PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25956731-9	2015	The ERK, AKT, PKC, Rac-1 and ROCK2 pathways were involved in UTP-induced cell proliferation and migration, MMP-2 and HMGB1 secretion and RAGE expression in the IL-1beta-pretreated VSMCs.	Uridine Triphosphate	61-64	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-34
25956731-10	2015	UTP induced the phosphorylation of ERK, AKT and PKC and the translocation of Rac-1 and ROCK2 from cytosol to membrane as well as stress fiber formation, which were markedly increased in the IL-1beta-pretreated VSMCs but not in the P2Y2R-siRNA-transfected VSMCs.	Uridine Triphosphate	0-3	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-92
25776136-2	2015	Our previous study indicated that PEG-PEI/siROCK2 could effectively suppress ROCK2 mRNA expression and showed a promising prospect for the treatment of Alzheimer"s disease.	poly(ethylene glycol)-co-poly(ethyleneimine)	34-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	44-49
25882521-0	2015	Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor"s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations.	Urea	34-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	45-49
26223433-8	2015	Although Fasudil inhibited both ROCK I and ROCK II, FSD-C10 more selectively suppressed ROCK II, but not ROCK I, which may be related to vasodilation insensitivity and animal mortality.	fasudil	9-16	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	43-50
25882521-0	2015	Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor"s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations.	Urea	34-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	100-105
25882521-3	2015	Computational results suggested that substitution containing positive charge attached to the middle phenyl ring, or electropositive group in urea linker was favored for both activity and ROCK2/PKA selectivity.	Urea	141-145	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	187-192
25964548-5	2015	RESULTS: Exposure to CAL-101 and celecoxib significantly increased apoptosis, which was accompanied by the inactivation of AKT, Ras homolog gene family, member A (RHOA), Rho-associated coiled-coil containing protein kinase 1 (ROCK1), and ROCK2 as well as up-regulation of Phosphatase and tensin homolog (PTEN).	idelalisib	21-28	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	238-243
25964548-5	2015	RESULTS: Exposure to CAL-101 and celecoxib significantly increased apoptosis, which was accompanied by the inactivation of AKT, Ras homolog gene family, member A (RHOA), Rho-associated coiled-coil containing protein kinase 1 (ROCK1), and ROCK2 as well as up-regulation of Phosphatase and tensin homolog (PTEN).	Celecoxib	33-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	238-243
25712521-0	2015	Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway.	Atorvastatin	0-12	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	113-117
25162437-6	2015	Rho-kinase (ROCK1 and ROCK2) belongs to the family of serine/threonine kinases and is an important downstream effector of the small GTP-binding protein RhoA.	Guanosine Triphosphate	132-135	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
26114862-4	2015	Chronic in vivo or acute ex vivo Lapatinib treatment also significantly attenuated diabetes-induced increases in phosphorylation of EGFR, ErbB2, ERK1/2, AKT, ROCK2 and IkB-alpha as well as normalized the reduced levels of phosphorylated FOXO3A, and eNOS (Ser1177) in the diabetic MVB.	Lapatinib	33-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	158-163
25712521-11	2015	In conclusion, atorvastatin prevented Ang II-induced rupture of HAEC monolayers by suppressing the ROCK signaling pathway.	Atorvastatin	15-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	99-103
25223373-2	2015	In this study, we observed the therapeutic potential of a novel Rho kinase (ROCK) inhibitor FaD-1, a fasudil derivative, and explored possible mechanism in MOG35-55-induced EAE.	fasudil	101-108	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	76-80
25755711-6	2015	Inhibition of ROCK1 and ROCK2 by Y-27632 significantly inhibits proliferation, migration, and invasion of LSCC cells.	Y 27632	33-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	24-29
24283930-8	2014	EXPERT OPINION: Although currently only one ROCK inhibitor (fasudil) is used as a drug, more drugs based on ROCK inhibition are expected to be advanced into market in the near future.	fasudil	60-67	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	44-48
25916120-4	2015	As it was shown by us previously, ouabain induces membrane blebbing and proteolitic cleavage of ROCK I and ROCK II via caspases in human umbilical endothelial cells.	Ouabain	34-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	107-114
25243430-4	2014	Liver sinusoidal endothelial cells were isolated, pretreated with 10 ng/mL LPS for 6 h, and treated with 10 muM Y27632 (ROCK-2 inhibitor) for 30 min and 10 nM ET-1 for 30 min.	Y 27632	112-118	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	120-126
25544168-0	2014	[Suppression of hepatocellular carcinoma invasion and metastasis by Rho-kinase inhibitor Fasudil through inhibition of BTBD7-ROCK2 signaling pathway].	fasudil	89-96	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	125-130
25544168-8	2014	RESULTS: In HCCLM3 cells treated with Fasudil, the invasion ability was significant decreased compared with the control group, concomitant with the down-regulated expression levels of BTBD7, RhoC and ROCK2 protein as well as the decreased activities of MMP2 and MMP9.	fasudil	38-45	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	200-205
25385601-3	2014	Pharmacological inhibition with KD025 or siRNA-mediated inhibition of ROCK2, but not ROCK1, significantly diminished STAT3 phosphorylation and binding to IL-17 and IL-21 promoters and reduced IFN regulatory factor 4 and nuclear hormone RAR-related orphan receptor gammat protein levels in T cells derived from healthy subjects or rheumatoid arthritis patients.	KD025	32-37	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
24604753-9	2014	Consistent with ROCK2 under-expression, microtubule acetylation was found to be increased with tuberin deficiency; this alteration was abrogated by rapamycin treatment and mimicked by HDAC6 inhibition.	Sirolimus	148-157	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	16-21
24703874-6	2014	Moreover, we present in vivo evidence that Src family kinase (SFK) activity is critical for PCP regulation in the auditory sensory epithelium and that PTK7-SFK signaling regulates tyrosine phosphorylation of junctional ROCK2.	Tyrosine	180-188	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	219-224
24642531-0	2014	Downregulation of ROCK2 through nanocomplex sensitizes the cytotoxic effect of temozolomide in U251 glioma cells.	Temozolomide	79-91	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
24642531-2	2014	Therefore, we designed the current study to determine whether the downregulation of ROCK2 would sensitize the cytotoxic effect of temozolomide (TMZ) in U251 cells.	Temozolomide	130-142	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	84-89
24642531-2	2014	Therefore, we designed the current study to determine whether the downregulation of ROCK2 would sensitize the cytotoxic effect of temozolomide (TMZ) in U251 cells.	Temozolomide	144-147	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	84-89
24610576-0	2014	Prostaglandin E(2)-dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2.	Dinoprostone	0-18	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	124-129
24610576-7	2014	Phosphoproteomic analysis of PGE2 /GPCR/PKA phosphosubstrates identified a unique, non-redundant, phosphorylated (>30-fold) site on rho-associated coiled coil-containing kinase 2 (ROCK2) at S1379.	Dinoprostone	29-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	135-181
24610576-7	2014	Phosphoproteomic analysis of PGE2 /GPCR/PKA phosphosubstrates identified a unique, non-redundant, phosphorylated (>30-fold) site on rho-associated coiled coil-containing kinase 2 (ROCK2) at S1379.	Dinoprostone	29-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	183-188
24610576-8	2014	Analysis of ROCK2 mutant behaviour (e.g. S1379A) in overexpression studies revealed that PGE2 -dependent phosphorylation of ROCK2 resulted in the inhibition of the kinase, since induced MLC phosphorylation was no longer blocked by PGE2 nor could PGE2 induce disassembly of stress fibres.	Dinoprostone	89-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	12-17
24610576-8	2014	Analysis of ROCK2 mutant behaviour (e.g. S1379A) in overexpression studies revealed that PGE2 -dependent phosphorylation of ROCK2 resulted in the inhibition of the kinase, since induced MLC phosphorylation was no longer blocked by PGE2 nor could PGE2 induce disassembly of stress fibres.	Dinoprostone	89-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	124-129
24610576-8	2014	Analysis of ROCK2 mutant behaviour (e.g. S1379A) in overexpression studies revealed that PGE2 -dependent phosphorylation of ROCK2 resulted in the inhibition of the kinase, since induced MLC phosphorylation was no longer blocked by PGE2 nor could PGE2 induce disassembly of stress fibres.	Dinoprostone	231-235	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	124-129
24610576-8	2014	Analysis of ROCK2 mutant behaviour (e.g. S1379A) in overexpression studies revealed that PGE2 -dependent phosphorylation of ROCK2 resulted in the inhibition of the kinase, since induced MLC phosphorylation was no longer blocked by PGE2 nor could PGE2 induce disassembly of stress fibres.	Dinoprostone	231-235	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	124-129
24610576-9	2014	Thus, PGE2 -dependent blockade of actomyosin fibre formation, characteristic of myofibroblasts, may be mediated through specific ROCK2 S1379 phosphorylation.	Dinoprostone	6-10	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	129-134
24065547-0	2013	Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2/moesin cascade.	Testosterone	0-12	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	78-84
24674677-10	2014	In conclusion, ROCK-II was activated in various lung cells of IPF patients along with oxidative stress detected by 8-isoPGF2alpha elevation.	8-epi-prostaglandin F2alpha	115-129	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	15-22
24528629-9	2014	ROCK-1 and ROCK-2 siRNA were transfected into Y79 cells with Lipofectamine 2000.	Lipofectamine	61-79	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	11-17
24405853-0	2014	Characterization of a modified ROCK2 protein that allows use of N6-ATP analogs for the identification of novel substrates.	n6-atp	64-70	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-36
24405853-3	2014	To aid in the search for new ROCK2 substrates, we have developed an analog-sensitive (AS) ROCK2 protein that allows the use of selective ATP analogs that are not efficiently utilized by other protein kinases.	Adenosine Triphosphate	137-140	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-34
24405853-3	2014	To aid in the search for new ROCK2 substrates, we have developed an analog-sensitive (AS) ROCK2 protein that allows the use of selective ATP analogs that are not efficiently utilized by other protein kinases.	Adenosine Triphosphate	137-140	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	90-95
24405853-4	2014	RESULTS: The analog sensitive protein, M160A ROCK2, was highly active and could phosphorylate proteins from a cellular homogenate with gamma32P-N6 (benzyl)ATP.	gamma32p-n6 (benzyl)atp	135-158	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	45-50
24065547-8	2013	The ROCK-2 inhibitor Y27632 or the transfection of ROCK-2 siRNA largely inhibited T-induced moesin expression and phosphorylation, indicating that ROCK-2 pathway is crucial for these effects.	Y 27632	21-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	4-10
24100445-6	2013	This resulted in ROCK-mediated phosphorylation of MYPT1 on threonine 853 (thr(853)), the disassociation of the catalytic subunit protein phosphatase 1delta (PP1delta) from MYPT1 and inhibition of basal MLCP activity.	Threonine	59-62	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	17-21
23479079-11	2013	Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes.	Sulfides	55-62	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	16-22
24100445-6	2013	This resulted in ROCK-mediated phosphorylation of MYPT1 on threonine 853 (thr(853)), the disassociation of the catalytic subunit protein phosphatase 1delta (PP1delta) from MYPT1 and inhibition of basal MLCP activity.	Threonine	59-68	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	17-21
23479079-11	2013	Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes.	Sulfides	68-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	16-22
23479079-11	2013	Both ROCK-1 and ROCK-2 (Rho kinases) were activated by sulfide, and sulfide-induced cell blebbing was suppressed by a ROCK inhibitor, suggesting that a Rho pathway is involved in sulfide-induced blebbing in lymphocytes.	Sulfides	68-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	16-22
22124782-1	2012	Linoleic acid (LA), a dietary unsaturated fatty acid, has been known to increase the expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) through the activation of nuclear factor-kappa B. Rho/Rho-kinase (ROCK) pathway mediates various cellular functions related to cardiovascular disease and affects the expression of ICAM-1.	Linoleic Acid	0-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	235-239
22842919-8	2012	Furthermore, Y-27632, an inhibitor of ROCK2, attenuated the Ang II-induced contraction of HASMCs by blocking the RhoA/ROCK2 signaling pathway which is involved in this contraction, and thus may be a major regulator involved in the basal maintenance of contractility in HASMCs.	Y 27632	13-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	38-43
22842919-8	2012	Furthermore, Y-27632, an inhibitor of ROCK2, attenuated the Ang II-induced contraction of HASMCs by blocking the RhoA/ROCK2 signaling pathway which is involved in this contraction, and thus may be a major regulator involved in the basal maintenance of contractility in HASMCs.	Y 27632	13-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	118-123
22842919-8	2012	Furthermore, Y-27632, an inhibitor of ROCK2, attenuated the Ang II-induced contraction of HASMCs by blocking the RhoA/ROCK2 signaling pathway which is involved in this contraction, and thus may be a major regulator involved in the basal maintenance of contractility in HASMCs.	hasmcs	90-96	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	38-43
22842919-8	2012	Furthermore, Y-27632, an inhibitor of ROCK2, attenuated the Ang II-induced contraction of HASMCs by blocking the RhoA/ROCK2 signaling pathway which is involved in this contraction, and thus may be a major regulator involved in the basal maintenance of contractility in HASMCs.	hasmcs	90-96	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	118-123
22691107-12	2012	Expression of calponin and ROCK-II proteins was reduced by BIX-01294 in a dose-dependent manner and BIX-01294 significantly increased global methylation level in the foetal PASMCs.	BIX 01294	59-68	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	27-34
22124782-5	2012	Y-27632, a ROCK inhibitor, suppressed ICAM-1 expression and phosphorylation of MYPT-1 induced by LA.	Y 27632	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	11-15
22521647-3	2012	Thereafter, Hidaka"s inhibitor HA1077 or Fasudil was conjugated with oligo-D-arginine resulting in the compound ARC-3002 revealing high affinity towards ROCK-II (K(d)=20 pM) and over 160-fold selectivity compared to PKAc.	fasudil	31-37	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	153-160
22389473-7	2012	ROCK-II activation turns into an over-expression of c-Jun and c-Fos that is required for E(2)-induced expression of PAI-1.	Estradiol	89-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
22521647-3	2012	Thereafter, Hidaka"s inhibitor HA1077 or Fasudil was conjugated with oligo-D-arginine resulting in the compound ARC-3002 revealing high affinity towards ROCK-II (K(d)=20 pM) and over 160-fold selectivity compared to PKAc.	fasudil	41-48	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	153-160
22521647-3	2012	Thereafter, Hidaka"s inhibitor HA1077 or Fasudil was conjugated with oligo-D-arginine resulting in the compound ARC-3002 revealing high affinity towards ROCK-II (K(d)=20 pM) and over 160-fold selectivity compared to PKAc.	oligo-d-arginine	69-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	153-160
21418517-5	2012	Several signalling inhibitors interfered with progesterone-induced FAK activation, including progesterone receptor (PR) antagonist ORG 31710, specific c-Src kinase inhibitor PP2, phosphatidylinosital-3 kinase (PI3K) inhibitor wortmannin as well as rho-associated kinase (ROCK-2) inhibitor Y27632.	Progesterone	46-58	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	271-277
20504226-3	2010	Additionally, an elevated invasion of ESCC cells by AMFR was reversed by rho-associated protein kinase 2 inhibitor Y-27632, suggesting that AMFR pathway promotes invasion of ESCC cells and may be a potential target for ESCC therapy.	Y 27632	115-122	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	73-104
21497405-3	2011	This ability has been primarily attributed to the local production of specific neurohumoral substances that can work in conjunction with calcium sensitization via signal transduction events associated with the Ras homolog gene family, member A (RhoA)/Rho-associated, coiled-coil containing protein kinase 2 (ROCK II) pathways.	Calcium	137-144	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	251-306
21497405-3	2011	This ability has been primarily attributed to the local production of specific neurohumoral substances that can work in conjunction with calcium sensitization via signal transduction events associated with the Ras homolog gene family, member A (RhoA)/Rho-associated, coiled-coil containing protein kinase 2 (ROCK II) pathways.	Calcium	137-144	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	308-315
21559451-10	2011	In addition, the presence of ROCK-2 inhibitor Y-27632 in the medium had no effect on increasing the expression of pluripotency markers Nanog and Oct4 or decreasing apoptosis or the level of p53.	Y 27632	46-53	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-35
21349713-2	2011	Herein, we report the development of a series of ROCK-II inhibitors based on 4-quinazolinone and quinazoline scaffolds.	4-hydroxyquinazoline	77-92	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-56
21349713-2	2011	Herein, we report the development of a series of ROCK-II inhibitors based on 4-quinazolinone and quinazoline scaffolds.	Quinazolines	97-108	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-56
21349713-3	2011	SAR studies at three positions of the quinazoline core led to the identification of analogs with high potency against ROCK-II and good selectivity over protein kinase A (PKA).	Quinazolines	38-49	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	118-125
21850162-16	2011	Y-39983 was several-fold more potent when compared with Y-27632 at inhibiting the phosphorylation of MYPT1 at either Thr853 or Thr696 commensurate with its greater potency at inhibiting the activity of human ROCK-I and ROCK-II enzymes.	Y-39983	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	219-226
22348083-1	2012	BACKGROUND: ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA.	Guanosine Triphosphate	95-98	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
22004718-0	2011	Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).	Indoles	30-37	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-74
22004718-0	2011	Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).	7-azaindole dimer	42-54	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-74
22004718-2	2011	Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47).	indole	79-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	108-112
22004718-2	2011	Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47).	indole	79-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	150-154
22004718-2	2011	Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47).	7-azaindole dimer	90-101	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	108-112
22004718-2	2011	Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC(50)=1 nM) with 740-fold selectivity over PKA (47).	7-azaindole dimer	90-101	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	150-154
22004718-4	2011	Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.	Lysine	210-213	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	50-57
22004718-4	2011	Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.	Lysine	210-213	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	221-228
21917869-7	2011	The expression of alpha-smooth muscle actin, RhoA, ROCK-I, and ROCK-II proteins was inhibited by fasudil administration.	fasudil	97-104	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	63-70
21770894-7	2011	These results, together with our previously observed miR-138 effects on cell migration and invasion through targeting RhoC (Rho-related GTP-binding protein C) and ROCK2 (Rho-associated, coiled-coil-containing protein kinase 2) concurrently, suggest that miR-138 is a multi-functional molecular regulator and plays major roles in EMT and in HNSCC progression.	mir-138	53-60	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	163-168
21770894-7	2011	These results, together with our previously observed miR-138 effects on cell migration and invasion through targeting RhoC (Rho-related GTP-binding protein C) and ROCK2 (Rho-associated, coiled-coil-containing protein kinase 2) concurrently, suggest that miR-138 is a multi-functional molecular regulator and plays major roles in EMT and in HNSCC progression.	mir-138	53-60	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	170-225
21770894-7	2011	These results, together with our previously observed miR-138 effects on cell migration and invasion through targeting RhoC (Rho-related GTP-binding protein C) and ROCK2 (Rho-associated, coiled-coil-containing protein kinase 2) concurrently, suggest that miR-138 is a multi-functional molecular regulator and plays major roles in EMT and in HNSCC progression.	mir-138	254-261	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	170-225
22230399-6	2011	The PKG inhibitor Rp-8-CPT-cGMPS (10 microM) blunted the inhibition of ROCK-II by KMUP-1.	Cyclic GMP	27-32	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	71-78
20401628-1	2010	The role of sphingosine 1-phosphate (S1P)-induced Rho kinase (ROCK) activation in the angiogenic responses of pulmonary artery-derived endothelial cells (PAEC) and smooth muscle cells (PASMC) was examined.	sphingosine 1-phosphate	12-35	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	62-66
20661774-0	2010	Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.	Ouabain	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	90-96
20661774-11	2010	Ouabain treatment induced cleavage of Rock-1 and Rock-2, which was prevented by caspase-3 and caspase-2 specific inhibitors z-DEVD-fmk and z-VDVAD-fmk, respectively.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	124-134	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-55
20661774-11	2010	Ouabain treatment induced cleavage of Rock-1 and Rock-2, which was prevented by caspase-3 and caspase-2 specific inhibitors z-DEVD-fmk and z-VDVAD-fmk, respectively.	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone	139-150	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-55
20401628-1	2010	The role of sphingosine 1-phosphate (S1P)-induced Rho kinase (ROCK) activation in the angiogenic responses of pulmonary artery-derived endothelial cells (PAEC) and smooth muscle cells (PASMC) was examined.	sphingosine 1-phosphate	37-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	62-66
20401628-4	2010	Similarly, PASMCs transfected with ROCK II siRNA diminished S1P-induced inhibition of the development of multi-cellular structures.	pasmcs	11-17	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	35-42
20429915-7	2010	The extracellular small GTPase RhoA/ROCK-2 cascade mediated the increased moesin expression and phosphorylation, which was discovered by the use of Y-27632, a specific inhibitor of Rho kinase and by transfected constitutively active, dominant-negative RhoA as well as ROCK-2 SiRNA.	Y 27632	148-155	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-42
20232393-3	2010	Here, we demonstrate that miR-138 suppresses TSCC cell migration and invasion by regulating 2 key genes in the Rho GTPase signaling pathway: RhoC and ROCK2.	mir-138	26-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	150-155
20232393-4	2010	Direct targeting of miR-138 to specific sequences located in the 3"-untranslated regions of both RhoC and ROCK2 mRNAs was confirmed using luciferase reporter gene assays.	mir-138	20-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	106-111
20232393-5	2010	Ectopic transfection of miR-138 reduced the expression of both RhoC and ROCK2 in TSCC cells.	mir-138	24-31	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	72-77
20232393-8	2010	Taken together, our results suggest that miR-138 plays an important role in TSCC cell migration and invasion by concurrently targeting RhoC and ROCK2, and miR-138 may serve as a novel therapeutic target for TSCC patients at risk of metastatic disease.	mir-138	41-48	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	144-149
19338998-12	2010	The expression of alpha-smooth muscle actin, Ras homology (Rho) A, Rho-associated coiled-coil-forming protein kinase (ROCK)-I, and ROCK-II was down-regulated by heparin administration.	Heparin	161-168	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	131-138
20181930-7	2010	Particularly, ROCK2 was found to dynamically associate with LOX-1 in the presence of OxLDL.	oxldl	85-90	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	14-19
20181930-8	2010	In addition, OxLDL treatment stimulated ROCK2 catalytic activity, and ROCK2 inhibition attenuated NF-kappaB activation and IL-8 production resulting from OxLDL activation of LOX-1.	oxldl	13-18	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	40-45
20181930-8	2010	In addition, OxLDL treatment stimulated ROCK2 catalytic activity, and ROCK2 inhibition attenuated NF-kappaB activation and IL-8 production resulting from OxLDL activation of LOX-1.	oxldl	154-159	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
20429915-7	2010	The extracellular small GTPase RhoA/ROCK-2 cascade mediated the increased moesin expression and phosphorylation, which was discovered by the use of Y-27632, a specific inhibitor of Rho kinase and by transfected constitutively active, dominant-negative RhoA as well as ROCK-2 SiRNA.	Y 27632	148-155	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	268-274
19634142-7	2009	In contrast, ROCK2 distribution in microdomains was decreased by treatment of cells with C8-L-threo-lactosylceramide, a glycosphingolipid with non-natural stereochemistry.	c8-l-threo-lactosylceramide	89-116	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	13-18
20347825-10	2010	Once activated, RhoA-GTP will activate downstream effectors, including ROCK1 and ROCK2.	Guanosine Triphosphate	21-24	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	81-86
19740074-5	2009	We also observed that several ROCK (Rho kinase) inhibitors such as Y-27632 and H-1152, suppressed LRRK2 with similar potency to which they inhibited ROCK2.	Y 27632	67-74	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	30-34
19740074-5	2009	We also observed that several ROCK (Rho kinase) inhibitors such as Y-27632 and H-1152, suppressed LRRK2 with similar potency to which they inhibited ROCK2.	Y 27632	67-74	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	149-154
19740074-5	2009	We also observed that several ROCK (Rho kinase) inhibitors such as Y-27632 and H-1152, suppressed LRRK2 with similar potency to which they inhibited ROCK2.	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	79-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	30-34
19740074-5	2009	We also observed that several ROCK (Rho kinase) inhibitors such as Y-27632 and H-1152, suppressed LRRK2 with similar potency to which they inhibited ROCK2.	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	79-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	149-154
20164172-8	2010	Small interfering RNA-facilitated knockdown of each isoform identified ROCK2 as the mediator of LPA-driven phosphorylation of NF-kappaB p65 and of ICAM-1 and VCAM-1 mRNA and protein induction.	lysophosphatidic acid	96-99	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	71-76
19837589-0	2009	Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.	Benzothiazoles	0-14	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-48
19837589-1	2009	A series of benzothiazole derivatives as ROCK inhibitors have been discovered.	benzothiazole	12-25	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-45
19634142-7	2009	In contrast, ROCK2 distribution in microdomains was decreased by treatment of cells with C8-L-threo-lactosylceramide, a glycosphingolipid with non-natural stereochemistry.	Glycosphingolipids	120-137	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	13-18
19239907-11	2009	The expression of ROCK1 and ROCK2 in membrane fractions of muscle was increased by acetylcholine; more specifically, ROCK2 continually expressed up to 5 min.	Acetylcholine	83-96	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	28-33
19506078-10	2009	These data suggest that n-6 dietary fatty acids stimulate a set of interactions that regulates cell adhesion through RhoA and ROCK II via a p38 MAPK-dependent association of HSP27 and p115RhoGEF.	n-6 dietary fatty acids	24-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	126-133
19391117-2	2009	We generated mice expressing 4-hydroxytamoxifen (4HT)-regulated human ROCK II (ROCKII:mER) under the transcriptional control of the cytokeratin14 (K14) promoter.	hydroxytamoxifen	29-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-77
19391117-2	2009	We generated mice expressing 4-hydroxytamoxifen (4HT)-regulated human ROCK II (ROCKII:mER) under the transcriptional control of the cytokeratin14 (K14) promoter.	4'-hydroxytamoxifen	49-52	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-77
19506078-5	2009	Inhibition of the Rho kinase (ROCK) with either small molecule inhibitors or ROCK II-specific small interfering RNA (siRNA) blocked the fatty acid-induced adhesion.	Fatty Acids	136-146	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	77-84
19099536-3	2009	ROCK2 harbours a C-terminal extension within the kinase domain that contains a hydrophobic cluster of phenylalanine and tyrosine residues surrounding a key threonine residue.	Phenylalanine	102-115	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
19099536-3	2009	ROCK2 harbours a C-terminal extension within the kinase domain that contains a hydrophobic cluster of phenylalanine and tyrosine residues surrounding a key threonine residue.	Tyrosine	120-128	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
19099536-3	2009	ROCK2 harbours a C-terminal extension within the kinase domain that contains a hydrophobic cluster of phenylalanine and tyrosine residues surrounding a key threonine residue.	Threonine	156-165	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
19099536-9	2009	Mechanistically, both ROCK2 activity and dimerization were dependent upon the interaction between Thr(405) of the hydrophobic motif and Asp(39) of the N-terminal extension.	Threonine	98-101	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
19099536-9	2009	Mechanistically, both ROCK2 activity and dimerization were dependent upon the interaction between Thr(405) of the hydrophobic motif and Asp(39) of the N-terminal extension.	Aspartic Acid	136-139	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
19239907-11	2009	The expression of ROCK1 and ROCK2 in membrane fractions of muscle was increased by acetylcholine; more specifically, ROCK2 continually expressed up to 5 min.	Acetylcholine	83-96	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	117-122
18665217-6	2008	The extra-cellular small GTPase RhoA/Rho-associated kinase (ROCK-2) cascade plays central role in progesterone- and MPA-induced moesin activation, cell migration and invasion.	Progesterone	98-110	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	60-66
18834107-0	2008	Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.	4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides	25-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	119-126
18832915-4	2008	This study was designed to compare gene expression profiles of atorvastatin with the newly developed ROCK2 inhibitor SLx-2119 in primary cultures of normal human endothelial cells, smooth muscle cells, and fibroblasts.	KD025	117-125	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	101-106
17639498-1	2007	BACKGROUND: Soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) and Rho kinase (ROCK2) pathways are important in the regulation of prostate smooth muscle tone.	Cyclic GMP	43-73	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	120-125
18493596-6	2008	Moesin activation by estradiol depends on the interaction of ER alpha with the G protein G alpha(13), which results in the recruitment of the small GTPase RhoA and in the subsequent activation of its downstream effector Rho-associated kinase-2 (ROCK-2).	Estradiol	21-30	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	220-243
18493596-6	2008	Moesin activation by estradiol depends on the interaction of ER alpha with the G protein G alpha(13), which results in the recruitment of the small GTPase RhoA and in the subsequent activation of its downstream effector Rho-associated kinase-2 (ROCK-2).	Estradiol	21-30	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	245-251
18303050-9	2008	These studies support a model in which FAK and PDZ-RhoGEF cooperate to induce Rho/ROCKII-dependent focal adhesion movement and trailing-edge retraction in response to LPA.	lysophosphatidic acid	167-170	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	82-88
17639498-7	2007	Moreover, KMUP-1 inhibited phenylephrine-induced ROCK2 expression.	Phenylephrine	27-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
17666911-1	2007	The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho.	Guanosine Triphosphate	110-113	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	42-47
17368019-3	2007	SR-1459 has IC(50)=13nM versus ROCK-II while the IC(50)s for SR-715 and SR-899 are 80nM and 100nM, respectively.	Strontium	0-2	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-38
17368019-5	2007	However, a few of these inhibitors (SR-715 and SR-899) show strong selectivity for ROCK-II over CYP3A4, but the overall potency of the 2-amino analogs (SR-1459) on CYP3A4 and the high clearance and volume of distribution of these compounds makes the in vivo utility of these analogs undesirable.	CHEMBL241271	36-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	83-90
17368019-0	2007	Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.	indazole piperazine	89-108	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	147-154
17368019-0	2007	Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.	indazole piperidine	113-132	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	147-154
17368019-5	2007	However, a few of these inhibitors (SR-715 and SR-899) show strong selectivity for ROCK-II over CYP3A4, but the overall potency of the 2-amino analogs (SR-1459) on CYP3A4 and the high clearance and volume of distribution of these compounds makes the in vivo utility of these analogs undesirable.	Strontium	36-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	83-90
17240358-5	2007	Taken together, our results demonstrate that the expression and activity of ROCK1 and ROCK2 can be uncoupled in a signal-dependent manner, and further implicate a new function for ROCK2 in the steroid control of tight junction dynamics.	Steroids	193-200	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	86-91
17240358-5	2007	Taken together, our results demonstrate that the expression and activity of ROCK1 and ROCK2 can be uncoupled in a signal-dependent manner, and further implicate a new function for ROCK2 in the steroid control of tight junction dynamics.	Steroids	193-200	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	180-185
17015463-8	2006	We further found that ROCK II kinase activity is significantly enhanced by binding to NPM/B23 and that NPM/B23 acquires a higher binding affinity to ROCK II upon phosphorylation on Thr(199).	Threonine	181-184	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-29
17516712-1	2007	Rho kinase (ROCK1 and ROCK2) is a serine/threonine kinase that serves as an important downstream effector of Rho GTPase, and plays a critical role in regulating the contractile tone of smooth muscle tissues in a calcium-independent manner.	Calcium	212-219	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
17015463-8	2006	We further found that ROCK II kinase activity is significantly enhanced by binding to NPM/B23 and that NPM/B23 acquires a higher binding affinity to ROCK II upon phosphorylation on Thr(199).	Threonine	181-184	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	149-156
17015463-9	2006	Moreover, physical interaction between ROCK II and NPM/B23 in vivo occurs in association with CDK2/cyclin E activation and the emergence of Thr(199)-phosphorylated NPM/B23.	Threonine	140-143	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	39-46
14664814-7	2003	In retinal ganglion cells, either olomoucine at 20 microM or Y-27632 at 10 microM, an inhibitor of Rho-kinase/ROKalpha/ROCKII, showed maximum inhibitory effect against ephrin-A5 (10 microg/ml)-induced growth cone collapse.	olomoucine	34-44	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	119-125
16043513-9	2005	ROCK II bound phosphatidylinositol 3,4,5P(3) and was sensitive to its levels, properties not shared by ROCK I.	Phosphatidylinositols	14-34	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
16043513-9	2005	ROCK II bound phosphatidylinositol 3,4,5P(3) and was sensitive to its levels, properties not shared by ROCK I.	,4,5p	36-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
16720831-9	2006	Exposure of HMEC-1 to thrombin in presence of the caspase-2 selective inhibitor Z-VDVAD-FMK prevented ROCK-II cleavage and inhibited the thrombin-induced EMP release.	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone	80-91	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	102-109
16934677-5	2006	Increased ET-1 production induced by 8-isoprostane was significantly attenuated by the ROCK inhibitors Y-27632 and hydroxyfasudil, but not by inhibitors of the other pathways.	8-epi-prostaglandin F2alpha	37-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-91
16934677-5	2006	Increased ET-1 production induced by 8-isoprostane was significantly attenuated by the ROCK inhibitors Y-27632 and hydroxyfasudil, but not by inhibitors of the other pathways.	Y 27632	103-110	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-91
16934677-5	2006	Increased ET-1 production induced by 8-isoprostane was significantly attenuated by the ROCK inhibitors Y-27632 and hydroxyfasudil, but not by inhibitors of the other pathways.	hydroxyfasudil	115-129	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-91
16934677-6	2006	8-Isoprostane also increased membrane binding of RhoA, a major determinant of ROCK activity, and ROCK-II expression through the protein kinase C pathway.	8-epi-prostaglandin F2alpha	0-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	78-82
16934677-6	2006	8-Isoprostane also increased membrane binding of RhoA, a major determinant of ROCK activity, and ROCK-II expression through the protein kinase C pathway.	8-epi-prostaglandin F2alpha	0-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	97-104
16934677-7	2006	These data indicate that the RhoA/ROCK pathway mediates increased ET-1 production by PASMCs, which we speculate may at least partly explain the beneficial effects of both antioxidants and ROCK inhibitors in animal models of chronic pulmonary hypertension.	pasmcs	85-91	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	34-38
16934677-7	2006	These data indicate that the RhoA/ROCK pathway mediates increased ET-1 production by PASMCs, which we speculate may at least partly explain the beneficial effects of both antioxidants and ROCK inhibitors in animal models of chronic pulmonary hypertension.	pasmcs	85-91	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-192
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P<0.001), diastolic (P<0.0001), and mean BP (P<0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P<0.0001).	Asparagine	4-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P<0.001), diastolic (P<0.0001), and mean BP (P<0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P<0.0001).	Asparagine	8-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
16585408-5	2006	The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P<0.001), diastolic (P<0.0001), and mean BP (P<0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P<0.0001).	Asparagine	8-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	188-193
14664814-7	2003	In retinal ganglion cells, either olomoucine at 20 microM or Y-27632 at 10 microM, an inhibitor of Rho-kinase/ROKalpha/ROCKII, showed maximum inhibitory effect against ephrin-A5 (10 microg/ml)-induced growth cone collapse.	Y 27632	61-68	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	119-125
12176052-6	2002	Expression of ROCK-II (1-543) as an N-terminal Flag fusion protein allowed a single-step purification yielding greater than 90% homogeneous protein as assessed by SDS-PAGE.	Sodium Dodecyl Sulfate	163-166	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	14-21
12126956-2	2002	ROCK II can induce membrane blebbing in the presence of the caspase inhibitor z-VAD-fmk or in caspase-3-deficient MCF-7 cells, indicating that the activation of caspases is not required.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	78-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
12126956-3	2002	ROCK-II-induced membrane blebbing, however, is reversed by the myosin light chain kinase inhibitor ML-7 or cytochalasin D.	ML 7	99-103	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
12126956-3	2002	ROCK-II-induced membrane blebbing, however, is reversed by the myosin light chain kinase inhibitor ML-7 or cytochalasin D.	Cytochalasin D	107-121	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-7
34581498-0	2021	Design, Synthesis and Biological Evaluation of Urea-based ROCK2 inhibitors.	Urea	47-51	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	58-63
11350930-0	2001	Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2.	Tretinoin	31-44	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	67-91
33779714-9	2021	In addition, RhoA, ROCK2 and phosphorylated myosin phosphatase target subunit-1 (p-MYPT-1) expressions were down-regulated by fasudil.	fasudil	126-133	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	19-24
33760847-5	2021	The screen identified dimethylfasudil, a potent and reversible inhibitor of Rho-associated kinases, ROCK1 and ROCK2.	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	22-37	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-115
34581498-1	2021	A series of urea-based ROCK2 inhibitors were design and synthesized.	Urea	12-16	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	23-28
34581498-3	2021	The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity.	Urea	34-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	69-74
34600176-10	2021	RESULTS: DS inhibited HCC cell proliferation, induced HCC cell apoptosis and repressed VM formation by inactivating RhoA/ROCK2-mediated AKT and ERK-p38 MAPK signaling.	daurisoline	9-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-126
34770791-0	2021	Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners.	Dexamethasone	37-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	4-8
34770791-0	2021	Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners.	Dexamethasone	37-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	13-18
34917911-0	2022	ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis.	Thioacetamide	74-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
34627383-18	2021	Targeting the RhoA/ROCK2/LIMK2/YAP pathway can significantly improve the efficacy of MPPa-PDT treatment for OS.	15-phenyl-beta-methylpentadecanoic acid	85-89	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	19-24
34917911-3	2022	Methods: We used the thioacetamide-induced liver fibrosis model to examine the efficacy of administration of the selective ROCK2 inhibitor KD025 to prevent or treat liver fibrosis and its impact on immune composition and function.	KD025	139-144	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	123-128
34400321-5	2021	Furthermore, the selective inhibition of ROCK2 by belumosudil reduces fibrosis by downregulating both transforming growth factor-beta signaling and profibrotic gene expression, thereby impeding the creation of focal adhesions.	KD025	50-61	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-46
34639115-8	2021	LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression.	lysophosphatidic acid	174-177	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	47-52
34639115-8	2021	LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression.	lysophosphatidic acid	174-177	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-139
34146643-7	2021	The mRNA and protein levels of ROCK1, ROCK2, MLC, and LIMK were significantly reduced and cofilin mRNA and protein levels were significantly increased in GES-1 cells treated with the RhoA inhibitor CCG-1423.	CCG 1423	198-206	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	38-43
35339032-0	2022	Belumosudil with ROCK-2 inhibition: chemical and therapeutic development to FDA approval for the treatment of chronic graft-versus-host disease.	KD025	0-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	17-23
34270712-2	2021	SUMMARY ANSWER: Rho-dependent protein kinase (ROCK) activity is elevated in response to the combined treatment with progesterone and 8-Br-cAMP during in vitro decidualization, mirrored by increase of ROCK2 mRNA and protein levels and the phosphorylation levels of its downstream target Cofilin-1 (CFL1) in secretory versus proliferative endometrium.	8-Bromo Cyclic Adenosine Monophosphate	133-142	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	200-205
34483923-0	2021	Methyl Ferulic Acid Attenuates Human Cardiac Fibroblasts Differentiation and Myocardial Fibrosis by Suppressing pRB-E2F1/CCNE2 and RhoA/ROCK2 Pathway.	methyl ferulic acid	0-19	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	136-141
34270712-2	2021	SUMMARY ANSWER: Rho-dependent protein kinase (ROCK) activity is elevated in response to the combined treatment with progesterone and 8-Br-cAMP during in vitro decidualization, mirrored by increase of ROCK2 mRNA and protein levels and the phosphorylation levels of its downstream target Cofilin-1 (CFL1) in secretory versus proliferative endometrium.	Progesterone	116-128	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	200-205
34903975-4	2021	The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives displayed certain ROCK II inhibitory activities.	4-aryl-5-aminomethyl-thiazole-2-amines	24-62	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	93-100
34349088-11	2021	Crocetin treatment significantly increased survival, attenuated myocardial necrotic lesions, reduced CVB3 replication and expression of ROCK2 and IL-17 in the infected hearts.	crocetin	0-8	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	136-141
35257471-3	2022	In osteoclastic precursor cells, 10 nM Cd induced pseudopodia stretching, promoted cell migration, upregulated the levels of Cdc42, and RhoQ mRNAs and downstream Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 proteins, and downregulated the actin-related protein 2/3 (ARP2/3) levels.	Cadmium	39-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	210-215
35339032-1	2022	Belumosudil (BLM) is a ROCK inhibitor that has been firstly developed by Surface Logix, later acquired by Kadmon Pharmaceuticals for the treatment of chronic graft-versus-host disease (cGVHD), Psoriasis Vulgaris (PV), idiopathic pulmonary fibrosis (IPF), hepatic impairment (HI), diffuse cutaneous systemic sclerosis (dcSSc).	KD025	0-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	23-27
35257471-5	2022	In osteoclasts, 10 nM Cd induced the formation of sealing zones, slightly upregulated Cdc42 mRNA levels and ROCK2 and ARP2/3 protein levels and significantly reduced p-cofilin levels.	Cadmium	22-24	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	108-113
35451708-9	2022	Collectively, our data imply that Midazolam ameliorated the impairment of the BBB against LPS by regulating the RhoA/ROCK2 pathway.	Midazolam	34-43	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	117-122
35523828-3	2022	A gene expression analysis using ROCK-is indicated that KD025 (ROCK2 selective ROCK inhibitor) induced more significant changes than Rip (ripasudil, pan-ROCK inhibitor), suggesting that ROCK2 might be more extensively involved in the metabolism of ECM proteins and cell architectures of the 2D cultured HCSFs than ROCK1.	K-115	138-147	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	186-191
35132805-14	2022	In vitro studies showed that RhoA/ROCK2 pathway was significantly activated by PDGF-AA (n = 3, 1.88-fold increase, P < 0.01) and both C3-exoenzyme and fasudil blocked that activation (n = 3, P < 0.05 and P < 0.001, respectively).	fasudil	151-158	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	34-39
35535812-6	2022	Belumosudil mesylate is a selective oral ROCK2 inhibitor that has demonstrated safety and efficacy for cGvHD.	Belumosudil mesylate	0-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-46
35443042-7	2022	There are currently 3 FDA approvals for the treatment of chronic GVHD: (1) ibrutinib, a BTK inhibitor traditionally used for B-cell malignancies, was the first agent approved for chronic GVHD after failure of one or more lines of systemic therapy, (2) belumosudil, an oral selective inhibitor of ROCK2, for patients with chronic GVHD who received at least 2 prior lines of treatment, and (3) ruxolitinib for chronic GVHD after failure of one or two lines of systemic therapy.	ibrutinib	75-84	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	296-301
35560286-9	2022	Specifically, GFNs with higher surface oxidation elicit stronger ROCK2 inhibitory behavior as compared to pristine graphene sheets.	gfns	14-18	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	65-70
35560286-9	2022	Specifically, GFNs with higher surface oxidation elicit stronger ROCK2 inhibitory behavior as compared to pristine graphene sheets.	Graphite	115-123	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	65-70
35378380-5	2022	miR-142-3p also inhibits the expression of RAC1, ROCK2 and CLIC4, three genes that are critical for EC migration and angiogenic responses.	mir-142-3p	0-10	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
35322742-0	2022	Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2.	terpinenol-4	0-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	99-153
35322742-6	2022	Rho-associated coiled-coil containing protein kinase 2 (ROCK2), a DEG enriched in the RHO/RHOA signaling pathway, was considered as a key target of T4O in PC cells; it was significantly reduced after T4O treatment, highly expressed in PC tissues, and negatively associated with patient outcome.	terpinenol-4	148-151	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-54
35322742-6	2022	Rho-associated coiled-coil containing protein kinase 2 (ROCK2), a DEG enriched in the RHO/RHOA signaling pathway, was considered as a key target of T4O in PC cells; it was significantly reduced after T4O treatment, highly expressed in PC tissues, and negatively associated with patient outcome.	terpinenol-4	148-151	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	56-61
35322742-7	2022	Overexpression of ROCK2 significantly reduced the inhibitory effects of T4O on PC cell proliferation and mobility.	terpinenol-4	72-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
35322742-9	2022	In conclusion, we consider that T4O can suppress the malignant biological behavior of PC by reducing the expression of ROCK2, thus contributing to PC therapy.	terpinenol-4	32-35	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	119-124
35406401-10	2022	CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR-139-5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway.	Azacitidine	51-56	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	142-147
35406401-0	2022	5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway.	Azacitidine	0-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	139-144
35145081-0	2022	Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2.	Temozolomide	9-21	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	120-125
35406401-6	2022	RESULTS: 5-Aza downregulated cell viability/growth/migration/adhesion by upregulating miR-139-5p, which in turn downregulated ROCK2/cyclin D1/E2F1 and increased p27kip1, resulting in G1/G0 cell accumulation.	Azacitidine	9-14	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	126-131
35406401-10	2022	CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR-139-5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway.	Azacitidine	51-56	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	207-212
35238174-1	2022	Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 inhibitor.	KD025	0-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	27-81
35231159-1	2022	Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor.	KD025	0-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	27-81
35231159-1	2022	Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor.	KD025	0-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	83-88
35172179-11	2022	Fasudil caused a decrease of ROCK2 protein content (P = .014).	fasudil	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-34
35172179-12	2022	CONCLUSIONS: Fasudil fully relaxes various vasoconstrictors-induced contraction and decreases ROCK2 protein in ITA.	fasudil	13-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	94-99
35145081-2	2022	In this study, we demonstrated that rho-associated kinase 2 (ROCK2), a cytoskeleton regulator, was highly expressed in MGMTlow recurrent gliomas, and its expression strongly correlated with poor overall survival (OS) time in a subset of MGMTlow recurrent gliomas patients with TMZ therapy.	Temozolomide	277-280	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-59
35145081-2	2022	In this study, we demonstrated that rho-associated kinase 2 (ROCK2), a cytoskeleton regulator, was highly expressed in MGMTlow recurrent gliomas, and its expression strongly correlated with poor overall survival (OS) time in a subset of MGMTlow recurrent gliomas patients with TMZ therapy.	Temozolomide	277-280	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	61-66
35145081-3	2022	And we also found that overactive ROCK2 enhanced homologous recombination repair (HR) in TMZ-resistant (TMZ-R) glioma cell lines with low MGMT expression.	Temozolomide	89-92	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	34-39
35145081-3	2022	And we also found that overactive ROCK2 enhanced homologous recombination repair (HR) in TMZ-resistant (TMZ-R) glioma cell lines with low MGMT expression.	Temozolomide	104-107	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	34-39
35145081-4	2022	Silencing ROCK2 impaired HR repair, and induced double-strand break (DSB) and eradicated TMZ-R glioma cells in culture.	Temozolomide	89-92	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	10-15
35145081-8	2022	These results provide evidence for the use of ROCK inhibitors in the clinical therapy for MGMTlow TMZ-resistant glioma.	Temozolomide	98-101	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	46-50
35126623-7	2022	Overexpression of miR-31-3p could distinctly improve the proliferation, invasion, and migration of A549 cells, meanwhile inhibit cell apoptosis, and activate the RhoA/ROCK-2 signaling pathway, while interfering with the expression of miR-31-3p has the opposite function.	mir-31-3p	18-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-173
33660517-8	2021	Hypoxia-induced ROCK2/Rab10 signaling was prevented by statin and recovered by exogenous GGPP.	geranylgeranyl pyrophosphate	89-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	16-21
34044123-3	2021	Structure-activity relationship studies led to the discovery of compound 12b, which showed potent activities against ROCK I and ROCK II with IC50 values of 93 nM and 3 nM, respectively.	12b	73-76	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	128-135
34874326-4	2022	Our previous study indicated that PEG-PEI/siROCK2 (polyethyleneglycol-polyethyleneimine deliver ROCK2-siRNA, (PPSR)) prevented Abeta42-induced neurotoxicity and showed a promising prospect for the treatment of Alzheimer"s disease.	poly(ethylene glycol)-co-poly(ethyleneimine)	34-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	96-101
34874326-4	2022	Our previous study indicated that PEG-PEI/siROCK2 (polyethyleneglycol-polyethyleneimine deliver ROCK2-siRNA, (PPSR)) prevented Abeta42-induced neurotoxicity and showed a promising prospect for the treatment of Alzheimer"s disease.	sirock2	42-49	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	96-101
34874326-4	2022	Our previous study indicated that PEG-PEI/siROCK2 (polyethyleneglycol-polyethyleneimine deliver ROCK2-siRNA, (PPSR)) prevented Abeta42-induced neurotoxicity and showed a promising prospect for the treatment of Alzheimer"s disease.	polyethyleneglycol-polyethyleneimine	51-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	96-101
33617967-15	2021	CONCLUSIONS: The present study suggested that XST exerted long-term neuroprotective effects that assisted in stroke recovery, possibly through inhibition of the ROCKII pathway.	xuesetong	46-49	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	161-167
33877856-0	2021	ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease.	KD025	22-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
33995991-9	2021	Overexpression of NEAT1 or ROCK2 promoted immune cell (CD4+T cells) proliferation, Th17 cell differentiation, and cell migration in response to stimulus, whereas knockout of the NEAT1 gene induced the expression of miR-144-3p in CD4+T cells.	mir-144-3p	215-225	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	27-32
33995991-10	2021	ROCK2 exogenous expression inhibited the expression of miR-144-3p, inducing activation of the WNT signaling pathway.	mir-144-3p	55-65	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
33877856-2	2021	Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel approach to the management of chronic graft-versus-host disease (cGVHD).	KD025	32-43	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	10-15
33877856-2	2021	Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel approach to the management of chronic graft-versus-host disease (cGVHD).	KD025	45-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	10-15
33790742-1	2021	Rho-associated coiled-coil containing kinase isoform 2 (ROCK2) is a member of the AGC family of serine/threonine kinases and an extensively studied regulator of actin-mediated cytoskeleton contractility.	Serine	96-102	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-54
33576448-12	2021	Moreover, miR-20a-5p directly bound to ROCK2, and miR-20a-5p inhibition aggravated ox-LDL-induced injury by increasing the ROCK2 level.	mir-20a-5p	10-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	39-44
33576448-12	2021	Moreover, miR-20a-5p directly bound to ROCK2, and miR-20a-5p inhibition aggravated ox-LDL-induced injury by increasing the ROCK2 level.	mir-20a-5p	10-20	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	123-128
33576448-12	2021	Moreover, miR-20a-5p directly bound to ROCK2, and miR-20a-5p inhibition aggravated ox-LDL-induced injury by increasing the ROCK2 level.	mir-20a-5p	50-60	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	123-128
33388549-4	2021	Here, we identified that Wnt3A promoted superoxide generation, leading to Tyr42 phosphorylation of RhoA through activations of c-Src and Rho-dependent coiled coil kinase 2 (ROCK2) and phosphorylation of p47phox, a component of NADPH oxidase.	Superoxides	40-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	137-171
33388549-4	2021	Here, we identified that Wnt3A promoted superoxide generation, leading to Tyr42 phosphorylation of RhoA through activations of c-Src and Rho-dependent coiled coil kinase 2 (ROCK2) and phosphorylation of p47phox, a component of NADPH oxidase.	Superoxides	40-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	173-178
33790742-1	2021	Rho-associated coiled-coil containing kinase isoform 2 (ROCK2) is a member of the AGC family of serine/threonine kinases and an extensively studied regulator of actin-mediated cytoskeleton contractility.	Serine	96-102	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	56-61
33732368-9	2021	Moreover, salidroside, isorhamnetin and both in combination attenuated the mRNA and protein expression levels of RhoA and ROCK II in vivo and in vitro, at concentrations corresponding to human therapeutic blood plasma concentrations.	rhodioloside	10-21	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-129
33732368-9	2021	Moreover, salidroside, isorhamnetin and both in combination attenuated the mRNA and protein expression levels of RhoA and ROCK II in vivo and in vitro, at concentrations corresponding to human therapeutic blood plasma concentrations.	3-methylquercetin	23-35	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-129
33732368-12	2021	Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.	rhodioloside	41-52	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-117
33732368-12	2021	Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.	3-methylquercetin	54-66	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-117
33732368-12	2021	Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.	urotensin II	181-184	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-117
33515560-14	2021	Moreover, RhoA was a target of miR-140-5p and miR-140-5p inhibited the activation of RhoA/ROCK2 signaling.	mir-140-5p	31-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	90-95
33613315-10	2021	The inhibition of ROCK by Y-27632 attenuated the sensitivity to U46619 in both control and PAH-MCT.	Y 27632	26-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-22
33613315-10	2021	The inhibition of ROCK by Y-27632 attenuated the sensitivity to U46619 in both control and PAH-MCT.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	64-70	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-22
33613315-10	2021	The inhibition of ROCK by Y-27632 attenuated the sensitivity to U46619 in both control and PAH-MCT.	mct	95-98	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-22
33160621-5	2021	The in vitro and in vivo effects of the ROCK2-specific inhibitor, KD025, were examined herein using pulmonary arterial smooth muscle cells (PASMCs) from idiopathic pulmonary arterial hypertension (IPAH) patients and monocrotaline (MCT)-induced pulmonary hypertensive (PH) rats.	KD025	66-71	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	40-45
33817282-0	2020	MiR-30c-5p/ROCK2 axis regulates cell proliferation, apoptosis and EMT via the PI3K/AKT signaling pathway in HG-induced HK-2 cells.	mir-30c	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	11-16
33817282-4	2020	Compared with the controls, DN tissues and high glucose-induced HK-2 cells had significantly reduced miR-30c-5p levels, while ROCK2 expression was prominently elevated.	Glucose	48-55	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	126-131
32805407-1	2020	A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno[4,3-d]pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described.	SCHEMBL6615574	18-44	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	142-147
33294632-9	2020	ROCK2 expression levels were specifically downregulated by Y-27632 in the Rho/ROCK signaling pathway.	Y 27632	59-66	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
33153478-0	2020	circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2.	Cisplatin	63-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-139
33153478-6	2020	Furthermore, the regulation of cisplatin sensitivity and autophagy by circCUL2/miR-142-3p/ROCK2 was demonstrated by cellular apoptosis assays, western blot, immunofluorescence and transmission electron microscopy analyses.	Cisplatin	31-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	90-95
33153478-10	2020	Furthermore, in the AGS/DDP and SGC-7901/DDP cell lines, circCUL2 regulated cisplatin sensitivity through miR-142-3p/ROCK2-mediated autophagy activation.	Cisplatin	76-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	117-122
33153478-11	2020	CONCLUSION: circCUL2 may function as a tumor suppressor and regulator of cisplatin sensitivity through miR-142-3p/ROCK2-mediated autophagy activation, which could be a key mechanism and therapeutic target for GC.	Cisplatin	73-82	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	114-119
32805407-1	2020	A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno[4,3-d]pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described.	SCHEMBL11558683	46-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	142-147
32805407-1	2020	A novel series of 5H-chromeno[3,4-c]pyridine, 6H-isochromeno[3,4-c]pyridine and 6H-isochromeno[4,3-d]pyrimidine derivatives as dual ROCK1 and ROCK2 inhibitors is described.	SCHEMBL17453005	80-111	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	142-147
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	302-309	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	144-149
32912437-0	2020	Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors.	4-aryl-5-aminoalkyl-thiazole-2-amines	47-84	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	100-107
32912437-1	2020	A series of 4-aryl-5-aminoalkyl-thiazole-2-amines were designed and synthesized, and their inhibitory activity on ROCK II was screened by enzyme-linked immunosorbent assay (ELISA).	4-aryl-5-aminoalkyl-thiazole-2-amines	12-49	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	114-121
32912437-2	2020	The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives had certain ROCK II inhibitory activities.	4-aryl-5-aminomethyl-thiazole-2-amines	24-62	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-94
32942936-0	2020	Downregulation of ROCK2 attenuates alcohol-induced inflammation and oxidative stress in astrocytes.	Alcohols	35-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-6	2020	Proteins involved in nuclear factor kappa B (NF-kappaB) signaling pathway and NOD-like receptor protein 3 (NLRP3) inflammasome were analyzed by Western blotting.Results: Alcohol exposure dramatically upregulated ROCK2 expression and lactate dehydrogenase (LDH) activity in astrocytes.	Alcohols	170-177	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	212-217
32942936-7	2020	On the contrary, transfecting with LV-anti-ROCK2 vector downregulated ROCK2 expression and LDH activity in astrocytes, demonstrating that downregulation of ROCK2 alleviated alcohol-induced astrocytic injury.	Alcohols	173-180	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	43-48
32942936-7	2020	On the contrary, transfecting with LV-anti-ROCK2 vector downregulated ROCK2 expression and LDH activity in astrocytes, demonstrating that downregulation of ROCK2 alleviated alcohol-induced astrocytic injury.	Alcohols	173-180	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
32942936-7	2020	On the contrary, transfecting with LV-anti-ROCK2 vector downregulated ROCK2 expression and LDH activity in astrocytes, demonstrating that downregulation of ROCK2 alleviated alcohol-induced astrocytic injury.	Alcohols	173-180	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
32942936-8	2020	Furthermore, downregulation of ROCK2 attenuated alcohol-induced inflammation by reducing the levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-6) and enhanced the level of anti-inflammatory IL-10.	Alcohols	48-55	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-36
32942936-9	2020	Downregulation of ROCK2 also attenuated alcohol-induced oxidative stress by reducing the reactive oxygen species (ROS) production, as well as enhancing the activity of anti-oxidative superoxide dismutase (SOD) and glutathione (GSH).	Alcohols	40-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-9	2020	Downregulation of ROCK2 also attenuated alcohol-induced oxidative stress by reducing the reactive oxygen species (ROS) production, as well as enhancing the activity of anti-oxidative superoxide dismutase (SOD) and glutathione (GSH).	Reactive Oxygen Species	89-112	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-9	2020	Downregulation of ROCK2 also attenuated alcohol-induced oxidative stress by reducing the reactive oxygen species (ROS) production, as well as enhancing the activity of anti-oxidative superoxide dismutase (SOD) and glutathione (GSH).	Reactive Oxygen Species	114-117	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-9	2020	Downregulation of ROCK2 also attenuated alcohol-induced oxidative stress by reducing the reactive oxygen species (ROS) production, as well as enhancing the activity of anti-oxidative superoxide dismutase (SOD) and glutathione (GSH).	Glutathione	214-225	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	302-309	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	144-149
32942936-9	2020	Downregulation of ROCK2 also attenuated alcohol-induced oxidative stress by reducing the reactive oxygen species (ROS) production, as well as enhancing the activity of anti-oxidative superoxide dismutase (SOD) and glutathione (GSH).	Glutathione	227-230	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	187-194	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-41
32705263-3	2020	The results confirmed that Rho-associated kinases (ROCKs), namely ROCK1 and ROCK2, were involved in the underlying pathway of ethanol-induced IEB dysfunction.	Ethanol	126-133	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	76-81
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	187-194	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	144-149
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	187-194	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	144-149
32942936-10	2020	More importantly, downregulation of ROCK2 inhibited the activation of NF-kappaB signaling pathway and NLRP3 inflammasome.Conclusion: Therefore, ROCK2 could be a potential target to treat alcohol-induced astrocytic injury and the downregulation of ROCK2 might be a promising approach to protect against alcohol-induced astrocytic injury.	Alcohols	302-309	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-41
33084595-4	2020	Furthermore, LPS induction significantly enhanced the expression of RhoA, ROCK1, and ROCK2 and the activation of ROCK; these effects were reduced by TSG pretreatment.	tsg	149-152	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	85-90
32705263-7	2020	Taken together, the results of the present study suggested that ROCK1/ROCK2-mediated activation of NF-kappaB and upregulation of AQP8 expression levels may represent a novel mechanism of ethanol-induced impairment of IEB function.	Ethanol	187-194	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
32770034-5	2020	This effect was also obtained using the other ROCK inhibitor Fasudil as well as with knocking down the expression of ROCK-1 or ROCK-2, but was prevented by the inhibition of NaV1.5 voltage-gated sodium channel activity.	Sodium	195-201	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	127-133
32753663-4	2020	ROCK2 is a serine-threonine kinase whose role in lymphomagenesis is unknown.	Serine	11-17	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
32647287-5	2020	Here we show that ROCK2 is a novel target of celastrol and inhibition of ROCK2 suppresses elicited ezrin activation and liver cancer cell migration.	celastrol	45-54	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
32647287-7	2020	The molecular target of celastrol was identified as ROCK2 using celastrol affinity pull-down assay.	celastrol	24-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	52-57
32647287-7	2020	The molecular target of celastrol was identified as ROCK2 using celastrol affinity pull-down assay.	celastrol	64-73	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	52-57
32647287-8	2020	Our molecular docking analyses indicated celastrol binds to the active site of ROCK2 kinase.	celastrol	41-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	79-84
32647287-9	2020	Mechanistically, celastrol inhibits the ROCK2-mediated phosphorylation of ezrin at Thr567 which harnesses liver cancer cell migration.	celastrol	17-26	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	40-45
32647287-10	2020	Our findings suggest that targeting ROCK2-ezrin signaling is a potential therapeutic niche for celastrol-based intervention of cancer progression in hepatocellular carcinoma.	celastrol	95-104	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-41
32229726-0	2020	Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.	Serine	0-6	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	24-29
32229726-7	2020	ATAC-Seq (assay for transposase-accessible chromatin with high-throughput sequencing) and biochemical analyses revealed that the effects of ROCK2 on cholesterol biosynthesis were instead mediated via a novel mechanism.	Cholesterol	149-160	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	140-145
32229726-0	2020	Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.	Cholesterol	79-90	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	24-29
32229726-8	2020	ROCK2 directly phosphorylated interferon regulatory factor 8 (IRF8), a crucial mediator of GC responses, and promoted its interaction with sterol regulatory element-binding transcription factor 2 (SREBP2) at key regulatory regions controlling the expression of cholesterol biosynthetic enzymes, resulting in optimal recruitment of SREBP2 at these sites.	Cholesterol	261-272	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
32229726-2	2020	RHO-associated coiled-coil-containing protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targeted by ROCK inhibitors or statins, is a key downstream effector of RHOA GTPases.	Serine	66-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-54
32229726-2	2020	RHO-associated coiled-coil-containing protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targeted by ROCK inhibitors or statins, is a key downstream effector of RHOA GTPases.	Serine	66-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	56-61
32229726-5	2020	RNA-Seq analyses revealed that ROCK2 controlled a unique transcriptional program in GC B cells that promoted optimal GC polarization and cholesterol biosynthesis.	Cholesterol	137-148	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-36
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	fasudil	41-48	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-174
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	1,4-diazepane	51-64	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-174
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	K-115	96-105	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-174
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	dimehtylfasudil	110-125	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-174
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	N-[2-(p-Cinnamylamino)ethyl]-5-isoquinolone Sulfonamide	275-284	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-174
32252692-3	2020	Ripasudil, which was used for the treatment of glaucoma, was one kind of the inhibitor of ROCK1 and ROCK2, but whether ripasudil could relieve the LPS-induced inflammation and damage of RPE cells was not clear.	K-115	0-9	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	100-105
32057928-0	2020	Identification of novel functions of the ROCK2-specific inhibitor KD025 by bioinformatics analysis.	KD025	66-71	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-46
32057928-2	2020	The ROCK2-specific inhibitor KD025 (SLx-2119) is currently undergoing phase II clinical trials, but its cellular functions have not been fully explored.	KD025	29-34	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	4-9
32057928-2	2020	The ROCK2-specific inhibitor KD025 (SLx-2119) is currently undergoing phase II clinical trials, but its cellular functions have not been fully explored.	KD025	36-44	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	4-9
32599797-10	2020	AN07 also attenuated MG-induced neurite damage via down-regulating the Rho-associated protein kinase 2 (ROCK2)/phosphorylated LIM kinase 1 (p-LIMK1) pathway.	Pyruvaldehyde	21-23	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	71-102
32599797-10	2020	AN07 also attenuated MG-induced neurite damage via down-regulating the Rho-associated protein kinase 2 (ROCK2)/phosphorylated LIM kinase 1 (p-LIMK1) pathway.	Pyruvaldehyde	21-23	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	104-109
32252692-5	2020	After that, we detected the levels of ROCK1 and ROCK2 by western-blotting after the stimulation of LPS and treatment of ripasudil.	K-115	120-129	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	48-53
32252692-6	2020	Then luciferase reporter assays were used to confirm the targeting effect of miR-136-5p on ROCK1 and ROCK2.	mir-136-5p	77-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	101-106
32252692-9	2020	After the treatment of ripasudil, the expression levels of ROCK1, ROCK2 and miR-136-5p were suppressed.	K-115	23-32	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	66-71
32252692-13	2020	CONCLUSION: Ripasudil relieved the inflammatory injury of RPE cells by upregulating miR-136-5p, therefore inhibiting the expression of ROCK1, ROCK2, NLRP3, ASC, caspase1, IL-1beta and IL-18.	K-115	12-21	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	142-147
32026851-7	2020	RKI-1447 reduced the levels of oxidative stress in HepG2 cells treated with oleic acid and significantly down-regulated the expression of RhoA, ROCK1, ROCK2, toll-like receptor 4 (TLR4), p-TBK1, and p-IRF3.	RKI-1447	0-8	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	151-156
32001136-2	2020	Structure-activity relationship studies of these compounds led to the identification of the most potent compound, 3-(3-methoxybenzyl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)thieno[2,3-d]pyrimidin-4(3H)-one (8k), which showed IC50 values of 0.004 muM and 0.001 muM against ROCK I and ROCK II, respectively.	N-methyl-3H-pyrrolo(2,3-d)pyrimidin-2(7H)-one	114-199	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	277-284
30860936-2	2019	Surprisingly, our recent study revealed that the ROCK2-specific inhibitor KD025 (SLx-2119), suppresses differentiation at the intermediate stage in 3T3-L1 preadipocytes.	KD025	74-79	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
32370715-0	2020	Upregulation of miR-496 rescues propofol-induced neurotoxicity by targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in prefrontal cortical neurons.	Propofol	32-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	76-130
32370715-0	2020	Upregulation of miR-496 rescues propofol-induced neurotoxicity by targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in prefrontal cortical neurons.	Propofol	32-40	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	132-137
32370715-11	2020	Besides, propofol increased the expression of ROCK2 through inhibiting miR-496 in PFC neurons.	Propofol	9-17	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	46-51
32370715-12	2020	Overexpression of miR-496 attenuated propofolinduced neurotoxicity by targeting ROCK2 in PFC neurons.	propofolinduced	37-52	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	80-85
32370715-13	2020	CONCLUSION: miR-496 was decreased in PFC neurons treated with propofol, and overexpression of miR-496 attenuated propofol-induced neurotoxicity by targeting ROCK2.	Propofol	62-70	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	157-162
32370715-13	2020	CONCLUSION: miR-496 was decreased in PFC neurons treated with propofol, and overexpression of miR-496 attenuated propofol-induced neurotoxicity by targeting ROCK2.	Propofol	113-121	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	157-162
32370715-14	2020	miR-496 and ROCK2 may be promising targets for protecting propofol-induced neurotoxicity.	Propofol	58-66	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	12-17
31955537-8	2019	Furthermore, treatment of chloroxoquinoline down-regulated the phosphorylation of the Rho/Rho kinase signaling proteins Cofilin, Limk and Rock2 (all P&lt;0.01).	chloroxoquinoline	26-43	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	138-143
31878963-13	2019	Moreover to inhibiting YAP activity, our findings indicate that verteporfin also affects the ROCK2 protein and its functions.	Verteporfin	64-75	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	93-98
30860936-7	2019	In addition, we observed that other ROCK inhibitors (Y-27632, fasudil, and H-1152P) did not suppress but promoted adipocyte differentiation.	Y 27632	53-60	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-40
30860936-7	2019	In addition, we observed that other ROCK inhibitors (Y-27632, fasudil, and H-1152P) did not suppress but promoted adipocyte differentiation.	fasudil	62-69	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-40
30860936-7	2019	In addition, we observed that other ROCK inhibitors (Y-27632, fasudil, and H-1152P) did not suppress but promoted adipocyte differentiation.	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	75-82	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-40
31599230-9	2019	Compared with the control group, the mRNA and protein expressions of RhoC, ROCK1, and ROCK2 in RPMI8226 and U266 cells were significantly decreased with single 5-Aza-Dc or TSA treatment.	decitabine	160-168	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	86-91
31330446-0	2019	Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.	3h-pyrazolo[4,3-f]quinoline boronic acid	53-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	94-98
31330446-2	2019	A few ROCK inhibitors, such as fasudil and netarsudil, are approved for clinical use.	fasudil	31-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	6-10
31330446-2	2019	A few ROCK inhibitors, such as fasudil and netarsudil, are approved for clinical use.	netarsudil	43-53	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	6-10
31330446-3	2019	Here we present a new ROCK inhibitor, boronic acid containing HSD1590, which is more potent than netarsudil at binding to or inhibiting ROCK enzymatic activities.	Boronic Acids	38-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-26
31330446-3	2019	Here we present a new ROCK inhibitor, boronic acid containing HSD1590, which is more potent than netarsudil at binding to or inhibiting ROCK enzymatic activities.	Boronic Acids	38-50	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	136-140
31330446-3	2019	Here we present a new ROCK inhibitor, boronic acid containing HSD1590, which is more potent than netarsudil at binding to or inhibiting ROCK enzymatic activities.	netarsudil	97-107	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-26
31330446-3	2019	Here we present a new ROCK inhibitor, boronic acid containing HSD1590, which is more potent than netarsudil at binding to or inhibiting ROCK enzymatic activities.	netarsudil	97-107	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	136-140
31330446-5	2019	Netarsudil, an FDA-approved drug, inhibited ROCK2 with IC50 = 11 nM under similar conditions).	netarsudil	0-10	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	44-49
31783584-0	2019	ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.	gemcitabine	23-34	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	0-5
31783584-2	2019	Here, we provide evidence that Rho associated coiled-coil containing protein kinase 2 (ROCK2) maintains gemcitabine resistance in gemcitabine resistant pancreatic cancer cells (GR cells).	gemcitabine	104-115	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-85
31783584-2	2019	Here, we provide evidence that Rho associated coiled-coil containing protein kinase 2 (ROCK2) maintains gemcitabine resistance in gemcitabine resistant pancreatic cancer cells (GR cells).	gemcitabine	104-115	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-92
31783584-2	2019	Here, we provide evidence that Rho associated coiled-coil containing protein kinase 2 (ROCK2) maintains gemcitabine resistance in gemcitabine resistant pancreatic cancer cells (GR cells).	gemcitabine	130-141	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	31-85
31783584-2	2019	Here, we provide evidence that Rho associated coiled-coil containing protein kinase 2 (ROCK2) maintains gemcitabine resistance in gemcitabine resistant pancreatic cancer cells (GR cells).	gemcitabine	130-141	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	87-92
31783584-3	2019	Pharmacological inhibition or gene silencing of ROCK2 markedly sensitized GR cells to gemcitabine by suppressing the expression of zinc-finger-enhancer binding protein 1 (ZEB1).	gemcitabine	86-97	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	48-53
31783584-4	2019	Mechanically, ROCK2-induced sp1 phosphorylation at Thr-453 enhanced the ability of sp1 binding to ZEB1 promoter regions in a p38-dependent manner.	peptide T amide	51-54	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	14-19
31783584-6	2019	Our findings demonstrate the essential role of ROCK2 in EMT-induced gemcitabine resistance in pancreatic cancer cells and provide strong evidence for the clinical application of fasudil, a ROCK2 inhibitor, in gemcitabine-refractory PDAC.	gemcitabine	68-79	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	47-52
31783584-6	2019	Our findings demonstrate the essential role of ROCK2 in EMT-induced gemcitabine resistance in pancreatic cancer cells and provide strong evidence for the clinical application of fasudil, a ROCK2 inhibitor, in gemcitabine-refractory PDAC.	fasudil	178-185	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	47-52
31783584-6	2019	Our findings demonstrate the essential role of ROCK2 in EMT-induced gemcitabine resistance in pancreatic cancer cells and provide strong evidence for the clinical application of fasudil, a ROCK2 inhibitor, in gemcitabine-refractory PDAC.	fasudil	178-185	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	189-194
31533472-9	2019	Moreover, emetine significantly reduced the protein levels of RhoA (Ras homolog gene family, member A), Rho-kinases (ROCK1 and ROCK2 [rho-associated coiled-coil containing protein kinases 1 and 2]), and their downstream CyPA (cyclophilin A), and Bsg (basigin) in PAH-PASMCs.	Emetine	10-17	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	127-132
31599230-9	2019	Compared with the control group, the mRNA and protein expressions of RhoC, ROCK1, and ROCK2 in RPMI8226 and U266 cells were significantly decreased with single 5-Aza-Dc or TSA treatment.	trichostatin A	172-175	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	86-91
31599230-11	2019	CONCLUSIONS We found that 5-Aza-Dc and TSA can effectively decrease the mRNA and protein expressions of RhoC, ROCK1, and ROCK2.	decitabine	26-34	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-126
31599230-11	2019	CONCLUSIONS We found that 5-Aza-Dc and TSA can effectively decrease the mRNA and protein expressions of RhoC, ROCK1, and ROCK2.	trichostatin A	39-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-126
31145917-8	2019	In WPMY-1, ICN relaxed cell contractions on collagen gels, disrupted F-actin organization, inhibited alpha1A-AR agonist-stimulated Ca2+ mobilization, and antagonized alpha1A-ARs via the RhoA/ROCK2/MLC signaling pathway.	corynoxeine	11-14	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	191-196
31187440-0	2019	Oxygen-Glucose Deprivation/Reoxygenation Induces Human Brain Microvascular Endothelial Cell Hyperpermeability Via VE-Cadherin Internalization: Roles of RhoA/ROCK2.	oxygen-glucose	0-14	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	157-162
31036319-9	2019	Besides, cell apoptosis rate, CD31-positive EMPs amount, TNF-alpha and IL-1beta concentrates, and ROCK II mRNA and protein levels in LPS + TMP group were significantly decreased when compared with LPS group.	tetramethylpyrazine	139-142	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	98-105
31396321-7	2019	Moreover, it promoted the expression of downstream Rho GTP signaling molecules, including PAK 1, ROCK 2, LIMK 1 and Cofilin.	Guanosine Triphosphate	55-58	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	97-103
31396321-8	2019	When PRP was used in combination with the Cdc 42 inhibitor ZCL278, the Rho A inhibitor CT04, Rac 1 inhibitor NSC23766, PAK inhibitor FRAX597, or Rock 2 inhibitor Y27632 to treat ADSCs, stress fiber formation was significantly reduced, resulting in decreased cell migration.	Y 27632	162-168	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	145-151
31036319-10	2019	To further confirm the mechanism, HUVECs in all the above groups were pretreated with Y27632 (ROCK II inhibitor) for 30 min before grouping, then treated as above.	Y 27632	86-92	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	94-101
30819619-0	2019	Discovery of (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide as potent and isoform selective ROCK2 inhibitors.	(s)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide	13-82	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	115-120
30819619-3	2019	In this work, a series of amide-chroman derivatives were synthesized and biologically evaluated in order to develop potent and isoform selective ROCK2 inhibitors.	Amides	26-31	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	145-150
30819619-4	2019	Remarkably, (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide ((S)-7c) possessed ROCK2 inhibitory activity with an IC50 value of 3 nM and 22.7-fold isoform selectivity (vs. ROCK1).	4-pyridin-4-yl-phenyl)-amide	53-81	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	101-106
30819619-3	2019	In this work, a series of amide-chroman derivatives were synthesized and biologically evaluated in order to develop potent and isoform selective ROCK2 inhibitors.	Chromans	32-39	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	145-150
30819619-4	2019	Remarkably, (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide ((S)-7c) possessed ROCK2 inhibitory activity with an IC50 value of 3 nM and 22.7-fold isoform selectivity (vs. ROCK1).	(s)-7c	83-89	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	101-106
30819619-6	2019	The binding free energies predicted by MM/GBSA were in good agreement with the experimental bioactivities, and the analysis of individual energy terms suggested that residue Lys105 in ROCK1 or Lys121 in ROCK2 was the key residue for the isoform selectivity of (S)-7c.	(s)-7c	260-266	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	203-208
30819619-4	2019	Remarkably, (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide ((S)-7c) possessed ROCK2 inhibitory activity with an IC50 value of 3 nM and 22.7-fold isoform selectivity (vs. ROCK1).	(s)-6-methoxy-chroman-3-carboxylic acid	12-51	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	101-106
29669760-2	2018	The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton.	AT13148	46-53	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	82-87
30556245-0	2019	The novel protective effects of loganin against 1-methyl-4-phenylpyridinium-induced neurotoxicity: Enhancement of neurotrophic signaling, activation of IGF-1R/GLP-1R, and inhibition of RhoA/ROCK pathway.	loganin	32-39	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	190-194
30556245-7	2019	Moreover, loganin attenuated MPP+ -induced neurite damage via up-regulation of GAP43 and down-regulation of membrane-RhoA/ROCK2/p-LIMK/p-cofilin.	loganin	10-17	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-127
30556245-7	2019	Moreover, loganin attenuated MPP+ -induced neurite damage via up-regulation of GAP43 and down-regulation of membrane-RhoA/ROCK2/p-LIMK/p-cofilin.	mangion-purified polysaccharide (Candida albicans)	29-33	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-127
30556245-10	2019	Our results suggest that loganin attenuates MPP+ -induced apoptotic death, neurite damage, and oxidative stress through enhancement of neurotrophic signaling, activation of IGF-1R/GLP-1R, and inhibition of RhoA/ROCK pathway, providing the evidence that loganin possesses novel neuroprotective effects.	loganin	25-32	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	211-215
30556245-10	2019	Our results suggest that loganin attenuates MPP+ -induced apoptotic death, neurite damage, and oxidative stress through enhancement of neurotrophic signaling, activation of IGF-1R/GLP-1R, and inhibition of RhoA/ROCK pathway, providing the evidence that loganin possesses novel neuroprotective effects.	mangion-purified polysaccharide (Candida albicans)	44-48	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	211-215
30384606-8	2018	Finally, the cocrystal structures also identified that aspartic acid residues 176 and 218 in ROCK2, which are glutamic acids in PKA, could be targeted as residues to drive both potency and kinome selectivity.	Aspartic Acid	55-68	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	93-98
30384606-8	2018	Finally, the cocrystal structures also identified that aspartic acid residues 176 and 218 in ROCK2, which are glutamic acids in PKA, could be targeted as residues to drive both potency and kinome selectivity.	Glutamates	110-124	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	93-98
30433799-8	2019	However, Y-27632, a Rho kinase inhibitor, increased phosphorylation of Pyk2 at Tyr402 and concomitantly decreased ROCK2 levels; the expression of MLCK in CSMCs did not change.	Y 27632	9-16	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	114-119
30433799-9	2019	The expression of P(Tyr402)-Pyk2 and ROCK2 was increased when CSMCs were treated with Ach.	Acetylcholine	86-89	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	37-42
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Furosemide	21-31	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	164-169
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Furosemide	21-31	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	285-290
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Triamterene	36-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	164-169
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Triamterene	36-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	285-290
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Triamterene	124-135	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	164-169
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	Triamterene	124-135	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	285-290
30866733-6	2019	It is found that the Furosemide and Triamterene have significant cytotoxic effects on normal human astrocytes, in which the Triamterene can inhibit the neurokinase ROCK2, a representative of putative unexpected targets, with a high activity, which is comparable with the sophisticated ROCK2 inhibitor Fasudil.	fasudil	301-308	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	164-169
30848208-7	2019	RESULTS: Results of the docked conformations suggested that introduction of non-bulky and substituted groups in the hinge region of ROCK-II ATP binding pocket would improve the activity by decreasing the bulkiness or length of the compounds.	Adenosine Triphosphate	140-143	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	132-139
30098001-0	2018	The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6.	KD025	30-35	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	14-19
30098001-3	2018	We reported here that the selective ROCK2 inhibitor KD025 significantly reduced in vitro production of IL-17 in unfractionated human peripheral blood mononuclear cells (PBMCs) stimulated with the dectin-1 agonist Candida albicans.	KD025	52-57	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-41
29932921-4	2018	Overexpression of ROCK2 significantly attenuated the inhibitory effects of miR-455-3p on cell proliferation, extracellular matrix (ECM) synthesis and epithelial-mesenchymal transition (EMT) in HG-treated cells.	mir-455-3p	75-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	18-23
29766980-0	2018	Ripasudil Attenuates Lipopolysaccharide (LPS)-Mediated Apoptosis and Inflammation in Pulmonary Microvascular Endothelial Cells via ROCK2/eNOS Signaling.	K-115	0-9	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	131-136
29219208-11	2018	miR-484 regulated the expression of ROCK2.	mir-484	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	36-41
29655979-1	2018	During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.	dihydropyridopyrimidinones	137-163	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	250-255
29655979-1	2018	During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.	dhp	165-168	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	250-255
29660437-7	2018	We further assessed the effect of DCG on ROCK pathway.	Glycodeoxycholic Acid	34-37	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	41-45
29660437-8	2018	In beta-escin-permeabilized arteries, DCG reduced high-dose Ca2+- and GTPgammaS (a ROCK activator)-induced vasoconstriction.	Glycodeoxycholic Acid	38-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	83-87
29660437-12	2018	In conclusion, DCG attenuates vascular Ca2+ sensitivity and tone via inhibiting ROCK pathway.	Glycodeoxycholic Acid	15-18	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	80-84
29766980-2	2018	Ripasudil is a novel Rho/Rho kinase (ROCK) inhibitor which shows therapeutic effects on several vascular diseases.	K-115	0-9	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	37-41
29766980-12	2018	Ripasudil suppressed ROCK2 activity and further increased the eNOS activity.	K-115	0-9	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	21-26
29766980-16	2018	CONCLUSIONS The novel ROCK2 inhibitor ripasudil suppressed LPS-induced apoptosis and inflammation in PMVECs by regulating the ROCK2/eNOS signaling pathway.	K-115	38-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	22-27
29766980-16	2018	CONCLUSIONS The novel ROCK2 inhibitor ripasudil suppressed LPS-induced apoptosis and inflammation in PMVECs by regulating the ROCK2/eNOS signaling pathway.	K-115	38-47	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	126-131
28653604-10	2018	Rescue experiments showed that overexpression of ROCK2 effectively reversed the inhibitory effect of OC cells induced by miR-139-5p.	mir-139-5p	121-131	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
29338098-7	2018	In addition, melatonin decreases nicotine-dependent ROCK1/ROCK2 activation, thus further inhibiting cell contractility and motility.	Melatonin	13-22	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	58-63
29338098-7	2018	In addition, melatonin decreases nicotine-dependent ROCK1/ROCK2 activation, thus further inhibiting cell contractility and motility.	Nicotine	33-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	58-63
29416017-0	2018	Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.	fasudil	0-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-115
29420299-2	2018	We report here that, during mitosis progression, ARHGAP19 is sequentially phosphorylated by the RhoA-activated kinases ROCK1 and ROCK2 (hereafter ROCK) on serine residue 422, and by CDK1 on threonine residues 404 and 476.	Serine	155-161	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	129-134
28873499-1	2018	Mobilization of Chloroethene Compounds from the Rock Matrix.	Vinyl Chloride	16-28	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	48-52
28873499-2	2018	A mass balance is formulated to evaluate the mobilization of chlorinated ethene compounds (CE) from the rock matrix of a fractured mudstone aquifer under pre- and postbioremediation conditions.	ethene compounds	73-89	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	104-108
29416017-2	2018	Here, we provided evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas, and as a ROCK2 phosphorylation inhibitor, fasudil significantly suppressed proliferation of TMZ-resistant gliomas in vivo and vitro via enhancing the chemosensitivity of TMZ.	Temozolomide	82-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	32-37
29416017-2	2018	Here, we provided evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas, and as a ROCK2 phosphorylation inhibitor, fasudil significantly suppressed proliferation of TMZ-resistant gliomas in vivo and vitro via enhancing the chemosensitivity of TMZ.	fasudil	154-161	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	32-37
29416017-2	2018	Here, we provided evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas, and as a ROCK2 phosphorylation inhibitor, fasudil significantly suppressed proliferation of TMZ-resistant gliomas in vivo and vitro via enhancing the chemosensitivity of TMZ.	fasudil	154-161	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-126
29416017-2	2018	Here, we provided evidence that ROCK2 acted redundantly to maintain resistance of TMZ in TMZ-resistant gliomas, and as a ROCK2 phosphorylation inhibitor, fasudil significantly suppressed proliferation of TMZ-resistant gliomas in vivo and vitro via enhancing the chemosensitivity of TMZ.	Temozolomide	89-92	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	32-37
29416017-4	2018	We also showed that fasudil suppressed the expression of ABCG2 via ROCK2/moesin/beta-catenin pathway.	fasudil	20-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	67-72
29886836-9	2018	In addition, myricetin could inhibit PI3K/Akt and JNK signaling, and bind to a series of kinases and scaffold proteins including PI3K catalytic isoforms (p110alpha, p110beta and p110delta), PDK1, JNK, c-Jun, ROCK2, paxillin, vinculin and VEcadherin.	myricetin	13-22	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	208-213
29434937-12	2018	However, a significant increase in invasion was observed after treatment with SR3677 (ROCK2 inhibitor) and hydroxyfasudil (pan-inhibitor).	SR-3677	78-84	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	86-91
28389592-2	2017	In this study, we report that oral administration of a selective ROCK2 inhibitor, KD025, reduces psoriasis area and severity index scores by 50% from baseline in 46% of patients with psoriasis vulgaris, and it decreases epidermal thickness as well as T cell infiltration in the skin.	KD025	82-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	65-70
29152648-8	2017	The results revealed that the expression levels of ROCK2, p-MYPT1 and p-MLC in RKO cells were decreased, and the membrane protein expression of ZO-1 and occludin increased when the cells were treated with melatonin.	Melatonin	205-214	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	51-56
29152648-9	2017	qPCR demonstrated that melatonin downregulated ROCK2 gene expression, and upregulated the expression of the ZO-1 and occludin genes.	Melatonin	23-32	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	47-52
28956212-5	2017	After inhibition of ROCK-2 with Y27632 for 24 h, no caveolae-mediated micropillar assembly of the cell membrane domain component caveolin-1 (Cav-1) was found.	Y 27632	32-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	20-26
28510599-2	2017	While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selective ROCK-2 inhibition may overcome these limitations.	fasudil	51-58	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	237-243
29153889-0	2017	3D-QSAR studies on indole and 7-azoindole derivatives as ROCK-2 inhibitors: An integrative computational approach.	indole	19-25	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	57-63
29153889-0	2017	3D-QSAR studies on indole and 7-azoindole derivatives as ROCK-2 inhibitors: An integrative computational approach.	7-azoindole	30-41	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	57-63
29153889-3	2017	In this study, we have performed pharmacophore modeling and 3D QSAR studies on a series of 36 indoles and 7-azoindoles derivatives as ROCK2 inhibitors to elucidate the structural variations with their inhibitory activities.	Indoles	94-101	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-139
29153889-3	2017	In this study, we have performed pharmacophore modeling and 3D QSAR studies on a series of 36 indoles and 7-azoindoles derivatives as ROCK2 inhibitors to elucidate the structural variations with their inhibitory activities.	7-azoindoles	106-118	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-139
29033348-4	2017	The nitrophenyl piperazine substituted compound 9j exhibited significant IOP lowering (51.56%) and an inhibition of 57.25 and 77.92% towards ROCK II enzyme at a concentration of 0.5 and 1 mM respectively.	nitrophenyl piperazine	4-26	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	141-148
28284870-5	2017	The structure-activity relationship (SAR) studies resulted in the discovery of new, potent, and selective Cdc7 inhibitors 14a, c, e. Furthermore, the high selectivity of 14c, e for Cdc7 over Rho-associated protein kinase 1 (ROCK1) is discussed by utilizing a docking study with Cdc7 and ROCK2 crystal structures.	Carbon-14	170-173	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	287-292
28283529-10	2017	Th17 cells exhibited high ROCK activity that was inhibited by Y27632, KD025 or simvastatin; each also decreased IL-17 and IL-21 production by purified SLE T cells or Th17 cells.	Simvastatin	79-90	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	26-30
28191463-0	2017	Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression.	Doxorubicin	31-42	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	70-75
28191463-6	2017	Knockdown of ROCK2 expression or pharmacological inhibition of ROCK decreased doxorubicin-induced p53 activation.	Doxorubicin	78-89	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	13-18
27432870-6	2016	Both CN-03- and Ang II-induced endothelial dysfunction was prevented by Y-27632 (an inhibitor of both ROCK isoforms) or the selective ROCK2 inhibitor SLX-2119.	KD025	150-158	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-139
28484287-1	2017	miR-135a-5p was reported to play a crucial role in the protective effects of hydrogen sulfide against Parkinson"s disease (PD) by targeting rho-associated protein kinase 2 (ROCK2).	Hydrogen Sulfide	77-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	140-171
28484287-1	2017	miR-135a-5p was reported to play a crucial role in the protective effects of hydrogen sulfide against Parkinson"s disease (PD) by targeting rho-associated protein kinase 2 (ROCK2).	Hydrogen Sulfide	77-93	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	173-178
27229528-0	2016	Downregulation of miR-101 contributes to epithelial-mesenchymal transition in cisplatin resistance of NSCLC cells by targeting ROCK2.	mir-101	18-25	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	127-132
27354305-5	2016	Through the combined virtual and high-content drug screening, the compound 1,3-benzodioxol-5-yl[1-(5-isoquinolinylmethyl)-3-piperidinyl]-methanone (BIPM) was identified as a novel and potent ROCK2 inhibitor.	3-benzodioxol-5-yl[1-(5-isoquinolinylmethyl)-3-piperidinyl]-methanone	77-146	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	191-196
27354305-5	2016	Through the combined virtual and high-content drug screening, the compound 1,3-benzodioxol-5-yl[1-(5-isoquinolinylmethyl)-3-piperidinyl]-methanone (BIPM) was identified as a novel and potent ROCK2 inhibitor.	N-[4-(2-Benzimidazolyl)phenyl]maleimide	148-152	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	191-196
27288754-0	2016	Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo.	Saponins	18-26	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	75-80
27288754-3	2016	AIMS OF THE STUDY: This study explored whether panax notoginseng saponins (PNS) provided neuroprotective effects by inhibiting the expressions of NgR1, RhoA, and ROCK2 following middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) injury in SH-SY5Y cells.	Saponins	65-73	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	162-167
27288754-3	2016	AIMS OF THE STUDY: This study explored whether panax notoginseng saponins (PNS) provided neuroprotective effects by inhibiting the expressions of NgR1, RhoA, and ROCK2 following middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation (OGD/R) injury in SH-SY5Y cells.	4'-phosphopantetheine	75-78	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	162-167
27288754-12	2016	PNS and N+P treatment significantly decreased NgR1, RhoA, and ROCK2 overexpression compared with the model group.	n+p	8-11	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	62-67
27229528-0	2016	Downregulation of miR-101 contributes to epithelial-mesenchymal transition in cisplatin resistance of NSCLC cells by targeting ROCK2.	Cisplatin	78-87	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	127-132
27229528-4	2016	Restoration of miR-101 expression inhibited EMT and increased the sensitivity of cisplatin-resistant NSCLC cells to cisplatin in vitro by targeting ROCK2.	mir-101	15-22	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	148-153
27229528-4	2016	Restoration of miR-101 expression inhibited EMT and increased the sensitivity of cisplatin-resistant NSCLC cells to cisplatin in vitro by targeting ROCK2.	Cisplatin	81-90	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	148-153
27229528-4	2016	Restoration of miR-101 expression inhibited EMT and increased the sensitivity of cisplatin-resistant NSCLC cells to cisplatin in vitro by targeting ROCK2.	Cisplatin	116-125	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	148-153
27229528-5	2016	Furthermore, ROCK2 protein level was inversely correlated with miR-101 level in NSCLC tissue samples.	mir-101	63-70	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	13-18
27229528-7	2016	In summary, our results provide novel mechanistic insights into the role of miR-101/ROCK2 signaling in the cisplatin resistance of NSCLC cells.	mir-101	76-83	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	84-89
27229528-7	2016	In summary, our results provide novel mechanistic insights into the role of miR-101/ROCK2 signaling in the cisplatin resistance of NSCLC cells.	Cisplatin	107-116	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	84-89
27123784-0	2016	Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration.	Atorvastatin	0-12	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	117-122
27284349-4	2016	The results of western blotting and reverse transcription-quantitative polymerase chain reaction analysis showed that hypoxia increased the activity and expression of ROCK2 in PAECs, and the stimulating effects of hypoxia on the proliferation of PAECs were attenuated by either the ROCK inhibitor Y27632 or transfection with ROCK2 small interfering RNA.	Y 27632	297-303	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	167-172
27017918-6	2016	Observation of ROCK II cleavage after ouabain, digoxin and oxaliplatin treatments in HeLa and/or HepG2 cells suggested that cleavage is independent of cell type and cell death induction.	Digoxin	47-54	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	15-22
27017918-6	2016	Observation of ROCK II cleavage after ouabain, digoxin and oxaliplatin treatments in HeLa and/or HepG2 cells suggested that cleavage is independent of cell type and cell death induction.	Oxaliplatin	59-70	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	15-22
27017918-7	2016	While inhibiting cleavage of ROCK II by the caspase inhibitors z-VAD-fmk, z-VDVAD-fmk and z-DEVD-fmk, evaluation of caspase 2 siRNA ineffectiveness on this truncation indicated that caspase-dependent ROCK II cleavage is differentially regulated in cancer cell lines.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	63-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-36
27017918-7	2016	While inhibiting cleavage of ROCK II by the caspase inhibitors z-VAD-fmk, z-VDVAD-fmk and z-DEVD-fmk, evaluation of caspase 2 siRNA ineffectiveness on this truncation indicated that caspase-dependent ROCK II cleavage is differentially regulated in cancer cell lines.	benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone	74-85	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-36
27017918-7	2016	While inhibiting cleavage of ROCK II by the caspase inhibitors z-VAD-fmk, z-VDVAD-fmk and z-DEVD-fmk, evaluation of caspase 2 siRNA ineffectiveness on this truncation indicated that caspase-dependent ROCK II cleavage is differentially regulated in cancer cell lines.	benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone	90-100	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	29-36
27123784-0	2016	Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration.	Metformin	18-27	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	117-122
27123784-13	2016	CONCLUSION: In subjects with dyslipidemia and overweight/obese, atorvastatin plus metformin may confer additive benefits through reducing leukocyte ROCK2 concentration.	Atorvastatin	64-76	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	148-153
27123784-13	2016	CONCLUSION: In subjects with dyslipidemia and overweight/obese, atorvastatin plus metformin may confer additive benefits through reducing leukocyte ROCK2 concentration.	Metformin	82-91	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	148-153
26882474-6	2016	Given that CS has been reported to increase ROCK activity in endothelial cells, here we investigated the effects of CS on the ROCK2-IRF4 axis in T cells.	Cesium	11-13	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	44-48
26882474-7	2016	Surprisingly, we found that CS leads to decreased ROCK2 activation and IRF4 phosphorylation in T cells.	Cesium	28-30	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	50-55
26882474-9	2016	Using a GEF pull-down assay we furthermore identify ARHGEF1 as a key upstream regulator of ROCK2 whose activity in T cells is inhibited by CS.	Cesium	139-141	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	91-96
26882474-10	2016	Thus CS can inhibit the ROCK2-IRF4 axis and modulate T cell production of IL-22.	Cesium	5-7	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	24-29
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	77-82
26901778-6	2016	The acid-induced increase in NOX5-S expression and H2O2 production was significantly decreased by knockdown of Rho kinase ROCK2, but not by knockdown of ROCK1.	Hydrogen Peroxide	51-55	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-127
26901778-7	2016	Conversely, the overexpression of the constitutively active ROCK2, but not the constitutively active ROCK1, significantly enhanced the NOX5-S expression and H2O2 production.	Hydrogen Peroxide	157-161	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	60-65
26568398-4	2015	Results from Human Umbilical Vein Endothelial Cells (HUVEC) by using real-time migration xCELLigence system, immunofluorescence and western blotting provided strong evidences of formononetin induced endothelial cell migration and dramatic actin cytoskeleton spatial modification through ERalpha-enhanced-ROCK-II/MMP2/9 signaling pathways.	formononetin	178-190	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	304-311
26545798-0	2015	Discovery of bis-aryl urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study.	bis-aryl urea	13-26	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	115-120
26568398-5	2015	In addition, results from co-immunoprecipitation suggested formononetin induced cell migration via recruiting of ERalpha/ROCK-II activated complex formation.	formononetin	59-71	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-128
26568398-7	2015	In this study, we elucidated the underlying mechanisms that formononetin produced proangiogenesis effects through an ERalpha-enhanced ROCK-II signaling pathways.	formononetin	60-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	134-141
25940707-4	2015	Here we demonstrate that treatment of human uterine smooth muscle cells (SMCs) of the JZ with 17beta-estradiol (E2) increased expression of RhoA and its downstream effectors (-associated coiled coil containing protein kinase [ROCK] 1 and ROCK2).	Estradiol	94-110	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	238-243
26351364-6	2015	In HepG2 cells incubated with serum or exogenous mevalonate, KMUP-1 (10(-7)~10(-5) M) reversed HMGR expression by feedback regulation, colocalized expression of ABCA1/apolipoprotein A-I/LXRalpha/PPARgamma, and reduced exogenous geranylgeranyl pyrophosphate/farnesyl pyrophosphate (FPP)-induced RhoA/ROCK II expression.	Mevalonic Acid	49-59	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	299-306
26351364-7	2015	A guanosine 3",5"-cyclic monophosphate (cGMP) antagonist reversed KMUP-1-induced ROCK II reduction, indicating cGMP/eNOS involvement.	Cyclic GMP	2-38	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	81-88
26351364-7	2015	A guanosine 3",5"-cyclic monophosphate (cGMP) antagonist reversed KMUP-1-induced ROCK II reduction, indicating cGMP/eNOS involvement.	Cyclic GMP	40-44	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	81-88
26351364-7	2015	A guanosine 3",5"-cyclic monophosphate (cGMP) antagonist reversed KMUP-1-induced ROCK II reduction, indicating cGMP/eNOS involvement.	KMUP 1	66-72	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	81-88
26344760-7	2015	In contrast, lysophosphatidic acid (LPA) induces ROCK2 kinase, which suppresses neurite outgrowth from round cells via A-type phosphorylation.	lysophosphatidic acid	13-34	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
26276827-9	2015	A ROCK2 inhibitor, SR3677, reduced contractile forces in primary human airway smooth muscle cells, confirming a role for ROCK2 in airway smooth muscle contraction.	SR-3677	19-25	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	2-7
26276827-9	2015	A ROCK2 inhibitor, SR3677, reduced contractile forces in primary human airway smooth muscle cells, confirming a role for ROCK2 in airway smooth muscle contraction.	SR-3677	19-25	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	121-126
26344760-7	2015	In contrast, lysophosphatidic acid (LPA) induces ROCK2 kinase, which suppresses neurite outgrowth from round cells via A-type phosphorylation.	lysophosphatidic acid	36-39	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	49-54
26233434-4	2015	Exploration of structure-activity relationships revealed that many of such compounds, including LX-7101, cause potent inhibition of LIMK1 and LIMK2, and also ROCK2 and PKA.	LX-7101	96-103	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	158-163