PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33951176-0	2021	FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction.	Glucose	24-31	fibroblast growth factor 21	Mus musculus	0-5
33513515-7	2021	Upregulated ins2 transcription and FGF21 protein in male mice prenatally exposed to 600 mug/kg Phe suggested that these animals appeared compensatory enhancement in beta-cell function.	phenanthrene	95-98	fibroblast growth factor 21	Mus musculus	35-40
34046014-2	2021	Fibroblast growth factor 21 (FGF21) is a circulating protein primarily secreted by the liver that lowers blood glucose levels, corrects abnormal lipid profiles, and mitigates non-alcoholic fatty liver disease.	Glucose	111-118	fibroblast growth factor 21	Mus musculus	0-27
34046014-2	2021	Fibroblast growth factor 21 (FGF21) is a circulating protein primarily secreted by the liver that lowers blood glucose levels, corrects abnormal lipid profiles, and mitigates non-alcoholic fatty liver disease.	Glucose	111-118	fibroblast growth factor 21	Mus musculus	29-34
33951176-2	2021	The biological activity of FGF21 was first shown to induce insulin independent glucose uptake in adipocytes through the GLUT1 transporter.	Glucose	79-86	fibroblast growth factor 21	Mus musculus	27-32
33951176-7	2021	FGF21-PEG normalized plasma glucose in streptozotocin-treated mice, a model of type 1 diabetes (T1D), without restoring pancreatic beta-cell function.	Glucose	28-35	fibroblast growth factor 21	Mus musculus	0-5
33951176-7	2021	FGF21-PEG normalized plasma glucose in streptozotocin-treated mice, a model of type 1 diabetes (T1D), without restoring pancreatic beta-cell function.	Streptozocin	39-53	fibroblast growth factor 21	Mus musculus	0-5
33951176-8	2021	FGF21-PEG also normalized plasma glucose levels and improved glucose tolerance in mice chronically treated with an insulin competitive insulin receptor antagonist, a model of autoimmune/Type-B insulin resistance.	Glucose	33-40	fibroblast growth factor 21	Mus musculus	0-5
33951176-8	2021	FGF21-PEG also normalized plasma glucose levels and improved glucose tolerance in mice chronically treated with an insulin competitive insulin receptor antagonist, a model of autoimmune/Type-B insulin resistance.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	0-5
32037512-8	2021	Mechanically, P7C3-A20 stimulated fibroblast growth factor 21 (FGF21) and FGF1 via activating liver kinase B1 (LKB1) and AMP-activated protein kinase (AMPK), which further resulted in a reduced nuclear translocation of CREB regulated transcription coactivator 2 (CRTC2).	Adenosine Monophosphate	121-124	fibroblast growth factor 21	Mus musculus	34-61
33944779-5	2021	Unexpectedly, OPA1 deficiency induced fibroblast growth factor 21 (FGF21) as a BATokine in an activating transcription factor 4 (ATF4)-dependent manner.	batokine	79-87	fibroblast growth factor 21	Mus musculus	38-65
33944779-5	2021	Unexpectedly, OPA1 deficiency induced fibroblast growth factor 21 (FGF21) as a BATokine in an activating transcription factor 4 (ATF4)-dependent manner.	batokine	79-87	fibroblast growth factor 21	Mus musculus	67-72
32037512-8	2021	Mechanically, P7C3-A20 stimulated fibroblast growth factor 21 (FGF21) and FGF1 via activating liver kinase B1 (LKB1) and AMP-activated protein kinase (AMPK), which further resulted in a reduced nuclear translocation of CREB regulated transcription coactivator 2 (CRTC2).	Adenosine Monophosphate	121-124	fibroblast growth factor 21	Mus musculus	63-68
32037512-12	2021	CONCLUSIONS AND IMPLICATIONS: The NAD+ boosting agent P7C3-A20 alleviates NAFLD through stimulating FGF21 and FGF1 in an LKB1/AMPK/CRTC2-dependent manner and shaping gut microbiota.	NAD	34-37	fibroblast growth factor 21	Mus musculus	100-105
33849585-0	2021	Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy.	Triglycerides	19-31	fibroblast growth factor 21	Mus musculus	87-92
33615874-1	2021	Fibroblast growth factor-21 (FGF21) is a hormonal regulator of metabolism; it promotes glucose oxidation and the thermogenic capacity of adipose tissues.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	0-27
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	21-26
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	71-76
33850218-9	2021	Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice.	Iron	128-132	fibroblast growth factor 21	Mus musculus	71-76
33615874-1	2021	Fibroblast growth factor-21 (FGF21) is a hormonal regulator of metabolism; it promotes glucose oxidation and the thermogenic capacity of adipose tissues.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	29-34
33131727-0	2021	Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 production.	perfluorononanoic acid	36-58	fibroblast growth factor 21	Mus musculus	146-151
33780737-0	2021	Effective and safe delivery of GLP-1AR and FGF-21 plasmids using amino-functionalized dual-mesoporous silica nanoparticles in vitro and in vivo.	dual-mesoporous	86-101	fibroblast growth factor 21	Mus musculus	43-49
33780737-0	2021	Effective and safe delivery of GLP-1AR and FGF-21 plasmids using amino-functionalized dual-mesoporous silica nanoparticles in vitro and in vivo.	Silicon Dioxide	102-108	fibroblast growth factor 21	Mus musculus	43-49
33780737-8	2021	Moreover, N-EDMSNs can simultaneously carry FGF-21 plasmids and liraglutide and successfully transfect them into Hepa1-6 cells.	n-edmsns	10-18	fibroblast growth factor 21	Mus musculus	44-50
33780737-10	2021	In mice experiments, N-EDMSNs/pFGF21 treatment resulted in higher FGF-21 expression in the liver than pFGF21 treatment with hydrodynamic delivery.	n-edmsns	21-29	fibroblast growth factor 21	Mus musculus	66-72
33131727-3	2021	Herein, we show that when PFNA (3 mg kg-1 body weight) was orally administered during gestational days 1-18, dams showed an increase in liver weight and hepatic FGF21 synthesis via PPARalpha activation, and their female offspring (PFNA mice) showed an increase in liver weight and hepatic FGF21 synthesis from postnatal day (PND) 1 to PND21, which were corrected by the administration of the PPARalpha antagonist GW6471 from PND1-14 (pup-GW).	perfluorononanoic acid	26-30	fibroblast growth factor 21	Mus musculus	289-294
33131727-7	2021	The findings indicate that prenatal exposure to PFNA through increased FGF21 production in postnatal female offspring impedes postnatal activation of SCN-VAP neurons, which suppresses pubertal onset in AVPV-kisspeptin neurons and reproductive endocrine axis, leading to delayed puberty and dysfunction of ovaries.	perfluorononanoic acid	48-52	fibroblast growth factor 21	Mus musculus	71-76
33131727-3	2021	Herein, we show that when PFNA (3 mg kg-1 body weight) was orally administered during gestational days 1-18, dams showed an increase in liver weight and hepatic FGF21 synthesis via PPARalpha activation, and their female offspring (PFNA mice) showed an increase in liver weight and hepatic FGF21 synthesis from postnatal day (PND) 1 to PND21, which were corrected by the administration of the PPARalpha antagonist GW6471 from PND1-14 (pup-GW).	perfluorononanoic acid	26-30	fibroblast growth factor 21	Mus musculus	161-166
33693480-12	2022	Mechanistically, FGF21 reduces hypercholesterolemia by accelerating triglyceride-rich lipoprotein turnover as a result of enhancing adipose tissue thermogenesis, thereby alleviating atherosclerotic lesion formation and severity.	Triglycerides	68-80	fibroblast growth factor 21	Mus musculus	17-22
33783357-6	2021	Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin.	Sodium Selenite	59-74	fibroblast growth factor 21	Mus musculus	202-208
33577983-0	2021	FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	33-38
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	fibroblast growth factor 21	Mus musculus	374-379
33599110-0	2021	FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner.	NAD	117-121	fibroblast growth factor 21	Mus musculus	0-5
33599110-3	2021	Fibroblast growth factor 21 (FGF21) has received substantial attention as a potential therapeutic agent for diabetes via regulating glucose and lipid metabolism.	Glucose	132-139	fibroblast growth factor 21	Mus musculus	0-27
33599110-3	2021	Fibroblast growth factor 21 (FGF21) has received substantial attention as a potential therapeutic agent for diabetes via regulating glucose and lipid metabolism.	Glucose	132-139	fibroblast growth factor 21	Mus musculus	29-34
33599110-6	2021	The in vitro results revealed that FGF21 directly prevented EPC damage induced by high glucose, and the mechanistic studies demonstrated that nicotinamide adenine dinucleotide (NAD+ ) was dramatically decreased in EPCs challenged with high glucose, whereas FGF21 treatment significantly increased NAD+ content in an AMPK-dependent manner, resulting in improved angiogenic capability of EPCs.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	35-40
33599110-6	2021	The in vitro results revealed that FGF21 directly prevented EPC damage induced by high glucose, and the mechanistic studies demonstrated that nicotinamide adenine dinucleotide (NAD+ ) was dramatically decreased in EPCs challenged with high glucose, whereas FGF21 treatment significantly increased NAD+ content in an AMPK-dependent manner, resulting in improved angiogenic capability of EPCs.	NAD	142-175	fibroblast growth factor 21	Mus musculus	257-262
33599110-6	2021	The in vitro results revealed that FGF21 directly prevented EPC damage induced by high glucose, and the mechanistic studies demonstrated that nicotinamide adenine dinucleotide (NAD+ ) was dramatically decreased in EPCs challenged with high glucose, whereas FGF21 treatment significantly increased NAD+ content in an AMPK-dependent manner, resulting in improved angiogenic capability of EPCs.	NAD	177-181	fibroblast growth factor 21	Mus musculus	35-40
33599110-6	2021	The in vitro results revealed that FGF21 directly prevented EPC damage induced by high glucose, and the mechanistic studies demonstrated that nicotinamide adenine dinucleotide (NAD+ ) was dramatically decreased in EPCs challenged with high glucose, whereas FGF21 treatment significantly increased NAD+ content in an AMPK-dependent manner, resulting in improved angiogenic capability of EPCs.	NAD	177-181	fibroblast growth factor 21	Mus musculus	257-262
33599110-6	2021	The in vitro results revealed that FGF21 directly prevented EPC damage induced by high glucose, and the mechanistic studies demonstrated that nicotinamide adenine dinucleotide (NAD+ ) was dramatically decreased in EPCs challenged with high glucose, whereas FGF21 treatment significantly increased NAD+ content in an AMPK-dependent manner, resulting in improved angiogenic capability of EPCs.	Glucose	240-247	fibroblast growth factor 21	Mus musculus	35-40
33599110-7	2021	These results indicate that FGF21 promotes ischaemic angiogenesis and the angiogenic ability of EPCs under diabetic conditions by activating the AMPK/NAD+ pathway.	NAD	150-154	fibroblast growth factor 21	Mus musculus	28-33
33785868-8	2021	This may be attributed, in part, to the induction of FGF21 and regulation of lipid metabolism, which are considered to be involved in increased fatty acid oxidation and reduced lipogenesis in the liver.	Fatty Acids	144-154	fibroblast growth factor 21	Mus musculus	53-58
33577983-6	2021	Furthermore, chronic compound 10 treatment combined with FGF21 led to synergistic glucose lowering in lean, streptozotocin-induced diabetic mice.	Glucose	82-89	fibroblast growth factor 21	Mus musculus	57-62
33577983-6	2021	Furthermore, chronic compound 10 treatment combined with FGF21 led to synergistic glucose lowering in lean, streptozotocin-induced diabetic mice.	Streptozocin	108-122	fibroblast growth factor 21	Mus musculus	57-62
33681679-8	2021	These effects were demonstrated to be mediated by the reduced function of the peroxisome proliferator-activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) axis, which can be reversed by treatment with docosahexaenoic acid, PPARalpha agonist, or FGF21.	Docosahexaenoic Acids	221-241	fibroblast growth factor 21	Mus musculus	139-166
33677937-6	2021	RESULTS: Liraglutide, FGF21, and their low-dose combination significantly reduced atheromatous plaque in aorta, decreased weight, glucose, and leptin levels, and increased adiponectin levels.	Glucose	130-137	fibroblast growth factor 21	Mus musculus	22-27
33277119-2	2021	Though FGF21 is crucial to glucose, lipid, and energy homeostasis, it is not straightforward to develop a new drug with FGF21 due to its short half-life in serum.	Glucose	27-34	fibroblast growth factor 21	Mus musculus	7-12
33277119-5	2021	The efficacy study of LAPS-FGF21 in a Diet-Induced Obesity (DIO) mouse model revealed that LAPS-FGF21 reduced body weight effectively accompanied by improved glucose tolerance in a dose-dependent manner.	Glucose	158-165	fibroblast growth factor 21	Mus musculus	96-101
33277119-6	2021	The administration of LAPS-FGF21 also improved the blood profiles with a significant reduction in cholesterol and triglyceride levels.	Cholesterol	98-109	fibroblast growth factor 21	Mus musculus	27-32
33277119-6	2021	The administration of LAPS-FGF21 also improved the blood profiles with a significant reduction in cholesterol and triglyceride levels.	Triglycerides	114-126	fibroblast growth factor 21	Mus musculus	27-32
33246135-2	2021	CREB3L3 controls hepatic triglyceride and glucose metabolism by activating plasma fibroblast growth factor 21 (FGF21) and lipoprotein lipase.	Triglycerides	25-37	fibroblast growth factor 21	Mus musculus	82-109
33421947-7	2021	FINDINGS: Two Fc-FGF21 variants showed enhanced beta-Klotho binding affinity in vitro as well as improved glucose lowering effect in vivo.	Glucose	106-113	fibroblast growth factor 21	Mus musculus	17-22
33421947-8	2021	One of the dual agonists, GLP-1-Fc-FGF21 D1, provided potent and sustained glucose lowering effect in diabetic mice models.	Glucose	75-82	fibroblast growth factor 21	Mus musculus	35-40
33125701-6	2021	FGF21 circulating levels and FGF21 expression in the myocardium were also increased in wild-type mice after chronic alcohol intake.	Alcohols	116-123	fibroblast growth factor 21	Mus musculus	0-5
33125701-6	2021	FGF21 circulating levels and FGF21 expression in the myocardium were also increased in wild-type mice after chronic alcohol intake.	Alcohols	116-123	fibroblast growth factor 21	Mus musculus	29-34
33125701-7	2021	Fgf21-/- mice develop a higher degree of cardiac hypertrophy, fibrosis, and cardiac dysfunction after chronic alcohol consumption than wild-type mice.	Alcohols	110-117	fibroblast growth factor 21	Mus musculus	0-5
33125701-8	2021	Moreover, the myocardium of Fgf21-/- mice showed signs of metabolic deregulation, oxidative stress, and mitochondrial dysfunction after alcohol intake.	Alcohols	136-143	fibroblast growth factor 21	Mus musculus	28-33
33295692-1	2021	Fibroblast growth factor 21 (FGF21) is a regulator of glucose and lipid metabolism.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	0-27
33295692-1	2021	Fibroblast growth factor 21 (FGF21) is a regulator of glucose and lipid metabolism.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	29-34
33229553-0	2020	Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.	Triclosan	0-9	fibroblast growth factor 21	Mus musculus	60-65
33364514-0	2020	Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice.	Serotonin	28-37	fibroblast growth factor 21	Mus musculus	108-113
33330965-3	2021	Increased levels of FGF21 decrease harmful alcohol intake in mice.	Alcohols	43-50	fibroblast growth factor 21	Mus musculus	20-25
33364514-5	2020	Treatment with SB20471 reversed the decreases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in db/db mice, whereas it suppressed the increases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in KKAy mice.	2-Chloro-5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidine	15-22	fibroblast growth factor 21	Mus musculus	56-61
33364514-5	2020	Treatment with SB20471 reversed the decreases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in db/db mice, whereas it suppressed the increases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in KKAy mice.	2-Chloro-5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidine	15-22	fibroblast growth factor 21	Mus musculus	81-86
33364514-5	2020	Treatment with SB20471 reversed the decreases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in db/db mice, whereas it suppressed the increases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in KKAy mice.	2-Chloro-5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidine	15-22	fibroblast growth factor 21	Mus musculus	81-86
33364514-5	2020	Treatment with SB20471 reversed the decreases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in db/db mice, whereas it suppressed the increases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in KKAy mice.	2-Chloro-5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidine	15-22	fibroblast growth factor 21	Mus musculus	81-86
33364514-6	2020	Moreover, treatment with SB204741 increased plasma FGF21 levels and expression of hepatic FGF21, htr2a, and Sdf2l1 in C57BL6J mice, whereas it decreased plasma FGF21 levels and hepatic FGF21 expression in KK mice.	N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	25-33	fibroblast growth factor 21	Mus musculus	51-56
33364514-6	2020	Moreover, treatment with SB204741 increased plasma FGF21 levels and expression of hepatic FGF21, htr2a, and Sdf2l1 in C57BL6J mice, whereas it decreased plasma FGF21 levels and hepatic FGF21 expression in KK mice.	N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	25-33	fibroblast growth factor 21	Mus musculus	90-95
33364514-6	2020	Moreover, treatment with SB204741 increased plasma FGF21 levels and expression of hepatic FGF21, htr2a, and Sdf2l1 in C57BL6J mice, whereas it decreased plasma FGF21 levels and hepatic FGF21 expression in KK mice.	N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	25-33	fibroblast growth factor 21	Mus musculus	90-95
33364514-6	2020	Moreover, treatment with SB204741 increased plasma FGF21 levels and expression of hepatic FGF21, htr2a, and Sdf2l1 in C57BL6J mice, whereas it decreased plasma FGF21 levels and hepatic FGF21 expression in KK mice.	N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea	25-33	fibroblast growth factor 21	Mus musculus	90-95
33229553-4	2020	The presumably protective HFD-induced hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21) was blunted by TCS.	Triclosan	135-138	fibroblast growth factor 21	Mus musculus	84-111
33229553-4	2020	The presumably protective HFD-induced hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21) was blunted by TCS.	Triclosan	135-138	fibroblast growth factor 21	Mus musculus	113-118
33229553-5	2020	TCS-altered Fgf21 expression aligned with aberrant expression of genes encoding metabolic enzymes manifested as profound systemic metabolic changes that disturb homeostasis of amino acids, fatty acids, and glucose.	Triclosan	0-3	fibroblast growth factor 21	Mus musculus	12-17
33229553-5	2020	TCS-altered Fgf21 expression aligned with aberrant expression of genes encoding metabolic enzymes manifested as profound systemic metabolic changes that disturb homeostasis of amino acids, fatty acids, and glucose.	Fatty Acids	189-200	fibroblast growth factor 21	Mus musculus	12-17
33229553-5	2020	TCS-altered Fgf21 expression aligned with aberrant expression of genes encoding metabolic enzymes manifested as profound systemic metabolic changes that disturb homeostasis of amino acids, fatty acids, and glucose.	Glucose	206-213	fibroblast growth factor 21	Mus musculus	12-17
33229553-8	2020	Using reverse-genetic approaches, we demonstrate that, along with HFD, TCS induces hepatic steatosis and steatohepatitis jointly regulated by the transcription factor ATF4 and the nuclear receptor PPARalpha, which participate in the transcriptional regulation of the Fgf21 gene.	Triclosan	71-74	fibroblast growth factor 21	Mus musculus	267-272
32959519-0	2020	Dietary Methionine Restriction Signals to the Brain Through Fibroblast Growth Factor 21 to Regulate Energy Balance and Remodeling of Adipose Tissue.	Methionine	8-18	fibroblast growth factor 21	Mus musculus	60-87
33204884-6	2020	Interestingly, pemafibrate increased the serum fibroblast growth factor 21 concentration and decreased serum insulin concentrations in HFD mice.	(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid	15-26	fibroblast growth factor 21	Mus musculus	47-74
33268375-6	2020	In preadipocytes, enoxacin led to a reduction of miR-34a-5p expression and up-regulation of its target genes (e.g., Fgfr1, Klb, and Sirt1), thus increasing FGF21 signaling and promoting beige adipogenesis.	Enoxacin	18-26	fibroblast growth factor 21	Mus musculus	156-161
32959519-1	2020	OBJECTIVE: Restricting dietary methionine to 0.17% in mice increases energy expenditure (EE), reduces fat deposition, and improves metabolic health by increasing hepatic fibroblast growth factor 21 (FGF21).	Methionine	31-41	fibroblast growth factor 21	Mus musculus	170-197
32959519-1	2020	OBJECTIVE: Restricting dietary methionine to 0.17% in mice increases energy expenditure (EE), reduces fat deposition, and improves metabolic health by increasing hepatic fibroblast growth factor 21 (FGF21).	Methionine	31-41	fibroblast growth factor 21	Mus musculus	199-204
32957703-7	2020	FGF21 significantly decreased body weight and glucose concentrations, and increased circulating adiponectin levels.	Glucose	46-53	fibroblast growth factor 21	Mus musculus	0-5
32957703-8	2020	FGF21 treatment alleviated insulin resistance and decreased circulating concentrations of triglycerides, which were significantly correlated with plaque size.	Triglycerides	90-103	fibroblast growth factor 21	Mus musculus	0-5
32957703-10	2020	The monocyte chemoattractant protein-1 levels were decreased and beta-hydroxybutyrate levels were increased by FGF21 treatment.	3-Hydroxybutyric Acid	65-85	fibroblast growth factor 21	Mus musculus	111-116
32736697-6	2020	By using inhibitors against various signaling pathways, p38, Akt, NF-kappaB, and PKA appeared potentially involved in GLN-mediated FGF21 production in AML12 cells; GLN was able to mediate activation of NF-kappaB, p38 or PKA/CREB signaling.	Glucosamine	118-121	fibroblast growth factor 21	Mus musculus	131-136
32767856-4	2020	TC-E treatment upregulates the expression of Ucp1 and Fgf21 significantly and activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and human.	Trichloroethylene	0-4	fibroblast growth factor 21	Mus musculus	54-59
32768941-7	2020	H&E staining results showed that the karyopyknosis and tissue edema around dentate gyrus and Cornu Amonis 3 (CA3) area of hippocampus were also inhibited by FGF21 in aging and diabetes mice.	Helium	0-3	fibroblast growth factor 21	Mus musculus	157-162
32736697-0	2020	Glucosamine regulation of fibroblast growth factor 21 expression in liver and adipose tissues.	Glucosamine	0-11	fibroblast growth factor 21	Mus musculus	26-53
32736697-7	2020	Our accumulated findings suggest that GLN may potentially improve the metabolic performance by inducing FGF21 production in liver and adipose tissues and such induction in liver cells may act in part due to GLN induction of the NF-kappaB, p38 and PKA pathways.	Glucosamine	38-41	fibroblast growth factor 21	Mus musculus	104-109
32736697-4	2020	This study aimed to reveal whether and how GLN would modulate FGF21 production in relation to metabolism.	Glucosamine	43-46	fibroblast growth factor 21	Mus musculus	62-67
32445748-7	2020	Possibly, FGF21 improves mitochondrial function, inhibits mitochondrial division, and reduces ROS production by maintaining mitochondrial dynamics and function to reduce NLRP3 related pyroptosis and inhibits VECs endoplasmic reticulum stress, thereby exerting an anti-atherosclerotic effect.	ros	94-97	fibroblast growth factor 21	Mus musculus	10-15
32450094-7	2020	The in vivo hypoglycemic activity of HSA-mFGF21 using streptozotocin (STZ)-induced type I diabetes model mice, in which insulin secretion was suppressed, showed that a single intravenous administration of HSA-mFGF21 rapidly alleviated hyperglycemia.	Streptozocin	54-68	fibroblast growth factor 21	Mus musculus	41-47
32922298-4	2020	Adipose tissue lipolysis causes an increase in the amount of circulating free fatty acids, which leads to the activation of peroxisome proliferators-activated receptor alpha and an increased expression of FGF21 in hepatocytes.	Fatty Acids	78-89	fibroblast growth factor 21	Mus musculus	205-210
32922298-5	2020	We further show that hypoxia-induced elevation of reactive oxygen species, but not the hypoxia-inducible factor, is responsible for the lipolysis and FGF21 expression.	Oxygen	59-65	fibroblast growth factor 21	Mus musculus	150-155
32450094-7	2020	The in vivo hypoglycemic activity of HSA-mFGF21 using streptozotocin (STZ)-induced type I diabetes model mice, in which insulin secretion was suppressed, showed that a single intravenous administration of HSA-mFGF21 rapidly alleviated hyperglycemia.	Streptozocin	70-73	fibroblast growth factor 21	Mus musculus	41-47
32450094-9	2020	A twice weekly administration of HSA-mFGF21 continuously suppressed blood glucose levels and ameliorated the abnormalities of adipose tissue induced by STZ treatment.	Streptozocin	152-155	fibroblast growth factor 21	Mus musculus	37-43
32522588-13	2020	DEHP-treated mice exhibited actively expressed browning marker genes (i.e., Pparg, Adrb1, Adrb3, Ppargc1a, and Ucp1) in WAT, increased blood FGF21 levels, and higher amounts of BAT, supporting the browning-like effects in vivo.	Diethylhexyl Phthalate	0-4	fibroblast growth factor 21	Mus musculus	141-146
32431116-1	2020	BACKGROUND: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model.	Streptozocin	122-136	fibroblast growth factor 21	Mus musculus	12-39
32431116-1	2020	BACKGROUND: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model.	Streptozocin	122-136	fibroblast growth factor 21	Mus musculus	41-46
32431116-10	2020	However, all the renal abnormalities above in OVE26 mice were significantly attenuated by 3-month FGF21 treatment associated with improvement of renal adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) activity and sirtuin 1 (SIRT1) expression.	Adenosine	151-160	fibroblast growth factor 21	Mus musculus	98-103
32431116-10	2020	However, all the renal abnormalities above in OVE26 mice were significantly attenuated by 3-month FGF21 treatment associated with improvement of renal adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) activity and sirtuin 1 (SIRT1) expression.	Adenosine Monophosphate	179-182	fibroblast growth factor 21	Mus musculus	98-103
32688339-7	2020	Liver glycogen was decreased by FGF21 and increased by chow.	Glycogen	6-14	fibroblast growth factor 21	Mus musculus	32-37
32688339-8	2020	The hepatic gene expression profiles suggest that FGF21 increased uptake of fatty acids and lipoproteins, channeled TGs towards production of cholesterol and bile acid, reduced lipogenesis and increased hepatic glucose output.	Fatty Acids	76-87	fibroblast growth factor 21	Mus musculus	50-55
32688339-8	2020	The hepatic gene expression profiles suggest that FGF21 increased uptake of fatty acids and lipoproteins, channeled TGs towards production of cholesterol and bile acid, reduced lipogenesis and increased hepatic glucose output.	Cholesterol	142-153	fibroblast growth factor 21	Mus musculus	50-55
32688339-8	2020	The hepatic gene expression profiles suggest that FGF21 increased uptake of fatty acids and lipoproteins, channeled TGs towards production of cholesterol and bile acid, reduced lipogenesis and increased hepatic glucose output.	Bile Acids and Salts	158-167	fibroblast growth factor 21	Mus musculus	50-55
32755998-1	2020	Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism.	Glucose	174-181	fibroblast growth factor 21	Mus musculus	0-27
32755998-1	2020	Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism.	Glucose	174-181	fibroblast growth factor 21	Mus musculus	29-34
32755998-0	2020	Fibroblast growth factor-21 potentiates glucose transport in skeletal muscle fibers.	Glucose	40-47	fibroblast growth factor 21	Mus musculus	0-27
32755998-2	2020	Although FGF21 has been associated with glucose metabolism in skeletal muscle cells, its cellular mechanism in adult skeletal muscle fibers glucose uptake is poorly understood.	Glucose	40-47	fibroblast growth factor 21	Mus musculus	9-14
32755998-3	2020	In the present study, we found that FGF21 induced a dose-response effect, increasing glucose uptake in skeletal muscle fibers from flexor digitorum brevis muscle of mice, evaluated using the fluorescent glucose analog 2-NBDG (300 microM) in single living fibers.	Glucose	85-92	fibroblast growth factor 21	Mus musculus	36-41
32755998-3	2020	In the present study, we found that FGF21 induced a dose-response effect, increasing glucose uptake in skeletal muscle fibers from flexor digitorum brevis muscle of mice, evaluated using the fluorescent glucose analog 2-NBDG (300 microM) in single living fibers.	Glucose	203-210	fibroblast growth factor 21	Mus musculus	36-41
32755998-3	2020	In the present study, we found that FGF21 induced a dose-response effect, increasing glucose uptake in skeletal muscle fibers from flexor digitorum brevis muscle of mice, evaluated using the fluorescent glucose analog 2-NBDG (300 microM) in single living fibers.	2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose	218-224	fibroblast growth factor 21	Mus musculus	36-41
32470979-0	2020	Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet-Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21.	cyanidin-3-o-glucoside	8-28	fibroblast growth factor 21	Mus musculus	158-163
32755998-5	2020	The use of PI3K inhibitors such as Wortmannin (100 nM) and LY294002 (50 microM) completely prevented the FGF21-dependent glucose uptake.	Wortmannin	35-45	fibroblast growth factor 21	Mus musculus	105-110
32470979-17	2020	However, Cy3G increased hepatic Fgf21 expression in mice in Exp.	cy3	9-12	fibroblast growth factor 21	Mus musculus	32-37
32470979-20	2020	CONCLUSIONS: Dietary Cy3G may reduce body weight and exert metabolic homeostatic effects in mice via changes in hepatic FGF21.	cy3	21-24	fibroblast growth factor 21	Mus musculus	120-125
32755998-5	2020	The use of PI3K inhibitors such as Wortmannin (100 nM) and LY294002 (50 microM) completely prevented the FGF21-dependent glucose uptake.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	fibroblast growth factor 21	Mus musculus	105-110
32755998-5	2020	The use of PI3K inhibitors such as Wortmannin (100 nM) and LY294002 (50 microM) completely prevented the FGF21-dependent glucose uptake.	Glucose	121-128	fibroblast growth factor 21	Mus musculus	105-110
32755998-8	2020	FGF21 at low concentrations potentiated the effect of insulin on glucose uptake but at high concentrations, completely inhibited the uptake in the presence of insulin.	Glucose	65-72	fibroblast growth factor 21	Mus musculus	0-5
32755998-9	2020	These results suggest that FGF21 regulates glucose uptake by a mechanism mediated by GLUT4 and dependent on atypical PKC-zeta- in skeletal muscle.	Glucose	43-50	fibroblast growth factor 21	Mus musculus	27-32
32227589-0	2020	FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation.	Cholesterol	33-44	fibroblast growth factor 21	Mus musculus	0-5
32584895-9	2020	Pemafibrate treatment also increased plasma levels of the PPARalpha-regulated gene, fibroblast growth factor (FGF) 21 in WT mice.	(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid	0-11	fibroblast growth factor 21	Mus musculus	84-117
32584895-11	2020	Treatment of cultured endothelial cells with FGF21 protein led to increases in endothelial cell network formation and migration, which were canceled by pretreatment with L-NAME.	NG-Nitroarginine Methyl Ester	170-176	fibroblast growth factor 21	Mus musculus	45-50
32821334-14	2020	CONCLUSION: Our study suggests that the liver steatosis-ameliorating effects of ipragliflozin in ob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly through the PGC-1alpha/PPARalpha-FGF21 pathway.	ipragliflozin	80-93	fibroblast growth factor 21	Mus musculus	201-206
32724479-0	2020	Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21.	Lactic Acid	35-42	fibroblast growth factor 21	Mus musculus	99-126
32724479-7	2020	We detected defects in the astrocyte-neuron lactate shuttle system in the in vivo and in vitro models of AD and identified FGF21 as a neuroprotective molecule that can rescue these deficits.	Lactic Acid	44-51	fibroblast growth factor 21	Mus musculus	123-128
32724479-11	2020	Modulation of the astrocyte-neuron lactate shuttle system can be one of the most efficient strategies for FGF21 in Alzheimer-like degeneration and contributes to improvements in brain metabolic defects and amyloid beta-induced cytotoxicity.	Lactic Acid	35-42	fibroblast growth factor 21	Mus musculus	106-111
32610475-4	2020	Based on the gene ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs, the critical role of closely interlocked glucose metabolism was determined in HFD-induced cardiac remodeling DEGs, including Nr4a1, Fgf21, Slc2a3, Pck1, Gck, Hmgcs2, and Bpgm.	Glucose	177-184	fibroblast growth factor 21	Mus musculus	268-273
32227589-4	2020	We sought to assess whether FGF21 could inhibit AS by regulating cholesterol metabolism in foam cells via autophagy and to elucidate the underlying molecular mechanisms.	Cholesterol	65-76	fibroblast growth factor 21	Mus musculus	28-33
32227589-11	2020	Our results indicated that FGF21-induced autophagy promoted cholesterol efflux to reduce cholesterol accumulation in foam cells by up-regulating RACK1 expression.	Cholesterol	60-71	fibroblast growth factor 21	Mus musculus	27-32
32227589-11	2020	Our results indicated that FGF21-induced autophagy promoted cholesterol efflux to reduce cholesterol accumulation in foam cells by up-regulating RACK1 expression.	Cholesterol	89-100	fibroblast growth factor 21	Mus musculus	27-32
32227589-13	2020	Taken together, our results indicated that FGF21 induces autophagy to promote cholesterol efflux and reduce cholesterol accumulation in foam cells through RACK1-mediated AMPK activation and ATG5 interaction.	Cholesterol	78-89	fibroblast growth factor 21	Mus musculus	43-48
32227589-13	2020	Taken together, our results indicated that FGF21 induces autophagy to promote cholesterol efflux and reduce cholesterol accumulation in foam cells through RACK1-mediated AMPK activation and ATG5 interaction.	Cholesterol	108-119	fibroblast growth factor 21	Mus musculus	43-48
32233059-1	2020	Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity, alleviates the process of acute pancreatitis (AP).	Glucose	85-92	fibroblast growth factor 21	Mus musculus	0-27
32233059-1	2020	Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity, alleviates the process of acute pancreatitis (AP).	Glucose	85-92	fibroblast growth factor 21	Mus musculus	29-34
32307816-0	2020	Exposure of female mice to perfluorooctanoic acid suppresses hypothalamic kisspeptin-reproductive endocrine system through enhanced hepatic fibroblast growth factor 21 synthesis, leading to ovulation failure and prolonged dioestrus.	perfluorooctanoic acid	27-49	fibroblast growth factor 21	Mus musculus	140-167
32307816-4	2020	The present study investigated whether exposure to PFOA via PPARalpha activation alters the synthesis of hepatic fibroblast growth factor 21 (FGF21) to disturb female neuroendocrine and reproductive function.	perfluorooctanoic acid	51-55	fibroblast growth factor 21	Mus musculus	113-140
32307816-7	2020	PFOA via activation of PPARalpha increased dose-dependently hepatic FGF21 expression, leading to elevated serum and hypothalamic FGF21 concentrations.	perfluorooctanoic acid	0-4	fibroblast growth factor 21	Mus musculus	68-73
32307816-7	2020	PFOA via activation of PPARalpha increased dose-dependently hepatic FGF21 expression, leading to elevated serum and hypothalamic FGF21 concentrations.	perfluorooctanoic acid	0-4	fibroblast growth factor 21	Mus musculus	129-134
32307816-8	2020	Treatment of PFOA mice with the PPARalpha antagonist GW6471 or the FGF21 inhibitor PD173074 rescued SCN vasopressin and AVPV-kisspeptin expression.	PD 173074	83-91	fibroblast growth factor 21	Mus musculus	67-72
32307816-10	2020	The present study provides in vivo evidence that exposure to PFOA (>=2 mg kg-1 ) in mice causes down-regulation of the kisspeptin-reproductive endocrine system by enhancing PPARalpha-mediated hepatic FGF21 expression.	perfluorooctanoic acid	61-65	fibroblast growth factor 21	Mus musculus	200-205
32276645-2	2020	Metformin is used for the treatment of type 2 diabetes and was reported to exert therapeutic effects against rheumatoid arthritis and obesity by improving mitochondrial dysfunction via the activation of fibroblast growth factor 21.	Metformin	0-9	fibroblast growth factor 21	Mus musculus	203-230
32210821-7	2020	Administration of recombinant FGF21 to cisplatin-induced AKI mice resulted in significantly decreased blood urea nitrogen (BUN) and serum creatinine levels, as well as significantly reduced protein levels of kidney injury molecule-1 (TIM-1), C-caspase 3, and Bax.	Cisplatin	39-48	fibroblast growth factor 21	Mus musculus	30-35
32151974-5	2020	Knockdown of Kiss1 in HFHS-fed CREBH-Tg Fgf21-/- mice showed partially canceled improvement of glucose metabolism.	Glucose	95-102	fibroblast growth factor 21	Mus musculus	40-45
32151974-3	2020	Deficiency of FGF21 in CREBH-Tg mice mostly canceled the improvement of obesity, but the suppression of inflammation of epidermal WAT, amelioration of insulin resistance, and improvement of glucose metabolism still sustained.	Glucose	190-197	fibroblast growth factor 21	Mus musculus	14-19
32210821-7	2020	Administration of recombinant FGF21 to cisplatin-induced AKI mice resulted in significantly decreased blood urea nitrogen (BUN) and serum creatinine levels, as well as significantly reduced protein levels of kidney injury molecule-1 (TIM-1), C-caspase 3, and Bax.	Urea	108-112	fibroblast growth factor 21	Mus musculus	30-35
32210821-7	2020	Administration of recombinant FGF21 to cisplatin-induced AKI mice resulted in significantly decreased blood urea nitrogen (BUN) and serum creatinine levels, as well as significantly reduced protein levels of kidney injury molecule-1 (TIM-1), C-caspase 3, and Bax.	Nitrogen	113-121	fibroblast growth factor 21	Mus musculus	30-35
32210821-7	2020	Administration of recombinant FGF21 to cisplatin-induced AKI mice resulted in significantly decreased blood urea nitrogen (BUN) and serum creatinine levels, as well as significantly reduced protein levels of kidney injury molecule-1 (TIM-1), C-caspase 3, and Bax.	Creatinine	138-148	fibroblast growth factor 21	Mus musculus	30-35
32210821-8	2020	H&E-stained kidney sections from cisplatin-induced AKI mice treated with recombinant FGF21 showed a relatively normal renal tissue structure, a reduced number of necrotic sites and vacuolar changes, and decreased casts, suggesting alleviated renal tubular injury.	Helium	0-3	fibroblast growth factor 21	Mus musculus	85-90
32210821-8	2020	H&E-stained kidney sections from cisplatin-induced AKI mice treated with recombinant FGF21 showed a relatively normal renal tissue structure, a reduced number of necrotic sites and vacuolar changes, and decreased casts, suggesting alleviated renal tubular injury.	Cisplatin	33-42	fibroblast growth factor 21	Mus musculus	85-90
32210821-9	2020	Experiments with an AKI cell model (cisplatin-treated HK-2 cells) yielded similar results as the mouse model; recombinant FGF21 significantly downregulated protein expression levels of TIM-1, C-caspase 3, and Bax.	Cisplatin	36-45	fibroblast growth factor 21	Mus musculus	122-127
32210821-10	2020	Furthermore, administration of recombinant FGF21 to cisplatin-treated AKI models significantly increased SIRT1 expression, and the beneficial effects of FGF21 on kidney injury were reversed by SIRT1 knockdown.	Cisplatin	52-61	fibroblast growth factor 21	Mus musculus	43-48
32210821-11	2020	Collectively, our results suggest that SIRT1 mediates the protective effect of FGF21 on cisplatin-induced kidney injury.	Cisplatin	88-97	fibroblast growth factor 21	Mus musculus	79-84
32047920-4	2020	Circulating FGF21 levels are robustly increased by diets that are high in carbohydrate but low in protein, and exogenous FGF21 treatment reduces the consumption of sweet foods and alcohol while alternatively increasing the consumption of protein.	Carbohydrates	74-86	fibroblast growth factor 21	Mus musculus	12-17
32355754-0	2020	Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance.	Alcohols	0-7	fibroblast growth factor 21	Mus musculus	86-91
32355754-3	2020	Recently, FGF21, best known for its role in lipid and glucose homeostasis regulation, and its obligate co-receptor beta-klotho have been shown to inhibit ethanol ingestion and metabolism.	Ethanol	154-161	fibroblast growth factor 21	Mus musculus	10-15
32355754-9	2020	Results: Long-term ethanol treatment induced FGF21 resistance in mouse pancreatic islets.	Ethanol	19-26	fibroblast growth factor 21	Mus musculus	45-50
32355754-11	2020	In vitro and ex vivo experiments showed that short-term ethanol treatment upregulated the expression of FGF21 signaling pathway-related genes and proteins, without affecting beta-cell survival or function.	Ethanol	56-63	fibroblast growth factor 21	Mus musculus	104-109
32355754-12	2020	Conclusions: Long-term ethanol consumption induces FGF21 resistance-mediated pancreatic beta-cell dysfunction, and thus diabetes pathogenesis risk.	Ethanol	23-30	fibroblast growth factor 21	Mus musculus	51-56
32047920-4	2020	Circulating FGF21 levels are robustly increased by diets that are high in carbohydrate but low in protein, and exogenous FGF21 treatment reduces the consumption of sweet foods and alcohol while alternatively increasing the consumption of protein.	Alcohols	180-187	fibroblast growth factor 21	Mus musculus	121-126
32058595-10	2020	Conclusively, tanshinol A exerted hypolipidemic effect and hepatoprotective effect through restoring triton-1339W-suppressed mRNA expression, which may be involved in Atf4/Fgf21/Vldlr and Ptgs2/Il-10 signaling pathways.	tanshinol	14-25	fibroblast growth factor 21	Mus musculus	172-177
32058595-10	2020	Conclusively, tanshinol A exerted hypolipidemic effect and hepatoprotective effect through restoring triton-1339W-suppressed mRNA expression, which may be involved in Atf4/Fgf21/Vldlr and Ptgs2/Il-10 signaling pathways.	tyloxapol	101-113	fibroblast growth factor 21	Mus musculus	172-177
32070295-0	2020	Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis.	Uric Acid	0-9	fibroblast growth factor 21	Mus musculus	82-87
31997152-5	2020	Furthermore, we treated MPTP-induced Parkinson"s disease (PD) model mice with the recombinant FGF21 via intranasal pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	24-28	fibroblast growth factor 21	Mus musculus	94-99
31997152-6	2020	The results showed that FGF21 treatment significantly improves behavioral performances and prevents tyrosine hydroxylase (TH) loss in the substantia nigra par compacta (SNpc) and striatum.	Tyrosine	100-108	fibroblast growth factor 21	Mus musculus	24-29
31997152-8	2020	Moreover, FGF21 attenuates microglia and astrocyte activation induced by MPTP, leading to a low level of inflammation in the brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	73-77	fibroblast growth factor 21	Mus musculus	10-15
31997152-9	2020	Our data indicate that FGF21 prevents dopaminergic neuron loss and shows beneficial effects against MPTP-induced PD syndrome in mice, indicating it might be a potent candidate for developing novel drugs to deal with PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	100-104	fibroblast growth factor 21	Mus musculus	23-28
32184729-3	2020	Fibroblast growth factor 21 (FGF21), a member of the fibroblast growth factors (FGFs) family, regulates a variety of pharmacological activities, including energy metabolism, glucose and lipid metabolism, and insulin sensitivity.	Glucose	174-181	fibroblast growth factor 21	Mus musculus	0-27
32184729-3	2020	Fibroblast growth factor 21 (FGF21), a member of the fibroblast growth factors (FGFs) family, regulates a variety of pharmacological activities, including energy metabolism, glucose and lipid metabolism, and insulin sensitivity.	Glucose	174-181	fibroblast growth factor 21	Mus musculus	29-34
32087969-8	2020	Mechanistically, A2AR agonist CGS21680 increased iBAT-derived fibroblast growth factor 21 (FGF21).	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	30-38	fibroblast growth factor 21	Mus musculus	62-89
32087969-8	2020	Mechanistically, A2AR agonist CGS21680 increased iBAT-derived fibroblast growth factor 21 (FGF21).	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	30-38	fibroblast growth factor 21	Mus musculus	91-96
32070295-10	2020	Silencing FGF21 abolished the ameliorative effects of miR-149-5p inhibitor on uric acid-induced hepatocytes lipid accumulation, while overexpression of FGF21 prevented the lipid accumulation induced by miR-149-5p mimics.	Uric Acid	78-87	fibroblast growth factor 21	Mus musculus	10-15
32070295-11	2020	CONCLUSIONS: Uric acid significantly up-regulated the expression of miR-149-5p in hepatocytes and induced hepatocytes lipid accumulation via regulation of miR-149-5p/FGF21 axis.	Uric Acid	13-22	fibroblast growth factor 21	Mus musculus	166-171
31760766-9	2020	RNA-seq analysis revealed that alcohol feeding increases expression of markers for tumors (Epcam, Krt19, Prom1, Wt1, and Wwtr1), stroma (Dcn, Fn1, and Tnc), and cytokines (Tgfb1 and Tnf) and decreases expression of Fgf21 and Il6 in the pancreatic tumor tissues.	Alcohols	31-38	fibroblast growth factor 21	Mus musculus	215-220
32054022-8	2020	In HRMECs in vitro, FGF21 versus vehicle prevented hVEGF-induced increase in cell permeability, identified with FITC-dextran.	fluorescein isothiocyanate dextran	112-124	fibroblast growth factor 21	Mus musculus	20-25
31848393-6	2019	Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels.	Norepinephrine	253-265	fibroblast growth factor 21	Mus musculus	21-26
31701691-9	2020	Moreover pifithrin-alpha inhibited the FGF21-induced preventive effects on the renal EMT and subsequent renal fibrosis in DN mice.	pifithrin	9-24	fibroblast growth factor 21	Mus musculus	39-44
32025205-1	2020	Fenofibrate (FF) protects against diabetic nephropathy (DN) in type 1 diabetic (T1D) mice by upregulating the expression of fibroblast growth factor 21 (FGF21), leading to the activation of the Akt-mediated Nrf2 antioxidant pathways.	Fenofibrate	0-11	fibroblast growth factor 21	Mus musculus	124-151
32025205-1	2020	Fenofibrate (FF) protects against diabetic nephropathy (DN) in type 1 diabetic (T1D) mice by upregulating the expression of fibroblast growth factor 21 (FGF21), leading to the activation of the Akt-mediated Nrf2 antioxidant pathways.	Fenofibrate	0-11	fibroblast growth factor 21	Mus musculus	153-158
32025205-1	2020	Fenofibrate (FF) protects against diabetic nephropathy (DN) in type 1 diabetic (T1D) mice by upregulating the expression of fibroblast growth factor 21 (FGF21), leading to the activation of the Akt-mediated Nrf2 antioxidant pathways.	Fenofibrate	13-15	fibroblast growth factor 21	Mus musculus	124-151
32025205-1	2020	Fenofibrate (FF) protects against diabetic nephropathy (DN) in type 1 diabetic (T1D) mice by upregulating the expression of fibroblast growth factor 21 (FGF21), leading to the activation of the Akt-mediated Nrf2 antioxidant pathways.	Fenofibrate	13-15	fibroblast growth factor 21	Mus musculus	153-158
32025205-2	2020	Here, we examined which isoforms of Akt contribute to FF activation of FGF21-mediated renal protection by examining the phosphorylation and expression of three isoforms, Akt1, Akt2, and Akt3.	Fenofibrate	54-56	fibroblast growth factor 21	Mus musculus	71-76
32025205-9	2020	These results suggest that FF protects against DN through FGF21 to activate both Akt2/GSK-3beta/Fyn/Nrf2 antioxidants and the AMPK pathway.	Fenofibrate	27-29	fibroblast growth factor 21	Mus musculus	58-63
31399953-6	2020	Furthermore, specific modifications in the FGF21 activation after treatment with 11beta-HSD1i, RL-118, which induced changes in SIRT1/PGC1alpha/AMPKalpha pathway, were found.	rl-118	95-101	fibroblast growth factor 21	Mus musculus	43-48
31921941-2	2020	Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism.	Methionine	34-44	fibroblast growth factor 21	Mus musculus	120-125
31921941-13	2020	The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.	Methionine	42-52	fibroblast growth factor 21	Mus musculus	29-34
31921941-13	2020	The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.	Cystine	84-91	fibroblast growth factor 21	Mus musculus	29-34
31690632-7	2019	The enhanced glucose uptake correlated with increased liver expression and elevated plasma levels of fibroblast growth factor 21 (FGF21), a hepatokine known to increase systemic insulin sensitivity and to regulate whole-body lipid metabolism.	Glucose	13-20	fibroblast growth factor 21	Mus musculus	101-128
31690632-7	2019	The enhanced glucose uptake correlated with increased liver expression and elevated plasma levels of fibroblast growth factor 21 (FGF21), a hepatokine known to increase systemic insulin sensitivity and to regulate whole-body lipid metabolism.	Glucose	13-20	fibroblast growth factor 21	Mus musculus	130-135
31690632-8	2019	Feeding LKO mice with triolein-supplemented, but not tristearin-supplemented, HCD reduced FGF21 expression and plasma levels.	Triolein	22-30	fibroblast growth factor 21	Mus musculus	90-95
31690632-9	2019	Consistently, SCD1 inhibition in primary hepatocytes induced FGF21 expression, which was repressed by treatment with oleate but not palmitoleate.	Oleic Acid	117-123	fibroblast growth factor 21	Mus musculus	61-66
31690632-11	2019	These results suggest that hepatic oleate regulates glucose uptake in adipose tissue either directly or partially by modulating the hepatic PGC-1alpha-FGF21 axis.	Oleic Acid	35-41	fibroblast growth factor 21	Mus musculus	151-156
31690632-11	2019	These results suggest that hepatic oleate regulates glucose uptake in adipose tissue either directly or partially by modulating the hepatic PGC-1alpha-FGF21 axis.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	151-156
31848393-6	2019	Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels.	Corticosterone	270-284	fibroblast growth factor 21	Mus musculus	21-26
31548064-5	2019	Mice experiencing increased hepatic fatty acid flux are protected from this condition through coordinated actions of the newly described hormone fibroblast growth factor-21 (FGF21) on liver and adipose tissue.	Fatty Acids	36-46	fibroblast growth factor 21	Mus musculus	145-172
31548064-5	2019	Mice experiencing increased hepatic fatty acid flux are protected from this condition through coordinated actions of the newly described hormone fibroblast growth factor-21 (FGF21) on liver and adipose tissue.	Fatty Acids	36-46	fibroblast growth factor 21	Mus musculus	174-179
31020790-10	2019	In addition to enhancing BAT activity, CL316,243 significantly increased serum adiponectin concentrations and renal Fgf21 sensitivity, and reactivated the renal AMPK/Sirt1/Pgc1alpha signaling pathway.	cl316	39-44	fibroblast growth factor 21	Mus musculus	116-121
31771164-0	2019	Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model.	(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid	0-11	fibroblast growth factor 21	Mus musculus	75-80
31783664-5	2019	Fasting (24 h) induced increase in hepatic Fgf21 gene expression, which was associated with elevation of plasma FGF21 and adiponectin levels, and the upregulation of expression of hepatic (Pparalpha, Cpt1alpha) and muscle (Cpt1beta, Ucp3) genes involved in fatty acid oxidation.	Fatty Acids	257-267	fibroblast growth factor 21	Mus musculus	43-48
31771164-0	2019	Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model.	Oxygen	99-105	fibroblast growth factor 21	Mus musculus	75-80
31723038-5	2019	The higher concentration of gut microbiota-derived butyrate in these young transplanted mice was associated with an increase in the pleiotropic and prolongevity hormone fibroblast growth factor 21 (FGF21).	Butyrates	51-59	fibroblast growth factor 21	Mus musculus	169-196
31723038-5	2019	The higher concentration of gut microbiota-derived butyrate in these young transplanted mice was associated with an increase in the pleiotropic and prolongevity hormone fibroblast growth factor 21 (FGF21).	Butyrates	51-59	fibroblast growth factor 21	Mus musculus	198-203
31474567-4	2019	Fasting, likely via the increase in circulating fatty acids, regulates this central Fgf21 production.	Fatty Acids	48-59	fibroblast growth factor 21	Mus musculus	84-89
31668386-1	2019	OBJECTIVES: High fructose feeding changes fibroblast growth factor 21 (FGF21) regulation.	Fructose	17-25	fibroblast growth factor 21	Mus musculus	71-76
31668386-7	2019	RESULTS: FGF21 expression was robustly increased after 5-weeks of feeding and significantly decreased after 12-weeks of feeding in fructose-induced NAFLD mice.	Fructose	131-139	fibroblast growth factor 21	Mus musculus	9-14
31668386-17	2019	Thus, our data suggest that FGF21 is required for the beneficial effects of LGG in reversal of fructose-induced NAFLD.	Fructose	95-103	fibroblast growth factor 21	Mus musculus	28-33
31654570-7	2019	FGF21 ameliorated PA-induced lipid accumulation, reversed cell apoptosis, and enhanced glucose-stimulated insulin secretion (GSIS) as impaired by lipotoxicity in islet beta-cells.	Palmitic Acid	18-20	fibroblast growth factor 21	Mus musculus	0-5
31654570-7	2019	FGF21 ameliorated PA-induced lipid accumulation, reversed cell apoptosis, and enhanced glucose-stimulated insulin secretion (GSIS) as impaired by lipotoxicity in islet beta-cells.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	0-5
31654570-8	2019	Mechanistically, FGF21 exerted its beneficial effects through activation of AMPK-ACC (acetyl-CoA carboxylase) pathway and peroxisome proliferation-activated receptors (PPARs) delta/gamma signaling, thus increasing the levels of carnitine palmitoyltransferase-1A (CPT1A) and leading to increased fatty acid (FA) oxidation and reduced lipid deposition in beta-cells.	Fatty Acids	295-305	fibroblast growth factor 21	Mus musculus	17-22
31654570-9	2019	Interestingly, FGF21 reduced PA-induced cell death via restoration of the expression of apoptosis inhibitor Birc3.	Palmitic Acid	29-31	fibroblast growth factor 21	Mus musculus	15-20
30890204-0	2019	Sterol 12alpha-Hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP-1C Pathway via FGF21 and FGF15.	Ceramides	69-77	fibroblast growth factor 21	Mus musculus	106-111
31352001-19	2019	FGF21 also reduces the GTP binding capacity of RAS.	Guanosine Triphosphate	23-26	fibroblast growth factor 21	Mus musculus	0-5
31474567-5	2019	Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure.	Palmitates	16-25	fibroblast growth factor 21	Mus musculus	182-187
31474567-5	2019	Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure.	Reactive Oxygen Species	91-114	fibroblast growth factor 21	Mus musculus	182-187
31474567-5	2019	Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure.	Reactive Oxygen Species	116-119	fibroblast growth factor 21	Mus musculus	182-187
31474567-5	2019	Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure.	Palmitates	204-213	fibroblast growth factor 21	Mus musculus	182-187
31474567-8	2019	Our results suggest that tanycytes sense free fatty acids to maintain body lipid homeostasis through Fgf21 signaling within the hypothalamus.	Fatty Acids, Nonesterified	41-57	fibroblast growth factor 21	Mus musculus	101-106
31317231-5	2019	RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis.	Norepinephrine	182-195	fibroblast growth factor 21	Mus musculus	243-248
31120577-0	2019	Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers.	Valproic Acid	54-67	fibroblast growth factor 21	Mus musculus	23-50
31570705-0	2019	Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation.	Dichloroacetic Acid	22-37	fibroblast growth factor 21	Mus musculus	74-79
31570705-6	2019	In addition, we found that DCA stimulated hepatic fibroblast growth factor 21 (Fgf21) mRNA expression, which might be important for lowering lipid levels and insulin sensitization via BAT activation, in a dose- and time-dependent manner associated with serum FGF21 levels.	Dichloroacetic Acid	27-30	fibroblast growth factor 21	Mus musculus	50-77
31570705-6	2019	In addition, we found that DCA stimulated hepatic fibroblast growth factor 21 (Fgf21) mRNA expression, which might be important for lowering lipid levels and insulin sensitization via BAT activation, in a dose- and time-dependent manner associated with serum FGF21 levels.	Dichloroacetic Acid	27-30	fibroblast growth factor 21	Mus musculus	79-84
31570705-6	2019	In addition, we found that DCA stimulated hepatic fibroblast growth factor 21 (Fgf21) mRNA expression, which might be important for lowering lipid levels and insulin sensitization via BAT activation, in a dose- and time-dependent manner associated with serum FGF21 levels.	Dichloroacetic Acid	27-30	fibroblast growth factor 21	Mus musculus	259-264
31570705-7	2019	Interestingly, Fgf21 mRNA expression was mediated in an AMP-activated protein kinase (AMPK)-dependent manner within several minutes after DCA treatment independent of peroxisome proliferator-activated receptor alpha (PPARalpha).	Dichloroacetic Acid	138-141	fibroblast growth factor 21	Mus musculus	15-20
31511499-7	2019	In vitro, we identified a direct action of FGF21 on endothelial cells of the aorta, in which it bounds to FGF receptors to alleviate impaired endothelial function challenged with high glucose.	Glucose	184-191	fibroblast growth factor 21	Mus musculus	43-48
31570705-8	2019	Taken together, the results suggest that enhanced glucose oxidation by DCA protects against atherosclerosis by inducing hepatic FGF21 expression and BAT activation, resulting in augmented energy expenditure for heat generation.	Glucose	50-57	fibroblast growth factor 21	Mus musculus	128-133
31570705-8	2019	Taken together, the results suggest that enhanced glucose oxidation by DCA protects against atherosclerosis by inducing hepatic FGF21 expression and BAT activation, resulting in augmented energy expenditure for heat generation.	Dichloroacetic Acid	71-74	fibroblast growth factor 21	Mus musculus	128-133
31336365-9	2019	I/R or OGD/R significantly increased the expressions of AK005401and YY1 and decreased FGF21expression, which further attenuated the activation of PI3K/Akt, promoted reactive oxygen species (ROS) generation, and then caused mitochondria dysfunction and cell apoptosis, which were reversed by AK005401 siRNA oligos and were aggravated by overexpression of AK005401 and YY1.	Reactive Oxygen Species	165-188	fibroblast growth factor 21	Mus musculus	86-91
31176759-5	2019	Amelioration of NAFLD in adipoWT mice promoted by pioglitazone was associated with up-regulation of Pparg, Fgf21 and down-regulation of Pepck liver expression.	Pioglitazone	50-62	fibroblast growth factor 21	Mus musculus	107-112
31241990-10	2019	Fibroblast growth factor 21, an endocrine regulator of sweetness preference, was significantly higher in female CDNOS1KO mice, suggesting that this was reducing their drive to drink the sucrose water.	Sucrose	186-193	fibroblast growth factor 21	Mus musculus	0-27
31241990-10	2019	Fibroblast growth factor 21, an endocrine regulator of sweetness preference, was significantly higher in female CDNOS1KO mice, suggesting that this was reducing their drive to drink the sucrose water.	Water	194-199	fibroblast growth factor 21	Mus musculus	0-27
31175853-6	2019	Thus, the present study was undertaken to detect the effects of FGF-21 on l-arginine induced chronic pancreatitis/islet fibrosis in mice.	Arginine	74-84	fibroblast growth factor 21	Mus musculus	64-70
31207147-11	2019	FGF21 administration reduced hepatic lipids and blood glucose concentrations.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	0-5
31336365-9	2019	I/R or OGD/R significantly increased the expressions of AK005401and YY1 and decreased FGF21expression, which further attenuated the activation of PI3K/Akt, promoted reactive oxygen species (ROS) generation, and then caused mitochondria dysfunction and cell apoptosis, which were reversed by AK005401 siRNA oligos and were aggravated by overexpression of AK005401 and YY1.	Reactive Oxygen Species	190-193	fibroblast growth factor 21	Mus musculus	86-91
30978696-3	2019	The FGF21-adiponectin axis participates in the regulation of glucose metabolism.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	4-9
30677512-9	2019	Consequently, FGF21 promoted the activation of the LKB1 target adenosine monophosphate-activated protein kinase (AMPK) and altered the transcriptional activity of FoxO1 on its downstream target genes catalase (Cat), MnSOD (Sod2), and Bim, resulting in reduced reactive oxygen species (ROS) accumulation and cardiomyocyte apoptosis.	Reactive Oxygen Species	260-283	fibroblast growth factor 21	Mus musculus	14-19
30677512-9	2019	Consequently, FGF21 promoted the activation of the LKB1 target adenosine monophosphate-activated protein kinase (AMPK) and altered the transcriptional activity of FoxO1 on its downstream target genes catalase (Cat), MnSOD (Sod2), and Bim, resulting in reduced reactive oxygen species (ROS) accumulation and cardiomyocyte apoptosis.	Reactive Oxygen Species	285-288	fibroblast growth factor 21	Mus musculus	14-19
31121855-7	2019	RESULTS: HFD-treated mice showed increases in fasting plasma glucose, body weight and impaired glucose tolerance; islet protein expression of FGF21 was induced after HFD treatment.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	142-147
31121855-8	2019	Protein expression levels of FGF21 and LC3-II (autophagy marker) were induced in mouse islets treated with high concentrations of palmitic acid and glucose, while phosphorylation of AMPK was reduced, compared with controls.	Palmitic Acid	130-143	fibroblast growth factor 21	Mus musculus	29-34
31121855-8	2019	Protein expression levels of FGF21 and LC3-II (autophagy marker) were induced in mouse islets treated with high concentrations of palmitic acid and glucose, while phosphorylation of AMPK was reduced, compared with controls.	Glucose	148-155	fibroblast growth factor 21	Mus musculus	29-34
30735436-0	2019	Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice.	Methionine	16-26	fibroblast growth factor 21	Mus musculus	95-100
30735436-0	2019	Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice.	Starch	33-39	fibroblast growth factor 21	Mus musculus	95-100
30735436-8	2019	In plasma, when protein was decreased, insulin-like growth factor-1 decreased and FGF21 increased and plasma FGF21 was best described by using a combination of dietary protein level, protein-to-carbohydrate ratio, and protein-to-methionine ratio in the diet.	Carbohydrates	194-206	fibroblast growth factor 21	Mus musculus	109-114
30735436-8	2019	In plasma, when protein was decreased, insulin-like growth factor-1 decreased and FGF21 increased and plasma FGF21 was best described by using a combination of dietary protein level, protein-to-carbohydrate ratio, and protein-to-methionine ratio in the diet.	Methionine	229-239	fibroblast growth factor 21	Mus musculus	109-114
30735436-10	2019	In this process, FGF21 is probably an important signal that responds to a complex combination of protein restriction, protein quality, and carbohydrate content of the diet.	Carbohydrates	139-151	fibroblast growth factor 21	Mus musculus	17-22
31289229-1	2019	Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis.	Glucose	75-82	fibroblast growth factor 21	Mus musculus	0-27
31289229-1	2019	Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis.	Glucose	75-82	fibroblast growth factor 21	Mus musculus	29-34
30920846-0	2019	Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.	Serine	11-17	fibroblast growth factor 21	Mus musculus	48-53
30920846-3	2019	We reasoned that CS creates an apparent dietary protein restriction, which is known to increase hepatic fibroblast growth factor 21 (FGF21).	camostat	17-19	fibroblast growth factor 21	Mus musculus	104-131
30920846-8	2019	In lean mice, CS increased liver FGF21 mRNA and plasma levels.	camostat	14-16	fibroblast growth factor 21	Mus musculus	33-38
30842568-3	2019	The expression levels of hepatic Fgf21, Btg2, and Klf15, and the production of serum FGF21 increased significantly in fasted and forskolin (FSK)-treated mice.	Colforsin	129-138	fibroblast growth factor 21	Mus musculus	33-38
30802283-6	2019	In a series of behavioral tests, we isolated the effect of FGF21 to influence consumption of protein, fat, and carbohydrate in male mice.	Carbohydrates	111-123	fibroblast growth factor 21	Mus musculus	59-64
30802283-8	2019	In response to FGF21, mice increased consumption of protein while reducing carbohydrate intake, with no effect on fat intake.	Carbohydrates	75-87	fibroblast growth factor 21	Mus musculus	15-20
30802283-11	2019	Under these conditions, FGF21 increased protein intake, and this was offset by reducing the consumption of either carbohydrate or fat.	Carbohydrates	114-126	fibroblast growth factor 21	Mus musculus	24-29
30790712-5	2019	BPA increased all-trans-retinoic acid concentration and expression of Adh1, Aox1 and Cyp1a2 (biosynthesis of retinoic acid), while reduced Mrp3 (efflux from hepatocyte to blood), increased Bcrp expression (biliary excretion) and changed the retinoid-dependent signalling system after reducing expression of Rxrbeta and increasing that of Fgf21.	bisphenol A	0-3	fibroblast growth factor 21	Mus musculus	338-343
30770297-9	2019	Finally, RSCE increased plasma levels of fibroblast growth factor 21 (FGF21), a batokine, which inversely correlated with hippocampal tau phosphorylation.	batokine	80-88	fibroblast growth factor 21	Mus musculus	41-68
30770297-9	2019	Finally, RSCE increased plasma levels of fibroblast growth factor 21 (FGF21), a batokine, which inversely correlated with hippocampal tau phosphorylation.	batokine	80-88	fibroblast growth factor 21	Mus musculus	70-75
30022432-3	2019	Fibroblast growth factor 21 (FGF21) is a potent regulator of lipid and glucose metabolism.	Glucose	71-78	fibroblast growth factor 21	Mus musculus	0-27
30022432-3	2019	Fibroblast growth factor 21 (FGF21) is a potent regulator of lipid and glucose metabolism.	Glucose	71-78	fibroblast growth factor 21	Mus musculus	29-34
30842568-3	2019	The expression levels of hepatic Fgf21, Btg2, and Klf15, and the production of serum FGF21 increased significantly in fasted and forskolin (FSK)-treated mice.	Colforsin	129-138	fibroblast growth factor 21	Mus musculus	85-90
30842568-3	2019	The expression levels of hepatic Fgf21, Btg2, and Klf15, and the production of serum FGF21 increased significantly in fasted and forskolin (FSK)-treated mice.	Colforsin	140-143	fibroblast growth factor 21	Mus musculus	33-38
30842568-3	2019	The expression levels of hepatic Fgf21, Btg2, and Klf15, and the production of serum FGF21 increased significantly in fasted and forskolin (FSK)-treated mice.	Colforsin	140-143	fibroblast growth factor 21	Mus musculus	85-90
30842568-7	2019	Similarly, the FSK-mediated induction of Fgf21 promoter activity was strikingly ablated by silencing of Btg2 and Klf15.	Colforsin	15-18	fibroblast growth factor 21	Mus musculus	41-46
30841429-8	2019	Metformin also enhanced thermogenic markers in the BAT (uncoupling protein type 1, peroxisome proliferator-activated receptor gamma coactivator-1 alpha) through adrenergic stimuli and fibroblast growth factor 21.	Metformin	0-9	fibroblast growth factor 21	Mus musculus	184-211
30551357-6	2019	The results showed that FGF-21 improved glucose homeostasis, inhibited intestinal glucose uptake and reduced intestinal SGLT1 expression compared with insulin in db/db mice.	Glucose	40-47	fibroblast growth factor 21	Mus musculus	24-30
30827929-8	2019	FINDINGS: Utilizing the cytokine array, we identified that FGF21 secretion was upregulated by exenatide (exendin-4).	Exenatide	94-103	fibroblast growth factor 21	Mus musculus	59-64
30827929-8	2019	FINDINGS: Utilizing the cytokine array, we identified that FGF21 secretion was upregulated by exenatide (exendin-4).	Exenatide	105-114	fibroblast growth factor 21	Mus musculus	59-64
30827929-9	2019	Similarly, FGF21 production in hepatocytes was stimulated by exenatide or liraglutide.	Exenatide	61-70	fibroblast growth factor 21	Mus musculus	11-16
30703283-4	2019	METHODS: Monosodium glutamate (MSG) was used to induce obesity in mice and subsequently treated the mice with or without FGF-21.	Sodium Glutamate	9-29	fibroblast growth factor 21	Mus musculus	121-127
30703283-4	2019	METHODS: Monosodium glutamate (MSG) was used to induce obesity in mice and subsequently treated the mice with or without FGF-21.	Sodium Glutamate	31-34	fibroblast growth factor 21	Mus musculus	121-127
30703283-10	2019	CONCLUSIONS: Our study showed that FGF-21-induced glucose uptake and FGF-21-related anti-inflammatory effects are mediated by different signaling pathways.	Glucose	50-57	fibroblast growth factor 21	Mus musculus	35-41
30535435-9	2019	Conversely, augmentation of miR-100-5p using a specific agomir in OVX-operated mice decreased the levels of FGF21 in the serum and liver, and prevented osteoclastogenesis and bone loss.	mir-100-5p	28-38	fibroblast growth factor 21	Mus musculus	108-113
30461198-1	2019	Fibroblast growth factor 21 (FGF21) is important in glucose, lipid homeostasis and insulin sensitivity.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	0-27
30461198-1	2019	Fibroblast growth factor 21 (FGF21) is important in glucose, lipid homeostasis and insulin sensitivity.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	29-34
30461198-4	2019	Importantly, FGF21 knockout exacerbated palmitate-induced islet beta-cell failure and suppression of glucose-stimulated insulin secretion (GSIS).	Palmitates	40-49	fibroblast growth factor 21	Mus musculus	13-18
30461198-4	2019	Importantly, FGF21 knockout exacerbated palmitate-induced islet beta-cell failure and suppression of glucose-stimulated insulin secretion (GSIS).	Glucose	101-108	fibroblast growth factor 21	Mus musculus	13-18
30399586-2	2019	In the present study, the synthetic RORalpha/gamma agonist SR1078 stimulated the production and gene expression of fibroblast growth factor 21 (FGF21) in C2C12 myotubes.	SR 1078	59-65	fibroblast growth factor 21	Mus musculus	115-142
30399586-2	2019	In the present study, the synthetic RORalpha/gamma agonist SR1078 stimulated the production and gene expression of fibroblast growth factor 21 (FGF21) in C2C12 myotubes.	SR 1078	59-65	fibroblast growth factor 21	Mus musculus	144-149
30399586-3	2019	FGF21, a member of the FGF family, plays important roles in the regulation of peripheral glucose tolerance and lipid metabolism and improves metabolic health.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	0-5
30399586-3	2019	FGF21, a member of the FGF family, plays important roles in the regulation of peripheral glucose tolerance and lipid metabolism and improves metabolic health.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	0-3
30551357-9	2019	Our results showed that FGF-21 inhibited glucose uptake and reduced SGLT1 expression in MODE-K cells, which were due to inactivating SGK-1 pathway.	Glucose	41-48	fibroblast growth factor 21	Mus musculus	24-30
30399586-9	2019	Collectively, these results suggest that baicalein stimulates the ER stress response and FGF21 expression through an RORalpha-dependent mechanism in C2C12 myotubes, and indicate the potential of baicalein as an effective anti-obesity therapy via its ability to enhance FGF21 production.	baicalein	41-50	fibroblast growth factor 21	Mus musculus	89-94
30399586-9	2019	Collectively, these results suggest that baicalein stimulates the ER stress response and FGF21 expression through an RORalpha-dependent mechanism in C2C12 myotubes, and indicate the potential of baicalein as an effective anti-obesity therapy via its ability to enhance FGF21 production.	baicalein	41-50	fibroblast growth factor 21	Mus musculus	269-274
30551357-10	2019	Moreover, above effects of FGF-21 on MODE-K cells were abolished by PD173074, a FGFR1 inhibitor.	PD 173074	68-76	fibroblast growth factor 21	Mus musculus	27-33
30399586-9	2019	Collectively, these results suggest that baicalein stimulates the ER stress response and FGF21 expression through an RORalpha-dependent mechanism in C2C12 myotubes, and indicate the potential of baicalein as an effective anti-obesity therapy via its ability to enhance FGF21 production.	baicalein	195-204	fibroblast growth factor 21	Mus musculus	269-274
30551357-11	2019	In conclusion, FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway.	Glucose	32-39	fibroblast growth factor 21	Mus musculus	15-21
30551357-11	2019	In conclusion, FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway.	Glucose	86-93	fibroblast growth factor 21	Mus musculus	15-21
30551357-12	2019	These results expand our knowledge about how FGF-21 regulates glucose metabolism.	Glucose	62-69	fibroblast growth factor 21	Mus musculus	45-51
30385734-6	2018	The PR-mediated increase in Apoa5 expression was controlled by the transcription factor CREBH, which coordinately regulated hepatic expression of fatty acid oxidation-related genes, including Fgf21 and Ppara.	Fatty Acids	146-156	fibroblast growth factor 21	Mus musculus	192-197
30389922-6	2018	The hepatokine FGF21 acts as an endocrine signal to oxytocin neurons, promoting neuronal activation and Oxt transcription and suppressing the simple sugar preference.	Sugars	149-154	fibroblast growth factor 21	Mus musculus	15-20
30909226-4	2019	In addition, it is known that metformin upregulates Fgf21, which in turn activates the AMPK/mTOR pathway and mediates neuroprotection.	Metformin	30-39	fibroblast growth factor 21	Mus musculus	52-57
30909226-5	2019	Thus, metformin-induced Fgf21 release may be involved in AMPK/mTOR activation.	Metformin	6-15	fibroblast growth factor 21	Mus musculus	24-29
30227329-0	2018	Fibroblast growth factor 21 regulates glucose metabolism in part by reducing renal glucose reabsorption.	Glucose	38-45	fibroblast growth factor 21	Mus musculus	0-27
30227329-4	2018	Administration of type 2 and type 1 diabetic mice with FGF21 reduced the transport maximum of glucose in the kidney and enhanced urinary glucose excretion in a dose-dependent manner.	Glucose	94-101	fibroblast growth factor 21	Mus musculus	55-60
30389664-7	2018	HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis.	Lysine	60-66	fibroblast growth factor 21	Mus musculus	229-234
29718710-0	2018	Identification of hepatic fibroblast growth factor 21 as a mediator in 17beta-estradiol-induced white adipose tissue browning.	Estradiol	71-87	fibroblast growth factor 21	Mus musculus	26-53
29702025-17	2018	FGF21 is upregulated in response to oxidative stress and mediates the effects of DEPP on fatty acid oxidation, ketogenesis, and lipid synthesis but not gluconeogenesis, as evidenced by the fact that the FGF21 antibody dramatically suppressed a DEPP-induced increase of fatty acid oxidation and ketogenesis, reversed the reduction of lipid synthesis, but did not change the suppression of gluconeogenesis.	Fatty Acids	89-99	fibroblast growth factor 21	Mus musculus	0-5
29702025-17	2018	FGF21 is upregulated in response to oxidative stress and mediates the effects of DEPP on fatty acid oxidation, ketogenesis, and lipid synthesis but not gluconeogenesis, as evidenced by the fact that the FGF21 antibody dramatically suppressed a DEPP-induced increase of fatty acid oxidation and ketogenesis, reversed the reduction of lipid synthesis, but did not change the suppression of gluconeogenesis.	Fatty Acids	269-279	fibroblast growth factor 21	Mus musculus	0-5
29702025-17	2018	FGF21 is upregulated in response to oxidative stress and mediates the effects of DEPP on fatty acid oxidation, ketogenesis, and lipid synthesis but not gluconeogenesis, as evidenced by the fact that the FGF21 antibody dramatically suppressed a DEPP-induced increase of fatty acid oxidation and ketogenesis, reversed the reduction of lipid synthesis, but did not change the suppression of gluconeogenesis.	Fatty Acids	269-279	fibroblast growth factor 21	Mus musculus	203-208
30382123-6	2018	Remarkably, VCE-004.8 increased the FGF21 mRNA expression in white and brown adipose, as well as in a BAT cell line, qualifying cannabinoaminoquinones as a class of novel therapeutic candidates for the management of obesity and its common metabolic co-morbidities.	cannabinoaminoquinones	128-150	fibroblast growth factor 21	Mus musculus	36-41
29702025-0	2018	DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.	Glucose	38-45	fibroblast growth factor 21	Mus musculus	88-93
29980484-6	2018	Plasma FGF21 levels were substantially increased and associated with expression of genes involved in fatty acid oxidation and formation of brown-like adipocytes.	Fatty Acids	101-111	fibroblast growth factor 21	Mus musculus	7-12
29702025-0	2018	DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.	Reactive Oxygen Species	76-79	fibroblast growth factor 21	Mus musculus	88-93
29702025-19	2018	Hepatic overexpression of DEPP in mice promotes fatty acid oxidation and ketogenesis and suppresses lipogenesis and gluconeogenesis, which is partly mediated by FGF21 induced by elevated cellular ROS levels.-Li, W., Ji, M., Lin, Y., Miao, Y., Chen, S., Li, H. DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.	Reactive Oxygen Species	196-199	fibroblast growth factor 21	Mus musculus	161-166
29898429-7	2018	In in vitro experiments, Cy-3-G inhibited the release of adipokines including extracellular nicotinamide phosphoribosyltransferase (eNAMPT) and fibroblast growth factor 21 (FGF21) from differentiated C3H10T1/2 clone8 cells induced by palmitate, which was accompanied by a reduction of lipid accumulation in HepG2 cells and LO2 cells cultured by the corresponding collected media of C3H10T1/2 clone8 cells.	cyanidin-3-o-glucoside	25-31	fibroblast growth factor 21	Mus musculus	144-171
30127091-3	2018	Despite the physiological role of FGF21 and FGF19 being quite different, both lower blood glucose (BG) when administered to diabetic mice.	Blood Glucose	84-97	fibroblast growth factor 21	Mus musculus	34-39
30127091-3	2018	Despite the physiological role of FGF21 and FGF19 being quite different, both lower blood glucose (BG) when administered to diabetic mice.	Blood Glucose	99-101	fibroblast growth factor 21	Mus musculus	34-39
29730296-0	2018	FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice.	Fenofibrate	40-51	fibroblast growth factor 21	Mus musculus	0-5
29730296-0	2018	FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice.	Acetaminophen	60-73	fibroblast growth factor 21	Mus musculus	0-5
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Fenofibrate	115-126	fibroblast growth factor 21	Mus musculus	51-78
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Fenofibrate	115-126	fibroblast growth factor 21	Mus musculus	80-85
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Acetaminophen	212-225	fibroblast growth factor 21	Mus musculus	51-78
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Acetaminophen	212-225	fibroblast growth factor 21	Mus musculus	80-85
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Acetaminophen	227-231	fibroblast growth factor 21	Mus musculus	51-78
29730296-3	2018	The aim of present study is to explore the role of fibroblast growth factor 21 (FGF21) in the protective effect of fenofibrate, an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), against acetaminophen (APAP)-induced liver injury.	Acetaminophen	227-231	fibroblast growth factor 21	Mus musculus	80-85
29730296-5	2018	FGF21 deficient mice were used to evaluate the role of FGF21 in fenofibrate against APAP-induced acute liver injury.	Fenofibrate	64-75	fibroblast growth factor 21	Mus musculus	55-60
29730296-6	2018	Post-treatment with fenofibrate significantly inhibits APAP-induced hepatotoxicity, as evidenced by decreased serum ALT and AST levels and hepatic necrosis in liver tissue as well as increased the surviving rate in response to APAP overdose, whereas this protective effect of fenofibrate is largely attenuated in FGF21 KO mice.	Fenofibrate	20-31	fibroblast growth factor 21	Mus musculus	313-318
29730296-6	2018	Post-treatment with fenofibrate significantly inhibits APAP-induced hepatotoxicity, as evidenced by decreased serum ALT and AST levels and hepatic necrosis in liver tissue as well as increased the surviving rate in response to APAP overdose, whereas this protective effect of fenofibrate is largely attenuated in FGF21 KO mice.	Acetaminophen	55-59	fibroblast growth factor 21	Mus musculus	313-318
29730296-8	2018	However, such effect is significantly attenuated in APAP-treated FGF21 KO mice.	Acetaminophen	52-56	fibroblast growth factor 21	Mus musculus	65-70
29730296-9	2018	In conclusion, our findings suggest that fenofibrate against APAP-induced hepatotoxicity is at least in part mediated by up-regulating the expression of FGF21, which in turn promotes autophagy-mediated hepatoprotective effects.	Fenofibrate	41-52	fibroblast growth factor 21	Mus musculus	153-158
29730296-9	2018	In conclusion, our findings suggest that fenofibrate against APAP-induced hepatotoxicity is at least in part mediated by up-regulating the expression of FGF21, which in turn promotes autophagy-mediated hepatoprotective effects.	Acetaminophen	61-65	fibroblast growth factor 21	Mus musculus	153-158
29898429-7	2018	In in vitro experiments, Cy-3-G inhibited the release of adipokines including extracellular nicotinamide phosphoribosyltransferase (eNAMPT) and fibroblast growth factor 21 (FGF21) from differentiated C3H10T1/2 clone8 cells induced by palmitate, which was accompanied by a reduction of lipid accumulation in HepG2 cells and LO2 cells cultured by the corresponding collected media of C3H10T1/2 clone8 cells.	cyanidin-3-o-glucoside	25-31	fibroblast growth factor 21	Mus musculus	173-178
29898429-7	2018	In in vitro experiments, Cy-3-G inhibited the release of adipokines including extracellular nicotinamide phosphoribosyltransferase (eNAMPT) and fibroblast growth factor 21 (FGF21) from differentiated C3H10T1/2 clone8 cells induced by palmitate, which was accompanied by a reduction of lipid accumulation in HepG2 cells and LO2 cells cultured by the corresponding collected media of C3H10T1/2 clone8 cells.	Palmitates	234-243	fibroblast growth factor 21	Mus musculus	173-178
29864937-2	2018	Fibroblast growth factor 21 (FGF21) is a promising pleiotropic regulator in glucolipid metabolism.	glucolipid	76-86	fibroblast growth factor 21	Mus musculus	0-27
29925501-1	2018	Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion.	Glucagon	0-8	fibroblast growth factor 21	Mus musculus	125-152
29925501-1	2018	Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part through potentiation of fibroblast growth factor 21 (FGF21) secretion.	Glucagon	0-8	fibroblast growth factor 21	Mus musculus	154-159
30214638-8	2018	Microarray analyses revealed that FGF21 controlled the expression of cardiomyocyte genes that are involved in cholesterol homeostasis, DNA repair, peroxisome, oxidative phosphorylation, glycolysis, apoptosis, and steroid responses, all of which are responsible for cardiomyocyte survival.	Steroids	213-220	fibroblast growth factor 21	Mus musculus	34-39
29859019-10	2018	KEY RESULTS: PsTag600-FGF21 dose-dependently reduced body weight, blood glucose, and insulin and lipid levels and reversed hepatic steatosis.	Glucose	72-79	fibroblast growth factor 21	Mus musculus	22-27
29859019-11	2018	PsTag600-FGF21 enhanced fatty acid activation and mitochondrial beta-oxidation in the liver.	Fatty Acids	24-34	fibroblast growth factor 21	Mus musculus	9-14
29866659-7	2018	These data identify Plin2 actions as novel mediators of sugar-induced adipose browning through indirect effects of hepatic FGF21 expression, and suggest that adipose browning mechanisms may contribute to Plin2-null resistance to obesity.	Sugars	56-61	fibroblast growth factor 21	Mus musculus	123-128
30157856-0	2018	Fibroblast growth factor 21 inhibits atherosclerosis in apoE-/- mice by ameliorating Fas-mediated apoptosis.	ammonium ferrous sulfate	85-88	fibroblast growth factor 21	Mus musculus	0-27
30157856-1	2018	BACKGROUND: FGF21 is a critical endogenous regulator in energy homeostasis and systemic glucose and lipid metabolism.	Glucose	88-95	fibroblast growth factor 21	Mus musculus	12-17
30157856-8	2018	FGF21 suppressed the development of atherosclerosis, and the administration of FGF21 ameliorated Fas-mediated apoptosis in apoE-/- mice.	ammonium ferrous sulfate	97-100	fibroblast growth factor 21	Mus musculus	79-84
30157856-9	2018	CONCLUSION: FGF21 protects against apoptosis in HUVECs by suppressing the expression of Fas; furthermore, FGF21 alleviated atherosclerosis by ameliorating Fas-mediated apoptosis in apoE-/- mice.	ammonium ferrous sulfate	88-91	fibroblast growth factor 21	Mus musculus	12-17
29864937-2	2018	Fibroblast growth factor 21 (FGF21) is a promising pleiotropic regulator in glucolipid metabolism.	glucolipid	76-86	fibroblast growth factor 21	Mus musculus	29-34
29864937-6	2018	Bleomycin-instilled mice were administered with pirfenidone (PFD) or FGF21 daily for 3 weeks from 7 days after instillation of BLM.	Bleomycin	0-9	fibroblast growth factor 21	Mus musculus	69-74
29864937-8	2018	At the same time, FGF21 also markedly reversed the activity of SOD and T-AOC, decreased the enhanced content of MDA and increased the expression of Nrf-2 in the lungs of BLM-treated mice.	Bleomycin	170-173	fibroblast growth factor 21	Mus musculus	18-23
29864937-10	2018	A549 cells were incubated with PQ plus FGF21 or PFD for 48 h. The results showed that FGF21 and PFD reduced the expression of TGF-beta, Col I and alpha-SMA and increased the expression of E-cadherin in PQ-treated A549 cells.	Paraquat	31-33	fibroblast growth factor 21	Mus musculus	86-91
29864937-11	2018	FGF21 also suppressed oxidative stress in PQ-treated A549 cells, as evidenced by a decrease of the MDA level, a reversed activity of antioxidant enzymes and an increased expression of Nrf-2.	Paraquat	42-44	fibroblast growth factor 21	Mus musculus	0-5
29657029-0	2018	The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.	Water	29-34	fibroblast growth factor 21	Mus musculus	12-17
29751292-0	2018	Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.	Fatty Acids	77-87	fibroblast growth factor 21	Mus musculus	64-69
29753678-11	2018	The induction of hepatic FGF21 in response to the high fat, high sucrose obesogenic diet may play an important role in limiting progression of liver pathology from NAFL to HCC.	Sucrose	65-72	fibroblast growth factor 21	Mus musculus	25-30
29657029-0	2018	The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.	Alcohols	78-85	fibroblast growth factor 21	Mus musculus	12-17
29657029-4	2018	Pharmacologic administration of FGF21 stimulates water drinking behavior in mice within 2 hr.	Water	49-54	fibroblast growth factor 21	Mus musculus	32-37
29657029-5	2018	Concordantly, mice lacking FGF21 fail to increase water intake in response to either alcohol or a ketogenic diet.	Alcohols	85-92	fibroblast growth factor 21	Mus musculus	27-32
29657029-7	2018	Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.	Alcohols	43-50	fibroblast growth factor 21	Mus musculus	11-16
29657029-7	2018	Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.	Alcohols	43-50	fibroblast growth factor 21	Mus musculus	103-108
29657029-7	2018	Given that FGF21 also is known to suppress alcohol intake in favor of pure water, this work identifies FGF21 as a fundamental neurotropic hormone that governs water balance in response to specific nutrient stresses that can cause dehydration.	Water	75-80	fibroblast growth factor 21	Mus musculus	103-108
29706566-1	2018	Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	0-27
29706566-1	2018	Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity.	Glucose	87-94	fibroblast growth factor 21	Mus musculus	29-34
29550873-7	2018	When the carbohydrate/fat ratio was high (LP/HC), mice developed type 2 diabetes despite the robustly elevated hepatic FGF21 secretion and increased energy expenditure.	Carbohydrates	9-21	fibroblast growth factor 21	Mus musculus	119-124
29659970-0	2018	Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism.	Cholic Acid	0-11	fibroblast growth factor 21	Mus musculus	120-147
29401620-0	2018	FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury.	Cisplatin	20-29	fibroblast growth factor 21	Mus musculus	0-5
29401620-2	2018	Fibroblast growth factor (FGF)21 is an endocrine factor that regulates glucose uptake, metabolism, and energy expenditure.	Glucose	71-78	fibroblast growth factor 21	Mus musculus	26-32
29401620-5	2018	Here, we show that FGF21 was dramatically induced during cisplatin treatment of renal tubular cells in vitro and mouse kidneys in vivo.	Cisplatin	57-66	fibroblast growth factor 21	Mus musculus	19-24
29401620-6	2018	The inductive response was suppressed by pifithrin (a pharmacological inhibitor of P53), suggesting a role of P53 in FGF21 induction.	pifithrin	41-50	fibroblast growth factor 21	Mus musculus	117-122
29401620-7	2018	In cultured renal tubular cells, knockdown of FGF21 aggravated cisplatin-induced apoptosis, whereas supplementation of recombinant FGF21 was protective.	Cisplatin	63-72	fibroblast growth factor 21	Mus musculus	46-51
29401620-8	2018	Consistently, recombinant FGF21 alleviated cisplatin-induced kidney dysfunction, tissue damage, and tubular apoptosis in mice.	Cisplatin	43-52	fibroblast growth factor 21	Mus musculus	26-31
29401620-9	2018	Mechanistically, FGF21 suppressed P53 induction and activation during cisplatin treatment.	Cisplatin	70-79	fibroblast growth factor 21	Mus musculus	17-22
29401620-10	2018	Together, these results indicate that FGF21 is induced during cisplatin nephrotoxicity to protect renal tubules, and recombinant FGF21 may have therapeutic potential.-Li, F., Liu, Z., Tang, C., Cai, J., Dong, Z.	Cisplatin	62-71	fibroblast growth factor 21	Mus musculus	38-43
29401620-11	2018	FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury.	Cisplatin	20-29	fibroblast growth factor 21	Mus musculus	0-5
29519677-7	2018	Furthermore, a high-fat diet induced fatty acid oxidation in the hearts of Fgf21-/- mice accompanied by an increase in cardiac oxidative stress.	Fatty Acids	37-47	fibroblast growth factor 21	Mus musculus	75-80
29519677-8	2018	Oil-red O staining revealed the presence of higher amounts of lipid droplets in the hearts of Fgf21-/- mice fed a high-fat diet relative to wt mice fed this same diet.	Oils	0-3	fibroblast growth factor 21	Mus musculus	94-99
29519677-8	2018	Oil-red O staining revealed the presence of higher amounts of lipid droplets in the hearts of Fgf21-/- mice fed a high-fat diet relative to wt mice fed this same diet.	red o	4-9	fibroblast growth factor 21	Mus musculus	94-99
29738435-5	2018	CREBH, in synergy with peroxisome proliferator-activated receptor α (PPARα), has a crucial role in upregulating Fgf21 expression, which is implicated in metabolic homeostasis including glucose and lipid metabolism.	Adenosine Monophosphate	67-70	fibroblast growth factor 21	Mus musculus	132-137
29738435-5	2018	CREBH, in synergy with peroxisome proliferator-activated receptor α (PPARα), has a crucial role in upregulating Fgf21 expression, which is implicated in metabolic homeostasis including glucose and lipid metabolism.	Adenosine Monophosphate	84-87	fibroblast growth factor 21	Mus musculus	132-137
29738435-5	2018	CREBH, in synergy with peroxisome proliferator-activated receptor α (PPARα), has a crucial role in upregulating Fgf21 expression, which is implicated in metabolic homeostasis including glucose and lipid metabolism.	Glucose	205-212	fibroblast growth factor 21	Mus musculus	132-137
29615519-4	2018	Long-term administration of FGF21 in mice fed a standard chow diet resulted in a 50-60% decrease in bile acid levels in the liver and small intestines and consequently a 60% reduction of bile acid pool size.	Bile Acids and Salts	100-109	fibroblast growth factor 21	Mus musculus	28-33
29615519-4	2018	Long-term administration of FGF21 in mice fed a standard chow diet resulted in a 50-60% decrease in bile acid levels in the liver and small intestines and consequently a 60% reduction of bile acid pool size.	Bile Acids and Salts	187-196	fibroblast growth factor 21	Mus musculus	28-33
29627377-5	2018	In mice, FGF21 reduces alcohol intake, and human Fgf21 variants are enriched among heavy drinkers.	Alcohols	23-30	fibroblast growth factor 21	Mus musculus	9-14
29081505-6	2018	RESULTS: Differentiated HIB1B brown adipocytes treated with serotonin had reduced levels of the thermogenic markers uncoupling protein 1 (UCP1) and fibroblast growth factor 21 (FGF21) and increased levels of UCP2.	Serotonin	60-69	fibroblast growth factor 21	Mus musculus	148-175
29081505-6	2018	RESULTS: Differentiated HIB1B brown adipocytes treated with serotonin had reduced levels of the thermogenic markers uncoupling protein 1 (UCP1) and fibroblast growth factor 21 (FGF21) and increased levels of UCP2.	Serotonin	60-69	fibroblast growth factor 21	Mus musculus	177-182
29659970-9	2018	Conclusions: FGF21 signaling is required for the beneficial effect of CA on hepatic TG accumulation in mice fed an HFD.	Triglycerides	84-86	fibroblast growth factor 21	Mus musculus	13-18
29659970-10	2018	We propose that FGF21 signaling potentiates the ability of CA to decrease the activation of ACC1 and HSL, key enzymes controlling the supply of long-chain fatty acid precursors for hepatic TG synthesis.	long-chain fatty acid	144-165	fibroblast growth factor 21	Mus musculus	16-21
29462809-3	2018	In this paper, we studied the effect of FGF-21 on glucose metabolism in the liver.	Glucose	50-57	fibroblast growth factor 21	Mus musculus	40-46
29215172-8	2018	Administration of FGF21 lowered serum insulin and cholesterol (P <= 0.05) and tended to lower free fatty acids (P = 0.057).	Cholesterol	50-61	fibroblast growth factor 21	Mus musculus	18-23
29215172-8	2018	Administration of FGF21 lowered serum insulin and cholesterol (P <= 0.05) and tended to lower free fatty acids (P = 0.057).	Fatty Acids, Nonesterified	97-113	fibroblast growth factor 21	Mus musculus	18-23
29215172-10	2018	FGF21 also increased hepatic incomplete FAO by 12% in both groups and extramitochondrial FAO by 89 and 56% in WT and LPGC-1alpha mice, respectfully (P = 0.001), and lowered hepatic triacylglycerol by 30-40% (P < 0.001).	Triglycerides	181-196	fibroblast growth factor 21	Mus musculus	0-5
29414665-2	2018	Fibroblast growth factor 21 (FGF-21) is a novel metabolic regulator and can function as an endocrine hormone to regulate glucose and lipid metabolism.	Glucose	121-128	fibroblast growth factor 21	Mus musculus	0-27
29414665-2	2018	Fibroblast growth factor 21 (FGF-21) is a novel metabolic regulator and can function as an endocrine hormone to regulate glucose and lipid metabolism.	Glucose	121-128	fibroblast growth factor 21	Mus musculus	29-35
29414665-8	2018	Furthermore, FGF-21 ameliorated glucose uptake of TNF-alpha-induced IR in 3T3-L1 adipocytes by inhibiting NF-kappaB signaling pathway.	Glucose	32-39	fibroblast growth factor 21	Mus musculus	13-19
29444136-9	2018	These results suggest that FGF21 reduces production of alpha-SMA by inhibiting the succinate-GPR91 pathway.	Succinic Acid	83-92	fibroblast growth factor 21	Mus musculus	27-32
29444136-10	2018	We conclude that FGF21 acts as an inhibitor of the succinate-GPR91 pathway to control liver fibrosis.	Succinic Acid	51-60	fibroblast growth factor 21	Mus musculus	17-22
29247651-0	2018	Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77.	Berberine	0-9	fibroblast growth factor 21	Mus musculus	55-60
29247651-4	2018	Here we investigated the effect of berberine on FGF21 expression in primary mouse hepatocytes.	Berberine	35-44	fibroblast growth factor 21	Mus musculus	48-53
29247651-5	2018	As expected, berberine induced hepatic FGF21 expression in a dose-dependent and time-dependent manner, along with the increased expression of NUR77, a proved transcription factor of FGF21.	Berberine	13-22	fibroblast growth factor 21	Mus musculus	39-44
29247651-5	2018	As expected, berberine induced hepatic FGF21 expression in a dose-dependent and time-dependent manner, along with the increased expression of NUR77, a proved transcription factor of FGF21.	Berberine	13-22	fibroblast growth factor 21	Mus musculus	182-187
29247651-8	2018	The inhibition of AMPK by compound C abolished berberine-stimulated FGF21 and NUR77 expressions.	Berberine	47-56	fibroblast growth factor 21	Mus musculus	68-73
29247651-9	2018	These results suggest that berberine-induced activation of AMPK may contribute to hepatic FGF21 expression via NUR77.	Berberine	27-36	fibroblast growth factor 21	Mus musculus	90-95
29448103-0	2018	FGF 21 deficiency slows gastric emptying and reduces initial blood alcohol concentration in mice exposed to acute alcohol in fasting state.	Alcohols	67-74	fibroblast growth factor 21	Mus musculus	0-6
29448103-0	2018	FGF 21 deficiency slows gastric emptying and reduces initial blood alcohol concentration in mice exposed to acute alcohol in fasting state.	Alcohols	114-121	fibroblast growth factor 21	Mus musculus	0-6
29448103-3	2018	Previous study demonstrated that FGF21 deficiency exacerbated alcohol-induced liver injury and exogenous FGF21 administration protected liver from chronic alcohol-induced injury.	Alcohols	62-69	fibroblast growth factor 21	Mus musculus	33-38
29448103-3	2018	Previous study demonstrated that FGF21 deficiency exacerbated alcohol-induced liver injury and exogenous FGF21 administration protected liver from chronic alcohol-induced injury.	Alcohols	155-162	fibroblast growth factor 21	Mus musculus	105-110
29448103-4	2018	In this study, we aimed to explore the role of FGF21 in alcohol metabolism in mice.	Alcohols	56-63	fibroblast growth factor 21	Mus musculus	47-52
29445083-3	2018	High-fat-diet/streptozotocin-induced type 2 diabetes was established in both wild-type (WT) and FGF21-knockout (FGF21-KO) mice followed by treating with FGF21 for 4 months.	Streptozocin	14-28	fibroblast growth factor 21	Mus musculus	96-101
29445083-3	2018	High-fat-diet/streptozotocin-induced type 2 diabetes was established in both wild-type (WT) and FGF21-knockout (FGF21-KO) mice followed by treating with FGF21 for 4 months.	Streptozocin	14-28	fibroblast growth factor 21	Mus musculus	112-117
29445083-3	2018	High-fat-diet/streptozotocin-induced type 2 diabetes was established in both wild-type (WT) and FGF21-knockout (FGF21-KO) mice followed by treating with FGF21 for 4 months.	Streptozocin	14-28	fibroblast growth factor 21	Mus musculus	112-117
29445083-11	2018	And, inhibition of fatty acid beta-oxidation partially blocked FGF21-induced protection in cardiomyocytes.	Fatty Acids	19-29	fibroblast growth factor 21	Mus musculus	63-68
29198028-10	2018	Further, immunoblot data showed that hepatocellular fibroblast growth factor 21 (FGF21) in PFOA-exposed liver was down-regulated dose-dependently.	perfluorooctanoic acid	91-95	fibroblast growth factor 21	Mus musculus	52-79
29198028-10	2018	Further, immunoblot data showed that hepatocellular fibroblast growth factor 21 (FGF21) in PFOA-exposed liver was down-regulated dose-dependently.	perfluorooctanoic acid	91-95	fibroblast growth factor 21	Mus musculus	81-86
29371695-0	2018	Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.	Metformin	0-9	fibroblast growth factor 21	Mus musculus	87-92
29371695-8	2018	In addition, metformin increased the production of pAMPK and FGF21.	Metformin	13-22	fibroblast growth factor 21	Mus musculus	61-66
29065221-0	2018	Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21.	Berberine	0-9	fibroblast growth factor 21	Mus musculus	105-132
29065221-7	2018	KEY RESULTS: Berberine attenuated hepatic steatosis and controlled energy balance in mice by inducing autophagy and FGF21.	Berberine	13-22	fibroblast growth factor 21	Mus musculus	116-121
29065221-11	2018	Moreover, the administration of berberine was shown to promote hepatic gene expression and circulating levels of FGF21 and ketone bodies in mice in a SIRT1-dependent manner.	Berberine	32-41	fibroblast growth factor 21	Mus musculus	113-118
29065221-12	2018	CONCLUSIONS AND IMPLICATIONS: Berberine acts in the liver to regulate lipid utilization and maintain whole-body energy metabolism by mediating autophagy and FGF21 activation.	Berberine	30-39	fibroblast growth factor 21	Mus musculus	157-162
29462809-9	2018	RESULTS: In this study, FGF-21 stimulated glucose uptake by liver cells in both a dose and time-dependent manner, and at the same time, FGF-21 specifically stimulated GLUT1 expression in the liver cells.	Glucose	42-49	fibroblast growth factor 21	Mus musculus	24-30
29462809-10	2018	Furthermore, FGF-21 demonstrated a synergistic effect with insulin on glucose absorption, which is in accordance with enhanced GLUT-1 and -4 expression.	Glucose	70-77	fibroblast growth factor 21	Mus musculus	13-19
29462809-11	2018	Treatment with FGF-21 increased glycogen storage in liver cells.	Glycogen	32-40	fibroblast growth factor 21	Mus musculus	15-21
29462809-12	2018	Consistent with in vitro results, FGF-21 lowered the plasma glucose level and stimulated GLUT1 expression and glycogen synthesis in db/db diabetic mice.	Glucose	60-67	fibroblast growth factor 21	Mus musculus	34-40
29462809-12	2018	Consistent with in vitro results, FGF-21 lowered the plasma glucose level and stimulated GLUT1 expression and glycogen synthesis in db/db diabetic mice.	Glycogen	110-118	fibroblast growth factor 21	Mus musculus	34-40
29462809-14	2018	CONCLUSION: Our results suggest that FGF-21 clears up plasma glucose by stimulating glucose absorption in the liver of diabetic animals and decreases glucose release from the liver by inhibiting gluconeogenesis.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	37-43
29462809-14	2018	CONCLUSION: Our results suggest that FGF-21 clears up plasma glucose by stimulating glucose absorption in the liver of diabetic animals and decreases glucose release from the liver by inhibiting gluconeogenesis.	Glucose	84-91	fibroblast growth factor 21	Mus musculus	37-43
29462809-14	2018	CONCLUSION: Our results suggest that FGF-21 clears up plasma glucose by stimulating glucose absorption in the liver of diabetic animals and decreases glucose release from the liver by inhibiting gluconeogenesis.	Glucose	84-91	fibroblast growth factor 21	Mus musculus	37-43
29462809-15	2018	Overall, these data indicate that the liver is an important target organ of FGF-21 to regulate glucose metabolism.	Glucose	95-102	fibroblast growth factor 21	Mus musculus	76-82
29107287-0	2017	Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.	Ethanol	59-66	fibroblast growth factor 21	Mus musculus	0-27
29375676-8	2018	In addition, FGF21 inhibition in DCM mice elevated the quantity of lipid droplets and the concentration of heart triglycerides, plasma triglycerides and cholesterol levels, accompanied by downregulation of peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and upregulation of cluster of differentiation (CD)36.	Triglycerides	113-126	fibroblast growth factor 21	Mus musculus	13-18
29375676-8	2018	In addition, FGF21 inhibition in DCM mice elevated the quantity of lipid droplets and the concentration of heart triglycerides, plasma triglycerides and cholesterol levels, accompanied by downregulation of peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and upregulation of cluster of differentiation (CD)36.	Triglycerides	135-148	fibroblast growth factor 21	Mus musculus	13-18
29375676-8	2018	In addition, FGF21 inhibition in DCM mice elevated the quantity of lipid droplets and the concentration of heart triglycerides, plasma triglycerides and cholesterol levels, accompanied by downregulation of peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and upregulation of cluster of differentiation (CD)36.	Cholesterol	153-164	fibroblast growth factor 21	Mus musculus	13-18
28886439-6	2017	Plasma FGF21 levels were highest among the three groups in mice fed a high-sucrose diet, whereas no significant difference in GLP-1 levels was observed.	Sucrose	75-82	fibroblast growth factor 21	Mus musculus	7-12
28886439-7	2017	Expression levels of uncoupling protein 1 (UCP-1), FGF receptor 1c (FGFR1c) and beta-klotho (KLB) mRNA in brown adipose tissue were significantly increased in high sucrose-fed mice, suggesting increases in FGF21 sensitivity and energy expenditure.	Sucrose	164-171	fibroblast growth factor 21	Mus musculus	206-211
28886439-9	2017	These results indicate that FGF21 production in liver and brown adipose tissue is increased in high-sucrose diet and participates in resistance to weight gain.	Sucrose	100-107	fibroblast growth factor 21	Mus musculus	28-33
29962431-1	2018	Fibroblast growth factor 21 (FGF21), mainly synthesized and secreted from the liver, is an endocrine FGF that regulates glucose and fatty acid metabolism to maintain whole body energy homeostasis.	Glucose	120-127	fibroblast growth factor 21	Mus musculus	0-27
29962431-1	2018	Fibroblast growth factor 21 (FGF21), mainly synthesized and secreted from the liver, is an endocrine FGF that regulates glucose and fatty acid metabolism to maintain whole body energy homeostasis.	Glucose	120-127	fibroblast growth factor 21	Mus musculus	29-34
29962431-1	2018	Fibroblast growth factor 21 (FGF21), mainly synthesized and secreted from the liver, is an endocrine FGF that regulates glucose and fatty acid metabolism to maintain whole body energy homeostasis.	Fatty Acids	132-142	fibroblast growth factor 21	Mus musculus	0-27
29962431-1	2018	Fibroblast growth factor 21 (FGF21), mainly synthesized and secreted from the liver, is an endocrine FGF that regulates glucose and fatty acid metabolism to maintain whole body energy homeostasis.	Fatty Acids	132-142	fibroblast growth factor 21	Mus musculus	29-34
29962431-6	2018	In mice, postprandial and tunicamycin-induced ER stress was significantly reduced by overexpression of FGF21 using a recombinant adenovirus.	Tunicamycin	26-37	fibroblast growth factor 21	Mus musculus	103-108
28472473-9	2017	Furthermore, the hearts of Fgf21-/- mice exhibited reductions in their fatty acid oxidation levels, which may compromise cardiac function during pregnancy.	Fatty Acids	71-81	fibroblast growth factor 21	Mus musculus	27-32
28770320-5	2017	RESULTS: FGF21 treatment prevented islet destruction and the onset of hyperglycaemia, and improved glucose clearance.	Glucose	99-106	fibroblast growth factor 21	Mus musculus	9-14
28886439-0	2017	Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice.	Sucrose	13-20	fibroblast growth factor 21	Mus musculus	36-63
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Fructose	43-51	fibroblast growth factor 21	Mus musculus	217-244
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Fructose	43-51	fibroblast growth factor 21	Mus musculus	246-251
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Glucose	53-60	fibroblast growth factor 21	Mus musculus	217-244
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Glucose	53-60	fibroblast growth factor 21	Mus musculus	246-251
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Sucrose	64-71	fibroblast growth factor 21	Mus musculus	217-244
28886439-2	2017	On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight.	Sucrose	64-71	fibroblast growth factor 21	Mus musculus	246-251
29107287-0	2017	Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.	Ethanol	59-66	fibroblast growth factor 21	Mus musculus	29-34
29107287-0	2017	Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.	Ethanol	96-103	fibroblast growth factor 21	Mus musculus	0-27
29107287-0	2017	Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.	Ethanol	96-103	fibroblast growth factor 21	Mus musculus	29-34
29107287-12	2017	When FGF21-KO mice were fed the Lieber-DeCarli diet, a high fat diet supplemented with ethanol, a higher mortality was observed compared to WT mice after 16 days on the diet.	Ethanol	87-94	fibroblast growth factor 21	Mus musculus	5-10
29107287-13	2017	When FGF21-KO mice consumed 30% ethanol in drinking water, along with a normal chow diet, there was no mortality observed even after 16 weeks, but the FGF21-KO mice had significant liver pathology compared to WT mice.	Ethanol	32-39	fibroblast growth factor 21	Mus musculus	5-13
29107287-13	2017	When FGF21-KO mice consumed 30% ethanol in drinking water, along with a normal chow diet, there was no mortality observed even after 16 weeks, but the FGF21-KO mice had significant liver pathology compared to WT mice.	Water	52-57	fibroblast growth factor 21	Mus musculus	5-13
29107287-17	2017	This suggests that FGF21 protects against long term ethanol induced hepatic damage and may attenuate progression of alcoholic liver disease.	Ethanol	52-59	fibroblast growth factor 21	Mus musculus	19-24
29020627-0	2017	A Specific ChREBP and PPARalpha Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.	Glucose	63-70	fibroblast growth factor 21	Mus musculus	80-85
29020627-5	2017	Unexpectedly, carbohydrate challenge of hepatic Pparalpha knockout mice also demonstrated a PPARalpha-dependent glucose response for Fgf21 that was associated with an increased sucrose preference.	Glucose	112-119	fibroblast growth factor 21	Mus musculus	133-138
29020627-2	2017	We report that peroxisome-proliferator-activated receptor alpha (PPARalpha), a nuclear receptor of the fasting response, is required with the carbohydrate-sensitive transcription factor carbohydrate-responsive element-binding protein (ChREBP) to balance FGF21 glucose response.	Glucose	260-267	fibroblast growth factor 21	Mus musculus	254-259
29020627-5	2017	Unexpectedly, carbohydrate challenge of hepatic Pparalpha knockout mice also demonstrated a PPARalpha-dependent glucose response for Fgf21 that was associated with an increased sucrose preference.	Sucrose	177-184	fibroblast growth factor 21	Mus musculus	133-138
29020627-4	2017	Glucose-challenged Chrebp-/- mice exhibit a marked reduction in FGF21 production, a decrease that was rescued by re-expression of an active ChREBP isoform in the liver of Chrebp-/- mice.	Glucose	0-7	fibroblast growth factor 21	Mus musculus	64-69
29020627-6	2017	This blunted response was due to decreased Fgf21 promoter accessibility and diminished ChREBP binding onto Fgf21 carbohydrate-responsive element (ChoRE) in hepatocytes lacking PPARalpha.	Carbohydrates	113-125	fibroblast growth factor 21	Mus musculus	107-112
29020627-7	2017	Our study reports that PPARalpha is required for the ChREBP-induced glucose response of FGF21.	Glucose	68-75	fibroblast growth factor 21	Mus musculus	88-93
29020627-5	2017	Unexpectedly, carbohydrate challenge of hepatic Pparalpha knockout mice also demonstrated a PPARalpha-dependent glucose response for Fgf21 that was associated with an increased sucrose preference.	Carbohydrates	14-26	fibroblast growth factor 21	Mus musculus	133-138
28404815-8	2017	In WAT of WT mice, but not of FGF21-deficient mice, fenofibrate enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte dysfunctions in WAT in high-fat-diet-fed WT mice but not in FGF21-deficient mice.	Fenofibrate	52-63	fibroblast growth factor 21	Mus musculus	336-341
28938407-4	2017	This review summarizes what is known about FGF21 in mice and humans with a special focus on this factor"s role in glucose and lipid metabolism and in metabolic diseases, such as obesity and type 2 diabetes mellitus.	Glucose	114-121	fibroblast growth factor 21	Mus musculus	43-48
28938440-1	2017	Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity.	Carbohydrates	35-47	fibroblast growth factor 21	Mus musculus	96-123
28938440-1	2017	Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity.	Carbohydrates	35-47	fibroblast growth factor 21	Mus musculus	125-130
28747486-6	2017	These changes were associated with a 650% higher secretion of fibroblast growth factor 21 (FGF21) 2 h after refeeding.Conclusions: The consequences of hepatic AMPK deletion depend on the dietary carbohydrate-to-protein ratio.	Carbohydrates	195-207	fibroblast growth factor 21	Mus musculus	62-89
28747486-6	2017	These changes were associated with a 650% higher secretion of fibroblast growth factor 21 (FGF21) 2 h after refeeding.Conclusions: The consequences of hepatic AMPK deletion depend on the dietary carbohydrate-to-protein ratio.	Carbohydrates	195-207	fibroblast growth factor 21	Mus musculus	91-96
28837153-0	2017	Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway.	Doxorubicin	64-75	fibroblast growth factor 21	Mus musculus	28-55
28837153-2	2017	Fibroblast growth factor 21 (FGF21), as a well-known regulator of glucose and lipid metabolism, was recently shown to exert cardioprotective effects.	Glucose	66-73	fibroblast growth factor 21	Mus musculus	0-27
28837153-2	2017	Fibroblast growth factor 21 (FGF21), as a well-known regulator of glucose and lipid metabolism, was recently shown to exert cardioprotective effects.	Glucose	66-73	fibroblast growth factor 21	Mus musculus	29-34
28837153-3	2017	The aim of this study was to investigate the possible protective effects of FGF21 against DOX-induced cardiomyopathy.	Doxorubicin	90-93	fibroblast growth factor 21	Mus musculus	76-81
28837153-5	2017	Treatment with FGF21 obviously attenuated the DOX-induced cardiac dysfunction and pathological changes.	Doxorubicin	46-49	fibroblast growth factor 21	Mus musculus	15-20
28837153-7	2017	The anti-oxidative stress activity of FGF21 was achieved via reduced generation of reactive oxygen species through regulation of nuclear transcription factor erythroid 2-related factor 2 transcription.	Reactive Oxygen Species	83-106	fibroblast growth factor 21	Mus musculus	38-43
28837153-11	2017	The present work demonstrates for the first time that FGF21 obviously prevented DOX-induced cardiotoxicity via the suppression of oxidative stress, inflammation, and apoptosis through the SIRT1/LKB1/AMPK signaling pathway.	Doxorubicin	80-83	fibroblast growth factor 21	Mus musculus	54-59
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	atg7h	32-37	fibroblast growth factor 21	Mus musculus	139-166
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	atg7h	32-37	fibroblast growth factor 21	Mus musculus	168-173
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	atg7h	32-37	fibroblast growth factor 21	Mus musculus	185-190
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	atg7h	32-37	fibroblast growth factor 21	Mus musculus	249-254
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	Adenosine Monophosphate	38-41	fibroblast growth factor 21	Mus musculus	139-166
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	Adenosine Monophosphate	38-41	fibroblast growth factor 21	Mus musculus	185-190
28801668-6	2017	Interestingly, exercise-trained Atg7h&mKO mice were better protected against obesity and insulin resistance with increased circulating fibroblast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation of FGF21-target genes involved in thermogenesis and fatty acid oxidation in brown fat.	Adenosine Monophosphate	38-41	fibroblast growth factor 21	Mus musculus	249-254
28591702-7	2017	Endogenous FGF21 concentrations in APAP-treated mice were decreased in sera and liver cells.	Acetaminophen	35-39	fibroblast growth factor 21	Mus musculus	11-16
28457799-6	2017	A high dietary protein:CHO ratio reduced plasma FGF21 concentration, and increased liver PCK1 protein content and plasma triglyceride concentration.	CAV protocol	23-26	fibroblast growth factor 21	Mus musculus	48-53
28938407-1	2017	Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very robust data documenting this factor"s favorable effects on glucose and lipid metabolism in mice.	Glucose	244-251	fibroblast growth factor 21	Mus musculus	79-112
27925195-7	2017	Regarding AMPK downstream, palmitoleic acid increased the production of FGF-21 and stimulated the expression of PPARalpha.	palmitoleic acid	27-43	fibroblast growth factor 21	Mus musculus	72-78
27925195-9	2017	CONCLUSIONS: In mice fed with a high-fat diet, palmitoleic acid supplementation stimulated the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARalpha.	palmitoleic acid	47-63	fibroblast growth factor 21	Mus musculus	153-159
27925195-9	2017	CONCLUSIONS: In mice fed with a high-fat diet, palmitoleic acid supplementation stimulated the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARalpha.	Glucose	105-112	fibroblast growth factor 21	Mus musculus	153-159
28559425-3	2017	Primary cultured cardiomyocytes were also used to explore the potential molecular mechanism of FGF21 in the protection of high glucose (HG)-induced cardiomyocyte injury.	Glucose	127-134	fibroblast growth factor 21	Mus musculus	95-100
28559425-4	2017	STZ/HFD-induced cardiomyopathy was exacerbated in FGF21 knockout mice, which was accompanied by a significant reduction in cardiac AMP-activated protein kinase (AMPK) activity and paraoxonase 1 (PON1) expression.	Streptozocin	0-3	fibroblast growth factor 21	Mus musculus	50-55
28559425-5	2017	By contrast, adeno-associated virus (AAV)-mediated overexpression of FGF21 in STZ/HFD-induced diabetic mice significantly enhanced cardiac AMPK activity, PON1 expression and its biological activity, resulting in alleviated DCM.	Streptozocin	78-81	fibroblast growth factor 21	Mus musculus	69-74
28404815-9	2017	These findings indicate that FGF21 is crucial for the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.	Fenofibrate	54-65	fibroblast growth factor 21	Mus musculus	29-34
28404815-9	2017	These findings indicate that FGF21 is crucial for the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.	Glucose	101-108	fibroblast growth factor 21	Mus musculus	29-34
28575427-0	2017	Corrigendum for "Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Fed Male Mice".	Polyphenols	22-32	fibroblast growth factor 21	Mus musculus	61-66
28477305-11	2017	Obestatin influenced the expression of genes involved in lipid and carbohydrate metabolism by increasing Fabp5 and decreasing G6pc, Pepck, Fgf21 mRNA in the liver.	Ghrelin	0-9	fibroblast growth factor 21	Mus musculus	139-144
28374748-5	2017	FGF21 induces mobilization of calcium from the endoplasmic reticulum, which activates the transcriptional repressor downstream regulatory element antagonist modulator (DREAM), and thereby inhibits expression of Mid1 (encoding the E3 ligase Midline-1).	Calcium	30-37	fibroblast growth factor 21	Mus musculus	0-5
28575427-0	2017	Corrigendum for "Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Fed Male Mice".	Curcumin	33-41	fibroblast growth factor 21	Mus musculus	61-66
28579299-6	2017	Moreover, empagliflozin shifted energy metabolism towards fat utilization, elevated AMP-activated protein kinase and acetyl-CoA carbolxylase phosphorylation in skeletal muscle, and increased hepatic and plasma fibroblast growth factor 21 levels.	empagliflozin	10-23	fibroblast growth factor 21	Mus musculus	210-237
28520765-2	2017	Hepatic sensing of reduced methionine leads to induction and release of fibroblast growth factor 21 (FGF21), which acts centrally to increase sympathetic tone and activate thermogenesis in adipose tissue.	Methionine	27-37	fibroblast growth factor 21	Mus musculus	72-99
28520765-2	2017	Hepatic sensing of reduced methionine leads to induction and release of fibroblast growth factor 21 (FGF21), which acts centrally to increase sympathetic tone and activate thermogenesis in adipose tissue.	Methionine	27-37	fibroblast growth factor 21	Mus musculus	101-106
28520765-3	2017	FGF21 also has direct effects in adipose to enhance glucose uptake and oxidation.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	0-5
27917437-9	2017	Furthermore, nicotine treatment significantly (P < 0.05) attenuated the HFD-induced decrease in fibroblast growth factor 21 (FGF21) and silent information regulator 1 (SIRT1).	Nicotine	13-21	fibroblast growth factor 21	Mus musculus	99-126
28467924-2	2017	The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice.	Sugars	138-143	fibroblast growth factor 21	Mus musculus	122-127
28374855-0	2017	Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states.	Glucose	50-57	fibroblast growth factor 21	Mus musculus	0-27
28374855-7	2017	FGF21 at elevated glucose increased [Ca2+]i in PVN NUCB2/Nesf-1 neurons.	Glucose	18-25	fibroblast growth factor 21	Mus musculus	0-5
28374855-9	2017	These findings reveal that FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism.	Glucose	55-62	fibroblast growth factor 21	Mus musculus	27-32
28374855-9	2017	These findings reveal that FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism.	Glucose	253-260	fibroblast growth factor 21	Mus musculus	27-32
28324011-1	2017	Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism.	Glucose	70-77	fibroblast growth factor 21	Mus musculus	0-33
28422755-2	2017	Klb-/- mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis.	Glucose	108-115	fibroblast growth factor 21	Mus musculus	67-72
28580278-3	2017	This work examined the role of AMPK in mediating the glucose and lipid-lowering effects of FGF21.	Glucose	53-60	fibroblast growth factor 21	Mus musculus	91-96
28580278-9	2017	Lastly, we assessed whether FGF21 exerted its effects through the AMPK/ACC axis, which is critical in the therapeutic benefits of the anti-diabetic medication metformin.	Metformin	159-168	fibroblast growth factor 21	Mus musculus	28-33
27917437-9	2017	Furthermore, nicotine treatment significantly (P < 0.05) attenuated the HFD-induced decrease in fibroblast growth factor 21 (FGF21) and silent information regulator 1 (SIRT1).	Nicotine	13-21	fibroblast growth factor 21	Mus musculus	128-133
27917437-10	2017	We conclude that nicotine, when combined with HFD, triggers CM apoptosis through the generation of oxidative stress and inactivation of AMPK together with the activation of caspase-2-mediated intrinsic apoptotic signaling independently of FGF21 and SIRT1.	Nicotine	17-25	fibroblast growth factor 21	Mus musculus	239-244
28143735-1	2017	Fibroblast growth factor 21 (FGF21) is a promising regulator of glucose and lipid metabolism with multiple beneficial effects including hypoglycemic and lipid-lowering.	Glucose	64-71	fibroblast growth factor 21	Mus musculus	0-27
28337713-7	2017	Chronic treatment with recombinant FGF21 reduces serum and hepatic triglyceride levels and ameliorates fatty liver in obese mice, through the suppression of the lipogenic gene, Srebp-1.	Triglycerides	67-79	fibroblast growth factor 21	Mus musculus	35-40
28096260-0	2017	FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism.	Methionine	74-84	fibroblast growth factor 21	Mus musculus	0-5
28143735-1	2017	Fibroblast growth factor 21 (FGF21) is a promising regulator of glucose and lipid metabolism with multiple beneficial effects including hypoglycemic and lipid-lowering.	Glucose	64-71	fibroblast growth factor 21	Mus musculus	29-34
28143735-10	2017	Compared with liraglutide and insulin glargine, mFGF21 significantly reduced the glycosylated hemoglobin levels and improved the ability on glycemic control, insulin resistance, serum lipid and liver function states in db/db mice after 8weeks treatments.	Insulin Glargine	38-46	fibroblast growth factor 21	Mus musculus	48-54
28143735-11	2017	In addition, mFGF21 regulated glucose metabolism through increasing the mRNA expression levels of GK and GLUT-1, and decreasing the mRNA expression level of G6P.	Glucose	30-37	fibroblast growth factor 21	Mus musculus	13-19
28256636-0	2017	Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.	Retinoids	111-119	fibroblast growth factor 21	Mus musculus	9-36
28315901-8	2017	Sitagliptin treatment depressed blood lipid levels, increased serum FGF-21 and FGF-19 levels, PPAR-alpha, CREBH, and CPT1 expression, and suppressed FAS expression (p<0.05).	Sitagliptin Phosphate	0-11	fibroblast growth factor 21	Mus musculus	68-74
28315901-9	2017	CONCLUSIONS Sitagliptin can protect liver tissue and modulate lipid metabolism in NAFLD mice via elevating FGF-21 and FGF-19, upregulating liver PPAR-a and CREBH levels, and mediating expression levels of key enzymes for lipid metabolism.	Sitagliptin Phosphate	12-23	fibroblast growth factor 21	Mus musculus	107-113
28131861-9	2017	Basal levels of serum FGF21 were lower in Pparalpha-/- mice than in Pparalpha+/+ mice; ethanol induced FGF21 in Pparalpha+/+ mice but not in Pparalpha-/- mice, whereas ethanol induced hypertriglyceridemia in Pparalpha-/- mice but not in Pparalpha+/+ mice.	Ethanol	87-94	fibroblast growth factor 21	Mus musculus	103-108
28131861-10	2017	Administration of recombinant FGF21 normalized serum FGF21 and triglyceride in Pparalpha-/- mice.	Triglycerides	63-75	fibroblast growth factor 21	Mus musculus	30-35
28256636-0	2017	Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.	Retinoids	111-119	fibroblast growth factor 21	Mus musculus	38-43
28256636-0	2017	Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.	Fenretinide	120-131	fibroblast growth factor 21	Mus musculus	9-36
28256636-0	2017	Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.	Fenretinide	120-131	fibroblast growth factor 21	Mus musculus	38-43
28256636-5	2017	Fenretinide normalised elevated levels of FGF21 in both high-fat diet-induced obese mice and in genetically obese-diabetic Leprdbmice.	Fenretinide	0-11	fibroblast growth factor 21	Mus musculus	42-47
28256636-6	2017	Moreover, Fenretinide-mediated suppression of FGF21 was independent of body weight loss or improved hepatic insulin sensitivity and importantly does not induce unhealthy metabolic complications.	Fenretinide	10-21	fibroblast growth factor 21	Mus musculus	46-51
28256636-7	2017	In mice which have substantially decreased endogenous retinoic acid biosynthesis, Fgf21 expression was increased, whereas acute pharmacological retinoid treatment decreased FGF21 levels.	Tretinoin	54-67	fibroblast growth factor 21	Mus musculus	82-87
28256636-7	2017	In mice which have substantially decreased endogenous retinoic acid biosynthesis, Fgf21 expression was increased, whereas acute pharmacological retinoid treatment decreased FGF21 levels.	Retinoids	144-152	fibroblast growth factor 21	Mus musculus	173-178
28256636-8	2017	The repression of FGF21 levels by Fenretinide occurs by reduced binding of RARalpha and Pol-II at the Fgf21 promoter.	Fenretinide	34-45	fibroblast growth factor 21	Mus musculus	18-23
28256636-8	2017	The repression of FGF21 levels by Fenretinide occurs by reduced binding of RARalpha and Pol-II at the Fgf21 promoter.	Fenretinide	34-45	fibroblast growth factor 21	Mus musculus	102-107
28256636-9	2017	We therefore establish Fgf21 as a novel gene target of Fenretinide signalling via a retinoid-dependent mechanism.	Fenretinide	55-66	fibroblast growth factor 21	Mus musculus	23-28
28256636-9	2017	We therefore establish Fgf21 as a novel gene target of Fenretinide signalling via a retinoid-dependent mechanism.	Retinoids	84-92	fibroblast growth factor 21	Mus musculus	23-28
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	0-33
28088388-10	2017	In conclusion, via GR activation, DEX induced Fgf21 expression in mouse liver and human hepatoma cells.	Dexamethasone	34-37	fibroblast growth factor 21	Mus musculus	46-51
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Dioxins	183-190	fibroblast growth factor 21	Mus musculus	0-33
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Acetaminophen	192-205	fibroblast growth factor 21	Mus musculus	0-33
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Acetaminophen	207-211	fibroblast growth factor 21	Mus musculus	0-33
28088388-2	2017	Fibroblast growth factor (Fgf) 21, an important regulator of glucose, lipid, and energy metabolism, plays a cytoprotective role by attenuating toxicities induced by chemicals such as dioxins, acetaminophen (APAP), and alcohols.	Alcohols	218-226	fibroblast growth factor 21	Mus musculus	0-33
28088388-3	2017	The present study investigates the impact of dexamethasone (DEX)-activated GR on Fgf21 expression and how it affects the progression of APAP-induced hepatotoxicity.	Dexamethasone	45-58	fibroblast growth factor 21	Mus musculus	81-86
28088388-3	2017	The present study investigates the impact of dexamethasone (DEX)-activated GR on Fgf21 expression and how it affects the progression of APAP-induced hepatotoxicity.	Dexamethasone	60-63	fibroblast growth factor 21	Mus musculus	81-86
28088388-4	2017	Our results showed that DEX dose/concentration- and time-dependently increased Fgf21 mRNA and protein expression in mouse liver as well as cultured mouse and human hepatoma cells.	Dexamethasone	24-27	fibroblast growth factor 21	Mus musculus	79-84
28088388-5	2017	By using PXR-null mouse model, we demonstrated that DEX induced Fgf21 expression by a PXR-independent mechanism.	Dexamethasone	52-55	fibroblast growth factor 21	Mus musculus	64-69
27967217-0	2017	Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.	Polyphenols	5-15	fibroblast growth factor 21	Mus musculus	44-49
28089565-6	2017	Like the classical post-prandial secretagogue, cholecystokinin (CCK), FGF21 triggers intracellular calcium release via PLC-IP3R signaling.	Calcium	99-106	fibroblast growth factor 21	Mus musculus	70-75
28089565-6	2017	Like the classical post-prandial secretagogue, cholecystokinin (CCK), FGF21 triggers intracellular calcium release via PLC-IP3R signaling.	plc-ip3r	119-127	fibroblast growth factor 21	Mus musculus	70-75
27967217-0	2017	Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.	Curcumin	16-24	fibroblast growth factor 21	Mus musculus	44-49
28041926-0	2017	Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action.	Bile Acids and Salts	65-74	fibroblast growth factor 21	Mus musculus	27-54
27967217-1	2017	We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression.	Curcumin	36-44	fibroblast growth factor 21	Mus musculus	77-104
28041926-2	2017	However, a role for FGF21 in the regulation of bile acid metabolism has not been reported.	Bile Acids and Salts	47-56	fibroblast growth factor 21	Mus musculus	20-25
27967217-1	2017	We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression.	Curcumin	36-44	fibroblast growth factor 21	Mus musculus	106-111
28041926-3	2017	Herein, we demonstrate AAV-mediated FGF21 overexpression in mice increases liver expression of the key bile acid producing enzyme, Cyp7a1, resulting in an increased bile acid pool.	Bile Acids and Salts	103-112	fibroblast growth factor 21	Mus musculus	36-41
27967217-3	2017	Fgf21 stimulation was observed at messenger RNA and protein levels in mice with daily curcumin gavage for 4 or 8 days and in primary hepatocytes with curcumin treatment.	Curcumin	86-94	fibroblast growth factor 21	Mus musculus	0-5
28041926-3	2017	Herein, we demonstrate AAV-mediated FGF21 overexpression in mice increases liver expression of the key bile acid producing enzyme, Cyp7a1, resulting in an increased bile acid pool.	Bile Acids and Salts	165-174	fibroblast growth factor 21	Mus musculus	36-41
27967217-3	2017	Fgf21 stimulation was observed at messenger RNA and protein levels in mice with daily curcumin gavage for 4 or 8 days and in primary hepatocytes with curcumin treatment.	Curcumin	150-158	fibroblast growth factor 21	Mus musculus	0-5
28041926-4	2017	Furthermore, in cholecystectomized mice, FGF21-mediated bile acid pool increase led to increased transit of bile acids into colon.	Bile Acids and Salts	56-65	fibroblast growth factor 21	Mus musculus	41-46
27967217-4	2017	Using peroxisome proliferator-activated receptor alpha (PPARalpha) agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARalpha activation.	Curcumin	188-196	fibroblast growth factor 21	Mus musculus	208-213
28041926-4	2017	Furthermore, in cholecystectomized mice, FGF21-mediated bile acid pool increase led to increased transit of bile acids into colon.	Bile Acids and Salts	108-118	fibroblast growth factor 21	Mus musculus	41-46
28041926-5	2017	We elucidate that the mechanism of FGF21 induced bile acid changes is mainly through antagonizing FGF15/19 function on liver betaKlotho/FGFR4 receptor complex; thus inhibiting FGF15/19-mediated suppression of Cyp7a1 expression.	Bile Acids and Salts	49-58	fibroblast growth factor 21	Mus musculus	35-40
27967217-7	2017	Importantly, hepatocytes from HFD-fed mice showed a loss of response to FGF21 treatment on Erk phosphorylation and the expression of Egr1 and cFos; this response was restored in hepatocytes from HFD-fed mice with curcumin intervention.	Curcumin	213-221	fibroblast growth factor 21	Mus musculus	72-77
28041926-6	2017	In conclusion, these data reveal a previously unidentified role for FGF21 on bile acid metabolism and may be relevant to understand the effects of FGF21 analogs in clinical studies.	Bile Acids and Salts	77-86	fibroblast growth factor 21	Mus musculus	68-73
27967217-8	2017	This investigation expanded our mechanistic understanding of the metabolic beneficial effects of dietary curcumin intervention involving the regulation of Fgf21 production and the attenuation of HFD-induced Fgf21 resistance.	Curcumin	105-113	fibroblast growth factor 21	Mus musculus	155-160
27967217-8	2017	This investigation expanded our mechanistic understanding of the metabolic beneficial effects of dietary curcumin intervention involving the regulation of Fgf21 production and the attenuation of HFD-induced Fgf21 resistance.	Curcumin	105-113	fibroblast growth factor 21	Mus musculus	207-212
28584524-12	2017	Moreover, DSS treatment markedly increased serum IL-6 and FGF21 levels.	Dextran Sulfate	10-13	fibroblast growth factor 21	Mus musculus	58-63
27811171-1	2017	Fibroblast growth factor 21 (FGF21) has recently emerged as a novel endocrine hormone involved in the regulation of glucose and lipid metabolism.	Glucose	116-123	fibroblast growth factor 21	Mus musculus	0-27
27811171-1	2017	Fibroblast growth factor 21 (FGF21) has recently emerged as a novel endocrine hormone involved in the regulation of glucose and lipid metabolism.	Glucose	116-123	fibroblast growth factor 21	Mus musculus	29-34
27811171-4	2017	The administration of FGF21 in obese mice reduced body weight, blood glucose and serum insulin, and increased insulin sensitivity, resulting in alleviation of insulin resistance.	Blood Glucose	63-76	fibroblast growth factor 21	Mus musculus	22-27
27939978-3	2017	Here we show that intraperitoneal injection of phentolamine (an alpha-adrenergic receptor antagonist, 5mg/kg) significantly increased plasma FGF21 levels compared with the saline controls in C57BL6J mice, whereas alprenolol (a beta-adrenergic receptor antagonist, 6mg/kg) had no effect.	Phentolamine	47-59	fibroblast growth factor 21	Mus musculus	141-146
27939978-4	2017	In addition, intraperitoneal injection of prazosin (an alpha1-adrenergic receptor antagonist, 5mg/kg) significantly increased plasma FGF21 levels compared with the controls, whereas yohimbine (an alpha2-adrenergic receptor antagonist, 5mg/kg) had no effect.	Prazosin	42-50	fibroblast growth factor 21	Mus musculus	133-138
27939978-5	2017	Moreover, the treatment with prazosin significantly increased the expression of hepatic FGF21, while having no effect on the expression of hepatic PPARalpha and PPARgamma.	Prazosin	29-37	fibroblast growth factor 21	Mus musculus	88-93
27939978-6	2017	After a 5-h fast, intraperitoneal injection of prazosin significantly increased plasma FGF21 levels and impaired glucose tolerance compared with controls.	Prazosin	47-55	fibroblast growth factor 21	Mus musculus	87-92
27818935-2	2016	Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression.	Glucose	29-36	fibroblast growth factor 21	Mus musculus	79-106
27643551-8	2016	These results suggest that using the treatment method of high dose of PEGylated FGF-21 in the start and low dose maintaining results in favorable control of the glycolipid metabolic balance.	Glycolipids	161-171	fibroblast growth factor 21	Mus musculus	80-86
27631137-2	2016	We previously reported that the inhibition of hepatic glucose production (HGP) protects against the development of obesity and diabetes despite severe steatosis, thanks to the secretion of specific hepatokines such as fibroblast growth factor 21 (FGF21) and angiopoietin-related growth factor.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	218-245
27631137-2	2016	We previously reported that the inhibition of hepatic glucose production (HGP) protects against the development of obesity and diabetes despite severe steatosis, thanks to the secretion of specific hepatokines such as fibroblast growth factor 21 (FGF21) and angiopoietin-related growth factor.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	247-252
27690692-0	2016	FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity.	Phospholipids	24-36	fibroblast growth factor 21	Mus musculus	0-5
27486236-1	2016	Fibroblast growth factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate and lipid metabolism, is considered a target for the treatment of diabetes.	Carbohydrates	83-95	fibroblast growth factor 21	Mus musculus	0-27
27486236-1	2016	Fibroblast growth factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate and lipid metabolism, is considered a target for the treatment of diabetes.	Carbohydrates	83-95	fibroblast growth factor 21	Mus musculus	29-34
27486236-7	2016	Enhanced Fgf21 expression attenuated tunicamycin-induced endoplasmic reticulum stress, as demonstrated by using a neutralizing antibody against FGF21.	Tunicamycin	37-48	fibroblast growth factor 21	Mus musculus	9-14
27486236-7	2016	Enhanced Fgf21 expression attenuated tunicamycin-induced endoplasmic reticulum stress, as demonstrated by using a neutralizing antibody against FGF21.	Tunicamycin	37-48	fibroblast growth factor 21	Mus musculus	144-149
27486236-8	2016	Of note, increased Fgf21 expression in mice fed a high-fat diet or hepatocytes exposed to palmitate was accompanied by reduced PPARbeta/delta and activation of the HRI-eIF2alpha-ATF4 pathway.	Palmitates	90-99	fibroblast growth factor 21	Mus musculus	19-24
27574977-0	2016	Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes.	Glucose	98-105	fibroblast growth factor 21	Mus musculus	138-143
27574977-3	2016	This study aimed to investigate how dietary carbohydrates and proteins impact FGF21 production and how in turn, FGF21 is involved in the metabolic adaptation to changes in the carbohydrate and protein contents of the diet.	Carbohydrates	44-57	fibroblast growth factor 21	Mus musculus	78-83
27574977-3	2016	This study aimed to investigate how dietary carbohydrates and proteins impact FGF21 production and how in turn, FGF21 is involved in the metabolic adaptation to changes in the carbohydrate and protein contents of the diet.	Carbohydrates	44-57	fibroblast growth factor 21	Mus musculus	112-117
27574977-3	2016	This study aimed to investigate how dietary carbohydrates and proteins impact FGF21 production and how in turn, FGF21 is involved in the metabolic adaptation to changes in the carbohydrate and protein contents of the diet.	Carbohydrates	44-56	fibroblast growth factor 21	Mus musculus	78-83
27574977-6	2016	We also investigated the direct role of amino acids and glucose in the control of Fgf21 gene expression in hepatocyte primary cultures (n=6).	Glucose	56-63	fibroblast growth factor 21	Mus musculus	82-87
27574977-8	2016	In hepatocytes, Fgf21 expression was controlled by glucose but not amino acids.	Glucose	51-58	fibroblast growth factor 21	Mus musculus	16-21
27574977-10	2016	The results presented suggest that dietary glucose, rather than amino acids, directly controls FGF21 secretion, and that FGF21 may be involved in the increased TEF response to LPHC.	Glucose	43-50	fibroblast growth factor 21	Mus musculus	95-100
28554169-0	2017	Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1alpha Signaling Axis.	neohesperidin	0-13	fibroblast growth factor 21	Mus musculus	71-98
28554169-10	2017	Furthermore, the siRNA or inhibitor targeting FGF21 or AMPK rejected the triglyceride-lowering effect of NHP.	Triglycerides	73-85	fibroblast growth factor 21	Mus musculus	46-51
27911795-5	2016	We show that brain-specific beta-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain.	Alcohols	109-116	fibroblast growth factor 21	Mus musculus	94-99
27690692-7	2016	These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.	Phospholipids	100-112	fibroblast growth factor 21	Mus musculus	35-40
27690692-7	2016	These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.	Phospholipids	243-255	fibroblast growth factor 21	Mus musculus	35-40
28123933-3	2017	Here, we sought to define the mechanism by which fructose ingestion regulates FGF21 and determine whether FGF21 contributes to an adaptive metabolic response to fructose consumption.	Fructose	49-57	fibroblast growth factor 21	Mus musculus	78-83
28123933-3	2017	Here, we sought to define the mechanism by which fructose ingestion regulates FGF21 and determine whether FGF21 contributes to an adaptive metabolic response to fructose consumption.	Fructose	161-169	fibroblast growth factor 21	Mus musculus	106-111
28123933-4	2017	METHODS: We tested the role of the transcription factor carbohydrate responsive-element binding protein (ChREBP) in fructose-mediated regulation of FGF21 using ChREBP knockout mice.	Fructose	116-124	fibroblast growth factor 21	Mus musculus	148-153
28123933-7	2017	RESULTS: Hepatic expression of ChREBP-beta and Fgf21 acutely increased 2-fold and 3-fold, respectively, following fructose gavage, and this was accompanied by increased circulating FGF21.	Fructose	114-122	fibroblast growth factor 21	Mus musculus	47-52
28123933-8	2017	The acute increase in circulating FGF21 following fructose gavage was absent in ChREBP knockout mice.	Fructose	50-58	fibroblast growth factor 21	Mus musculus	34-39
28123933-9	2017	Induction of ChREBP-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets, and this was accompanied by a 50% reduction in de novo lipogenesis a, 30% reduction VLDL secretion, and a 25% reduction in liver fat compared to fructose-fed controls.	Fructose	133-141	fibroblast growth factor 21	Mus musculus	104-109
28123933-9	2017	Induction of ChREBP-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets, and this was accompanied by a 50% reduction in de novo lipogenesis a, 30% reduction VLDL secretion, and a 25% reduction in liver fat compared to fructose-fed controls.	Fructose	294-302	fibroblast growth factor 21	Mus musculus	104-109
28123933-11	2017	After 8 weeks of high-fructose diet, livers from FGF21 knockout mice demonstrate atrophy and fibrosis accompanied by molecular markers of inflammation and stellate cell activation; whereas, this did not occur in controls.	Fructose	22-30	fibroblast growth factor 21	Mus musculus	49-54
27693377-2	2016	Although FGF21 is robustly elevated in low-protein environments, increased FGF21 is also seen in various other contexts such as fasting, overfeeding, ketogenic diets, and high-carbohydrate diets, leaving its nutritional context and physiological role unresolved and controversial.	Carbohydrates	176-188	fibroblast growth factor 21	Mus musculus	75-80
27693377-4	2016	We show that FGF21 was elevated under low protein intakes and maximally when low protein was coupled with high carbohydrate intakes.	Carbohydrates	111-123	fibroblast growth factor 21	Mus musculus	13-18
27818935-2	2016	Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression.	Triglycerides	41-53	fibroblast growth factor 21	Mus musculus	108-113
27818935-2	2016	Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression.	Glucose	29-36	fibroblast growth factor 21	Mus musculus	108-113
27818935-2	2016	Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression.	Triglycerides	41-53	fibroblast growth factor 21	Mus musculus	79-106
27435856-2	2016	In this research, Monosodium L-glutamate (MSG)-induced obese mice or normal lean mice were treated with vehicle, Fenofibrate, and recombinant murine FGF21, respectively.	Sodium Glutamate	18-40	fibroblast growth factor 21	Mus musculus	149-154
27445299-7	2016	Physiological tests were performed to assess the role of FGF21 in the beneficial effect of exercise on glucose metabolism.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	57-62
27583468-3	2016	FGF21 is predominantly produced by the liver but also by other tissues, such as white adipose tissue (WAT), brown adipose tissue (BAT), skeletal muscle, and pancreas in response to different stimuli such as cold and different nutritional challenges that include fasting, high-fat diets (HFDs), ketogenic diets, some amino acid-deficient diets, low protein diets, high carbohydrate diets or specific dietary bioactive compounds.	Carbohydrates	368-380	fibroblast growth factor 21	Mus musculus	0-5
27276443-6	2016	FGF21 also suppressed profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level, and restored the activities of antioxidant enzymes SOD and GSH-Px in LPS-stimulated RAW 264.7 macrophages.	ros	44-47	fibroblast growth factor 21	Mus musculus	0-5
27276443-6	2016	FGF21 also suppressed profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level, and restored the activities of antioxidant enzymes SOD and GSH-Px in LPS-stimulated RAW 264.7 macrophages.	Glutathione	161-164	fibroblast growth factor 21	Mus musculus	0-5
27276443-6	2016	FGF21 also suppressed profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level, and restored the activities of antioxidant enzymes SOD and GSH-Px in LPS-stimulated RAW 264.7 macrophages.	gsh-px	231-237	fibroblast growth factor 21	Mus musculus	0-5
27435856-7	2016	Results showed that FGF21 significantly reduced body weight (P < 0.01) and serum triglyceride, improved insulin sensitivity, and reversed hepatic steatosis in the MSG model mice.	Triglycerides	84-96	fibroblast growth factor 21	Mus musculus	20-25
27583452-0	2016	Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice.	Simvastatin	44-55	fibroblast growth factor 21	Mus musculus	8-13
27583452-1	2016	Fibroblast growth factor 21 (Fgf21) is a hormone with emerging beneficial roles in glucose and lipid homeostasis.	Glucose	83-90	fibroblast growth factor 21	Mus musculus	0-27
27583452-1	2016	Fibroblast growth factor 21 (Fgf21) is a hormone with emerging beneficial roles in glucose and lipid homeostasis.	Glucose	83-90	fibroblast growth factor 21	Mus musculus	29-34
27583452-7	2016	Hepatic Fgf21 protein and mRNA and circulating levels of FGF21significantly decreased in mice that had received simvastatin in their food (0.1% w/w) for 1 week.	Simvastatin	112-123	fibroblast growth factor 21	Mus musculus	8-13
27583452-7	2016	Hepatic Fgf21 protein and mRNA and circulating levels of FGF21significantly decreased in mice that had received simvastatin in their food (0.1% w/w) for 1 week.	Simvastatin	112-123	fibroblast growth factor 21	Mus musculus	57-62
27583452-9	2016	The reduction in Fgf21 mRNA levels was further verified in primary mouse hepatocytes, indicating that the effect of simvastatin is cell autonomous.	Simvastatin	116-127	fibroblast growth factor 21	Mus musculus	17-22
27583452-10	2016	In conclusion, simvastatin treatment reduced the circulating and hepatic Fgf21 levels and this effect warrants further investigation with reference to its role in metabolism.	Simvastatin	15-26	fibroblast growth factor 21	Mus musculus	73-78
27498701-9	2016	FGF21 depletion exacerbated alcohol-induced hepatic steatosis and liver injury, which was associated with increased activation of genes involved in lipogenesis mediated by SREBP1c and decreased expression of genes involved in fatty acid beta-oxidation mediated by PGC1alpha.	Fatty Acids	226-236	fibroblast growth factor 21	Mus musculus	0-5
27498701-0	2016	Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury.	Alcohols	59-66	fibroblast growth factor 21	Mus musculus	0-27
27498701-1	2016	Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver.	Glucose	67-74	fibroblast growth factor 21	Mus musculus	0-27
27498701-1	2016	Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver.	Glucose	67-74	fibroblast growth factor 21	Mus musculus	29-34
27498701-2	2016	We sought to determine the role of FGF21 in hepatic steatosis in mice exposed to chronic alcohol treatment and to discern underlying mechanisms.	Alcohols	89-96	fibroblast growth factor 21	Mus musculus	35-40
27498701-8	2016	Alcohol exposure increased circulating levels and hepatic expression of FGF21.	Alcohols	0-7	fibroblast growth factor 21	Mus musculus	72-77
27498701-9	2016	FGF21 depletion exacerbated alcohol-induced hepatic steatosis and liver injury, which was associated with increased activation of genes involved in lipogenesis mediated by SREBP1c and decreased expression of genes involved in fatty acid beta-oxidation mediated by PGC1alpha.	Alcohols	28-35	fibroblast growth factor 21	Mus musculus	0-5
27498701-11	2016	These results reveal that alcohol-induced FGF21 expression is a hepatic adaptive response to lipid dysregulation.	Alcohols	26-33	fibroblast growth factor 21	Mus musculus	42-47
27339749-9	2016	In DIO mice, administration of PsTag fused to FGF21 reduced body weight, blood glucose and lipids levels and reversed hepatic steatosis.	Blood Glucose	73-86	fibroblast growth factor 21	Mus musculus	46-51
26926384-6	2016	TSC1 deficiency abrogates FGF21-mediated inhibition of mTORC1 and augmentation of insulin signaling and glycogen synthesis.	Glycogen	104-112	fibroblast growth factor 21	Mus musculus	26-31
26926384-8	2016	Moreover, FGF21 improves methionine- and choline-deficient diet-induced steatohepatitis.	Methionine	25-35	fibroblast growth factor 21	Mus musculus	10-15
26926384-8	2016	Moreover, FGF21 improves methionine- and choline-deficient diet-induced steatohepatitis.	Choline	41-48	fibroblast growth factor 21	Mus musculus	10-15
27455076-1	2016	BACKGROUND: Fibroblast growth factor 21 (FGF21), a stress inducible hepatokine, is synthesized in the liver and plays important roles in glucose and lipid metabolism.	Glucose	137-144	fibroblast growth factor 21	Mus musculus	12-39
27455076-1	2016	BACKGROUND: Fibroblast growth factor 21 (FGF21), a stress inducible hepatokine, is synthesized in the liver and plays important roles in glucose and lipid metabolism.	Glucose	137-144	fibroblast growth factor 21	Mus musculus	41-46
27455076-3	2016	RESULTS: Activation of the hepatic CB1 receptor by arachidonyl-2"-chloroethylamide (ACEA), a CB1 receptor selective agonist, significantly increased FGF21 gene expression.	arachidonyl-2-chloroethylamide	51-82	fibroblast growth factor 21	Mus musculus	149-154
27455076-3	2016	RESULTS: Activation of the hepatic CB1 receptor by arachidonyl-2"-chloroethylamide (ACEA), a CB1 receptor selective agonist, significantly increased FGF21 gene expression.	arachidonyl-2-chloroethylamide	84-88	fibroblast growth factor 21	Mus musculus	149-154
27455076-8	2016	Finally, GSK5182, an ERRgamma inverse agonist, significantly inhibited hepatic CB1 receptor-mediated FGF21 gene expression and secretion.	GSK5182	9-16	fibroblast growth factor 21	Mus musculus	101-106
27226639-7	2016	The Fgf21 promoter contains several putative dioxin response elements (DREs).	Dioxins	45-51	fibroblast growth factor 21	Mus musculus	4-9
27470139-3	2016	The plasma Fgf21 level significantly correlated with intrahepatic triglyceride content.	Triglycerides	66-78	fibroblast growth factor 21	Mus musculus	11-16
27689014-7	2016	Total and intact plasma FGF21 were observed to be elevated in TB-treated DIO mice but not lean animals where the metabolic impact of TB was significantly attenuated.	talabostat	62-64	fibroblast growth factor 21	Mus musculus	24-29
27689014-8	2016	Furthermore, and in stark contrast to naive DIO mice, the administration of TB to obese FGF21 knockout animals demonstrated no appreciable effect on body weight or any other measures of metabolism.	talabostat	76-78	fibroblast growth factor 21	Mus musculus	88-93
27312476-7	2016	Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling.	Methionine	0-10	fibroblast growth factor 21	Mus musculus	144-149
27367842-5	2016	Certain PPARalpha target genes such as Fgf21 remain repressed in the fetal liver and become PPARalpha responsive after birth following an epigenetic switch triggered by beta-hydroxybutyrate-mediated inhibition of HDAC3.	3-Hydroxybutyric Acid	169-189	fibroblast growth factor 21	Mus musculus	39-44
27445980-2	2016	To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carbohydrate metabolism.	Carbohydrates	194-206	fibroblast growth factor 21	Mus musculus	40-45
26607153-0	2016	Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway.	Glucose	28-35	fibroblast growth factor 21	Mus musculus	19-24
27089817-0	2016	Long-lasting hypoglycemic effect of modified FGF-21 analog with polyethylene glycol in type 1 diabetic mice and its systematic toxicity.	Polyethylene Glycols	64-83	fibroblast growth factor 21	Mus musculus	45-51
27089817-3	2016	In this study, The N-terminus of FGF-21 analog (mFGF-21) was PEGylated in a site-specific manner by 20kD methoxy poly-ethylene glycol-propionaldehyde (mPEG-ALD).	methoxy poly-ethylene glycol-propionaldehyde	105-149	fibroblast growth factor 21	Mus musculus	33-39
27089817-3	2016	In this study, The N-terminus of FGF-21 analog (mFGF-21) was PEGylated in a site-specific manner by 20kD methoxy poly-ethylene glycol-propionaldehyde (mPEG-ALD).	methoxy poly-ethylene glycol-propionaldehyde	105-149	fibroblast growth factor 21	Mus musculus	48-55
27089817-4	2016	PEGylated mFGF-21 was isolated by Capto Q anion exchange chromatography.	capto	34-39	fibroblast growth factor 21	Mus musculus	10-17
27089817-7	2016	Results demonstrated that PEGylated mFGF-21 had a similar capacity of stimulating glucose uptake in HepG2 cells with mFGF-21 and PEGylation of mFGF-21 significantly enhanced the anti-protease ability and the long acting anti-diabetic effect in type 1 diabetic mice.	Glucose	82-89	fibroblast growth factor 21	Mus musculus	36-43
26607153-1	2016	Previous studies reveal that fibroblast growth factor 21 (FGF21) sensitizes insulin to achieve a synergy in regulating glucose metabolism.	Glucose	119-126	fibroblast growth factor 21	Mus musculus	29-56
26607153-1	2016	Previous studies reveal that fibroblast growth factor 21 (FGF21) sensitizes insulin to achieve a synergy in regulating glucose metabolism.	Glucose	119-126	fibroblast growth factor 21	Mus musculus	58-63
26607153-2	2016	Here, we report that insulin sensitizes FGF21 in regulating both glucose and lipid metabolisms.	Glucose	65-72	fibroblast growth factor 21	Mus musculus	40-45
26607153-5	2016	In contrast, effective dose of FGF21 (0.5 mg/kg) could maintain blood glucose of the db/db mice at normal level for at least 24 h, repressed the weight gain of the mice and significantly improved lipid parameters.	Glucose	70-77	fibroblast growth factor 21	Mus musculus	31-36
26607153-8	2016	These results suggest that insulin sensitizes FGF21 in regulating both glucose and lipid metabolism.	Glucose	71-78	fibroblast growth factor 21	Mus musculus	46-51
26607153-11	2016	In summary, we reports herein for the first time that insulin sensitizes FGF21 to achieve a synergy in regulating glucose and lipid metabolism.	Glucose	114-121	fibroblast growth factor 21	Mus musculus	73-78
27002153-1	2016	FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism.	Carbohydrates	86-98	fibroblast growth factor 21	Mus musculus	0-5
27335433-1	2016	Fibroblast growth factor 21, a metabolic regulator, plays roles in lipolysis and glucose uptake in adipose tissues and skeletal muscles.	Glucose	81-88	fibroblast growth factor 21	Mus musculus	0-27
27184848-6	2016	FGF21 appears to act in a paracrine manner to increase glucose uptake under low insulin conditions, but it does not contribute to the resistance to diet-induced obesity.	Glucose	55-62	fibroblast growth factor 21	Mus musculus	0-5
27012775-4	2016	FGF21 deficiency resulted in greater body weight, adiposity, serum cholesterol, insulin, and glucose concentrations compared with WT mice (P < 0.05).	Cholesterol	67-78	fibroblast growth factor 21	Mus musculus	0-5
27012775-4	2016	FGF21 deficiency resulted in greater body weight, adiposity, serum cholesterol, insulin, and glucose concentrations compared with WT mice (P < 0.05).	Glucose	93-100	fibroblast growth factor 21	Mus musculus	0-5
27012775-5	2016	In addition, hepatic mitochondrial complete palmitate oxidation, beta-hydroxyacyl-CoA dehydrogenase (beta-HAD) activity, and nuclear content of PGC-1alpha were 30-50% lower in FGF21-KO mice compared with WT mice (P < 0.01).	Palmitates	44-53	fibroblast growth factor 21	Mus musculus	176-181
27002153-1	2016	FGF21 is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism.	Carbohydrates	86-98	fibroblast growth factor 21	Mus musculus	0-3
26858359-0	2016	Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.	Betaine	8-15	fibroblast growth factor 21	Mus musculus	42-47
27293995-5	2016	NASH was induced in FGF21 knockout (FGF21KO) mice by streptozotocin administration or fed with high fat diet (HFD).	Streptozocin	53-67	fibroblast growth factor 21	Mus musculus	20-25
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	32-34	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	32-34	fibroblast growth factor 21	Mus musculus	211-216
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	35-40	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	35-40	fibroblast growth factor 21	Mus musculus	211-216
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	42-47	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Water	42-47	fibroblast growth factor 21	Mus musculus	211-216
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	61-63	fibroblast growth factor 21	Mus musculus	182-209
28721265-2	2016	Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism.	Hydrogen	61-63	fibroblast growth factor 21	Mus musculus	211-216
28721265-12	2016	H2 induces expression of the PGC-1alpha gene, followed by stimulation of the PPARalpha pathway that regulates FGF21, and the fatty acid and steroid metabolism.	Hydrogen	0-2	fibroblast growth factor 21	Mus musculus	110-115
26795437-0	2016	Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice.	Fenofibrate	0-11	fibroblast growth factor 21	Mus musculus	44-49
26795437-7	2016	FF treatment prevented heart deterioration in the wild-type diabetic mice, but could not do so in the FGF21-KO diabetic mice although the systemic lipid profile was lowered in both wild-type and FGF21-KO diabetic mice.	Fenofibrate	0-2	fibroblast growth factor 21	Mus musculus	195-200
26858359-5	2016	In parallel with these beneficial metabolic effects, betaine supplementation robustly increased hepatic and circulating fibroblast growth factor (Fgf)21 levels.	Betaine	53-60	fibroblast growth factor 21	Mus musculus	146-152
26858359-6	2016	Betaine administration failed to improve glucose homeostasis and liver fat content in Fgf21(-/-) mice, demonstrating that Fgf21 is necessary for betaine"s beneficial effects.	Betaine	145-152	fibroblast growth factor 21	Mus musculus	122-127
26740596-2	2016	In addition, fibroblast growth factor (FGF)21 has effects similar to those of adiponectin in regulating glucose and lipid metabolism and insulin sensitivity.	Glucose	104-111	fibroblast growth factor 21	Mus musculus	39-45
26858359-7	2016	Together, these data indicate that dietary betaine increases Fgf21 levels to improve metabolic health in mice and suggest that betaine supplementation merits further investigation as a supplement for treatment or prevention of type 2 diabetes in humans.	Betaine	43-50	fibroblast growth factor 21	Mus musculus	61-66
26849944-0	2016	Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy.	Fenofibrate	52-63	fibroblast growth factor 21	Mus musculus	37-42
26849944-8	2016	Moreover, FF-induced amelioration of diabetic renal damage, including the stimulation of PI3K/Akt/GSK-3beta/Fyn pathway and the enhancement of Nrf2 function were abolished in FGF21-null mice, confirming the critical role of FGF21 in FF-induced renal protection.	Fenofibrate	10-12	fibroblast growth factor 21	Mus musculus	175-180
26849944-8	2016	Moreover, FF-induced amelioration of diabetic renal damage, including the stimulation of PI3K/Akt/GSK-3beta/Fyn pathway and the enhancement of Nrf2 function were abolished in FGF21-null mice, confirming the critical role of FGF21 in FF-induced renal protection.	Fenofibrate	10-12	fibroblast growth factor 21	Mus musculus	224-229
26769382-0	2016	Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway.	Lactic Acid	0-7	fibroblast growth factor 21	Mus musculus	16-21
26993043-7	2016	Furthermore, the glucose-lowering, lipid-clearing, and anti-atherosclerotic functions of FGF21 are diminished in adiponectin-null mice, suggesting that adiponectin serves as an obligatory mediator of FGF21-elicited metabolic and vascular benefits.	Glucose	17-24	fibroblast growth factor 21	Mus musculus	89-94
26769382-2	2016	In the present study, we found that the expression and secretion of FGF21 was very rapidly increased following lactate exposure in adipocytes.	Lactic Acid	111-118	fibroblast growth factor 21	Mus musculus	68-73
26769382-3	2016	Using different pharmacological and knockout mice models, we demonstrated that lactate regulates Fgf21 expression through a NADH/NAD-independent pathway, but requires active p38-MAPK (mitogen activated protein kinase) signalling.	Lactic Acid	79-86	fibroblast growth factor 21	Mus musculus	97-102
26769382-3	2016	Using different pharmacological and knockout mice models, we demonstrated that lactate regulates Fgf21 expression through a NADH/NAD-independent pathway, but requires active p38-MAPK (mitogen activated protein kinase) signalling.	NAD	124-128	fibroblast growth factor 21	Mus musculus	97-102
26769382-3	2016	Using different pharmacological and knockout mice models, we demonstrated that lactate regulates Fgf21 expression through a NADH/NAD-independent pathway, but requires active p38-MAPK (mitogen activated protein kinase) signalling.	NAD	124-127	fibroblast growth factor 21	Mus musculus	97-102
26769382-4	2016	We also demonstrated that this effect is not restricted to lactate as additional metabolites including pyruvate and ketone bodies also activated the FGF21 stress response.	Lactic Acid	59-66	fibroblast growth factor 21	Mus musculus	149-154
26769382-4	2016	We also demonstrated that this effect is not restricted to lactate as additional metabolites including pyruvate and ketone bodies also activated the FGF21 stress response.	Pyruvic Acid	103-111	fibroblast growth factor 21	Mus musculus	149-154
26769382-4	2016	We also demonstrated that this effect is not restricted to lactate as additional metabolites including pyruvate and ketone bodies also activated the FGF21 stress response.	Ketones	116-122	fibroblast growth factor 21	Mus musculus	149-154
26853749-0	2016	FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues.	Triglycerides	20-33	fibroblast growth factor 21	Mus musculus	0-5
26853749-3	2016	Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion.	esterified	73-83	fibroblast growth factor 21	Mus musculus	40-45
26853749-3	2016	Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion.	Fatty Acids	84-95	fibroblast growth factor 21	Mus musculus	40-45
26853749-3	2016	Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion.	Fatty Acids, Nonesterified	97-102	fibroblast growth factor 21	Mus musculus	40-45
26853749-3	2016	Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion.	Triglycerides	111-113	fibroblast growth factor 21	Mus musculus	40-45
26853749-3	2016	Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion.	Triglycerides	132-134	fibroblast growth factor 21	Mus musculus	40-45
26876280-4	2016	In doing so, it was shown that short-term and long-term ALA treatment caused a marked increase of beta-oxidation, as indicated by a significant rise of mRNA expression of fgf21, pparalpha, and its target genes, for example, acox1, cpt1alpha, and cpt2, as well as of Fgf21 plasma concentration.	Thioctic Acid	56-59	fibroblast growth factor 21	Mus musculus	171-176
26876280-4	2016	In doing so, it was shown that short-term and long-term ALA treatment caused a marked increase of beta-oxidation, as indicated by a significant rise of mRNA expression of fgf21, pparalpha, and its target genes, for example, acox1, cpt1alpha, and cpt2, as well as of Fgf21 plasma concentration.	Thioctic Acid	56-59	fibroblast growth factor 21	Mus musculus	266-271
26724858-0	2016	FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.	Sugars	43-48	fibroblast growth factor 21	Mus musculus	0-5
26872317-0	2016	The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion.	Amino Acids, Essential	13-33	fibroblast growth factor 21	Mus musculus	125-130
26872317-6	2016	The ability of FGF21 to decrease LDL cholesterol has now been traced to at least two mechanisms: a suppression of hepatocyte expression of sterol response element-binding protein-2 (SREBP-2), which in turn leads to a reduction in cholesterol synthesis; and up-regulated expression of hepatocyte LDL receptors, reflecting inhibition of a mechanism that promotes proteasomal degradation of these receptors.	Cholesterol	37-48	fibroblast growth factor 21	Mus musculus	15-20
26872317-6	2016	The ability of FGF21 to decrease LDL cholesterol has now been traced to at least two mechanisms: a suppression of hepatocyte expression of sterol response element-binding protein-2 (SREBP-2), which in turn leads to a reduction in cholesterol synthesis; and up-regulated expression of hepatocyte LDL receptors, reflecting inhibition of a mechanism that promotes proteasomal degradation of these receptors.	Cholesterol	230-241	fibroblast growth factor 21	Mus musculus	15-20
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Carbohydrates	38-50	fibroblast growth factor 21	Mus musculus	95-122
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Carbohydrates	38-50	fibroblast growth factor 21	Mus musculus	124-129
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Sugars	180-186	fibroblast growth factor 21	Mus musculus	95-122
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Sugars	180-186	fibroblast growth factor 21	Mus musculus	124-129
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Carbohydrates	204-217	fibroblast growth factor 21	Mus musculus	95-122
26724858-2	2016	Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.	Carbohydrates	204-217	fibroblast growth factor 21	Mus musculus	124-129
26724858-3	2016	Genetic loss of FGF21 in mice increases sucrose consumption, whereas acute administration or overexpression of FGF21 suppresses the intake of both sugar and non-caloric sweeteners.	Sucrose	40-47	fibroblast growth factor 21	Mus musculus	16-21
26724858-3	2016	Genetic loss of FGF21 in mice increases sucrose consumption, whereas acute administration or overexpression of FGF21 suppresses the intake of both sugar and non-caloric sweeteners.	Sugars	147-152	fibroblast growth factor 21	Mus musculus	111-116
26724858-5	2016	This liver-to-brain hormonal axis likely represents a negative feedback loop as hepatic FGF21 production is elevated by sucrose ingestion.	Sucrose	120-127	fibroblast growth factor 21	Mus musculus	88-93
26724861-3	2016	Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys.	Alcohols	66-73	fibroblast growth factor 21	Mus musculus	18-23
26724861-4	2016	In mice, these effects require the FGF21 co-receptor beta-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens.	Dopamine	128-136	fibroblast growth factor 21	Mus musculus	35-40
26983476-0	2016	[Role and mechanism of action of fibroblast growth factor-21 in reducing triglyceride in nonalcoholic fatty liver disease].	Triglycerides	73-85	fibroblast growth factor 21	Mus musculus	33-60
26764334-0	2016	Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet.	Carbohydrates	96-108	fibroblast growth factor 21	Mus musculus	0-27
26764334-0	2016	Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet.	Carbohydrates	96-108	fibroblast growth factor 21	Mus musculus	29-34
26764334-1	2016	BACKGROUND: Fibroblast growth factor 21 (FGF21) is a regulator of carbohydrate and lipid metabolism; however, the regulation of Fgf21 gene expression by diet remains incompletely understood.	Carbohydrates	66-78	fibroblast growth factor 21	Mus musculus	12-39
26764334-1	2016	BACKGROUND: Fibroblast growth factor 21 (FGF21) is a regulator of carbohydrate and lipid metabolism; however, the regulation of Fgf21 gene expression by diet remains incompletely understood.	Carbohydrates	66-78	fibroblast growth factor 21	Mus musculus	41-46
26764334-11	2016	Our results support a strong and reversible response of hepatic Fgf21 expression to shifts in dietary glucose intake.	Glucose	102-109	fibroblast growth factor 21	Mus musculus	64-69
26983476-1	2016	OBJECTIVE: To investigate the role and mechanism of action of fibroblast growth factor-21 (FGF-21) in reducing triglyceride (TG) in the in vitro and in vivo models of nonalcoholic fatty liver disease (NAFLD).	Triglycerides	111-123	fibroblast growth factor 21	Mus musculus	62-89
26983476-1	2016	OBJECTIVE: To investigate the role and mechanism of action of fibroblast growth factor-21 (FGF-21) in reducing triglyceride (TG) in the in vitro and in vivo models of nonalcoholic fatty liver disease (NAFLD).	Triglycerides	111-123	fibroblast growth factor 21	Mus musculus	91-97
26983476-1	2016	OBJECTIVE: To investigate the role and mechanism of action of fibroblast growth factor-21 (FGF-21) in reducing triglyceride (TG) in the in vitro and in vivo models of nonalcoholic fatty liver disease (NAFLD).	Triglycerides	125-127	fibroblast growth factor 21	Mus musculus	62-89
26983476-1	2016	OBJECTIVE: To investigate the role and mechanism of action of fibroblast growth factor-21 (FGF-21) in reducing triglyceride (TG) in the in vitro and in vivo models of nonalcoholic fatty liver disease (NAFLD).	Triglycerides	125-127	fibroblast growth factor 21	Mus musculus	91-97
26654352-4	2016	In the liver, FGF21 plays an important role in the regulation of fatty acid oxidation both in the fasted state and in mice consuming a high-fat, low-carbohydrate ketogenic diet.	Fatty Acids	65-75	fibroblast growth factor 21	Mus musculus	14-19
26654352-4	2016	In the liver, FGF21 plays an important role in the regulation of fatty acid oxidation both in the fasted state and in mice consuming a high-fat, low-carbohydrate ketogenic diet.	Carbohydrates	149-161	fibroblast growth factor 21	Mus musculus	14-19
26654352-5	2016	FGF21 also regulates fatty acid metabolism in mice consuming a diet that promotes hepatic lipotoxicity.	Fatty Acids	21-31	fibroblast growth factor 21	Mus musculus	0-5
27057099-9	2016	Metformin suppressed white adipocyte differentiation via induction of FGF21.	Metformin	0-9	fibroblast growth factor 21	Mus musculus	70-75
26909316-6	2016	Strikingly, genetic ablation of FGF21 fully counteracted the cell-non-autonomous metabolic remodeling and browning of subcutaneous white adipose tissue (WAT), together with the reduction of circulating triglycerides and cholesterol.	Triglycerides	202-215	fibroblast growth factor 21	Mus musculus	32-37
26586424-1	2015	Fibroblast growth factor 21 (FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action.	Glucose	77-84	fibroblast growth factor 21	Mus musculus	29-34
26586424-3	2015	We find while FGF21 can lower body weight in both wild-type and Ucp1 knockout mice, rapid clearance of glucose by FGF21 is defective in the absence of UCP1.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	114-119
26586424-4	2015	Furthermore, in obese wild-type mice there is a fall in brown adipose tissue (BAT) temperature during glucose excursion, and FGF21 improves glucose clearance while preventing the fall in BAT temperature.	Glucose	140-147	fibroblast growth factor 21	Mus musculus	125-130
26586424-6	2015	We conclude FGF21-mediated improvements in clearance of a glucose challenge require UCP1 and evoke UCP1-dependent thermogenesis as a method to increase glucose disposal.	Glucose	58-65	fibroblast growth factor 21	Mus musculus	12-17
27057099-0	2016	Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21.	Metformin	0-9	fibroblast growth factor 21	Mus musculus	113-118
27057099-8	2016	In obese mice, metformin also induced the expression of BAT-related markers and increased fibroblast growth factor (FGF) 21 expression in the liver and in white adipocyte.	Metformin	15-24	fibroblast growth factor 21	Mus musculus	90-123
26592322-2	2016	In this study, we investigated the ability of FGF-21 to attenuate dimethylnitrosamine (DMN)-induced hepatic fibrogenesis in mice and the mechanism of its action.	Dimethylnitrosamine	66-85	fibroblast growth factor 21	Mus musculus	46-52
26592322-2	2016	In this study, we investigated the ability of FGF-21 to attenuate dimethylnitrosamine (DMN)-induced hepatic fibrogenesis in mice and the mechanism of its action.	Dimethylnitrosamine	87-90	fibroblast growth factor 21	Mus musculus	46-52
26592322-6	2016	Results showed that FGF-21 treatment attenuated hepatic fibrogenesis and was associated with a significant decrease in intrahepatic fibrogenesis, 4-hydroxyproline accumulation, alpha-SMA expression and collagen I deposition.	Hydroxyproline	146-162	fibroblast growth factor 21	Mus musculus	20-26
26741352-3	2015	Transcriptional factors which promote hepatic FGF21 expression include PPARalpha, ATF4, STAT5, and FXR; hence, fibrate drugs, elevated lipolysis, moderate-protein vegan diets, growth hormone, and bile acids may have potential to increase FGF21 synthesis.	Bile Acids and Salts	196-206	fibroblast growth factor 21	Mus musculus	46-51
26741352-5	2015	Conversely, histone deacetylase 3 (HDAC3) inhibits PPARalpha"s transcriptional impact on FGF21, and type 1 deacetylase inhibitors such as butyrate therefore increase FGF21 expression.	Butyrates	138-146	fibroblast growth factor 21	Mus musculus	166-171
26741352-7	2015	Glucagon stimulates hepatic production of FGF21 by increasing the expression of the Nur77 transcription factor; increased glucagon secretion can be evoked by supplemental glycine administered during post-absorptive metabolism.	Glucagon	0-8	fibroblast growth factor 21	Mus musculus	42-47
26741352-9	2015	Bilirubin is known to be an agonist for this receptor, and this may rationalize a recent report that heme oxygenase-1 induction in the liver boosts FGF21 expression.	Bilirubin	0-9	fibroblast growth factor 21	Mus musculus	148-153
26741352-10	2015	There is reason to suspect that phycocyanorubin, a bilirubin homolog that is a metabolite of the major phycobilin in spirulina, may share bilirubin"s agonist activity for AhR, and perhaps likewise promote FGF21 induction.	phycocyanorubin	32-47	fibroblast growth factor 21	Mus musculus	205-210
26741352-10	2015	There is reason to suspect that phycocyanorubin, a bilirubin homolog that is a metabolite of the major phycobilin in spirulina, may share bilirubin"s agonist activity for AhR, and perhaps likewise promote FGF21 induction.	Bilirubin	138-147	fibroblast growth factor 21	Mus musculus	205-210
26537193-0	2015	TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways.	2-butyl-5-methyl-6-(pyridine-3-yl)-3-(2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl)-3H-imidazo(4,5-b)pyridine	0-8	fibroblast growth factor 21	Mus musculus	31-36
26537193-13	2015	These data indicate that TM-25659 may be beneficial for treating insulin resistance by inducing FGF21 in models of PA-induced insulin resistance and HF diet-induced insulin resistance.	Palmitates	115-117	fibroblast growth factor 21	Mus musculus	96-101
26586424-0	2015	FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1.	Glucose	31-38	fibroblast growth factor 21	Mus musculus	0-5
26586424-6	2015	We conclude FGF21-mediated improvements in clearance of a glucose challenge require UCP1 and evoke UCP1-dependent thermogenesis as a method to increase glucose disposal.	Glucose	152-159	fibroblast growth factor 21	Mus musculus	12-17
26909316-6	2016	Strikingly, genetic ablation of FGF21 fully counteracted the cell-non-autonomous metabolic remodeling and browning of subcutaneous white adipose tissue (WAT), together with the reduction of circulating triglycerides and cholesterol.	Cholesterol	220-231	fibroblast growth factor 21	Mus musculus	32-37
26144370-5	2015	The increase in fasting plasma glucose induced by STZ in untreated mice was prevented with FGF21 at 0.3 mg/kg BID.	Glucose	31-38	fibroblast growth factor 21	Mus musculus	91-96
26554817-5	2015	These differences were due to increased plasma concentrations of fibroblast growth factor 21 (FGF21), a hormone that stimulates glucose uptake and fatty acid oxidation.	Glucose	128-135	fibroblast growth factor 21	Mus musculus	65-92
26554817-5	2015	These differences were due to increased plasma concentrations of fibroblast growth factor 21 (FGF21), a hormone that stimulates glucose uptake and fatty acid oxidation.	Glucose	128-135	fibroblast growth factor 21	Mus musculus	94-99
26554817-5	2015	These differences were due to increased plasma concentrations of fibroblast growth factor 21 (FGF21), a hormone that stimulates glucose uptake and fatty acid oxidation.	Fatty Acids	147-157	fibroblast growth factor 21	Mus musculus	65-92
26554817-5	2015	These differences were due to increased plasma concentrations of fibroblast growth factor 21 (FGF21), a hormone that stimulates glucose uptake and fatty acid oxidation.	Fatty Acids	147-157	fibroblast growth factor 21	Mus musculus	94-99
26330054-5	2015	FGF21 is a polypeptide hormone that regulates glucose and lipid metabolism.	Glucose	46-53	fibroblast growth factor 21	Mus musculus	0-5
26330054-9	2015	Fgf21-KO mice showed greater epididymal white adipose tissue weight and increased hepatic TAG and cholesterol levels under protein malnutrition conditions (P<0 05).	Cholesterol	98-109	fibroblast growth factor 21	Mus musculus	0-5
26144370-5	2015	The increase in fasting plasma glucose induced by STZ in untreated mice was prevented with FGF21 at 0.3 mg/kg BID.	Streptozocin	50-53	fibroblast growth factor 21	Mus musculus	91-96
26144370-7	2015	At the end of the study, plasma glucagon was significantly higher in the diabetic group treated with FGF21 1.0 mg/kg BID than in the untreated group.	Glucagon	32-40	fibroblast growth factor 21	Mus musculus	101-106
26144370-9	2015	There were significant dose dependent reductions in plasma free fatty acids with FGF21 treatment but no significant change in plasma ketones (beta-hydroxybutyrate).	Fatty Acids, Nonesterified	59-75	fibroblast growth factor 21	Mus musculus	81-86
26144370-11	2015	In conclusion, FGF21 prevents increases in glycaemia and has lipid lowering properties in mouse models of insulin deficient diabetes, although by increasing the dose increased glucagon levels are seen and hyperglycemia persists.	Glucagon	176-184	fibroblast growth factor 21	Mus musculus	15-20
26338887-12	2015	Finally, curcumin gavage increased FGF21 expression by 2.1-fold in the mouse liver (P < 0.05) and curcumin treatment increased FGF21 expression in primary hepatocytes.	Curcumin	9-17	fibroblast growth factor 21	Mus musculus	35-40
26099854-2	2015	The metabolic benefits of KDs are regularly ascribed to enhanced hepatic secretion of fibroblast growth factor 21 (FGF21) and its systemic effects on fatty-acid oxidation, energy expenditure (EE) and body weight.	Fatty Acids	150-160	fibroblast growth factor 21	Mus musculus	86-113
26003555-1	2015	PURPOSE: In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice.	Diethylnitrosamine	80-98	fibroblast growth factor 21	Mus musculus	59-65
26003555-1	2015	PURPOSE: In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice.	Diethylnitrosamine	100-103	fibroblast growth factor 21	Mus musculus	59-65
26003555-6	2015	We found that FGF-21 could suppress DEN-induced oxidative stress and up-regulate the expression of KLB in the livers.	Diethylnitrosamine	36-39	fibroblast growth factor 21	Mus musculus	14-20
26003555-8	2015	Besides, we established DEN-induced oxidative stress cell model to affirm the relationship between FGF-21 and DEN-induced oxidative stress in vitro.	Diethylnitrosamine	24-27	fibroblast growth factor 21	Mus musculus	99-105
26003555-8	2015	Besides, we established DEN-induced oxidative stress cell model to affirm the relationship between FGF-21 and DEN-induced oxidative stress in vitro.	Diethylnitrosamine	110-113	fibroblast growth factor 21	Mus musculus	99-105
26003555-9	2015	Results showed that FGF-21 increased the expression of KLB and diminished the DEN-induced oxidative stress in vitro in a dose dependent manner.	Diethylnitrosamine	78-81	fibroblast growth factor 21	Mus musculus	20-26
26003555-10	2015	CONCLUSION: Systemic administration of FGF-21 can prevent DEN-induced hepatocarcinogenesis via suppressing oxidative stress and increasing the expression of KLB.	Diethylnitrosamine	58-61	fibroblast growth factor 21	Mus musculus	39-45
26338887-12	2015	Finally, curcumin gavage increased FGF21 expression by 2.1-fold in the mouse liver (P < 0.05) and curcumin treatment increased FGF21 expression in primary hepatocytes.	Curcumin	101-109	fibroblast growth factor 21	Mus musculus	130-135
26338887-13	2015	CONCLUSION: These observations suggest that the early beneficial effect of curcumin intervention in dexamethasone-treated mice is the sensitization of insulin signaling, involving the stimulation of FGF21 production, a known insulin sensitizer.	Curcumin	75-83	fibroblast growth factor 21	Mus musculus	199-204
26338887-13	2015	CONCLUSION: These observations suggest that the early beneficial effect of curcumin intervention in dexamethasone-treated mice is the sensitization of insulin signaling, involving the stimulation of FGF21 production, a known insulin sensitizer.	Dexamethasone	100-113	fibroblast growth factor 21	Mus musculus	199-204
25733154-0	2015	Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.	Fatty Acids	117-128	fibroblast growth factor 21	Mus musculus	40-45
26203166-4	2015	Here, we report that FGF21 KO mice have hepatic insulin resistance and increased hepatic glucose production associated with an increase in plasma glucagon levels.	Glucagon	146-154	fibroblast growth factor 21	Mus musculus	21-26
26757545-7	2015	Average blood glucose, insulin, blood lipid and inflammatory factor of FGF-21 treatment group compared with type 2 diabetes group was significantly lower (P < 0.01) and insulin group has no difference with the model control group.	Blood Glucose	8-21	fibroblast growth factor 21	Mus musculus	71-77
25557015-6	2015	We noticed that both PEGylated FGF-21 and liraglutide could significantly decrease plasma glucose in db/db mice.	Glucose	90-97	fibroblast growth factor 21	Mus musculus	31-37
25557015-7	2015	However, comparing to liraglutide treatments, PEGylated FGF-21 therapy resulted in more significant effect in lowering blood glucose levels and glycosylated hemoglobin levels, alleviating insulin resistance, improving lipid profile, liver function, and glucose control of the experimental mice.	Glucose	125-132	fibroblast growth factor 21	Mus musculus	56-62
25557015-7	2015	However, comparing to liraglutide treatments, PEGylated FGF-21 therapy resulted in more significant effect in lowering blood glucose levels and glycosylated hemoglobin levels, alleviating insulin resistance, improving lipid profile, liver function, and glucose control of the experimental mice.	Glucose	253-260	fibroblast growth factor 21	Mus musculus	56-62
26187667-0	2015	Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKA(y) mice.	Eicosapentaenoic Acid	13-34	fibroblast growth factor 21	Mus musculus	84-111
26187667-1	2015	Fibroblast growth factor (FGF) 21 is a mediator of glucose and lipid metabolism.	Glucose	51-58	fibroblast growth factor 21	Mus musculus	0-33
26187667-2	2015	Although exogenous administration of FGF21 exerts beneficial effects on glucose and lipid metabolism, circulating FGF21 levels are elevated in ob/ob and db/db mice, diet-induced obese mice and obese human.	Glucose	72-79	fibroblast growth factor 21	Mus musculus	37-42
26187667-3	2015	Here we show that ingestion of eicosapentaenoic acid (EPA) for 6 days after individually-housing significantly suppressed the hyperglycemia and hypertriglyceridemia associated with decreases in plasma insulin and FGF21 levels in KKA(y) mice while having no effects on food intake, body weight or plasma active GLP-1 levels.	Eicosapentaenoic Acid	31-52	fibroblast growth factor 21	Mus musculus	213-218
26187667-3	2015	Here we show that ingestion of eicosapentaenoic acid (EPA) for 6 days after individually-housing significantly suppressed the hyperglycemia and hypertriglyceridemia associated with decreases in plasma insulin and FGF21 levels in KKA(y) mice while having no effects on food intake, body weight or plasma active GLP-1 levels.	Eicosapentaenoic Acid	54-57	fibroblast growth factor 21	Mus musculus	213-218
26187667-7	2015	These findings suggest that EPA ingestion in the early stage of social isolation suppresses hyperglycemia and hypertriglyceridemia associated with reduced FGF21 and insulin resistance without altering food intake and body weight, and that the EPA ingestion suppresses hepatic lipogenesis by suppressing Notch- and gp78-independent SEREBP1c and ChREBP pathways in KKA(y) mice.	Eicosapentaenoic Acid	28-31	fibroblast growth factor 21	Mus musculus	155-160
26040473-6	2015	FGF21 significantly reduced palmitate-induced cardiac apoptosis.	Palmitates	28-37	fibroblast growth factor 21	Mus musculus	0-5
26040473-8	2015	Inhibition of each kinase with its inhibitor and/or siRNA revealed that FGF21 prevents palmitate-induced cardiac apoptosis via upregulating the ERK1/2-dependent p38 MAPK-AMPK signalling pathway.	Palmitates	87-96	fibroblast growth factor 21	Mus musculus	72-77
26040473-9	2015	In vivo administration of FGF21, but not FGF21 plus ERK1/2 inhibitor, to diabetic or fatty-acid-infused mice significantly prevented cardiac apoptosis and reduced inactivation of ERK1/2, p38 MAPK and AMPK and prevented cardiac remodelling and dysfunction.	Fatty Acids	85-95	fibroblast growth factor 21	Mus musculus	26-31
26061387-9	2015	Mechanistically, DHI induced expression of glucokinase, AMPKalpha/phosphorylated AMPKalpha, insulin receptor substrate 1, fibroblast growth factor 21 and peroxisome proliferator-activated gamma.	dehydrosoyasaponin I	17-20	fibroblast growth factor 21	Mus musculus	122-149
26153793-6	2015	Upon excision of iBAT (X-BAT) and administration of FGF21 to mice housed at 80  F or 72  F, the favorable effects of FGF21 on BW and glucose excursion were fully retained in both sham and X-BAT animals.	Glucose	133-140	fibroblast growth factor 21	Mus musculus	52-57
26153793-6	2015	Upon excision of iBAT (X-BAT) and administration of FGF21 to mice housed at 80  F or 72  F, the favorable effects of FGF21 on BW and glucose excursion were fully retained in both sham and X-BAT animals.	Glucose	133-140	fibroblast growth factor 21	Mus musculus	117-122
25736301-0	2015	Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.	Methionine	74-84	fibroblast growth factor 21	Mus musculus	8-35
25736301-0	2015	Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.	Choline	90-97	fibroblast growth factor 21	Mus musculus	8-35
25736301-3	2015	C57BL/6J Fgf21-null and wild-type mice were treated with MCD for 1 week.	mcd	57-60	fibroblast growth factor 21	Mus musculus	9-14
25736301-7	2015	Exposure of primary hepatocytes to palmitic acid elevated the mRNA levels encoding DNA damage-inducible transcript 3, an indicator of ER stress, and FGF21 in a PPARalpha-independent manner, suggesting that lipid-induced ER stress can enhance hepatic FGF21 expression.	Palmitic Acid	35-48	fibroblast growth factor 21	Mus musculus	149-154
25736301-7	2015	Exposure of primary hepatocytes to palmitic acid elevated the mRNA levels encoding DNA damage-inducible transcript 3, an indicator of ER stress, and FGF21 in a PPARalpha-independent manner, suggesting that lipid-induced ER stress can enhance hepatic FGF21 expression.	Palmitic Acid	35-48	fibroblast growth factor 21	Mus musculus	250-255
26092866-0	2015	FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice.	Alcohols	15-22	fibroblast growth factor 21	Mus musculus	0-5
26092866-0	2015	FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice.	Catecholamines	93-106	fibroblast growth factor 21	Mus musculus	0-5
26092866-2	2015	This study aimed to investigate the role of fibroblast growth factor (FGF)21, a metabolic regulator, in the regulation of chronic-binge alcohol-induced adipose tissue lipolysis.	Alcohols	136-143	fibroblast growth factor 21	Mus musculus	70-76
26092866-3	2015	FGF21 KO mice were subjected to chronic-binge alcohol exposure, and epididymal white adipose tissue lipolysis and liver steatosis were investigated.	Alcohols	46-53	fibroblast growth factor 21	Mus musculus	0-5
26092866-4	2015	Alcohol exposure caused adipose intracellular cAMP elevation and activation of lipolytic enzymes, leading to FFA mobilization in both WT and FGF21 KO mice.	Alcohols	0-7	fibroblast growth factor 21	Mus musculus	141-146
26092866-8	2015	Taken together, our studies demonstrate that FGF21 KO mice are protected from alcohol-induced adipose tissue excess-lipolysis through a mechanism involving systemic catecholamine release.	Alcohols	78-85	fibroblast growth factor 21	Mus musculus	45-50
26092866-8	2015	Taken together, our studies demonstrate that FGF21 KO mice are protected from alcohol-induced adipose tissue excess-lipolysis through a mechanism involving systemic catecholamine release.	Catecholamines	165-178	fibroblast growth factor 21	Mus musculus	45-50
25924103-4	2015	We administered FGF21 into the central nervous system via lateral ventricle infusion into male mice and found that the central treatment increased norepinephrine turnover in target tissues that include the inguinal white adipose tissue and brown adipose tissue.	Norepinephrine	147-161	fibroblast growth factor 21	Mus musculus	16-21
27391008-1	2015	Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes.	Glucose	65-72	fibroblast growth factor 21	Mus musculus	0-27
27391008-1	2015	Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes.	Glucose	65-72	fibroblast growth factor 21	Mus musculus	29-34
27391008-6	2015	Further investigation found that FGF21 deletion exacerbated aortic inflammation and oxidative stress reflected by elevated expression of tumor necrosis factor alpha and transforming growth factor beta, and the accumulation of 3-nitrotyrocine and 4-Hydroxynonenal.	3-nitrotyrocine	226-241	fibroblast growth factor 21	Mus musculus	33-38
27391008-6	2015	Further investigation found that FGF21 deletion exacerbated aortic inflammation and oxidative stress reflected by elevated expression of tumor necrosis factor alpha and transforming growth factor beta, and the accumulation of 3-nitrotyrocine and 4-Hydroxynonenal.	4-hydroxy-2-nonenal	246-262	fibroblast growth factor 21	Mus musculus	33-38
25306889-0	2015	Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats.	Sodium Glutamate	91-111	fibroblast growth factor 21	Mus musculus	19-46
25794851-1	2015	BACKGROUND: Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity.	Glucose	99-106	fibroblast growth factor 21	Mus musculus	12-39
25794851-1	2015	BACKGROUND: Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity.	Glucose	99-106	fibroblast growth factor 21	Mus musculus	41-46
25794851-6	2015	Replenishment of FGF21 protects against atherosclerosis in apolipoprotein E(-/-)mice via 2 independent mechanisms, inducing the adipocyte production of adiponectin, which in turn acts on the blood vessels to inhibit neointima formation and macrophage inflammation, and suppressing the hepatic expression of the transcription factor sterol regulatory element-binding protein-2, thereby leading to reduced cholesterol synthesis and attenuation of hypercholesterolemia.	Cholesterol	404-415	fibroblast growth factor 21	Mus musculus	17-22
25794851-8	2015	By contrast, the cholesterol-lowering effects of FGF21 are abrogated by hepatic expression of sterol regulatory element-binding protein-2.	Cholesterol	17-28	fibroblast growth factor 21	Mus musculus	49-54
25774553-4	2015	Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin"s mechanism of action.	naringenin	8-18	fibroblast growth factor 21	Mus musculus	100-105
25774553-4	2015	Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin"s mechanism of action.	naringenin	135-145	fibroblast growth factor 21	Mus musculus	100-105
25774553-5	2015	Furthermore, we predicted that FGF21 deficiency would potentiate high-fat diet (HFD)-induced metabolic dysregulation and compromise metabolic protection by naringenin.	naringenin	156-166	fibroblast growth factor 21	Mus musculus	31-36
25774553-9	2015	Naringenin corrected hepatic triglyceride concentrations and normalized hepatic expression of Pgc1a, Cpt1a, and Srebf1c in both wild-type and Fgf21(-/-) mice.	naringenin	0-10	fibroblast growth factor 21	Mus musculus	142-147
25871519-0	2015	Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation.	Galactose	57-68	fibroblast growth factor 21	Mus musculus	0-27
25871519-4	2015	In this study d-galactose (d-gal)-induced aging mice were used to study the mechanism that FGF21 protects mice from aging.	Galactose	14-25	fibroblast growth factor 21	Mus musculus	91-96
25871519-4	2015	In this study d-galactose (d-gal)-induced aging mice were used to study the mechanism that FGF21 protects mice from aging.	Galactose	14-19	fibroblast growth factor 21	Mus musculus	91-96
25871519-6	2015	Our results showed that administration of FGF21 significantly improved behavioral performance of d-gal-treated mice in water maze task and step-down test, reduced brain cell damage in the hippocampus, and attenuated the d-gal-induced production of MDA, ROS and advanced glycation end products (AGEs).	ros	253-256	fibroblast growth factor 21	Mus musculus	42-47
25538153-5	2015	In keeping with this, expression of antioxidant genes in response to lipopolysaccharide (LPS)-induced stimulation of pro-inflammatory pathways or isoproterenol-induced cardiac hypertrophy in the heart was reduced in Fgf21-null mice.	Isoproterenol	146-159	fibroblast growth factor 21	Mus musculus	216-221
25701356-0	2015	Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways.	Galactose	62-73	fibroblast growth factor 21	Mus musculus	26-31
25701356-1	2015	FGF21 is recently discovered with pleiotropic effects on glucose and lipid metabolism.	Glucose	57-64	fibroblast growth factor 21	Mus musculus	0-5
25701356-6	2015	FGF21 treatment also suppressed D-gal-induced profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level in the liver, and restored the activities of antioxidant enzymes SOD, CAT, GSH-Px, and T-AOC.	ros	68-71	fibroblast growth factor 21	Mus musculus	0-5
25701356-6	2015	FGF21 treatment also suppressed D-gal-induced profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level in the liver, and restored the activities of antioxidant enzymes SOD, CAT, GSH-Px, and T-AOC.	Glutathione	185-188	fibroblast growth factor 21	Mus musculus	0-5
25701356-6	2015	FGF21 treatment also suppressed D-gal-induced profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level in the liver, and restored the activities of antioxidant enzymes SOD, CAT, GSH-Px, and T-AOC.	gsh-px	270-276	fibroblast growth factor 21	Mus musculus	0-5
25701356-8	2015	Furthermore, a TUNEL assay showed that D-gal-induced apoptosis in the mouse liver was significantly inhibited by FGF21.	Galactose	39-44	fibroblast growth factor 21	Mus musculus	113-118
25701356-9	2015	The expression of caspase-3 was markedly inhibited by the treatment of FGF21 in the liver of D-gal-treated mice.	Galactose	93-98	fibroblast growth factor 21	Mus musculus	71-76
25560828-3	2015	Western blottings revealed that protein kinase B (AKT)-mediated glucose signaling was down-regulated in diabetic testes and further decreased in FGF21-KO diabetic group both 10 days and 2 months after diabetes onset, reflected by reduced glycogen synthase (GS) kinase (GSK)-3beta phosphorylation and increased GS phosphorylation.	Glucose	64-71	fibroblast growth factor 21	Mus musculus	145-150
25537833-8	2015	Fgf21-null mice exhibited increased expression of ER stress marker genes and augmented hepatic lipid accumulation after tunicamycin treatment.	Tunicamycin	120-131	fibroblast growth factor 21	Mus musculus	0-5
25827749-6	2015	We demonstrate that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 (FGF21) and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues.	Alanine	54-61	fibroblast growth factor 21	Mus musculus	107-134
25827749-6	2015	We demonstrate that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 (FGF21) and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues.	Alanine	54-61	fibroblast growth factor 21	Mus musculus	136-141
25790234-9	2015	Our data show that the intact N-terminus of FGF21 in PF-05231023 appears to be sufficient to drive glucose lowering during OGTT and sustain BW loss in DIOs.	Glucose	99-106	fibroblast growth factor 21	Mus musculus	44-49
25560828-4	2015	Deletion of the Fgf21 gene also inactivated fatty acid metabolism-related factors, AMP-activated protein kinase (AMPK), sirtuin 1 (Sirt1), and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), along with exacerbating diabetes-induced testicular oxidative stress and damage.	Fatty Acids	44-54	fibroblast growth factor 21	Mus musculus	16-21
25601498-10	2015	Furthermore, FGF21 inhibited IkappaBalpha degradation and NF-kappaB p65 nuclear translocation and induced significant changes of oxidative stress parameters (MDA, SOD, CAT, GSH-PX and GSH) in the plasma.	gsh-px	173-179	fibroblast growth factor 21	Mus musculus	13-18
25601498-10	2015	Furthermore, FGF21 inhibited IkappaBalpha degradation and NF-kappaB p65 nuclear translocation and induced significant changes of oxidative stress parameters (MDA, SOD, CAT, GSH-PX and GSH) in the plasma.	Glutathione	173-176	fibroblast growth factor 21	Mus musculus	13-18
25359298-0	2015	Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function.	Glucose	60-67	fibroblast growth factor 21	Mus musculus	0-27
25501997-1	2015	Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a peptide hormone that is usually induced by fasting and that influences lipid and carbohydrate metabolism via local hepatic and systemic endocrine effects.	Carbohydrates	235-247	fibroblast growth factor 21	Mus musculus	115-142
25501997-1	2015	Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a peptide hormone that is usually induced by fasting and that influences lipid and carbohydrate metabolism via local hepatic and systemic endocrine effects.	Carbohydrates	235-247	fibroblast growth factor 21	Mus musculus	144-149
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	27-43	fibroblast growth factor 21	Mus musculus	101-106
25501997-4	2015	We confirm that active TH (triiodothyronine (T3)) and the TRbeta-selective thyromimetic GC1 increase FGF21 transcript and peptide levels in mouse liver and that this effect requires TRbeta.	Triiodothyronine	45-47	fibroblast growth factor 21	Mus musculus	101-106
25359298-0	2015	Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function.	Streptozocin	71-85	fibroblast growth factor 21	Mus musculus	0-27
25451186-4	2015	RESULTS: Both PEGylated FGF-21 and insulin glargine decreased plasma glucose in db/db mice.	Glucose	69-76	fibroblast growth factor 21	Mus musculus	24-30
25359298-5	2015	RESULTS: The STZ mice had elevated blood glucose and reduced plasma FGF21 levels, impaired glucose uptake in the BAT, and BAT mitochondria with absent or swollen cristae and fewer lipid vacuoles.	Streptozocin	13-16	fibroblast growth factor 21	Mus musculus	68-73
25451186-5	2015	However, compared with insulin glargine treatment, PEGylated FGF-21 therapy had more significant effects in lowering blood glucose and glycosylated haemoglobin levels, improving lipid profile and liver function parameters, alleviating insulin resistance and reducing the glucose area under the curve in OGTTs.	Glucose	123-130	fibroblast growth factor 21	Mus musculus	61-67
25451186-5	2015	However, compared with insulin glargine treatment, PEGylated FGF-21 therapy had more significant effects in lowering blood glucose and glycosylated haemoglobin levels, improving lipid profile and liver function parameters, alleviating insulin resistance and reducing the glucose area under the curve in OGTTs.	Glucose	271-278	fibroblast growth factor 21	Mus musculus	61-67
26133178-4	2015	During fasting, increased expression of FGF21 induces gluconeogenesis, fatty acid oxidation, and ketogenesis: as a result, FGF21 is considered a key regulator of the metabolic adaptation to fasting.	Fatty Acids	71-81	fibroblast growth factor 21	Mus musculus	40-45
25495872-3	2015	It was previously shown that FGF21 induces corticosterone levels in mice by acting on the brain.	Corticosterone	43-57	fibroblast growth factor 21	Mus musculus	29-34
25495872-5	2015	FGF21 also increases corticosterone secretion from the adrenal in response to ACTH.	Corticosterone	21-35	fibroblast growth factor 21	Mus musculus	0-5
25685364-4	2015	In mice, lifetime acarbose feeding can increase median and maximal lifespan-an effect associated with increased plasma levels of fibroblast growth factor 21 (FGF21) and decreased levels of insulin-like growth factor-I (IGF-I).	Acarbose	18-26	fibroblast growth factor 21	Mus musculus	129-156
25685364-4	2015	In mice, lifetime acarbose feeding can increase median and maximal lifespan-an effect associated with increased plasma levels of fibroblast growth factor 21 (FGF21) and decreased levels of insulin-like growth factor-I (IGF-I).	Acarbose	18-26	fibroblast growth factor 21	Mus musculus	158-163
26133178-4	2015	During fasting, increased expression of FGF21 induces gluconeogenesis, fatty acid oxidation, and ketogenesis: as a result, FGF21 is considered a key regulator of the metabolic adaptation to fasting.	Fatty Acids	71-81	fibroblast growth factor 21	Mus musculus	123-128
25024372-6	2014	FGF21 acts directly on the hypothalamic neurons to activate the mitogen-activated protein kinase extracellular signal-related kinase 1/2 (ERK1/2), thereby stimulating the expression of corticotropin-releasing hormone by activation of the transcription factor cAMP response element binding protein.	Cyclic AMP	259-263	fibroblast growth factor 21	Mus musculus	0-5
25991671-0	2015	Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARalpha(PAC) mice due to dysregulated bile acid synthesis.	Bile Acids and Salts	149-158	fibroblast growth factor 21	Mus musculus	21-48
26089880-1	2015	Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight.	Glucose	97-104	fibroblast growth factor 21	Mus musculus	0-27
26089880-1	2015	Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight.	Glucose	97-104	fibroblast growth factor 21	Mus musculus	29-34
26089880-5	2015	Since FGF21 is believed to exert its effects mostly at the transcriptional level, we analyzed and observed significant upregulation in expression of various genes involved in carbohydrate and lipid metabolism, energy homeostasis, and antioxidant defense in FGF21-treated controls, but not in GH transgenics.	Carbohydrates	175-187	fibroblast growth factor 21	Mus musculus	6-11
26089880-5	2015	Since FGF21 is believed to exert its effects mostly at the transcriptional level, we analyzed and observed significant upregulation in expression of various genes involved in carbohydrate and lipid metabolism, energy homeostasis, and antioxidant defense in FGF21-treated controls, but not in GH transgenics.	Carbohydrates	175-187	fibroblast growth factor 21	Mus musculus	257-262
25456819-1	2015	OBJECTIVE: In this study, we compared the long-acting hypoglycemic effect of PEGylated FGF21 (PEG-FGF21) with insulin glargine in mice with STZ-induced type 1 diabetes.	Streptozocin	140-143	fibroblast growth factor 21	Mus musculus	87-92
25456819-1	2015	OBJECTIVE: In this study, we compared the long-acting hypoglycemic effect of PEGylated FGF21 (PEG-FGF21) with insulin glargine in mice with STZ-induced type 1 diabetes.	Streptozocin	140-143	fibroblast growth factor 21	Mus musculus	98-103
25456819-5	2015	However, mice treated with PEG-FGF21 had lower blood glucose levels of 8.0 to 9.0mmol/L on day 10 and maintained this level until the end of the experiment.	Polyethylene Glycols	27-30	fibroblast growth factor 21	Mus musculus	31-36
25456819-5	2015	However, mice treated with PEG-FGF21 had lower blood glucose levels of 8.0 to 9.0mmol/L on day 10 and maintained this level until the end of the experiment.	Glucose	53-60	fibroblast growth factor 21	Mus musculus	31-36
25456819-9	2015	PEG-FGF21 achieves glucose clearance by accelerating glycolysis by up-regulating expression of GK and GLUT1 and inhibiting gluconeogenesis via down-regulation of G6Pase and PEPCK expression.	Glucose	19-26	fibroblast growth factor 21	Mus musculus	4-9
25449271-0	2014	Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH.	Thioctic Acid	0-17	fibroblast growth factor 21	Mus musculus	34-61
25449271-3	2014	Here, we investigated the effect of ALA on hepatic FGF21 expression.	Thioctic Acid	36-39	fibroblast growth factor 21	Mus musculus	51-56
25449271-4	2014	ALA treatment enhanced CREBH and FGF21 mRNA expression and protein abundance in cultured hepatocytes.	Thioctic Acid	0-3	fibroblast growth factor 21	Mus musculus	33-38
25449271-5	2014	ALA increased FGF21 promoter activity by up-regulating CREBH expression and increasing CREBH binding to the FGF21 promoter, indicating that ALA up-regulates FGF21 at the transcriptional level.	Thioctic Acid	0-3	fibroblast growth factor 21	Mus musculus	14-19
25449271-5	2014	ALA increased FGF21 promoter activity by up-regulating CREBH expression and increasing CREBH binding to the FGF21 promoter, indicating that ALA up-regulates FGF21 at the transcriptional level.	Thioctic Acid	0-3	fibroblast growth factor 21	Mus musculus	108-113
25449271-5	2014	ALA increased FGF21 promoter activity by up-regulating CREBH expression and increasing CREBH binding to the FGF21 promoter, indicating that ALA up-regulates FGF21 at the transcriptional level.	Thioctic Acid	0-3	fibroblast growth factor 21	Mus musculus	108-113
25449271-6	2014	Moreover, inhibition of endogenous CREBH expression by siRNA attenuated ALA-induced FGF21 expression.	Thioctic Acid	72-75	fibroblast growth factor 21	Mus musculus	84-89
25449271-7	2014	Finally, treatment of mice with ALA enhanced fasting-induced up-regulation of CREBH and FGF21 in the liver and inhibited feeding-induced suppression of their expression.	Thioctic Acid	32-35	fibroblast growth factor 21	Mus musculus	88-93
25449271-8	2014	Consistently, ALA increased serum FGF21 levels in both fasted and fed mice.	Thioctic Acid	14-17	fibroblast growth factor 21	Mus musculus	34-39
25449271-9	2014	Collectively, these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21.	Thioctic Acid	42-45	fibroblast growth factor 21	Mus musculus	64-69
25449271-9	2014	Collectively, these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21.	Thioctic Acid	42-45	fibroblast growth factor 21	Mus musculus	158-163
25449271-9	2014	Collectively, these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21.	Thioctic Acid	121-124	fibroblast growth factor 21	Mus musculus	64-69
25449271-9	2014	Collectively, these results indicate that ALA increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21.	Thioctic Acid	121-124	fibroblast growth factor 21	Mus musculus	158-163
25355486-3	2014	In this paper, we tested the effect of FGF21 on alcohol-induced liver injury in a murine model of chronic ethanol gavage and alcohol-treated HepG2 cells.	Alcohols	48-55	fibroblast growth factor 21	Mus musculus	39-44
25355486-6	2014	Results showed that treatment with recombinant FGF21 ameliorated alcoholic fatty liver and liver injury both in a murine model of chronic ethanol gavage and alcohol-treated HepG2 cells.	Ethanol	138-145	fibroblast growth factor 21	Mus musculus	47-52
25355486-6	2014	Results showed that treatment with recombinant FGF21 ameliorated alcoholic fatty liver and liver injury both in a murine model of chronic ethanol gavage and alcohol-treated HepG2 cells.	Alcohols	65-72	fibroblast growth factor 21	Mus musculus	47-52
25008183-0	2014	Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.	Glucose	48-55	fibroblast growth factor 21	Mus musculus	12-17
25008183-5	2014	After a prolonged fast, FGF21 acts as an insulin sensitizer to overcome the peripheral insulin resistance induced by fasting, thereby maximizing glucose uptake.	Glucose	145-152	fibroblast growth factor 21	Mus musculus	24-29
25008183-7	2014	DIO FGF21 liver-specific knockout, but not FGF21 adipose-specific knockout, mice have increased insulin resistance and decreased brown adipose tissue-mediated glucose disposal.	Glucose	159-166	fibroblast growth factor 21	Mus musculus	4-9
25024372-0	2014	FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.	Glucose	16-23	fibroblast growth factor 21	Mus musculus	0-5
25024372-3	2014	Prolonged fasting induces activation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) in the liver and subsequent hepatic production of FGF21, which enters into the brain to activate the hypothalamic-pituitary-adrenal (HPA) axis for release of corticosterone, thereby stimulating hepatic gluconeogenesis.	Corticosterone	284-298	fibroblast growth factor 21	Mus musculus	176-181
25024372-4	2014	Fasted FGF21 knockout (KO) mice exhibit severe hypoglycemia and defective hepatic gluconeogenesis due to impaired activation of the HPA axis and blunted release of corticosterone, a phenotype similar to that observed in PPARalpha KO mice.	Corticosterone	164-178	fibroblast growth factor 21	Mus musculus	7-12
25024372-5	2014	By contrast, intracerebroventricular injection of FGF21 reverses fasting hypoglycemia and impairment in hepatic gluconeogenesis by restoring corticosterone production in both FGF21 KO and PPARalpha KO mice, whereas all these central effects of FGF21 were abrogated by blockage of hypothalamic FGF receptor-1.	Corticosterone	141-155	fibroblast growth factor 21	Mus musculus	50-55
25024372-7	2014	Therefore, FGF21 maintains glucose homeostasis during prolonged fasting by fine tuning the interorgan cross talk between liver and brain.	Glucose	27-34	fibroblast growth factor 21	Mus musculus	11-16
25270507-3	2014	FGF21 (fibroblast growth factor 21) is known as a key mediator of glucose and lipid metabolism.	Glucose	66-73	fibroblast growth factor 21	Mus musculus	0-5
25270507-3	2014	FGF21 (fibroblast growth factor 21) is known as a key mediator of glucose and lipid metabolism.	Glucose	66-73	fibroblast growth factor 21	Mus musculus	7-34
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	18-25	fibroblast growth factor 21	Mus musculus	155-160
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	18-25	fibroblast growth factor 21	Mus musculus	179-184
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	dien-28-oyl] imidazole	87-109	fibroblast growth factor 21	Mus musculus	155-160
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	18-25	fibroblast growth factor 21	Mus musculus	242-247
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	dien-28-oyl] imidazole	87-109	fibroblast growth factor 21	Mus musculus	179-184
25170079-5	2014	Intraperitoneal administration of the ER stressor tunicamycin in mice resulted in hepatic steatosis, accompanied by activation of the three canonical UPR branches and increased the expression of FGF21.	Tunicamycin	50-61	fibroblast growth factor 21	Mus musculus	195-200
25270507-6	2014	Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background.	dien-28-oyl] imidazole	87-109	fibroblast growth factor 21	Mus musculus	242-247
25083607-8	2014	FGF21-KO mice had reduced hepatic fatty acid activation and beta-oxidation, resulting in increased levels of free fatty acid.	Fatty Acids	34-44	fibroblast growth factor 21	Mus musculus	0-5
25083607-8	2014	FGF21-KO mice had reduced hepatic fatty acid activation and beta-oxidation, resulting in increased levels of free fatty acid.	Fatty Acids, Nonesterified	109-124	fibroblast growth factor 21	Mus musculus	0-5
25083607-11	2014	CONCLUSIONS: FGF21 regulates fatty acid activation and oxidation in livers of mice.	Fatty Acids	29-39	fibroblast growth factor 21	Mus musculus	13-18
25369265-9	2014	However, compared to AL-fed WT mice, AL-fed FGF21-knockout mice exhibited higher basal rates of cell proliferation, suggesting anti-mitotic effects of FGF21.	Aluminum	37-39	fibroblast growth factor 21	Mus musculus	44-49
25369265-9	2014	However, compared to AL-fed WT mice, AL-fed FGF21-knockout mice exhibited higher basal rates of cell proliferation, suggesting anti-mitotic effects of FGF21.	Aluminum	37-39	fibroblast growth factor 21	Mus musculus	151-156
25083607-0	2014	Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.	Fatty Acids	69-79	fibroblast growth factor 21	Mus musculus	0-27
25083607-0	2014	Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.	Methionine	102-112	fibroblast growth factor 21	Mus musculus	0-27
25170079-7	2014	Administration of recombinant FGF21 in mice alleviated tunicamycin-induced liver steatosis, in parallel with reduced eIF2alpha-ATF4-CHOP signaling.	Tunicamycin	55-66	fibroblast growth factor 21	Mus musculus	30-35
24914939-3	2014	Fibroblast growth factor 21 (FGF-21) may function as an endocrine factor to regulate body composition changes during lactation by inducing gluconeogenesis and fatty acid oxidation.	Fatty Acids	159-169	fibroblast growth factor 21	Mus musculus	0-27
24949663-9	2014	Administration of glucagon restored the expression of Ucp1 mRNA in the BAT as well as the expression of the fibroblast growth factor 21 gene (Fgf21) in the liver.	Glucagon	18-26	fibroblast growth factor 21	Mus musculus	108-135
24949663-9	2014	Administration of glucagon restored the expression of Ucp1 mRNA in the BAT as well as the expression of the fibroblast growth factor 21 gene (Fgf21) in the liver.	Glucagon	18-26	fibroblast growth factor 21	Mus musculus	142-147
24949663-10	2014	Supplementation with glucagon for 2 weeks resulted in higher plasma Fgf21 levels and improved responses to CL-316,243 in GCGKO mice.	Glucagon	21-29	fibroblast growth factor 21	Mus musculus	68-73
24949663-11	2014	These results indicated that endogenous glucagon is essential for adaptive thermogenesis and that it regulates BAT function, most likely by increasing hepatic Fgf21 production.	Glucagon	40-48	fibroblast growth factor 21	Mus musculus	159-164
24914939-3	2014	Fibroblast growth factor 21 (FGF-21) may function as an endocrine factor to regulate body composition changes during lactation by inducing gluconeogenesis and fatty acid oxidation.	Fatty Acids	159-169	fibroblast growth factor 21	Mus musculus	29-35
24732703-6	2014	Also uncoupling induced induction and secretion of fibroblast growth factor 21 (FGF21) from SM was preserved in DTG mice.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	112-115	fibroblast growth factor 21	Mus musculus	51-78
24590984-0	2014	Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice.	Acetaminophen	45-58	fibroblast growth factor 21	Mus musculus	0-27
24590984-2	2014	Fibroblast growth factor 21 (FGF21) is a hepatocyte-secreted hormone with pleiotropic effects on glucose and lipid metabolism.	Glucose	97-104	fibroblast growth factor 21	Mus musculus	0-27
24590984-2	2014	Fibroblast growth factor 21 (FGF21) is a hepatocyte-secreted hormone with pleiotropic effects on glucose and lipid metabolism.	Glucose	97-104	fibroblast growth factor 21	Mus musculus	29-34
24590984-4	2014	In response to APAP overdose, both hepatic expression and circulating levels of FGF21 in mice were dramatically increased as early as 3 hours, prior to elevations of the liver injury markers alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Acetaminophen	15-19	fibroblast growth factor 21	Mus musculus	80-85
24590984-5	2014	APAP overdose-induced liver damage and mortality in FGF21 knockout (KO) mice were markedly aggravated, which was accompanied by increased oxidative stress and impaired antioxidant capacities as compared to wild-type (WT) littermates.	Acetaminophen	0-4	fibroblast growth factor 21	Mus musculus	52-57
24590984-8	2014	The beneficial effects of recombinant FGF21 on up-regulation of Nrf2 and antioxidant genes and alleviation of APAP-induced oxidative stress and liver injury were largely abolished by adenovirus-mediated knockdown of hepatic PGC-1alpha expression, whereas overexpression of PGC-1alpha was sufficient to counteract the increased susceptibility of FGF21 KO mice to APAP-induced hepatotoxicity.	Acetaminophen	110-114	fibroblast growth factor 21	Mus musculus	38-43
24747761-1	2014	FGF21 is a secreted protein that plays critical roles in regulating glucose and lipid metabolism.	Glucose	68-75	fibroblast growth factor 21	Mus musculus	0-5
24747761-6	2014	Mechanistic studies on the effects of FGF21 gene transfer in lean mice revealed that mice transferred with FGF21 gene displayed suppressed lipogenesis in the liver and enhanced thermogenesis in brown adipose tissue which was coincident with a significant improvement in glucose tolerance.	Glucose	270-277	fibroblast growth factor 21	Mus musculus	107-112
24769090-9	2014	This indicates that TCDD-induced Fgf21 expression protects against TCDD toxicity.	Polychlorinated Dibenzodioxins	20-24	fibroblast growth factor 21	Mus musculus	33-38
24769090-10	2014	Diethylhexylphthalate (DEHP) pretreatment attenuated TCDD-induced Fgf21 expression in mouse liver and white adipose tissue, which may explain a previous report that DEHP pretreatment decreases TCDD-induced wasting.	Diethylhexyl Phthalate	0-21	fibroblast growth factor 21	Mus musculus	66-71
24769090-10	2014	Diethylhexylphthalate (DEHP) pretreatment attenuated TCDD-induced Fgf21 expression in mouse liver and white adipose tissue, which may explain a previous report that DEHP pretreatment decreases TCDD-induced wasting.	Diethylhexyl Phthalate	23-27	fibroblast growth factor 21	Mus musculus	66-71
24769090-10	2014	Diethylhexylphthalate (DEHP) pretreatment attenuated TCDD-induced Fgf21 expression in mouse liver and white adipose tissue, which may explain a previous report that DEHP pretreatment decreases TCDD-induced wasting.	Polychlorinated Dibenzodioxins	53-57	fibroblast growth factor 21	Mus musculus	66-71
24769090-10	2014	Diethylhexylphthalate (DEHP) pretreatment attenuated TCDD-induced Fgf21 expression in mouse liver and white adipose tissue, which may explain a previous report that DEHP pretreatment decreases TCDD-induced wasting.	Polychlorinated Dibenzodioxins	193-197	fibroblast growth factor 21	Mus musculus	66-71
24593051-5	2014	Using this mouse model, we determined the effects of FGF-21 knockdown in vivo on hepatic glucose production, gluconeogenesis and glycogenolysis, and their relationship with the signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 3 (SOCS3) signal pathways.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	53-59
24898837-7	2014	The increased FGF21 production at P18 was dissociated from plasma nonesterified fatty acids and liver lipids, unlike that seen in fasted V mice.	nonesterified	66-79	fibroblast growth factor 21	Mus musculus	14-19
24898837-7	2014	The increased FGF21 production at P18 was dissociated from plasma nonesterified fatty acids and liver lipids, unlike that seen in fasted V mice.	Fatty Acids	80-91	fibroblast growth factor 21	Mus musculus	14-19
24769090-4	2014	In mouse liver, TCDD increased Fgf21 mRNA in both dose- and time-dependent manners.	Polychlorinated Dibenzodioxins	16-20	fibroblast growth factor 21	Mus musculus	31-36
24769090-5	2014	In addition, TCDD markedly increased Fgf21 mRNA expression in cultured mouse and human hepatocytes.	Polychlorinated Dibenzodioxins	13-17	fibroblast growth factor 21	Mus musculus	37-42
24769090-6	2014	Moreover, TCDD increased mRNA (in liver) and protein levels (in both liver and serum) of Fgf21 in wild-type mice, but not in AhR-null mice.	Polychlorinated Dibenzodioxins	10-14	fibroblast growth factor 21	Mus musculus	89-94
24769090-7	2014	Chromatin immunoprecipitation assays showed that TCDD increased AhR protein binding to the Fgf21 promoter (-105/+1 base pair).	Polychlorinated Dibenzodioxins	49-53	fibroblast growth factor 21	Mus musculus	91-96
24769090-8	2014	Fgf21-null mice administered 200mug/kg of TCDD died within 20days, whereas wild-type mice receiving the same treatment were still alive at one month after administration.	Polychlorinated Dibenzodioxins	42-46	fibroblast growth factor 21	Mus musculus	0-5
25233630-0	2014	[Effect of FGF-21 on learning and memory ability and antioxidant capacity in brain tissue of D-galactose-induced aging mice].	Galactose	93-104	fibroblast growth factor 21	Mus musculus	11-17
25233630-1	2014	This study aims to investigate the effects of fibroblast growth factor 21 (FGF-21) on learning and memory abilities and antioxidant capacity of D-galactose-induced aging mice.	Galactose	144-155	fibroblast growth factor 21	Mus musculus	46-73
25233630-1	2014	This study aims to investigate the effects of fibroblast growth factor 21 (FGF-21) on learning and memory abilities and antioxidant capacity of D-galactose-induced aging mice.	Galactose	144-155	fibroblast growth factor 21	Mus musculus	75-81
25233630-11	2014	The result of HE staining showed that FGF-21 could significantly reduce brain cell damage in the hippocampus.	Helium	14-16	fibroblast growth factor 21	Mus musculus	38-44
25233630-12	2014	The ROS and MDA levels of three different doses FGF-21 treatment group reduced significantly than that of the model group [(5.58 +/- 1.07), (7.78 +/- 1.92), (9.03 +/- 1.77) vs (12.75 +/- 2.02) pmol (DCF) x min(-1) x mg(-1), P < 0.01 or P < 0.05], [(2.92 +/- 0.71), (4.21 +/- 0.81), (4.41 +/- 0.97) vs (5.62 +/- 0.63) nmol x mg(-1) (protein), P < 0.01].	Reactive Oxygen Species	4-7	fibroblast growth factor 21	Mus musculus	48-54
25233630-12	2014	The ROS and MDA levels of three different doses FGF-21 treatment group reduced significantly than that of the model group [(5.58 +/- 1.07), (7.78 +/- 1.92), (9.03 +/- 1.77) vs (12.75 +/- 2.02) pmol (DCF) x min(-1) x mg(-1), P < 0.01 or P < 0.05], [(2.92 +/- 0.71), (4.21 +/- 0.81), (4.41 +/- 0.97) vs (5.62 +/- 0.63) nmol x mg(-1) (protein), P < 0.01].	Pentostatin	199-202	fibroblast growth factor 21	Mus musculus	48-54
25233630-14	2014	This study demonstrates that FGF-21 can ameliorate learning and memory abilities of D-galactose induced aging mice, improve the antioxidant abilities in brain tissue and delay brain aging.	Galactose	84-95	fibroblast growth factor 21	Mus musculus	29-35
24732703-6	2014	Also uncoupling induced induction and secretion of fibroblast growth factor 21 (FGF21) from SM was preserved in DTG mice.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	112-115	fibroblast growth factor 21	Mus musculus	80-85
24347058-4	2014	Targeting mitochondrial function in vitro by treating C2C12 myoblasts with the uncoupler FCCP resulted in a dose-dependent activation of ISR, which was associated with increased expression of FGF21, which was also observed by treatment with respiratory chain inhibitors antimycin A and myxothiazol.	Antimycin A	270-281	fibroblast growth factor 21	Mus musculus	192-197
24379349-1	2014	We recently reported restoration of leptin responsiveness in diet-induced obese (DIO) mice using a pharmacologically optimized, polyethylene-glycolated (PEG)-leptin analog in combination with exendin-4 or FGF21.	Polyethylene Glycols	153-156	fibroblast growth factor 21	Mus musculus	205-210
24347058-4	2014	Targeting mitochondrial function in vitro by treating C2C12 myoblasts with the uncoupler FCCP resulted in a dose-dependent activation of ISR, which was associated with increased expression of FGF21, which was also observed by treatment with respiratory chain inhibitors antimycin A and myxothiazol.	myxothiazol	286-297	fibroblast growth factor 21	Mus musculus	192-197
24184811-1	2014	BACKGROUND & AIMS: The hepatocyte-derived hormone fibroblast growth factor 21 (FGF21) is a hormone-like regulator of metabolism.	Adenosine Monophosphate	12-15	fibroblast growth factor 21	Mus musculus	54-81
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	inorganic	165-174	fibroblast growth factor 21	Mus musculus	91-96
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Phosphates	175-184	fibroblast growth factor 21	Mus musculus	91-96
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Vitamin D	194-203	fibroblast growth factor 21	Mus musculus	91-96
24688219-1	2014	Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy.	Bile Acids and Salts	205-214	fibroblast growth factor 21	Mus musculus	91-96
23839791-10	2014	The beneficial effect of HO-1 induction results from an increase in PPARalpha and FGF21 levels and a decrease in PGC1alpha, levels they were reversed by SnMP.	tin mesoporphyrin	153-157	fibroblast growth factor 21	Mus musculus	82-87
24424044-2	2014	In this study, we demonstrated that the liver-enriched transcription factor CREBH (cAMP-responsive element binding protein, hepatocyte specific) and peroxisome proliferator-activated receptor alpha (PPARalpha) function as binary transcriptional activators to regulate lipid metabolism by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis.	Cyclic AMP	83-87	fibroblast growth factor 21	Mus musculus	299-326
24424044-2	2014	In this study, we demonstrated that the liver-enriched transcription factor CREBH (cAMP-responsive element binding protein, hepatocyte specific) and peroxisome proliferator-activated receptor alpha (PPARalpha) function as binary transcriptional activators to regulate lipid metabolism by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis.	Cyclic AMP	83-87	fibroblast growth factor 21	Mus musculus	328-333
24184811-1	2014	BACKGROUND & AIMS: The hepatocyte-derived hormone fibroblast growth factor 21 (FGF21) is a hormone-like regulator of metabolism.	Adenosine Monophosphate	12-15	fibroblast growth factor 21	Mus musculus	83-88
24184811-12	2014	Decreased hepatic and circulating levels of FGF21 in fasted SIRT1 LKO mice were associated with reduced hepatic expression of genes involved in fatty acid oxidation and ketogenesis, and increased expression of genes that control lipogenesis, compared with fasted control mice.	Fatty Acids	144-154	fibroblast growth factor 21	Mus musculus	44-49
24184811-15	2014	Hepatic overexpression of FGF21 in SIRT1 LKO mice increased the expression of genes that regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased energy expenditure, and promoted browning of white adipose tissue.	Fatty Acids	98-108	fibroblast growth factor 21	Mus musculus	26-31
24401271-1	2014	The hormone FGF21 regulates carbohydrate and lipid homeostasis as well as body weight, and increasing FGF21 improves metabolic abnormalities associated with obesity and diabetes.	Carbohydrates	28-40	fibroblast growth factor 21	Mus musculus	12-17
24401271-7	2014	In contrast to its retained effects on reducing glucose levels, the effects of FGF21 on reducing circulating cholesterol and hepatic triglycerides and regulating the expression of key genes involved in cholesterol and lipid metabolism in liver were disrupted in LIRKO mice.	Cholesterol	109-120	fibroblast growth factor 21	Mus musculus	79-84
24401271-7	2014	In contrast to its retained effects on reducing glucose levels, the effects of FGF21 on reducing circulating cholesterol and hepatic triglycerides and regulating the expression of key genes involved in cholesterol and lipid metabolism in liver were disrupted in LIRKO mice.	Triglycerides	133-146	fibroblast growth factor 21	Mus musculus	79-84
24401271-7	2014	In contrast to its retained effects on reducing glucose levels, the effects of FGF21 on reducing circulating cholesterol and hepatic triglycerides and regulating the expression of key genes involved in cholesterol and lipid metabolism in liver were disrupted in LIRKO mice.	Cholesterol	202-213	fibroblast growth factor 21	Mus musculus	79-84
24900988-7	2014	Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP-/- mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme.	Thioguanine	72-74	fibroblast growth factor 21	Mus musculus	63-68
24349242-13	2013	CONCLUSION: These results suggest that FFA administration and diabetes induced renal damage, which was further enhanced in FGF21 knock-out mice.	Fatty Acids, Nonesterified	39-42	fibroblast growth factor 21	Mus musculus	123-128
24062250-12	2014	In conclusion, FGF21 acts additively with GLP-1 to prevent insulinopenic diabetes in mice lacking glucagon action.	Glucagon	98-106	fibroblast growth factor 21	Mus musculus	15-20
24349242-14	2013	Administration of FGF21 significantly prevented both FFA- and diabetes-induced renal damage partially by decreasing renal lipid accumulation and suppressing inflammation, oxidative stress, and fibrosis.	Fatty Acids, Nonesterified	53-56	fibroblast growth factor 21	Mus musculus	18-23
24279986-1	2013	BACKGROUND: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism.	Glucose	133-140	fibroblast growth factor 21	Mus musculus	22-27
24049735-5	2013	Furthermore, the transcriptional signature and cytokine secretion profile of rosiglitazone action were maintained in our FGF21KO animals.	Rosiglitazone	77-90	fibroblast growth factor 21	Mus musculus	121-126
23897951-0	2013	High glucose represses beta-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling.	Glucose	5-12	fibroblast growth factor 21	Mus musculus	58-85
23897951-4	2013	Results showed that both adult db/db mouse islets and normal islets treated with high glucose ex vivo displayed reduced beta-klotho expression, resistance to FGF21, and decreased PPARgamma expression.	Glucose	86-93	fibroblast growth factor 21	Mus musculus	158-163
24041694-7	2013	We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21.	Metformin	15-24	fibroblast growth factor 21	Mus musculus	54-59
24041694-7	2013	We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21.	Metformin	15-24	fibroblast growth factor 21	Mus musculus	133-138
23831019-0	2013	Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice.	Glucose	54-61	fibroblast growth factor 21	Mus musculus	10-15
23831019-4	2013	We therefore hypothesized that low doses of PEGylated (30K PEG on position Q108) FGF21 (PEG30-Q108) would improve insulin action, independent of any effect on food intake or body weight.	Polyox WSR-N 60	44-47	fibroblast growth factor 21	Mus musculus	81-86
23766126-1	2013	Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid metabolism and is currently being pursued as a therapeutic agent for insulin resistance and type 2 diabetes.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	0-27
23766126-1	2013	Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid metabolism and is currently being pursued as a therapeutic agent for insulin resistance and type 2 diabetes.	Glucose	61-68	fibroblast growth factor 21	Mus musculus	29-34
23766126-5	2013	This improvement in insulin responsiveness in FGF21-treated HFD-fed mice was associated with decreased hepatocellular and myocellular diacylglycerol content and reduced protein kinase Cepsilon activation in liver and protein kinase Ctheta in skeletal muscle.	Diglycerides	134-148	fibroblast growth factor 21	Mus musculus	46-51
23825123-9	2013	In cultured renal cells, FGF21 was mainly expressed in mesangial cells, and knockdown of FGF21 expression by stealth small interfering RNA further aggravated high-glucose-induced profibrotic cytokine synthesis in mesangial cells.	Glucose	163-170	fibroblast growth factor 21	Mus musculus	25-30
23825123-9	2013	In cultured renal cells, FGF21 was mainly expressed in mesangial cells, and knockdown of FGF21 expression by stealth small interfering RNA further aggravated high-glucose-induced profibrotic cytokine synthesis in mesangial cells.	Glucose	163-170	fibroblast growth factor 21	Mus musculus	89-94
23874946-0	2013	Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.	Carbohydrates	62-74	fibroblast growth factor 21	Mus musculus	0-5
23874946-13	2013	In addition, our findings indicate that Fgf21 induced to express by KD is a negative regulator of adipocyte insulin sensitivity in adaptation to a low-carbohydrate malnutritional state.	Carbohydrates	151-163	fibroblast growth factor 21	Mus musculus	40-45
23499715-3	2013	The present study examined FGF21 expression at mRNA level by real-time RT-PCR assay in the testis of fasting and non-fasting mice or mice with type 1 diabetes that was induced with streptozotocin.	Streptozocin	181-195	fibroblast growth factor 21	Mus musculus	27-32
23663741-1	2013	Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on regulating glucose and lipid homeostasis and insulin sensitivity.	Glucose	98-105	fibroblast growth factor 21	Mus musculus	0-27
23663741-1	2013	Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on regulating glucose and lipid homeostasis and insulin sensitivity.	Glucose	98-105	fibroblast growth factor 21	Mus musculus	29-34
23663742-0	2013	An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.	Ceramides	21-29	fibroblast growth factor 21	Mus musculus	3-8
23663742-5	2013	Here, we show that FGF21 rapidly and robustly stimulates adiponectin secretion in rodents while diminishing accumulation of ceramides in obese animals.	Ceramides	124-133	fibroblast growth factor 21	Mus musculus	19-24
23663742-6	2013	Importantly, adiponectin-knockout mice are refractory to changes in energy expenditure and ceramide-lowering effects evoked by FGF21 administration.	Ceramides	91-99	fibroblast growth factor 21	Mus musculus	127-132
23663742-7	2013	Moreover, FGF21 lowers blood glucose levels and enhances insulin sensitivity in diabetic Lep(ob/ob) mice and diet-induced obese (DIO) mice only when adiponectin is functionally present.	Glucose	29-36	fibroblast growth factor 21	Mus musculus	10-15
23305646-9	2013	Taken together, these data reveal for the first time that glucagon controls glucose, energy, and lipid metabolism at least in part via FGF21-dependent pathways.	Glucagon	58-66	fibroblast growth factor 21	Mus musculus	135-140
23667629-4	2013	Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body.	Glycerol	174-182	fibroblast growth factor 21	Mus musculus	27-32
23667629-4	2013	Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body.	Ketones	187-193	fibroblast growth factor 21	Mus musculus	27-32
23667629-7	2013	These results suggest that FGF21 may also be associated with exercise-induced lipolysis in addition to increased catecholamines and reduced insulin.	Catecholamines	113-127	fibroblast growth factor 21	Mus musculus	27-32
23667629-4	2013	Here, we showed that serum FGF21 level is increased in mice after a single bout of acute exercise, and that this is accompanied by increased serum levels of free fatty acid, glycerol and ketone body.	Fatty Acids, Nonesterified	157-172	fibroblast growth factor 21	Mus musculus	27-32
23305646-9	2013	Taken together, these data reveal for the first time that glucagon controls glucose, energy, and lipid metabolism at least in part via FGF21-dependent pathways.	Glucose	76-83	fibroblast growth factor 21	Mus musculus	135-140
23123503-4	2013	Moreover, intraperitoneal injection of the ER stressor tunicamycin induced hepatic Fgf21 expression in mice and resulted in marked elevation of serum FGF21 levels.	Tunicamycin	55-66	fibroblast growth factor 21	Mus musculus	83-88
23590285-9	2013	RESULTS: We found that mouse FGF21 is induced in response to chemical (DEN treatment) and genetic-induced hepatocarcinogenesis (disruptions in LKB1, p53, MST1/2, SAV1 and PTEN).	Diethylnitrosamine	71-74	fibroblast growth factor 21	Mus musculus	29-34
23430257-0	2013	Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.	Fatty Acids	99-109	fibroblast growth factor 21	Mus musculus	60-87
23430257-2	2013	The recently discovered fibroblast growth factor 21 (FGF21) is a hepatocyte-derived hormone that restores glucose and lipid homeostasis in obesity-induced diabetes.	Glucose	106-113	fibroblast growth factor 21	Mus musculus	24-51
23430257-2	2013	The recently discovered fibroblast growth factor 21 (FGF21) is a hepatocyte-derived hormone that restores glucose and lipid homeostasis in obesity-induced diabetes.	Glucose	106-113	fibroblast growth factor 21	Mus musculus	53-58
23430257-8	2013	In vivo adenoviral overexpression of RARbeta in the liver enhances production and secretion of FGF21, which in turn promotes hepatic fatty acid oxidation and ketogenesis and ultimately leads to increased energy expenditure in mice.	Fatty Acids	133-143	fibroblast growth factor 21	Mus musculus	95-100
23123503-4	2013	Moreover, intraperitoneal injection of the ER stressor tunicamycin induced hepatic Fgf21 expression in mice and resulted in marked elevation of serum FGF21 levels.	Tunicamycin	55-66	fibroblast growth factor 21	Mus musculus	150-155
23134073-3	2013	In mice, fasting leads to increased PPAR-alpha mediated expression of FGF21 in the liver where it stimulates gluconeogenesis, fatty acid oxidation, and ketogenesis, as an adaptive response to fasting and starvation.	Fatty Acids	126-136	fibroblast growth factor 21	Mus musculus	70-75
23134073-5	2013	Administration of recombinant FGF21 has been shown to confer multiple metabolic benefits on insulin sensitivity, blood glucose, lipid profile and body weight in obese mice and diabetic monkeys, without mitogenic or other side effects.	Blood Glucose	113-126	fibroblast growth factor 21	Mus musculus	30-35
23724647-2	2013	Fibroblast growth factor (FGF)-21 is a recently discovered glucose mediator and expected to be a potential anti-diabetic drug that does not rely on insulin.	Glucose	59-66	fibroblast growth factor 21	Mus musculus	0-33
23416071-2	2013	Fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism, and is an innovative candidate drug already in clinical trials for type 2 diabetes mellitus and obesity.	Glucose	63-70	fibroblast growth factor 21	Mus musculus	0-27
23416071-2	2013	Fibroblast growth factor 21 (FGF21) is a powerful modulator of glucose and lipid metabolism, and is an innovative candidate drug already in clinical trials for type 2 diabetes mellitus and obesity.	Glucose	63-70	fibroblast growth factor 21	Mus musculus	29-34
23724647-4	2013	The results showed that mFGF-21 could stably maintain the blood glucose at normal level for a long-term in a dose-dependent manner.	Glucose	64-71	fibroblast growth factor 21	Mus musculus	24-31
23724647-7	2013	Glycosylated hemoglobin level of the animals treated with mFGF-21, which represented long-term glucose status, decreased significantly compared to the control group and the insulin group.	Glucose	95-102	fibroblast growth factor 21	Mus musculus	58-65
23202295-0	2013	Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine.	mitokine	100-108	fibroblast growth factor 21	Mus musculus	89-94
23305840-9	2013	Furthermore, hepatic PKCiota/lambda phosphorylation was upregulated in FGF21-treated diabetic db/db mice.These data support the proposition that FGF21 inhibits hepatic glucose production by the PI3K-dependent activation of PKCiota/lambda.	Glucose	168-175	fibroblast growth factor 21	Mus musculus	71-76
23305840-9	2013	Furthermore, hepatic PKCiota/lambda phosphorylation was upregulated in FGF21-treated diabetic db/db mice.These data support the proposition that FGF21 inhibits hepatic glucose production by the PI3K-dependent activation of PKCiota/lambda.	Glucose	168-175	fibroblast growth factor 21	Mus musculus	145-150
23283977-2	2013	Fasting potently induces one of the key hepatic hormones, fibroblast growth factor 21 (FGF21), to promote lipolysis, fatty acid oxidation, and ketogenesis, whereas refeeding suppresses its expression.	Fatty Acids	117-127	fibroblast growth factor 21	Mus musculus	58-85
23283977-2	2013	Fasting potently induces one of the key hepatic hormones, fibroblast growth factor 21 (FGF21), to promote lipolysis, fatty acid oxidation, and ketogenesis, whereas refeeding suppresses its expression.	Fatty Acids	117-127	fibroblast growth factor 21	Mus musculus	87-92
23283977-7	2013	We demonstrate that the G9a-specific inhibitor BIX01294 abolishes suppression of the Fgf21 promoter activity by E4BP4, whereas overexpression of E4bp4 leads to increased levels of dimethylation of histone 3 lysine 9 (H3K9me2) around the Fgf21 promoter region.	BIX 01294	47-55	fibroblast growth factor 21	Mus musculus	85-90
23204296-5	2013	FGF19 and FGF21 equally improved glucose parameters; however, we observed increased serum TG and cholesterol levels after treatment with FGF19 but not with FGF21.	Glucose	33-40	fibroblast growth factor 21	Mus musculus	10-15
23771152-1	2013	Fibroblast growth factor 21 is an endocrine factor, secreted mainly by the liver, that exerts metabolic actions that favour glucose metabolism.	Glucose	124-131	fibroblast growth factor 21	Mus musculus	0-27
23771152-3	2013	Here we show that Fgf21(-/-) mice exhibit an increased relative heart weight and develop enhanced signs of dilatation and cardiac dysfunction in response to isoproterenol infusion, indicating eccentric hypertrophy development.	Isoproterenol	157-170	fibroblast growth factor 21	Mus musculus	18-23
23771152-4	2013	In addition, Fgf21(-/-) mice exhibit enhanced induction of cardiac hypertrophy markers and pro-inflammatory pathways and show greater repression of fatty acid oxidation.	Fatty Acids	148-158	fibroblast growth factor 21	Mus musculus	13-18
23202295-7	2013	These findings suggest that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone we consequently term a "mitokine", and together these processes promote protection from diet-induced obesity and insulin resistance.	mitokine	150-158	fibroblast growth factor 21	Mus musculus	98-103
23017736-7	2012	Fibroblast growth factor 21 (Fgf21) is a liver-derived anti-diabetic hormone that exerts glucose- and lipid-lowering effects.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	0-27
23301087-8	2013	In April fed-state animals, FGF21 overexpression decreased blood insulin and free fatty acid concentrations, effects similar to those seen in obese mice.	Fatty Acids, Nonesterified	77-92	fibroblast growth factor 21	Mus musculus	28-33
23017736-7	2012	Fibroblast growth factor 21 (Fgf21) is a liver-derived anti-diabetic hormone that exerts glucose- and lipid-lowering effects.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	29-34
23017736-9	2012	The inverse correlation between Nrf2 activity and hepatic expression of Fgf21 might explain the improved glucose tolerance in Nrf2-null mice.	Glucose	105-112	fibroblast growth factor 21	Mus musculus	72-77
23017736-12	2012	In conclusion, genetic alteration of Nrf2 does not prevent diet-induced obesity in mice, but deficiency of Nrf2 improves glucose homeostasis, possibly through its effects on Fgf21 and/or insulin signaling.	Glucose	121-128	fibroblast growth factor 21	Mus musculus	174-179
23066506-2	2012	Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone loss.	Fatty Acids	41-51	fibroblast growth factor 21	Mus musculus	19-24
22798348-11	2012	Body weight, glucose, insulin, cholesterol, and triglyceride levels and the GTT profile were decreased to a greater extent with Fc-FGF21(RG) than with hrFGF21.	Glucose	13-20	fibroblast growth factor 21	Mus musculus	131-136
22798348-11	2012	Body weight, glucose, insulin, cholesterol, and triglyceride levels and the GTT profile were decreased to a greater extent with Fc-FGF21(RG) than with hrFGF21.	Cholesterol	31-42	fibroblast growth factor 21	Mus musculus	131-136
22798348-11	2012	Body weight, glucose, insulin, cholesterol, and triglyceride levels and the GTT profile were decreased to a greater extent with Fc-FGF21(RG) than with hrFGF21.	Triglycerides	48-60	fibroblast growth factor 21	Mus musculus	131-136
22798348-12	2012	The PK-PD relationship of Fc-FGF21(RG) exposure and triglyceride reduction was also conducted with a maximum response model.	Triglycerides	52-64	fibroblast growth factor 21	Mus musculus	29-34
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Zymosan	14-21	fibroblast growth factor 21	Mus musculus	94-99
22696219-1	2012	Fibroblast growth factor 21 (FGF21) modulates glucose and lipid metabolism during fasting.	Glucose	46-53	fibroblast growth factor 21	Mus musculus	0-27
22696219-1	2012	Fibroblast growth factor 21 (FGF21) modulates glucose and lipid metabolism during fasting.	Glucose	46-53	fibroblast growth factor 21	Mus musculus	29-34
22661717-1	2012	Previous studies have shown that starvation or consumption of a high fat, low carbohydrate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor 21 (FGF21) gene expression in part by activating the peroxisome proliferator-activated receptor-alpha (PPARalpha).	Carbohydrates	78-90	fibroblast growth factor 21	Mus musculus	130-157
22661717-1	2012	Previous studies have shown that starvation or consumption of a high fat, low carbohydrate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor 21 (FGF21) gene expression in part by activating the peroxisome proliferator-activated receptor-alpha (PPARalpha).	Carbohydrates	78-90	fibroblast growth factor 21	Mus musculus	159-164
22661717-3	2012	In addition, we discovered that natural (i.e. bile acids) and synthetic (i.e. GW4064) activators of the farnesoid X receptor (FXR) increased FGF21 gene expression and secretion.	Bile Acids and Salts	46-56	fibroblast growth factor 21	Mus musculus	141-146
22661717-3	2012	In addition, we discovered that natural (i.e. bile acids) and synthetic (i.e. GW4064) activators of the farnesoid X receptor (FXR) increased FGF21 gene expression and secretion.	GW 4064	78-84	fibroblast growth factor 21	Mus musculus	141-146
22661717-4	2012	The effects of bile acids were additive with the effects of nonesterified unsaturated fatty acids in regulating FGF21 expression.	Bile Acids and Salts	15-25	fibroblast growth factor 21	Mus musculus	112-117
22661717-4	2012	The effects of bile acids were additive with the effects of nonesterified unsaturated fatty acids in regulating FGF21 expression.	Fatty Acids, Unsaturated	74-97	fibroblast growth factor 21	Mus musculus	112-117
22661717-6	2012	FGF19, a gut hormone whose expression and secretion is induced by intestinal bile acids, also increased hepatic FGF21 secretion.	Bile Acids and Salts	77-87	fibroblast growth factor 21	Mus musculus	112-117
22661717-9	2012	We propose that the enhanced enterohepatic flux of bile acids during HF-LC consumption leads to activation of hepatic FXR and FGF19 signaling activity and an increase in FGF21 gene expression and secretion.	Bile Acids and Salts	51-61	fibroblast growth factor 21	Mus musculus	170-175
22474187-3	2012	Here we demonstrate that lipopolysaccharide (LPS), zymosan, and turpentine, which induce the APR, increase serum FGF21 levels 2-fold.	Zymosan	51-58	fibroblast growth factor 21	Mus musculus	113-118
22474187-3	2012	Here we demonstrate that lipopolysaccharide (LPS), zymosan, and turpentine, which induce the APR, increase serum FGF21 levels 2-fold.	Turpentine	64-74	fibroblast growth factor 21	Mus musculus	113-118
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Zymosan	14-21	fibroblast growth factor 21	Mus musculus	73-78
22653558-9	2012	In addition to elevated insulin levels, prednisolone-treated mice showed a major rise in plasma leptin and fibroblast growth factor 21 levels.	Prednisolone	40-52	fibroblast growth factor 21	Mus musculus	107-134
22653558-10	2012	Our data indicate that prednisolone-induced adverse effects on glucose metabolism in high-fat diet-fed mice do not reflect impaired insulin sensitivity but may be caused by other changes in the hormonal regulatory network controlling glucose metabolism such as fibroblast growth factor 21 and leptin.	Prednisolone	23-35	fibroblast growth factor 21	Mus musculus	261-288
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Zymosan	14-21	fibroblast growth factor 21	Mus musculus	94-99
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Turpentine	27-37	fibroblast growth factor 21	Mus musculus	73-78
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Turpentine	27-37	fibroblast growth factor 21	Mus musculus	94-99
22474187-4	2012	Although LPS, zymosan, and turpentine decrease the hepatic expression of FGF21, they increase FGF21 expression in adipose tissue and muscle, suggesting that extrahepatic tissues account for the increase in serum FGF21.	Turpentine	27-37	fibroblast growth factor 21	Mus musculus	94-99
22474187-5	2012	After LPS administration, the characteristic decrease in plasma ketone levels is accentuated in FGF21-/- mice, but this is not due to differences in expression of carnitine palmitoyltransferase 1alpha or hydroxymethyglutaryl-CoA synthase 2 in liver, because LPS induces similar decreases in the expression of these genes in FGF21-/- and control mice.	Ketones	64-70	fibroblast growth factor 21	Mus musculus	96-101
22474187-6	2012	However, in FGF21-/- mice, the ability of LPS to increase plasma free fatty acid levels is blunted.	Fatty Acids, Nonesterified	65-80	fibroblast growth factor 21	Mus musculus	12-17
22067317-1	2012	Circulating levels of fibroblast growth factor 21 (FGF21), a metabolic regulator of glucose, lipid, and energy homeostasis, are elevated in obese diabetic subjects, raising questions about potential FGF21 resistance.	Glucose	84-91	fibroblast growth factor 21	Mus musculus	22-49
22338096-1	2012	Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals.	Fatty Acids	47-57	fibroblast growth factor 21	Mus musculus	29-34
22338096-1	2012	Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals.	Ketones	72-78	fibroblast growth factor 21	Mus musculus	0-27
22338096-1	2012	Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals.	Ketones	72-78	fibroblast growth factor 21	Mus musculus	29-34
22338096-2	2012	In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor.	Butyric Acid	78-93	fibroblast growth factor 21	Mus musculus	43-48
22338096-3	2012	FGF21 expression was examined in serum and liver after injection of sodium butyrate into dietary obese C57BL/6J mice.	Butyric Acid	68-83	fibroblast growth factor 21	Mus musculus	0-5
22338096-7	2012	Butyrate was compared with bezafibrate and fenofibrate in the induction of FGF21 expression.	Butyrates	0-8	fibroblast growth factor 21	Mus musculus	75-80
22338096-7	2012	Butyrate was compared with bezafibrate and fenofibrate in the induction of FGF21 expression.	Bezafibrate	27-38	fibroblast growth factor 21	Mus musculus	75-80
22338096-7	2012	Butyrate was compared with bezafibrate and fenofibrate in the induction of FGF21 expression.	Fenofibrate	43-54	fibroblast growth factor 21	Mus musculus	75-80
22338096-8	2012	Butyrate induced FGF21 in the serum, enhanced fatty acid oxidation in mice, and stimulated ketone body production in liver.	Butyrates	0-8	fibroblast growth factor 21	Mus musculus	17-22
22338096-9	2012	The butyrate activity was significantly reduced by the FGF21 antibody or gene knockout.	Butyrates	4-12	fibroblast growth factor 21	Mus musculus	55-60
22338096-10	2012	Butyrate induced FGF21 gene expression in liver and hepatocytes by inhibiting HDAC3, which suppresses peroxisome proliferator-activated receptor-alpha function.	Butyrates	0-8	fibroblast growth factor 21	Mus musculus	17-22
22338096-11	2012	Butyrate enhanced bezafibrate activity in the induction of FGF21.	Butyrates	0-8	fibroblast growth factor 21	Mus musculus	59-64
22338096-13	2012	FGF21 mediates the butyrate activity to increase fatty acid use and ketogenesis.	Butyrates	19-27	fibroblast growth factor 21	Mus musculus	0-5
22338096-13	2012	FGF21 mediates the butyrate activity to increase fatty acid use and ketogenesis.	Fatty Acids	49-59	fibroblast growth factor 21	Mus musculus	0-5
22338096-14	2012	Butyrate induces FGF21 transcription by inhibition of HDAC3.	Butyrates	0-8	fibroblast growth factor 21	Mus musculus	17-22
21767451-0	2012	Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-alpha.	Linoleic Acid	11-24	fibroblast growth factor 21	Mus musculus	55-82
21767451-5	2012	In the present study, we tested the hypothesis that FGF21 expression in the liver could be induced by t-10, c-12-CLA through PPAR-alpha.	t-10	102-106	fibroblast growth factor 21	Mus musculus	52-57
21767451-5	2012	In the present study, we tested the hypothesis that FGF21 expression in the liver could be induced by t-10, c-12-CLA through PPAR-alpha.	c-12-cla	108-116	fibroblast growth factor 21	Mus musculus	52-57
21767451-7	2012	t-10, c-12-CLA also increased serum FGF21 concentrations as measured by an ELISA.	t-10	0-4	fibroblast growth factor 21	Mus musculus	36-41
21767451-7	2012	t-10, c-12-CLA also increased serum FGF21 concentrations as measured by an ELISA.	c-12-cla	6-14	fibroblast growth factor 21	Mus musculus	36-41
21767451-8	2012	Co-transfection analysis indicated that reporter gene expression from the mouse FGF21 promoter was induced by t-10, c-12-CLA in a PPAR-alpha-dependent manner.	trans-10,cis-12-conjugated linoleic acid	110-124	fibroblast growth factor 21	Mus musculus	80-85
22370560-2	2012	FGF19 and FGF21 can regulate glucose, lipid, and energy metabolism, while FGF23 regulates phosphate homeostasis.	Glucose	29-36	fibroblast growth factor 21	Mus musculus	10-15
22338096-0	2012	Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3.	Butyric Acid	0-15	fibroblast growth factor 21	Mus musculus	41-68
22338096-1	2012	Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals.	Fatty Acids	47-57	fibroblast growth factor 21	Mus musculus	0-27
22304921-0	2012	Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones.	Thiazolidinediones	89-107	fibroblast growth factor 21	Mus musculus	0-27
22304921-1	2012	Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism.	Carbohydrates	90-102	fibroblast growth factor 21	Mus musculus	0-27
22304921-1	2012	Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism.	Carbohydrates	90-102	fibroblast growth factor 21	Mus musculus	29-34
22304921-4	2012	Moreover, FGF21-KO mice are refractory to both the beneficial insulin-sensitizing effects and the detrimental weight gain and edema side effects of the PPARgamma agonist rosiglitazone.	Rosiglitazone	170-183	fibroblast growth factor 21	Mus musculus	10-15
21767451-10	2012	This FGF21 and PPAR-alpha linkage may provide another potential explanation for the anti-obesity effect of t-10, c-12-CLA.	t-10	107-111	fibroblast growth factor 21	Mus musculus	5-10
21767451-10	2012	This FGF21 and PPAR-alpha linkage may provide another potential explanation for the anti-obesity effect of t-10, c-12-CLA.	c-12-cla	113-121	fibroblast growth factor 21	Mus musculus	5-10
22012983-10	2012	Furthermore, bezafibrate induced severe lipid oxidation effects, with hepatomegaly and loss of adipose tissue, the mechanism involving lipid mobilization by high hepatic expression of FGF21 cytokine.	Bezafibrate	13-24	fibroblast growth factor 21	Mus musculus	184-189
22067317-1	2012	Circulating levels of fibroblast growth factor 21 (FGF21), a metabolic regulator of glucose, lipid, and energy homeostasis, are elevated in obese diabetic subjects, raising questions about potential FGF21 resistance.	Glucose	84-91	fibroblast growth factor 21	Mus musculus	51-56
21696361-14	2011	FGF21 exerts pharmacological effects on glucose and lipid metabolism in hepatocytes and adipocytes.	Glucose	40-47	fibroblast growth factor 21	Mus musculus	0-5
21956711-0	2011	Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.	Exenatide	0-9	fibroblast growth factor 21	Mus musculus	28-55
23209571-12	2012	A single administration of Fc-FGF21(RG) in diabetic mice resulted in a sustained reduction in blood glucose levels and body weight gains up to 5-7 days, whereas the efficacy of FGF21 or Fc-FGF21 lasted only for 1 day.	Blood Glucose	94-107	fibroblast growth factor 21	Mus musculus	30-35
22792234-1	2012	Fibroblast growth factor 21 (FGF21) is a potent metabolic regulator, and pharmacological administration elicits glucose and lipid lowering responses in mammals.	Glucose	112-119	fibroblast growth factor 21	Mus musculus	0-27
22792234-1	2012	Fibroblast growth factor 21 (FGF21) is a potent metabolic regulator, and pharmacological administration elicits glucose and lipid lowering responses in mammals.	Glucose	112-119	fibroblast growth factor 21	Mus musculus	29-34
22174314-5	2011	In brown adipose tissues, both FGF21 and R1MAb induced phosphorylation of CREB (cyclic adenosine 5"-monophosphate response element-binding protein), and mRNA expression of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1alpha) and the downstream genes associated with oxidative metabolism.	cyclic adenosine 5"-monophosphate	80-113	fibroblast growth factor 21	Mus musculus	31-36
21846717-10	2011	In conclusion, FGF21 induces GLUT1 expression and glucose uptake through sequential activation of ERK1/2 and SRF/Elk-1, which in turn triggers the transcriptional activation of GLUT1 in adipocytes.	Glucose	50-57	fibroblast growth factor 21	Mus musculus	15-20
21846717-3	2011	Here we investigated the signaling pathways that mediate FGF21-induced GLUT1 expression and glucose uptake in vitro and in animals.	Glucose	92-99	fibroblast growth factor 21	Mus musculus	57-62
21849508-1	2011	Fibroblast growth factor (FGF) 21 and growth hormone (GH) are metabolic hormones that play important roles in regulating glucose and lipid metabolism.	Glucose	121-128	fibroblast growth factor 21	Mus musculus	0-33
21846717-5	2011	The truncation of the GLUT1 promoter from -3145 to -3105 bp, which contains two highly conserved serum response element (SRE) and E-Twenty Six (ETS) binding motif, dramatically decreased FGF21-induced promoter activity of the GLUT1 gene.	ets	144-147	fibroblast growth factor 21	Mus musculus	187-192
21846717-7	2011	The siRNA-mediated knockdown of either SRF or Elk-1 resulted in a marked attenuation in FGF21-induced GLUT1 expression and glucose uptake in adipocytes.	Glucose	123-130	fibroblast growth factor 21	Mus musculus	88-93
21846717-8	2011	In C57 lean mice, a single intravenous injection of FGF21 induced phosphorylation of Elk-1 at Ser(383) and SRF at Ser(103) and also led to the recruitment of Elk-1 and SRF to the GLUT1 promoter in epididymal fats.	Serine	94-97	fibroblast growth factor 21	Mus musculus	52-57
21846717-8	2011	In C57 lean mice, a single intravenous injection of FGF21 induced phosphorylation of Elk-1 at Ser(383) and SRF at Ser(103) and also led to the recruitment of Elk-1 and SRF to the GLUT1 promoter in epididymal fats.	Serine	114-117	fibroblast growth factor 21	Mus musculus	52-57
21849508-6	2011	Such a stimulatory effect of GH on hepatic FGF21 production is abrogated by pretreatment of mice with the lipolysis inhibitor niacin.	Niacin	126-132	fibroblast growth factor 21	Mus musculus	43-48
21712364-1	2011	Fibroblast growth factor (FGF21) plays an important role in regulating hepatic oxidation of fatty acids and gluconeogenesis in response to fasting and during consumption of a ketogenic diet.	Fatty Acids	92-103	fibroblast growth factor 21	Mus musculus	26-31
21712364-6	2011	In addition, injection of FGF21 was associated with decreased circulating insulin and free fatty acid levels.	Fatty Acids, Nonesterified	86-101	fibroblast growth factor 21	Mus musculus	26-31
22007513-5	2011	Administration of FGF-21 increased the expression of GLUT1 and stimulated GLUT1-mediated glucose uptake.	Glucose	89-96	fibroblast growth factor 21	Mus musculus	18-24
21720023-4	2011	Intraperitoneal injection of both bezafibrate and pioglitazone induced FGF21 mRNA expression in the mouse liver.	Bezafibrate	34-45	fibroblast growth factor 21	Mus musculus	71-76
21293445-0	2011	Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.	Hydrogen	10-18	fibroblast growth factor 21	Mus musculus	69-74
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	h(2)-water	24-34	fibroblast growth factor 21	Mus musculus	191-218
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	h(2)-water	24-34	fibroblast growth factor 21	Mus musculus	220-225
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	Fatty Acids	255-265	fibroblast growth factor 21	Mus musculus	191-218
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	Fatty Acids	255-265	fibroblast growth factor 21	Mus musculus	220-225
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	Glucose	270-277	fibroblast growth factor 21	Mus musculus	191-218
21293445-8	2011	To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure.	Glucose	270-277	fibroblast growth factor 21	Mus musculus	220-225
21346090-1	2011	Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family in homology studies and is a member of the endocrine FGF subfamily that lacks heparin binding domains and is released into the circulation.	Heparin	170-177	fibroblast growth factor 21	Mus musculus	0-27
21346090-1	2011	Fibroblast growth factor 21 (FGF21) was originally identified as a member of the FGF family in homology studies and is a member of the endocrine FGF subfamily that lacks heparin binding domains and is released into the circulation.	Heparin	170-177	fibroblast growth factor 21	Mus musculus	29-34
21346090-2	2011	A potential role as a metabolic regulator emerged when FGF21 was shown to increase glucose uptake in adipocytes.	Glucose	83-90	fibroblast growth factor 21	Mus musculus	55-60
21346090-3	2011	Subsequently, marked elevations in FGF21 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF21 expression plays a role in the adaptation to metabolic states that require increased fatty acid oxidation.	Fatty Acids	229-239	fibroblast growth factor 21	Mus musculus	35-40
21346090-3	2011	Subsequently, marked elevations in FGF21 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF21 expression plays a role in the adaptation to metabolic states that require increased fatty acid oxidation.	Fatty Acids	229-239	fibroblast growth factor 21	Mus musculus	138-143
21720023-4	2011	Intraperitoneal injection of both bezafibrate and pioglitazone induced FGF21 mRNA expression in the mouse liver.	Pioglitazone	50-62	fibroblast growth factor 21	Mus musculus	71-76
21720023-5	2011	Rosiglitazone and pioglitazone as well as bezafibrate significantly induced FGF21 mRNA expression in cultured mouse hepatocytes.	Rosiglitazone	0-13	fibroblast growth factor 21	Mus musculus	76-81
21720023-5	2011	Rosiglitazone and pioglitazone as well as bezafibrate significantly induced FGF21 mRNA expression in cultured mouse hepatocytes.	Pioglitazone	18-30	fibroblast growth factor 21	Mus musculus	76-81
21720023-8	2011	Our findings suggest that PPARgamma-activating antidiabetic drugs such as rosiglitazone and pioglitazone induce FGF21 expression in mouse and human hepatocytes, and that PPARgamma rather than PPARalpha might play an important role in human FGF21 production.	Rosiglitazone	74-87	fibroblast growth factor 21	Mus musculus	112-117
21720023-8	2011	Our findings suggest that PPARgamma-activating antidiabetic drugs such as rosiglitazone and pioglitazone induce FGF21 expression in mouse and human hepatocytes, and that PPARgamma rather than PPARalpha might play an important role in human FGF21 production.	Pioglitazone	92-104	fibroblast growth factor 21	Mus musculus	112-117
20735016-6	2010	Pharmacokinetic studies indicate that SR1078 displays reasonable exposure following injection into mice, and consistent with SR1078 functioning as a RORalpha/RORgamma agonist, expression of two ROR target genes, glucose-6-phosphatase and fibroblast growth factor 21, were stimulated in the liver.	SR 1078	38-44	fibroblast growth factor 21	Mus musculus	238-265
21829679-1	2011	Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and actions of FGF21 in humans remain unclear.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	0-27
21829679-1	2011	Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism in mouse, but the regulatory mechanisms and actions of FGF21 in humans remain unclear.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	29-34
21331285-5	2011	Experiments with Fgf21 transgenic mice and cultured cells indicate that FGF21 exerts pharmacological effects on glucose and lipid metabolism in hepatocytes and adipocytes via cell surface FGF receptors.	Glucose	112-119	fibroblast growth factor 21	Mus musculus	72-77
21373720-1	2011	Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue.	Glucose	73-80	fibroblast growth factor 21	Mus musculus	0-27
21373720-1	2011	Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue.	Glucose	73-80	fibroblast growth factor 21	Mus musculus	29-34
20424589-2	2010	We recently reported that bezafibrate, a pan-agonist of PPARs, decreases body temperature late at night through hypothalamic neuropeptide Y (NPY) activation and others have shown that mice overexpressing FGF21 are prone to torpor.	Bezafibrate	26-37	fibroblast growth factor 21	Mus musculus	204-209
20851878-1	2010	Fibroblast growth factor 21 (FGF21) is a potent antidiabetic and triglyceride-lowering hormone whose hepatic expression is highly responsive to food intake.	Triglycerides	65-77	fibroblast growth factor 21	Mus musculus	0-27
20851878-1	2010	Fibroblast growth factor 21 (FGF21) is a potent antidiabetic and triglyceride-lowering hormone whose hepatic expression is highly responsive to food intake.	Triglycerides	65-77	fibroblast growth factor 21	Mus musculus	29-34
20616029-6	2010	FGF21 treatment increased cellular NAD(+) levels, leading to activation of SIRT1 and deacetylation of its downstream targets, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and histone 3.	NAD	35-41	fibroblast growth factor 21	Mus musculus	0-5
20616029-7	2010	Activation of AMPK and SIRT1 by FGF21 in adipocytes enhanced mitochondrial oxidative capacity as demonstrated by increases in oxygen consumption, citrate synthase activity, and induction of key metabolic genes.	Oxygen	126-132	fibroblast growth factor 21	Mus musculus	32-37
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	fibroblast growth factor 21	Mus musculus	79-84
20616029-9	2010	Inhibition of AMPK, SIRT1, and PGC-1alpha activities attenuated the effects of FGF21 on oxygen consumption and gene expression, indicating that FGF21 regulates mitochondrial activity and enhances oxidative capacity through an AMPK-SIRT1-PGC1alpha-dependent mechanism in adipocytes.	Oxygen	88-94	fibroblast growth factor 21	Mus musculus	144-149
19906798-2	2010	Pharmacologic studies show that FGF21 has broad metabolic actions in obese rodents and primates that include enhancing insulin sensitivity, decreasing triglyceride concentrations, and causing weight loss.	Triglycerides	151-163	fibroblast growth factor 21	Mus musculus	32-37
19906798-4	2010	FGF21, in turn, induces the transcriptional coactivator protein peroxisome proliferator-activated receptor gamma coactivator protein 1alpha and stimulates hepatic gluconeogenesis, fatty acid oxidation, and ketogenesis.	Fatty Acids	180-190	fibroblast growth factor 21	Mus musculus	0-5
20682689-1	2010	OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism.	Fatty Acids	68-78	fibroblast growth factor 21	Mus musculus	11-38
20682689-1	2010	OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism.	Fatty Acids	68-78	fibroblast growth factor 21	Mus musculus	40-45
20682689-2	2010	Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight loss in obese mice.	Fatty Acids, Nonesterified	70-86	fibroblast growth factor 21	Mus musculus	25-30
20682689-4	2010	However, the expected beneficial effects of endogenous FGF21 to increase glucose tolerance and reduce circulating triglycerides are absent in obesity.	Triglycerides	114-127	fibroblast growth factor 21	Mus musculus	55-60
20682689-10	2010	Similarly, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGF21-treated DIO mice.	Glucose	62-69	fibroblast growth factor 21	Mus musculus	109-114
20682689-10	2010	Similarly, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGF21-treated DIO mice.	Fatty Acids, Nonesterified	74-90	fibroblast growth factor 21	Mus musculus	109-114
20663988-0	2010	Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo.	Glucagon	0-8	fibroblast growth factor 21	Mus musculus	108-113
20663988-2	2010	The hypothesis that increases in hepatic glucagon action stimulate AMP-activated protein kinase (AMPK) signaling and peroxisome proliferator-activated receptor-alpha (PPARalpha) and fibroblast growth factor 21 (FGF21) expression in a manner modulated by fatty acids was tested in vivo.	Fatty Acids	254-265	fibroblast growth factor 21	Mus musculus	211-216
20663988-6	2010	It blunted glucagon-stimulated acetyl-CoA carboxylase phosphorylation, a downstream target of AMPK, and accentuated PPARalpha and FGF21 expression.	Glucagon	11-19	fibroblast growth factor 21	Mus musculus	130-135
20663988-8	2010	These findings demonstrate that glucagon exerts a critical regulatory role in liver to stimulate pathways linked to lipid metabolism in vivo and shows for the first time that effects of glucagon on PPARalpha and FGF21 expression are amplified by a physiological increase in circulating lipids.	Glucagon	32-40	fibroblast growth factor 21	Mus musculus	212-217
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	18-35	fibroblast growth factor 21	Mus musculus	138-165
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	18-35	fibroblast growth factor 21	Mus musculus	167-172
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	37-39	fibroblast growth factor 21	Mus musculus	138-165
20236931-2	2010	Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21).	Triiodothyronine	37-39	fibroblast growth factor 21	Mus musculus	167-172
20197053-4	2010	Changes in FGF21 expression due to suckling or nutritional manipulations were associated with circulating free fatty acid and ketone body levels.	Fatty Acids, Nonesterified	106-121	fibroblast growth factor 21	Mus musculus	11-16
20197053-4	2010	Changes in FGF21 expression due to suckling or nutritional manipulations were associated with circulating free fatty acid and ketone body levels.	Ketones	126-132	fibroblast growth factor 21	Mus musculus	11-16
20018895-1	2010	FGF19 and FGF21, unique members of the fibroblast growth factor (FGF) family, are hormones that regulate glucose, lipid, and energy homeostasis.	Glucose	105-112	fibroblast growth factor 21	Mus musculus	10-15
20018698-6	2009	Modulation of intracellular heme levels mimics the effect of PGC-1alpha on FGF21 expression, and inhibition of heme biosynthesis completely abrogates the down-regulation of FGF21 in response to PGC-1alpha.	Heme	28-32	fibroblast growth factor 21	Mus musculus	75-80
20018698-6	2009	Modulation of intracellular heme levels mimics the effect of PGC-1alpha on FGF21 expression, and inhibition of heme biosynthesis completely abrogates the down-regulation of FGF21 in response to PGC-1alpha.	Heme	28-32	fibroblast growth factor 21	Mus musculus	173-178
20018698-6	2009	Modulation of intracellular heme levels mimics the effect of PGC-1alpha on FGF21 expression, and inhibition of heme biosynthesis completely abrogates the down-regulation of FGF21 in response to PGC-1alpha.	Heme	111-115	fibroblast growth factor 21	Mus musculus	173-178
19706786-0	2009	Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.	Glucose	6-13	fibroblast growth factor 21	Mus musculus	57-62
19706786-11	2009	We conclude that the acute glucose-lowering and insulin-sensitizing effects of FGF21 are potentially associated with its metabolic actions in liver and adipose tissues.	Glucose	27-34	fibroblast growth factor 21	Mus musculus	79-84
19706786-4	2009	We show that FGF21 resulted in rapid decline of blood glucose levels and immediate improvement of glucose tolerance and insulin sensitivity in two animal models of insulin resistance (ob/ob and DIO mice).	Glucose	54-61	fibroblast growth factor 21	Mus musculus	13-18
19706786-6	2009	In DIO mice, FGF21 reduced fasting blood glucose and insulin levels and improved glucose tolerance and insulin sensitivity within 3 h of treatment.	Glucose	41-48	fibroblast growth factor 21	Mus musculus	13-18
19664632-1	2009	BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) acts as a hormonal regulator during fasting and is involved in lipid metabolism.	Adenosine Monophosphate	12-15	fibroblast growth factor 21	Mus musculus	23-50
19819944-6	2009	In contrast to wild-type animals in which feeding KD leads to dramatic weight loss, FGF21KO mice fed KD gained weight, developed hepatosteatosis, and showed marked impairments in ketogenesis and glucose control.	Glucose	195-202	fibroblast growth factor 21	Mus musculus	84-89
19531026-1	2009	FGF21 is a novel member of the FGFs family, is mainly expressed in liver and it functions as a potent activator of glucose uptake on adipocytes.	Glucose	115-122	fibroblast growth factor 21	Mus musculus	0-5
19819944-2	2009	Expressed primarily in liver and adipose tissue, FGF21 is induced via peroxisome proliferator-activated receptor (PPAR) pathways during states requiring increased fatty acid oxidation including fasting and consumption of a ketogenic diet.	Fatty Acids	163-173	fibroblast growth factor 21	Mus musculus	49-54
19664632-1	2009	BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) acts as a hormonal regulator during fasting and is involved in lipid metabolism.	Adenosine Monophosphate	12-15	fibroblast growth factor 21	Mus musculus	52-57
19664632-4	2009	METHODS: Fgf21 expression was quantified during cerulein-induced pancreatitis (CIP) or following mechanical or thapsigargin-induced stress through Northern blot analysis, in situ hybridization, and quantitative reverse transcription polymerase chain reaction.	Thapsigargin	111-123	fibroblast growth factor 21	Mus musculus	9-14
19751733-4	2009	Here we report that a single injection of FGF21 acutely reduced plasma free fatty acid levels similar to its acute effects on plasma glucose in ob/ob mice.	Glucose	133-140	fibroblast growth factor 21	Mus musculus	42-47
19751733-0	2009	Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice.	Glucose	81-88	fibroblast growth factor 21	Mus musculus	92-97
19470704-4	2009	Results show that chronic FGF21 ameliorated fasting hyperglycemia in ob/ob mice via increased glucose disposal and improved hepatic insulin sensitivity.	Glucose	94-101	fibroblast growth factor 21	Mus musculus	26-31
19751733-1	2009	FGF21 is a unique member of the fibroblast growth factors (FGFs) and a novel hormone that regulates glucose, lipid, and energy homeostasis.	Glucose	100-107	fibroblast growth factor 21	Mus musculus	0-5
19751733-4	2009	Here we report that a single injection of FGF21 acutely reduced plasma free fatty acid levels similar to its acute effects on plasma glucose in ob/ob mice.	Fatty Acids, Nonesterified	71-86	fibroblast growth factor 21	Mus musculus	42-47
19589869-4	2009	The phenotypes of hepatic Fgf21 transgenic or knockdown mice and high-fat, low-carbohydrate ketogenic diet-fed mice suggests that Fgf21 stimulates lipolysis in the white adipose tissue during normal feeding and is required for ketogenesis and triglyceride clearance in the liver during fasting.	Carbohydrates	79-91	fibroblast growth factor 21	Mus musculus	130-135
19589869-4	2009	The phenotypes of hepatic Fgf21 transgenic or knockdown mice and high-fat, low-carbohydrate ketogenic diet-fed mice suggests that Fgf21 stimulates lipolysis in the white adipose tissue during normal feeding and is required for ketogenesis and triglyceride clearance in the liver during fasting.	Triglycerides	243-255	fibroblast growth factor 21	Mus musculus	130-135
19589869-9	2009	However, hypertrophy of adipocytes, decreased lipolysis in adipocytes, and decreased blood nonesterified fatty acid levels were observed when Fgf21 KO mice were fed normally.	Fatty Acids, Nonesterified	91-115	fibroblast growth factor 21	Mus musculus	142-147
19589869-10	2009	In contrast, increased lipolysis in adipocytes and increased blood nonesterified fatty acid levels were observed in Fgf21 KO mice by fasting for 24 h, indicating that Fgf21 stimulates lipolysis in the white adipose tissue during feeding but inhibits it during fasting.	Fatty Acids, Nonesterified	67-91	fibroblast growth factor 21	Mus musculus	116-121
19589869-10	2009	In contrast, increased lipolysis in adipocytes and increased blood nonesterified fatty acid levels were observed in Fgf21 KO mice by fasting for 24 h, indicating that Fgf21 stimulates lipolysis in the white adipose tissue during feeding but inhibits it during fasting.	Fatty Acids, Nonesterified	67-91	fibroblast growth factor 21	Mus musculus	167-172
19660458-5	2009	Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp.	Glucose	88-95	fibroblast growth factor 21	Mus musculus	39-44
19470704-5	2009	Acute FGF21 suppressed hepatic glucose production, increased liver glycogen, lowered glucagon, and improved glucose clearance in ob/+ mice.	Glucose	31-38	fibroblast growth factor 21	Mus musculus	6-11
19470704-5	2009	Acute FGF21 suppressed hepatic glucose production, increased liver glycogen, lowered glucagon, and improved glucose clearance in ob/+ mice.	Glycogen	67-75	fibroblast growth factor 21	Mus musculus	6-11
19470704-5	2009	Acute FGF21 suppressed hepatic glucose production, increased liver glycogen, lowered glucagon, and improved glucose clearance in ob/+ mice.	Glucagon	85-93	fibroblast growth factor 21	Mus musculus	6-11
19470704-5	2009	Acute FGF21 suppressed hepatic glucose production, increased liver glycogen, lowered glucagon, and improved glucose clearance in ob/+ mice.	Glucose	108-115	fibroblast growth factor 21	Mus musculus	6-11
18187602-1	2008	Fibroblast growth factor (FGF) 21, a structural relative of FGF23 that regulates phosphate homeostasis, is a regulator of insulin-independent glucose transport in adipocytes and plays a role in the regulation of body weight.	Phosphates	81-90	fibroblast growth factor 21	Mus musculus	0-33
19541642-0	2009	FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.	Carbohydrates	39-51	fibroblast growth factor 21	Mus musculus	0-5
19541642-0	2009	FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.	Fatty Acids	56-66	fibroblast growth factor 21	Mus musculus	0-5
19541642-4	2009	Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha), a key transcriptional regulator of energy homeostasis, and causes corresponding increases in fatty acid oxidation, tricarboxylic acid cycle flux, and gluconeogenesis without increasing glycogenolysis.	Fatty Acids	316-326	fibroblast growth factor 21	Mus musculus	19-46
19541642-4	2009	Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha), a key transcriptional regulator of energy homeostasis, and causes corresponding increases in fatty acid oxidation, tricarboxylic acid cycle flux, and gluconeogenesis without increasing glycogenolysis.	Fatty Acids	316-326	fibroblast growth factor 21	Mus musculus	48-53
19541642-4	2009	Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha), a key transcriptional regulator of energy homeostasis, and causes corresponding increases in fatty acid oxidation, tricarboxylic acid cycle flux, and gluconeogenesis without increasing glycogenolysis.	Tricarboxylic Acids	338-356	fibroblast growth factor 21	Mus musculus	19-46
19541642-4	2009	Here, we show that fibroblast growth factor 21 (FGF21), a hormone that is induced in liver by fasting, induces hepatic expression of peroxisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha), a key transcriptional regulator of energy homeostasis, and causes corresponding increases in fatty acid oxidation, tricarboxylic acid cycle flux, and gluconeogenesis without increasing glycogenolysis.	Tricarboxylic Acids	338-356	fibroblast growth factor 21	Mus musculus	48-53
19541642-6	2009	These results reveal an unexpected relationship between FGF21 and PGC-1alpha and demonstrate an important role for FGF21 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fasting to starvation.	Carbohydrates	148-160	fibroblast growth factor 21	Mus musculus	115-120
19541642-6	2009	These results reveal an unexpected relationship between FGF21 and PGC-1alpha and demonstrate an important role for FGF21 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fasting to starvation.	Fatty Acids	165-175	fibroblast growth factor 21	Mus musculus	115-120
18840786-1	2009	OBJECTIVE: Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism.	Glucose	98-105	fibroblast growth factor 21	Mus musculus	11-38
18840786-1	2009	OBJECTIVE: Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism.	Glucose	98-105	fibroblast growth factor 21	Mus musculus	40-45
18840786-8	2009	The profound reduction of hepatic triglyceride levels was associated with FGF21 inhibition of nuclear sterol regulatory element binding protein-1 and the expression of a wide array of genes involved in fatty acid and triglyceride synthesis.	Triglycerides	34-46	fibroblast growth factor 21	Mus musculus	74-79
18840432-3	2008	We found that a nighttime injection of bezafibrate, a ligand of PPARalpha, effectively induced FGF21 expression, whereas a daytime injection did not affect it.	Bezafibrate	39-50	fibroblast growth factor 21	Mus musculus	95-100
18840432-4	2008	Furthermore, bezafibrate-induced circadian FGF21 expression was abolished in PPARalpha-deficient mice.	Bezafibrate	13-24	fibroblast growth factor 21	Mus musculus	43-48
18840432-5	2008	These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARalpha system in the liver.	Bezafibrate	32-43	fibroblast growth factor 21	Mus musculus	62-67
18948104-6	2008	In cultured skeletal muscle cells, FGF21 expression and secretion was regulated by insulin, Akt transduction and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	fibroblast growth factor 21	Mus musculus	35-40
18187602-1	2008	Fibroblast growth factor (FGF) 21, a structural relative of FGF23 that regulates phosphate homeostasis, is a regulator of insulin-independent glucose transport in adipocytes and plays a role in the regulation of body weight.	Glucose	142-149	fibroblast growth factor 21	Mus musculus	0-33
17452648-1	2007	Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes.	Glucose	88-95	fibroblast growth factor 21	Mus musculus	0-27
17550778-4	2007	Importantly, adenoviral knockdown of hepatic FGF21 in KD-fed mice causes fatty liver, lipemia, and reduced serum ketones, due at least in part to altered expression of key genes governing lipid and ketone metabolism.	Ketones	113-120	fibroblast growth factor 21	Mus musculus	45-50
17550778-4	2007	Importantly, adenoviral knockdown of hepatic FGF21 in KD-fed mice causes fatty liver, lipemia, and reduced serum ketones, due at least in part to altered expression of key genes governing lipid and ketone metabolism.	Ketones	113-119	fibroblast growth factor 21	Mus musculus	45-50
17550778-5	2007	Hence, induction of FGF21 in liver is required for the normal activation of hepatic lipid oxidation, triglyceride clearance, and ketogenesis induced by KD.	Triglycerides	101-113	fibroblast growth factor 21	Mus musculus	20-25
17452648-1	2007	Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes.	Glucose	88-95	fibroblast growth factor 21	Mus musculus	29-34
17452648-4	2007	Knockdown of betaKlotho expression by siRNA in adipocytes diminishes glucose uptake induced by FGF21.	Glucose	69-76	fibroblast growth factor 21	Mus musculus	95-100
16936195-7	2006	Short-term treatment of normal or db/db mice with FGF-21 lowered plasma levels of insulin and improved glucose clearance compared with vehicle after oral glucose tolerance testing.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	50-56
16929488-6	2006	We showed that similar to FGF1 and FGF2, FGF21 mRNA was upregulated in neoplastic and regenerating liver after partial hepatectomy (PH) and CCl4 administration.	Carbon Tetrachloride	140-144	fibroblast growth factor 21	Mus musculus	41-46
16929488-9	2006	Surprisingly, overexpression of FGF21 delayed the appearance of DEN-induced liver tumors.	Diethylnitrosamine	64-67	fibroblast growth factor 21	Mus musculus	32-37
16936195-7	2006	Short-term treatment of normal or db/db mice with FGF-21 lowered plasma levels of insulin and improved glucose clearance compared with vehicle after oral glucose tolerance testing.	Glucose	154-161	fibroblast growth factor 21	Mus musculus	50-56
16936195-8	2006	Constant infusion of FGF-21 for 8 weeks in db/db mice nearly normalized fed blood glucose levels and increased plasma insulin levels.	Glucose	82-89	fibroblast growth factor 21	Mus musculus	21-27
24935677-8	2014	Mice restricted of methionine exhibited increased circulating and hepatic gene expression levels of FGF21, phosphorylation of eIF2a, and expression of ATF4, with a concomitant decrease in IRE1alpha phosphorylation.	Methionine	19-29	fibroblast growth factor 21	Mus musculus	100-105
15902306-2	2005	Here we describe a potential novel therapeutic agent for this disease, FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes.	Glucose	128-135	fibroblast growth factor 21	Mus musculus	71-77
15902306-4	2005	Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice.	Glucose	52-59	fibroblast growth factor 21	Mus musculus	30-36
15902306-4	2005	Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice.	Triglycerides	64-77	fibroblast growth factor 21	Mus musculus	30-36
33761350-0	2021	FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.	Glucose	78-85	fibroblast growth factor 21	Mus musculus	17-22
33761350-4	2021	Knockout of hepatic Foxo1 in LDKO mice or direct restoration of Fgf21 by adenoviral infection restored glucose utilization by BAT (brown adipose tissue) and skeletal muscle, normalized thermogenic gene expression in LDKO BAT, and corrected acute cold intolerance of LDKO mice.	Glucose	103-110	fibroblast growth factor 21	Mus musculus	64-69
33799938-11	2021	We found that fenofibrate boosted liver function, increased serum levels of fibroblast growth factor 21 (FGF21), one of the neuroprotective molecules in the central nervous system, and protected against UCCAO-induced retinal dysfunction.	Fenofibrate	14-25	fibroblast growth factor 21	Mus musculus	76-103
33799938-11	2021	We found that fenofibrate boosted liver function, increased serum levels of fibroblast growth factor 21 (FGF21), one of the neuroprotective molecules in the central nervous system, and protected against UCCAO-induced retinal dysfunction.	Fenofibrate	14-25	fibroblast growth factor 21	Mus musculus	105-110
33588950-0	2021	Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice.	Glucose	99-106	fibroblast growth factor 21	Mus musculus	35-40
33588950-8	2021	In the T2DM mouse model, the transplantation of MSC-FGF21+GLP1 cells ameliorated the changes in blood glucose and weight, promoted the secretion of insulin, enhanced the recovery of liver structures, and improved the profiles of lipids.	Glucose	102-109	fibroblast growth factor 21	Mus musculus	52-57
33588950-9	2021	Moreover, FGF21 and GLP1 exerted synergistic effects in the regulation of glucolipid metabolism by controlling the expression of insulin, srebp1, and srebp2.	glucolipid	74-84	fibroblast growth factor 21	Mus musculus	10-15
33822771-9	2021	These findings demonstrate that amlexanox improved metabolic health via FGF21 action in adipocytes to increase energy expenditure via WAT beiging, and an endocrine role of adipocyte-derived IL-6 to decrease gluconeogenesis via hepatic STAT3 activation, thereby producing a coordinated improvement in metabolic parameters.	amlexanox	32-41	fibroblast growth factor 21	Mus musculus	72-77
33765615-0	2021	Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21.	Methionine	0-10	fibroblast growth factor 21	Mus musculus	71-98
34634192-7	2022	Nimesulide treatment improved insulin sensitivity and glycemic control, increased GLP-1, decreased liver lipids, and improved FGF-21 in serum.	nimesulide	0-10	fibroblast growth factor 21	Mus musculus	126-132
34624498-11	2022	Overall, at 3mCvs FGF21 was involved in maintaining mitochondrial activity, attenuating de novo lipogenesis, increased fatty acid uptake and histone acetyltransferase activity.	Fatty Acids	119-129	fibroblast growth factor 21	Mus musculus	18-23
34801693-8	2022	Neither weight loss induced by VSG nor improved glucose tolerance by metformin treatment could revert hepatic Fgf21 DNA methylation or expression.	Metformin	69-78	fibroblast growth factor 21	Mus musculus	110-115
34826932-1	2022	Perfluorooctanoic acid (PFOA), a hazardous environmental pollutant, has been found to enhance hepatic synthesis of fibroblast growth factor 21 (FGF21).	perfluorooctanoic acid	0-22	fibroblast growth factor 21	Mus musculus	115-142
34826932-1	2022	Perfluorooctanoic acid (PFOA), a hazardous environmental pollutant, has been found to enhance hepatic synthesis of fibroblast growth factor 21 (FGF21).	perfluorooctanoic acid	0-22	fibroblast growth factor 21	Mus musculus	144-149
34826932-1	2022	Perfluorooctanoic acid (PFOA), a hazardous environmental pollutant, has been found to enhance hepatic synthesis of fibroblast growth factor 21 (FGF21).	perfluorooctanoic acid	24-28	fibroblast growth factor 21	Mus musculus	115-142
34826932-4	2022	Exposure of mice to PFOA (1 mg kg-1 bw) for 10 consecutive days (PFOA-mice) caused anxiety-like behaviors and a peroxisome proliferator-activated receptor alpha (PPARalpha)-dependent increase in hepatic FGF21 synthesis.	perfluorooctanoic acid	20-24	fibroblast growth factor 21	Mus musculus	203-208
34826932-1	2022	Perfluorooctanoic acid (PFOA), a hazardous environmental pollutant, has been found to enhance hepatic synthesis of fibroblast growth factor 21 (FGF21).	perfluorooctanoic acid	24-28	fibroblast growth factor 21	Mus musculus	144-149
34826932-4	2022	Exposure of mice to PFOA (1 mg kg-1 bw) for 10 consecutive days (PFOA-mice) caused anxiety-like behaviors and a peroxisome proliferator-activated receptor alpha (PPARalpha)-dependent increase in hepatic FGF21 synthesis.	perfluorooctanoic acid	65-69	fibroblast growth factor 21	Mus musculus	203-208
34715121-4	2022	FGF21-Tg mice displayed reduced preference for morphine in the conditioned place preference assay compared to WT littermates.	Morphine	47-55	fibroblast growth factor 21	Mus musculus	0-5
34826932-9	2022	Thus, the results indicate that the exposure of male mice to PFOA (1 mg kg-1 bw) enhances CRF expression in BLA neurons by increasing hepatic FGF21 synthesis, which then enhances CRF-R1-mediated presynaptic glutamate release to facilitate NMDAR-dependent BLA-LTP induction, leading to the production of anxiety-like behaviors.	perfluorooctanoic acid	61-65	fibroblast growth factor 21	Mus musculus	142-147
34715121-5	2022	Similarly, FGF21-Tg mice had an attenuation of the magnitude and rate of acute morphine antinociceptive tolerance development, and acute and chronic morphine physical dependence, but exhibited no change in chronic morphine antinociceptive tolerance.	Morphine	79-87	fibroblast growth factor 21	Mus musculus	11-16
34715121-0	2022	Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence.	Morphine	63-71	fibroblast growth factor 21	Mus musculus	15-20
34715121-5	2022	Similarly, FGF21-Tg mice had an attenuation of the magnitude and rate of acute morphine antinociceptive tolerance development, and acute and chronic morphine physical dependence, but exhibited no change in chronic morphine antinociceptive tolerance.	Morphine	149-157	fibroblast growth factor 21	Mus musculus	11-16
34715121-2	2022	Previous studies showed that fibroblast growth factor 21 (FGF21) decreased alcohol and sweet preference in mice.	Alcohols	75-82	fibroblast growth factor 21	Mus musculus	29-56
34715121-2	2022	Previous studies showed that fibroblast growth factor 21 (FGF21) decreased alcohol and sweet preference in mice.	Alcohols	75-82	fibroblast growth factor 21	Mus musculus	58-63
34715121-8	2022	Overall, FGF21-Tg mice had a decrease in the development of acute analgesic tolerance, and the development of physical dependence, and morphine preference.	Morphine	135-143	fibroblast growth factor 21	Mus musculus	9-14
34774619-0	2021	Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARdelta-mediated suppression of inflammation.	dimethyl itaconate	0-18	fibroblast growth factor 21	Mus musculus	109-114
34774619-8	2021	AMPK phosphorylation, as well as PPARdelta and myokine FGF21 expression, were enhanced in C2C12 myocytes by DITA treatment.	dimethyl itaconate	108-112	fibroblast growth factor 21	Mus musculus	55-60
34774619-9	2021	siRNA-mediated suppression of AMPK or FGF21 expression abolished the effects of DITA on insulin resistance and inflammation in palmitate-treated C2C12 myocytes.	dimethyl itaconate	80-84	fibroblast growth factor 21	Mus musculus	38-43
34774619-10	2021	SIGNIFICANCE: In sum, DITA suppresses inflammation through the AMPK/FGF21/PPARdelta signaling, thereby alleviating insulin resistance in palmitate-treated C2C12 myocytes.	dimethyl itaconate	22-26	fibroblast growth factor 21	Mus musculus	68-73
34830222-6	2021	In contrast, knockout of Fgf21 weakened the cardioprotective effects of AET after MI.	2-(2-Aminoethyl)isothiourea dihydrobromide	72-75	fibroblast growth factor 21	Mus musculus	25-30
34695409-2	2021	Studies demonstrate that FGF21 combined with Insulin exhibits reciprocal sensitization on glucose and lipid metabolism in mice with type 2 diabetes.	Glucose	90-97	fibroblast growth factor 21	Mus musculus	25-30
34917917-6	2021	This study has shown that mechanistically, via the elevation of hepatic FGF21, p38alpha activation increases the influx of fatty acids from the adipose tissue to liver, resulting in hepatic ectopic lipid accumulation and insulin resistance.	Fatty Acids	123-134	fibroblast growth factor 21	Mus musculus	72-77
34773993-0	2021	Fibroblast growth factor 21 attenuates salt-sensitive hypertension-induced nephropathy through anti-inflammation and anti-oxidation mechanism.	Salts	39-43	fibroblast growth factor 21	Mus musculus	0-27
34773993-3	2021	Here, we aimed to investigate the therapeutic effect of FGF21 in salt-sensitive hypertension-induced nephropathy.	Salts	65-69	fibroblast growth factor 21	Mus musculus	56-61
34773993-4	2021	METHODS: Changes of FGF21 expression in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mice were detected.	Desoxycorticosterone Acetate	40-67	fibroblast growth factor 21	Mus musculus	20-25
34773993-4	2021	METHODS: Changes of FGF21 expression in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mice were detected.	Desoxycorticosterone Acetate	69-73	fibroblast growth factor 21	Mus musculus	20-25
34773993-4	2021	METHODS: Changes of FGF21 expression in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mice were detected.	Salts	75-79	fibroblast growth factor 21	Mus musculus	20-25
34773993-8	2021	RESULTS: We observed significant elevation in circulating levels and renal expression of FGF21 in DOCA-salt-induced hypertensive mice.	doca-salt	98-107	fibroblast growth factor 21	Mus musculus	89-94
34773993-9	2021	We found that deletion of FGF21 in mice aggravated DOCA-salt-induced nephropathy.	doca-salt	51-60	fibroblast growth factor 21	Mus musculus	26-31
34774847-6	2022	Most importantly, fibroblast growth factor 21 (Fgf21) mRNA was significantly increased in the livers of alcohol-fed L1LKO mice compared to the alcohol-fed L1FLX group.	Alcohols	104-111	fibroblast growth factor 21	Mus musculus	18-45
34774847-6	2022	Most importantly, fibroblast growth factor 21 (Fgf21) mRNA was significantly increased in the livers of alcohol-fed L1LKO mice compared to the alcohol-fed L1FLX group.	Alcohols	104-111	fibroblast growth factor 21	Mus musculus	47-52
34774847-6	2022	Most importantly, fibroblast growth factor 21 (Fgf21) mRNA was significantly increased in the livers of alcohol-fed L1LKO mice compared to the alcohol-fed L1FLX group.	Alcohols	143-150	fibroblast growth factor 21	Mus musculus	18-45
34774847-6	2022	Most importantly, fibroblast growth factor 21 (Fgf21) mRNA was significantly increased in the livers of alcohol-fed L1LKO mice compared to the alcohol-fed L1FLX group.	Alcohols	143-150	fibroblast growth factor 21	Mus musculus	47-52
34774847-10	2022	Our results demonstrate that ZFP36L1 inactivation protects against alcohol-induced hepatic steatosis and liver injury and inflammation, possibly by stabilizing Fgf21 mRNA.	Alcohols	67-74	fibroblast growth factor 21	Mus musculus	160-165
34647525-9	2021	At the molecular level, exposure to ALAN concurrent with LP diet increased the expression of Phosphoenolpyruvate carboxykinase 1 in both periods analyzed and inverted the pattern of Fibroblast growth factor 21 (Fgf21) expression in the liver.	alan	36-40	fibroblast growth factor 21	Mus musculus	182-209
34647525-9	2021	At the molecular level, exposure to ALAN concurrent with LP diet increased the expression of Phosphoenolpyruvate carboxykinase 1 in both periods analyzed and inverted the pattern of Fibroblast growth factor 21 (Fgf21) expression in the liver.	alan	36-40	fibroblast growth factor 21	Mus musculus	211-216
34647525-10	2021	Our data suggest that dietary protein restriction modulates the effects induced by nighttime light exposure on glucose metabolism, which could be partially related with the dysregulation on hepatic Fgf21 expression.	Glucose	111-118	fibroblast growth factor 21	Mus musculus	198-203
34748822-1	2021	Fibroblast growth factor (Fgf/FGF) 21, which plays important roles in sugar, lipid and energy metabolism, has been accepted as a mito-stress marker gene.	Sugars	70-75	fibroblast growth factor 21	Mus musculus	30-37
34748822-6	2021	The studies were designed to determine the regulation of Fgf/FGF21 expression by CDDP, and to characterize the underlying mechanisms of its regulation, as well as to determine the impact of gain or loss of Fgf/FGF21 function on the progression of CDDP hepatotoxicity.	Cisplatin	81-85	fibroblast growth factor 21	Mus musculus	61-66
34748822-7	2021	Our results showed that CDDP and phorbol ester induced mRNA and protein expression of Fgf/FGF21 and beta-Klotho, two essential components of Fgf21 signaling, in mouse livers and cultured mouse/human hepatocytes.	Cisplatin	24-28	fibroblast growth factor 21	Mus musculus	90-95
34748822-7	2021	Our results showed that CDDP and phorbol ester induced mRNA and protein expression of Fgf/FGF21 and beta-Klotho, two essential components of Fgf21 signaling, in mouse livers and cultured mouse/human hepatocytes.	Cisplatin	24-28	fibroblast growth factor 21	Mus musculus	141-146
34748822-7	2021	Our results showed that CDDP and phorbol ester induced mRNA and protein expression of Fgf/FGF21 and beta-Klotho, two essential components of Fgf21 signaling, in mouse livers and cultured mouse/human hepatocytes.	Phorbol Esters	33-46	fibroblast growth factor 21	Mus musculus	90-95
34748822-7	2021	Our results showed that CDDP and phorbol ester induced mRNA and protein expression of Fgf/FGF21 and beta-Klotho, two essential components of Fgf21 signaling, in mouse livers and cultured mouse/human hepatocytes.	Phorbol Esters	33-46	fibroblast growth factor 21	Mus musculus	141-146
34748822-10	2021	In addition, CDDP produces more severe liver injury in Fgf21-null than wild-type mice.	Cisplatin	13-17	fibroblast growth factor 21	Mus musculus	55-60
34748822-11	2021	Pre-treatment of GR activator dexamethasone or AhR activator beta-Naphthoflavone, both of which can induce Fgf21 expression, attenuated CDDP-induced hepatotoxicity in vivo and in vitro.	Dexamethasone	30-43	fibroblast growth factor 21	Mus musculus	107-112
34748822-11	2021	Pre-treatment of GR activator dexamethasone or AhR activator beta-Naphthoflavone, both of which can induce Fgf21 expression, attenuated CDDP-induced hepatotoxicity in vivo and in vitro.	beta-Naphthoflavone	61-80	fibroblast growth factor 21	Mus musculus	107-112
34748822-13	2021	Gain of Fgf/FGF21 function attenuates the progression of CDDP hepatotoxicity, which may be considered clinically to improve CDDP therapy.	Cisplatin	57-61	fibroblast growth factor 21	Mus musculus	12-17
34748822-13	2021	Gain of Fgf/FGF21 function attenuates the progression of CDDP hepatotoxicity, which may be considered clinically to improve CDDP therapy.	Cisplatin	124-128	fibroblast growth factor 21	Mus musculus	12-17
34732847-1	2022	Fibroblast growth factor (FGF) 21 is an endocrine growth factor mainly secreted by the liver in response to a ketogenic diet and alcohol consumption.	Alcohols	129-136	fibroblast growth factor 21	Mus musculus	0-33
34732847-8	2022	Finally, in the skeletal muscle, FGF21 increased Glut4 and Mct2, a membrane protein that acts as a carrier for ketone bodies.	Ketone Bodies	111-124	fibroblast growth factor 21	Mus musculus	33-38
34957482-3	2021	Here, we demonstrate that hepatic p38 activation by MKK6 overexpression in the liver of mice induces severe liver steatosis, reduces fat mass, and elevates circulating fatty acid levels in a hepatic p38alpha- and FGF21-dependent manner.	Fatty Acids	168-178	fibroblast growth factor 21	Mus musculus	213-218
34626204-9	2021	Furthermore, tumor markers such as FGF21 and EPCAM are lowered following UGCG OE, which could be related to glucosylceramide (GlcCer) and lactosylceramide (LacCer) accumulation in glycosphingolipid-enriched microdomains (GEMs) and subsequently altered signaling protein phosphorylation.	Glucosylceramides	126-132	fibroblast growth factor 21	Mus musculus	35-40
34626204-9	2021	Furthermore, tumor markers such as FGF21 and EPCAM are lowered following UGCG OE, which could be related to glucosylceramide (GlcCer) and lactosylceramide (LacCer) accumulation in glycosphingolipid-enriched microdomains (GEMs) and subsequently altered signaling protein phosphorylation.	CDw17 antigen	138-154	fibroblast growth factor 21	Mus musculus	35-40
34626204-9	2021	Furthermore, tumor markers such as FGF21 and EPCAM are lowered following UGCG OE, which could be related to glucosylceramide (GlcCer) and lactosylceramide (LacCer) accumulation in glycosphingolipid-enriched microdomains (GEMs) and subsequently altered signaling protein phosphorylation.	CDw17 antigen	156-162	fibroblast growth factor 21	Mus musculus	35-40
34626204-9	2021	Furthermore, tumor markers such as FGF21 and EPCAM are lowered following UGCG OE, which could be related to glucosylceramide (GlcCer) and lactosylceramide (LacCer) accumulation in glycosphingolipid-enriched microdomains (GEMs) and subsequently altered signaling protein phosphorylation.	Glycosphingolipids	180-197	fibroblast growth factor 21	Mus musculus	35-40
34675006-3	2021	Here, we demonstrate that hepatic p38 activation by MKK6 overexpression in the liver of mice induces severe liver steatosis, reduces fat mass, and elevates circulating fatty acid levels in a hepatic p38alpha- and FGF21-dependent manner.	Fatty Acids	168-178	fibroblast growth factor 21	Mus musculus	213-218
34675006-4	2021	Mechanistically, through increasing the FGF21 production from liver, hepatic p38 activation increases the influx of fatty acids from adipose tissue to liver, leading to hepatic ectopic lipid accumulation and insulin resistance.	Fatty Acids	116-127	fibroblast growth factor 21	Mus musculus	40-45
34626204-9	2021	Furthermore, tumor markers such as FGF21 and EPCAM are lowered following UGCG OE, which could be related to glucosylceramide (GlcCer) and lactosylceramide (LacCer) accumulation in glycosphingolipid-enriched microdomains (GEMs) and subsequently altered signaling protein phosphorylation.	Glucosylceramides	108-124	fibroblast growth factor 21	Mus musculus	35-40
34957482-4	2021	Mechanistically, through increasing the FGF21 production from liver, hepatic p38 activation increases the influx of fatty acids from adipose tissue to liver, leading to hepatic ectopic lipid accumulation and insulin resistance.	Fatty Acids	116-127	fibroblast growth factor 21	Mus musculus	40-45
34449315-1	2021	Fibroblast growth factor 21 (FGF21) acts as an endocrine factor, playing important roles in the regulation of energy homeostasis, glucose and lipid metabolism.	Glucose	130-137	fibroblast growth factor 21	Mus musculus	0-27
34708083-9	2021	Consistently, in vitro study also demonstrated that Fgf21 blocked the upregulation of collagen by Tgf-beta in fibroblasts and attenuated tachypacing-induced oxidative stress including reactive oxygen species (ROS), Tgf-beta, and ox-CaMKII in atrial myocytes.	Reactive Oxygen Species	184-207	fibroblast growth factor 21	Mus musculus	52-57
34708083-9	2021	Consistently, in vitro study also demonstrated that Fgf21 blocked the upregulation of collagen by Tgf-beta in fibroblasts and attenuated tachypacing-induced oxidative stress including reactive oxygen species (ROS), Tgf-beta, and ox-CaMKII in atrial myocytes.	Reactive Oxygen Species	209-212	fibroblast growth factor 21	Mus musculus	52-57
34708083-11	2021	Fgf21 also improved tachypacing-induced myofibril degradation, downregulation of L-type calcium channel, and upregulation of p-RyR2, which implicated protective effects of Fgf21 on structural and electrical remodeling in the atria.	Calcium	88-95	fibroblast growth factor 21	Mus musculus	0-5
34708083-11	2021	Fgf21 also improved tachypacing-induced myofibril degradation, downregulation of L-type calcium channel, and upregulation of p-RyR2, which implicated protective effects of Fgf21 on structural and electrical remodeling in the atria.	Calcium	88-95	fibroblast growth factor 21	Mus musculus	172-177
34406362-3	2021	Glucose supplementation during the anorectic period induced by bacterial inflammation suppresses adaptive fasting metabolic pathways, including fibroblast growth factor 21 (FGF21), and decreases survival.	Glucose	0-7	fibroblast growth factor 21	Mus musculus	144-171
34406362-3	2021	Glucose supplementation during the anorectic period induced by bacterial inflammation suppresses adaptive fasting metabolic pathways, including fibroblast growth factor 21 (FGF21), and decreases survival.	Glucose	0-7	fibroblast growth factor 21	Mus musculus	173-178
34265279-2	2021	The PPARalpha-FGF21 axis protects against alcohol-related liver disease (ALD).	Alcohols	42-49	fibroblast growth factor 21	Mus musculus	14-19
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	oleanolic acid 3-acetate	121-145	fibroblast growth factor 21	Mus musculus	81-86
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	oleanolic acid 3-acetate	121-145	fibroblast growth factor 21	Mus musculus	223-228
34449315-1	2021	Fibroblast growth factor 21 (FGF21) acts as an endocrine factor, playing important roles in the regulation of energy homeostasis, glucose and lipid metabolism.	Glucose	130-137	fibroblast growth factor 21	Mus musculus	29-34
34449315-4	2021	In the present study, we found that 3-O-acetyloleanolic acid, an active constituent isolated from the fruits of Forsythia suspensa, stimulated FGF21 production concomitant with the up-regulation of a transcription factor, nuclear receptor Nr4a1, in C2C12 myotubes.	oleanolic acid 3-acetate	36-60	fibroblast growth factor 21	Mus musculus	143-148
34449315-5	2021	Additionally, significant increases in mFgf21 promoter activity were observed in C2C12 cells overexpressing TGR5 receptor in response to 3-O-acetyloleanolic acid treatment.	oleanolic acid 3-acetate	137-161	fibroblast growth factor 21	Mus musculus	39-45
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	SB 203580	18-26	fibroblast growth factor 21	Mus musculus	56-61
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	SB 203580	18-26	fibroblast growth factor 21	Mus musculus	81-86
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	SB 203580	18-26	fibroblast growth factor 21	Mus musculus	223-228
34449315-7	2021	Pretreatment with SB203580 also significantly repressed FGF21 mRNA abundance and FGF21 secretion in C2C12 myotubes after 3-O-acetyloleanolic acid stimulation, suggesting that p38 activation is required for the induction of FGF21 by ligand-activated TGR5 in C2C12 myotubes.	oleanolic acid 3-acetate	121-145	fibroblast growth factor 21	Mus musculus	56-61
34264867-0	2021	The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis.	Acetylcholine	21-34	fibroblast growth factor 21	Mus musculus	15-20
34638898-3	2021	The aim of this study was to compare the effects of FGF21 on food preferences and glucose and lipid metabolism in C57Bl/6J male and female mice with diet-induced obesity.	Glucose	82-89	fibroblast growth factor 21	Mus musculus	52-57
34638898-7	2021	FGF21 administration decreased adiposity; blood levels of cholesterol, glucose, and insulin; hypothalamic Agrp expression, increased SD intake, decreased HFD intake independently of sex, and increased WAT expression of Pparg, Lpl and Lipe only in females.	Cholesterol	58-69	fibroblast growth factor 21	Mus musculus	0-5
34638898-7	2021	FGF21 administration decreased adiposity; blood levels of cholesterol, glucose, and insulin; hypothalamic Agrp expression, increased SD intake, decreased HFD intake independently of sex, and increased WAT expression of Pparg, Lpl and Lipe only in females.	Glucose	71-78	fibroblast growth factor 21	Mus musculus	0-5
34060628-8	2021	Mechanistically, spermidine increases the hepatokine FGF21 expression in liver without reducing food intake.	Spermidine	17-27	fibroblast growth factor 21	Mus musculus	53-58
34060628-9	2021	Spermidine also modulates FGF21 in adipose tissues, elevating FGF21 expression in subcutaneous fat, but reducing it in visceral fat.	Spermidine	0-10	fibroblast growth factor 21	Mus musculus	26-31
34060628-9	2021	Spermidine also modulates FGF21 in adipose tissues, elevating FGF21 expression in subcutaneous fat, but reducing it in visceral fat.	Spermidine	0-10	fibroblast growth factor 21	Mus musculus	62-67
34264867-9	2021	Our study reveals a key role of the miR-182-5p/FGF21/acetylcholine/acetylcholine receptor 14 axis that mediates the crosstalk between adipocytes and macrophages to promote beige fat 15 thermogenesis.	Acetylcholine	53-66	fibroblast growth factor 21	Mus musculus	47-52
34472154-5	2021	Central administration of FGF21 increased the number of tyrosine hydroxylase-positive catecholaminergic cells expressing c-Fos protein, an activity marker of neurones, in the nucleus tractus solitarius and area postrema.	Tyrosine	56-64	fibroblast growth factor 21	Mus musculus	26-31
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	Polymers	89-96	fibroblast growth factor 21	Mus musculus	23-28
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	Polymers	89-96	fibroblast growth factor 21	Mus musculus	52-57
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	Polyethyleneimine	97-100	fibroblast growth factor 21	Mus musculus	23-28
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	perflutren	15-31	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	perflutren	33-37	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	Polyethyleneimine	43-59	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	Polyethyleneimine	61-64	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	Polyethyleneimine	61-64	fibroblast growth factor 21	Mus musculus	216-228
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	Polyethyleneimine	97-100	fibroblast growth factor 21	Mus musculus	52-57
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	Polylactic Acid-Polyglycolic Acid Copolymer	72-102	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	Polylactic Acid-Polyglycolic Acid Copolymer	72-102	fibroblast growth factor 21	Mus musculus	216-228
34229476-6	2021	Results from our luciferase-reporter assay and chromatin immunoprecipitation suggest that evolutionarily conserved TCF binding motifs (TCFBs) on Fgf21 promoter mediate Wnt-3a induced Fgf21 transactivation.	tcf	115-118	fibroblast growth factor 21	Mus musculus	145-150
34229476-6	2021	Results from our luciferase-reporter assay and chromatin immunoprecipitation suggest that evolutionarily conserved TCF binding motifs (TCFBs) on Fgf21 promoter mediate Wnt-3a induced Fgf21 transactivation.	tcf	115-118	fibroblast growth factor 21	Mus musculus	183-188
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polyethyleneimine	43-59	fibroblast growth factor 21	Mus musculus	141-153
34229476-8	2021	Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15.	Estradiol	17-26	fibroblast growth factor 21	Mus musculus	51-56
34229476-8	2021	Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15.	Estradiol	17-26	fibroblast growth factor 21	Mus musculus	127-132
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polyethyleneimine	61-64	fibroblast growth factor 21	Mus musculus	134-139
34229476-8	2021	Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15.	Estradiol	28-30	fibroblast growth factor 21	Mus musculus	51-56
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	cppnbs	123-129	fibroblast growth factor 21	Mus musculus	184-189
34129954-5	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed (CPPNBs@FGF21) via the electrostatic incorporation effect.	cppnbs	123-129	fibroblast growth factor 21	Mus musculus	216-228
34229476-8	2021	Finally, in MPH, estradiol (E2) treatment enhanced FGF21 expression, as well as binding of TCF7L2 and RNA polymerase II to the Fgf21 promoter; and the enhancement can be attenuated by the G-protein-coupled estrogen receptor 1 (GPER) antagonist G15.	Estradiol	28-30	fibroblast growth factor 21	Mus musculus	127-132
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polyethyleneimine	61-64	fibroblast growth factor 21	Mus musculus	141-153
34129954-6	2021	CPPNBs@FGF21 could effectively deliver FGF21 to the myocardial tissue through the cavitation effect under low-frequency ultrasound (LFUS).	cppnbs	0-6	fibroblast growth factor 21	Mus musculus	7-12
34129954-6	2021	CPPNBs@FGF21 could effectively deliver FGF21 to the myocardial tissue through the cavitation effect under low-frequency ultrasound (LFUS).	cppnbs	0-6	fibroblast growth factor 21	Mus musculus	39-44
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polylactic Acid-Polyglycolic Acid Copolymer	72-102	fibroblast growth factor 21	Mus musculus	134-139
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	cppnbs	16-22	fibroblast growth factor 21	Mus musculus	23-28
34129954-7	2021	The as-prepared CPPNBs@FGF21 could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety.	cppnbs	16-22	fibroblast growth factor 21	Mus musculus	52-57
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polylactic Acid-Polyglycolic Acid Copolymer	72-102	fibroblast growth factor 21	Mus musculus	141-153
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polylactic Acid-Polyglycolic Acid Copolymer	104-108	fibroblast growth factor 21	Mus musculus	134-139
34129954-13	2021	In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 (CPPNBs@FGF21) were developed for the prophylactic treatment of DCM.	Polylactic Acid-Polyglycolic Acid Copolymer	104-108	fibroblast growth factor 21	Mus musculus	141-153
34129954-14	2021	CPPNBs@FGF21 could effectively deliver the FGF21 to the myocardial tissue through the cavitation effect of low-frequency ultrasound (LFUS).	cppnbs	0-6	fibroblast growth factor 21	Mus musculus	7-12
34129954-14	2021	CPPNBs@FGF21 could effectively deliver the FGF21 to the myocardial tissue through the cavitation effect of low-frequency ultrasound (LFUS).	cppnbs	0-6	fibroblast growth factor 21	Mus musculus	43-48
34360670-2	2021	We aimed to investigate the FGF21 response in an ethanol-induced acute-on-chronic liver injury (ACLI) model in Abcb4-/- mice with deficiency of the hepatobiliary phospholipid transporter.	Ethanol	49-56	fibroblast growth factor 21	Mus musculus	28-33
34227742-5	2021	Further study revealed that the glucose metabolite sensor carbohydrate-response element-binding protein (ChREBP) was activated in the highly glycolytic muscle and stimulated the elevation of plasma fibroblast growth factor 21 (FGF21), possibly mediating enhanced lipid oxidation in adipose tissue and contributing to a systemic effect.	Glucose	32-39	fibroblast growth factor 21	Mus musculus	198-225
34227742-5	2021	Further study revealed that the glucose metabolite sensor carbohydrate-response element-binding protein (ChREBP) was activated in the highly glycolytic muscle and stimulated the elevation of plasma fibroblast growth factor 21 (FGF21), possibly mediating enhanced lipid oxidation in adipose tissue and contributing to a systemic effect.	Glucose	32-39	fibroblast growth factor 21	Mus musculus	227-232
34360670-7	2021	RESULTS: Alcohol feeding significantly induced plasma FGF21 and decreased hepatic Cyp7a1 levels.	Alcohols	9-16	fibroblast growth factor 21	Mus musculus	54-59
34158480-1	2021	Chronic dietary protein-restriction can create essential amino acid deficiencies and induce metabolic adaptation through the hepatic FGF21 pathway which serves to maintain host fitness during prolonged states of nutritional imbalance.	Amino Acids, Essential	47-67	fibroblast growth factor 21	Mus musculus	133-138
34192547-6	2021	Mechanistically, we show that beta-adrenergic stimulation of thermogenic gene expression requires FGF21 in adipocytes to promote phosphorylation of phospholipase C-gamma and mobilization of intracellular calcium.	Calcium	204-211	fibroblast growth factor 21	Mus musculus	98-103
34192547-7	2021	Moreover, we find that the beta-adrenergic-dependent increase in circulating FGF21 occurs through an indirect mechanism in which fatty acids released by adipocyte lipolysis subsequently activate hepatic PPARalpha to increase FGF21 expression.	Fatty Acids	129-140	fibroblast growth factor 21	Mus musculus	77-82
34192547-7	2021	Moreover, we find that the beta-adrenergic-dependent increase in circulating FGF21 occurs through an indirect mechanism in which fatty acids released by adipocyte lipolysis subsequently activate hepatic PPARalpha to increase FGF21 expression.	Fatty Acids	129-140	fibroblast growth factor 21	Mus musculus	225-230
34141985-0	2021	Fructose Protects Against Acetaminophen-Induced Hepatotoxicity Mainly by Activating the Carbohydrate-Response Element-Binding Protein alpha-Fibroblast Growth Factor 21 Axis in Mice.	Fructose	0-8	fibroblast growth factor 21	Mus musculus	140-167
34064590-10	2021	The mechanism underlying the LPHF-induced loss of body weight and WAT may be attributed to the synergistically upregulated expression of Ucp1 in WAT and Fgf21 in the liver, which may enhance energy expenditure.	lphf	29-33	fibroblast growth factor 21	Mus musculus	153-158
34141985-0	2021	Fructose Protects Against Acetaminophen-Induced Hepatotoxicity Mainly by Activating the Carbohydrate-Response Element-Binding Protein alpha-Fibroblast Growth Factor 21 Axis in Mice.	Acetaminophen	26-39	fibroblast growth factor 21	Mus musculus	140-167
34141985-0	2021	Fructose Protects Against Acetaminophen-Induced Hepatotoxicity Mainly by Activating the Carbohydrate-Response Element-Binding Protein alpha-Fibroblast Growth Factor 21 Axis in Mice.	Carbohydrates	88-100	fibroblast growth factor 21	Mus musculus	140-167
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Fructose	24-32	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Fructose	24-32	fibroblast growth factor 21	Mus musculus	282-287
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	4-amino-N-acetyl-N-methylaniline	53-57	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	4-amino-N-acetyl-N-methylaniline	53-57	fibroblast growth factor 21	Mus musculus	282-287
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Fructose	72-80	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Fructose	72-80	fibroblast growth factor 21	Mus musculus	282-287
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	4-amino-N-acetyl-N-methylaniline	94-98	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	4-amino-N-acetyl-N-methylaniline	94-98	fibroblast growth factor 21	Mus musculus	282-287
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	4-amino-N-acetyl-N-methylaniline	117-121	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Carbohydrates	187-199	fibroblast growth factor 21	Mus musculus	253-280
34141985-4	2021	We found that both high-fructose diet feeding before APAP injection and fructose gavage after APAP injection reduced APAP-induced liver injury with a concomitant induction of the hepatic carbohydrate-response element-binding protein alpha (ChREBPalpha)-fibroblast growth factor 21 (FGF21) pathway.	Carbohydrates	187-199	fibroblast growth factor 21	Mus musculus	282-287
34141985-7	2021	Furthermore, overexpression of FGF21 in the liver was sufficient to reverse liver toxicity in APAP-injected Chrebpalpha-LKO mice.	4-amino-N-acetyl-N-methylaniline	94-98	fibroblast growth factor 21	Mus musculus	31-36
34141985-8	2021	Conclusion: Fructose protects against APAP-induced hepatotoxicity likely through its ability to activate the hepatocyte ChREBPalpha-FGF21 axis.	Fructose	12-20	fibroblast growth factor 21	Mus musculus	132-137
34141985-8	2021	Conclusion: Fructose protects against APAP-induced hepatotoxicity likely through its ability to activate the hepatocyte ChREBPalpha-FGF21 axis.	4-amino-N-acetyl-N-methylaniline	38-42	fibroblast growth factor 21	Mus musculus	132-137
35418153-0	2022	Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet.	epigallocatechin gallate	0-26	fibroblast growth factor 21	Mus musculus	66-71
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	194-199
35605662-5	2022	In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes.	Seladelpar	13-23	fibroblast growth factor 21	Mus musculus	36-63
35605662-5	2022	In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes.	Seladelpar	13-23	fibroblast growth factor 21	Mus musculus	65-70
35605662-7	2022	The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1.	Seladelpar	26-36	fibroblast growth factor 21	Mus musculus	141-146
35628302-0	2022	Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.	Pyruvic Acid	0-8	fibroblast growth factor 21	Mus musculus	29-34
35628302-0	2022	Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.	Cyclic AMP	79-83	fibroblast growth factor 21	Mus musculus	29-34
35628302-1	2022	Fibroblast growth factor 21 (FGF21) functions as a polypeptide hormone to regulate glucose and lipid metabolism, and its expression is regulated by cellular metabolic stress.	Glucose	83-90	fibroblast growth factor 21	Mus musculus	0-27
35628302-1	2022	Fibroblast growth factor 21 (FGF21) functions as a polypeptide hormone to regulate glucose and lipid metabolism, and its expression is regulated by cellular metabolic stress.	Glucose	83-90	fibroblast growth factor 21	Mus musculus	29-34
35628302-3	2022	However, the effect of pyruvate on hepatic FGF21 expression and secretion remains unknown.	Pyruvic Acid	23-31	fibroblast growth factor 21	Mus musculus	43-48
35628302-5	2022	In HepG2 and AML12 cells, pyruvate at concentrations above 0.1 mM significantly increased FGF21 expression and secretion.	Pyruvic Acid	26-34	fibroblast growth factor 21	Mus musculus	90-95
35628302-6	2022	The increase in cellular cAMP levels by adenylyl cyclase activation, phosphodiesterase (PDE) inhibition and 8-Bromo-cAMP administration significantly restrained pyruvate-stimulated FGF21 expression.	Cyclic AMP	25-29	fibroblast growth factor 21	Mus musculus	181-186
35628302-6	2022	The increase in cellular cAMP levels by adenylyl cyclase activation, phosphodiesterase (PDE) inhibition and 8-Bromo-cAMP administration significantly restrained pyruvate-stimulated FGF21 expression.	8-Bromo Cyclic Adenosine Monophosphate	108-120	fibroblast growth factor 21	Mus musculus	181-186
35628302-6	2022	The increase in cellular cAMP levels by adenylyl cyclase activation, phosphodiesterase (PDE) inhibition and 8-Bromo-cAMP administration significantly restrained pyruvate-stimulated FGF21 expression.	Pyruvic Acid	161-169	fibroblast growth factor 21	Mus musculus	181-186
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Cyclic AMP	57-61	fibroblast growth factor 21	Mus musculus	130-135
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Cyclic AMP	57-61	fibroblast growth factor 21	Mus musculus	188-193
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Pyruvic Acid	159-167	fibroblast growth factor 21	Mus musculus	130-135
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Pyruvic Acid	159-167	fibroblast growth factor 21	Mus musculus	188-193
35628302-9	2022	The increase in plasma pyruvate levels in mice induced by the intraperitoneal injection of pyruvate significantly increased FGF21 gene expression and PDE activity with a reduction in cAMP levels and CREB phosphorylation in the mouse liver compared with the control.	Pyruvic Acid	23-31	fibroblast growth factor 21	Mus musculus	124-129
35628302-9	2022	The increase in plasma pyruvate levels in mice induced by the intraperitoneal injection of pyruvate significantly increased FGF21 gene expression and PDE activity with a reduction in cAMP levels and CREB phosphorylation in the mouse liver compared with the control.	Pyruvic Acid	91-99	fibroblast growth factor 21	Mus musculus	124-129
35628302-10	2022	In conclusion, pyruvate activates PDEs to reduce cAMP and then inhibits the cAMP-Epac-CREB signaling pathway to upregulate FGF21 expression in hepatocytes.	Pyruvic Acid	15-23	fibroblast growth factor 21	Mus musculus	123-128
35628302-10	2022	In conclusion, pyruvate activates PDEs to reduce cAMP and then inhibits the cAMP-Epac-CREB signaling pathway to upregulate FGF21 expression in hepatocytes.	Cyclic AMP	76-80	fibroblast growth factor 21	Mus musculus	123-128
35513524-7	2022	Fgf21-/- mice but not cmFgf21-/- mice had unexpectedly higher serum betaOHB levels, and higher expression levels of PPARalpha and oxidative stress response genes than WT mice or Fgf21fl/fl littermates.	betaohb	68-75	fibroblast growth factor 21	Mus musculus	0-5
34654875-0	2022	Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway.	sulforaphane	0-12	fibroblast growth factor 21	Mus musculus	80-85
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	75-102
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	104-109
35605662-0	2022	Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway.	Seladelpar	28-38	fibroblast growth factor 21	Mus musculus	108-135
35534765-7	2022	JQ-R induces these changes along with FGFR1 phosphorylation, which was also detected in JQ-R treated FGF21 knockout mice.	jq-r	0-4	fibroblast growth factor 21	Mus musculus	101-106
35534765-7	2022	JQ-R induces these changes along with FGFR1 phosphorylation, which was also detected in JQ-R treated FGF21 knockout mice.	jq-r	88-92	fibroblast growth factor 21	Mus musculus	101-106
35418153-0	2022	Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet.	epigallocatechin gallate	0-26	fibroblast growth factor 21	Mus musculus	100-105
35418153-9	2022	Meanwhile EGCG alleviated FGF21 resistance and elevated FGFR/AMPK expression, which suggested an unrecognized mechanism of EGCG in ameliorating NAFLD.	epigallocatechin gallate	10-14	fibroblast growth factor 21	Mus musculus	26-31
35418153-9	2022	Meanwhile EGCG alleviated FGF21 resistance and elevated FGFR/AMPK expression, which suggested an unrecognized mechanism of EGCG in ameliorating NAFLD.	epigallocatechin gallate	123-127	fibroblast growth factor 21	Mus musculus	26-31
35418153-10	2022	CONCLUSIONS: EGCG attenuated hepatocytes damage and dysfunction in NAFLD by alleviating FGF21 resistance and improve FGFR/AMPK pathway, mitigating oxidative stress.	epigallocatechin gallate	13-17	fibroblast growth factor 21	Mus musculus	88-93
35363898-11	2022	Mechanistically, SBK1 phosphorylates the orphan Nuclear Receptor 4A1 (Nur77) on serine 344 to promote hepatic FGF21 expression and inhibit the transcription of genes involved in lipid anabolism.	Serine	80-86	fibroblast growth factor 21	Mus musculus	110-115
34984826-4	2022	Here, we verified the relationship among FGF21, autophagy and SIRT1 in carbon tetrachloride (CCl4 )-induced ALI.	Carbon Tetrachloride	71-91	fibroblast growth factor 21	Mus musculus	41-46
35107741-13	2022	CONCLUSION: These findings indicated that long-term ADF protects mouse livers against HFD induced fatty liver disease through controlling PPARalpha/Fgf21 signaling.	ADF	52-55	fibroblast growth factor 21	Mus musculus	148-153
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	16-19	fibroblast growth factor 21	Mus musculus	93-98
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	16-19	fibroblast growth factor 21	Mus musculus	152-157
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	24-27	fibroblast growth factor 21	Mus musculus	93-98
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	24-27	fibroblast growth factor 21	Mus musculus	152-157
35163722-8	2022	Moreover, taurine upregulated Cyp7a1 levels, while downregulated phosphorylated ERK and Fgf21 levels in the liver.	Taurine	10-17	fibroblast growth factor 21	Mus musculus	88-93
35163722-9	2022	Likewise, taurine-treated Hepa1-6 cells, a mouse hepatocyte line, exhibited downregulated Fgf21 levels and upregulated promoter activity of Cyp7a1.	Taurine	10-17	fibroblast growth factor 21	Mus musculus	90-95
35163722-10	2022	These results indicate that taurine promotes cholesterol metabolism by suppressing the FGF21/ERK pathway followed by upregulating Cyp7a1 expression.	Taurine	28-35	fibroblast growth factor 21	Mus musculus	87-92
35163722-10	2022	These results indicate that taurine promotes cholesterol metabolism by suppressing the FGF21/ERK pathway followed by upregulating Cyp7a1 expression.	Cholesterol	45-56	fibroblast growth factor 21	Mus musculus	87-92
35232994-4	2022	By using antisense oligonucleotides (ASO) and genetic depletion of Mat1a, here, we demonstrate that Mat1a deficiency in diet-induce obese or genetically obese mice prevented and reversed obesity and obesity-associated insulin resistance and hepatosteatosis by increasing energy expenditure in a hepatocyte FGF21 dependent fashion.	Oligonucleotides, Antisense	37-40	fibroblast growth factor 21	Mus musculus	306-311
35434487-0	2022	Estradiol-dependent and independent effects of FGF21 in obese female mice.	Estradiol	0-9	fibroblast growth factor 21	Mus musculus	47-52
35434487-7	2022	The objec tive of this study was to study the inf luence of FGF21 on metabolic characteristics, food intake, and the expression of carbohydrate and fat metabolism genes in the liver, adipose tissue, and hypothalamus in female mice with alimentary obesity and low (ovariectomy) or high (ovariectomy + E2) blood estradiol level.	Carbohydrates	131-143	fibroblast growth factor 21	Mus musculus	60-65
35434487-7	2022	The objec tive of this study was to study the inf luence of FGF21 on metabolic characteristics, food intake, and the expression of carbohydrate and fat metabolism genes in the liver, adipose tissue, and hypothalamus in female mice with alimentary obesity and low (ovariectomy) or high (ovariectomy + E2) blood estradiol level.	Estradiol	310-319	fibroblast growth factor 21	Mus musculus	60-65
35434487-10	2022	In OVX obese females, FGF21, regardless of E2-treatment, did not affect body weight, and adipose tissue weight, or glucose tolerance but increased the consumption of standard chow, reduced blood glucose levels, and suppressed its own expression in the liver (Fgf21), as well as the expression of the G6pc and Acacalpha genes.	Glucose	195-202	fibroblast growth factor 21	Mus musculus	22-27
35434487-11	2022	This study is the f irst to show the modif ication of FGF21 effects by estradiol: inhibition of FGF21-inf luence on the expression of Irs2 and Pklr in the liver and potentiation of the FGF21-stimulated expression of Lepr and Klb in the hypothalamus.	Estradiol	71-80	fibroblast growth factor 21	Mus musculus	54-59
35434487-11	2022	This study is the f irst to show the modif ication of FGF21 effects by estradiol: inhibition of FGF21-inf luence on the expression of Irs2 and Pklr in the liver and potentiation of the FGF21-stimulated expression of Lepr and Klb in the hypothalamus.	Estradiol	71-80	fibroblast growth factor 21	Mus musculus	96-101
35434487-11	2022	This study is the f irst to show the modif ication of FGF21 effects by estradiol: inhibition of FGF21-inf luence on the expression of Irs2 and Pklr in the liver and potentiation of the FGF21-stimulated expression of Lepr and Klb in the hypothalamus.	Estradiol	71-80	fibroblast growth factor 21	Mus musculus	185-190
35434487-12	2022	In addition, when administered together with estradiol, FGF21 exerted an inhibitory effect on the expression of Cpt1alpha in subcutaneous white adipose tissue (scWAT), whereas no stimulating FGF21 effects on the expression of Insr and Acacbeta in scWAT or inhibitory FGF21 effect on the plasma insulin level were observed.	Estradiol	45-54	fibroblast growth factor 21	Mus musculus	56-61
35434487-14	2022	However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.	Estradiol	9-18	fibroblast growth factor 21	Mus musculus	58-63
35434487-14	2022	However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.	Estradiol	9-18	fibroblast growth factor 21	Mus musculus	160-165
35434487-14	2022	However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.	Estradiol	9-18	fibroblast growth factor 21	Mus musculus	244-249
35202923-13	2022	The mRNA expressions of Fgf21 and Plin2 were significantly increased (P < 0.05) and the mRNA expressions of Cyp2b10, Cyp7a1, Per2 and Mylip were significantly decreased (P < 0.05) after arsenic induction.	Arsenic	186-193	fibroblast growth factor 21	Mus musculus	24-29
35163521-4	2022	High-fat and high-carbohydrate diets increase plasma 5-HT and fibroblast growth factor-21 (FGF21) levels.	Carbohydrates	18-30	fibroblast growth factor 21	Mus musculus	62-89
35163521-4	2022	High-fat and high-carbohydrate diets increase plasma 5-HT and fibroblast growth factor-21 (FGF21) levels.	Carbohydrates	18-30	fibroblast growth factor 21	Mus musculus	91-96
35163521-7	2022	Nutritional, pharmacologic, or genetic inhibition of peripheral 5-HT synthesis via tryptophan hydroxylase 1 (Tph1) decreases hepatic FGF21 expression and plasma FGF21 levels in mice.	Serotonin	64-68	fibroblast growth factor 21	Mus musculus	133-138
35163521-7	2022	Nutritional, pharmacologic, or genetic inhibition of peripheral 5-HT synthesis via tryptophan hydroxylase 1 (Tph1) decreases hepatic FGF21 expression and plasma FGF21 levels in mice.	Serotonin	64-68	fibroblast growth factor 21	Mus musculus	161-166
35163521-10	2022	Peripheral 5-HT upregulates hepatic FGF21 expression and plasma FGF21 levels, leading to metabolic diseases such as obesity, insulin resistance, type 2 diabetes, and NAFLD.	Serotonin	11-15	fibroblast growth factor 21	Mus musculus	36-41
35163521-10	2022	Peripheral 5-HT upregulates hepatic FGF21 expression and plasma FGF21 levels, leading to metabolic diseases such as obesity, insulin resistance, type 2 diabetes, and NAFLD.	Serotonin	11-15	fibroblast growth factor 21	Mus musculus	64-69
34986508-9	2022	In addition, transcriptome analyses uncovered that CNPY2 is also required for DEN-induced expression of oncogenes, including c-Jun and FGF21.	Diethylnitrosamine	78-81	fibroblast growth factor 21	Mus musculus	135-140