARNT like 1	Mus musculus	36-64
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	Dopamine	195-203	basic helix-loop-helix ARNT like 1	Mus musculus	66-71
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	Dopamine	217-219	basic helix-loop-helix ARNT like 1	Mus musculus	36-64
32246801-2	2020	We here showed that inactivation of brain and muscle ARNT-like 1 (BMAL1) in 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted in obvious motor functional deficit, loss of dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNpc), decrease of dopamine (DA) transmitter, and increased activation of microglia and astrocytes in the striatum.	Dopamine	217-219	basic helix-loop-helix ARNT like 1	Mus musculus	66-71
32246801-3	2020	Time on the rotarod or calorie consumption, and food and water intake were reduced in the Bmal1-/- mice after MPTP treatment, suggesting that absence of Bmal1 may exacerbate circadian and PD motor function.	Water	57-62	basic helix-loop-helix ARNT like 1	Mus musculus	90-95
32246801-3	2020	Time on the rotarod or calorie consumption, and food and water intake were reduced in the Bmal1-/- mice after MPTP treatment, suggesting that absence of Bmal1 may exacerbate circadian and PD motor function.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	110-114	basic helix-loop-helix ARNT like 1	Mus musculus	90-95
32246801-6	2020	These findings suggest that BMAL1 may play an essential role in the survival of DANs and maintain normal function of the DA signaling pathway via regulating microglia-mediated neuroinflammation in the brain.	Dopamine	80-82	basic helix-loop-helix ARNT like 1	Mus musculus	28-33
32114021-7	2020	Furthermore, palmitate increased BMAL1 binding to the Npy promotor region, and palmitate treatment (50 muM for 24 h) stimulated Npy expression in a BMAL1-dependent manner in both heterogeneous and clonal NPY-expressing female-derived cell models.	Palmitates	13-22	basic helix-loop-helix ARNT like 1	Mus musculus	33-38
32114021-7	2020	Furthermore, palmitate increased BMAL1 binding to the Npy promotor region, and palmitate treatment (50 muM for 24 h) stimulated Npy expression in a BMAL1-dependent manner in both heterogeneous and clonal NPY-expressing female-derived cell models.	Palmitates	79-88	basic helix-loop-helix ARNT like 1	Mus musculus	148-153
32114021-8	2020	The results of this study demonstrate that circadian expression of Bmal1 serves as a mechanistic link between Western diet- and palmitate-induced disruptions of the normal rhythmic patterns in hypothalamic feeding-related neuropeptides.	Palmitates	128-137	basic helix-loop-helix ARNT like 1	Mus musculus	67-72
31958455-5	2020	Pretreatment with diphenyleneiodonium (an NADPH oxidase inhibitor) and U0126 or PD98059 (MEK Inhibitors) inhibited PDGF-BB-induced BMAL1 expression in a dose-dependent manner in VSMCs.	diphenyleneiodonium	18-37	basic helix-loop-helix ARNT like 1	Mus musculus	131-136
31958455-5	2020	Pretreatment with diphenyleneiodonium (an NADPH oxidase inhibitor) and U0126 or PD98059 (MEK Inhibitors) inhibited PDGF-BB-induced BMAL1 expression in a dose-dependent manner in VSMCs.	NADP	42-47	basic helix-loop-helix ARNT like 1	Mus musculus	131-136
31958455-5	2020	Pretreatment with diphenyleneiodonium (an NADPH oxidase inhibitor) and U0126 or PD98059 (MEK Inhibitors) inhibited PDGF-BB-induced BMAL1 expression in a dose-dependent manner in VSMCs.	U 0126	71-76	basic helix-loop-helix ARNT like 1	Mus musculus	131-136
31958455-5	2020	Pretreatment with diphenyleneiodonium (an NADPH oxidase inhibitor) and U0126 or PD98059 (MEK Inhibitors) inhibited PDGF-BB-induced BMAL1 expression in a dose-dependent manner in VSMCs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	80-87	basic helix-loop-helix ARNT like 1	Mus musculus	131-136
31958455-7	2020	The results demonstrate that PDGF-BB up-regulates BMAL1 expression through reactive oxygen species/ERK/Egr-1 pathways and that BMAL1 is involved in PDGF-BB-induced cell proliferation partially through ERK in VSMCs.	Oxygen	84-90	basic helix-loop-helix ARNT like 1	Mus musculus	50-55
31931676-8	2020	In the intraperitoneal macrophages, DOX increased Clock (ZT10), Rev-Erbalpha (ZT18 and ZT22) and Per2 expressions (ZT18); in the LLC+DOX group was increased Bmal1 (ZT10), Per2 (ZT18) and NF-kB (ZT22) expressions; IL-6 expression increased in the LCC group (ZT02).	Doxorubicin	36-39	basic helix-loop-helix ARNT like 1	Mus musculus	157-162
31931676-8	2020	In the intraperitoneal macrophages, DOX increased Clock (ZT10), Rev-Erbalpha (ZT18 and ZT22) and Per2 expressions (ZT18); in the LLC+DOX group was increased Bmal1 (ZT10), Per2 (ZT18) and NF-kB (ZT22) expressions; IL-6 expression increased in the LCC group (ZT02).	Doxorubicin	133-136	basic helix-loop-helix ARNT like 1	Mus musculus	157-162
32269528-10	2020	In addition, ethanol-induced increases in levels of brain and muscle arnt-like protein-1 (BMAL1), circadian locomotor output cycles kaput (CLOCK), and period 2 (PER2) were reversed by 40-Hz light flicker.	Ethanol	13-20	basic helix-loop-helix ARNT like 1	Mus musculus	52-88
32269528-10	2020	In addition, ethanol-induced increases in levels of brain and muscle arnt-like protein-1 (BMAL1), circadian locomotor output cycles kaput (CLOCK), and period 2 (PER2) were reversed by 40-Hz light flicker.	Ethanol	13-20	basic helix-loop-helix ARNT like 1	Mus musculus	90-95
31904281-2	2020	A high-salt diet induces a phase shift in Bmal1 expression in the renal inner medulla that is dependent on endothelin type B (ETB) receptors.	Salts	7-11	basic helix-loop-helix ARNT like 1	Mus musculus	42-47
32092990-6	2020	In Bmal1 fKO mice, oxidative stress was increased in subregions of the hippocampus and the olfactory bulb but not in the neurogenic niches.	3-(2-Chlorophenyl)-6-(2-Fluorophenoxy)-2h-Indazole	9-12	basic helix-loop-helix ARNT like 1	Mus musculus	3-8
31800167-6	2020	Interestingly, pharmacological inhibition of REV-ERBs with the small molecule antagonist SR8278 or genetic knockdown of REV-ERBs-accelerated microglial uptake of fAbeta1-42 and increased transcription of BMAL1.	SR 8278	89-95	basic helix-loop-helix ARNT like 1	Mus musculus	204-209
31866303-6	2020	Berberine significantly inhibited Bmal1 (-2000/+100 bp)- and Nlrp3 (-1310/+100 bp)-Luc reporter activities, and dose-dependently decreased cellular expressions of both Bmal1 and Nlrp3.	Berberine	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	34-39
31866303-6	2020	Berberine significantly inhibited Bmal1 (-2000/+100 bp)- and Nlrp3 (-1310/+100 bp)-Luc reporter activities, and dose-dependently decreased cellular expressions of both Bmal1 and Nlrp3.	Berberine	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	168-173
31911401-13	2020	In addition, Bmal1 ablation increased the plasma concentrations of AC, HA and MA in mice after oral gavage of Fuzi, and reduced formation of their metabolites (N-deethyl-AC, didemethyl-HA and 2-hydroxyl-MA).	hypaconitine	71-73	basic helix-loop-helix ARNT like 1	Mus musculus	13-18
31911401-13	2020	In addition, Bmal1 ablation increased the plasma concentrations of AC, HA and MA in mice after oral gavage of Fuzi, and reduced formation of their metabolites (N-deethyl-AC, didemethyl-HA and 2-hydroxyl-MA).	n-deethyl-ac	160-172	basic helix-loop-helix ARNT like 1	Mus musculus	13-18
31911401-13	2020	In addition, Bmal1 ablation increased the plasma concentrations of AC, HA and MA in mice after oral gavage of Fuzi, and reduced formation of their metabolites (N-deethyl-AC, didemethyl-HA and 2-hydroxyl-MA).	didemethyl-ha	174-187	basic helix-loop-helix ARNT like 1	Mus musculus	13-18
31911401-13	2020	In addition, Bmal1 ablation increased the plasma concentrations of AC, HA and MA in mice after oral gavage of Fuzi, and reduced formation of their metabolites (N-deethyl-AC, didemethyl-HA and 2-hydroxyl-MA).	2-hydroxyl-ma	192-205	basic helix-loop-helix ARNT like 1	Mus musculus	13-18
32019183-9	2020	Furthermore, we found that loss of Bmal1 was associated with the accumulation of Reactive Oxygen Species Modulator 1 (ROMO1), a protein responsible for inducing the production of intracellular reactive oxygen species (ROS).	Oxygen	202-208	basic helix-loop-helix ARNT like 1	Mus musculus	35-40
31900362-6	2020	BMAL1-/- macrophages exhibited marked differences in actin cytoskeletal organization, a phosphoproteome enriched for cytoskeletal changes, with reduced phosphocofilin and increased active RhoA.	phosphocofilin	152-166	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
31768571-8	2020	The mechanism behind DOX interference with the circadian clock was further studied in vitro, in which were observed alterations of circadian-gene expression and increased BMAL1 SIRT1-mediated deacetylation.	Doxorubicin	21-24	basic helix-loop-helix ARNT like 1	Mus musculus	171-176
32741824-4	2020	In addition, we also assessed the effect of melatonin pre-treatment in vitro before amyloid-beta stimulus in the daily pattern of brain and muscle Arnt-like protein 1 (Bmal1) expression.	Melatonin	44-53	basic helix-loop-helix ARNT like 1	Mus musculus	130-166
32741824-4	2020	In addition, we also assessed the effect of melatonin pre-treatment in vitro before amyloid-beta stimulus in the daily pattern of brain and muscle Arnt-like protein 1 (Bmal1) expression.	Melatonin	44-53	basic helix-loop-helix ARNT like 1	Mus musculus	168-173
32741824-6	2020	Besides, a significant circadian pattern of Bmal1 occurs in the intermittent melatonin pre-treatment group, showing that melatonin can reset the CP circadian clock.	Melatonin	77-86	basic helix-loop-helix ARNT like 1	Mus musculus	44-49
32741824-6	2020	Besides, a significant circadian pattern of Bmal1 occurs in the intermittent melatonin pre-treatment group, showing that melatonin can reset the CP circadian clock.	Melatonin	121-130	basic helix-loop-helix ARNT like 1	Mus musculus	44-49
31791161-6	2019	Palmitate-induced AKT and GSK3beta activation led to the phosphorylation of BMAL1 that resulted in low levels as well as high amplitude of circadian clock expression.	Palmitates	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	76-81
31588796-6	2019	Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1.	Corticosterone	0-14	basic helix-loop-helix ARNT like 1	Mus musculus	153-214
31585206-5	2019	In this study, we found that the protein expression of circadian genes Clock, Bmal1, Per1/2, and Cry1/2 in NIH3T3 cells was upregulated by hydrogen peroxide (H2O2), an important mediator of oxidative stress.	Hydrogen Peroxide	139-156	basic helix-loop-helix ARNT like 1	Mus musculus	78-83
31585206-5	2019	In this study, we found that the protein expression of circadian genes Clock, Bmal1, Per1/2, and Cry1/2 in NIH3T3 cells was upregulated by hydrogen peroxide (H2O2), an important mediator of oxidative stress.	Water	158-162	basic helix-loop-helix ARNT like 1	Mus musculus	78-83
31585206-6	2019	In addition, H2O2 modulated the circadian rhythm of Bmal1-luciferase via RORalpha, REV-ERBalpha (NR1D1), and REV-ERBbeta (NR1D2).	Water	13-17	basic helix-loop-helix ARNT like 1	Mus musculus	52-57
31472126-14	2019	Intestinal ablation of Bmal1 exacerbated oleandrin toxicity and enhanced drug exposure.	oleandrin	41-50	basic helix-loop-helix ARNT like 1	Mus musculus	23-28
31633069-8	2019	Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure.	Aconitine	64-73	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
31633069-8	2019	Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure.	triptolide	78-88	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
31398249-11	2019	These observations underscore a role for adrenal Bmal1 as an attenuator of steroid secretion that is most prominent in female mice.	Steroids	75-82	basic helix-loop-helix ARNT like 1	Mus musculus	49-54
31351068-8	2019	Inhibition (siRNA/pharmacological inhibitors) of both CSE and GCLC (the rate-limiting enzyme in GSH biosynthesis) decreased H2S, and increased OS; Bmal1 and Clock mRNA levels were downregulated, while Rev-erbalpha increased significantly in these conditions.	Glutathione	96-99	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
31382467-6	2019	In contrast, two weeks after STZ treatment, mice showed increases in the blood glucose level, decreases in AQP3, Bmal1, Clock, and Dbp levels, and increases in the urinary levels of 8-OHdG.	Streptozocin	29-32	basic helix-loop-helix ARNT like 1	Mus musculus	113-118
31150629-10	2019	Moreover, Bmal1 ablation in mice abolished the daily rhythm of Cyp3a11 expression and abrogated the time-dependency of hypaconitine toxicity.	hypaconitine	119-131	basic helix-loop-helix ARNT like 1	Mus musculus	10-15
31294688-4	2019	During the activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcriptional activator BMAL1 leading to recruitment of BRD4 and the pause release factor P-TEFb, followed by productive elongation of circadian transcripts.	Lysine	56-62	basic helix-loop-helix ARNT like 1	Mus musculus	128-133
31410205-0	2019	Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia.	Bilirubin	37-46	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
31410205-10	2019	Bmal1 ablation abrogated the circadian rhythms of UCB and bilirubin-induced hepatotoxicity in mice.	Bilirubin	58-67	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
31410205-13	2019	Further, Bmal1 ablation caused a loss of circadian time-dependency in bilirubin clearance and sensitized mice to chemical induced-hyperbilirubinemia.	Bilirubin	70-79	basic helix-loop-helix ARNT like 1	Mus musculus	9-14
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	10-19	basic helix-loop-helix ARNT like 1	Mus musculus	31-36
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	121-130	basic helix-loop-helix ARNT like 1	Mus musculus	31-36
31005255-6	2019	LY2857785 treatment, as well as Cdk9 knock-down, led to lowered expression of Bmal1 in accordance with elevated expression of Rev-Erbalpha.	N1-(4-(3-isopropyl-2-methylindazol-5-yl)pyrimidin-2-yl)-N4-tetrahydropyran-4-yl-cyclohexane-1,4-diamine	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	78-83
30694347-7	2019	Palmitate, but not oleate, counteracted the reduction in lipid accumulation and BMAL1-induced expression of mitochondrial genes involved in fatty acid oxidation.	Palmitates	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	80-85
30694347-7	2019	Palmitate, but not oleate, counteracted the reduction in lipid accumulation and BMAL1-induced expression of mitochondrial genes involved in fatty acid oxidation.	Fatty Acids	140-150	basic helix-loop-helix ARNT like 1	Mus musculus	80-85
30694347-8	2019	Palmitate was also found to interfere with the transcriptional activity of CLOCK:BMAL1 by preventing BMAL1 deacetylation and activation.	Palmitates	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	81-86
30694347-8	2019	Palmitate was also found to interfere with the transcriptional activity of CLOCK:BMAL1 by preventing BMAL1 deacetylation and activation.	Palmitates	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	101-106
30694347-9	2019	In addition, palmitate, but not oleate, reduced PER2-mediated transcriptional activation and increased REV-ERBalpha-mediated transcriptional inhibition of Bmal1.	Palmitates	13-22	basic helix-loop-helix ARNT like 1	Mus musculus	155-160
30703445-5	2019	The ER stress activators thapsigargin (Tg) and tunicamycin (Tm) markedly reduced Bmal1-Luc oscillation amplitudes and induced phase delay shifts in NIH3T3 cells.	Thapsigargin	25-37	basic helix-loop-helix ARNT like 1	Mus musculus	81-86
30703445-5	2019	The ER stress activators thapsigargin (Tg) and tunicamycin (Tm) markedly reduced Bmal1-Luc oscillation amplitudes and induced phase delay shifts in NIH3T3 cells.	Thapsigargin	39-41	basic helix-loop-helix ARNT like 1	Mus musculus	81-86
30703445-5	2019	The ER stress activators thapsigargin (Tg) and tunicamycin (Tm) markedly reduced Bmal1-Luc oscillation amplitudes and induced phase delay shifts in NIH3T3 cells.	Tunicamycin	47-58	basic helix-loop-helix ARNT like 1	Mus musculus	81-86
30703445-5	2019	The ER stress activators thapsigargin (Tg) and tunicamycin (Tm) markedly reduced Bmal1-Luc oscillation amplitudes and induced phase delay shifts in NIH3T3 cells.	Tunicamycin	60-62	basic helix-loop-helix ARNT like 1	Mus musculus	81-86
30703445-7	2019	4-Phenylbutyric acid, an ER stress inhibitor, alleviated the transcriptional repression of the circadian clock genes and partially restored Bmal1-Luc oscillation amplitudes in Tg- or Tm-treated NIH3T3 cells.	4-phenylbutyric acid	0-20	basic helix-loop-helix ARNT like 1	Mus musculus	140-145
30659651-7	2019	In adipocytes, we identified melatonin to reduce the production of resistin through the brain and muscle arnt-like protein 1 (Bmal1) transcriptional inhibition.	Melatonin	29-38	basic helix-loop-helix ARNT like 1	Mus musculus	88-124
30659651-7	2019	In adipocytes, we identified melatonin to reduce the production of resistin through the brain and muscle arnt-like protein 1 (Bmal1) transcriptional inhibition.	Melatonin	29-38	basic helix-loop-helix ARNT like 1	Mus musculus	126-131
31015483-3	2019	TCDD diminished the rhythmicity of several core clock regulators (e.g. Arntl, Clock, Nr1d1, Per1, Cry1, Nfil3) in a dose-dependent manner, involving either a >= 3.3-fold suppression in amplitude or complete loss of oscillation.	Polychlorinated Dibenzodioxins	0-4	basic helix-loop-helix ARNT like 1	Mus musculus	71-76
31244920-10	2019	Bmal1 ablation caused reductions in Mrp2 mRNA and protein levels [as well as in transport activity (measured by MTX)], and blunted their diurnal rhythms.	Methotrexate	112-115	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
31244920-11	2019	Intestinal ablation of Bmal1 abrogated circadian time-dependency of MTX pharmacokinetics and toxicity.	Methotrexate	68-71	basic helix-loop-helix ARNT like 1	Mus musculus	23-28
30973828-1	2019	Recently, by utilizing conventional and tamoxifen inducible Bmal1 (Brain and muscle Arnt-like protein 1) knockout mice, we found that delaying the loss of circadian rhythms to adulthood attenuates the impact on general integrity and survival at least under 12h light/12h dark conditions (LD).	Tamoxifen	40-49	basic helix-loop-helix ARNT like 1	Mus musculus	60-65
30973828-1	2019	Recently, by utilizing conventional and tamoxifen inducible Bmal1 (Brain and muscle Arnt-like protein 1) knockout mice, we found that delaying the loss of circadian rhythms to adulthood attenuates the impact on general integrity and survival at least under 12h light/12h dark conditions (LD).	Tamoxifen	40-49	basic helix-loop-helix ARNT like 1	Mus musculus	67-103
29795456-0	2019	Rosiglitazone reverses high fat diet-induced changes in BMAL1 function in muscle, fat, and liver tissue in mice.	Rosiglitazone	0-13	basic helix-loop-helix ARNT like 1	Mus musculus	56-61
29795456-7	2019	Restoring whole body insulin sensitivity by treatment with the antidiabetic drug rosiglitazone is sufficient to restore changes in HF diet-induced BMAL1 recruitment and activity in several tissues.	Rosiglitazone	81-94	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
30889551-10	2019	Chronobiological analysis of synchronized C3H mouse chondrocytes revealed that melatonin induced the cyclic expression of Aanat and modified the cyclic rhythm of Bmal1, Mt1, and Mt2.	Melatonin	79-88	basic helix-loop-helix ARNT like 1	Mus musculus	162-167
30811401-6	2019	We further showed a significant yet differential effect on expression levels of core clock and clock-controlled genes (Bmal1, Per2) in the lungs of mice exposed to e-cig vapor containing nicotine.	Nicotine	187-195	basic helix-loop-helix ARNT like 1	Mus musculus	119-124
30341743-4	2019	In isolated NPCs from Bmal1-/- mice, not only migration velocity and expression pattern of genes involved in detoxification of reactive oxygen species were affected, but also RNA oxidation of catalase was increased and catalase protein levels were decreased.	Reactive Oxygen Species	127-150	basic helix-loop-helix ARNT like 1	Mus musculus	22-27
30341743-5	2019	Bmal1+/+ migration phenotype could be restored by treatment with catalase, while treatment of NPCs from Bmal1+/+ mice with hydrogen peroxide mimicked Bmal1-/- migration phenotype.	Hydrogen Peroxide	123-140	basic helix-loop-helix ARNT like 1	Mus musculus	104-109
30341743-5	2019	Bmal1+/+ migration phenotype could be restored by treatment with catalase, while treatment of NPCs from Bmal1+/+ mice with hydrogen peroxide mimicked Bmal1-/- migration phenotype.	Hydrogen Peroxide	123-140	basic helix-loop-helix ARNT like 1	Mus musculus	104-109
30217816-9	2018	Moreover, the GSK-3beta inhibitor lithium or siRNA-mediated GSK-3beta knockdown diminished the effects of IGF-1 on the Bmal-1 promoter.	Lithium	34-41	basic helix-loop-helix ARNT like 1	Mus musculus	119-125
30117209-2	2018	In this study, BMAL1 deficiency leads to SMH formation, and we aim to investigate the mechanism by which BMAL1 deficiency induces SMH.	N-(2-Ethoxyethyl)-N-{(2s)-2-Hydroxy-3-[(2r)-6-Hydroxy-4-Oxo-3,4-Dihydro-1'h-Spiro[chromene-2,3'-Piperidin]-1'-Yl]propyl}-2,6-Dimethylbenzenesulfonamide	41-44	basic helix-loop-helix ARNT like 1	Mus musculus	15-20
30117209-2	2018	In this study, BMAL1 deficiency leads to SMH formation, and we aim to investigate the mechanism by which BMAL1 deficiency induces SMH.	N-(2-Ethoxyethyl)-N-{(2s)-2-Hydroxy-3-[(2r)-6-Hydroxy-4-Oxo-3,4-Dihydro-1'h-Spiro[chromene-2,3'-Piperidin]-1'-Yl]propyl}-2,6-Dimethylbenzenesulfonamide	130-133	basic helix-loop-helix ARNT like 1	Mus musculus	105-110
30231537-10	2018	We thus conclude that BMAL1 is a critical regulator of the muscular fatty acid level under nutrition overloading and that the mechanism involves the control of oxidative capacity.	Fatty Acids	68-78	basic helix-loop-helix ARNT like 1	Mus musculus	22-27
29534306-4	2018	Ethanol diet-fed mice with liver-specific knockout (Bmal1-LKO) or depletion of Bmal1 develop more severe liver steatosis and injury as well as a simultaneous suppression of both de novo lipogenesis and fatty acid oxidation, which can be rescued by the supplementation of synthetic PPARalpha ligands.	Ethanol	0-7	basic helix-loop-helix ARNT like 1	Mus musculus	52-57
29534306-5	2018	Restoring de novo lipogenesis in the liver of Bmal1-LKO mice by constitutively active AKT not only elevates hepatic fatty acid oxidation but also alleviates ethanol-induced fatty liver and liver injury.	Fatty Acids	116-126	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
29534306-5	2018	Restoring de novo lipogenesis in the liver of Bmal1-LKO mice by constitutively active AKT not only elevates hepatic fatty acid oxidation but also alleviates ethanol-induced fatty liver and liver injury.	Ethanol	157-164	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
29534306-6	2018	Furthermore, hepatic over-expression of lipogenic transcription factor ChREBP, but not SREBP-1c, in the liver of Bmal1-LKO mice also increases fatty acid oxidation and partially reduces ethanol-induced fatty liver and liver injury.	Fatty Acids	143-153	basic helix-loop-helix ARNT like 1	Mus musculus	113-118
29534306-6	2018	Furthermore, hepatic over-expression of lipogenic transcription factor ChREBP, but not SREBP-1c, in the liver of Bmal1-LKO mice also increases fatty acid oxidation and partially reduces ethanol-induced fatty liver and liver injury.	Ethanol	186-193	basic helix-loop-helix ARNT like 1	Mus musculus	113-118
29534306-8	2018	The protective action of BMAL1 during alcohol consumption depends on its ability to couple ChREBP-induced de novo lipogenesis with PPARalpha-mediated fatty oxidation.	Alcohols	38-45	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
30115857-8	2018	Metronidazole in germ-free (GF) mice increases the expression of other core clock genes, such as Bmal1 and Per2, as well as the metabolic regulators FoxO1 and Pdk4, suggesting a microbiota-independent pharmacologic effect.	Metronidazole	0-13	basic helix-loop-helix ARNT like 1	Mus musculus	97-102
30096135-6	2018	Accordingly, muscle-specific loss of BMAL1 is associated with metabolic inefficiency, impaired muscle triglyceride biosynthesis, and accumulation of bioactive lipids and amino acids.	Triglycerides	102-114	basic helix-loop-helix ARNT like 1	Mus musculus	37-42
29989105-7	2018	The Casein Kinase 1epsilon/delta inhibitor (PF670462) administration, which is a Clock/Bmal1 inhibitor (PER2 activator), inhibited the deterioration caused by UVB eye irradiation.	PF-670462	44-52	basic helix-loop-helix ARNT like 1	Mus musculus	87-92
29437576-3	2018	APPROACH AND RESULTS: SMC-selective deletion of BMAL1 potently protected mice from AAA induced by (1) MR (mineralocorticoid receptor) agonist deoxycorticosterone acetate or aldosterone plus high salt intake and (2) angiotensin II infusion in hypercholesterolemia mice.	Desoxycorticosterone Acetate	142-169	basic helix-loop-helix ARNT like 1	Mus musculus	48-53
29437576-3	2018	APPROACH AND RESULTS: SMC-selective deletion of BMAL1 potently protected mice from AAA induced by (1) MR (mineralocorticoid receptor) agonist deoxycorticosterone acetate or aldosterone plus high salt intake and (2) angiotensin II infusion in hypercholesterolemia mice.	Aldosterone	173-184	basic helix-loop-helix ARNT like 1	Mus musculus	48-53
29437576-3	2018	APPROACH AND RESULTS: SMC-selective deletion of BMAL1 potently protected mice from AAA induced by (1) MR (mineralocorticoid receptor) agonist deoxycorticosterone acetate or aldosterone plus high salt intake and (2) angiotensin II infusion in hypercholesterolemia mice.	Salts	195-199	basic helix-loop-helix ARNT like 1	Mus musculus	48-53
29437576-4	2018	Aortic BMAL1 was upregulated by deoxycorticosterone acetate-salt, and deletion of BMAL1 in SMCs selectively upregulated TIMP4 (tissue inhibitor of metalloproteinase 4) and suppressed deoxycorticosterone acetate-salt-induced MMP (matrix metalloproteinase) activation and elastin breakages.	deoxycorticosterone acetate-salt	32-64	basic helix-loop-helix ARNT like 1	Mus musculus	7-12
29437576-4	2018	Aortic BMAL1 was upregulated by deoxycorticosterone acetate-salt, and deletion of BMAL1 in SMCs selectively upregulated TIMP4 (tissue inhibitor of metalloproteinase 4) and suppressed deoxycorticosterone acetate-salt-induced MMP (matrix metalloproteinase) activation and elastin breakages.	Desoxycorticosterone Acetate	32-59	basic helix-loop-helix ARNT like 1	Mus musculus	7-12
29437576-4	2018	Aortic BMAL1 was upregulated by deoxycorticosterone acetate-salt, and deletion of BMAL1 in SMCs selectively upregulated TIMP4 (tissue inhibitor of metalloproteinase 4) and suppressed deoxycorticosterone acetate-salt-induced MMP (matrix metalloproteinase) activation and elastin breakages.	Salts	60-64	basic helix-loop-helix ARNT like 1	Mus musculus	7-12
29193800-6	2018	RESULTS: Pre-treatment with palmitate dampened Bmal1 mRNA and protein expression and glucagon-like peptide-1 secretion at 8 but not 20 hours after cell synchronization (P &lt; .05-.001).	Palmitates	28-37	basic helix-loop-helix ARNT like 1	Mus musculus	47-52
29193800-8	2018	Palmitate pre-treatment reduced expression of the Bmal1 downstream target, nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in the synthesis of NAD+ .	Palmitates	0-9	basic helix-loop-helix ARNT like 1	Mus musculus	50-55
29193800-8	2018	Palmitate pre-treatment reduced expression of the Bmal1 downstream target, nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in the synthesis of NAD+ .	NAD	160-164	basic helix-loop-helix ARNT like 1	Mus musculus	50-55
29191941-0	2018	Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice.	Glycogen	128-136	basic helix-loop-helix ARNT like 1	Mus musculus	61-66
29191941-14	2018	We observed differential responsiveness in diurnal rhythms of glycogen and glycogen metabolism genes and proteins in livers of hepatocyte-specific BMAL1 knockout and littermate control mice fed alcohol.	Glycogen	62-70	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
29191941-14	2018	We observed differential responsiveness in diurnal rhythms of glycogen and glycogen metabolism genes and proteins in livers of hepatocyte-specific BMAL1 knockout and littermate control mice fed alcohol.	Glycogen	75-83	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
29191941-14	2018	We observed differential responsiveness in diurnal rhythms of glycogen and glycogen metabolism genes and proteins in livers of hepatocyte-specific BMAL1 knockout and littermate control mice fed alcohol.	Alcohols	194-201	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
29276151-4	2018	Accordingly, SMH was observed in circadian-rhythm-disrupted or BMAL1-deficient mice.	N-(2-Ethoxyethyl)-N-{(2s)-2-Hydroxy-3-[(2r)-6-Hydroxy-4-Oxo-3,4-Dihydro-1'h-Spiro[chromene-2,3'-Piperidin]-1'-Yl]propyl}-2,6-Dimethylbenzenesulfonamide	13-16	basic helix-loop-helix ARNT like 1	Mus musculus	63-68
28730830-6	2017	More importantly, quantitative real-time polymerase chain reaction (qRT-PCR) analysis indicated that L-Carnitine supplementation would effectively counteract the negative alterations in gene expression which related to lipid metabolism (Srebp1, Acaca, Fasn, and Scd1), metabolic regulator (mTOR) and circadian rhythm (Bmal1, Per1, Cry1 and Dec1) in the liver of mice subjected to the chronic jet-lag.	Carnitine	101-112	basic helix-loop-helix ARNT like 1	Mus musculus	318-323
28687372-0	2017	Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice.	Sugars	39-44	basic helix-loop-helix ARNT like 1	Mus musculus	68-73
28816632-6	2017	Liver-specific ablation of Bmal1 expression alters metformin induction of AMPK and blood glucose response but does not completely abolish time of day differences.	Metformin	51-60	basic helix-loop-helix ARNT like 1	Mus musculus	27-32
28816632-6	2017	Liver-specific ablation of Bmal1 expression alters metformin induction of AMPK and blood glucose response but does not completely abolish time of day differences.	Glucose	89-96	basic helix-loop-helix ARNT like 1	Mus musculus	27-32
28333714-4	2017	Additionally, the transcription factors PHD1 and Bmal1 were identified to regulate LDL-C levels in mice by modulating cholesterol excretion.	Cholesterol	118-129	basic helix-loop-helix ARNT like 1	Mus musculus	49-54
28533986-12	2017	Atorvastatin increased the expression of clock core master genes Bmal1 and Npas2, decreased the expression of clock feedback genes Per2, Per3, and the clock targeted genes Dbp and Tef, whereas it had no effect on Cry1 and Nr1d1 expression.	Atorvastatin	0-12	basic helix-loop-helix ARNT like 1	Mus musculus	65-70
27925286-7	2017	Moreover, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ]-induced receptor activator of nuclear factor kappaB ligand (Rankl) expression was more strongly enhanced in both Bmal1-deficient bone and cultured osteoblasts, whereas overexpression of Bmal1/Clock conversely inhibited it in osteoblasts.	Calcitriol	10-39	basic helix-loop-helix ARNT like 1	Mus musculus	169-174
28470120-0	2017	Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma.	Temozolomide	56-68	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
28470120-5	2017	The maximum TMZ-induced DNA damage response, activation of apoptosis, and growth inhibition occurred near the daily peak in expression of the core clock gene Bmal1.	Temozolomide	12-15	basic helix-loop-helix ARNT like 1	Mus musculus	158-163
28470120-6	2017	Deletion of Bmal1 (Arntl) abolished circadian rhythms in gene expression and TMZ-induced activation of apoptosis and growth inhibition.	Temozolomide	77-80	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
28470120-6	2017	Deletion of Bmal1 (Arntl) abolished circadian rhythms in gene expression and TMZ-induced activation of apoptosis and growth inhibition.	Temozolomide	77-80	basic helix-loop-helix ARNT like 1	Mus musculus	19-24
28186121-0	2017	Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling.	gamma-Aminobutyric Acid	88-92	basic helix-loop-helix ARNT like 1	Mus musculus	22-27
28186121-5	2017	Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling.	gamma-Aminobutyric Acid	87-91	basic helix-loop-helix ARNT like 1	Mus musculus	37-42
27821487-0	2017	Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma.	Paclitaxel	64-74	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
27821487-3	2017	In this study, we investigated whether the circadian clock gene Bmal1 inhibited tumor development and increased paclitaxel sensitivity in tongue squamous cell carcinoma (TSCC).	Paclitaxel	112-122	basic helix-loop-helix ARNT like 1	Mus musculus	64-69
27821487-6	2017	After exposure to paclitaxel, Bmal1-overexpressing cells displayed a relative increase in apoptosis and were more susceptible to paclitaxel treatment in vivo Mechanistic investigations suggested a regulatory connection between Bmal1, TERT, and the oncogenic transcriptional repressor EZH2 (enhancer of zeste homolog 2), the recruitment of which to the TERT promoter increased paclitaxel-induced apoptosis and cell growth inhibition.	Paclitaxel	18-28	basic helix-loop-helix ARNT like 1	Mus musculus	30-35
27821487-6	2017	After exposure to paclitaxel, Bmal1-overexpressing cells displayed a relative increase in apoptosis and were more susceptible to paclitaxel treatment in vivo Mechanistic investigations suggested a regulatory connection between Bmal1, TERT, and the oncogenic transcriptional repressor EZH2 (enhancer of zeste homolog 2), the recruitment of which to the TERT promoter increased paclitaxel-induced apoptosis and cell growth inhibition.	Paclitaxel	18-28	basic helix-loop-helix ARNT like 1	Mus musculus	227-232
27821487-6	2017	After exposure to paclitaxel, Bmal1-overexpressing cells displayed a relative increase in apoptosis and were more susceptible to paclitaxel treatment in vivo Mechanistic investigations suggested a regulatory connection between Bmal1, TERT, and the oncogenic transcriptional repressor EZH2 (enhancer of zeste homolog 2), the recruitment of which to the TERT promoter increased paclitaxel-induced apoptosis and cell growth inhibition.	Paclitaxel	129-139	basic helix-loop-helix ARNT like 1	Mus musculus	30-35
27821487-6	2017	After exposure to paclitaxel, Bmal1-overexpressing cells displayed a relative increase in apoptosis and were more susceptible to paclitaxel treatment in vivo Mechanistic investigations suggested a regulatory connection between Bmal1, TERT, and the oncogenic transcriptional repressor EZH2 (enhancer of zeste homolog 2), the recruitment of which to the TERT promoter increased paclitaxel-induced apoptosis and cell growth inhibition.	Paclitaxel	129-139	basic helix-loop-helix ARNT like 1	Mus musculus	30-35
27821487-7	2017	Clinically, paclitaxel efficacy correlated positively with Bmal1 expression levels in TSCC.	Paclitaxel	12-22	basic helix-loop-helix ARNT like 1	Mus musculus	59-64
27821487-8	2017	Overall, our results identified Bmal1 as a novel tumor suppressor gene that elevates the sensitivity of cancer cells to paclitaxel, with potential implications as a chronotherapy timing biomarker in TSCC.	Paclitaxel	120-130	basic helix-loop-helix ARNT like 1	Mus musculus	32-37
29040059-6	2017	Thus, data suggested that Fen inhibits testosterone synthesis via pathways involving intracellular Ca2+ and clock genes (Bmal1, Rev-Erbalpha, Roralpha) as well as StAR mRNA expression in TM3 cells.	fenvalerate	26-29	basic helix-loop-helix ARNT like 1	Mus musculus	121-126
29040059-6	2017	Thus, data suggested that Fen inhibits testosterone synthesis via pathways involving intracellular Ca2+ and clock genes (Bmal1, Rev-Erbalpha, Roralpha) as well as StAR mRNA expression in TM3 cells.	Testosterone	39-51	basic helix-loop-helix ARNT like 1	Mus musculus	121-126
27113500-9	2016	The SCN-Bmal1-KD mice also showed greater weight gain, an abnormal circadian pattern of corticosterone, and an attenuated increase of corticosterone in response to stress.	Corticosterone	88-102	basic helix-loop-helix ARNT like 1	Mus musculus	8-13
27113500-9	2016	The SCN-Bmal1-KD mice also showed greater weight gain, an abnormal circadian pattern of corticosterone, and an attenuated increase of corticosterone in response to stress.	Corticosterone	134-148	basic helix-loop-helix ARNT like 1	Mus musculus	8-13
27468160-7	2016	Moreover, EGCG treatment altered diurnally oscillating expression pattern of key appetite-regulating genes, including AGRP, POMC, and CART, and key circadian genes Clock and Bmal1 in hypothalamus of DIO mice, indicating its central effect on feeding regulation.	epigallocatechin gallate	10-14	basic helix-loop-helix ARNT like 1	Mus musculus	174-179
27824722-1	2016	Bmal1-(brain and muscle ARNT-like protein-1) deficient (Bmal1) mice prematurely age because of an increased reactive oxygen species (ROS) production.	Reactive Oxygen Species	108-131	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
27824722-1	2016	Bmal1-(brain and muscle ARNT-like protein-1) deficient (Bmal1) mice prematurely age because of an increased reactive oxygen species (ROS) production.	Reactive Oxygen Species	133-136	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
27824722-8	2016	Thus, antioxidant treatment normalized cardiac function of Bmal1 mice, probably in part by scavenging ROS.	Reactive Oxygen Species	102-105	basic helix-loop-helix ARNT like 1	Mus musculus	59-64
27721414-7	2016	Thus, our data indicate that Bmal1 modulates lipoprotein production and biliary cholesterol excretion by regulating the expression of Mtp and Abcg5/Abcg8 via Shp and Gata4.	Cholesterol	80-91	basic helix-loop-helix ARNT like 1	Mus musculus	29-34
27506892-10	2016	PCR analysis and alizarin red S staining showed that insulin-mediated increases gene expression and calcium deposition were reduced in Bmal1 KO cells compared to wild-type cells.	Alizarin Red S	17-31	basic helix-loop-helix ARNT like 1	Mus musculus	135-140
27506892-10	2016	PCR analysis and alizarin red S staining showed that insulin-mediated increases gene expression and calcium deposition were reduced in Bmal1 KO cells compared to wild-type cells.	Calcium	100-107	basic helix-loop-helix ARNT like 1	Mus musculus	135-140
27140828-8	2016	The intracellular ROS levels in the ovary on proestrus day and in the oviduct on metestrus day increased significantly in Bmal1-/- mice compared with that of Bmal1+/+ mice.	Reactive Oxygen Species	18-21	basic helix-loop-helix ARNT like 1	Mus musculus	122-127
27140828-9	2016	Deletion of the core biological clock gene Bmal1 significantly decreases oocyte fertilization rate, early embryo development and implantation potential in female mice, and these may be possibly caused by excess ROS levels generated in ovary and oviduct.	Reactive Oxygen Species	211-214	basic helix-loop-helix ARNT like 1	Mus musculus	43-48
27427832-4	2016	Here, we show that nuclear receptor Small Heterodimer Partner (SHP), a regulator of bile acid metabolism, impacts the endogenous peripheral clock by directly regulating Bmal1.	Bile Acids and Salts	84-93	basic helix-loop-helix ARNT like 1	Mus musculus	169-174
27170536-6	2016	CR-dependent effects on some clock gene expression were impaired in the liver of mice deficient for BMAL1, suggesting importance of this transcriptional factor for the transcriptional reprogramming of the clock, however, BMAL1- independent mechanisms also exist.	Chromium	0-2	basic helix-loop-helix ARNT like 1	Mus musculus	100-105
27170536-6	2016	CR-dependent effects on some clock gene expression were impaired in the liver of mice deficient for BMAL1, suggesting importance of this transcriptional factor for the transcriptional reprogramming of the clock, however, BMAL1- independent mechanisms also exist.	Chromium	0-2	basic helix-loop-helix ARNT like 1	Mus musculus	221-226
26762333-5	2016	METHODS: We employed conditional deletion of the Bmal1 (also known as Arntl) gene (encoding a key circadian clock transcription factor) in beta cells using the tamoxifen-inducible CreER(T) recombination system.	Tamoxifen	160-169	basic helix-loop-helix ARNT like 1	Mus musculus	49-54
26762333-5	2016	METHODS: We employed conditional deletion of the Bmal1 (also known as Arntl) gene (encoding a key circadian clock transcription factor) in beta cells using the tamoxifen-inducible CreER(T) recombination system.	Tamoxifen	160-169	basic helix-loop-helix ARNT like 1	Mus musculus	70-75
26700733-6	2016	BMAL1 deficiency impaired CR-mediated changes in the plasma levels of IGF-1 and insulin.	Chromium	26-28	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
27486508-11	2016	CONCLUSIONS: These data support a fundamental role for Bmal1, the endogenous circadian clock, in glucose metabolism in the skeletal muscle.	Glucose	97-104	basic helix-loop-helix ARNT like 1	Mus musculus	55-60
26681113-4	2016	The origin of NF-kappaB activation was related to the age-dependent Bmal1/Clock/RORalpha/Rev-Erbalpha loop disruption, which lowers NAD(+) levels, reducing the SIRT1 deacetylase ability to inactivate NF-kappaB.	NAD	132-138	basic helix-loop-helix ARNT like 1	Mus musculus	68-88
26547624-5	2015	Liver-specific inactivation of Bmal1 led to elevated plasma LDL/VLDL cholesterol levels as a consequence of the disruption of the PCSK9/LDL receptor regulatory axis.	Cholesterol	69-80	basic helix-loop-helix ARNT like 1	Mus musculus	31-36
26456331-4	2015	Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements.	Polyamines	95-104	basic helix-loop-helix ARNT like 1	Mus musculus	146-151
26453621-6	2015	The administration of phenylephrine, a nonspecific alpha1-adrenergic receptor (AR) agonist, stimulated the expression of Tnfrsf11b, whereas the genetic ablation of alpha1B-AR signaling led to the alteration of Tnfrsf11b expression concomitant with Bmal1 and Per2 in bone.	Phenylephrine	22-35	basic helix-loop-helix ARNT like 1	Mus musculus	248-253
26142744-2	2015	Mice with targeted deletion of the clock geneBmal1 (Bmal1(-/-)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits.	Reactive Oxygen Species	93-116	basic helix-loop-helix ARNT like 1	Mus musculus	45-50
26000164-7	2015	We generated a tamoxifen-inducible skeletal muscle-specific Bmal1 knockout mouse model and performed a time-course microarray experiment to identify gene expression changes downstream of the molecular clock.	Tamoxifen	15-24	basic helix-loop-helix ARNT like 1	Mus musculus	60-65
25515595-3	2015	Under short photoperiods (8-h light/16-h dark), daily melatonin treatments 2 h before light offset have significantly altered the 24-h patterns of mRNA expression of circadian clock genes (per1, per2, bmal1 and clock) within the suprachiasmatic nuclei (SCN) mostly by increasing amplitude in their expressional rhythms without inducing robust phase shifts in them.	Melatonin	54-63	basic helix-loop-helix ARNT like 1	Mus musculus	201-206
25727018-7	2015	Interestingly, Clock mRNA and protein levels did not fluctuate with melatonin, BMP-4 or forskolin treatment, although Bmal1 expression was significantly increased by forskolin treatment.	Colforsin	166-175	basic helix-loop-helix ARNT like 1	Mus musculus	118-123
25640840-7	2015	Meanwhile, resveratrol modified the rhythmic expression of clock genes (Clock, Bmal1 and Per2) and clock-controlled lipid metabolism related genes (Sirt1, Pparalpha, Srebp-1c, Acc1 and Fas).	Resveratrol	11-22	basic helix-loop-helix ARNT like 1	Mus musculus	79-84
25543138-6	2015	Furthermore, we demonstrate that single-cell metabolic heterogeneity within the basal cell layer correlates with the circadian clock and that diurnal fluctuations in NADH/NAD+ ratio are Bmal1 dependent.	NAD	166-170	basic helix-loop-helix ARNT like 1	Mus musculus	186-191
25543138-6	2015	Furthermore, we demonstrate that single-cell metabolic heterogeneity within the basal cell layer correlates with the circadian clock and that diurnal fluctuations in NADH/NAD+ ratio are Bmal1 dependent.	NAD	171-175	basic helix-loop-helix ARNT like 1	Mus musculus	186-191
26125130-5	2015	In this study, we show that the wild-type mice display a rhythmic accumulation of hepatic phosphatidylcholine with a peak at ZT 22-0 while clock-deficient Bmal1(-/-) mice show elevated phosphatidylcholine levels in the liver associated with an atherogenic lipoprotein profile.	Phosphatidylcholines	185-204	basic helix-loop-helix ARNT like 1	Mus musculus	155-160
26125130-12	2015	Collectively, these data establish that hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis and suggest that an intact circadian timing system is important for the temporal coordination of phospholipid metabolism.	Phosphatidylcholines	48-67	basic helix-loop-helix ARNT like 1	Mus musculus	114-119
25454592-7	2014	Selectively deleting the Bmal1 (also known as Arntl or Mop3) clock gene from histaminergic cells removes this variation, producing higher HDC expression and brain histamine levels during the day.	Histamine	77-86	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
25454592-7	2014	Selectively deleting the Bmal1 (also known as Arntl or Mop3) clock gene from histaminergic cells removes this variation, producing higher HDC expression and brain histamine levels during the day.	Histamine	77-86	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
25454592-10	2014	We propose that for mammals with polyphasic/nonwake consolidating sleep, the local BMAL1-dependent clock directs appropriately timed declines and increases in histamine biosynthesis to produce an appropriate balance of wake and sleep within the overall daily cycle of rest and activity specified by the SCN.	Histamine	159-168	basic helix-loop-helix ARNT like 1	Mus musculus	83-88
25394423-6	2014	In contrast, the ZnO NPs seemed to suppress the inflammatory (decreased neutrophils in Bmal1(-/-) mice) and oxidative response (increased total glutathione in Bmal1(-/-) mice), but were also procoagulant with a significant increase of FVIII.	Zinc Oxide	17-20	basic helix-loop-helix ARNT like 1	Mus musculus	87-92
25394423-6	2014	In contrast, the ZnO NPs seemed to suppress the inflammatory (decreased neutrophils in Bmal1(-/-) mice) and oxidative response (increased total glutathione in Bmal1(-/-) mice), but were also procoagulant with a significant increase of FVIII.	Zinc Oxide	17-20	basic helix-loop-helix ARNT like 1	Mus musculus	159-164
25389966-4	2014	Mice without cardiac Bmal1 function show a significant decrease in the expression of genes associated with the fatty acid oxidative pathway, the tricarboxylic acid cycle, and the mitochondrial respiratory chain in the heart and develop severe progressive heart failure with age.	Fatty Acids	111-121	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
25389966-4	2014	Mice without cardiac Bmal1 function show a significant decrease in the expression of genes associated with the fatty acid oxidative pathway, the tricarboxylic acid cycle, and the mitochondrial respiratory chain in the heart and develop severe progressive heart failure with age.	Tricarboxylic Acids	145-163	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
25144192-6	2014	25 muM of palmitate significantly increased the transcriptional expression of Bmal1, without altering the expression of inflammatory markers TLR4, IkappaBalpha, and IL-6, nor the orexigenic neuropeptide AgRP, suggesting that the observed disruption of the molecular clock is the result of a mechanism distinct from that of hypothalamic cellular inflammation.	Palmitates	10-19	basic helix-loop-helix ARNT like 1	Mus musculus	78-83
25144192-7	2014	Furthermore, treatment with the PUFA DHA resulted in alterations in the circadian expression profile of Bmal1, although differentially from the effects of palmitate.	Docosahexaenoic Acids	37-40	basic helix-loop-helix ARNT like 1	Mus musculus	104-109
25225411-3	2014	The resultant SF1-Bmal1(-/-) females display embryonic implantation failure, which is rescued by progesterone supplementation, or bilateral or unilateral transplantation of wild-type ovaries into SF1-Bmal1(-/-) dams.	Progesterone	97-109	basic helix-loop-helix ARNT like 1	Mus musculus	18-23
25225411-5	2014	Our ovarian transcriptome analysis reveals that deletion of ovarian Bmal1 disrupts expression of transcripts associated with the circadian machinery and also genes critical for regulation of progesterone production, such as steroidogenic acute regulatory factor (Star).	Progesterone	191-203	basic helix-loop-helix ARNT like 1	Mus musculus	68-73
25203735-6	2014	Removal of melatonin signaling significantly affected the pattern of expression in the retina whereas in the photoreceptor layer only the Bmal1 circadian pattern of expression was affected by melatonin signaling removal.	Melatonin	192-201	basic helix-loop-helix ARNT like 1	Mus musculus	138-143
24740693-9	2014	We found that Bmal1-KO mice have a significantly (p&lt;0.001) higher ETP (437 +- 7 nM.min; mean +- SD, n=7) when compared with WT mice (ETP=220 +- 45 nM.min; mean +- SD, n=5).	etp	69-72	basic helix-loop-helix ARNT like 1	Mus musculus	14-19
25034823-6	2014	Activation of Erk1,2 MAP kinase (MAPK) during training for contextual fear memory and diurnal oscillation of MAPK activity and cAMP in the hippocampus is also lost in Bmal1-/- mice, suggesting that the memory defects are due to reduction of the memory consolidation pathway in the hippocampus.	Cyclic AMP	127-131	basic helix-loop-helix ARNT like 1	Mus musculus	167-172
24652800-7	2014	Functional analyses showed that Bmal1(lox/lox)/Ren1(d)Cre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels.	Sodium	174-180	basic helix-loop-helix ARNT like 1	Mus musculus	32-37
24652800-7	2014	Functional analyses showed that Bmal1(lox/lox)/Ren1(d)Cre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels.	Aldosterone	240-251	basic helix-loop-helix ARNT like 1	Mus musculus	32-37
24941219-6	2014	There was no significant difference in cellular proliferation between any of the groups, yet survival of proliferating cells, 6 weeks after the bromodeoxyuridine injection, was significantly greater in the BMAL1-KO animals.	Bromodeoxyuridine	144-161	basic helix-loop-helix ARNT like 1	Mus musculus	206-211
24442997-8	2014	CONCLUSION: These findings offer new insights for coordination of the circadian clock and metabolism in hepatocytes by circadian regulation of hepatic insulin sensitivity via CLOCK/BMAL1-dependent SIRT1 expression and provide a potential application of resveratrol for combating circadian misalignment-induced metabolic disorders.	Resveratrol	253-264	basic helix-loop-helix ARNT like 1	Mus musculus	181-186
24385426-5	2014	In vitro and in vivo protein-DNA interaction results demonstrate that, like CRY1, GM129 functions as a repressor by binding to the CLOCK BMAL1 complex on DNA.	gm129	82-87	basic helix-loop-helix ARNT like 1	Mus musculus	137-142
24481314-4	2014	Increased mTOR signaling is associated with accelerated aging; in accordance with that, treatment with the mTORC1 inhibitor rapamycin increased lifespan of Bmal1-/- mice by 50%.	Sirolimus	124-133	basic helix-loop-helix ARNT like 1	Mus musculus	156-161
24189141-5	2014	Here we show that already under unstressed conditions Arntl-deficient mice suffer from hypocortisolism with impaired adrenal responsiveness to ACTH and down-regulated transcription of genes involved in cholesterol transport in adrenocortical cells.	Cholesterol	202-213	basic helix-loop-helix ARNT like 1	Mus musculus	54-59
24025728-5	2014	BMAL1 was acetylated and degraded in the lungs of mice exposed to CS and in patients with chronic obstructive pulmonary disease (COPD), compared with lungs of the nonsmoking controls, linking it mechanistically to CS-induced reduction of SIRT1.	Cesium	66-68	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
24025728-5	2014	BMAL1 was acetylated and degraded in the lungs of mice exposed to CS and in patients with chronic obstructive pulmonary disease (COPD), compared with lungs of the nonsmoking controls, linking it mechanistically to CS-induced reduction of SIRT1.	Cesium	214-216	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
24025728-6	2014	Targeted deletion of Bmal1 in lung epithelium augmented inflammation in response to CS, which was not attenuated by the selective SIRT1 activator SRT1720 (EC50=0.16 muM) in these mice.	Cesium	84-86	basic helix-loop-helix ARNT like 1	Mus musculus	21-26
24025728-7	2014	Thus, the circadian clock, specifically the enhancer BMAL1 in epithelium, plays a pivotal role, mediated by SIRT1-dependent BMAL1, in the regulation of CS-induced lung inflammatory and injurious responses.	Cesium	152-154	basic helix-loop-helix ARNT like 1	Mus musculus	53-58
24025728-7	2014	Thus, the circadian clock, specifically the enhancer BMAL1 in epithelium, plays a pivotal role, mediated by SIRT1-dependent BMAL1, in the regulation of CS-induced lung inflammatory and injurious responses.	Cesium	152-154	basic helix-loop-helix ARNT like 1	Mus musculus	124-129
24965164-0	2014	Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus.	Quetiapine Fumarate	10-20	basic helix-loop-helix ARNT like 1	Mus musculus	40-45
24154875-5	2013	The application of a maximum-a-posteriori Bayesian inference method identified a linear model based on Rev-erbalpha and Bmal1 circadian expressions that accurately predicted for optimal irinotecan timing.	Irinotecan	186-196	basic helix-loop-helix ARNT like 1	Mus musculus	120-125
24231102-10	2013	The core liver clock components Clock-Bmal1 are a target of oleanolic acid in two animal models independently of the diets provided, and this compound requires APOA1-HDL for its hepatic action.	Oleanolic Acid	60-74	basic helix-loop-helix ARNT like 1	Mus musculus	38-43
24567902-6	2014	The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.	Glucose	13-20	basic helix-loop-helix ARNT like 1	Mus musculus	59-64
23750248-0	2013	Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism.	Glucose	84-91	basic helix-loop-helix ARNT like 1	Mus musculus	15-20
23750248-7	2013	Despite normal glucose and insulin tolerance, Bmal1 null mice had increased production of glucose from pyruvate, implying increased liver gluconeogenesis.	Glucose	90-97	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
23750248-7	2013	Despite normal glucose and insulin tolerance, Bmal1 null mice had increased production of glucose from pyruvate, implying increased liver gluconeogenesis.	Pyruvic Acid	103-111	basic helix-loop-helix ARNT like 1	Mus musculus	46-51
23750248-10	2013	These results show for the first time that global loss of Bmal1, and the consequent arrhythmicity, results in compensatory changes in adipokines involved in the cellular control of glucose metabolism.	Glucose	181-188	basic helix-loop-helix ARNT like 1	Mus musculus	58-63
23547261-7	2013	The expression of the master antioxidant regulatory factor Nrf2 (nuclear factor erythroid 2-related factor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in beta-Bmal1(-/-) islets, which may contribute to the observed increase in ROS accumulation.	Reactive Oxygen Species	247-250	basic helix-loop-helix ARNT like 1	Mus musculus	179-184
23395176-0	2013	O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.	o-glcnac	0-8	basic helix-loop-helix ARNT like 1	Mus musculus	62-67
22912383-0	2012	Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.	Superoxides	10-20	basic helix-loop-helix ARNT like 1	Mus musculus	80-85
22912383-3	2012	OBJECTIVE: The goals of the present study were to determine whether deletion of a critical component of the circadian clock, Bmal1, can influence endothelial NO synthase coupling and reactive oxygen species levels in arteries from Bmal1-knockout (KO) mice.	Reactive Oxygen Species	183-206	basic helix-loop-helix ARNT like 1	Mus musculus	125-130
22912383-5	2012	Aortae from Bmal1-KO mice exhibited enhanced superoxide levels as determined by electron paramagnetic resonance spectroscopy and dihydroethidium fluorescence, an elevation that was abrogated by administration of nitro-l-arginine methyl ester.	Superoxides	45-55	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
22912383-5	2012	Aortae from Bmal1-KO mice exhibited enhanced superoxide levels as determined by electron paramagnetic resonance spectroscopy and dihydroethidium fluorescence, an elevation that was abrogated by administration of nitro-l-arginine methyl ester.	dihydroethidium	129-144	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
22912383-5	2012	Aortae from Bmal1-KO mice exhibited enhanced superoxide levels as determined by electron paramagnetic resonance spectroscopy and dihydroethidium fluorescence, an elevation that was abrogated by administration of nitro-l-arginine methyl ester.	nitro-l-arginine methyl ester	212-241	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
22912383-6	2012	High-performance liquid chromatography analysis revealed a reduction in tetrahydrobiopterin and an increase in dihydrobiopterin levels in the lung and aorta of Bmal1-KO mice, whereas supplementation with tetrahydrobiopterin improved endothelial function in the circadian clock KO mice.	7,8-dihydrobiopterin	111-127	basic helix-loop-helix ARNT like 1	Mus musculus	160-165
22912383-6	2012	High-performance liquid chromatography analysis revealed a reduction in tetrahydrobiopterin and an increase in dihydrobiopterin levels in the lung and aorta of Bmal1-KO mice, whereas supplementation with tetrahydrobiopterin improved endothelial function in the circadian clock KO mice.	sapropterin	204-223	basic helix-loop-helix ARNT like 1	Mus musculus	160-165
22891617-4	2012	In this study, we demonstrated for the first time that acetylation levels of histone H3 lysine 9 (H3K9) at the promoter regions of clock genes, such as Dbp, Per2, and Bmal1, in the adipose tissue of ob/ob mice were significantly reduced compared with those of its control C57BL/6J mice.	Lysine	88-94	basic helix-loop-helix ARNT like 1	Mus musculus	167-172
22171092-7	2012	The expression of clock genes, such as Bmal1 and Clock, in mouse liver was decreased strongly 1 and 4 h after a single injection of 2,2,2-tribromoethanol.	tribromoethanol	132-153	basic helix-loop-helix ARNT like 1	Mus musculus	39-54
22316301-8	2012	And detected that the expression level and the peak of circadian clock genes decreased gradually and H2S could maintain the expression and amplitude of circadian clock genes such as Clock, Per2, Bmal1 and Rev-erbalphawithin a certain period time.	Hydrogen Sulfide	101-104	basic helix-loop-helix ARNT like 1	Mus musculus	195-200
22236088-4	2012	Bmal1-LUC and PER2::LUC bioluminescence decreased to basal levels after CHX application.	Cycloheximide	72-75	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
22900038-7	2012	Both BMAL1 and CLOCK proteins physically interact with the ATP-dependent DEAD-box RNA helicase MVH (mouse VASA homolog), a hallmark component of the CB.	Adenosine Triphosphate	59-62	basic helix-loop-helix ARNT like 1	Mus musculus	5-10
22069332-7	2011	We also identify the clock component Bmal1 as an O-GlcNAc-modified protein.	o-glcnac	49-57	basic helix-loop-helix ARNT like 1	Mus musculus	37-42
22101268-4	2011	BMAL1 deficient fibroblasts had an increased sensitivity to hydrogen peroxide treatment, and reduced sensitivity to DNA damaging anticancer drugs etoposide and daunorubicin.	Hydrogen Peroxide	60-77	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
22101268-4	2011	BMAL1 deficient fibroblasts had an increased sensitivity to hydrogen peroxide treatment, and reduced sensitivity to DNA damaging anticancer drugs etoposide and daunorubicin.	Etoposide	146-155	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
22101268-4	2011	BMAL1 deficient fibroblasts had an increased sensitivity to hydrogen peroxide treatment, and reduced sensitivity to DNA damaging anticancer drugs etoposide and daunorubicin.	Daunorubicin	160-172	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	130-153	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	130-153	basic helix-loop-helix ARNT like 1	Mus musculus	175-180
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	155-158	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	155-158	basic helix-loop-helix ARNT like 1	Mus musculus	175-180
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	232-235	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
22101268-5	2011	Increased sensitivity of Bmal1(-/-) cells to oxidative stress was p53 independent and correlated with the disrupted regulation of reactive oxygen species (ROS) homeostasis in BMAL1 deficient cells: indeed, circadian oscillations of ROS level can be induced in wild-type but not in Bmal1(-/-) cells.	Reactive Oxygen Species	232-235	basic helix-loop-helix ARNT like 1	Mus musculus	175-180
22249125-0	2011	Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.	Selenium	0-8	basic helix-loop-helix ARNT like 1	Mus musculus	151-156
22249125-4	2011	By screening a library of small molecules in a cell-based reporter system, we identified L-methyl-selenocysteine as a positive regulator of the core clock protein, BMAL1.	selenomethylselenocysteine	89-112	basic helix-loop-helix ARNT like 1	Mus musculus	164-169
22249125-5	2011	L-methyl-selenocysteine up-regulates BMAL1 at the transcriptional level both in cultured cells and in mice.	selenomethylselenocysteine	0-23	basic helix-loop-helix ARNT like 1	Mus musculus	37-42
22249125-8	2011	These findings define selenium as circadian modulator and indicate that the tissue protective effect of selenium results, at least in part, from up-regulation of BMAL1 expression and subsequent enhancement of CLOCK/BMAL1-mediated transcription.	Selenium	22-30	basic helix-loop-helix ARNT like 1	Mus musculus	162-167
22249125-8	2011	These findings define selenium as circadian modulator and indicate that the tissue protective effect of selenium results, at least in part, from up-regulation of BMAL1 expression and subsequent enhancement of CLOCK/BMAL1-mediated transcription.	Selenium	22-30	basic helix-loop-helix ARNT like 1	Mus musculus	215-220
22249125-8	2011	These findings define selenium as circadian modulator and indicate that the tissue protective effect of selenium results, at least in part, from up-regulation of BMAL1 expression and subsequent enhancement of CLOCK/BMAL1-mediated transcription.	Selenium	104-112	basic helix-loop-helix ARNT like 1	Mus musculus	162-167
22249125-8	2011	These findings define selenium as circadian modulator and indicate that the tissue protective effect of selenium results, at least in part, from up-regulation of BMAL1 expression and subsequent enhancement of CLOCK/BMAL1-mediated transcription.	Selenium	104-112	basic helix-loop-helix ARNT like 1	Mus musculus	215-220
21250933-4	2011	METHODS: We examined how haloperidol treatment, either acute (both at day and night) or chronically over 14 days, alters the expression of three clock gene protein products (PER1, PER2, BMAL1) across the mouse brain by means of immunohistochemistry.	Haloperidol	25-36	basic helix-loop-helix ARNT like 1	Mus musculus	186-191
22045262-8	2011	In contrast to previous studies, in these Bmal1-/- mice on a C57Bl/6 background, the loss of stimulated insulin secretion, interestingly, is with glucose but not to other depolarizing secretagogues, suggesting that events downstream of membrane depolarization are largely normal in Bmal1-/- islets.	Glucose	146-153	basic helix-loop-helix ARNT like 1	Mus musculus	42-47
22045262-10	2011	Inhibition of Ucp2, in isolated islets, leads to a rescue of the glucose-induced ATP production and insulin secretion in Bmal1-/- islets.	Glucose	65-72	basic helix-loop-helix ARNT like 1	Mus musculus	121-126
21521686-4	2011	The longer mBMAL1 fragment (BMAL490) includes Lys-537, which is rhythmically acetylated by mCLOCK in vivo.	Lysine	46-49	basic helix-loop-helix ARNT like 1	Mus musculus	11-17
21521686-9	2011	We propose that Lys-537(mBMAL1) acetylation enhances mCRY1 binding by affecting electrostatic interactions predominantly with the mCRY1 tail.	Lysine	16-19	basic helix-loop-helix ARNT like 1	Mus musculus	24-30
21721861-11	2011	However, the average expression of Rev-erbalpha, Per2, and Bmal1 were down-regulated 2- to 10-fold with irinotecan at the worst ZT, while being minimally or unaffected at the best ZT, irrespective of sex.	Irinotecan	104-114	basic helix-loop-helix ARNT like 1	Mus musculus	59-64
21182907-7	2011	Quantitative real-time PCR and immunoblot analysis demonstrated that TCDD exposure alters expression of the canonical clock genes, Bmal1 and Per2 in the ovary.	Polychlorinated Dibenzodioxins	69-73	basic helix-loop-helix ARNT like 1	Mus musculus	131-136
21182907-10	2011	Furthermore, co-immunoprecipitation demonstrated time-of-day dependent interactions of AhR with BMAL1 that were enhanced after TCDD treatment.	Polychlorinated Dibenzodioxins	127-131	basic helix-loop-helix ARNT like 1	Mus musculus	96-101
21364973-4	2011	Annotation of BMAL1 targets confirms carbohydrate and lipid metabolism as the major output of the circadian clock in mouse liver.	Carbohydrates	37-49	basic helix-loop-helix ARNT like 1	Mus musculus	14-19
21966465-11	2011	Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol.	Fatty Acids	131-142	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
21966465-11	2011	Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol.	Triglycerides	154-167	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
21966465-11	2011	Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol.	Fatty Acids, Nonesterified	169-185	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
21966465-11	2011	Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol.	Cholesterol	191-202	basic helix-loop-helix ARNT like 1	Mus musculus	16-21
21966465-12	2011	Elevation of the circulating fatty acids level induced the formation of ectopic fat in the liver and skeletal muscle in Bmal1 -/- mice.	Fatty Acids	29-40	basic helix-loop-helix ARNT like 1	Mus musculus	120-125
21887357-0	2011	Ketamine influences CLOCK:BMAL1 function leading to altered circadian gene expression.	Ketamine	0-8	basic helix-loop-helix ARNT like 1	Mus musculus	26-31
21887357-3	2011	Ketamine modulates CLOCK:BMAL1-mediated transcriptional activation when these regulators are ectopically expressed in NG108-15 neuronal cells.	Ketamine	0-8	basic helix-loop-helix ARNT like 1	Mus musculus	25-30
21887357-5	2011	We analyzed the effect of ketamine on circadian gene expression and observed a dose-dependent reduction in the amplitude of circadian transcription of the Bmal1, Per2, and Cry1 genes.	Ketamine	26-34	basic helix-loop-helix ARNT like 1	Mus musculus	155-160
21887357-6	2011	Finally, chromatin-immunoprecipitation analyses revealed that ketamine altered the recruitment of the CLOCK:BMAL1 complex on circadian promoters in a time-dependent manner.	Ketamine	62-70	basic helix-loop-helix ARNT like 1	Mus musculus	108-113
20576619-4	2010	Suppressing Bmal1 expression in murine colon cancer cells (C26) and fibroblast cells (L929) decreased apoptosis induced by Etoposid, reduced the distribution of cells in the G2/M phases treated by Docetaxel and decreased DNA damage induced by Cisplatin.	Etoposide	123-131	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
20576619-4	2010	Suppressing Bmal1 expression in murine colon cancer cells (C26) and fibroblast cells (L929) decreased apoptosis induced by Etoposid, reduced the distribution of cells in the G2/M phases treated by Docetaxel and decreased DNA damage induced by Cisplatin.	Docetaxel	197-206	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
20576619-4	2010	Suppressing Bmal1 expression in murine colon cancer cells (C26) and fibroblast cells (L929) decreased apoptosis induced by Etoposid, reduced the distribution of cells in the G2/M phases treated by Docetaxel and decreased DNA damage induced by Cisplatin.	Cisplatin	243-252	basic helix-loop-helix ARNT like 1	Mus musculus	12-17
20534529-2	2010	The heme receptor Rev-erb alpha, a core negative component of the circadian network, controls circadian oscillation of several clock genes, including Bmal1 Rev-erb alpha protein degradation can be triggered by inhibitors of glycogen synthase kinase 3beta, such as lithium, and also by serum shock, which synchronizes circadian rhythms in cultured cells.	Lithium	264-271	basic helix-loop-helix ARNT like 1	Mus musculus	150-155
20157581-0	2009	Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1.	Acetylcysteine	12-31	basic helix-loop-helix ARNT like 1	Mus musculus	128-133
20157581-1	2009	Deficiency of the circadian clock protein BMAL1 leads to premature aging and increased levels of reactivate oxygen species in several tissues of mice.	Oxygen	108-114	basic helix-loop-helix ARNT like 1	Mus musculus	42-47
19439589-11	2009	The Ca(2+)(i) response of SCN cells to the RyR agonist caffeine was reduced in BMAL1(-/-) compared with BMAL1(+/+) mice.	Caffeine	55-63	basic helix-loop-helix ARNT like 1	Mus musculus	79-84
19439589-11	2009	The Ca(2+)(i) response of SCN cells to the RyR agonist caffeine was reduced in BMAL1(-/-) compared with BMAL1(+/+) mice.	Caffeine	55-63	basic helix-loop-helix ARNT like 1	Mus musculus	104-109
19286518-4	2009	CLOCK:BMAL1 regulates the circadian expression of NAMPT (nicotinamide phosphoribosyltransferase), an enzyme that provides a rate-limiting step in the NAD+ salvage pathway.	NAD	150-154	basic helix-loop-helix ARNT like 1	Mus musculus	6-11
19323828-4	2009	These results, taken together with controversial DMH lesion results published by the same laboratory, appear to establish the DMH as the site of a Bmal1-dependent circadian mechanism necessary and sufficient for food anticipatory rhythms.	Dimenhydrinate	49-52	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
19323828-4	2009	These results, taken together with controversial DMH lesion results published by the same laboratory, appear to establish the DMH as the site of a Bmal1-dependent circadian mechanism necessary and sufficient for food anticipatory rhythms.	Dimenhydrinate	126-129	basic helix-loop-helix ARNT like 1	Mus musculus	147-152
19273720-6	2009	Akt and subsequent nitric oxide signaling, a pathway critical to vascular function, was significantly attenuated in arteries from Bmal1-knockout mice.	Nitric Oxide	19-31	basic helix-loop-helix ARNT like 1	Mus musculus	130-135
18798788-6	2009	We found that melatonin at the receptor affinity range (i.e., nm) affects the expression of the clock genes mPer1, mClock, mBmal1 and mNPAS2 (neuronal PAS domain protein 2) differentially in a pertussis toxin-sensitive manner: a decrease in Per1 and Clock, an increase in NPAS2 and no change in Bmal1 expression.	Melatonin	14-23	basic helix-loop-helix ARNT like 1	Mus musculus	123-129
19041764-5	2008	Rosiglitazone treatment induced aortic expression of Bmal1 mRNA, and ChIP and promoter assays revealed that Bmal1 is a direct PPARgamma target gene.	Rosiglitazone	0-13	basic helix-loop-helix ARNT like 1	Mus musculus	53-58
19041764-5	2008	Rosiglitazone treatment induced aortic expression of Bmal1 mRNA, and ChIP and promoter assays revealed that Bmal1 is a direct PPARgamma target gene.	Rosiglitazone	0-13	basic helix-loop-helix ARNT like 1	Mus musculus	108-113
18768761-6	2008	Furthermore, norepinephrine and forskolin were able to synchronize circadian rhythms in bmal1.	Norepinephrine	13-27	basic helix-loop-helix ARNT like 1	Mus musculus	88-93
18768761-6	2008	Furthermore, norepinephrine and forskolin were able to synchronize circadian rhythms in bmal1.	Colforsin	32-41	basic helix-loop-helix ARNT like 1	Mus musculus	88-93
18779586-3	2008	The liver plays a well known role in glucose homeostasis, and we report here that mice with a liver-specific deletion of Bmal1, an essential clock component, exhibited hypoglycemia restricted to the fasting phase of the daily feeding cycle, exaggerated glucose clearance, and loss of rhythmic expression of hepatic glucose regulatory genes.	Glucose	37-44	basic helix-loop-helix ARNT like 1	Mus musculus	121-126
18662547-4	2008	We show that the HDAC activity of the NAD(+)-dependent SIRT1 enzyme is regulated in a circadian manner, correlating with rhythmic acetylation of BMAL1 and H3 Lys9/Lys14 at circadian promoters.	NAD	38-44	basic helix-loop-helix ARNT like 1	Mus musculus	145-150
18487412-9	2008	However, mice exposed to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1 microg/kg of body weight) displayed decreased phase shifts in response to light and had altered expression of Per1 and Bmal1.	Polychlorinated Dibenzodioxins	41-76	basic helix-loop-helix ARNT like 1	Mus musculus	205-210
18487412-9	2008	However, mice exposed to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1 microg/kg of body weight) displayed decreased phase shifts in response to light and had altered expression of Per1 and Bmal1.	Polychlorinated Dibenzodioxins	78-82	basic helix-loop-helix ARNT like 1	Mus musculus	205-210
18258755-0	2008	The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.	Testosterone	72-84	basic helix-loop-helix ARNT like 1	Mus musculus	28-33
18258755-5	2008	Male Bmal1 KO mice had low testosterone and high luteinizing hormone serum concentrations, suggesting a defect in testicular Leydig cells.	Testosterone	27-39	basic helix-loop-helix ARNT like 1	Mus musculus	5-10
18258755-6	2008	Importantly, Leydig cells rhythmically express BMAL1 protein, suggesting peripheral control of testosterone production by this clock protein.	Testosterone	95-107	basic helix-loop-helix ARNT like 1	Mus musculus	47-52
19704445-2	2008	Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription.	Catecholamines	88-102	basic helix-loop-helix ARNT like 1	Mus musculus	307-312
19704445-2	2008	Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription.	Catecholamines	88-102	basic helix-loop-helix ARNT like 1	Mus musculus	322-327
19704445-2	2008	Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription.	Dopamine	113-121	basic helix-loop-helix ARNT like 1	Mus musculus	307-312
19704445-2	2008	Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription.	Dopamine	113-121	basic helix-loop-helix ARNT like 1	Mus musculus	322-327
18075593-4	2007	Here we show that CLOCK also acetylates a non-histone substrate: its own partner, BMAL1, is specifically acetylated on a unique, highly conserved Lys 537 residue.	Lysine	146-149	basic helix-loop-helix ARNT like 1	Mus musculus	82-87
17298173-4	2007	To discriminate between these mechanisms, we engineered a mouse strain with a conditionally active liver clock, in which REV-ERBalpha represses the transcription of the essential core clock gene Bmal1 in a doxycycline-dependent manner.	Doxycycline	206-217	basic helix-loop-helix ARNT like 1	Mus musculus	195-200
18419267-9	2007	BMAL1 is specifically acetylated on a unique, highly conserved Lys-537 residue.	Lysine	63-66	basic helix-loop-helix ARNT like 1	Mus musculus	0-5
17069763-0	2006	Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro.	Tretinoin	65-78	basic helix-loop-helix ARNT like 1	Mus musculus	20-25
16847346-3	2006	The early aging phenotype correlates with increased levels of reactive oxygen species in some tissues of the Bmal1(-/- )animals.	Reactive Oxygen Species	62-85	basic helix-loop-helix ARNT like 1	Mus musculus	109-114
16414186-6	2006	Northern blots showed that circadian expression of the clock genes mPer1, mPer2, Clock, and BMAL1, and of the clock-controlled output gene D-site binding protein (DBP), was maintained in Vitamin A-deficient mice.	Vitamin A	187-196	basic helix-loop-helix ARNT like 1	Mus musculus	92-97
16109848-3	2005	Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine residue (Lys259) in vivo.	Lysine	130-136	basic helix-loop-helix ARNT like 1	Mus musculus	19-24
15917646-8	2005	Comparison of the in vivo responses of these mutants to the chemotherapeutic drug, cyclophosphamide (CY), has established a direct correlation between drug toxicity and the functional status of the CLOCK/BMAL1 transcriptional complex.	Cyclophosphamide	83-99	basic helix-loop-helix ARNT like 1	Mus musculus	204-209
15917646-8	2005	Comparison of the in vivo responses of these mutants to the chemotherapeutic drug, cyclophosphamide (CY), has established a direct correlation between drug toxicity and the functional status of the CLOCK/BMAL1 transcriptional complex.	Cyclophosphamide	101-103	basic helix-loop-helix ARNT like 1	Mus musculus	204-209
15689397-0	2005	Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.	Cyclophosphamide	52-68	basic helix-loop-helix ARNT like 1	Mus musculus	115-120
15994025-3	2005	In this study in mice, we investigated the delayed effects of single and repeated (i.e. 14 days) administration of the antidepressant fluoxetine and the psychostimulant cocaine on the brain expression of clock genes Period1, Period2, Period3, Clock, Bmal1, Cryptochrome1, Cryptochrome2, and NPAS2 (neuronal PAS domain protein 2), and their putative target gene, serotonin N-acetyltransferase.	Cocaine	169-176	basic helix-loop-helix ARNT like 1	Mus musculus	250-255
15193144-4	2004	It was hypothesized that DEC-mediated repression on the mPer1 promoter is achieved by binding to E-box elements and interacting with Bmal1.	dec	25-28	basic helix-loop-helix ARNT like 1	Mus musculus	133-138
15298678-7	2004	An effect of the Ser phosphorylation was investigated by mutating Ser247 of mCRY1 and Ser265 of mCRY2 to Asp, which resulted in attenuation of each mCRYs" ability to inhibit BMAL1: CLOCK-mediated transcription, whereas a similar mutation at Ser557 of mCRY2 induced no measurable change in its activity.	Serine	17-20	basic helix-loop-helix ARNT like 1	Mus musculus	174-179
15298678-7	2004	An effect of the Ser phosphorylation was investigated by mutating Ser247 of mCRY1 and Ser265 of mCRY2 to Asp, which resulted in attenuation of each mCRYs" ability to inhibit BMAL1: CLOCK-mediated transcription, whereas a similar mutation at Ser557 of mCRY2 induced no measurable change in its activity.	Aspartic Acid	105-108	basic helix-loop-helix ARNT like 1	Mus musculus	174-179