PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
24513077-0	2013	[Influence of zoledronate on osteoclast differentiation and gene expression of calmodulin and calmodulin-dependent protein kinase II].	Zoledronic Acid	14-25	calmodulin 2	Mus musculus	79-89
24513077-0	2013	[Influence of zoledronate on osteoclast differentiation and gene expression of calmodulin and calmodulin-dependent protein kinase II].	Zoledronic Acid	14-25	calmodulin 2	Mus musculus	94-104
23115171-4	2012	An abundance of evidence indicates that CDI relies upon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1.2 L-type channels, a molecular mechanism seemingly unrelated to phosphorylation-mediated channel enhancement.	1,1'-Carbonyldiimidazole	40-43	calmodulin 2	Mus musculus	74-84
23731236-9	2013	The effects of inosine on ACh release were prevented by the Gi/o protein inhibitor N-ethylmaleimide, PKC antagonist chelerytrine and calmodulin antagonist W-7, but not by PKA antagonists, H-89 and KT-5720, or the inhibitor of CaMKII KN-62.	Inosine	15-22	calmodulin 2	Mus musculus	133-143
23731236-9	2013	The effects of inosine on ACh release were prevented by the Gi/o protein inhibitor N-ethylmaleimide, PKC antagonist chelerytrine and calmodulin antagonist W-7, but not by PKA antagonists, H-89 and KT-5720, or the inhibitor of CaMKII KN-62.	Acetylcholine	26-29	calmodulin 2	Mus musculus	133-143
23653405-0	2013	Protein fishing using magnetic nanobeads containing calmodulin site-specifically immobilized via an azido group.	3',5-diazido-2',3'-dideoxyuridine	100-105	calmodulin 2	Mus musculus	52-62
23653405-3	2013	Using calmodulin (CaM) as the target protein, we introduced N3-Y at position 72 and conjugated it to FG beads by copper-free click chemistry.	Copper	113-119	calmodulin 2	Mus musculus	18-21
23731236-9	2013	The effects of inosine on ACh release were prevented by the Gi/o protein inhibitor N-ethylmaleimide, PKC antagonist chelerytrine and calmodulin antagonist W-7, but not by PKA antagonists, H-89 and KT-5720, or the inhibitor of CaMKII KN-62.	Tungsten	155-156	calmodulin 2	Mus musculus	133-143
23370391-6	2013	The calmodulin inhibitor, calmidazolium, reduced Aurora B protein levels resulting in tetraploidy, mitotic arrest, and apoptosis of tumorigenic cells and profoundly inhibiting tumor formation in athymic nude mice.	calmidazolium	26-39	calmodulin 2	Mus musculus	4-14
23115171-4	2012	An abundance of evidence indicates that CDI relies upon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1.2 L-type channels, a molecular mechanism seemingly unrelated to phosphorylation-mediated channel enhancement.	1,1'-Carbonyldiimidazole	40-43	calmodulin 2	Mus musculus	86-89
23115171-4	2012	An abundance of evidence indicates that CDI relies upon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1.2 L-type channels, a molecular mechanism seemingly unrelated to phosphorylation-mediated channel enhancement.	Glutamine	108-117	calmodulin 2	Mus musculus	74-84
23115171-4	2012	An abundance of evidence indicates that CDI relies upon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1.2 L-type channels, a molecular mechanism seemingly unrelated to phosphorylation-mediated channel enhancement.	Glutamine	108-117	calmodulin 2	Mus musculus	86-89
23115171-5	2012	But our work reveals, in cultured hippocampal neurons and a heterologous expression system, that the Ca(2+)/CaM-activated phosphatase calcineurin (CaN) is scaffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of an AKAP79/150 mutant incapable of binding CaN (DeltaPIX; CaN-binding PXIXIT motif deleted) impedes CDI.	deltapix	307-315	calmodulin 2	Mus musculus	108-111
23115171-5	2012	But our work reveals, in cultured hippocampal neurons and a heterologous expression system, that the Ca(2+)/CaM-activated phosphatase calcineurin (CaN) is scaffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of an AKAP79/150 mutant incapable of binding CaN (DeltaPIX; CaN-binding PXIXIT motif deleted) impedes CDI.	pxixit	329-335	calmodulin 2	Mus musculus	108-111
23115171-5	2012	But our work reveals, in cultured hippocampal neurons and a heterologous expression system, that the Ca(2+)/CaM-activated phosphatase calcineurin (CaN) is scaffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of an AKAP79/150 mutant incapable of binding CaN (DeltaPIX; CaN-binding PXIXIT motif deleted) impedes CDI.	1,1'-Carbonyldiimidazole	359-362	calmodulin 2	Mus musculus	108-111
23115171-8	2012	Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA inhibitor PKI suggest that Ca(2+)/CaM-activated CaN promotes CDI by reversing channel enhancement effectuated by kinases such as PKA.	Colforsin	60-69	calmodulin 2	Mus musculus	121-124
23115171-8	2012	Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA inhibitor PKI suggest that Ca(2+)/CaM-activated CaN promotes CDI by reversing channel enhancement effectuated by kinases such as PKA.	1,1'-Carbonyldiimidazole	148-151	calmodulin 2	Mus musculus	121-124
23115171-9	2012	Hence, our investigation of AKAP79/150-anchored CaN reconciles the CaM-based model of CDI with an earlier, seemingly contradictory model based on dephosphorylation signaling.	1,1'-Carbonyldiimidazole	86-89	calmodulin 2	Mus musculus	67-70
22170035-6	2012	Syringaresinol-induced AMPK activation was inhibited by co-treatment with PLC inhibitor, Ca(2+) chelator, calmodulin antagonist, and CaMKKbeta siRNA.	syringaresinol	0-14	calmodulin 2	Mus musculus	106-116
22437841-0	2012	Expression of calmodulin in germ cells is associated with fenvalerate-induced male reproductive toxicity.	fenvalerate	58-69	calmodulin 2	Mus musculus	14-24
22437841-3	2012	The present study explored the effects of fenvalerate on the expression of calmodulin in mouse testis and GC-2spd(ts) cells, and its association with fenvalerate-induced male reproductive toxicity.	fenvalerate	42-53	calmodulin 2	Mus musculus	75-85
22437841-10	2012	Meanwhile, both mRNA and protein expression of calmodulin were significantly increased in the testes of mice exposed to fenvalerate compared to control mice.	fenvalerate	120-131	calmodulin 2	Mus musculus	47-57
22437841-11	2012	Moreover, in the in vitro study, 5 muM fenvalerate significantly increased the expression of calmodulin at the mRNA and protein levels in GC-2spd(ts) cells after 8 h of incubation and sustained these levels for at least 24 h. Collectively, these data suggested that enhanced expression of calmodulin correlates with male reproductive damage induced by fenvalerate.	fenvalerate	39-50	calmodulin 2	Mus musculus	93-103
22437841-11	2012	Moreover, in the in vitro study, 5 muM fenvalerate significantly increased the expression of calmodulin at the mRNA and protein levels in GC-2spd(ts) cells after 8 h of incubation and sustained these levels for at least 24 h. Collectively, these data suggested that enhanced expression of calmodulin correlates with male reproductive damage induced by fenvalerate.	fenvalerate	39-50	calmodulin 2	Mus musculus	289-299
22437841-11	2012	Moreover, in the in vitro study, 5 muM fenvalerate significantly increased the expression of calmodulin at the mRNA and protein levels in GC-2spd(ts) cells after 8 h of incubation and sustained these levels for at least 24 h. Collectively, these data suggested that enhanced expression of calmodulin correlates with male reproductive damage induced by fenvalerate.	fenvalerate	352-363	calmodulin 2	Mus musculus	93-103
21325494-6	2011	Calmodulin inhibitor W-7 markedly reduced ANG II- and/or dDAVP-stimulated AQP2 expression.	W 7	21-24	calmodulin 2	Mus musculus	0-10
22759973-5	2012	Angiotensin II (AII) via stimulation of Ca(2+)/calmodulin increased ASP(+)-uptake.	Aspartic Acid	68-74	calmodulin 2	Mus musculus	47-57
21320072-3	2011	Elevations in intracellular Ca2+ concentration effected a 95% decline in gj (junctional conductance) of Cx50 in N2a cells that is likely to be mediated by CaM, because inclusion of the CaM inhibitor calmidazolium prevented this Ca2+-dependent decrease in gj.	calmidazolium	199-212	calmodulin 2	Mus musculus	155-158
21320072-3	2011	Elevations in intracellular Ca2+ concentration effected a 95% decline in gj (junctional conductance) of Cx50 in N2a cells that is likely to be mediated by CaM, because inclusion of the CaM inhibitor calmidazolium prevented this Ca2+-dependent decrease in gj.	calmidazolium	199-212	calmodulin 2	Mus musculus	185-188
21516261-0	2011	Calcium-Sensitive Translocation of Calmodulin and Neurogranin between Soma and Dendrites of Mouse Hippocampal CA1 Neurons.	Calcium	0-7	calmodulin 2	Mus musculus	35-45
21410792-4	2011	In control mice, treatment with the calmodulin antagonist calmidazolium (5 mum) impaired PPF and LTD.	calmidazolium	58-71	calmodulin 2	Mus musculus	36-46
21436055-0	2011	Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.	Alcohols	28-35	calmodulin 2	Mus musculus	0-10
21436055-7	2011	The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide.	Ethanol	89-96	calmodulin 2	Mus musculus	19-29
21436055-7	2011	The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide.	Ethanol	89-96	calmodulin 2	Mus musculus	197-207
21436055-7	2011	The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide.	Calcium	4-11	calmodulin 2	Mus musculus	19-29
21436055-7	2011	The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide.	Calcium	4-11	calmodulin 2	Mus musculus	197-207
21436055-8	2011	A calmodulin activator virtually abolished the modest ethanol effects in intact cells.	Ethanol	54-61	calmodulin 2	Mus musculus	2-12
21436055-12	2011	Calmodulin protects by reducing calcium release sensitivity.	Calcium	32-39	calmodulin 2	Mus musculus	0-10
21115851-8	2011	Openers of small- and intermediate-conductance Ca(2+)-activated potassium channels known to interact with calmodulin, such as 1-EBIO, DCEBIO, or riluzole, also activated TMEM16A.	5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one	134-140	calmodulin 2	Mus musculus	106-116
21115851-8	2011	Openers of small- and intermediate-conductance Ca(2+)-activated potassium channels known to interact with calmodulin, such as 1-EBIO, DCEBIO, or riluzole, also activated TMEM16A.	Riluzole	145-153	calmodulin 2	Mus musculus	106-116
21485083-10	2011	CONCLUSION: Curcumin could improve learning and memory Ca2+/capacities of SAM by lowering hippocampal [Ca2+] overload, increase the hippocampal CaM mRNA level and CaMK II expression in the hippocampal dose-dependently.	Curcumin	12-20	calmodulin 2	Mus musculus	144-147
20339514-5	2010	We confirmed that CAM to TV ratio fairly represented secretory activity in untreated and secretion-inhibited wild-type (WT) mice and in NHE2-/- mice as well, though the response was significantly attenuated in the latter.	tetrazolium violet	25-27	calmodulin 2	Mus musculus	18-21
20226167-8	2010	In saponin-permeabilized cardiomyocytes, the addition of cAMP increased the frequency of spontaneous Ca(2+) sparks to a significantly larger extent in KI cardiomyocytes than in WT cardiomyocytes, whereas the addition of a high concentration of CaM attenuated the aberrant increase of Ca(2+) sparks.	Cyclic AMP	57-61	calmodulin 2	Mus musculus	244-247
20007969-3	2010	The adjacent end of alpha-spectrin, called the EF-domain, is calmodulin-like, with calcium-dependent and calcium-independent EF-hands.	Calcium	83-90	calmodulin 2	Mus musculus	61-71
20007969-3	2010	The adjacent end of alpha-spectrin, called the EF-domain, is calmodulin-like, with calcium-dependent and calcium-independent EF-hands.	Calcium	105-112	calmodulin 2	Mus musculus	61-71
20054830-8	2010	Tryptophan fluorescence experiments were used to study the interactions between Mg(2+)-sCaM4 and CaM-binding peptides derived from smooth muscle myosin light chain kinase and plant glutamate decarboxylase.	Tryptophan	0-10	calmodulin 2	Mus musculus	88-91
20054830-8	2010	Tryptophan fluorescence experiments were used to study the interactions between Mg(2+)-sCaM4 and CaM-binding peptides derived from smooth muscle myosin light chain kinase and plant glutamate decarboxylase.	magnesium ion	80-86	calmodulin 2	Mus musculus	88-91
19336226-0	2009	Aquaporin 6 binds calmodulin in a calcium-dependent manner.	Calcium	34-41	calmodulin 2	Mus musculus	18-28
19523924-5	2009	Invivo, Ligustrazine reduced the Hb content in a Matrigel plug implanted in mice and inhibited new vessel formation in CAM.	tetramethylpyrazine	8-20	calmodulin 2	Mus musculus	119-122
19326139-6	2009	Proteasome inhibition (MG-132) and calmodulin antagonism (calmidazolium) also inhibited this conversion suggesting that other protein degradation pathways also are in play.	calmidazolium	58-71	calmodulin 2	Mus musculus	35-45
19228732-12	2009	Overexpression of c-FLIP inhibited tamoxifen-induced apoptosis and enhanced tumorigenesis of cholangiocarcinoma cells in nude mice, whereas deletion of the calmodulin-binding domain on c-FLIP restored the sensitivity to tamoxifen and inhibited tumorigenesis.	Tamoxifen	220-229	calmodulin 2	Mus musculus	156-166
18953505-0	2009	The effects of calcium channel blocker benidipine and calmodulin antagonist W7 on GDP-binding capacity of brown adipose tissue in mice.	Guanosine Diphosphate	82-85	calmodulin 2	Mus musculus	54-64
19228732-2	2009	We have reported that calmodulin antagonists tamoxifen and trifluoperazine induced apoptosis in cholangiocarcinoma cells.	Tamoxifen	45-54	calmodulin 2	Mus musculus	22-32
19228732-2	2009	We have reported that calmodulin antagonists tamoxifen and trifluoperazine induced apoptosis in cholangiocarcinoma cells.	Trifluoperazine	59-74	calmodulin 2	Mus musculus	22-32
19228732-16	2009	Further, calmodulin-FLIP binding seems to be important in FLIP-mediated resistance to tamoxifen.	Tamoxifen	86-95	calmodulin 2	Mus musculus	9-19
19228732-17	2009	Therefore, the present studies support the concept that tamoxifen may be used as a therapy for cholangiocarcinoma and possibly other malignancies in which the calmodulin targets AKT and c-FLIP play important roles in the tumor pathogenesis.	Tamoxifen	56-65	calmodulin 2	Mus musculus	159-169
18598570-5	2008	Furthermore, we found that the calcium/CaM/CaMKII pathway was important for regulating spindle rotation.	Calcium	31-38	calmodulin 2	Mus musculus	39-42
18635666-7	2008	Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex.	Sepharose	45-52	calmodulin 2	Mus musculus	41-44
18635666-7	2008	Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex.	Sepharose	45-52	calmodulin 2	Mus musculus	111-114
18635666-7	2008	Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex.	Calcium	74-81	calmodulin 2	Mus musculus	41-44
18635666-7	2008	Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex.	Calcium	74-81	calmodulin 2	Mus musculus	111-114
18635666-10	2008	Furthermore, association of Pyk2 and Cam may be required to mediate the effects of calcium on Pyk2 phosphorylation and subsequent activation of ERKs by GnRH.	Calcium	83-90	calmodulin 2	Mus musculus	37-40
19069660-0	2008	[Effect of Atrazine on the content of calcium and expression of calmodulin in splenocytes of mice].	Atrazine	11-19	calmodulin 2	Mus musculus	64-74
19069660-9	2008	CONCLUSION: Atrazine could induced the increase of calcium concentration and the depression of the expression of CaM in splenocytes of mice.	Atrazine	12-20	calmodulin 2	Mus musculus	113-116
18455987-3	2008	Here we show that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM.	Methionine	56-66	calmodulin 2	Mus musculus	85-88
18067926-1	2008	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV159) exhibits selective blocking of Ca(2+)/calmodulin and inhibits Ca(2+) overloading in living organisms.	CV 159	120-125	calmodulin 2	Mus musculus	165-175
18182391-6	2008	Consistently, K-Ras S181D, which mimics phosphorylation of Ser-181 of K-Ras, also completely abolished binding to calmodulin.	Serine	59-62	calmodulin 2	Mus musculus	114-124
17495030-5	2007	PGE(2)-stimulated duodenal HCO(3)(-) secretion was reduced by the cAMP-dependent signaling pathway inhibitors MDL-12330A and KT-5720 by 23% and 20%, respectively; the Ca(2+)-influx inhibitor verapamil by 26%; and the calmodulin antagonist W-13 by 24%; whereas the PI3K inhibitors wortmannin and LY-294002 reduced PGE(2)-stimulated HCO(3)(-) secretion by 51% and 47%, respectively.	Dinoprostone	0-6	calmodulin 2	Mus musculus	217-227
17717281-13	2007	Interestingly, AS160 expressing both calmodulin-binding and Rab-GAP (GTPase-activating protein) domain point mutations (CBD + R/K) fully restored contraction-stimulated glucose uptake.	Glucose	169-176	calmodulin 2	Mus musculus	37-47
17965257-11	2007	Calmodulin is an intracellular receptor for calcium.	Calcium	44-51	calmodulin 2	Mus musculus	0-10
17965257-13	2007	The calmodulin antagonist, W-7, inhibited the ionomycin-induced localization of phosphorylated Creb1 in the nucleus.	Ionomycin	46-55	calmodulin 2	Mus musculus	4-14
18493953-11	2008	These results suggest that a significant amount of calmodulin may be trapped in an inactive state, unable to bind free calcium, and activate downstream signaling pathways.	Calcium	119-126	calmodulin 2	Mus musculus	51-61
18032798-4	2008	Notably, the effect of extracellular calcium on AVP-dependent aquaporin-2 expression was prevented by inhibition of calmodulin.	Calcium	37-44	calmodulin 2	Mus musculus	116-126
18032798-5	2008	In summary, our results show that high concentrations of extracellular calcium attenuate AVP-induced aquaporin-2 expression by activating the CaSR and reducing coupling efficiency between V(2) receptor and adenylate cyclase via a calmodulin-dependent mechanism in cultured cortical collecting duct cells.	Calcium	71-78	calmodulin 2	Mus musculus	230-240
17920764-4	2007	Moreover, GA inhibits vessel growth in matrigel plugs and CAM in vivo and transplanted tumor in mice.	gambogic acid	10-12	calmodulin 2	Mus musculus	58-61
18066127-0	2007	Role of calmodulin and myosin light chain kinase in the activation of carbachol-activated cationic current in murine ileal myocytes.	Carbachol	70-79	calmodulin 2	Mus musculus	8-18
18066127-5	2007	The amplitude of I CCh was reduced by pretreatment either with W-7, trifluoroperazine, W-5, and melittin (CaM inhibitors) or with ML-7 and ML-9 (selective MLCK inhibitors), and the inhibitory effects were reversible.	Carbachol	19-22	calmodulin 2	Mus musculus	106-109
18066127-8	2007	We conclude that CaM and MLCK modulate the activation process of I CCh in murine ileal myocytes and suggest that the classical type transient receptor potential (TRPC) channel 5 might be a candidate for nonselective cationic currents (NSCC) activated by muscarinic stimulation in gastrointestinal smooth muscle cells.	Carbachol	67-70	calmodulin 2	Mus musculus	17-20
18225587-8	2007	Both mRNA expression and protein levels of the immunoglobulin superfamily cell adhesion molecules, Mel-CAM and L1-CAM, were increased in the butyrate-treated cells.	Butyrates	141-149	calmodulin 2	Mus musculus	103-106
18225587-9	2007	CONCLUSION: The HDAC inhibitor butyrate blocked the B16-BL6 melanoma cell invasion of Matrigel, although it increased the expression of Mel-CAM and L1-CAM which are important to the metastatic potential.	Butyrates	31-39	calmodulin 2	Mus musculus	140-143
17349018-1	2007	Melatonin increases neurite formation in N1E-115 cells through microtubule enlargement elicited by calmodulin antagonism and vimentin intermediate filament reorganization caused by protein kinase C (PKC) activation.	Melatonin	0-9	calmodulin 2	Mus musculus	99-109
17202419-7	2007	Ca(2+)-dependent calmodulin/myosin light-chain kinase-mediated contraction was examined by direct Ca(2+) (pCa8-5) stimulation to beta-escin permeabilized aortic strips; the pCa-force curve in Pkd2(+/-) strips was not shifted, thereby indicating that PE induced dosage-response alteration that resulted from Ca(2+)-independent mechanisms.	Escin	129-139	calmodulin 2	Mus musculus	17-27
17202419-7	2007	Ca(2+)-dependent calmodulin/myosin light-chain kinase-mediated contraction was examined by direct Ca(2+) (pCa8-5) stimulation to beta-escin permeabilized aortic strips; the pCa-force curve in Pkd2(+/-) strips was not shifted, thereby indicating that PE induced dosage-response alteration that resulted from Ca(2+)-independent mechanisms.	Phenylephrine	250-252	calmodulin 2	Mus musculus	17-27
16249388-8	2006	The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes.	trifiuoperazine	18-33	calmodulin 2	Mus musculus	4-7
17151196-1	2006	A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation.	Calcium	32-39	calmodulin 2	Mus musculus	45-55
17151196-1	2006	A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation.	Calcium	32-39	calmodulin 2	Mus musculus	57-60
17151196-1	2006	A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation.	Calcium	32-39	calmodulin 2	Mus musculus	149-152
16598065-2	2006	Nav1.8 C-terminus carries a conserved calmodulin-binding isoleucine-glutamine (IQ) motif.	Isoleucine	57-67	calmodulin 2	Mus musculus	38-48
16598065-2	2006	Nav1.8 C-terminus carries a conserved calmodulin-binding isoleucine-glutamine (IQ) motif.	Glutamine	68-77	calmodulin 2	Mus musculus	38-48
16249388-0	2006	Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein.	Hydrogen Peroxide	0-17	calmodulin 2	Mus musculus	133-143
17566278-7	2007	Data presented in this report suggest that calmodulin antagonists prevent capacitation by interfering with multiple regulatory pathways and do so either with or without adverse effects on sperm motility and protein tyrosine phosphorylation of sperm components.	Tyrosine	215-223	calmodulin 2	Mus musculus	43-53
16442703-1	2006	The sarcolemmal calcium pumps (PMCA for plasma membrane calcium/calmodulin dependent ATPase) are a family of 10 transmembrane domain proteins ejecting calcium from the cytosol.	Calcium	16-23	calmodulin 2	Mus musculus	64-74
16249388-8	2006	The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes.	trifiuoperazine	18-33	calmodulin 2	Mus musculus	135-138
16249388-8	2006	The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes.	Hydrogen Peroxide	87-91	calmodulin 2	Mus musculus	4-7
16249388-8	2006	The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes.	Hydrogen Peroxide	87-91	calmodulin 2	Mus musculus	135-138
16249388-9	2006	H2O2/ROSs thus down-regulate IL-12 induction in macrophages by a novel pathway inhibiting c-rel translocation to the nucleus through activation of CaM protein.	Hydrogen Peroxide	0-4	calmodulin 2	Mus musculus	147-150
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	15-17	calmodulin 2	Mus musculus	53-56
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	15-17	calmodulin 2	Mus musculus	93-103
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	15-17	calmodulin 2	Mus musculus	171-174
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	42-44	calmodulin 2	Mus musculus	53-56
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	42-44	calmodulin 2	Mus musculus	93-103
16182446-3	2006	Phosphorylated Ng reduces the affinity of Ng to bind CaM, which may affect the activities of calmodulin-dependent downstream enzymes, such as nitric oxide synthase (NOS), CaM-dependent protein kinase II (CaMKII) and adenylate cyclase (AC).	Nitroglycerin	42-44	calmodulin 2	Mus musculus	171-174
16256941-4	2005	Treatment of CaM-TG mice with the calcineurin inhibitor FK506 (1mg/kg per day) prevented the increase in the heart-to-body weight ratio as well as that in cardiomyocyte width.	Tacrolimus	56-61	calmodulin 2	Mus musculus	13-16
16379381-1	2005	A surface plasmon resonance (SPR) biosensor for the quantification of a neuropeptide substance P (SP) is described based on an inhibition assay using Au colloid-modified calmodulin (Au-CaM) and a target peptide melittin immobilized on carboxymethylated dextran.	Gold	150-152	calmodulin 2	Mus musculus	170-180
16379381-2	2005	The modification of CaM with streptavidin Au colloids was achieved in a sample solution by the amine coupling method.	Amines	95-100	calmodulin 2	Mus musculus	20-23
16256941-5	2005	FK506 also inhibited the induction of fetal-type cardiac gene expression in CaM-TG mice.	Tacrolimus	0-5	calmodulin 2	Mus musculus	76-79
16183639-10	2005	Thus the mTOR-S6K pathway in neurons, a critical component of the late phase of LTP, is activated by glutamatergic stimulation in a calcium/calmodulin-dependent fashion through a calcium pool controlled by postsynaptic voltage-dependent calcium channels, whereas sustained stimulation of extrasynaptic glutamate receptors is inhibitory.	Calcium	132-139	calmodulin 2	Mus musculus	140-150
16358785-0	2005	[The calmodulin inhibitor R24571 induces a short-term Ca2+ entry and a pulse-like secretion of ATP in Ehrlich ascites tumor cells].	calmidazolium	26-32	calmodulin 2	Mus musculus	5-15
16358785-0	2005	[The calmodulin inhibitor R24571 induces a short-term Ca2+ entry and a pulse-like secretion of ATP in Ehrlich ascites tumor cells].	Adenosine Triphosphate	95-98	calmodulin 2	Mus musculus	5-15
16358785-1	2005	The properties of the Ca2+ channel induced by a calmodulin inhibitor in Ehrlich ascites tumor cells were investigated using fluorescent indicators Indo-1 and chlortetracycline.	indo-1	147-153	calmodulin 2	Mus musculus	48-58
16358785-1	2005	The properties of the Ca2+ channel induced by a calmodulin inhibitor in Ehrlich ascites tumor cells were investigated using fluorescent indicators Indo-1 and chlortetracycline.	Chlortetracycline	158-175	calmodulin 2	Mus musculus	48-58
16358785-2	2005	The inhibitor of calmodulin calmidazolium (R24571) in concentrations of 1-2 microM induces a short-term Ca2+ entry and a pulse-like ATP secretion.	calmidazolium	28-41	calmodulin 2	Mus musculus	17-27
16358785-2	2005	The inhibitor of calmodulin calmidazolium (R24571) in concentrations of 1-2 microM induces a short-term Ca2+ entry and a pulse-like ATP secretion.	calmidazolium	43-49	calmodulin 2	Mus musculus	17-27
16358785-2	2005	The inhibitor of calmodulin calmidazolium (R24571) in concentrations of 1-2 microM induces a short-term Ca2+ entry and a pulse-like ATP secretion.	Adenosine Triphosphate	132-135	calmodulin 2	Mus musculus	17-27
16358785-10	2005	Using chlortetracycline fluorescence, we have shown in model experiments on calmodulin solution that Ca2+ induces cooperatively a conformational transition of calmodulin with the exposure of a hydrophobic chlortetracycline-Ca(2+)-binding site.	Chlortetracycline	6-23	calmodulin 2	Mus musculus	76-86
16358785-10	2005	Using chlortetracycline fluorescence, we have shown in model experiments on calmodulin solution that Ca2+ induces cooperatively a conformational transition of calmodulin with the exposure of a hydrophobic chlortetracycline-Ca(2+)-binding site.	Chlortetracycline	6-23	calmodulin 2	Mus musculus	159-169
16358785-10	2005	Using chlortetracycline fluorescence, we have shown in model experiments on calmodulin solution that Ca2+ induces cooperatively a conformational transition of calmodulin with the exposure of a hydrophobic chlortetracycline-Ca(2+)-binding site.	Chlortetracycline	205-222	calmodulin 2	Mus musculus	76-86
16358785-10	2005	Using chlortetracycline fluorescence, we have shown in model experiments on calmodulin solution that Ca2+ induces cooperatively a conformational transition of calmodulin with the exposure of a hydrophobic chlortetracycline-Ca(2+)-binding site.	Chlortetracycline	205-222	calmodulin 2	Mus musculus	159-169
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Water	105-110	calmodulin 2	Mus musculus	35-38
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Water	105-110	calmodulin 2	Mus musculus	175-185
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Chlortetracycline	207-224	calmodulin 2	Mus musculus	35-38
16358785-11	2005	The interaction of R24571 with the CaM-Ca2+ complex results in quenching of fluorescence to its level in water, which is interpreted as the elimination of the availability of calmodulin hydrophobic site for chlortetracycline-Ca+.	Chlortetracycline	207-224	calmodulin 2	Mus musculus	175-185
16358785-12	2005	Nordihydroguaretic acid, quercetin, and dihydroquercetin, but not suramin, also interact with calmodulin, but this does not result in the complete closing of its hydrophobic site.	Masoprocol	0-23	calmodulin 2	Mus musculus	94-104
16358785-12	2005	Nordihydroguaretic acid, quercetin, and dihydroquercetin, but not suramin, also interact with calmodulin, but this does not result in the complete closing of its hydrophobic site.	Quercetin	25-34	calmodulin 2	Mus musculus	94-104
16358785-12	2005	Nordihydroguaretic acid, quercetin, and dihydroquercetin, but not suramin, also interact with calmodulin, but this does not result in the complete closing of its hydrophobic site.	taxifolin	40-56	calmodulin 2	Mus musculus	94-104
15845548-8	2005	Thus, our results demonstrate that G protein-coupled receptor activation induces rapid FAK phosphorylation at Ser-843 through Ca2+, calmodulin, and CaMKII.	Serine	110-113	calmodulin 2	Mus musculus	132-142
15901640-7	2005	In vitro translation of the corresponding Pde1a_v7 cDNA produced a 52-kDa polypeptide having cyclic nucleotide hydrolytic activity, which was stimulated threefold by calcium-bound calmodulin.	Nucleotides, Cyclic	93-110	calmodulin 2	Mus musculus	180-190
15901640-7	2005	In vitro translation of the corresponding Pde1a_v7 cDNA produced a 52-kDa polypeptide having cyclic nucleotide hydrolytic activity, which was stimulated threefold by calcium-bound calmodulin.	Calcium	166-173	calmodulin 2	Mus musculus	180-190
15890671-7	2005	Enrichment of Cam-interacting proteins using a Cam agarose column revealed that c-Raf kinase forms a complex with Cam.	Sepharose	51-58	calmodulin 2	Mus musculus	14-17
15890671-7	2005	Enrichment of Cam-interacting proteins using a Cam agarose column revealed that c-Raf kinase forms a complex with Cam.	Sepharose	51-58	calmodulin 2	Mus musculus	47-50
15890671-7	2005	Enrichment of Cam-interacting proteins using a Cam agarose column revealed that c-Raf kinase forms a complex with Cam.	Sepharose	51-58	calmodulin 2	Mus musculus	47-50
15965236-0	2005	Fas binding to calmodulin regulates apoptosis in osteoclasts.	ammonium ferrous sulfate	0-3	calmodulin 2	Mus musculus	15-25
15965236-9	2005	In osteoclasts, calmodulin also binds Fas.	ammonium ferrous sulfate	38-41	calmodulin 2	Mus musculus	16-26
15965236-10	2005	When osteoclasts are treated with 10 microm trifluoperazine, the binding between Fas and calmodulin is dramatically decreased at 15 min and gradually recovers by 60 min.	Trifluoperazine	44-59	calmodulin 2	Mus musculus	89-99
15970592-9	2005	Finally, we showed that CaM decreases 5-HT2A receptor-mediated [35S]GTPgammaS binding to NIH-3T3 cell membranes, supporting a possible role for CaM in regulating receptor-G protein coupling.	Sulfur-35	64-67	calmodulin 2	Mus musculus	24-27
15970592-9	2005	Finally, we showed that CaM decreases 5-HT2A receptor-mediated [35S]GTPgammaS binding to NIH-3T3 cell membranes, supporting a possible role for CaM in regulating receptor-G protein coupling.	Guanosine 5'-O-(3-Thiotriphosphate)	68-77	calmodulin 2	Mus musculus	24-27
15611992-2	2005	Like calmodulin, NCS-1 is a member of a family of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformational changes in the protein.	Calcium	50-57	calmodulin 2	Mus musculus	5-15
15691827-7	2005	As in these reports, inhibition of calmodulin led to rapid GPV shedding from the platelet surface, a process that was again blocked by GM6001 or ADAM17 inhibitors and that was absent in ADAM17(DeltaZn/DeltaZn) mice.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	135-141	calmodulin 2	Mus musculus	35-45
15590632-5	2005	Inhibition of CaMKII by the calmodulin antagonist trifluoperazine or the CaMKII antagonist KN93 reduces alkaline phosphatase activity and mineralization, as well as causes 85 and 56% decreases in alkaline phosphatase and osteocalcin gene expression, respectively.	Trifluoperazine	50-65	calmodulin 2	Mus musculus	28-38
15611992-2	2005	Like calmodulin, NCS-1 is a member of a family of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformational changes in the protein.	Calcium	115-122	calmodulin 2	Mus musculus	5-15
12960067-4	2003	Calmodulin antagonists, trifluoperazine (TFP), W7, and tamoxifen, dose-dependently inhibited osteoclast formation, which occurred only in the last 24 h of a 4-d osteoclastogenesis culture using mouse bone marrow macrophages.	Trifluoperazine	24-39	calmodulin 2	Mus musculus	0-10
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Sepharose	62-69	calmodulin 2	Mus musculus	51-61
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Sepharose	62-69	calmodulin 2	Mus musculus	177-187
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Calcium Chloride	95-102	calmodulin 2	Mus musculus	51-61
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Calcium Chloride	95-102	calmodulin 2	Mus musculus	177-187
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Egtazic Acid	106-110	calmodulin 2	Mus musculus	51-61
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Egtazic Acid	106-110	calmodulin 2	Mus musculus	177-187
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Calcium	112-119	calmodulin 2	Mus musculus	51-61
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Calcium	112-119	calmodulin 2	Mus musculus	177-187
14594800-4	2004	Here, we demonstrate that CaM binds to Fas directly and identify the CaM-binding site on the cytoplasmic death domain (DD) of Fas.	ammonium ferrous sulfate	39-42	calmodulin 2	Mus musculus	26-29
14594800-4	2004	Here, we demonstrate that CaM binds to Fas directly and identify the CaM-binding site on the cytoplasmic death domain (DD) of Fas.	ammonium ferrous sulfate	126-129	calmodulin 2	Mus musculus	26-29
14594800-4	2004	Here, we demonstrate that CaM binds to Fas directly and identify the CaM-binding site on the cytoplasmic death domain (DD) of Fas.	ammonium ferrous sulfate	126-129	calmodulin 2	Mus musculus	69-72
14594800-5	2004	Fas binds to CaM-Sepharose and is co-immunoprecipitated with CaM.	Sepharose	17-26	calmodulin 2	Mus musculus	13-16
14594800-7	2004	The interaction between Fas and CaM is Ca(2+)-dependent.	ammonium ferrous sulfate	24-27	calmodulin 2	Mus musculus	32-35
14594800-10	2004	A valine 254 to asparagine mutation in this region, which is analogous to the identified mutant allele of Fas in lpr mice that have a deficiency in Fas-mediated apoptosis, showed reduced CaM binding.	ammonium ferrous sulfate	106-109	calmodulin 2	Mus musculus	187-190
14594800-10	2004	A valine 254 to asparagine mutation in this region, which is analogous to the identified mutant allele of Fas in lpr mice that have a deficiency in Fas-mediated apoptosis, showed reduced CaM binding.	ammonium ferrous sulfate	148-151	calmodulin 2	Mus musculus	187-190
14594800-11	2004	Computer modeling of the interaction between CaM and helix 2 of the Fas DD predicted that amino acids, which are important for Fas-CaM binding, and point mutations of these amino acids caused reduced Fas-CaM binding.	ammonium ferrous sulfate	68-71	calmodulin 2	Mus musculus	45-48
14594800-11	2004	Computer modeling of the interaction between CaM and helix 2 of the Fas DD predicted that amino acids, which are important for Fas-CaM binding, and point mutations of these amino acids caused reduced Fas-CaM binding.	ammonium ferrous sulfate	68-71	calmodulin 2	Mus musculus	131-134
14594800-11	2004	Computer modeling of the interaction between CaM and helix 2 of the Fas DD predicted that amino acids, which are important for Fas-CaM binding, and point mutations of these amino acids caused reduced Fas-CaM binding.	ammonium ferrous sulfate	68-71	calmodulin 2	Mus musculus	131-134
14594800-12	2004	The interaction between Fas and CaM is increased approximately 2-fold early upon Fas activation (at 30 min) and is decreased to approximately 50% of control at 2 h. These findings suggest a novel function of CaM in Fas-mediated apoptosis.	ammonium ferrous sulfate	24-27	calmodulin 2	Mus musculus	32-35
14594800-12	2004	The interaction between Fas and CaM is increased approximately 2-fold early upon Fas activation (at 30 min) and is decreased to approximately 50% of control at 2 h. These findings suggest a novel function of CaM in Fas-mediated apoptosis.	ammonium ferrous sulfate	24-27	calmodulin 2	Mus musculus	208-211
14594800-12	2004	The interaction between Fas and CaM is increased approximately 2-fold early upon Fas activation (at 30 min) and is decreased to approximately 50% of control at 2 h. These findings suggest a novel function of CaM in Fas-mediated apoptosis.	ammonium ferrous sulfate	81-84	calmodulin 2	Mus musculus	32-35
14594800-12	2004	The interaction between Fas and CaM is increased approximately 2-fold early upon Fas activation (at 30 min) and is decreased to approximately 50% of control at 2 h. These findings suggest a novel function of CaM in Fas-mediated apoptosis.	ammonium ferrous sulfate	81-84	calmodulin 2	Mus musculus	208-211
15109989-11	2004	Taking the data from calcium chelation and CaM inhibition together, our results suggest that the dynamic distribution patterns of calcium and activated CaM are crucial for oocyte maturation.	Calcium	21-28	calmodulin 2	Mus musculus	152-155
15109989-11	2004	Taking the data from calcium chelation and CaM inhibition together, our results suggest that the dynamic distribution patterns of calcium and activated CaM are crucial for oocyte maturation.	Calcium	130-137	calmodulin 2	Mus musculus	43-46
14597235-4	2003	Blockade of calmodulin affects the GTP-loading of Ras and Rap1 and prevents the MAPK response.	Guanosine Triphosphate	35-38	calmodulin 2	Mus musculus	12-22
15466369-7	2004	After enteral administration of [13C]EFA, arachidonic acid (AA) and docosahexaenoic acid (DHA) were equally 13C-enriched in cftr-/-CAM and cftr+/+CAM mice, indicating similar EFA elongation/desaturation rates.	Docosahexaenoic Acids	90-93	calmodulin 2	Mus musculus	131-134
15466369-10	2004	We conclude that cftr-/-CAM mice adequately absorb and metabolize EFA, indicating that CFTR dysfunction does not impair LCPUFA synthesis.	Fatty Acids, Essential	66-69	calmodulin 2	Mus musculus	24-27
15098941-5	2004	More importantly, we demonstrate that the calmodulin-mediated inhibition of phosphorylation was restored by preincubating the cortical neurons with KN-62, a CaM kinase inhibitor.	KN 62	148-153	calmodulin 2	Mus musculus	42-52
12960067-4	2003	Calmodulin antagonists, trifluoperazine (TFP), W7, and tamoxifen, dose-dependently inhibited osteoclast formation, which occurred only in the last 24 h of a 4-d osteoclastogenesis culture using mouse bone marrow macrophages.	Tamoxifen	55-64	calmodulin 2	Mus musculus	0-10
12881478-6	2003	These effects of Hcy were primarily mediated by reactive oxygen species (ROS) through NAD(P)H oxidase, because Hcy could upregulate the production of ROS and the inhibitors of protein kinase C, calmodulin, free radical scavengers, or NAD(P)H oxidase abolished Hcy-induced ROS production and MCP-1 and IL-8 secretion in these cells.	Reactive Oxygen Species	73-76	calmodulin 2	Mus musculus	194-204
12950461-0	2003	Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus.	N-Methylaspartate	17-21	calmodulin 2	Mus musculus	112-122
12881478-6	2003	These effects of Hcy were primarily mediated by reactive oxygen species (ROS) through NAD(P)H oxidase, because Hcy could upregulate the production of ROS and the inhibitors of protein kinase C, calmodulin, free radical scavengers, or NAD(P)H oxidase abolished Hcy-induced ROS production and MCP-1 and IL-8 secretion in these cells.	Homocysteine	17-20	calmodulin 2	Mus musculus	194-204
12881478-6	2003	These effects of Hcy were primarily mediated by reactive oxygen species (ROS) through NAD(P)H oxidase, because Hcy could upregulate the production of ROS and the inhibitors of protein kinase C, calmodulin, free radical scavengers, or NAD(P)H oxidase abolished Hcy-induced ROS production and MCP-1 and IL-8 secretion in these cells.	Homocysteine	111-114	calmodulin 2	Mus musculus	194-204
12881478-6	2003	These effects of Hcy were primarily mediated by reactive oxygen species (ROS) through NAD(P)H oxidase, because Hcy could upregulate the production of ROS and the inhibitors of protein kinase C, calmodulin, free radical scavengers, or NAD(P)H oxidase abolished Hcy-induced ROS production and MCP-1 and IL-8 secretion in these cells.	Homocysteine	111-114	calmodulin 2	Mus musculus	194-204
12668727-0	2003	Calmodulin antagonists differentially affect capacitation-associated protein tyrosine phosphorylation of mouse sperm components.	Tyrosine	77-85	calmodulin 2	Mus musculus	0-10
12865156-2	2003	A reduction in serum calcium levels decreases calcium/calmodulin-dependent-dopamine synthesis in the brain and subsequently increases susceptibility to epileptic convulsions and induces abnormal behavior in EL mice.	Calcium	21-28	calmodulin 2	Mus musculus	54-64
12865156-2	2003	A reduction in serum calcium levels decreases calcium/calmodulin-dependent-dopamine synthesis in the brain and subsequently increases susceptibility to epileptic convulsions and induces abnormal behavior in EL mice.	Dopamine	75-83	calmodulin 2	Mus musculus	54-64
12668727-7	2003	Fourth, by contrast, three CaM antagonists (W7, ophiobolin A and calmidazolium) significantly inhibited protein tyrosine phosphorylation of sperm components (42, 56, 66, 82 and 95 kDa) and adversely affected their motility without altering viability as assessed by propidium iodine staining.	ophiobolin A	48-60	calmodulin 2	Mus musculus	27-30
12668727-7	2003	Fourth, by contrast, three CaM antagonists (W7, ophiobolin A and calmidazolium) significantly inhibited protein tyrosine phosphorylation of sperm components (42, 56, 66, 82 and 95 kDa) and adversely affected their motility without altering viability as assessed by propidium iodine staining.	calmidazolium	65-78	calmodulin 2	Mus musculus	27-30
12668727-2	2003	Our group recently used a pharmacological approach to demonstrate that calmodulin (CaM), a 17 kDa calcium sensor protein, has a role in sperm capacitation.	Calcium	98-105	calmodulin 2	Mus musculus	71-81
12668727-7	2003	Fourth, by contrast, three CaM antagonists (W7, ophiobolin A and calmidazolium) significantly inhibited protein tyrosine phosphorylation of sperm components (42, 56, 66, 82 and 95 kDa) and adversely affected their motility without altering viability as assessed by propidium iodine staining.	Tyrosine	112-120	calmodulin 2	Mus musculus	27-30
12668727-2	2003	Our group recently used a pharmacological approach to demonstrate that calmodulin (CaM), a 17 kDa calcium sensor protein, has a role in sperm capacitation.	Calcium	98-105	calmodulin 2	Mus musculus	83-86
12668727-7	2003	Fourth, by contrast, three CaM antagonists (W7, ophiobolin A and calmidazolium) significantly inhibited protein tyrosine phosphorylation of sperm components (42, 56, 66, 82 and 95 kDa) and adversely affected their motility without altering viability as assessed by propidium iodine staining.	Propidium	265-281	calmodulin 2	Mus musculus	27-30
12668727-3	2003	In the present study, we have used several CaM antagonists in an attempt to characterize further the role of CaM in capacitation-associated protein tyrosine phosphorylation of sperm components.	Tyrosine	148-156	calmodulin 2	Mus musculus	109-112
12668727-8	2003	Finally, inclusion of purified CaM in the capacitation medium significantly increased tyrosine phosphorylation of 82 kDa and 95 kDa components.	Tyrosine	86-94	calmodulin 2	Mus musculus	31-34
12668727-9	2003	Combined, these data suggest that CaM antagonists prevent capacitation by interfering with multiple regulatory pathways, and do so either with or without adverse effects on sperm motility and protein tyrosine phosphorylation.	Tyrosine	200-208	calmodulin 2	Mus musculus	34-37
12734700-2	2003	The calcium-sensitive global motion of either calmodulin domain can be independently monitored in domain-specific interactions of either apo- or Ca(4).calmodulin with IQ3 or IQ4 peptides.	Calcium	4-11	calmodulin 2	Mus musculus	46-56
12734700-4	2003	The 1:1 complex of Ca(4).calmodulin with IQ34 behaves as a compact globular species.	fosbretabulin	19-24	calmodulin 2	Mus musculus	25-35
12734700-0	2003	Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V. Single cysteine mutants of calmodulin, Cam(S38C) and Cam(N111C), have been specifically labelled with Alexa488 maleimide to study the effects of calcium on the structural dynamics of calmodulin complexed with IQ3, IQ4 and IQ34 target peptide motifs of mouse unconventional myosin-V.	Cysteine	139-147	calmodulin 2	Mus musculus	83-93
12734700-5	2003	The results demonstrate novel dynamic aspects of calmodulin-IQ interactions relating to the calcium regulation of motility of unconventional myosin.	Calcium	92-99	calmodulin 2	Mus musculus	49-59
12734700-0	2003	Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V. Single cysteine mutants of calmodulin, Cam(S38C) and Cam(N111C), have been specifically labelled with Alexa488 maleimide to study the effects of calcium on the structural dynamics of calmodulin complexed with IQ3, IQ4 and IQ34 target peptide motifs of mouse unconventional myosin-V.	alexa488 maleimide	234-252	calmodulin 2	Mus musculus	83-93
12638236-0	2003	D-galactosamine induced hepatocyte apoptosis is inhibited in vivo and in cell culture by a calcium calmodulin antagonist, chlorpromazine, and a calcium channel blocker, verapamil.	Galactosamine	0-15	calmodulin 2	Mus musculus	99-109
12734700-0	2003	Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V. Single cysteine mutants of calmodulin, Cam(S38C) and Cam(N111C), have been specifically labelled with Alexa488 maleimide to study the effects of calcium on the structural dynamics of calmodulin complexed with IQ3, IQ4 and IQ34 target peptide motifs of mouse unconventional myosin-V.	Calcium	277-284	calmodulin 2	Mus musculus	83-93
12539202-4	2003	Similarly, the calmodulin antagonist W-7 (N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide) inhibited the augmenting effect of clozapine on NMDA- and electrically evoked responses in the pyramidal cells.	w-7 (n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide	37-92	calmodulin 2	Mus musculus	15-25
12539202-4	2003	Similarly, the calmodulin antagonist W-7 (N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide) inhibited the augmenting effect of clozapine on NMDA- and electrically evoked responses in the pyramidal cells.	Clozapine	129-138	calmodulin 2	Mus musculus	15-25
12539202-4	2003	Similarly, the calmodulin antagonist W-7 (N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide) inhibited the augmenting effect of clozapine on NMDA- and electrically evoked responses in the pyramidal cells.	N-Methylaspartate	142-146	calmodulin 2	Mus musculus	15-25
15346980-10	2002	Our results further confirmed that the resumption of meiosis maturation was promoted in a calcium/CaM depended pathway.	Calcium	90-97	calmodulin 2	Mus musculus	98-101
12454732-2	2002	Inhibition of Ca(2+)-calmodulin-dependent protein kinase (CaM kinase II) with the calmodulin antagonist N-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide (W-13) did not antagonise the effect of NAS-181 alone, but counteracted that evoked by the combined treatment with NAS-181 and WAY-100,635.	n-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide	104-153	calmodulin 2	Mus musculus	21-31
12454732-2	2002	Inhibition of Ca(2+)-calmodulin-dependent protein kinase (CaM kinase II) with the calmodulin antagonist N-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide (W-13) did not antagonise the effect of NAS-181 alone, but counteracted that evoked by the combined treatment with NAS-181 and WAY-100,635.	n-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide	104-153	calmodulin 2	Mus musculus	82-92
12454732-2	2002	Inhibition of Ca(2+)-calmodulin-dependent protein kinase (CaM kinase II) with the calmodulin antagonist N-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide (W-13) did not antagonise the effect of NAS-181 alone, but counteracted that evoked by the combined treatment with NAS-181 and WAY-100,635.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	155-159	calmodulin 2	Mus musculus	21-31
12454732-2	2002	Inhibition of Ca(2+)-calmodulin-dependent protein kinase (CaM kinase II) with the calmodulin antagonist N-(4-aminobutyl)-5-chloro-2-naphtalenesulfonamide (W-13) did not antagonise the effect of NAS-181 alone, but counteracted that evoked by the combined treatment with NAS-181 and WAY-100,635.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	155-159	calmodulin 2	Mus musculus	82-92
12151388-5	2002	Hence, anti-calmodulin drugs (such as W13, trifluoroperazine, or W7) are able to induce Ras/ERK pathway activation under low levels of growth factors.	Trifluoperazine	43-60	calmodulin 2	Mus musculus	12-22
12151388-12	2002	Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited.	Tetradecanoylphorbol Acetate	101-104	calmodulin 2	Mus musculus	60-70
12151388-12	2002	Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited.	Tetradecanoylphorbol Acetate	101-104	calmodulin 2	Mus musculus	110-120
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	calmodulin 2	Mus musculus	86-96
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	calmodulin 2	Mus musculus	114-124
12133551-18	2002	CONCLUSIONS: The CaM antagonist, EBB, has a strong anti-hepatoma effect and enhances the effect of 5-FU, induces hepatoma cell to apoptosis, promotes the P53 protein expression and decreases the amount of CaM in the cytoplasm.	Fluorouracil	99-103	calmodulin 2	Mus musculus	17-20
12242083-2	2002	We investigated here the effect of clotrimazole (1-(alpha-2-chlorotrityl)imidazole), the antifungal azole derivative, which was recently recognized as calmodulin antagonist, on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells.	Clotrimazole	35-47	calmodulin 2	Mus musculus	151-161
12242083-2	2002	We investigated here the effect of clotrimazole (1-(alpha-2-chlorotrityl)imidazole), the antifungal azole derivative, which was recently recognized as calmodulin antagonist, on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells.	1-(alpha-2-chlorotrityl)imidazole	49-82	calmodulin 2	Mus musculus	151-161
12242083-2	2002	We investigated here the effect of clotrimazole (1-(alpha-2-chlorotrityl)imidazole), the antifungal azole derivative, which was recently recognized as calmodulin antagonist, on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells.	Azoles	42-47	calmodulin 2	Mus musculus	151-161
12242083-2	2002	We investigated here the effect of clotrimazole (1-(alpha-2-chlorotrityl)imidazole), the antifungal azole derivative, which was recently recognized as calmodulin antagonist, on the levels of glucose 1,6-bisphosphate and fructose 1,6-bisphosphate, the two stimulatory signal molecules of glycolysis, and on ATP content and cell viability in LL/2 Lewis lung carcinoma cells and CT-26 colon adenocarcinoma cells.	glucose-1,6-bisphosphate	191-215	calmodulin 2	Mus musculus	151-161
12242083-5	2002	Since cell proliferation was also reported to be inhibited by calmodulin antagonists, this substance is most promising agent in treatment of cancer by inhibiting both cell proliferation and the glycolytic supply of ATP required for cancer cell growth.	Adenosine Triphosphate	215-218	calmodulin 2	Mus musculus	62-72
12115528-3	2002	Fas-low cells are resistant to apoptosis induced by Fas antibody and the calmodulin antagonists tamoxifen and trifluoperazine and are tumorigenic in nude mice (Pan et al., Am J Pathol 1999;155:193-203).	Tamoxifen	96-105	calmodulin 2	Mus musculus	73-83
12007836-7	2002	Blocking calmodulin by W-7 revealed a similar partial inhibition of the stimulatory effect of DALN.	W 7	23-26	calmodulin 2	Mus musculus	9-19
12007836-8	2002	Hence, we suggest a cannabinoid-specific, PTX-insensitive, stimulatory effect on L-type voltage-dependent calcium channels, which is mediated by PKA and modulated by PKC and calmodulin.	Cannabinoids	20-31	calmodulin 2	Mus musculus	174-184
12133551-1	2002	OBJECTIVE: To evaluate the anti-hepatoma effect of Calmodulin antagonist 0 - 4-ethoxyl-butyl-Berbamine (EBB), one of the berbamine derivatives.	0 - 4-ethoxyl-butyl-berbamine	73-102	calmodulin 2	Mus musculus	51-61
12133551-1	2002	OBJECTIVE: To evaluate the anti-hepatoma effect of Calmodulin antagonist 0 - 4-ethoxyl-butyl-Berbamine (EBB), one of the berbamine derivatives.	O-(4-ethoxybutyl)berbamine	104-107	calmodulin 2	Mus musculus	51-61
12133551-1	2002	OBJECTIVE: To evaluate the anti-hepatoma effect of Calmodulin antagonist 0 - 4-ethoxyl-butyl-Berbamine (EBB), one of the berbamine derivatives.	berbamine	121-130	calmodulin 2	Mus musculus	51-61
12133551-16	2002	As a calmodulin antagonist, EBB decreases amount of the CaM in hepatoma cells and blocked the hepatoma cell proliferation cycle at the G(2)M phase.	O-(4-ethoxybutyl)berbamine	28-31	calmodulin 2	Mus musculus	5-15
12133551-16	2002	As a calmodulin antagonist, EBB decreases amount of the CaM in hepatoma cells and blocked the hepatoma cell proliferation cycle at the G(2)M phase.	O-(4-ethoxybutyl)berbamine	28-31	calmodulin 2	Mus musculus	56-59
12133551-18	2002	CONCLUSIONS: The CaM antagonist, EBB, has a strong anti-hepatoma effect and enhances the effect of 5-FU, induces hepatoma cell to apoptosis, promotes the P53 protein expression and decreases the amount of CaM in the cytoplasm.	O-(4-ethoxybutyl)berbamine	33-36	calmodulin 2	Mus musculus	17-20
12133551-18	2002	CONCLUSIONS: The CaM antagonist, EBB, has a strong anti-hepatoma effect and enhances the effect of 5-FU, induces hepatoma cell to apoptosis, promotes the P53 protein expression and decreases the amount of CaM in the cytoplasm.	O-(4-ethoxybutyl)berbamine	33-36	calmodulin 2	Mus musculus	205-208
12234092-4	2002	Using fluorescence microscopy, it was shown that MBP and CaM interacted in the presence of Ca2+ under a variety of conditions, including high urea and salt concentrations, indicating that the interaction was specific and not merely electrostatic in nature.	Urea	142-146	calmodulin 2	Mus musculus	57-60
12234092-4	2002	Using fluorescence microscopy, it was shown that MBP and CaM interacted in the presence of Ca2+ under a variety of conditions, including high urea and salt concentrations, indicating that the interaction was specific and not merely electrostatic in nature.	Salts	151-155	calmodulin 2	Mus musculus	57-60
12234092-7	2002	The dissociation constants for formation of a 1:1 MBP-Ca(2+)-CaM complex were determined to be 2.1 +/- 0.1 and 2.0 +/- 0.2 microM for bMBP/C1 and rmMBP, respectively.	bmbp	134-138	calmodulin 2	Mus musculus	61-64
12234092-7	2002	The dissociation constants for formation of a 1:1 MBP-Ca(2+)-CaM complex were determined to be 2.1 +/- 0.1 and 2.0 +/- 0.2 microM for bMBP/C1 and rmMBP, respectively.	rmmbp	146-151	calmodulin 2	Mus musculus	61-64
12234092-8	2002	Fluorescence spectroscopy using cathepsin D digestion fragments indicated also that the carboxyl-terminal region of each protein interacted with Ca(2+)-CaM, with dissociation constants of 1.8 +/- 0.2 and 2.8 +/- 0.9 microM for the bMBP/C1 and rmMBP fragments, respectively.	bmbp	231-235	calmodulin 2	Mus musculus	152-155
12234092-8	2002	Fluorescence spectroscopy using cathepsin D digestion fragments indicated also that the carboxyl-terminal region of each protein interacted with Ca(2+)-CaM, with dissociation constants of 1.8 +/- 0.2 and 2.8 +/- 0.9 microM for the bMBP/C1 and rmMBP fragments, respectively.	rmmbp	243-248	calmodulin 2	Mus musculus	152-155
11590224-6	2001	Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects.	Quin2-acetoxymethyl ester	0-9	calmodulin 2	Mus musculus	88-98
11679602-7	2001	The use of specific metabolic inhibitors indicated that, with capacitive coupling, signal transduction was by means of influx of Ca(2+) through voltage-gated calcium channels leading to an increase in cytosolic Ca(2+) (blocked by verapamil), cytoskeletal calmodulin (blocked by W-7), and prostaglandin E2 (blocked by indomethacin).	Verapamil	230-239	calmodulin 2	Mus musculus	255-265
11590224-6	2001	Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects.	W 7	14-17	calmodulin 2	Mus musculus	88-98
11590224-6	2001	Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects.	Cyclic AMP	49-53	calmodulin 2	Mus musculus	88-98
11517253-7	2001	Evidence supporting the participation of the CaM kinase pathway on K(+)-induced increased coupling was obtained in experiments showing that calmidazolium and KN-93 totally prevented the increase in dye and electrical coupling induced by high K(+) solutions.	calmidazolium	140-153	calmodulin 2	Mus musculus	45-48
11517253-7	2001	Evidence supporting the participation of the CaM kinase pathway on K(+)-induced increased coupling was obtained in experiments showing that calmidazolium and KN-93 totally prevented the increase in dye and electrical coupling induced by high K(+) solutions.	KN 93	158-163	calmodulin 2	Mus musculus	45-48
12580100-7	2001	Specific calmodulin antagonist W-7 was found to significantly inhibit the elevation of calmodulin and CaMK II activity which resulted from DPDPE long-term treatment, and CaMK II inhibitor KN-62 also inhibited elevation of CaMK II activity by DPDPE long-term treatment.	W 7	31-34	calmodulin 2	Mus musculus	9-19
12580100-8	2001	When naloxone was added to NG108-15 cells which were long-term treated by DPDPE, calmodulin and CaMK II activity increased, indicating that naloxone withdrawal can increase Ca2+/CaMK II pathway activity.	Naloxone	5-13	calmodulin 2	Mus musculus	81-91
12580100-7	2001	Specific calmodulin antagonist W-7 was found to significantly inhibit the elevation of calmodulin and CaMK II activity which resulted from DPDPE long-term treatment, and CaMK II inhibitor KN-62 also inhibited elevation of CaMK II activity by DPDPE long-term treatment.	W 7	31-34	calmodulin 2	Mus musculus	87-97
12580100-8	2001	When naloxone was added to NG108-15 cells which were long-term treated by DPDPE, calmodulin and CaMK II activity increased, indicating that naloxone withdrawal can increase Ca2+/CaMK II pathway activity.	Naloxone	140-148	calmodulin 2	Mus musculus	81-91
11389972-0	2001	Nitric oxide regulates actin reorganization through cGMP and Ca(2+)/calmodulin in RAW 264.7 cells.	Nitric Oxide	0-12	calmodulin 2	Mus musculus	68-78
11389972-7	2001	Preincubation with the calmodulin antagonist W-7 almost completely blocked the NO-induced TIF-actin increase and morphological change.	W 7	45-48	calmodulin 2	Mus musculus	23-33
11408087-1	2001	Previous reports have revealed that calmodulin antagonism by melatonin is followed by microtubule enlargements and neurite outgrowths in neuroblastoma N1E-115 cells.	Melatonin	61-70	calmodulin 2	Mus musculus	36-46
11278760-6	2001	We propose that Jak2 is a new indirect regulator of NHE-1 activity, which modulates the activity of NHE-1 by increasing the tyrosine phosphorylation of CaM and most likely by increasing the binding of CaM to NHE-1.	Tyrosine	124-132	calmodulin 2	Mus musculus	152-155
11429650-0	2001	Involvement of calmodulin in glucagon-like peptide 1(7-36) amide-induced inhibition of the ATP-sensitive K+ channel in mouse pancreatic beta-cells.	Amides	59-64	calmodulin 2	Mus musculus	15-25
11429650-1	2001	The present investigation was designed to examine whether calmodulin is involved in the inhibition of the ATP-sensitive K+ (K(ATP)) channel by glucagon-like peptide 1(7-36) amide (GLP-1) in mouse pancreatic beta-cells.	Adenosine Triphosphate	106-109	calmodulin 2	Mus musculus	58-68
11429650-1	2001	The present investigation was designed to examine whether calmodulin is involved in the inhibition of the ATP-sensitive K+ (K(ATP)) channel by glucagon-like peptide 1(7-36) amide (GLP-1) in mouse pancreatic beta-cells.	Adenosine Triphosphate	126-129	calmodulin 2	Mus musculus	58-68
11429650-1	2001	The present investigation was designed to examine whether calmodulin is involved in the inhibition of the ATP-sensitive K+ (K(ATP)) channel by glucagon-like peptide 1(7-36) amide (GLP-1) in mouse pancreatic beta-cells.	Amides	173-178	calmodulin 2	Mus musculus	58-68
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	23-74	calmodulin 2	Mus musculus	2-12
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	W 7	76-79	calmodulin 2	Mus musculus	2-12
11429650-5	2001	A calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7, 20 microM) completely reversed the inhibitory actions of GLP-1 on the membrane K(ATP) conductance and resultant membrane depolarization.	Adenosine Triphosphate	162-165	calmodulin 2	Mus musculus	2-12
10893236-4	2000	Bip, CalP, and CalM are calcium-binding proteins and implicated in calcium homeostasis, whereas SFRP-2 is a negative regulator of Wnt signaling.	Calcium	24-31	calmodulin 2	Mus musculus	15-19
10893236-4	2000	Bip, CalP, and CalM are calcium-binding proteins and implicated in calcium homeostasis, whereas SFRP-2 is a negative regulator of Wnt signaling.	Calcium	67-74	calmodulin 2	Mus musculus	15-19
11049221-2	2000	Zinc may also participate in the intracellular signal cascade by affecting cellular calcium influx and a change in the calcium-calmodulin (CaM)-cyclic adenosine monophosphate (cAMP) pathway.	Cyclic AMP	144-174	calmodulin 2	Mus musculus	119-137
11038246-4	2000	The nicotine-induced increase in DBI mRNA expression was inhibited by L-type voltage-dependent Ca(2+) channel (VDCC) inhibitors such as verapamil, calmodulin antagonist (W-7), and Ca(2+)/calmodulin-dependent protein kinase II (CAM II kinase) inhibitor (KN-62), whereas P/Q- and N-type VDCC inhibitors showed no effects.	Nicotine	4-12	calmodulin 2	Mus musculus	147-157
11049221-2	2000	Zinc may also participate in the intracellular signal cascade by affecting cellular calcium influx and a change in the calcium-calmodulin (CaM)-cyclic adenosine monophosphate (cAMP) pathway.	Cyclic AMP	144-174	calmodulin 2	Mus musculus	139-142
11049221-2	2000	Zinc may also participate in the intracellular signal cascade by affecting cellular calcium influx and a change in the calcium-calmodulin (CaM)-cyclic adenosine monophosphate (cAMP) pathway.	Cyclic AMP	176-180	calmodulin 2	Mus musculus	119-137
11049221-2	2000	Zinc may also participate in the intracellular signal cascade by affecting cellular calcium influx and a change in the calcium-calmodulin (CaM)-cyclic adenosine monophosphate (cAMP) pathway.	Cyclic AMP	176-180	calmodulin 2	Mus musculus	139-142
11049221-7	2000	This study indicated that there was an inverse interaction between CaM and cAMP in their cellular levels in the mouse adipocytes and that might be affected by exogenous zinc addition.	Cyclic AMP	75-79	calmodulin 2	Mus musculus	67-70
10970765-1	2000	Calmodulin (CaM) is a ubiquitous, highly conserved calcium sensor protein involved in the regulation of a wide variety of cellular events.	Calcium	51-58	calmodulin 2	Mus musculus	0-10
10913299-4	2000	PH1 was found to self-associate, and calmodulin or Ca(2+)-chelating agents such as ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) could effectively prevent this oligomerization.	Egtazic Acid	83-152	calmodulin 2	Mus musculus	37-47
10913299-6	2000	Since calmodulin inhibited syntrophin oligomerization in the presence or absence of Ca(2+), Ca(2+) binding to syntrophin is responsible for the inhibition by EGTA of syntrophin oligomerization.	Egtazic Acid	158-162	calmodulin 2	Mus musculus	6-16
10970765-1	2000	Calmodulin (CaM) is a ubiquitous, highly conserved calcium sensor protein involved in the regulation of a wide variety of cellular events.	Calcium	51-58	calmodulin 2	Mus musculus	12-15
10418102-5	1999	These results demonstrate that: (1) the calmodulin-dependent events taking place in spermatozoa before insemination appear essential at least for regular Ca2+ oscillations and for pronucleus formation; (2) the inhibition of calmodulin by calmidazolium applied to metaphase II oocytes before insemination has no major impact on their fertilising ability; and (3) at the time of gamete fusion calmodulin, either from the oocyte or from the spermatozoon, is essential for fertilisation to occur.	calmidazolium	238-251	calmodulin 2	Mus musculus	40-50
10775171-2	2000	The purpose of this study was to use the calmodulin (CaM) antagonists W7 and calmidazolium (CZ) to investigate the possible role of CaM, a Ca(2+)-specific binding protein, in capacitation.	calmidazolium	92-94	calmodulin 2	Mus musculus	41-51
10775171-2	2000	The purpose of this study was to use the calmodulin (CaM) antagonists W7 and calmidazolium (CZ) to investigate the possible role of CaM, a Ca(2+)-specific binding protein, in capacitation.	calmidazolium	92-94	calmodulin 2	Mus musculus	132-135
10775171-11	2000	These results suggest that CaM participates in the regulation of membrane changes important for mouse sperm capacitation, at a point upstream from cAMP, and that this pathway is at least partially separable from pathways controlling tyrosine phosphorylation and hyperactivation.	Cyclic AMP	147-151	calmodulin 2	Mus musculus	27-30
10673339-2	2000	Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases.	Calcium	23-30	calmodulin 2	Mus musculus	69-79
10673339-2	2000	Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases.	Calcium	23-30	calmodulin 2	Mus musculus	120-130
10673339-2	2000	Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases.	Calcium	23-30	calmodulin 2	Mus musculus	142-145
10590257-8	1999	The mice which were immunized with CAM, 2C4C2 and CAR scFv developed clinical manifestations of experimental anti-phospholipid syndrome.	Phospholipids	114-126	calmodulin 2	Mus musculus	35-38
10488077-3	1999	Calcium inhibited both of these activities, but the addition of calmodulin restored the values to approximately 70% of control, indicating that calmodulin dissociation caused inhibition.	Calcium	0-7	calmodulin 2	Mus musculus	144-154
10446976-3	1999	Idoxifene also inhibits calmodulin, a calcium-binding protein that is involved in cell signal transduction pathways.	idoxifene	0-9	calmodulin 2	Mus musculus	24-34
10446976-5	1999	The basis for idoxifene"s antitumor activity was examined by comparing the effectiveness of the clinically used transisomer (referred to here as idoxifene) with its cis-isomer, which has a 50-fold lower relative binding affinity for ER than idoxifene but similar calmodulin-inhibitory activity.	idoxifene	14-23	calmodulin 2	Mus musculus	263-273
10446976-12	1999	In conclusion, idoxifene resulted in similar inhibition of E2-dependent MCF-7 xenograft growth compared with tamoxifen, an effect that is mediated via ER rather than through calmodulin.	idoxifene	15-24	calmodulin 2	Mus musculus	174-184
10482245-0	1999	Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor.	Calcium	20-27	calmodulin 2	Mus musculus	0-10
10418102-5	1999	These results demonstrate that: (1) the calmodulin-dependent events taking place in spermatozoa before insemination appear essential at least for regular Ca2+ oscillations and for pronucleus formation; (2) the inhibition of calmodulin by calmidazolium applied to metaphase II oocytes before insemination has no major impact on their fertilising ability; and (3) at the time of gamete fusion calmodulin, either from the oocyte or from the spermatozoon, is essential for fertilisation to occur.	calmidazolium	238-251	calmodulin 2	Mus musculus	224-234
10418102-5	1999	These results demonstrate that: (1) the calmodulin-dependent events taking place in spermatozoa before insemination appear essential at least for regular Ca2+ oscillations and for pronucleus formation; (2) the inhibition of calmodulin by calmidazolium applied to metaphase II oocytes before insemination has no major impact on their fertilising ability; and (3) at the time of gamete fusion calmodulin, either from the oocyte or from the spermatozoon, is essential for fertilisation to occur.	calmidazolium	238-251	calmodulin 2	Mus musculus	224-234
10200558-1	1999	ALG-2 is a EF hand calcium binding protein with sequence homologies to calmodulin.	Calcium	19-26	calmodulin 2	Mus musculus	71-81
10207043-0	1999	Modulation of inositol 1,4,5-trisphosphate binding to the recombinant ligand-binding site of the type-1 inositol 1,4, 5-trisphosphate receptor by Ca2+ and calmodulin.	Inositol 1,4,5-Trisphosphate	14-42	calmodulin 2	Mus musculus	155-165
10207043-9	1999	Calmodulin also dose-dependently inhibited IP3 binding to Lbs-1 with an IC50 of about 3 microM.	Inositol 1,4,5-Trisphosphate	43-46	calmodulin 2	Mus musculus	0-10
10207043-12	1999	These results suggest that the N-terminal ligand-binding region of IP3R-1 contains a calmodulin-binding domain that binds calmodulin independently of Ca2+ and that mediates the inhibition of IP3 binding to IP3R-1.	Inositol 1,4,5-Trisphosphate	67-70	calmodulin 2	Mus musculus	85-95
10207043-12	1999	These results suggest that the N-terminal ligand-binding region of IP3R-1 contains a calmodulin-binding domain that binds calmodulin independently of Ca2+ and that mediates the inhibition of IP3 binding to IP3R-1.	Inositol 1,4,5-Trisphosphate	67-70	calmodulin 2	Mus musculus	122-132
9806822-4	1998	Econazole, iNOS inhibitor, calmodulin antagonist, 5-lipoxygenase and a specific thromboxane synthase inhibitor, at a 1 mg kg-1 dose significantly decreased the LPS-induced increase in nitrite levels, but increased mortality 4.	Nitrites	184-191	calmodulin 2	Mus musculus	27-37
9792538-8	1998	The calmodulin inhibitor W-7 and the myosin light-chain kinase inhibitor ML-9 decreased the motile events in the beta-cells under both nonstimulated and acetylcholine-stimulated conditions.	W 7	25-28	calmodulin 2	Mus musculus	4-14
9792538-8	1998	The calmodulin inhibitor W-7 and the myosin light-chain kinase inhibitor ML-9 decreased the motile events in the beta-cells under both nonstimulated and acetylcholine-stimulated conditions.	Acetylcholine	153-166	calmodulin 2	Mus musculus	4-14
9792538-9	1998	These findings led us to conclude that inositol trisphosphate [corrected] causes Ca2+ mobilization by muscarinic activation of PLC, leading to intracellular translocation of insulin granules to the ready-releasable pool in pancreatic beta-cells via Ca2+/calmodulin-dependent phosphorylation of myosin light chains.	inositol 1,2,3-trisphosphate	39-61	calmodulin 2	Mus musculus	254-264
9612395-14	1998	Simultaneous assessment of Cai2+ and LV function demonstrates that calmodulin-regulated mechanisms may contribute to the pathogenesis of myocardial stunning in the mouse heart.	cai2+	27-32	calmodulin 2	Mus musculus	67-77
9789026-6	1998	Inhibition of calmodulin with trifluoperazine induced its delocalization while morulae decompacted.	Trifluoperazine	30-45	calmodulin 2	Mus musculus	14-24
9596720-7	1998	The inhibitory assay suggested that butyric acid-induced apoptosis of WEHI 231 and splenic B cells was inhibited by W-7, a calmodulin inhibitor.	Butyric Acid	36-48	calmodulin 2	Mus musculus	123-133
9596720-7	1998	The inhibitory assay suggested that butyric acid-induced apoptosis of WEHI 231 and splenic B cells was inhibited by W-7, a calmodulin inhibitor.	W 7	116-119	calmodulin 2	Mus musculus	123-133
9596720-8	1998	These results suggest that calmodulin-dependent regulation is involved in the signal transduction pathway of butyric acid.	Butyric Acid	109-121	calmodulin 2	Mus musculus	27-37
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	Clotrimazole	30-42	calmodulin 2	Mus musculus	204-214
20654391-1	1998	The in vivo teratogenic potential of valproic acid (VPA) and related teratogenic and non-teratogenic analogues has been correlated with their effects on specific in vitro endpoints of cell proliferation, migration and CAM-dependent neurite outgrowth, as these events are common to crucial epochs of development.	Valproic Acid	37-50	calmodulin 2	Mus musculus	218-221
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	Clotrimazole	30-42	calmodulin 2	Mus musculus	232-242
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	1-(alpha-2-chlorotrityl)imidazole	44-77	calmodulin 2	Mus musculus	204-214
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	1-(alpha-2-chlorotrityl)imidazole	44-77	calmodulin 2	Mus musculus	232-242
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	bifonazole	83-93	calmodulin 2	Mus musculus	204-214
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	bifonazole	83-93	calmodulin 2	Mus musculus	232-242
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	1-(alpha-biphenyl-4-ylbenzyl)imidazole	95-133	calmodulin 2	Mus musculus	204-214
9544799-3	1998	We have previously found that clotrimazole (1-(alpha-2-chlorotrityl)imidazole) and bifonazole (1-(alpha-biphenyl-4-ylbenzyl)imidazole), the antifungal azole derivatives, which were recently recognized as calmodulin antagonists, are calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells.	1-(alpha-biphenyl-4-ylbenzyl)imidazole	95-133	calmodulin 2	Mus musculus	232-242
9929743-9	1998	The calmodulin antagonists inhibited the PMA-induced increase in CD44 expression on LB cells, but had no influence on the ability of the constitutive HA-binder HA9 cell line to interact with HA, indicating an effect on the PMA induction phase rather than on the binding itself.	Tetradecanoylphorbol Acetate	41-44	calmodulin 2	Mus musculus	4-14
9929743-8	1998	However, this PMA response was strongly inhibited by calmodulin antagonists (chlorpromazine, trifluoperazine, W-7) and the calcium blocker verapamil.	Chlorpromazine	77-91	calmodulin 2	Mus musculus	53-63
9316022-0	1997	Calmodulin is expressed by reactive microglia in the hippocampus of kainic acid-treated mice.	Kainic Acid	68-79	calmodulin 2	Mus musculus	0-10
9929743-8	1998	However, this PMA response was strongly inhibited by calmodulin antagonists (chlorpromazine, trifluoperazine, W-7) and the calcium blocker verapamil.	Trifluoperazine	93-108	calmodulin 2	Mus musculus	53-63
9929743-8	1998	However, this PMA response was strongly inhibited by calmodulin antagonists (chlorpromazine, trifluoperazine, W-7) and the calcium blocker verapamil.	W 7	110-113	calmodulin 2	Mus musculus	53-63
9316022-1	1997	Calmodulin is a calcium-binding protein that is highly abundant in the brain, where it is involved in many essential functions.	Calcium	16-23	calmodulin 2	Mus musculus	0-10
9316022-6	1997	In the present study, we found an increase in the expression of calmodulin in reactive microglial cells in the mouse hippocampus 24 h after an intraperitoneal administration of a convulsant dose of kainic acid.	Kainic Acid	198-209	calmodulin 2	Mus musculus	64-74
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Sepharose	55-64	calmodulin 2	Mus musculus	38-48
9384259-1	1997	We report the pharmacological characterization and cytoprotective effect of DY-9760e, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-( 4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, a novel antagonist of calmodulin.	3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate	76-84	calmodulin 2	Mus musculus	242-252
9384259-3	1997	These antagonistic effects of DY-9760e were more potent than those of W-7, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, another calmodulin antagonist.	3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate	30-38	calmodulin 2	Mus musculus	135-145
9384259-3	1997	These antagonistic effects of DY-9760e were more potent than those of W-7, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, another calmodulin antagonist.	w-7, n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide	70-125	calmodulin 2	Mus musculus	135-145
9384259-5	1997	Analysis of the hydrophobic interaction of DY-9760e with calmodulin by using 2-p-toluidinylnaphthalene-6-sulfonate and 9-anthroylcholine revealed that, like W-7, DY-9760e bound to the hydrophobic regions of calmodulin.	2-(4-toluidino)-6-naphthalenesulfonic acid	77-114	calmodulin 2	Mus musculus	57-67
9384259-5	1997	Analysis of the hydrophobic interaction of DY-9760e with calmodulin by using 2-p-toluidinylnaphthalene-6-sulfonate and 9-anthroylcholine revealed that, like W-7, DY-9760e bound to the hydrophobic regions of calmodulin.	9-anthroylcholine	119-136	calmodulin 2	Mus musculus	57-67
9378530-4	1997	Culturing murine splenocytes in presence of the isolated calmodulin binding proteins (10 micrograms protein/10(6) cells) resulted in nearly 4-fold enhancement of 3H-thymidine incorporation into them as compared to controls.	3h-thymidine	162-174	calmodulin 2	Mus musculus	57-67
9378530-6	1997	SDS-PAGE on 12.5 per cent gels of eluates obtained from calmodulin-agarose columns, followed by overlay of corresponding western blots with biotinylated calmodulin revealed the presence of a 68 kDa calmodulin binding protein in samples collected either at 28 wk or at full-term of pregnancy.	Sepharose	67-74	calmodulin 2	Mus musculus	56-66
9218707-2	1997	We have previously found that different calmodulin antagonists decrease the levels of allosteric activators of glycolysis, and reduce ATP content and cell viability in B16 melanoma cells.	Adenosine Triphosphate	134-137	calmodulin 2	Mus musculus	40-50
9187244-2	1997	Isoproterenol-stimulated adenylyl cyclase (IP-AC) activity in the membranes was increased by addition of the optimum concentrations of calcium/calmodulin.	Isoproterenol	0-13	calmodulin 2	Mus musculus	143-153
9187244-3	1997	However, in the presence of 0.01-0.07 mM glutathione (GSH), calcium/calmodulin inhibited the activity.	Glutathione	41-52	calmodulin 2	Mus musculus	68-78
9187244-3	1997	However, in the presence of 0.01-0.07 mM glutathione (GSH), calcium/calmodulin inhibited the activity.	Glutathione	54-57	calmodulin 2	Mus musculus	68-78
9187244-4	1997	At high concentrations of GSH (1-10 mM), the IP-AC activity was stimulated by calcium/calmodulin to a greater extent than that in the control (no GSH).	Glutathione	26-29	calmodulin 2	Mus musculus	86-96
9187244-6	1997	The activity of IP-AC measured in the absence of calmodulin decreased when calcium levels were greater than 300 microM.	ip-ac	16-21	calmodulin 2	Mus musculus	49-59
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Sepharose	55-64	calmodulin 2	Mus musculus	50-53
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Sepharose	55-64	calmodulin 2	Mus musculus	151-154
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Calcium	79-86	calmodulin 2	Mus musculus	38-48
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Calcium	79-86	calmodulin 2	Mus musculus	50-53
9115241-2	1997	Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells.	Calcium	79-86	calmodulin 2	Mus musculus	151-154
9115241-3	1997	The interaction is influenced by the guanine nucleotide binding state of Rad with the GDP-bound form exhibiting 5-fold better binding to CaM than the GTP-bound protein.	Guanine Nucleotides	37-55	calmodulin 2	Mus musculus	137-140
9115241-3	1997	The interaction is influenced by the guanine nucleotide binding state of Rad with the GDP-bound form exhibiting 5-fold better binding to CaM than the GTP-bound protein.	Guanosine Diphosphate	86-89	calmodulin 2	Mus musculus	137-140
9115241-3	1997	The interaction is influenced by the guanine nucleotide binding state of Rad with the GDP-bound form exhibiting 5-fold better binding to CaM than the GTP-bound protein.	Guanosine Triphosphate	150-153	calmodulin 2	Mus musculus	137-140
9115241-4	1997	In addition, the dominant negative mutant of Rad (S105N) which binds GDP, but not GTP, exhibits enhanced binding to CaM in vivo when expressed in C2C12 cells.	Guanosine Diphosphate	69-72	calmodulin 2	Mus musculus	116-119
9115241-10	1997	Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades.	Guanosine Triphosphate	24-27	calmodulin 2	Mus musculus	87-90
9115241-10	1997	Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades.	Guanosine Triphosphate	24-27	calmodulin 2	Mus musculus	95-105
9115241-10	1997	Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades.	Calcium	177-184	calmodulin 2	Mus musculus	87-90
9115241-10	1997	Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades.	Calcium	177-184	calmodulin 2	Mus musculus	95-105
8951173-1	1996	Calmodulin (CaM), a Ca(2+)-binding protein, is a multifunctional modulator mediating the calcium regulation of a large number of intracellular enzyme systems.	Calcium	89-96	calmodulin 2	Mus musculus	0-10
8954918-5	1996	Previous reports have shown that neomycin and W-7, which are inhibitors in the inositol phosphate/calmodulin pathway, blocked mechanical strain-induced proliferation of the osteoblast cells.	Neomycin	33-41	calmodulin 2	Mus musculus	98-108
8954918-5	1996	Previous reports have shown that neomycin and W-7, which are inhibitors in the inositol phosphate/calmodulin pathway, blocked mechanical strain-induced proliferation of the osteoblast cells.	W 7	46-49	calmodulin 2	Mus musculus	98-108
9135097-3	1997	We studied the expression of calmodulin in the mouse brain at different times after the administration of a convulsant dose of kainate, a potent neuroexcitotoxic agent.	Kainic Acid	127-134	calmodulin 2	Mus musculus	29-39
9135097-11	1997	Kainate treatment induced modifications in the expression of calmodulin at the level of both messenger RNAs and protein.	Kainic Acid	0-7	calmodulin 2	Mus musculus	61-71
8951173-1	1996	Calmodulin (CaM), a Ca(2+)-binding protein, is a multifunctional modulator mediating the calcium regulation of a large number of intracellular enzyme systems.	Calcium	89-96	calmodulin 2	Mus musculus	12-15
8900147-3	1996	In cells expressing wild-type neuromodulin, a complex with calmodulin that is sensitive to intracellular calcium and phosphorylation is localized to the plasma membrane.	Calcium	105-112	calmodulin 2	Mus musculus	59-69
8890207-11	1996	Rabbit anti-mannan antibodies administered by intraperitoneal injection 24 h before CAM injection significantly suppressed (P < 0.05) the accumulation of TNF-alpha in the sera.	Mannans	12-18	calmodulin 2	Mus musculus	84-87
9414428-5	1996	During the apoptotic process induced by TGF-beta 1, mRNA expression of testosterone repressed prostatic message-2, glucose regulated 78 kDa protein, and calmodulin increased.	Testosterone	71-83	calmodulin 2	Mus musculus	153-163
8887637-11	1996	Type I adenylyl cyclase has two CaM kinase IV consensus phosphorylation sequences near its CaM binding domain at Ser-545 and Ser-552.	Serine	113-116	calmodulin 2	Mus musculus	32-35
8887637-11	1996	Type I adenylyl cyclase has two CaM kinase IV consensus phosphorylation sequences near its CaM binding domain at Ser-545 and Ser-552.	Serine	113-116	calmodulin 2	Mus musculus	91-94
8887637-12	1996	Conversion of either serine to alanine by mutagenesis abolished CaM kinase IV inhibition of adenylyl cyclase.	Serine	21-27	calmodulin 2	Mus musculus	64-67
8887637-12	1996	Conversion of either serine to alanine by mutagenesis abolished CaM kinase IV inhibition of adenylyl cyclase.	Alanine	31-38	calmodulin 2	Mus musculus	64-67
8887637-15	1996	We propose that CaM kinase IV may function as a negative feedback regulator of type I adenylyl cyclase and that CaM kinases may regulate cAMP levels in some cells.	Cyclic AMP	137-141	calmodulin 2	Mus musculus	112-115
8911923-0	1996	Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells.	glucose-1,6-bisphosphate	32-56	calmodulin 2	Mus musculus	0-10
8911923-0	1996	Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells.	fructose-1,6-diphosphate	58-83	calmodulin 2	Mus musculus	0-10
8911923-0	1996	Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells.	Adenosine Triphosphate	85-88	calmodulin 2	Mus musculus	0-10
8911923-6	1996	These findings suggest that the fall in the levels of the two signal molecules of glycolysis, induced by the calmodulin antagonists, causes a reduction in glycolysis and ATP levels, which eventually leads to cell death.	Adenosine Triphosphate	170-173	calmodulin 2	Mus musculus	109-119
8911923-7	1996	Since cell proliferation was also reported to be inhibited by calmodulin antagonists, these substances are most promising agents in treatment of cancer by inhibiting both cell proliferation and the glycolytic supply of ATP required for cell growth.	Adenosine Triphosphate	219-222	calmodulin 2	Mus musculus	62-72
8670224-5	1996	The calmodulin-replete iNOS was dimeric, contained normal quantities of heme, flavins, and tightly bound calmodulin, and had high NO synthesis activity (0.7 - 1.2 mumol NO/min per mg).	Heme	72-76	calmodulin 2	Mus musculus	4-14
8905336-0	1996	Effects of calmodulin antagonists and anesthetics on the skin lesions induced by 2-chloroethylethyl sulfide.	2-chloroethyl ethyl sulfide	81-107	calmodulin 2	Mus musculus	11-21
8905336-5	1996	Trifluoperazine (0.5-1%) and thioridazine (2%), potent calmodulin antagonists, in Pluronic F-127 base substantially prevented the development of 2-chloroethylethyl sulfide-induced skin lesions.	Thioridazine	29-41	calmodulin 2	Mus musculus	55-65
8905336-5	1996	Trifluoperazine (0.5-1%) and thioridazine (2%), potent calmodulin antagonists, in Pluronic F-127 base substantially prevented the development of 2-chloroethylethyl sulfide-induced skin lesions.	Poloxamer	82-96	calmodulin 2	Mus musculus	55-65
8905336-5	1996	Trifluoperazine (0.5-1%) and thioridazine (2%), potent calmodulin antagonists, in Pluronic F-127 base substantially prevented the development of 2-chloroethylethyl sulfide-induced skin lesions.	2-chloroethyl ethyl sulfide	145-171	calmodulin 2	Mus musculus	55-65
8905336-6	1996	A similar effect was achieved with pentamidine (10%), another type of calmodulin antagonist, but not with ketoconazole, a weak calmodulin antagonist.	Pentamidine	35-46	calmodulin 2	Mus musculus	70-80
8905336-9	1996	These results suggest that some calmodulin antagonists and anesthetics in water-soluble bases might be a choice for the treatment of 2-chloroethylethyl sulfide-induced skin burns.	Water	74-79	calmodulin 2	Mus musculus	32-42
8905336-9	1996	These results suggest that some calmodulin antagonists and anesthetics in water-soluble bases might be a choice for the treatment of 2-chloroethylethyl sulfide-induced skin burns.	2-chloroethyl ethyl sulfide	133-159	calmodulin 2	Mus musculus	32-42
8756293-9	1996	Morulae exposed to the calmodulin inhibitor W-7 exhibited a dose-dependent delay in blastocoel formation.	W 7	44-47	calmodulin 2	Mus musculus	23-33
8877815-9	1996	A common mediator of the inhibitory actions of calcium may be the calcium receptor protein calmodulin the de novo synthesis of which is rapidly stimulated by glucocorticoid hormones.	Calcium	47-54	calmodulin 2	Mus musculus	91-101
8781543-3	1996	An activity sensitive to CaCl2/calmodulin, which could not be detected in membranes from untreated cells, was found in membranes from A23187-treated cells.	Calcimycin	134-140	calmodulin 2	Mus musculus	31-41
8670224-5	1996	The calmodulin-replete iNOS was dimeric, contained normal quantities of heme, flavins, and tightly bound calmodulin, and had high NO synthesis activity (0.7 - 1.2 mumol NO/min per mg).	Flavins	78-85	calmodulin 2	Mus musculus	4-14
8670224-6	1996	In contrast, calmodulin-deficient iNOS was monomeric, devoid of flavins and heme, and had no NO synthesis activity.	Flavins	64-71	calmodulin 2	Mus musculus	13-23
8670224-6	1996	In contrast, calmodulin-deficient iNOS was monomeric, devoid of flavins and heme, and had no NO synthesis activity.	Heme	76-80	calmodulin 2	Mus musculus	13-23
8552251-6	1995	Infusions of the calmodulin antagonist calmidazolium during the critical period prevented memory formation.	calmidazolium	39-52	calmodulin 2	Mus musculus	17-27
8780216-4	1996	These transgenic mice overexpress a calmodulin minigene regulated by the rat insulin II promotor, resulting in severe diabetes characterized by elevated blood glucose and glucagon that coincides with reduced serum and pancreatic insulin.	Glucagon	171-179	calmodulin 2	Mus musculus	36-46
8619889-8	1996	In addition, deltamethrin-1R induced a transient increase of [Ca2+]i mobilization in the thymocyte suspension after 10 min of in vitro treatment, and substantially reduced the rate of calcium-calmodulin (Ca/CaM)-dependent protein dephosphorylation in in vivo treated animals (25 mg deltamethrin/kg for 24 hr).	deltamethrin-1r	13-28	calmodulin 2	Mus musculus	192-202
8619889-8	1996	In addition, deltamethrin-1R induced a transient increase of [Ca2+]i mobilization in the thymocyte suspension after 10 min of in vitro treatment, and substantially reduced the rate of calcium-calmodulin (Ca/CaM)-dependent protein dephosphorylation in in vivo treated animals (25 mg deltamethrin/kg for 24 hr).	decamethrin	13-25	calmodulin 2	Mus musculus	192-202
8619889-12	1996	In addition, the involvement of the Ca/CaM-dependent protein phosphorylation-dephosphorylation cascade in the induction of apoptosis by deltamethrin was supported by the protective role of the calmodulin inhibitor trifluoperazine against the apoptotic effect of deltamethrin on thymocyte suspension.	decamethrin	136-148	calmodulin 2	Mus musculus	193-203
8619889-12	1996	In addition, the involvement of the Ca/CaM-dependent protein phosphorylation-dephosphorylation cascade in the induction of apoptosis by deltamethrin was supported by the protective role of the calmodulin inhibitor trifluoperazine against the apoptotic effect of deltamethrin on thymocyte suspension.	Trifluoperazine	214-229	calmodulin 2	Mus musculus	193-203
8619889-12	1996	In addition, the involvement of the Ca/CaM-dependent protein phosphorylation-dephosphorylation cascade in the induction of apoptosis by deltamethrin was supported by the protective role of the calmodulin inhibitor trifluoperazine against the apoptotic effect of deltamethrin on thymocyte suspension.	decamethrin	262-274	calmodulin 2	Mus musculus	193-203
7495792-9	1995	EGTA also changed the native PAGE mobility of iNOS and increased the intensity of a band which comigrates with CaM.	Egtazic Acid	0-4	calmodulin 2	Mus musculus	111-114
8722699-4	1996	Sperm preincubated in the presence of trifluoperazine (TFP), a calmodulin antagonist, were significantly more fertile than cells from the same males incubated in the absence of TFP, indicating that inhibition of calmodulin accelerates capacitation.	Trifluoperazine	38-53	calmodulin 2	Mus musculus	63-73
8722699-4	1996	Sperm preincubated in the presence of trifluoperazine (TFP), a calmodulin antagonist, were significantly more fertile than cells from the same males incubated in the absence of TFP, indicating that inhibition of calmodulin accelerates capacitation.	Trifluoperazine	38-53	calmodulin 2	Mus musculus	212-222
8636075-2	1996	This fusion protein, called DysS9, bound to calmodulin-Sepharose, bound biotinylated calmodulin, caused characteristic changes in the fluorescence emission spectrum of dansyl-calmodulin, and had an apparent affinity for dansyl-calmodulin of 54 nM.	Sepharose	55-64	calmodulin 2	Mus musculus	44-54
9284569-3	1996	In these animals, the excess of calmodulin decreases the cytosolic calcium levels in beta cells, leading to morphological and functional alterations that produce a severe IDDM.	Calcium	67-74	calmodulin 2	Mus musculus	32-42
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	W 7	24-27	calmodulin 2	Mus musculus	0-10
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	W 7	24-27	calmodulin 2	Mus musculus	159-169
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	Trifluoperazine	45-60	calmodulin 2	Mus musculus	0-10
8750956-8	1995	Calmodulin antagonists, W-7 (100 microM) and trifluoperazine (10 microM), were also effective, although at concentrations well above those required to inhibit calmodulin.	Trifluoperazine	45-60	calmodulin 2	Mus musculus	159-169
7499389-9	1995	These data support the contention that excessive levels of calmodulin may compromise the ability of the beta cell to metabolize glucose and to modulate the state of the K+ATP channel, resulting in an inadequate control of the membrane potential, which collectively impair [Ca2+]i and thus insulin secretion in response to glucose.	Glucose	128-135	calmodulin 2	Mus musculus	59-69
7499389-9	1995	These data support the contention that excessive levels of calmodulin may compromise the ability of the beta cell to metabolize glucose and to modulate the state of the K+ATP channel, resulting in an inadequate control of the membrane potential, which collectively impair [Ca2+]i and thus insulin secretion in response to glucose.	Glucose	322-329	calmodulin 2	Mus musculus	59-69
7631156-5	1995	BALB/c mice were immunized with anti-cardiolipin monoclonal antibody (MoAb) named CAM and developed elevated serum titres of anti-phospholipid Abs accompanied by prolonged activated partial thromboplastin time, thrombocytopenia and a high percentage of fetal resorptions.	Phospholipids	130-142	calmodulin 2	Mus musculus	82-85
7653598-0	1995	Glyburide attenuates calmodulin antagonist-stimulated renin release from isolated mouse juxtaglomerular cells.	Glyburide	0-9	calmodulin 2	Mus musculus	21-31
7653598-2	1995	Therefore, we examined whether the K+ channel blocker, glyburide, inhibits basal RR or RR stimulated by elevating cAMP or by inhibiting Ca2+/calmodulin activity in cultures of isolated mouse JG cells.	Glyburide	55-64	calmodulin 2	Mus musculus	141-151
7653598-5	1995	In contrast, glyburide significantly attenuated RR stimulated by the calmodulin antagonists, calmidazolium, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7).	Glyburide	13-22	calmodulin 2	Mus musculus	69-79
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	26-76	calmodulin 2	Mus musculus	4-14
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	W 7	78-81	calmodulin 2	Mus musculus	4-14
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	Hexachlorocyclohexane	93-120	calmodulin 2	Mus musculus	4-14
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	Pentylenetetrazole	136-154	calmodulin 2	Mus musculus	4-14
7561871-4	1995	The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) abolished gamma-hexachlorocyclohexane-, Bay K 8644-, pentylenetetrazole-, and kainic acid-induced increases in c-fos expression in cultured neurons.	Kainic Acid	161-172	calmodulin 2	Mus musculus	4-14
7561871-11	1995	Calmodulin may mediate neuronal responses depending on the route by which calcium enters the neuron, resulting in activation of different enzymes.	Calcium	74-81	calmodulin 2	Mus musculus	0-10
7768614-6	1995	14CO2 production from L-[14C]glutamine in Percoll-density-gradient-purified E. risticii was inhibited by A23187 but not by W-7 or verapamil, suggesting that Ca2+ but not calmodulin directly regulates ehrlichials glutamine oxidation.	14co2	0-5	calmodulin 2	Mus musculus	170-180
7768614-6	1995	14CO2 production from L-[14C]glutamine in Percoll-density-gradient-purified E. risticii was inhibited by A23187 but not by W-7 or verapamil, suggesting that Ca2+ but not calmodulin directly regulates ehrlichials glutamine oxidation.	Calcimycin	105-111	calmodulin 2	Mus musculus	170-180
7704899-5	1995	These data were supported by the in vitro nonspecific effect of CD8 cells induced in vivo by bromocriptine, on specific lymph node cell proliferation in the presence of the pathogenic monoclonal antibodies (MIV-7 or CAM, respectively), and on the response to an irrelevant autoantigen, myelin basic protein.	Bromocriptine	93-106	calmodulin 2	Mus musculus	216-219
8574143-0	1995	Calmodulin inhibitors and calcium channel blockers influence dideoxycytidine renal excretion.	Zalcitabine	61-76	calmodulin 2	Mus musculus	0-10
7533187-6	1995	Although primary macrophage iNOS underwent phosphorylation, ubiquitinylation, and binding of calmodulin tightly enough to resist boiling in SDS, these modifications did not allow us to distinguish between the cytosolic and particulate variants.	Sodium Dodecyl Sulfate	140-143	calmodulin 2	Mus musculus	93-103
7887964-3	1995	We report here that CaM can interact in a calcium-dependent manner with the untransformed glucocorticoid receptor (GR) complex containing hsp90.	Calcium	42-49	calmodulin 2	Mus musculus	20-23
7887964-4	1995	In addition, we demonstrate that four unrelated CaM antagonists (trifluoperazine, compound 48/80, W7, and phenoxybenzamine) can inhibit GR-mediated gene expression in mouse L929 cells stably-transfected with the MMTV-CAT reporter gene.	Trifluoperazine	65-80	calmodulin 2	Mus musculus	48-51
7887964-4	1995	In addition, we demonstrate that four unrelated CaM antagonists (trifluoperazine, compound 48/80, W7, and phenoxybenzamine) can inhibit GR-mediated gene expression in mouse L929 cells stably-transfected with the MMTV-CAT reporter gene.	Phenoxybenzamine	106-122	calmodulin 2	Mus musculus	48-51
7599959-4	1995	In the present study we show that the neurite outgrowth stimulated by the above three CAMs, FGF, arachidonic acid (AA), and K+ depolarization can be abolished by the Ca2+/calmodulin-dependent (CaM) kinase inhibitor, KN-62.	KN 62	216-221	calmodulin 2	Mus musculus	193-196
7599959-5	1995	We also demonstrate that neurite outgrowth over astrocytes, which represent a more physiologically relevant cellular substrate, can be substantially inhibited by a number of agents that block the CAM signaling pathway, including KN-62.	KN 62	229-234	calmodulin 2	Mus musculus	196-199
7599959-7	1995	These results suggest that CaM kinase activity is specifically required downstream of calcium influx in the CAM and FGF signaling pathway leading to axonal growth.	Calcium	86-93	calmodulin 2	Mus musculus	27-30
7599959-7	1995	These results suggest that CaM kinase activity is specifically required downstream of calcium influx in the CAM and FGF signaling pathway leading to axonal growth.	Calcium	86-93	calmodulin 2	Mus musculus	108-111
7599959-4	1995	In the present study we show that the neurite outgrowth stimulated by the above three CAMs, FGF, arachidonic acid (AA), and K+ depolarization can be abolished by the Ca2+/calmodulin-dependent (CaM) kinase inhibitor, KN-62.	Arachidonic Acid	97-113	calmodulin 2	Mus musculus	193-196
8574143-4	1995	Pre-exposure of mice to the calmodulin inhibitors loperamide (LOP) and trifluoperazine (TFP) resulted in a decrease in ddC renal secretion while pre-treatment with the calcium channel blocker verapamil increased ddC secretion.	Loperamide	50-60	calmodulin 2	Mus musculus	28-38
8574143-4	1995	Pre-exposure of mice to the calmodulin inhibitors loperamide (LOP) and trifluoperazine (TFP) resulted in a decrease in ddC renal secretion while pre-treatment with the calcium channel blocker verapamil increased ddC secretion.	Loperamide	62-65	calmodulin 2	Mus musculus	28-38
8574143-4	1995	Pre-exposure of mice to the calmodulin inhibitors loperamide (LOP) and trifluoperazine (TFP) resulted in a decrease in ddC renal secretion while pre-treatment with the calcium channel blocker verapamil increased ddC secretion.	Trifluoperazine	71-86	calmodulin 2	Mus musculus	28-38
8574143-4	1995	Pre-exposure of mice to the calmodulin inhibitors loperamide (LOP) and trifluoperazine (TFP) resulted in a decrease in ddC renal secretion while pre-treatment with the calcium channel blocker verapamil increased ddC secretion.	Verapamil	192-201	calmodulin 2	Mus musculus	28-38
8574143-4	1995	Pre-exposure of mice to the calmodulin inhibitors loperamide (LOP) and trifluoperazine (TFP) resulted in a decrease in ddC renal secretion while pre-treatment with the calcium channel blocker verapamil increased ddC secretion.	Zalcitabine	119-122	calmodulin 2	Mus musculus	28-38
7828884-0	1994	Three different calmodulin-encoding cDNAs isolated by a modified 5"-RACE using degenerate oligodeoxyribonucleotides.	5"-race	65-72	calmodulin 2	Mus musculus	16-26
7874572-5	1995	W-7, a calmodulin inhibitor, decreased ODC enzyme activity in a dose-dependent, reversible fashion while trifluoperazine, another calmodulin inhibitor, failed to affect ODC enzyme activity in MC-26 cells.	W 7	0-3	calmodulin 2	Mus musculus	7-17
7828884-0	1994	Three different calmodulin-encoding cDNAs isolated by a modified 5"-RACE using degenerate oligodeoxyribonucleotides.	Oligodeoxyribonucleotides	90-115	calmodulin 2	Mus musculus	16-26
7828884-1	1994	In order to obtain the 5" ends of the three mouse calmodulin (CaM) cDNAs, we modified the standard 5" RACE (rapid amplification of cDNA ends) method to use degenerate synthetic oligodeoxyribonucleotides to prime cDNA synthesis of all three CaM mRNAs.	Oligodeoxyribonucleotides	177-202	calmodulin 2	Mus musculus	62-65
7705961-0	1994	Role of calcium and calmodulin in the activation of murine peritoneal macrophages with cisplatin.	Cisplatin	87-96	calmodulin 2	Mus musculus	20-30
7705961-2	1994	Calcium modulating agents, EGTA, nifedipine, and TMB-8, and the calmodulin antagonist W-7 inhibited cisplatin-induced tumoricidal activity of murine peritoneal macrophages.	Cisplatin	100-109	calmodulin 2	Mus musculus	64-74
7705961-4	1994	Similarly, TNF and IL-1 activity were significantly inhibited in paraformaldehyde (PFA)-fixed macrophages and freeze-thaw lysates of macrophages treated with cisplatin and different calcium and calmodulin-modulating agents.	paraform	83-86	calmodulin 2	Mus musculus	194-204
7705961-5	1994	These results suggest that calcium and calmodulin are important in the cisplatin-mediated activation of murine peritoneal macrophages to tumoricidal state.	Cisplatin	71-80	calmodulin 2	Mus musculus	39-49
7929404-6	1994	Also, removal of external calcium or cell treatment with the calmodulin antagonist trifluoperazine did not affect PA-induced AA release, while inhibiting the responses to zymosan, phorbol 12-myristate 13-acetate, and ionophore A23187.	Trifluoperazine	83-98	calmodulin 2	Mus musculus	61-71
7961759-0	1994	Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles.	Phospholipids	86-98	calmodulin 2	Mus musculus	42-52
8002379-3	1994	PS-990 inhibited brain calcium calmodulin-dependent cyclic nucleotide phosphodiesterase with an IC50 value of 3 micrograms/ml, and markedly induced neurite extension of mouse neuroblastoma, Neuro2A, at concentrations ranging from 10 to 30 micrograms ml.	PS 990	0-6	calmodulin 2	Mus musculus	31-41
7929404-6	1994	Also, removal of external calcium or cell treatment with the calmodulin antagonist trifluoperazine did not affect PA-induced AA release, while inhibiting the responses to zymosan, phorbol 12-myristate 13-acetate, and ionophore A23187.	Zymosan	171-178	calmodulin 2	Mus musculus	61-71
7531829-0	1994	Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression.	Hexachlorocyclohexane	79-86	calmodulin 2	Mus musculus	27-37
7531829-0	1994	Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression.	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	91-100	calmodulin 2	Mus musculus	27-37
8132706-4	1994	CAM stimulated neurite outgrowth can be accounted for by a G-protein-dependent activation of neuronal calcium channels; experiments with agents that directly activate this pathway localized the erbstatin analogue site of action upstream of the G-protein and calcium channels, whereas tyrphostins have sites of action downstream from calcium channel activation.	erbstatin	194-203	calmodulin 2	Mus musculus	0-3
7531829-11	1994	Our results suggest that lindane as BayK-8644 may activate voltage-dependent calcium channels leading to calmodulin activation.	Hexachlorocyclohexane	25-32	calmodulin 2	Mus musculus	105-115
7855067-4	1994	In seeking a calmodulin antagonist that could be used clinically, we investigated tamoxifen, which is known to have calmodulin antagonist activity in vitro, and confirmed that it will inhibit murine melanoma cell attachment in vitro.	Tamoxifen	82-91	calmodulin 2	Mus musculus	13-23
7855067-4	1994	In seeking a calmodulin antagonist that could be used clinically, we investigated tamoxifen, which is known to have calmodulin antagonist activity in vitro, and confirmed that it will inhibit murine melanoma cell attachment in vitro.	Tamoxifen	82-91	calmodulin 2	Mus musculus	116-126
8189230-7	1994	Conversely, [14C]guanidinium influx due to the latter substances could be reversibly and dose-dependently blocked by various drugs that possess calmodulin-antagonizing properties.	Carbon-14	13-16	calmodulin 2	Mus musculus	144-154
8189230-7	1994	Conversely, [14C]guanidinium influx due to the latter substances could be reversibly and dose-dependently blocked by various drugs that possess calmodulin-antagonizing properties.	Guanidine	17-28	calmodulin 2	Mus musculus	144-154
8189230-8	1994	These results strongly suggest that the cation permeability opened by 5-HT and substance P in NG 108-15 cells involves a calcium/calmodulin-dependent process.	Calcium	121-128	calmodulin 2	Mus musculus	129-139
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	Cadmium	35-42	calmodulin 2	Mus musculus	120-130
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	Chlorpromazine	150-164	calmodulin 2	Mus musculus	120-130
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	Chlorpromazine	166-169	calmodulin 2	Mus musculus	120-130
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	Trifluoperazine	172-187	calmodulin 2	Mus musculus	120-130
8207755-1	1994	A recent report has indicated that cadmium-induced testicular damage in CF-1 mice can be prevented by pretreatment with calmodulin inhibitors such as chlorpromazine (CPZ), trifluoperazine, or N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide (W-7).	W 7	245-248	calmodulin 2	Mus musculus	120-130
8166638-9	1994	Addition of calmodulin to the baculovirus-expressed gamma stimulates its activity 1.5-2.0 fold at pH 6.8 in both the presence and absence of calcium.	Calcium	141-148	calmodulin 2	Mus musculus	12-22
8166638-12	1994	This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin.	Calcium	112-119	calmodulin 2	Mus musculus	36-46
8166638-12	1994	This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin.	Calcium	112-119	calmodulin 2	Mus musculus	77-87
8166638-12	1994	This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin.	Calcium	112-119	calmodulin 2	Mus musculus	77-87
8166638-14	1994	of gamma in the presence of calmodulin and in the absence of calcium presents a novel mechanism for the regulation of a calmodulin-stimulated kinase.	Calcium	61-68	calmodulin 2	Mus musculus	120-130
8132706-4	1994	CAM stimulated neurite outgrowth can be accounted for by a G-protein-dependent activation of neuronal calcium channels; experiments with agents that directly activate this pathway localized the erbstatin analogue site of action upstream of the G-protein and calcium channels, whereas tyrphostins have sites of action downstream from calcium channel activation.	Tyrphostins	284-295	calmodulin 2	Mus musculus	0-3
8359270-0	1993	Calmodulin mediates melatonin cytoskeletal effects.	Melatonin	20-29	calmodulin 2	Mus musculus	0-10
8313997-5	1994	In vitro experiments with [35S]-met showed that the highly abundant CaM accumulating in vitellogenic follicles may not all be synthesized by the oocyte.	Sulfur-35	27-30	calmodulin 2	Mus musculus	68-71
8313997-6	1994	Isolated follicle cells incorporate 13-fold more [35S]-met into CaM than the oocytes themselves but do not accumulate the product.	Sulfur-35	50-53	calmodulin 2	Mus musculus	64-67
7694769-0	1993	Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs.	Hexachlorocyclohexane	113-120	calmodulin 2	Mus musculus	67-77
8286225-1	1993	Signal transduction of many intracellular events is initiated by a minute influx of calcium ions into the cells, resulting in the formation of calcium-calmodulin complex and cAMP.	Calcium	84-91	calmodulin 2	Mus musculus	151-161
8286225-6	1993	Overall, the relationship between calmodulin and cAMP appeared to be inversely logarithmic, with the lowest calmodulin levels associated with the highest cAMP concentrations.	Cyclic AMP	49-53	calmodulin 2	Mus musculus	34-44
8286225-6	1993	Overall, the relationship between calmodulin and cAMP appeared to be inversely logarithmic, with the lowest calmodulin levels associated with the highest cAMP concentrations.	Cyclic AMP	49-53	calmodulin 2	Mus musculus	108-118
8286225-6	1993	Overall, the relationship between calmodulin and cAMP appeared to be inversely logarithmic, with the lowest calmodulin levels associated with the highest cAMP concentrations.	Cyclic AMP	154-158	calmodulin 2	Mus musculus	34-44
8286225-6	1993	Overall, the relationship between calmodulin and cAMP appeared to be inversely logarithmic, with the lowest calmodulin levels associated with the highest cAMP concentrations.	Cyclic AMP	154-158	calmodulin 2	Mus musculus	108-118
8227084-13	1993	Actinomycin D prevented the induction by hOP-1 of L1 and N-CAM mRNAs, suggesting that hOP-1 regulates immunoglobulin CAM gene transcription.	Dactinomycin	0-13	calmodulin 2	Mus musculus	59-62
7506289-5	1993	A calmodulin inhibitor (W-7) showed no effect on IL-1 beta-induced NOx production, whereas cycloheximide and the actinomycin D completely inhibited NOx production.	W 7	24-27	calmodulin 2	Mus musculus	2-12
8359270-5	1993	At higher concentrations (10(-5)M) non-specific binding of melatonin to tubulin occurs thus overcoming the specific melatonin antagonism to Ca2+-calmodulin.	Melatonin	59-68	calmodulin 2	Mus musculus	145-155
8359270-5	1993	At higher concentrations (10(-5)M) non-specific binding of melatonin to tubulin occurs thus overcoming the specific melatonin antagonism to Ca2+-calmodulin.	Melatonin	116-125	calmodulin 2	Mus musculus	145-155
8359270-6	1993	Since the structures of melatonin and calmodulin are phylogenetically well preserved, calmodulin-melatonin interaction probably represents a major mechanism for regulation and synchronization of cell physiology.	Melatonin	24-33	calmodulin 2	Mus musculus	86-96
8359270-1	1993	In this article, we review the data concerning melatonin interactions with calmodulin.	Melatonin	47-56	calmodulin 2	Mus musculus	75-85
8359270-3	1993	Melatonin interaction with calmodulin may allow the hormone to modulate rhythmically many cellular functions.	Melatonin	0-9	calmodulin 2	Mus musculus	27-37
8359270-4	1993	Melatonin"s effect on tubulin polymerization, and cytoskeletal changes in MDCK and N1E-115 cells cultured with melatonin, suggest that at low concentrations (10(-9) M) cytoskeletal effects are mediated by its antagonism to Ca2+-calmodulin.	Melatonin	0-9	calmodulin 2	Mus musculus	228-238
8099806-0	1993	Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype.	Trifluoperazine	21-36	calmodulin 2	Mus musculus	0-10
8393942-0	1993	Effects of diethyldithiocarbamate on calmodulin in neuroblastoma cells.	Ditiocarb	11-33	calmodulin 2	Mus musculus	37-47
8393942-2	1993	Cell injury caused by DDC affects the calcium-binding protein calmodulin (CaM) and alters copper homeostasis in these cells.	Ditiocarb	22-25	calmodulin 2	Mus musculus	62-72
8393942-2	1993	Cell injury caused by DDC affects the calcium-binding protein calmodulin (CaM) and alters copper homeostasis in these cells.	Ditiocarb	22-25	calmodulin 2	Mus musculus	74-77
8393942-8	1993	Staining of electrophoretic transfers by ProtoGold showed that CaM was present in all control samples and treated samples through 6 h. Atomic absorption spectrophotometry showed no difference in calcium levels between control and treated samples, but copper levels were significantly elevated.	Copper	251-257	calmodulin 2	Mus musculus	63-66
8393942-9	1993	This study indicated that degenerative changes induced by DDC altered calmodulin levels.	Ditiocarb	58-61	calmodulin 2	Mus musculus	70-80
8499453-0	1993	Inhibition of mitochondrial translation by calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide.	W 7	65-115	calmodulin 2	Mus musculus	43-53
8433352-9	1993	The microfilament reorganization during RVD is abolished by the calmodulin antagonists pimozide and trifluoperazine, suggesting the involvement of calmodulin in the process.	Pimozide	87-95	calmodulin 2	Mus musculus	64-74
8384025-0	1993	The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells.	calmidazolium	26-39	calmodulin 2	Mus musculus	4-14
8384025-0	1993	The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells.	Nitric Oxide	62-74	calmodulin 2	Mus musculus	4-14
8384025-3	1993	Instead of the expected decrease in NO generation based on the calmodulin dependence of neuronal NO synthase, calmidazoline paradoxically increased cyclic GMP formation.	calmidazoline	110-123	calmodulin 2	Mus musculus	63-73
8156166-5	1993	The effect was more pronounced when the calmodulin antagonist flunarizine was used or the proteinkinase C inhibitors dequalinium, tamoxifen and H-7 were applied.	Flunarizine	62-73	calmodulin 2	Mus musculus	40-50
7680676-4	1993	Lymphocyte proliferation was inhibited during both the phases of immune response by verapamil, a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor.	Trifluoperazine	129-144	calmodulin 2	Mus musculus	148-158
8433352-9	1993	The microfilament reorganization during RVD is abolished by the calmodulin antagonists pimozide and trifluoperazine, suggesting the involvement of calmodulin in the process.	Pimozide	87-95	calmodulin 2	Mus musculus	147-157
8433352-9	1993	The microfilament reorganization during RVD is abolished by the calmodulin antagonists pimozide and trifluoperazine, suggesting the involvement of calmodulin in the process.	Trifluoperazine	100-115	calmodulin 2	Mus musculus	64-74
8433352-9	1993	The microfilament reorganization during RVD is abolished by the calmodulin antagonists pimozide and trifluoperazine, suggesting the involvement of calmodulin in the process.	Trifluoperazine	100-115	calmodulin 2	Mus musculus	147-157
8427023-1	1993	The ED50 value of cyanide as measured by induction of convulsions (tonic seizure) was significantly increased by 80% or 69% when trifluoperazine (TFP) or chlorpromazine (CHP), a specific calmodulin inhibitor was preinjected intracerebroventricularly (i.v.t.)	Trifluoperazine	146-149	calmodulin 2	Mus musculus	187-197
8427023-4	1993	Since it is known that the inhibitory effect of TFP or CHP against calmodulin-dependent enzymes such as phosphodiesterase is 100-400-fold higher compared to PMZ, it is speculated that the inhibitory effect of TFP or CHP against cyanide-induced convulsions may be based on its strong inhibitory properties into calmodulin-dependent enzymes.	Promethazine	157-160	calmodulin 2	Mus musculus	67-77
8427023-0	1993	Protective effect of calmodulin inhibitors against acute cyanide-induced lethality and convulsions in mice.	Cyanides	57-64	calmodulin 2	Mus musculus	21-31
8427023-1	1993	The ED50 value of cyanide as measured by induction of convulsions (tonic seizure) was significantly increased by 80% or 69% when trifluoperazine (TFP) or chlorpromazine (CHP), a specific calmodulin inhibitor was preinjected intracerebroventricularly (i.v.t.)	Cyanides	18-25	calmodulin 2	Mus musculus	187-197
8427023-4	1993	Since it is known that the inhibitory effect of TFP or CHP against calmodulin-dependent enzymes such as phosphodiesterase is 100-400-fold higher compared to PMZ, it is speculated that the inhibitory effect of TFP or CHP against cyanide-induced convulsions may be based on its strong inhibitory properties into calmodulin-dependent enzymes.	Cyanides	228-235	calmodulin 2	Mus musculus	67-77
8427023-1	1993	The ED50 value of cyanide as measured by induction of convulsions (tonic seizure) was significantly increased by 80% or 69% when trifluoperazine (TFP) or chlorpromazine (CHP), a specific calmodulin inhibitor was preinjected intracerebroventricularly (i.v.t.)	Trifluoperazine	129-144	calmodulin 2	Mus musculus	187-197
1394118-5	1992	The calmodulin antagonist cyclosporine A, which does not suppress PKC activity, very effectively inhibits the TPA-induced edema and down regulation of PKC.	Cyclosporine	26-40	calmodulin 2	Mus musculus	4-14
1336364-3	1992	Treatment of AtT20 D16:16 cells with the synthetic glucocorticoid dexamethasone markedly (up to 10-fold) increased the level of a single (approximately 1.6kb) calmodulin mRNA 90 min after the application of steroid.	Dexamethasone	66-79	calmodulin 2	Mus musculus	159-169
1336364-3	1992	Treatment of AtT20 D16:16 cells with the synthetic glucocorticoid dexamethasone markedly (up to 10-fold) increased the level of a single (approximately 1.6kb) calmodulin mRNA 90 min after the application of steroid.	Steroids	207-214	calmodulin 2	Mus musculus	159-169
1336364-4	1992	Puromycin applied 15 min before and during dexamethasone treatment blocked the induction of this mRNA, suggesting that additional glucocorticoid induced transcription factor proteins may be required for enhanced calmodulin gene transcription.	Puromycin	0-9	calmodulin 2	Mus musculus	212-222
1336364-4	1992	Puromycin applied 15 min before and during dexamethasone treatment blocked the induction of this mRNA, suggesting that additional glucocorticoid induced transcription factor proteins may be required for enhanced calmodulin gene transcription.	Dexamethasone	43-56	calmodulin 2	Mus musculus	212-222
1336364-5	1992	A two-fold increase in the intensity of an approximately 18K immunoreactive calmodulin protein band was detected by immunoblotting at 90 min after dexamethasone administration.	Dexamethasone	147-160	calmodulin 2	Mus musculus	76-86
1336364-6	1992	Corticotropin releasing factor, added for 30 min at the start of steroid treatment, prevented the increase of calmodulin mRNA, as well as the suppression of corticotropin releasing factor-evoked ACTH release caused by dexamethasone.	Steroids	65-72	calmodulin 2	Mus musculus	110-120
21584609-6	1992	The parental cells treated with trazodone exhibited an increased accumulation of intracellular ADR, but lacked detectable alterations in the expression and drug-binding activity of plasma membrane P-glycoprotein, and trazodone did not affect the activities of isolated protein kinase C and calmodulin.	Trazodone	32-41	calmodulin 2	Mus musculus	290-300
1337998-5	1992	Many of the cellular responses to calcium are mediated through calmodulin.	Calcium	34-41	calmodulin 2	Mus musculus	63-73
1394118-5	1992	The calmodulin antagonist cyclosporine A, which does not suppress PKC activity, very effectively inhibits the TPA-induced edema and down regulation of PKC.	Tetradecanoylphorbol Acetate	110-113	calmodulin 2	Mus musculus	4-14
1484367-11	1992	Another means of increasing SR Ca2+ cycling was to partially remove the calmodulin-dependent control of SR Ca2+ release using the calmodulin inhibitor W-7.	W 7	151-154	calmodulin 2	Mus musculus	72-82
1484367-11	1992	Another means of increasing SR Ca2+ cycling was to partially remove the calmodulin-dependent control of SR Ca2+ release using the calmodulin inhibitor W-7.	W 7	151-154	calmodulin 2	Mus musculus	130-140
1371447-6	1992	Parallel perifusions of normal and transgenic islets confirmed that excess calmodulin inhibited glucose-stimulated insulin secretion; first phase secretion was reduced by 60%, and second phase secretion was essentially absent.	Glucose	96-103	calmodulin 2	Mus musculus	75-85
1360291-0	1992	Relationship between brain serotonin and calmodulin in young, genetically obese (ob/ob) mice.	Serotonin	27-36	calmodulin 2	Mus musculus	41-51
1360291-6	1992	Regardless of age and sex, brain serotonin was positively correlated to the brain calmodulin in the lean mice (r = 0.559, p < 0.01), yet this was not found in obese mice.	Serotonin	33-42	calmodulin 2	Mus musculus	82-92
1360291-9	1992	The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity.	Serotonin	45-54	calmodulin 2	Mus musculus	93-103
1360291-9	1992	The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity.	Calcium	149-156	calmodulin 2	Mus musculus	93-103
1360291-9	1992	The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity.	Serotonin	193-202	calmodulin 2	Mus musculus	93-103
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	calmidazolium	41-54	calmodulin 2	Mus musculus	18-28
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	calmidazolium	56-60	calmodulin 2	Mus musculus	18-28
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	W 7	63-114	calmodulin 2	Mus musculus	18-28
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	3-azido-2,7-naphthalene disulfonate	122-125	calmodulin 2	Mus musculus	18-28
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	Trifluoperazine	126-141	calmodulin 2	Mus musculus	18-28
1558157-2	1992	We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7.	Trifluoperazine	143-146	calmodulin 2	Mus musculus	18-28
1917967-4	1991	Steady state levels of CaM mRNA were increased up to 10-fold following a 4-6-h exposure of WEHI7.2 cells to 10(-6) M dexamethasone.	Dexamethasone	117-130	calmodulin 2	Mus musculus	23-26
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Cyclic AMP	27-31	calmodulin 2	Mus musculus	145-155
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Cyclic AMP	27-31	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Cyclic AMP	27-31	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Cyclic AMP	27-31	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Tamoxifen	84-93	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Tamoxifen	84-93	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Tamoxifen	84-93	calmodulin 2	Mus musculus	313-323
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Cyclic AMP	231-235	calmodulin 2	Mus musculus	145-155
1314079-7	1992	The opposite regulation of cAMP levels in the quail oviduct and the mouse uterus by tamoxifen reflected large differences in the contribution of calmodulin-dependent and -independent forms of phosphodiesterase to the hydrolysis of cAMP in the two models and the fact that tamoxifen stimulated the activity of the calmodulin-independent isoenzyme, while it competitively inhibited the activation of the calmodulin-dependent isoenzyme by calmodulin.	Tamoxifen	272-281	calmodulin 2	Mus musculus	145-155
1306503-4	1992	Trifluoperazine, a calmodulin antagonist, strongly inhibited the Ca(2+)-dependent DNA synthesis in the embryos.	Trifluoperazine	0-15	calmodulin 2	Mus musculus	19-29
1747759-0	1991	Melatonin modifies calmodulin cell levels in MDCK and N1E-115 cell lines and inhibits phosphodiesterase activity in vitro.	Melatonin	0-9	calmodulin 2	Mus musculus	19-29
1714727-0	1991	Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.	Arginine	161-169	calmodulin 2	Mus musculus	121-131
1714727-11	1991	Whereas constitutive NO synthase was potently inhibited by the calmodulin antagonists mellitin and trifluoperazine, cytokine-induced NO synthase was unaffected.	Trifluoperazine	99-114	calmodulin 2	Mus musculus	63-73
1714727-12	1991	In summary, NO synthesis by cytokine-activated MBE is THB-dependent, calmodulin-independent and inhibited by NG-substituted arginine analogs with a rank-order profile distinct from that for untreated endothelial cells but identical to that for cytokine-activated macrophages.	Nitroglycerin	109-111	calmodulin 2	Mus musculus	69-79
1747759-2	1991	Calmodulin cell levels in MDCK and N1E-115 cells cultured with 10(-9) M melatonin were increased after 3 days but decreased after 6 days.	Melatonin	72-81	calmodulin 2	Mus musculus	0-10
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	0-9	calmodulin 2	Mus musculus	20-30
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	75-84	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	75-84	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	75-84	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Tritium	89-91	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Tritium	89-91	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Tritium	89-91	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	92-101	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	92-101	calmodulin 2	Mus musculus	124-134
1747759-3	1991	Melatonin inhibited calmodulin-dependent phosphodiesterase and when either melatonin or [3H]melatonin was preincubated with calmodulin and separated by electrophoresis, comigration of calmodulin with the radioactivity as well as modification of the Ca2+ calmodulin shift were observed.	Melatonin	92-101	calmodulin 2	Mus musculus	124-134
1747759-4	1991	The results point out that one of the mechanisms of action of melatonin is a calmodulin-melatonin interaction.	Melatonin	62-71	calmodulin 2	Mus musculus	77-87
1747759-4	1991	The results point out that one of the mechanisms of action of melatonin is a calmodulin-melatonin interaction.	Melatonin	88-97	calmodulin 2	Mus musculus	77-87
1674871-0	1991	Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.	Trifluoperazine	35-50	calmodulin 2	Mus musculus	14-24
1674871-0	1991	Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.	Doxorubicin	197-208	calmodulin 2	Mus musculus	14-24
1965307-2	1990	In view of evidence for the involvement of calmodulin and microfilaments in the regulation of cholesterol transport and hence steroidogenesis, it is likely that this kinase is important in this process.	Cholesterol	94-105	calmodulin 2	Mus musculus	43-53
1828073-3	1991	Neuromodulin is phosphorylated by protein kinase C, and this phosphorylation prevents calmodulin from binding to neuromodulin (Alexander, K. A., Cimler, B. M., Meier, K. E. & Storm, D. R. (1987) J. Biol.	Adenosine Monophosphate	174-177	calmodulin 2	Mus musculus	86-96
2030001-10	1991	Calmodulin inhibitors trifluoperazine (100 mumol/L) and promethazine (100 mumol/L) inhibited the hyperpolarization of hepatocyte transmembrane potential caused by hyposmolality, as did 3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl ester) (50 mumol/L), which inhibits mobilization of Ca2+ from intracellular stores.	Trifluoperazine	22-37	calmodulin 2	Mus musculus	0-10
2030001-10	1991	Calmodulin inhibitors trifluoperazine (100 mumol/L) and promethazine (100 mumol/L) inhibited the hyperpolarization of hepatocyte transmembrane potential caused by hyposmolality, as did 3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl ester) (50 mumol/L), which inhibits mobilization of Ca2+ from intracellular stores.	Promethazine	56-68	calmodulin 2	Mus musculus	0-10
2030001-10	1991	Calmodulin inhibitors trifluoperazine (100 mumol/L) and promethazine (100 mumol/L) inhibited the hyperpolarization of hepatocyte transmembrane potential caused by hyposmolality, as did 3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl ester) (50 mumol/L), which inhibits mobilization of Ca2+ from intracellular stores.	3,4,5-trimethoxybenzoate 8-(n,n-diethylamino)octyl ester)	185-242	calmodulin 2	Mus musculus	0-10
1649984-0	1991	The naphthalenesulphonamide calmodulin antagonist W7 and its 5-iodo-1-C8 analogue inhibit potassium and calcium currents in NG108-15 neuroblastoma x glioma cells in a manner possibly unrelated to their antagonism of calmodulin.	naphthalenesulphonamide	4-27	calmodulin 2	Mus musculus	28-38
1649984-0	1991	The naphthalenesulphonamide calmodulin antagonist W7 and its 5-iodo-1-C8 analogue inhibit potassium and calcium currents in NG108-15 neuroblastoma x glioma cells in a manner possibly unrelated to their antagonism of calmodulin.	Potassium	90-99	calmodulin 2	Mus musculus	28-38
1649984-0	1991	The naphthalenesulphonamide calmodulin antagonist W7 and its 5-iodo-1-C8 analogue inhibit potassium and calcium currents in NG108-15 neuroblastoma x glioma cells in a manner possibly unrelated to their antagonism of calmodulin.	Calcium	104-111	calmodulin 2	Mus musculus	28-38
1649984-2	1991	N-(6-aminohexyl)-5-chloro-1-naphthalene- sulphonamide (W7), a calmodulin (CaM) antagonist and its more potent (10 times) 5-iodo-1-C8 analogue (J8) inhibited these currents in a dose-dependent manner.	n-(6-aminohexyl)-5-chloro-1-naphthalene- sulphonamide	0-53	calmodulin 2	Mus musculus	62-72
1649984-2	1991	N-(6-aminohexyl)-5-chloro-1-naphthalene- sulphonamide (W7), a calmodulin (CaM) antagonist and its more potent (10 times) 5-iodo-1-C8 analogue (J8) inhibited these currents in a dose-dependent manner.	n-(6-aminohexyl)-5-chloro-1-naphthalene- sulphonamide	0-53	calmodulin 2	Mus musculus	74-77
1905264-6	1991	Chlorpromazine, which has an antagonistic action towards calmodulin, also suppressed the increases of calcium and ALP in the tooth germ.	Chlorpromazine	0-14	calmodulin 2	Mus musculus	57-67
1905264-6	1991	Chlorpromazine, which has an antagonistic action towards calmodulin, also suppressed the increases of calcium and ALP in the tooth germ.	Calcium	102-109	calmodulin 2	Mus musculus	57-67
2058478-0	1991	Influence of the intracellular free calcium level and calmodulin antagonists on prostaglandin and leukotriene synthesis in murine macrophages.	Prostaglandins	80-93	calmodulin 2	Mus musculus	54-64
2058478-0	1991	Influence of the intracellular free calcium level and calmodulin antagonists on prostaglandin and leukotriene synthesis in murine macrophages.	Leukotrienes	98-109	calmodulin 2	Mus musculus	54-64
2018358-0	1991	Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma.	W 7	58-108	calmodulin 2	Mus musculus	35-45
2018358-1	1991	The antimetastatic effect of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was examined in an experimental model of lung metastasis induced by Lewis lung carcinomas (3LL) in C57BL/6crSlc mice.	W 7	52-102	calmodulin 2	Mus musculus	29-39
2018358-1	1991	The antimetastatic effect of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was examined in an experimental model of lung metastasis induced by Lewis lung carcinomas (3LL) in C57BL/6crSlc mice.	W 7	104-107	calmodulin 2	Mus musculus	29-39
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	Trifluoperazine	32-47	calmodulin 2	Mus musculus	20-30
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	Trifluoperazine	32-47	calmodulin 2	Mus musculus	102-112
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	Pimozide	49-57	calmodulin 2	Mus musculus	20-30
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	Pimozide	49-57	calmodulin 2	Mus musculus	102-112
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	W 7	62-65	calmodulin 2	Mus musculus	20-30
1965307-4	1990	Three inhibitors of calmodulin (trifluoperazine, pimozide and W-7) inhibit steroidogenesis and Ca2(+)-calmodulin-dependent phosphorylation kinase activity with similar values for EC50 for the two processes.	W 7	62-65	calmodulin 2	Mus musculus	102-112
1965307-7	1990	Calmodulin-binding proteins analyzed by [125I]iodocalmodulin overlay and calmodulin-Sepharose affinity chromatography were also identified in the same cytoskeletons including alpha-spectrin, the Ca2+ calmodulin-dependent phosphatase calcineurin and three that were tentatively identified as the two subunits of the kinase itself and myosin light chain kinase.	Sepharose	84-93	calmodulin 2	Mus musculus	0-10
1965307-7	1990	Calmodulin-binding proteins analyzed by [125I]iodocalmodulin overlay and calmodulin-Sepharose affinity chromatography were also identified in the same cytoskeletons including alpha-spectrin, the Ca2+ calmodulin-dependent phosphatase calcineurin and three that were tentatively identified as the two subunits of the kinase itself and myosin light chain kinase.	Sepharose	84-93	calmodulin 2	Mus musculus	73-83
2222519-0	1990	Modulation of doxorubicin-induced chromosomal damage by calmodulin inhibitors and its relationship to cytotoxicity in progressively doxorubicin-resistant tumor cells.	Doxorubicin	14-25	calmodulin 2	Mus musculus	56-66
2208115-0	1990	Increased sensitivity to Vinca alkaloids in cells overexpressing calmodulin by gene transfection.	Vinca Alkaloids	25-40	calmodulin 2	Mus musculus	65-75
2208115-11	1990	These data suggest that the increase in CaM expression in the C2 and C3 cell lines might be related to the higher sensitivity of these cells to Vinca alkaloids.	Vinca Alkaloids	144-159	calmodulin 2	Mus musculus	40-43
2222519-1	1990	Modulation of doxorubicin (DOX) cytotoxicity by the calmodulin inhibitor trifluoperazine (TFP) in progressively doxorubicin-resistant L1210 mouse leukemia cells is unrelated to effects on drug accumulation.	Trifluoperazine	73-88	calmodulin 2	Mus musculus	52-62
2222519-3	1990	Potentiation of DOX cytotoxicity by CGS9343B (a potent inhibitor of calmodulin which does not inhibit protein kinase C) was related to the level of resistance.	Doxorubicin	16-19	calmodulin 2	Mus musculus	68-78
2222519-3	1990	Potentiation of DOX cytotoxicity by CGS9343B (a potent inhibitor of calmodulin which does not inhibit protein kinase C) was related to the level of resistance.	CGS 9343B	36-44	calmodulin 2	Mus musculus	68-78
2222519-5	1990	Exposure to calmodulin inhibitors following DOX treatment enhanced chromosomal aberrations and cytotoxicity.	Doxorubicin	44-47	calmodulin 2	Mus musculus	12-22
2222519-6	1990	Maximal effects of calmodulin inhibitors were apparent when used during and after DOX treatment, and potentiation of cytotoxicity was related to modulation of DOX-induced chromosomal aberrations.	Doxorubicin	82-85	calmodulin 2	Mus musculus	19-29
2222519-7	1990	Results suggest that inhibition of calmodulin-regulated processes is a potential target in the modulation of DNA damage/repair, and could play a pivotal role in the expression of "acquired resistance" to DOX.	Doxorubicin	204-207	calmodulin 2	Mus musculus	35-45
2222519-0	1990	Modulation of doxorubicin-induced chromosomal damage by calmodulin inhibitors and its relationship to cytotoxicity in progressively doxorubicin-resistant tumor cells.	Doxorubicin	132-143	calmodulin 2	Mus musculus	56-66
2222519-1	1990	Modulation of doxorubicin (DOX) cytotoxicity by the calmodulin inhibitor trifluoperazine (TFP) in progressively doxorubicin-resistant L1210 mouse leukemia cells is unrelated to effects on drug accumulation.	Doxorubicin	14-25	calmodulin 2	Mus musculus	52-62
2222519-1	1990	Modulation of doxorubicin (DOX) cytotoxicity by the calmodulin inhibitor trifluoperazine (TFP) in progressively doxorubicin-resistant L1210 mouse leukemia cells is unrelated to effects on drug accumulation.	Doxorubicin	27-30	calmodulin 2	Mus musculus	52-62
1965387-0	1990	[The effect of db-cAMP on the gene expression of calmodulin and cytoskeleton in the transformed cells].	Bucladesine	15-22	calmodulin 2	Mus musculus	49-59
1965387-8	1990	It is suggested that the inhibition of proliferation, alteration of phenotype and recovery of cytoskeleton in transformed cells after treatment with db-cAMP are related to the inhibition of gene expression of calmodulin.	Bucladesine	149-156	calmodulin 2	Mus musculus	209-219
2115792-0	1990	Regulation of mouse preimplantation development: inhibitory effect of the calmodulin antagonist W-7 on the first cleavage.	W 7	96-99	calmodulin 2	Mus musculus	74-84
2109010-0	1990	Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.	Tetradecanoylphorbol Acetate	0-25	calmodulin 2	Mus musculus	73-83
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	242-292	calmodulin 2	Mus musculus	71-81
2370855-11	1990	The enzyme(s) showed very little activity in the presence of L-arginine (100 microM) and NADPH (100 microM), but the activity could be fully restored by addition of exogenous calmodulin (EC50, approximately 2 units/ml).	Arginine	61-71	calmodulin 2	Mus musculus	175-185
2370855-11	1990	The enzyme(s) showed very little activity in the presence of L-arginine (100 microM) and NADPH (100 microM), but the activity could be fully restored by addition of exogenous calmodulin (EC50, approximately 2 units/ml).	NADP	89-94	calmodulin 2	Mus musculus	175-185
2370855-0	1990	Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.	Nitric Oxide	68-80	calmodulin 2	Mus musculus	147-157
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	calmidazolium	159-172	calmodulin 2	Mus musculus	71-81
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	Trifluoperazine	185-200	calmodulin 2	Mus musculus	71-81
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	Fendiline	214-223	calmodulin 2	Mus musculus	71-81
2370855-8	1990	The synthesis of EDRF/NO was inhibited by the following antagonists of calmodulin-regulated functions (with the approximate IC50 values given in parentheses): calmidazolium (7 microM), trifluoperazine (10 microM), fendiline (80 microM), W-7 (N-[6-aminohexyl]-5-chloro-1-naphthalenesulfonamide) (120 microM), and compound 48/80 (3 micrograms/ml).	W 7	237-240	calmodulin 2	Mus musculus	71-81
2158426-2	1990	In whole cells it was found that two responses (production of steroids and cAMP) to two stimulating agents (ACTH and forskolin) were inhibited by trifluoperazine at concentrations consistent with those involved in binding of the inhibitor to pure calmodulin (10-25 microM).	Colforsin	117-126	calmodulin 2	Mus musculus	247-257
2158426-2	1990	In whole cells it was found that two responses (production of steroids and cAMP) to two stimulating agents (ACTH and forskolin) were inhibited by trifluoperazine at concentrations consistent with those involved in binding of the inhibitor to pure calmodulin (10-25 microM).	Trifluoperazine	146-161	calmodulin 2	Mus musculus	247-257
2158426-3	1990	The steroidogenic responses were also inhibited by the three other inhibitors of calmodulin (chlorpromazine, calmidazolium, and W-7).	Chlorpromazine	93-107	calmodulin 2	Mus musculus	81-91
2158426-3	1990	The steroidogenic responses were also inhibited by the three other inhibitors of calmodulin (chlorpromazine, calmidazolium, and W-7).	calmidazolium	109-122	calmodulin 2	Mus musculus	81-91
2158426-3	1990	The steroidogenic responses were also inhibited by the three other inhibitors of calmodulin (chlorpromazine, calmidazolium, and W-7).	W 7	128-131	calmodulin 2	Mus musculus	81-91
2158426-5	1990	With Y-1 plasma membranes it was found that trifluoperazine, pimozide, W-7, and calmodulin antibodies inhibited the increase in adenylate cyclase activity in response to ACTH, but not the cyclase responses to cholera toxin or forskolin.	Colforsin	226-235	calmodulin 2	Mus musculus	80-90
2297765-3	1990	We compared the responsiveness of multidrug-resistant cells to the effect of dequalinium with that to trifluoperazine, a potent phenothiazine inhibitor of calmodulin.	Trifluoperazine	102-117	calmodulin 2	Mus musculus	155-165
2106445-4	1990	The c-fos mRNA and protein induction in mouse neurons was prevented by the noncompetitive NMDA antagonist ketamine but only partially inhibited by the voltage-dependent calcium channel antagonist nifedipine and the calmodulin antagonist trifluoperazine.	Trifluoperazine	237-252	calmodulin 2	Mus musculus	215-225
2182648-1	1990	The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues.	Calcium	163-170	calmodulin 2	Mus musculus	36-39
2182648-1	1990	The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues.	Calcium	163-170	calmodulin 2	Mus musculus	86-89
2182648-6	1990	Adhesion mediated by either CAM was inhibited by treatment with cytochalasin D that disrupted the actin network of the transfected cells.	Cytochalasin D	64-78	calmodulin 2	Mus musculus	28-31
2297765-3	1990	We compared the responsiveness of multidrug-resistant cells to the effect of dequalinium with that to trifluoperazine, a potent phenothiazine inhibitor of calmodulin.	phenothiazine	128-141	calmodulin 2	Mus musculus	155-165
2297765-9	1990	Calmodulin prepared from resistant cells were equally sensitive to inhibition by dequalinium and trifluoperazine.	Dequalinium	81-92	calmodulin 2	Mus musculus	0-10
2297765-9	1990	Calmodulin prepared from resistant cells were equally sensitive to inhibition by dequalinium and trifluoperazine.	Trifluoperazine	97-112	calmodulin 2	Mus musculus	0-10
2350237-0	1990	A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system.	Cadmium	15-22	calmodulin 2	Mus musculus	81-91
2350237-0	1990	A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system.	Calcium	54-61	calmodulin 2	Mus musculus	81-91
2350237-0	1990	A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system.	Cadmium	66-73	calmodulin 2	Mus musculus	81-91
2350237-5	1990	Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism.	Cadmium	151-158	calmodulin 2	Mus musculus	278-288
2350237-5	1990	Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism.	Cadmium	151-158	calmodulin 2	Mus musculus	278-288
2350237-5	1990	Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism.	Catecholamines	209-222	calmodulin 2	Mus musculus	278-288
34339735-4	2021	To investigate whether acetylation of non-histone proteins is important for synaptic plasticity, we analyzed mouse brain acetylome and found that calmodulin (CaM), a ubiquitous Ca2+ sensor, was acetylated on three lysine residues which were conserved across species.	Lysine	214-220	calmodulin 2	Mus musculus	146-156
34391760-4	2021	Here, we present evidence that the loss-of-CaMKII function correlates with premature phosphorylation of its inhibitory phosphosite T306 in CaMKIIalpha and T307 in CaMKIIdelta as this site was up to 20-fold more phosphorylated in the presence of D130G CaM compared to wildtype CaM.	phosphosite	119-130	calmodulin 2	Mus musculus	251-254
34391760-4	2021	Here, we present evidence that the loss-of-CaMKII function correlates with premature phosphorylation of its inhibitory phosphosite T306 in CaMKIIalpha and T307 in CaMKIIdelta as this site was up to 20-fold more phosphorylated in the presence of D130G CaM compared to wildtype CaM.	t306	131-135	calmodulin 2	Mus musculus	251-254
34411733-9	2021	This phenotype was associated with impaired calcium-dependent vasoconstriction and altered expression of calcium-sensitive proteins including SERCA and calmodulin.	Calcium	105-112	calmodulin 2	Mus musculus	152-162
2272659-5	1990	A consensus splice donor site which is conserved in human, baboon, and mouse mRNAs that encode a molecule with an elongated cytoplasmic domain (H-CAM-L) is utilized to generate a distinct but low-abundance mRNA species that encodes H-CAM(CD44) with a truncated cytoplasmic domain of only three amino acids (H-CAM-S).	Sulfur	313-314	calmodulin 2	Mus musculus	234-237
33766558-10	2021	The cell-permeable calmodulin antagonist CGS9343B significantly reduced activation of ERK by EGF in mouse embryo fibroblasts that overexpress KSR1, but not in control cells.	CGS 9343B	41-49	calmodulin 2	Mus musculus	19-29
34339735-4	2021	To investigate whether acetylation of non-histone proteins is important for synaptic plasticity, we analyzed mouse brain acetylome and found that calmodulin (CaM), a ubiquitous Ca2+ sensor, was acetylated on three lysine residues which were conserved across species.	Lysine	214-220	calmodulin 2	Mus musculus	158-161
34859931-10	2022	Moreover, calmodulin (CaM) interacted with CSE in VSMCs; HG increased intracellular Ca2+ concentration and induced CaM expression, further strengthened the interaction of CaM with CSE in VSMCs, which were further enhanced by SKF38393.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	225-233	calmodulin 2	Mus musculus	10-20
35271288-0	2022	Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.	Pyrimidinones	18-30	calmodulin 2	Mus musculus	71-81
35201398-2	2022	In interaction with calmodulin (CaM), it indirectly modulates the activity of dihydropyridine and ryanodine Ca2+ channels.	1,4-dihydropyridine	78-93	calmodulin 2	Mus musculus	20-30
35201398-2	2022	In interaction with calmodulin (CaM), it indirectly modulates the activity of dihydropyridine and ryanodine Ca2+ channels.	1,4-dihydropyridine	78-93	calmodulin 2	Mus musculus	32-35
35201398-2	2022	In interaction with calmodulin (CaM), it indirectly modulates the activity of dihydropyridine and ryanodine Ca2+ channels.	Ryanodine	98-107	calmodulin 2	Mus musculus	20-30
35201398-2	2022	In interaction with calmodulin (CaM), it indirectly modulates the activity of dihydropyridine and ryanodine Ca2+ channels.	Ryanodine	98-107	calmodulin 2	Mus musculus	32-35
34859931-10	2022	Moreover, calmodulin (CaM) interacted with CSE in VSMCs; HG increased intracellular Ca2+ concentration and induced CaM expression, further strengthened the interaction of CaM with CSE in VSMCs, which were further enhanced by SKF38393.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	225-233	calmodulin 2	Mus musculus	22-25
34859931-10	2022	Moreover, calmodulin (CaM) interacted with CSE in VSMCs; HG increased intracellular Ca2+ concentration and induced CaM expression, further strengthened the interaction of CaM with CSE in VSMCs, which were further enhanced by SKF38393.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	225-233	calmodulin 2	Mus musculus	171-174
34859931-11	2022	CaM inhibitor W-7, inositol 1,4,5-trisphosphate (IP3 ) inhibitor 2-APB, or ryanodine receptor inhibitor tetracaine abolished the stimulatory effect of SKF38393 on CaM expression and intracellular Ca2+ concentration.	Inositol 1,4,5-Trisphosphate	19-47	calmodulin 2	Mus musculus	163-166
34859931-11	2022	CaM inhibitor W-7, inositol 1,4,5-trisphosphate (IP3 ) inhibitor 2-APB, or ryanodine receptor inhibitor tetracaine abolished the stimulatory effect of SKF38393 on CaM expression and intracellular Ca2+ concentration.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	151-159	calmodulin 2	Mus musculus	0-3
34859931-11	2022	CaM inhibitor W-7, inositol 1,4,5-trisphosphate (IP3 ) inhibitor 2-APB, or ryanodine receptor inhibitor tetracaine abolished the stimulatory effect of SKF38393 on CaM expression and intracellular Ca2+ concentration.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	151-159	calmodulin 2	Mus musculus	163-166
34859931-12	2022	Taken together, these results suggest that DR1 up-regulates CSE/H2 S signaling by inducing the Ca2+ -CaM pathway followed by down-regulations of IGF-1-IGF-1R and HB-EGF-EGFR and their downstream ERK1/2 and PI3K-Akt, finally promoting the apoptosis of VSMCs in diabetic mice.	Deuterium	64-66	calmodulin 2	Mus musculus	101-104
35154484-16	2022	GaELN PA binds to BASP1, leading to inhibition of c-Myc expression and activity through competitively binding to CaM with c-Myc transcription factor.	Phosphatidic Acids	6-8	calmodulin 2	Mus musculus	113-116
2795459-0	1989	Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea.	cysteinylglycine	28-31	calmodulin 2	Mus musculus	6-16
2625618-1	1989	The purpose of this study was to characterize by immunofluorescent microscopy, the cytoskeletal proteins actin and myosin and the protein calmodulin (CaM) in trephined, n-heptanol treated murine corneal epithelium during in vitro organ culture before and following topical ocular anesthetic application.	Heptanol	169-179	calmodulin 2	Mus musculus	138-148
2625618-1	1989	The purpose of this study was to characterize by immunofluorescent microscopy, the cytoskeletal proteins actin and myosin and the protein calmodulin (CaM) in trephined, n-heptanol treated murine corneal epithelium during in vitro organ culture before and following topical ocular anesthetic application.	Heptanol	169-179	calmodulin 2	Mus musculus	150-153
2795459-0	1989	Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea.	9343b	32-37	calmodulin 2	Mus musculus	6-16
2795459-2	1989	Calmodulin is an important intermediate in the mucosal signal-transduction pathways that regulate intestinal NaCl transport.	Sodium Chloride	109-113	calmodulin 2	Mus musculus	0-10
2795459-3	1989	We tested a selective inhibitor of calmodulin, CGS 9343B, for antidiarrheal activity in two different models of secretory diarrhea.	cysteinylglycine	47-50	calmodulin 2	Mus musculus	35-45
2795459-3	1989	We tested a selective inhibitor of calmodulin, CGS 9343B, for antidiarrheal activity in two different models of secretory diarrhea.	9343b	51-56	calmodulin 2	Mus musculus	35-45
2718179-11	1989	These in situ Ca:Pb relationships should be useful for designing and evaluating Ca-Pb studies with calmodulin, isolated mitochondria, and other individual components of the calcium messenger system.	Lead	17-19	calmodulin 2	Mus musculus	99-109
2673540-1	1989	Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations.	Calcium	58-65	calmodulin 2	Mus musculus	0-10
2551780-4	1989	A three-component cloning procedure in which a gene product requiring CaM for activity, adenylate cyclase from the pathogen Bordetella pertussis, was used to screen a cDNA library for cAMP synthesis in E. coli.	Cyclic AMP	184-188	calmodulin 2	Mus musculus	70-73
2561511-4	1989	The delayed effect of alpha-CAO in development of habituation was accompanied by increase of AC activity and cAMP content of the brain, calmodulin content in the brain.	7-(N,N-bis(2-chloroethyl)amino)-6,14-endoethenotetrahydrooripavine	22-31	calmodulin 2	Mus musculus	136-146
2546743-0	1989	The role of Ca2+ and calmodulin in the regulation of atrial natriuretic peptide-stimulated guanosine 3",5"-cyclic monophosphate accumulation by isolated mouse Leydig cells.	Cyclic GMP	91-127	calmodulin 2	Mus musculus	21-31
2546743-1	1989	We have investigated the role of Ca2+ and calmodulin in the stimulation of cGMP formation by mouse Leydig cells in response to rat atriopeptin-II (rAP-II).	Cyclic GMP	75-79	calmodulin 2	Mus musculus	42-52
2546743-9	1989	Furthermore, three structurally unrelated calmodulin antagonists, W7, trifluoperazine, and calmidazolium, but not W5, caused a dose-related inhibition of rAP-II-stimulated cGMP accumulation by the cells.	Trifluoperazine	70-85	calmodulin 2	Mus musculus	42-52
2546743-9	1989	Furthermore, three structurally unrelated calmodulin antagonists, W7, trifluoperazine, and calmidazolium, but not W5, caused a dose-related inhibition of rAP-II-stimulated cGMP accumulation by the cells.	calmidazolium	91-104	calmodulin 2	Mus musculus	42-52
2546743-9	1989	Furthermore, three structurally unrelated calmodulin antagonists, W7, trifluoperazine, and calmidazolium, but not W5, caused a dose-related inhibition of rAP-II-stimulated cGMP accumulation by the cells.	Cyclic GMP	172-176	calmodulin 2	Mus musculus	42-52
2720644-8	1989	We concluded that nifedipine interacts with specific target site(s) which are not accessible by verapamil, by diltiazem, or by the calmodulin antagonists.	Nifedipine	18-28	calmodulin 2	Mus musculus	131-141
2747661-9	1989	In addition, the results suggest that calcium regulates progression through mitosis by both calmodulin-dependent (metaphase transition) and -independent (prophase) mechanisms.	Calcium	38-45	calmodulin 2	Mus musculus	92-102
2783423-4	1989	Exposure of T cells to ionomycin leads to an abrupt increase in [Ca]i followed by stabilization at a dose-dependent plateau level that is affected by extracellular EGTA, by calmodulin inhibitors, and by modulators of protein kinase C. Plateau levels of [Ca]i after ionomycin challenge were consistently lower in T cells from old mice than in T cells from young mice.	Ionomycin	23-32	calmodulin 2	Mus musculus	173-183
3183602-1	1988	Involvement of calmodulin-dependent processes in preimplantation development of mouse embryos was studied with the use of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a specific antagonist of calmodulin.	W 7	174-177	calmodulin 2	Mus musculus	15-25
2847548-0	1988	AVP-sensitive cAMP production is dependent on calmodulin in both MTAL and MCT.	Cyclic AMP	14-18	calmodulin 2	Mus musculus	46-56
2847548-6	1988	The inhibitory effect of W-5, a chemically similar to W-7 but less potent calmodulin inhibitor, was significantly less than that of W-7 in both nephron segments.	N-(6-aminohexyl)-1-naphthalenesulfonamide	25-28	calmodulin 2	Mus musculus	74-84
2844815-1	1988	A distinct high affinity cAMP isoenzyme immunologically related to brain calmodulin-dependent cGMP phosphodiesterase.	Cyclic AMP	25-29	calmodulin 2	Mus musculus	73-83
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	Cyclic AMP	110-114	calmodulin 2	Mus musculus	27-37
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	Cyclic AMP	110-114	calmodulin 2	Mus musculus	39-42
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	Cyclic AMP	110-114	calmodulin 2	Mus musculus	229-232
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	2-diethylaminoethanol	163-167	calmodulin 2	Mus musculus	27-37
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	2-diethylaminoethanol	163-167	calmodulin 2	Mus musculus	39-42
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	Sepharose	233-242	calmodulin 2	Mus musculus	27-37
2844815-2	1988	A cell-specific isozyme of calmodulin (CaM)-dependent phosphodiesterase that exhibits micromolar affinity for cAMP has been purified 900-fold from mouse testis by DEAE chromatography, gel filtration, affinity chromatography with CaM-Sepharose 4B, and isoelectric focusing.	Sepharose	233-242	calmodulin 2	Mus musculus	39-42
2844815-3	1988	The highly purified enzyme is stimulated 5-6-fold by CaM in the presence of Ca2+ and hydrolyzes both cAMP and cGMP with anomalous substrate dependence, i.e. high and low affinity components (Km 2 and 20 microM) are observed either in the presence or absence of CaM.	Cyclic AMP	101-105	calmodulin 2	Mus musculus	53-56
2844815-3	1988	The highly purified enzyme is stimulated 5-6-fold by CaM in the presence of Ca2+ and hydrolyzes both cAMP and cGMP with anomalous substrate dependence, i.e. high and low affinity components (Km 2 and 20 microM) are observed either in the presence or absence of CaM.	Cyclic AMP	101-105	calmodulin 2	Mus musculus	261-264
2844815-3	1988	The highly purified enzyme is stimulated 5-6-fold by CaM in the presence of Ca2+ and hydrolyzes both cAMP and cGMP with anomalous substrate dependence, i.e. high and low affinity components (Km 2 and 20 microM) are observed either in the presence or absence of CaM.	Cyclic GMP	110-114	calmodulin 2	Mus musculus	53-56
2844815-3	1988	The highly purified enzyme is stimulated 5-6-fold by CaM in the presence of Ca2+ and hydrolyzes both cAMP and cGMP with anomalous substrate dependence, i.e. high and low affinity components (Km 2 and 20 microM) are observed either in the presence or absence of CaM.	Cyclic GMP	110-114	calmodulin 2	Mus musculus	261-264
2551918-2	1989	Calmodulin has been implicated as being involved in mediating the activity of a number of fundamental calcium-regulated intracellular enzyme systems including phosphodiesterases, adenylate cyclase, and a variety of kinases, all of which may regulate or be regulated by intracellular cAMP.	Cyclic AMP	283-287	calmodulin 2	Mus musculus	0-10
2460125-4	1988	Intracellular calmodulin was significantly higher in rapidly dividing keratinocytes in normal (1.15 mM) calcium medium than in slower dividing cells in low (0.15 mM) calcium.	calcium medium	104-118	calmodulin 2	Mus musculus	14-24
2460125-4	1988	Intracellular calmodulin was significantly higher in rapidly dividing keratinocytes in normal (1.15 mM) calcium medium than in slower dividing cells in low (0.15 mM) calcium.	Calcium	104-111	calmodulin 2	Mus musculus	14-24
3179186-1	1988	The role of the calmodulin inhibitor trifluoperazine (TFP) in modulating the cellular levels and cytotoxicity in vitro and antitumour effects in vivo of doxorubicin (DOX), was evaluated in progressively DOX-resistant (5- to 40-fold) sublines of B16-BL6 mouse melanoma.	Doxorubicin	166-169	calmodulin 2	Mus musculus	16-26
3277881-2	1988	Embryonic spectrin binds 125I-calmodulin in a calcium-dependent fashion in the blot overlay technique.	Calcium	46-53	calmodulin 2	Mus musculus	30-40
2839192-4	1988	Both subunits bound [125I]calmodulin in a calcium-dependent manner and demonstrated calmodulin-dependent autophosphorylation.	Calcium	42-49	calmodulin 2	Mus musculus	26-36
2839192-4	1988	Both subunits bound [125I]calmodulin in a calcium-dependent manner and demonstrated calmodulin-dependent autophosphorylation.	Calcium	42-49	calmodulin 2	Mus musculus	84-94
2839192-6	1988	The apparent Km values of the kinase for ATP and calmodulin were 17 microM and 55 nM respectively.	Adenosine Triphosphate	41-44	calmodulin 2	Mus musculus	49-59
3131462-1	1988	The effect of calmodulin antagonists (W-5 and W-7) on antitumor activity of 1-(2-Tetrahydrofuryl)-5-fluorouracil (Tegafur; FT) and FT plus uracil (UFT) was examined by using nude mice bearing human ovarian carcinoma (KF cells).	Tegafur	76-112	calmodulin 2	Mus musculus	14-24
3382648-3	1988	The permeability change in the growth medium was significantly enhanced by calmodulin-interacting drugs, such as trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and chlorpromazine (CPZ).	Trifluoperazine	113-128	calmodulin 2	Mus musculus	75-85
3382648-3	1988	The permeability change in the growth medium was significantly enhanced by calmodulin-interacting drugs, such as trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and chlorpromazine (CPZ).	Trifluoperazine	130-133	calmodulin 2	Mus musculus	75-85
3382648-3	1988	The permeability change in the growth medium was significantly enhanced by calmodulin-interacting drugs, such as trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and chlorpromazine (CPZ).	Chlorpromazine	196-210	calmodulin 2	Mus musculus	75-85
3382648-3	1988	The permeability change in the growth medium was significantly enhanced by calmodulin-interacting drugs, such as trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) and chlorpromazine (CPZ).	Chlorpromazine	212-215	calmodulin 2	Mus musculus	75-85
3133378-3	1988	A preferential positional shift toward the cathode was observed which was inhibited by the calcium channel blocker D-600 and the calmodulin antagonist trifluoperazine.	Trifluoperazine	151-166	calmodulin 2	Mus musculus	129-139
3133378-4	1988	Rhodaminephalloidin labeling of actin filaments revealed a field-induced disorganization of the stress fiber pattern, which was reduced when stimulation was conducted in calcium-depleted buffer or in buffer containing calcium antagonist CoCl2, calcium channel blocker D-600, or calmodulin antagonist trifluoperazine.	rhodamine-phalloidin	0-19	calmodulin 2	Mus musculus	278-288
2451030-1	1988	Phenothiazines and structurally related calmodulin antagonists acted synergistically with bleomycin in killing malignant cells in culture.	Bleomycin	90-99	calmodulin 2	Mus musculus	40-50
3180142-0	1988	Enhancement of antineoplastic effects of cisplatin by a calmodulin antagonist (W-7) in nude mice bearing human ovarian carcinoma.	Cisplatin	41-50	calmodulin 2	Mus musculus	56-66
2977964-2	1988	In this study, we further demonstrate that flunarizine and dehydroepiandrosterone, which are proved to interact with calmodulin, showed antitumor-promoting activity in two-stage carcinogenesis of mouse skin.	Flunarizine	43-54	calmodulin 2	Mus musculus	117-127
3342075-0	1988	Differential effect of the calmodulin inhibitor trifluoperazine in modulating cellular accumulation, retention and cytotoxicity of doxorubicin in progressively doxorubicin-resistant L1210 mouse leukemia cells.	Trifluoperazine	48-63	calmodulin 2	Mus musculus	27-37
3342075-0	1988	Differential effect of the calmodulin inhibitor trifluoperazine in modulating cellular accumulation, retention and cytotoxicity of doxorubicin in progressively doxorubicin-resistant L1210 mouse leukemia cells.	Doxorubicin	131-142	calmodulin 2	Mus musculus	27-37
3342075-2	1988	Calmodulin inhibitors are effective in enhancing cytotoxic effects of doxorubicin (DOX) in DOX-resistant cells, possibly by enhancing cellular levels of drug.	Doxorubicin	70-81	calmodulin 2	Mus musculus	0-10
3342075-2	1988	Calmodulin inhibitors are effective in enhancing cytotoxic effects of doxorubicin (DOX) in DOX-resistant cells, possibly by enhancing cellular levels of drug.	Doxorubicin	83-86	calmodulin 2	Mus musculus	0-10
3342075-2	1988	Calmodulin inhibitors are effective in enhancing cytotoxic effects of doxorubicin (DOX) in DOX-resistant cells, possibly by enhancing cellular levels of drug.	Doxorubicin	91-94	calmodulin 2	Mus musculus	0-10
2977964-2	1988	In this study, we further demonstrate that flunarizine and dehydroepiandrosterone, which are proved to interact with calmodulin, showed antitumor-promoting activity in two-stage carcinogenesis of mouse skin.	Dehydroepiandrosterone	59-81	calmodulin 2	Mus musculus	117-127
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	calmidazolium	27-40	calmodulin 2	Mus musculus	4-14
3351366-0	1988	[Potentiation of the antitumor effect of cisplatin by calmodulin antagonists (W-7 and W-5) in nude mice bearing human ovarian carcinoma].	Cisplatin	41-50	calmodulin 2	Mus musculus	54-64
3424382-7	1987	Trifluoperazine (100 microM), a drug which in vitro binds tightly to calmodulin, imitated the toxic effects of 10 microM cadmium acetate.	Trifluoperazine	0-15	calmodulin 2	Mus musculus	69-79
3424382-7	1987	Trifluoperazine (100 microM), a drug which in vitro binds tightly to calmodulin, imitated the toxic effects of 10 microM cadmium acetate.	cadmium acetate	121-136	calmodulin 2	Mus musculus	69-79
3424382-9	1987	A possible mechanism for the cadmium acetate-induced swelling and inhibition of ciliary activity could, thus, be a disturbance of the regulatory activity of calmodulin.	cadmium acetate	29-44	calmodulin 2	Mus musculus	157-167
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	W 7	129-180	calmodulin 2	Mus musculus	105-115
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	W 7	182-185	calmodulin 2	Mus musculus	105-115
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	N-(6-aminohexyl)-1-naphthalenesulfonamide	191-232	calmodulin 2	Mus musculus	105-115
3677086-1	1987	The present study was designed to potentiate the antineoplastic effects of cisplatin by combination with calmodulin antagonists [N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5)] in nude mice bearing human ovarian carcinoma.	N-(6-aminohexyl)-1-naphthalenesulfonamide	234-237	calmodulin 2	Mus musculus	105-115
3264274-4	1988	The increased cytotoxicity of splenocytes on treatment with cisplatin is reversed by the calcium channel blocker nifedipine and the calmodulin antagonist chlorpromazine, suggesting a role of calcium in cisplatin-activated lymphocyte-mediated cytotoxicity.	Cisplatin	60-69	calmodulin 2	Mus musculus	132-142
3264274-4	1988	The increased cytotoxicity of splenocytes on treatment with cisplatin is reversed by the calcium channel blocker nifedipine and the calmodulin antagonist chlorpromazine, suggesting a role of calcium in cisplatin-activated lymphocyte-mediated cytotoxicity.	Chlorpromazine	154-168	calmodulin 2	Mus musculus	132-142
3264274-4	1988	The increased cytotoxicity of splenocytes on treatment with cisplatin is reversed by the calcium channel blocker nifedipine and the calmodulin antagonist chlorpromazine, suggesting a role of calcium in cisplatin-activated lymphocyte-mediated cytotoxicity.	Cisplatin	202-211	calmodulin 2	Mus musculus	132-142
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	calmidazolium	27-40	calmodulin 2	Mus musculus	196-206
3124851-0	1987	Role of Ca2+/calmodulin in the regulation of sugar uptake in Escherichia coli heat-stable enterotoxin induced diarrhoea in mice.	Sugars	45-50	calmodulin 2	Mus musculus	13-23
3124851-4	1987	Ca2+ channel blocker and calmodulin inhibitor significantly increased (p less than 0.01) the uptake of sugar in both the groups, however, the changes were more pronounced in the experimental group.	Sugars	103-108	calmodulin 2	Mus musculus	25-35
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	calmidazolium	27-40	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Trifluoperazine	42-57	calmodulin 2	Mus musculus	4-14
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Trifluoperazine	42-57	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Trifluoperazine	42-57	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	4-14
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	W 7	62-65	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Histamine	132-141	calmodulin 2	Mus musculus	4-14
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Histamine	132-141	calmodulin 2	Mus musculus	196-206
2446480-7	1987	The calmodulin antagonists calmidazolium, trifluoperazine and W-7 are also highly effective inhibitors of both the Ca2+ changes and histamine release in direct proportion to their potency against calmodulin-dependent phosphodiesterase, implicating calmodulin in the regulation of stimulus-secretion in MC9 cells.	Histamine	132-141	calmodulin 2	Mus musculus	196-206
3113496-6	1987	Verapamil, a calcium channel blocker, and trifluoperazine, a calmodulin inhibitor, reversed the effects of Ca2+-ionophore and heat-stable enterotoxin.	Trifluoperazine	42-57	calmodulin 2	Mus musculus	61-71
3651539-7	1987	These results indicate that calmodulin inhibitors can protect against certain toxic effects of cadmium and are consistent with the hypothesis that some of the effects of cadmium may result from the improper activation of calmodulin-dependent enzymes.	Cadmium	95-102	calmodulin 2	Mus musculus	28-38
3651539-0	1987	Calmodulin inhibitors protect against cadmium-induced testicular damage in mice.	Cadmium	38-45	calmodulin 2	Mus musculus	0-10
3651539-1	1987	Recent reports showing that cadmium can interact with calmodulin and activate calmodulin-sensitive enzymes have lead us to examine the effects of calmodulin inhibitors on cadmium-induced testicular toxicity in mice.	Cadmium	28-35	calmodulin 2	Mus musculus	54-64
3651539-1	1987	Recent reports showing that cadmium can interact with calmodulin and activate calmodulin-sensitive enzymes have lead us to examine the effects of calmodulin inhibitors on cadmium-induced testicular toxicity in mice.	Cadmium	28-35	calmodulin 2	Mus musculus	78-88
3651539-1	1987	Recent reports showing that cadmium can interact with calmodulin and activate calmodulin-sensitive enzymes have lead us to examine the effects of calmodulin inhibitors on cadmium-induced testicular toxicity in mice.	Cadmium	28-35	calmodulin 2	Mus musculus	78-88
3651539-7	1987	These results indicate that calmodulin inhibitors can protect against certain toxic effects of cadmium and are consistent with the hypothesis that some of the effects of cadmium may result from the improper activation of calmodulin-dependent enzymes.	Cadmium	95-102	calmodulin 2	Mus musculus	221-231
3651539-7	1987	These results indicate that calmodulin inhibitors can protect against certain toxic effects of cadmium and are consistent with the hypothesis that some of the effects of cadmium may result from the improper activation of calmodulin-dependent enzymes.	Cadmium	170-177	calmodulin 2	Mus musculus	28-38
3651539-7	1987	These results indicate that calmodulin inhibitors can protect against certain toxic effects of cadmium and are consistent with the hypothesis that some of the effects of cadmium may result from the improper activation of calmodulin-dependent enzymes.	Cadmium	170-177	calmodulin 2	Mus musculus	221-231
3585411-6	1987	Chlorpromazine (20 microM), trifluoperazine (20 microM), and W13 (75 microM), inhibitors of CAM activity, also suppressed MP cytotoxicity for SV3T3 cells when added to the assay, suggesting that Ca2+-activated CAM is an integral component in expression of MP cytotoxicity.	Chlorpromazine	0-14	calmodulin 2	Mus musculus	92-95
3585411-6	1987	Chlorpromazine (20 microM), trifluoperazine (20 microM), and W13 (75 microM), inhibitors of CAM activity, also suppressed MP cytotoxicity for SV3T3 cells when added to the assay, suggesting that Ca2+-activated CAM is an integral component in expression of MP cytotoxicity.	Chlorpromazine	0-14	calmodulin 2	Mus musculus	210-213
3585411-6	1987	Chlorpromazine (20 microM), trifluoperazine (20 microM), and W13 (75 microM), inhibitors of CAM activity, also suppressed MP cytotoxicity for SV3T3 cells when added to the assay, suggesting that Ca2+-activated CAM is an integral component in expression of MP cytotoxicity.	Trifluoperazine	28-43	calmodulin 2	Mus musculus	92-95
3585411-6	1987	Chlorpromazine (20 microM), trifluoperazine (20 microM), and W13 (75 microM), inhibitors of CAM activity, also suppressed MP cytotoxicity for SV3T3 cells when added to the assay, suggesting that Ca2+-activated CAM is an integral component in expression of MP cytotoxicity.	Trifluoperazine	28-43	calmodulin 2	Mus musculus	210-213
3817105-3	1987	The quail cells can be identified histologically and easily recognized by Feulgen-staining which is demonstrated in the presence of quail chondro- or osteoclasts in a mouse long bone rudiment cultured on the CAM.	feulgen	74-81	calmodulin 2	Mus musculus	208-211
3579963-0	1987	Intestinal brush border calmodulin: key role in the regulation of NaCl transport in Giardia lamblia infected mice.	Sodium Chloride	66-70	calmodulin 2	Mus musculus	24-34
3579963-4	1987	In the presence of calmodulin inhibitor, trifluoperazine (TFP), the transport of Na+ and Cl- increased significantly (p less than 0.05) as compared to in the absence of inhibitor while transport of Ca2+ remained unaltered.	Trifluoperazine	41-56	calmodulin 2	Mus musculus	19-29
3579963-4	1987	In the presence of calmodulin inhibitor, trifluoperazine (TFP), the transport of Na+ and Cl- increased significantly (p less than 0.05) as compared to in the absence of inhibitor while transport of Ca2+ remained unaltered.	Trifluoperazine	58-61	calmodulin 2	Mus musculus	19-29
3038506-0	1987	The inhibitory effects of calmodulin antagonists on TSH-stimulated thyroid hormone release by mouse thyroid lobes.	Thyrotropin	52-55	calmodulin 2	Mus musculus	26-36
3038506-2	1987	More recently, in vitro evidence suggests that a calcium-binding protein, calmodulin, is also involved in the release of many hormones.	Calcium	49-56	calmodulin 2	Mus musculus	74-84
3038506-3	1987	So we examined the effects of several types of calmodulin antagonists on TSH-stimulated thyroid hormone release in vitro.	Thyrotropin	73-76	calmodulin 2	Mus musculus	47-57
3038506-9	1987	These results suggest that calmodulin plays an important role in TSH-stimulated thyroid hormone release and further that this mechanism exists, at least in part, at the site subsequent to the generation of cAMP.	Cyclic AMP	206-210	calmodulin 2	Mus musculus	27-37
3553102-1	1987	Calmodulin (CaM) is a major calcium-binding protein in the brain, where its immunoreactivity is mainly localized in the neurons.	Calcium	28-35	calmodulin 2	Mus musculus	0-10
3495504-0	1987	Inhibition of contact sensitivity to oxazolone by the calmodulin inhibitor trifluoroperazine.	Trifluoperazine	75-92	calmodulin 2	Mus musculus	54-64
3495504-1	1987	Topical application of trifluoroperazine (TFP), a calmodulin inhibitor, on the skin of CBA mice previously immunized with 2-phenyl-4-ethoximethylene-oxazolone (oxazolone) blocks the expression phase of contact sensitivity.	Trifluoperazine	23-40	calmodulin 2	Mus musculus	50-60
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	Nickel(2+)	99-103	calmodulin 2	Mus musculus	37-47
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	Nickel(2+)	99-103	calmodulin 2	Mus musculus	206-216
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	magnesium ion	147-151	calmodulin 2	Mus musculus	37-47
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	N-methyl-valyl-amiclenomycin	156-160	calmodulin 2	Mus musculus	37-47
2439690-7	1987	Quinine, an inhibitor of Ca2+-activated K+ channels, abolished both Ca2+- and calmodulin-induced hyperpolarizations.	Quinine	0-7	calmodulin 2	Mus musculus	78-88
2441572-0	1987	Potentiation of sensitivity to bleomycin and the drug-induced DNA damage in EMT6 cells by the calmodulin inhibitor trifluoperazine.	Bleomycin	31-40	calmodulin 2	Mus musculus	94-104
2441572-0	1987	Potentiation of sensitivity to bleomycin and the drug-induced DNA damage in EMT6 cells by the calmodulin inhibitor trifluoperazine.	Trifluoperazine	115-130	calmodulin 2	Mus musculus	94-104
2441572-1	1987	It has been shown that inhibitors of calmodulin can increase the sensitivity of rodent cells to Bleomycin by interfering with DNA repair functions.	Bleomycin	96-105	calmodulin 2	Mus musculus	37-47
2441572-3	1987	This toxic effect can be potentiated by the addition of a nonlethal dose of the calmodulin inhibitor Trifluoperazine.	Trifluoperazine	101-116	calmodulin 2	Mus musculus	80-90
3495504-0	1987	Inhibition of contact sensitivity to oxazolone by the calmodulin inhibitor trifluoroperazine.	Oxazolone	37-46	calmodulin 2	Mus musculus	54-64
2439690-2	1987	These repeated hyperpolarizations were inhibited by putative calmodulin antagonists, trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and promethazine (PMZ), and the concentrations required for half-maximal inhibition were 25, 30 and 300 microM, respectively.	W 7	160-163	calmodulin 2	Mus musculus	61-71
2439690-2	1987	These repeated hyperpolarizations were inhibited by putative calmodulin antagonists, trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and promethazine (PMZ), and the concentrations required for half-maximal inhibition were 25, 30 and 300 microM, respectively.	Promethazine	169-181	calmodulin 2	Mus musculus	61-71
2439690-2	1987	These repeated hyperpolarizations were inhibited by putative calmodulin antagonists, trifluoperazine (TFP), N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and promethazine (PMZ), and the concentrations required for half-maximal inhibition were 25, 30 and 300 microM, respectively.	Promethazine	183-186	calmodulin 2	Mus musculus	61-71
2439690-4	1987	Another calmodulin antagonist, chlorpromazine (CPZ), was also effective, but CPZ-sulfoxide was not.	Chlorpromazine	31-45	calmodulin 2	Mus musculus	8-18
2439690-4	1987	Another calmodulin antagonist, chlorpromazine (CPZ), was also effective, but CPZ-sulfoxide was not.	Chlorpromazine	47-50	calmodulin 2	Mus musculus	8-18
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	strontium cation	84-88	calmodulin 2	Mus musculus	37-47
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	strontium cation	84-88	calmodulin 2	Mus musculus	206-216
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	Manganese(2+)	90-94	calmodulin 2	Mus musculus	37-47
2439690-5	1987	Intracellular pressure injections of calmodulin-interacting divalent cations, Ca2+, Sr2+, Mn2+ and Ni2+, elicited slow hyperpolarizations, whereas Mg2+ and Ba2+, which are known to be essentially inert for calmodulin, failed to evoke any responses.	Manganese(2+)	90-94	calmodulin 2	Mus musculus	206-216
3553102-1	1987	Calmodulin (CaM) is a major calcium-binding protein in the brain, where its immunoreactivity is mainly localized in the neurons.	Calcium	28-35	calmodulin 2	Mus musculus	12-15
2428456-0	1986	Calmodulin antagonists inhibit dihydropyridine calcium channel activator (BAY-K-8644) induced cGMP synthesis in pituitary tumor cells.	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	74-84	calmodulin 2	Mus musculus	0-10
3756902-0	1986	Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.	Doxorubicin	14-24	calmodulin 2	Mus musculus	174-184
3756902-0	1986	Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.	valrubicin	29-68	calmodulin 2	Mus musculus	174-184
3756902-0	1986	Modulation of adriamycin and N-trifluoroacetyladriamycin-14-valerate induced effects on cell cycle traverse and cytotoxicity in P388 mouse leukemia cells by caffeine and the calmodulin inhibitor trifluoperazine.	Trifluoperazine	195-210	calmodulin 2	Mus musculus	174-184
2428790-0	1986	Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoperazine) in mouse tumor cells.	Bleomycin	15-24	calmodulin 2	Mus musculus	45-55
2428790-0	1986	Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoperazine) in mouse tumor cells.	Trifluoperazine	67-82	calmodulin 2	Mus musculus	45-55
3524864-0	1986	Role of calmodulin in cadmium-induced microtubule disassembly.	Cadmium	22-29	calmodulin 2	Mus musculus	8-18
3524864-3	1986	Our results suggest that Cd(II) affects microtubules by activating calmodulin associated with the cytoskeleton.	cd(ii)	25-31	calmodulin 2	Mus musculus	67-77
3037094-6	1987	In contrast, soluble calmodulin levels decreased by 15% in the 6-OHDA-lesioned striatum, suggesting that soluble calmodulin is enriched in presynaptic dopaminergic terminals.	Oxidopamine	63-69	calmodulin 2	Mus musculus	21-31
3037094-6	1987	In contrast, soluble calmodulin levels decreased by 15% in the 6-OHDA-lesioned striatum, suggesting that soluble calmodulin is enriched in presynaptic dopaminergic terminals.	Oxidopamine	63-69	calmodulin 2	Mus musculus	113-123
2956551-2	1987	Mouse lenses were incubated with naphthalenesulfonamide compounds (W-5, W-7, W-12 and W-13) which act as calmodulin antagonists.	naphthalenesulfonamide	33-55	calmodulin 2	Mus musculus	105-115
2956551-3	1987	When lens Ca2+-ATPase activity was inhibited by those calmodulin antagonists, an accumulation of calcium in the lens was observed.	Calcium	97-104	calmodulin 2	Mus musculus	54-64
3789751-5	1986	We found that a calmodulin antagonist, quercetin, anti-inflammatory agents and tannic acids were able to act as new anti-tumor promoters.	Tannins	79-91	calmodulin 2	Mus musculus	16-26
3460695-0	1986	Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists.	anthrapyrazole	14-29	calmodulin 2	Mus musculus	133-143
3460695-0	1986	Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists.	Anthracyclines	34-48	calmodulin 2	Mus musculus	133-143
3460695-5	1986	The calcium channel blockers verapamil (VER) and diltiazem and the calmodulin antagonist trifluoperazine potentiated the cytotoxicity of the anthrapyrazoles and ADR in P388R.	Trifluoperazine	89-104	calmodulin 2	Mus musculus	67-77
3460695-5	1986	The calcium channel blockers verapamil (VER) and diltiazem and the calmodulin antagonist trifluoperazine potentiated the cytotoxicity of the anthrapyrazoles and ADR in P388R.	anthrapyrazole	141-156	calmodulin 2	Mus musculus	67-77
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	calmidazolium	182-195	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	Trifluoperazine	209-224	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	Chlorprothixene	238-253	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	Chlorpromazine	267-281	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	295-299	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	W 12	313-317	calmodulin 2	Mus musculus	132-142
3759442-3	1986	Since the order of the potency of these drugs against the activation of RAW-264 cells was much the same as their ability to inhibit calmodulin-dependent phosphodiestherase activity: calmidazolium greater than trifluoperazine greater than chlorprothixene greater than chlorpromazine greater than W-13, and because W-12, a nonactive analog of W-13, failed to inhibit the process of activation, we believe that the development of cytolytic activity in RAW-264 cells may be dependent on calmodulin.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	341-345	calmodulin 2	Mus musculus	132-142
3741420-1	1986	Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs.	Chlorpromazine	0-14	calmodulin 2	Mus musculus	40-50
3741420-1	1986	Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs.	2-fluoropyrimidine	133-149	calmodulin 2	Mus musculus	40-50
3524864-2	1986	We show in this paper that Cd(II), an environmental and occupational health hazard, induces microtubule disassembly in an in situ cytoskeleton model system, and that the calmodulin inhibitors, trifluoperazine and Compound 48/80, prevent this Cd(II)-induced microtubule disassembly.	cd(ii)	27-33	calmodulin 2	Mus musculus	170-180
2428456-0	1986	Calmodulin antagonists inhibit dihydropyridine calcium channel activator (BAY-K-8644) induced cGMP synthesis in pituitary tumor cells.	Cyclic GMP	94-98	calmodulin 2	Mus musculus	0-10
2428456-2	1986	The recent report that calmodulin antagonists could inhibit dihydropyridine binding in several tissues suggested that these agents might also affect the cyclic nucleotide response to BAY-K-8644.	1,4-dihydropyridine	60-75	calmodulin 2	Mus musculus	23-33
2428456-2	1986	The recent report that calmodulin antagonists could inhibit dihydropyridine binding in several tissues suggested that these agents might also affect the cyclic nucleotide response to BAY-K-8644.	Nucleotides, Cyclic	153-170	calmodulin 2	Mus musculus	23-33
2428456-2	1986	The recent report that calmodulin antagonists could inhibit dihydropyridine binding in several tissues suggested that these agents might also affect the cyclic nucleotide response to BAY-K-8644.	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	183-193	calmodulin 2	Mus musculus	23-33
2428456-3	1986	In fact, TMB-8, trifluoperazine, and melittin, described as in vitro antagonists of calmodulin-dependent enzyme activities, all inhibited BAY-K-8644 induced cGMP synthesis in a concentration-dependent manner.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	9-14	calmodulin 2	Mus musculus	84-94
2428456-3	1986	In fact, TMB-8, trifluoperazine, and melittin, described as in vitro antagonists of calmodulin-dependent enzyme activities, all inhibited BAY-K-8644 induced cGMP synthesis in a concentration-dependent manner.	Trifluoperazine	16-31	calmodulin 2	Mus musculus	84-94
2428456-3	1986	In fact, TMB-8, trifluoperazine, and melittin, described as in vitro antagonists of calmodulin-dependent enzyme activities, all inhibited BAY-K-8644 induced cGMP synthesis in a concentration-dependent manner.	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	138-148	calmodulin 2	Mus musculus	84-94
2428456-3	1986	In fact, TMB-8, trifluoperazine, and melittin, described as in vitro antagonists of calmodulin-dependent enzyme activities, all inhibited BAY-K-8644 induced cGMP synthesis in a concentration-dependent manner.	Cyclic GMP	157-161	calmodulin 2	Mus musculus	84-94
3735810-1	1986	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a well-known inhibitor of the calmodulin-dependent processes, strongly enhanced phagocytosis and ingestion of polystyrene latex beads into the peritoneal macrophages of BALB/c mice after the i.p.	W 7	0-3	calmodulin 2	Mus musculus	89-99
3090566-0	1986	Chronic ethanol administration inhibits calmodulin-dependent Ca++ uptake in synaptosomal membranes.	Ethanol	8-15	calmodulin 2	Mus musculus	40-50
3090566-2	1986	Addition of calmodulin (2.5 micrograms) to membranes from mice receiving the control diet produced a slight stimulation of ATP dependent Ca++ uptake.	Adenosine Triphosphate	123-126	calmodulin 2	Mus musculus	12-22
3090566-4	1986	When calmodulin was added to membranes isolated from mice receiving ETOH on Days 1, 4 and 7 ATP-dependent Ca++ uptake was significantly stimulated (p less than 0.01) compared to (1) ETOH treated membranes in absence of calmodulin, and (2) control membranes.	Ethanol	68-72	calmodulin 2	Mus musculus	5-15
3090566-4	1986	When calmodulin was added to membranes isolated from mice receiving ETOH on Days 1, 4 and 7 ATP-dependent Ca++ uptake was significantly stimulated (p less than 0.01) compared to (1) ETOH treated membranes in absence of calmodulin, and (2) control membranes.	Adenosine Triphosphate	92-95	calmodulin 2	Mus musculus	5-15
3735810-1	1986	W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a well-known inhibitor of the calmodulin-dependent processes, strongly enhanced phagocytosis and ingestion of polystyrene latex beads into the peritoneal macrophages of BALB/c mice after the i.p.	W 7	5-56	calmodulin 2	Mus musculus	89-99
3735810-2	1986	injection, whereas W-5 [N-(6-aminohexyl)-naphthalene sulfonamide], a less effective calmodulin antagonist, was much weaker than W-7.	N-(6-aminohexyl)-1-naphthalenesulfonamide	19-22	calmodulin 2	Mus musculus	84-94
3735810-2	1986	injection, whereas W-5 [N-(6-aminohexyl)-naphthalene sulfonamide], a less effective calmodulin antagonist, was much weaker than W-7.	n-(6-aminohexyl)-naphthalene sulfonamide	24-64	calmodulin 2	Mus musculus	84-94
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	33-101	calmodulin 2	Mus musculus	189-199
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	33-101	calmodulin 2	Mus musculus	156-166
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	103-107	calmodulin 2	Mus musculus	156-166
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	103-107	calmodulin 2	Mus musculus	189-199
3083690-7	1986	Exogenous calmodulin restored the ability of Ca2+ to stimulate the adenylate cyclase activity associated with EGTA-treated membranes.	Egtazic Acid	110-114	calmodulin 2	Mus musculus	10-20
3083690-9	1986	The effect of trifluoperazine could be reversed by exogenous calmodulin (0.5 or 5.0 micrograms).	Trifluoperazine	14-29	calmodulin 2	Mus musculus	61-71
2963220-4	1986	Calmodulin phosphodiesterase inhibitor 8-MeOMeMIX produced a dose-dependent increase in 8-BrcAMP stimulation, suggesting that inhibition of cAMP degradation is the mechanism of enhancement of 8-BrcAMP-induced secretion in the presence of W7.	8-meomemix	39-49	calmodulin 2	Mus musculus	0-10
3947398-0	1986	Factors governing the modulation of vinca-alkaloid resistance in doxorubicin-resistant cells by the calmodulin inhibitor trifluoperazine.	Doxorubicin	65-76	calmodulin 2	Mus musculus	100-110
3947398-0	1986	Factors governing the modulation of vinca-alkaloid resistance in doxorubicin-resistant cells by the calmodulin inhibitor trifluoperazine.	Trifluoperazine	121-136	calmodulin 2	Mus musculus	100-110
3947398-1	1986	Calmodulin inhibitors enhance the cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by augmenting cellular accumulation and retention of drug.	Doxorubicin	55-66	calmodulin 2	Mus musculus	0-10
3947398-1	1986	Calmodulin inhibitors enhance the cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by augmenting cellular accumulation and retention of drug.	Doxorubicin	68-71	calmodulin 2	Mus musculus	0-10
3947398-1	1986	Calmodulin inhibitors enhance the cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by augmenting cellular accumulation and retention of drug.	Doxorubicin	76-79	calmodulin 2	Mus musculus	0-10
3947398-1	1986	Calmodulin inhibitors enhance the cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by augmenting cellular accumulation and retention of drug.	Doxorubicin	76-79	calmodulin 2	Mus musculus	0-10
2418859-0	1986	Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoperazine) in mouse tumour cells: II.	Trifluoperazine	67-82	calmodulin 2	Mus musculus	45-55
2418859-2	1986	We have reported in the preceding paper that the treatment of plateau phase mouse EMT6 tumour cells with a combination of hyperthermia (HT; 44 degrees C) and trifluoperazine (TFP; 30 micrograms ml-1; an inhibitor of calmodulin) greatly enhances the cytotoxicity of the antitumour drug belomycin (BLM).	Trifluoperazine	158-173	calmodulin 2	Mus musculus	216-226
2418860-0	1986	Interaction of bleomycin, hyperthermia and a calmodulin inhibitor (trifluoperazine) in mouse tumour cells: I.	Trifluoperazine	67-82	calmodulin 2	Mus musculus	45-55
2418860-2	1986	Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions.	Bleomycin	135-144	calmodulin 2	Mus musculus	76-86
2828975-2	1986	Based on its potent agonist activity in rabbit vas deferens and the low potency of naloxone to antagonize its agonist effect in the guinea pig ileum and mouse vas deferens, CAM can be considered as kappa agonist.	Naloxone	83-91	calmodulin 2	Mus musculus	173-176
3707847-0	1986	Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.	Trifluoperazine	33-48	calmodulin 2	Mus musculus	12-22
3707847-0	1986	Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.	Daunorubicin	138-150	calmodulin 2	Mus musculus	12-22
3707847-0	1986	Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.	Doxorubicin	155-166	calmodulin 2	Mus musculus	12-22
3707847-0	1986	Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.	Doxorubicin	168-178	calmodulin 2	Mus musculus	12-22
3707847-0	1986	Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells.	Doxorubicin	183-194	calmodulin 2	Mus musculus	12-22
2935191-2	1986	The purification procedure included removal of endogenous calmodulin from a Triton X-100 solubilizate of the membranes by DEAE ion-exchange chromatography as an essential step.	2-diethylaminoethanol	122-126	calmodulin 2	Mus musculus	58-68
2963220-4	1986	Calmodulin phosphodiesterase inhibitor 8-MeOMeMIX produced a dose-dependent increase in 8-BrcAMP stimulation, suggesting that inhibition of cAMP degradation is the mechanism of enhancement of 8-BrcAMP-induced secretion in the presence of W7.	8-Bromo Cyclic Adenosine Monophosphate	88-96	calmodulin 2	Mus musculus	0-10
2963220-4	1986	Calmodulin phosphodiesterase inhibitor 8-MeOMeMIX produced a dose-dependent increase in 8-BrcAMP stimulation, suggesting that inhibition of cAMP degradation is the mechanism of enhancement of 8-BrcAMP-induced secretion in the presence of W7.	Cyclic AMP	92-96	calmodulin 2	Mus musculus	0-10
2963220-4	1986	Calmodulin phosphodiesterase inhibitor 8-MeOMeMIX produced a dose-dependent increase in 8-BrcAMP stimulation, suggesting that inhibition of cAMP degradation is the mechanism of enhancement of 8-BrcAMP-induced secretion in the presence of W7.	8-Bromo Cyclic Adenosine Monophosphate	192-200	calmodulin 2	Mus musculus	0-10
4028171-5	1985	Macrophage activation was also inhibited by chlorpromazine, W-7, and calmidazolium at concentrations known to perturb calmodulin function.	Chlorpromazine	44-58	calmodulin 2	Mus musculus	118-128
4073927-1	1985	Ethyl-O-[N-(p-carboxyphenyl) carbamoyl]-mycophenolate (CAM), a mycophenolic acid (MPA) derivative, has been evaluated in terms of influence of treatment schedule and route of administration on antitumor activity in mice bearing L 1210 leukemia and cross-resistance to 6-MP was studied.	ethyl-o-[n-(p-carboxyphenyl) carbamoyl]-mycophenolate	0-53	calmodulin 2	Mus musculus	55-58
4073927-1	1985	Ethyl-O-[N-(p-carboxyphenyl) carbamoyl]-mycophenolate (CAM), a mycophenolic acid (MPA) derivative, has been evaluated in terms of influence of treatment schedule and route of administration on antitumor activity in mice bearing L 1210 leukemia and cross-resistance to 6-MP was studied.	Mycophenolic Acid	82-85	calmodulin 2	Mus musculus	55-58
4062971-0	1985	Characteristics of the cytotoxic effects of the phenothiazine class of calmodulin antagonists.	phenothiazine	48-61	calmodulin 2	Mus musculus	71-81
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	polyacrylamide	59-73	calmodulin 2	Mus musculus	0-10
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	polyacrylamide	59-73	calmodulin 2	Mus musculus	12-15
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	Phenothiazines	128-142	calmodulin 2	Mus musculus	0-10
4062971-6	1985	Calmodulin (CaM), purified from L1210 cells by preparative polyacrylamide gel electrophoresis, had sensitivity to inhibition by phenothiazines similar to that reported for CaM prepared from brain.	Phenothiazines	128-142	calmodulin 2	Mus musculus	12-15
4062971-11	1985	These studies add pharmacological support for CaM being a potential intracellular target for the antiproliferative effect of the phenothiazines.	Phenothiazines	129-143	calmodulin 2	Mus musculus	46-49
4076303-0	1985	Effects of morphine and aging on brain calmodulin levels in mice.	Morphine	11-19	calmodulin 2	Mus musculus	39-49
4076303-2	1985	Acutely, morphine caused significant (two-fold) increases in calmodulin in striatal regions from immature and old mice, and increased calmodulin after morphine administration to mature mice occurred only in the cerebellum.	Morphine	9-17	calmodulin 2	Mus musculus	61-71
4076303-2	1985	Acutely, morphine caused significant (two-fold) increases in calmodulin in striatal regions from immature and old mice, and increased calmodulin after morphine administration to mature mice occurred only in the cerebellum.	Morphine	151-159	calmodulin 2	Mus musculus	134-144
4076303-3	1985	After tolerance to morphine had developed, calmodulin levels in all brain regions were the same as those from placebo-implanted mice.	Morphine	19-27	calmodulin 2	Mus musculus	43-53
4044638-1	1985	We have prepared and partially characterized a lissamine-rhodamine B fluorescent analogue of calmodulin, LRB-CM.	lissamine rhodamine B	47-68	calmodulin 2	Mus musculus	93-103
4044638-14	1985	The mobility of LRB-CM in the cytoplasm was sensitive to treatment of the cells with trifluoperazine, which suggests that at least some of the intracellular binding sites are specific for calmodulin in the calcium-bound form.	Trifluoperazine	85-100	calmodulin 2	Mus musculus	188-198
4044638-14	1985	The mobility of LRB-CM in the cytoplasm was sensitive to treatment of the cells with trifluoperazine, which suggests that at least some of the intracellular binding sites are specific for calmodulin in the calcium-bound form.	Calcium	206-213	calmodulin 2	Mus musculus	188-198
4028171-5	1985	Macrophage activation was also inhibited by chlorpromazine, W-7, and calmidazolium at concentrations known to perturb calmodulin function.	W 7	60-63	calmodulin 2	Mus musculus	118-128
4028171-5	1985	Macrophage activation was also inhibited by chlorpromazine, W-7, and calmidazolium at concentrations known to perturb calmodulin function.	calmidazolium	69-82	calmodulin 2	Mus musculus	118-128
4028171-6	1985	The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function.	Calcium	78-85	calmodulin 2	Mus musculus	294-304
4028171-6	1985	The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function.	Calcium	135-142	calmodulin 2	Mus musculus	294-304
4028171-6	1985	The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function.	Calcium	135-142	calmodulin 2	Mus musculus	294-304
2861080-10	1985	Inhibition of the stimulatory response by low concentrations of three distinct groups of calmodulin inhibitors, i.e. neuroleptics, naphthalenesulfonamide agents and compound 48/80, suggests a role for calmodulin in this process.	naphthalenesulfonamide	131-153	calmodulin 2	Mus musculus	89-99
4070338-0	1985	Effect of calmodulin antagonists on calcium and ethanol-induced sleeping time in mice.	Calcium	36-43	calmodulin 2	Mus musculus	10-20
4070338-0	1985	Effect of calmodulin antagonists on calcium and ethanol-induced sleeping time in mice.	Ethanol	48-55	calmodulin 2	Mus musculus	10-20
4070338-1	1985	This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase.	Calcium	51-58	calmodulin 2	Mus musculus	112-122
4070338-1	1985	This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase.	Calcium	51-58	calmodulin 2	Mus musculus	129-139
4070338-1	1985	This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase.	Ethanol	75-82	calmodulin 2	Mus musculus	112-122
4070338-1	1985	This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase.	Ethanol	75-82	calmodulin 2	Mus musculus	129-139
4070338-7	1985	The results would suggest a probable mechanism in which Ca++ prolongs ethanol-induced sleeping time by activating tyrosine hydroxylase and tryptophan hydroxylase through intracerebral calmodulin and calmodulin-dependent protein kinase, which subsequently raise the levels of 5-HT, DA and NE.	Ethanol	70-77	calmodulin 2	Mus musculus	184-194
4070338-7	1985	The results would suggest a probable mechanism in which Ca++ prolongs ethanol-induced sleeping time by activating tyrosine hydroxylase and tryptophan hydroxylase through intracerebral calmodulin and calmodulin-dependent protein kinase, which subsequently raise the levels of 5-HT, DA and NE.	Ethanol	70-77	calmodulin 2	Mus musculus	199-209
2992708-10	1985	Calcium redistributed soluble striatal calmodulin into the particulate fraction and EGTA shifted calmodulin from the particulate into the soluble fraction.	Calcium	0-7	calmodulin 2	Mus musculus	39-49
2992708-10	1985	Calcium redistributed soluble striatal calmodulin into the particulate fraction and EGTA shifted calmodulin from the particulate into the soluble fraction.	Egtazic Acid	84-88	calmodulin 2	Mus musculus	97-107
2932108-0	1985	Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells.	Trifluoperazine	21-36	calmodulin 2	Mus musculus	0-10
2932108-0	1985	Calmodulin inhibitor trifluoperazine selectively enhances cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant P388 mouse leukemia cells.	Doxorubicin	125-136	calmodulin 2	Mus musculus	0-10
2932108-5	1985	The study demonstrates that the calmodulin inhibitor trifluoperazine induces a specific and marked enhancement in the cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant cells.	Trifluoperazine	53-68	calmodulin 2	Mus musculus	32-42
2932108-5	1985	The study demonstrates that the calmodulin inhibitor trifluoperazine induces a specific and marked enhancement in the cytotoxic effects of strong vs weak DNA binding antitumor drugs in doxorubicin-resistant cells.	Doxorubicin	185-196	calmodulin 2	Mus musculus	32-42
2861080-10	1985	Inhibition of the stimulatory response by low concentrations of three distinct groups of calmodulin inhibitors, i.e. neuroleptics, naphthalenesulfonamide agents and compound 48/80, suggests a role for calmodulin in this process.	naphthalenesulfonamide	131-153	calmodulin 2	Mus musculus	201-211
3884713-9	1985	The total and cytoskeletal-associated amounts of calmodulin per unit of protein were determined by radioimmune assay and 125I labeling followed by SDS-PAGE.	Sodium Dodecyl Sulfate	147-150	calmodulin 2	Mus musculus	49-59
4015040-1	1985	Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells.	Flunarizine	0-11	calmodulin 2	Mus musculus	53-63
4015040-1	1985	Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells.	Calcium	15-22	calmodulin 2	Mus musculus	53-63
3925027-10	1985	The stimulation by FBS and A23187 was suppressed by calmodulin antagonists, though the effect of A23187 was much more sensitive to the antagonists when compared to that of FBS.	Calcimycin	27-33	calmodulin 2	Mus musculus	52-62
3925027-10	1985	The stimulation by FBS and A23187 was suppressed by calmodulin antagonists, though the effect of A23187 was much more sensitive to the antagonists when compared to that of FBS.	Calcimycin	97-103	calmodulin 2	Mus musculus	52-62
2992977-5	1985	It was temperature-dependent, independent of external calcium, but was blocked by trifluoperazine (TFP), a calmodulin antagonist.	Trifluoperazine	82-97	calmodulin 2	Mus musculus	107-117
2992977-5	1985	It was temperature-dependent, independent of external calcium, but was blocked by trifluoperazine (TFP), a calmodulin antagonist.	Trifluoperazine	99-102	calmodulin 2	Mus musculus	107-117
2579165-2	1985	We became interested in the role of the calcium binding protein, calmodulin, in hyperproliferative, low calcium regulated keratinocytes in vitro and in the in vivo hyperproliferative state, psoriasis.	Calcium	40-47	calmodulin 2	Mus musculus	65-75
2857771-0	1985	Effects of aging and morphine administration on calmodulin and calmodulin-regulated enzymes in striata of mice.	Morphine	21-29	calmodulin 2	Mus musculus	48-58
2857771-0	1985	Effects of aging and morphine administration on calmodulin and calmodulin-regulated enzymes in striata of mice.	Morphine	21-29	calmodulin 2	Mus musculus	63-73
2857771-4	1985	Acute morphine treatment produced the following: (1) increases in calmodulin levels in the young and old mice while having no effect on mature levels; (2) increases in activities of guanylate cyclase of mature mice while decreasing those of the old mice; (3) no effects on activity of adenylate cyclase; (4) decreased activity of cyclic AMP-phosphodiesterase in young mice only; (5) decreased activity of Ca2+, Mg2+-ATPase in the old mice only.	Morphine	6-14	calmodulin 2	Mus musculus	66-76
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Edetic Acid	80-84	calmodulin 2	Mus musculus	25-35
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Edetic Acid	80-84	calmodulin 2	Mus musculus	64-74
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Egtazic Acid	89-93	calmodulin 2	Mus musculus	25-35
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Egtazic Acid	89-93	calmodulin 2	Mus musculus	64-74
2579165-3	1985	Calmodulin levels were measured by radioimmune assay in neonatal mouse keratinocytes grown in 0.02 mM calcium (hyperproliferative) and 1.2 mM calcium (normal) media, and in cells that had been grown in low calcium medium and then switched to normal calcium.	Calcium	102-109	calmodulin 2	Mus musculus	0-10
2579165-5	1985	However, when low calcium monolayers were compared to the normal basal monolayer, the low calcium hyperproliferative cells had more calmodulin.	Calcium	18-25	calmodulin 2	Mus musculus	132-142
2579165-6	1985	Cells that were switched from 0.02 mM calcium to 1.2 mM calcium showed increasing calmodulin levels over time.	Calcium	38-45	calmodulin 2	Mus musculus	82-92
2579165-6	1985	Cells that were switched from 0.02 mM calcium to 1.2 mM calcium showed increasing calmodulin levels over time.	Calcium	56-63	calmodulin 2	Mus musculus	82-92
2578538-2	1985	W-13 (N-(4-aminobutyl)-5-chloro-2-naphthalenesulphonamide), a calmodulin inhibitor, reduced prolactin-induced differentiation by 80% while inhibiting insulin- and cortisol-induced RNA synthesis only 40%.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	0-4	calmodulin 2	Mus musculus	62-72
2982510-1	1985	The effects of BCNU, CCNU, methyl-CCNU, streptozotocin, and chlorozotocin on calmodulin activity were studied in vitro and in vivo.	Streptozocin	40-54	calmodulin 2	Mus musculus	77-87
2982510-1	1985	The effects of BCNU, CCNU, methyl-CCNU, streptozotocin, and chlorozotocin on calmodulin activity were studied in vitro and in vivo.	chlorozotocin	60-73	calmodulin 2	Mus musculus	77-87
2982510-2	1985	Preincubation of BCNU, CCNU, and methyl-CCNU with calmodulin produced a concentration-dependent inhibition of in vitro calmodulin activity expressed as stimulation of cyclic nucleotide phosphodiesterase.	Carmustine	17-21	calmodulin 2	Mus musculus	50-60
2982510-2	1985	Preincubation of BCNU, CCNU, and methyl-CCNU with calmodulin produced a concentration-dependent inhibition of in vitro calmodulin activity expressed as stimulation of cyclic nucleotide phosphodiesterase.	Carmustine	17-21	calmodulin 2	Mus musculus	119-129
2982510-2	1985	Preincubation of BCNU, CCNU, and methyl-CCNU with calmodulin produced a concentration-dependent inhibition of in vitro calmodulin activity expressed as stimulation of cyclic nucleotide phosphodiesterase.	Lomustine	23-27	calmodulin 2	Mus musculus	50-60
2982510-2	1985	Preincubation of BCNU, CCNU, and methyl-CCNU with calmodulin produced a concentration-dependent inhibition of in vitro calmodulin activity expressed as stimulation of cyclic nucleotide phosphodiesterase.	Lomustine	23-27	calmodulin 2	Mus musculus	119-129
2982510-5	1985	Calmodulin inhibition by methyl-CCNU was dependent on the concentration of calcium in the preincubation mixture.	Semustine	25-36	calmodulin 2	Mus musculus	0-10
2982510-5	1985	Calmodulin inhibition by methyl-CCNU was dependent on the concentration of calcium in the preincubation mixture.	Calcium	75-82	calmodulin 2	Mus musculus	0-10
2982510-6	1985	Administration of methyl-CCNU or chlorozotocin IP to CF1 mice produced a dose-dependent inhibition of calmodulin activity in the small intestine.	Semustine	18-29	calmodulin 2	Mus musculus	102-112
2982510-6	1985	Administration of methyl-CCNU or chlorozotocin IP to CF1 mice produced a dose-dependent inhibition of calmodulin activity in the small intestine.	chlorozotocin	33-46	calmodulin 2	Mus musculus	102-112
2982510-7	1985	Methyl-CCNU produced a significant decrease in intestinal calmodulin activity as early as 1 h after treatment, an effect that persisted up to 52 h. Morphologic changes in the intestinal crypt epithelial cells were evident between 27 h and 5 days after treatment, but not earlier than 27 h. Renal and testicular calmodulin activity and morphology were unaffected.	Semustine	0-11	calmodulin 2	Mus musculus	58-68
2982510-7	1985	Methyl-CCNU produced a significant decrease in intestinal calmodulin activity as early as 1 h after treatment, an effect that persisted up to 52 h. Morphologic changes in the intestinal crypt epithelial cells were evident between 27 h and 5 days after treatment, but not earlier than 27 h. Renal and testicular calmodulin activity and morphology were unaffected.	Semustine	0-11	calmodulin 2	Mus musculus	311-321
2579318-0	1985	Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists.	Bleomycin	9-18	calmodulin 2	Mus musculus	60-70
2579318-1	1985	A wide variety of structurally different calmodulin antagonists enhanced the cytotoxicity of bleomycin A2 to leukemic L1210 cells.	Bleomycin	93-105	calmodulin 2	Mus musculus	41-51
2579318-3	1985	The most potent blockers of L1210 calmodulin activity, melittin and mastoparan, were the most potent potentiators of bleomycin A2 cytotoxicity.	Bleomycin	117-129	calmodulin 2	Mus musculus	34-44
2578538-2	1985	W-13 (N-(4-aminobutyl)-5-chloro-2-naphthalenesulphonamide), a calmodulin inhibitor, reduced prolactin-induced differentiation by 80% while inhibiting insulin- and cortisol-induced RNA synthesis only 40%.	n-(4-aminobutyl)-5-chloro-2-naphthalenesulphonamide	6-57	calmodulin 2	Mus musculus	62-72
2578538-3	1985	However, tissue levels of calmodulin did not change during a 3-day culture, with or without prolactin, suggesting that the regulatory component of the calcium-calmodulin system was the intracellular calcium concentration.	Calcium	151-158	calmodulin 2	Mus musculus	159-169
6097217-1	1984	Calmodulin antagonists inhibited hormone-stimulated cyclic AMP accumulation in both cultured cells and cell lysates of mouse B16 melanoma.	Cyclic AMP	52-62	calmodulin 2	Mus musculus	0-10
6097217-4	1984	However, the rare-earth-metal ion La3+, which can mimic or replace Ca2+ in many systems, produced an immediate inhibition of agonist-stimulated adenylate cyclase activity and preincubation of particulate preparations was La3+ followed by washing with La3+-free buffer dissociated calmodulin (96% loss) from particulate preparations.	Metals	24-29	calmodulin 2	Mus musculus	280-290
6097217-4	1984	However, the rare-earth-metal ion La3+, which can mimic or replace Ca2+ in many systems, produced an immediate inhibition of agonist-stimulated adenylate cyclase activity and preincubation of particulate preparations was La3+ followed by washing with La3+-free buffer dissociated calmodulin (96% loss) from particulate preparations.	lanthanum(3+)	34-38	calmodulin 2	Mus musculus	280-290
6097217-5	1984	The loss of calmodulin from particulate preparations was associated with a decrease in agonist responsiveness (74%) and a marked change in the Ca2+-sensitivity of the enzyme, low concentrations of calcium (approx.	Calcium	197-204	calmodulin 2	Mus musculus	12-22
6488165-1	1984	Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug.	Doxorubicin	51-62	calmodulin 2	Mus musculus	0-10
6529754-1	1984	Calmodulin is a small, acidic, calcium-binding protein thought to regulate many cellular functions.	Calcium	31-38	calmodulin 2	Mus musculus	0-10
6508780-0	1984	Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.	W 7	13-63	calmodulin 2	Mus musculus	73-83
6508780-0	1984	Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.	W 7	65-68	calmodulin 2	Mus musculus	73-83
6508780-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner.	W 7	25-76	calmodulin 2	Mus musculus	2-12
6508780-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner.	W 7	78-81	calmodulin 2	Mus musculus	2-12
6541589-1	1984	A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner.	phenothiazine	141-154	calmodulin 2	Mus musculus	114-124
6541589-1	1984	A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner.	phenothiazine	141-154	calmodulin 2	Mus musculus	126-129
6541589-1	1984	A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner.	Calcium	90-97	calmodulin 2	Mus musculus	114-124
6541589-1	1984	A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner.	Calcium	90-97	calmodulin 2	Mus musculus	126-129
6488165-1	1984	Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug.	Doxorubicin	64-67	calmodulin 2	Mus musculus	0-10
6488165-1	1984	Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug.	Doxorubicin	72-75	calmodulin 2	Mus musculus	0-10
6488165-1	1984	Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug.	Doxorubicin	72-75	calmodulin 2	Mus musculus	0-10
6488165-8	1984	Results from this study indicate that in P388/DOX cells, the calmodulin inhibitor TFP is more effective with DAU than DOX, significantly less effective with ACM, and ineffective with AD32 and N-trifluoroacetyladriamycin.	Doxorubicin	46-49	calmodulin 2	Mus musculus	61-71
6488165-8	1984	Results from this study indicate that in P388/DOX cells, the calmodulin inhibitor TFP is more effective with DAU than DOX, significantly less effective with ACM, and ineffective with AD32 and N-trifluoroacetyladriamycin.	Daunorubicin	109-112	calmodulin 2	Mus musculus	61-71
6488165-8	1984	Results from this study indicate that in P388/DOX cells, the calmodulin inhibitor TFP is more effective with DAU than DOX, significantly less effective with ACM, and ineffective with AD32 and N-trifluoroacetyladriamycin.	Doxorubicin	118-121	calmodulin 2	Mus musculus	61-71
6333982-3	1984	Inhibitors of the cytoskeleton (cytochalasin B, vinblastine and colchicine) and of calmodulin (trifluoperazine) do not interfere with endocytosis at non-lethal doses.	Trifluoperazine	95-110	calmodulin 2	Mus musculus	83-93
6207062-11	1984	A CaM-dependent step in maturation was suggested since the CaM inhibitors trifluoperazine and calmidizolium inhibited GVBD in a dose-dependent manner.	Trifluoperazine	74-89	calmodulin 2	Mus musculus	2-5
6466679-7	1984	Trifluoperazine, chlorpromazine and W-7, compounds which inhibit cellular functions dependent on the Ca2+-calmodulin complex, are able to enhance the effect of external ATP.	Trifluoperazine	0-15	calmodulin 2	Mus musculus	106-116
6207062-11	1984	A CaM-dependent step in maturation was suggested since the CaM inhibitors trifluoperazine and calmidizolium inhibited GVBD in a dose-dependent manner.	Trifluoperazine	74-89	calmodulin 2	Mus musculus	59-62
6207062-11	1984	A CaM-dependent step in maturation was suggested since the CaM inhibitors trifluoperazine and calmidizolium inhibited GVBD in a dose-dependent manner.	calmidizolium	94-107	calmodulin 2	Mus musculus	2-5
6207062-11	1984	A CaM-dependent step in maturation was suggested since the CaM inhibitors trifluoperazine and calmidizolium inhibited GVBD in a dose-dependent manner.	calmidizolium	94-107	calmodulin 2	Mus musculus	59-62
6207062-17	1984	Results from these studies suggest that oocyte PDE is involved in the decrease in cAMP associated with resumption of meiosis, but that the CaM-dependent step occurs subsequent to or concurrently with the drop in cAMP.	Cyclic AMP	212-216	calmodulin 2	Mus musculus	139-142
6490356-2	1984	The biologically inactive sulphoxide derivative was not inhibitory and the efficacy of inhibition of other compounds was directly correlated (r = -0.96, p less than 0.02) with their reported affinities for calmodulin.	sulfoxide	26-36	calmodulin 2	Mus musculus	206-216
6490356-7	1984	Calmodulin was isolated from NK-enriched populations by affinity chromatography on sepharose-fluphenazine columns.	Sepharose	83-92	calmodulin 2	Mus musculus	0-10
6490356-7	1984	Calmodulin was isolated from NK-enriched populations by affinity chromatography on sepharose-fluphenazine columns.	Fluphenazine	93-105	calmodulin 2	Mus musculus	0-10
6490356-9	1984	These data are compatible with the suggestion that fluphenazine inhibits NK function by inactivating the calcium-calmodulin complex and thereby altering binding events in the target-effector interaction.	Fluphenazine	51-63	calmodulin 2	Mus musculus	113-123
6203532-1	1984	The phenothiazine derivatives, fluphenazine and trifluoperazine which are known to bind to calmodulin and to inhibit its activity, abrogate the development of both spontaneous and interferon-enhanced cytotoxicity of mouse splenic lymphocytes enriched for NK cell activity.	phenothiazine	4-17	calmodulin 2	Mus musculus	91-101
6203532-1	1984	The phenothiazine derivatives, fluphenazine and trifluoperazine which are known to bind to calmodulin and to inhibit its activity, abrogate the development of both spontaneous and interferon-enhanced cytotoxicity of mouse splenic lymphocytes enriched for NK cell activity.	Fluphenazine	31-43	calmodulin 2	Mus musculus	91-101
6203532-1	1984	The phenothiazine derivatives, fluphenazine and trifluoperazine which are known to bind to calmodulin and to inhibit its activity, abrogate the development of both spontaneous and interferon-enhanced cytotoxicity of mouse splenic lymphocytes enriched for NK cell activity.	Trifluoperazine	48-63	calmodulin 2	Mus musculus	91-101
6365929-1	1984	A Triton X-100-lysed cell system has been used to identify calmodulin on the cytoskeleton of 3T3 and transformed SV3T3 cells.	Octoxynol	2-14	calmodulin 2	Mus musculus	59-69
6324744-0	1984	Characterization of a calmodulin-dependent high-affinity cyclic AMP and cyclic GMP phosphodiesterase from male mouse germ cells.	Cyclic AMP	57-67	calmodulin 2	Mus musculus	22-32
6324744-7	1984	Reciprocal inhibition kinetics between cyclic AMP and cyclic GMP for the calmodulin-dependent form demonstrated a non-competitive inhibition between the two substrates, suggesting the presence of separate catalytic sites.	Cyclic AMP	39-49	calmodulin 2	Mus musculus	73-83
6324607-0	1984	Effects of ethanol on calmodulin levels in mouse striatum and cerebral cortex.	Ethanol	11-18	calmodulin 2	Mus musculus	22-32
6324607-2	1984	The current study investigated the role of calmodulin (CM) in mediating these effects of ethanol.	Ethanol	89-96	calmodulin 2	Mus musculus	43-53
6324607-2	1984	The current study investigated the role of calmodulin (CM) in mediating these effects of ethanol.	Ethanol	89-96	calmodulin 2	Mus musculus	55-57
6324607-4	1984	It was also shown that 24 hr following withdrawal from chronic ethanol administration, cytosolic and membrane-bound CM levels were not altered in mouse striatal tissue.	Ethanol	63-70	calmodulin 2	Mus musculus	116-118
6381970-9	1984	There was little or no difference in the levels of serum glucose between the mice injected with calmodulin antagonist (trifluoperazine, TFP) plus endotoxin and those given endotoxin alone.	Trifluoperazine	119-134	calmodulin 2	Mus musculus	96-106
6381970-12	1984	The findings suggest that there is a possibility of participation of the Ca2+-calmodulin system in carbohydrate metabolic disorders during endotoxemia and that the changes in intracellular Ca2+ may result in various metabolic disorders.	Carbohydrates	99-111	calmodulin 2	Mus musculus	78-88
6139089-9	1983	Both calcium transport and the (Ca2+ + Mg2+)-ATPase were significantly stimulated by the calcium-dependent regulatory protein calmodulin, especially when endogenous activator was removed by treatment with the calcium chelator ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid.	Calcium	5-12	calmodulin 2	Mus musculus	126-136
6139089-9	1983	Both calcium transport and the (Ca2+ + Mg2+)-ATPase were significantly stimulated by the calcium-dependent regulatory protein calmodulin, especially when endogenous activator was removed by treatment with the calcium chelator ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid.	Egtazic Acid	226-290	calmodulin 2	Mus musculus	126-136
6883309-1	1983	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), proved to have antitumor activity against solid Sarcoma-180.	W 7	25-75	calmodulin 2	Mus musculus	2-12
6883309-1	1983	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), proved to have antitumor activity against solid Sarcoma-180.	W 7	77-80	calmodulin 2	Mus musculus	2-12
6883309-3	1983	A chlorine deficient analogue, N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5), which interacts weakly with calmodulin, had no antitumor activity against solid Sarcoma-180, in a dose similar to that of W-7.	N-(6-aminohexyl)-1-naphthalenesulfonamide	31-72	calmodulin 2	Mus musculus	108-118
6520700-0	1984	Metabolic fate of ethyl O-[N-(p-carboxyphenyl)-carbamoyl] mycophenolate (CAM), a new antitumor agent, in experimental animals.	ethyl o-[n-(p-carboxyphenyl)-carbamoyl] mycophenolate	18-71	calmodulin 2	Mus musculus	73-76
6520700-1	1984	Absorption, distribution, metabolism and excretion of ethyl O-[N-(p-carboxyphenyl)-carbamoyl] mycophenolate (CAM), a new antitumor agent, was studied in mice using 14C-labeled CAM and species difference of metabolism was studied in mice, rats, guinea pigs, rabbits and dogs.	ethyl o-[n-(p-carboxyphenyl)-carbamoyl] mycophenolate	54-107	calmodulin 2	Mus musculus	109-112
6520700-9	1984	The metabolites of CAM were only mycophenolic acid (MPA) and its glucuronic acid conjugate (MPA-G) in all tested animals.	Mycophenolic Acid	33-50	calmodulin 2	Mus musculus	19-22
6520700-9	1984	The metabolites of CAM were only mycophenolic acid (MPA) and its glucuronic acid conjugate (MPA-G) in all tested animals.	Glucuronic Acid	65-80	calmodulin 2	Mus musculus	19-22
6482875-1	1984	The nature of the Ca2+ requirement of lymphocyte-mediated cytolysis (LMC) has been explored pharmacologically with a number of putative calmodulin antagonists.	LMC	69-72	calmodulin 2	Mus musculus	136-146
6736671-1	1984	Two drugs known to inhibit the action of calmodulin, prochlorperazine offP) and N-(6-aminohexyl)-5-chloro-1-napthalene sulfonamide (W7), were investigated for their ability to control cell proliferation in murine B16 melanoma cells in culture.	Prochlorperazine	53-69	calmodulin 2	Mus musculus	41-51
6736671-6	1984	FCS was found to contain calmodulin-like activity at concentrations that may be relevant to the stimulation of [3H]thymidine uptake by cells in culture.	Tritium	112-114	calmodulin 2	Mus musculus	25-35
6736671-6	1984	FCS was found to contain calmodulin-like activity at concentrations that may be relevant to the stimulation of [3H]thymidine uptake by cells in culture.	Thymidine	115-124	calmodulin 2	Mus musculus	25-35
6540180-0	1984	Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of doxorubicin (adriamycin) in resistant P388 mouse leukemia cells.	Doxorubicin	110-121	calmodulin 2	Mus musculus	31-41
6540180-0	1984	Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of doxorubicin (adriamycin) in resistant P388 mouse leukemia cells.	Doxorubicin	123-133	calmodulin 2	Mus musculus	31-41
6540180-1	1984	The relationship between potency of phenothiazine and naphthalene-sulfonamide calmodulin inhibitors and their effects on cellular levels and cytotoxic activity of doxorubicin was evaluated using the doxorubicin-sensitive and greater than 100-fold doxorubicin-resistant P388 mouse leukemia model system.	naphthalene	54-65	calmodulin 2	Mus musculus	78-88
6540180-1	1984	The relationship between potency of phenothiazine and naphthalene-sulfonamide calmodulin inhibitors and their effects on cellular levels and cytotoxic activity of doxorubicin was evaluated using the doxorubicin-sensitive and greater than 100-fold doxorubicin-resistant P388 mouse leukemia model system.	Doxorubicin	163-174	calmodulin 2	Mus musculus	78-88
6540180-1	1984	The relationship between potency of phenothiazine and naphthalene-sulfonamide calmodulin inhibitors and their effects on cellular levels and cytotoxic activity of doxorubicin was evaluated using the doxorubicin-sensitive and greater than 100-fold doxorubicin-resistant P388 mouse leukemia model system.	Doxorubicin	199-210	calmodulin 2	Mus musculus	78-88
6540180-1	1984	The relationship between potency of phenothiazine and naphthalene-sulfonamide calmodulin inhibitors and their effects on cellular levels and cytotoxic activity of doxorubicin was evaluated using the doxorubicin-sensitive and greater than 100-fold doxorubicin-resistant P388 mouse leukemia model system.	Doxorubicin	199-210	calmodulin 2	Mus musculus	78-88
6540180-2	1984	In cytotoxicity studies using cell counts based on proliferation following a 24-hr drug exposure and in survival based on colony formation in soft-agar after a 2-hr drug exposure, the calmodulin inhibitors significantly enhanced the cytotoxic effects of doxorubicin in the resistant but not parent-sensitive P388 cells.	Agar	147-151	calmodulin 2	Mus musculus	184-194
6540180-2	1984	In cytotoxicity studies using cell counts based on proliferation following a 24-hr drug exposure and in survival based on colony formation in soft-agar after a 2-hr drug exposure, the calmodulin inhibitors significantly enhanced the cytotoxic effects of doxorubicin in the resistant but not parent-sensitive P388 cells.	Doxorubicin	254-265	calmodulin 2	Mus musculus	184-194
6540180-3	1984	However, survival in soft-agar (based on colony formation) following long-term drug exposure (approximately 120 hr) revealed that the cytotoxic effects of doxorubicin were significantly increased by the calmodulin inhibitors in both sensitive and resistant P388 cells.	Agar	26-30	calmodulin 2	Mus musculus	203-213
6540180-3	1984	However, survival in soft-agar (based on colony formation) following long-term drug exposure (approximately 120 hr) revealed that the cytotoxic effects of doxorubicin were significantly increased by the calmodulin inhibitors in both sensitive and resistant P388 cells.	Doxorubicin	155-166	calmodulin 2	Mus musculus	203-213
6540180-6	1984	Among the various calmodulin inhibitors effective in enhancing cellular levels and cytotoxic effects of doxorubicin in the resistant P388 cells, chlorpromazine was approximately two-fold less potent than trifluoperazine or prochlorperazine and only N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide but not N-(4-aminobutyl)-2-naphthalenesulfonamide was active.	Doxorubicin	104-115	calmodulin 2	Mus musculus	18-28
6540180-6	1984	Among the various calmodulin inhibitors effective in enhancing cellular levels and cytotoxic effects of doxorubicin in the resistant P388 cells, chlorpromazine was approximately two-fold less potent than trifluoperazine or prochlorperazine and only N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide but not N-(4-aminobutyl)-2-naphthalenesulfonamide was active.	Chlorpromazine	145-159	calmodulin 2	Mus musculus	18-28
6585181-0	1984	[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].	Vinca Alkaloids	36-51	calmodulin 2	Mus musculus	114-124
6585181-0	1984	[Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium channel blockers and calmodulin inhibitors].	Anthracyclines	56-69	calmodulin 2	Mus musculus	114-124
6585181-6	1984	We found that calcium channel blockers and calmodulin inhibitors enhance the intracellular level of vincristine and adriamycin in tumor cells, especially in drug-resistant mouse and human tumor cells by inhibiting their outward transport.	Vincristine	100-111	calmodulin 2	Mus musculus	43-53
6585181-6	1984	We found that calcium channel blockers and calmodulin inhibitors enhance the intracellular level of vincristine and adriamycin in tumor cells, especially in drug-resistant mouse and human tumor cells by inhibiting their outward transport.	Doxorubicin	116-126	calmodulin 2	Mus musculus	43-53
6421505-0	1984	Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.	W 7	39-88	calmodulin 2	Mus musculus	92-102
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	W 7	25-75	calmodulin 2	Mus musculus	2-12
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	W 7	77-80	calmodulin 2	Mus musculus	2-12
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	teleocidins	127-137	calmodulin 2	Mus musculus	2-12
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	7,12-dimethylbenz[a	187-206	calmodulin 2	Mus musculus	2-12
6421505-1	1984	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene.	anthracene	207-217	calmodulin 2	Mus musculus	2-12
6150680-5	1984	Phenytoin, carbamazepine, and the benzodiazepines inhibit Ca2+ -calmodulin-regulated protein phosphorylation and neurotransmitter release by synaptic vesicles.	Phenytoin	0-9	calmodulin 2	Mus musculus	64-74
6150680-5	1984	Phenytoin, carbamazepine, and the benzodiazepines inhibit Ca2+ -calmodulin-regulated protein phosphorylation and neurotransmitter release by synaptic vesicles.	Carbamazepine	11-24	calmodulin 2	Mus musculus	64-74
6150680-5	1984	Phenytoin, carbamazepine, and the benzodiazepines inhibit Ca2+ -calmodulin-regulated protein phosphorylation and neurotransmitter release by synaptic vesicles.	Benzodiazepines	34-49	calmodulin 2	Mus musculus	64-74
6427469-11	1984	The anti-calmodulin drugs trifluoperazine, pimozide, flupentixol, and chlorpromazine blocked the volume response.	Trifluoperazine	26-41	calmodulin 2	Mus musculus	9-19
6427469-11	1984	The anti-calmodulin drugs trifluoperazine, pimozide, flupentixol, and chlorpromazine blocked the volume response.	Pimozide	43-51	calmodulin 2	Mus musculus	9-19
6427469-11	1984	The anti-calmodulin drugs trifluoperazine, pimozide, flupentixol, and chlorpromazine blocked the volume response.	Flupenthixol	53-64	calmodulin 2	Mus musculus	9-19
6427469-11	1984	The anti-calmodulin drugs trifluoperazine, pimozide, flupentixol, and chlorpromazine blocked the volume response.	Chlorpromazine	70-84	calmodulin 2	Mus musculus	9-19
6605252-0	1983	Calcium control of actin-myosin based contraction in triton models of mouse 3T3 fibroblasts is mediated by the myosin light chain kinase (MLCK)-calmodulin complex.	Calcium	0-7	calmodulin 2	Mus musculus	144-154
6605252-7	1983	The combined results indicate that contractility of non-muscle cellular models is controlled by calmodulin-dependent MLCK acting on the actin-myosin-containing microfilaments with a calcium control exerted in the phosphorylation step of myosin.	Calcium	182-189	calmodulin 2	Mus musculus	96-106
6861140-0	1983	Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.	Doxorubicin	30-40	calmodulin 2	Mus musculus	75-85
6861140-0	1983	Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.	Trifluoperazine	96-111	calmodulin 2	Mus musculus	75-85
6861140-2	1983	In this study, the effect of the calmodulin inhibitor trifluoperazine on the cellular accumulation, retention, and cytotoxic effects of ADR in ADR-sensitive (P388/S) and ADR-resistant (P388/R) P388 mouse leukemia cells was determined.	Trifluoperazine	54-69	calmodulin 2	Mus musculus	33-43
6307925-8	1983	Both normal and ionophore-enhanced lysis were also inhibited by the phenothiazines chlorpromazine and trifluoperazine, which block the activity of calmodulin.	phenothiazines chlorpromazine	68-97	calmodulin 2	Mus musculus	147-157
6307925-8	1983	Both normal and ionophore-enhanced lysis were also inhibited by the phenothiazines chlorpromazine and trifluoperazine, which block the activity of calmodulin.	Trifluoperazine	102-117	calmodulin 2	Mus musculus	147-157
6307925-9	1983	A more specific calmodulin activity inhibitor, W13, was also shown to profoundly inhibit cytotoxicity induced by A23187.	Calcimycin	113-119	calmodulin 2	Mus musculus	16-26
6466679-7	1984	Trifluoperazine, chlorpromazine and W-7, compounds which inhibit cellular functions dependent on the Ca2+-calmodulin complex, are able to enhance the effect of external ATP.	Chlorpromazine	17-31	calmodulin 2	Mus musculus	106-116
6466679-7	1984	Trifluoperazine, chlorpromazine and W-7, compounds which inhibit cellular functions dependent on the Ca2+-calmodulin complex, are able to enhance the effect of external ATP.	Adenosine Triphosphate	169-172	calmodulin 2	Mus musculus	106-116
6466679-9	1984	Calmodulin antagonists and low concentrations of external ATP increased membrane permeability to Na+ and K+ as was previously shown for permeabilization with ATP alone.	Adenosine Triphosphate	158-161	calmodulin 2	Mus musculus	0-10
6604166-0	1983	Receptor capping in mouse T-lymphoma cells: a Ca2+ and calmodulin-stimulated ATP-dependent process.	Adenosine Triphosphate	77-80	calmodulin 2	Mus musculus	55-65
6864439-0	1983	Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine.	Vincristine	43-54	calmodulin 2	Mus musculus	102-112
6864439-0	1983	Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine.	Vincristine	58-69	calmodulin 2	Mus musculus	102-112
6864439-0	1983	Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine.	Clomipramine	123-135	calmodulin 2	Mus musculus	102-112
6864439-1	1983	Clomipramine, which is used as antidepressant and possesses calmodulin inhibitory activity, circumvented partly the vincristine resistance in vivo.	Clomipramine	0-12	calmodulin 2	Mus musculus	60-70
6864439-1	1983	Clomipramine, which is used as antidepressant and possesses calmodulin inhibitory activity, circumvented partly the vincristine resistance in vivo.	Vincristine	116-127	calmodulin 2	Mus musculus	60-70
6196336-1	1983	Calmodulin is a well-known calcium-binding protein which is ubiquitous in the plant and animal kingdoms and regulates many cellular processes.	Calcium	27-34	calmodulin 2	Mus musculus	0-10
6294249-4	1983	Leucine enkephalin and D-Ala2-methionine enkephalinamide decrease the amount of membrane-bound calmodulin in the NC108-15 cells in a time- and dose-dependent manner, whereas the opiate antagonists naloxone and levallorphan have an opposite effect.	Naloxone	197-205	calmodulin 2	Mus musculus	95-105
6294249-4	1983	Leucine enkephalin and D-Ala2-methionine enkephalinamide decrease the amount of membrane-bound calmodulin in the NC108-15 cells in a time- and dose-dependent manner, whereas the opiate antagonists naloxone and levallorphan have an opposite effect.	Levallorphan	210-222	calmodulin 2	Mus musculus	95-105
6294249-7	1983	The alteration in the amount of membrane-bound calmodulin after a short incubation (15 min) with the enkephalins or with naloxone is reflected as an opposite change in the amount of calmodulin in the cell cytosol.	Naloxone	121-129	calmodulin 2	Mus musculus	47-57
6294249-7	1983	The alteration in the amount of membrane-bound calmodulin after a short incubation (15 min) with the enkephalins or with naloxone is reflected as an opposite change in the amount of calmodulin in the cell cytosol.	Naloxone	121-129	calmodulin 2	Mus musculus	182-192
6572895-0	1983	Characterization of a calmodulin-binding protein that is deficient in trifluoperazine-resistant variants of the macrophage-like cell line J774.	Trifluoperazine	70-85	calmodulin 2	Mus musculus	22-32
6294249-9	1983	Modulation of the intracellular distribution of calmodulin by opioid peptides and alkaloids may control the activity of various membrane-bound and cytosolic systems that are calmodulin- and/or calcium-dependent.	Calcium	193-200	calmodulin 2	Mus musculus	48-58
6572895-1	1983	A calmodulin-binding protein is present in extracts of the macrophage-like mouse cell line J774 and in extracts of thioglycollate-stimulated mouse peritoneal macrophages; it is deficient in variants of J774 resistant to trifluoperazine and in resident peritoneal macrophages.	Thioglycolates	115-129	calmodulin 2	Mus musculus	2-12
6572895-1	1983	A calmodulin-binding protein is present in extracts of the macrophage-like mouse cell line J774 and in extracts of thioglycollate-stimulated mouse peritoneal macrophages; it is deficient in variants of J774 resistant to trifluoperazine and in resident peritoneal macrophages.	Trifluoperazine	220-235	calmodulin 2	Mus musculus	2-12
6572895-3	1983	The protein has an apparent native Mr of 125,000-150,000 and binds calmodulin in a calcium-dependent manner with a Kd of 20 nM.	Calcium	83-90	calmodulin 2	Mus musculus	67-77
6572895-5	1983	Its sedimentation constant in glycerol gradients containing calmodulin was dependent upon the relative concentrations of calmodulin and the calmodulin-binding protein.	Glycerol	30-38	calmodulin 2	Mus musculus	60-70
6572895-5	1983	Its sedimentation constant in glycerol gradients containing calmodulin was dependent upon the relative concentrations of calmodulin and the calmodulin-binding protein.	Glycerol	30-38	calmodulin 2	Mus musculus	121-131
6572895-5	1983	Its sedimentation constant in glycerol gradients containing calmodulin was dependent upon the relative concentrations of calmodulin and the calmodulin-binding protein.	Glycerol	30-38	calmodulin 2	Mus musculus	121-131
6814940-2	1982	When the recompaction medium contained trifluoperazine (TFP)(0.05 mM), an inhibitor of the calcium-dependent protein calmodulin, the embryos failed to recompact.	Trifluoperazine	39-54	calmodulin 2	Mus musculus	117-127
7127307-0	1982	Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.	Vincristine	26-37	calmodulin 2	Mus musculus	138-148
7127307-0	1982	Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.	Doxorubicin	42-52	calmodulin 2	Mus musculus	138-148
7127307-1	1982	Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport.	Vincristine	87-98	calmodulin 2	Mus musculus	29-39
7127307-1	1982	Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport.	Doxorubicin	103-113	calmodulin 2	Mus musculus	29-39
7127307-1	1982	Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport.	Vincristine	117-128	calmodulin 2	Mus musculus	29-39
7127307-1	1982	Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport.	Doxorubicin	134-144	calmodulin 2	Mus musculus	29-39
6814940-2	1982	When the recompaction medium contained trifluoperazine (TFP)(0.05 mM), an inhibitor of the calcium-dependent protein calmodulin, the embryos failed to recompact.	Calcium	91-98	calmodulin 2	Mus musculus	117-127
7274650-1	1981	A newly synthesized mycophenolic acid (MPA) derivative, ethyl O-[N-(p-carboxyphenyl)-carbamoyl]-mycophenolate (CAM, NSC-297879D) was tested for antitumor activity, when given orally, against transplantable murine tumors.	cafestol palmitate	111-114	calmodulin 2	Mus musculus	62-109
6297099-4	1982	Since silica and carrageenan are known to reduce macrophage function, their effect on CAM granulocyte colony formation was tested.	Carrageenan	17-28	calmodulin 2	Mus musculus	86-89
6297099-8	1982	CAM produced in one mouse and exposed to carrageenan or silica in situ for 24 h before being transferred to sublethally irradiated recipients and seeded by injection of marrow cells had control levels of granulocytic colonies.	Carrageenan	41-52	calmodulin 2	Mus musculus	0-3
6297099-8	1982	CAM produced in one mouse and exposed to carrageenan or silica in situ for 24 h before being transferred to sublethally irradiated recipients and seeded by injection of marrow cells had control levels of granulocytic colonies.	Silicon Dioxide	56-62	calmodulin 2	Mus musculus	0-3
6297099-9	1982	Likewise, CAM produced in one mouse, removed, incubated in vitro with carrageenan or silica, carefully rinsed and transferred to sublethally irradiated recipients and seeded with marrow cells were able to support control levels of colony formation.	Carrageenan	70-81	calmodulin 2	Mus musculus	10-13
6297099-9	1982	Likewise, CAM produced in one mouse, removed, incubated in vitro with carrageenan or silica, carefully rinsed and transferred to sublethally irradiated recipients and seeded with marrow cells were able to support control levels of colony formation.	Silicon Dioxide	85-91	calmodulin 2	Mus musculus	10-13
6270154-1	1981	TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells.	Steroids	87-94	calmodulin 2	Mus musculus	179-189
6270154-1	1981	TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells.	Steroids	87-94	calmodulin 2	Mus musculus	225-235
6270154-1	1981	TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells.	Trifluoperazine	135-150	calmodulin 2	Mus musculus	179-189
6270154-1	1981	TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells.	Trifluoperazine	135-150	calmodulin 2	Mus musculus	225-235
6270154-3	1981	When calmodulin is introduced into the cells via liposomes, steroid synthesis is slightly stimulated.	Steroids	60-67	calmodulin 2	Mus musculus	5-15
6270154-4	1981	When calmodulin extensively dialyzed against EGTA, this stimulation is abolished.	Egtazic Acid	45-49	calmodulin 2	Mus musculus	5-15
6270154-6	1981	However, when both calmodulin and Ca(2+) are introduced via liposomes (either in separate liposomes or in the same liposomes), steroid synthesis is stimulated.	Steroids	127-134	calmodulin 2	Mus musculus	19-29
6270154-8	1981	Calmodulin and Ca(2+) presented together in liposomes to the cells stimulate transport of cholesterol to mitochondria, and side-chain cleavage activity is greater in mitochondria isolated from cells previously fused with liposomes containing calmodulin and Ca(2+) than in mitochondria from cells fused with liposomes containing buffer only.	Cholesterol	90-101	calmodulin 2	Mus musculus	0-10
6270154-9	1981	These observations suggest that calmodulin may be involved in regulating the transport of cholesterol to mitochondria, a process which is stimulated by ACTH and dibutyryl cyclic AMP and which may account, at least in part, for the increase in steroid synthesis produced by these agents.	Cholesterol	90-101	calmodulin 2	Mus musculus	32-42
6270154-9	1981	These observations suggest that calmodulin may be involved in regulating the transport of cholesterol to mitochondria, a process which is stimulated by ACTH and dibutyryl cyclic AMP and which may account, at least in part, for the increase in steroid synthesis produced by these agents.	Bucladesine	161-181	calmodulin 2	Mus musculus	32-42
6270154-9	1981	These observations suggest that calmodulin may be involved in regulating the transport of cholesterol to mitochondria, a process which is stimulated by ACTH and dibutyryl cyclic AMP and which may account, at least in part, for the increase in steroid synthesis produced by these agents.	Steroids	243-250	calmodulin 2	Mus musculus	32-42
6266359-0	1981	Opiate agonists inhibit noradrenaline release via opiate B-receptors and N-cyclopropylmethylnorazidomorphine (CAM) blocks electrically evoked contractions via histamine in the mouse vas deferens.	Histamine	159-168	calmodulin 2	Mus musculus	73-114
7274650-1	1981	A newly synthesized mycophenolic acid (MPA) derivative, ethyl O-[N-(p-carboxyphenyl)-carbamoyl]-mycophenolate (CAM, NSC-297879D) was tested for antitumor activity, when given orally, against transplantable murine tumors.	Mycophenolic Acid	20-37	calmodulin 2	Mus musculus	62-109
7274650-1	1981	A newly synthesized mycophenolic acid (MPA) derivative, ethyl O-[N-(p-carboxyphenyl)-carbamoyl]-mycophenolate (CAM, NSC-297879D) was tested for antitumor activity, when given orally, against transplantable murine tumors.	Mycophenolic Acid	39-42	calmodulin 2	Mus musculus	62-109
6260201-8	1981	From sucrose gradient studies we demonstrated that in the presence of Ca2+ the amount of calmodulin bound to phosphorylase kinase was enhanced, compared to the control in the presence of EGTA.	Sucrose	5-12	calmodulin 2	Mus musculus	89-99
6260201-8	1981	From sucrose gradient studies we demonstrated that in the presence of Ca2+ the amount of calmodulin bound to phosphorylase kinase was enhanced, compared to the control in the presence of EGTA.	Egtazic Acid	187-191	calmodulin 2	Mus musculus	89-99
428519-3	1979	Labelling of the cells with activated charcoal or 3H-thymidine gave evidence of their invasion into the CAM mesoderm, where they induced the formation of new capillaries.	Charcoal	28-46	calmodulin 2	Mus musculus	104-107
7410833-2	1980	Calmodulin, a ubiquitous small acidic Ca-binding protein, appears to link the intracellular second messengers--Ca++ and the cyclic nucleotides--through its ability to regulate numerous central metabolic enzymatic activities.	Nucleotides, Cyclic	124-142	calmodulin 2	Mus musculus	0-10
428519-3	1979	Labelling of the cells with activated charcoal or 3H-thymidine gave evidence of their invasion into the CAM mesoderm, where they induced the formation of new capillaries.	3h-thymidine	50-62	calmodulin 2	Mus musculus	104-107
33790404-5	2021	Surprisingly, either genetic (by V3599K substitution in RyR2) or pharmacological (by dantrolene) enhancement of CaM binding to RyR2 reversed almost completely the aforementioned AD-related phenotypes, except for Abeta accumulation.	Dantrolene	85-95	calmodulin 2	Mus musculus	112-115
33951696-12	2021	miR-338-3p directly targeted CALM2 to inhibit OGD-induced damage in AC16 cells.	mir-338-3p	0-10	calmodulin 2	Mus musculus	29-34
33293457-4	2021	Taking advantage of a model in which RBs can be stimulated by expressed channelrhodopsin-2 (ChR2) to avoid dialysis of the presynaptic terminal, we found that inhibition of CaM dramatically decreased evoked release by inhibition of presynaptic Ca channels while at the same time potentiating both Ca2+-dependent and Ca2+-independent spontaneous release.	Rubidium	37-40	calmodulin 2	Mus musculus	173-176
32970800-3	2021	Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for TEM.	Calcium	36-43	calmodulin 2	Mus musculus	12-22
32970800-3	2021	Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for TEM.	Calcium	36-43	calmodulin 2	Mus musculus	24-27
32970800-4	2021	In the presence of calcium, CaM binds endothelial calcium/calmodulin kinase IIdelta (CaMKIIdelta).	Calcium	19-26	calmodulin 2	Mus musculus	28-31
32970800-4	2021	In the presence of calcium, CaM binds endothelial calcium/calmodulin kinase IIdelta (CaMKIIdelta).	Calcium	19-26	calmodulin 2	Mus musculus	58-68
32970800-7	2021	These findings highlight novel roles for endothelial CaM and CaMKIIdelta in transducing the spatiotemporally restricted calcium signaling required for TEM.	Calcium	120-127	calmodulin 2	Mus musculus	53-56
33890345-0	2021	Calmodulin is involved in the occurrence of extracellular Ca2+ -dependent full-type hyperactivation in boar ejaculated spermatozoa incubated with cyclic AMP analogs.	Cyclic AMP	146-156	calmodulin 2	Mus musculus	0-10
32522522-0	2020	Ca2+/CaM/CaMK signaling is involved in cadmium-induced osteoclast differentiation.	Cadmium	39-46	calmodulin 2	Mus musculus	5-8
32522522-8	2020	Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway.	Calcium	44-51	calmodulin 2	Mus musculus	85-95
32522522-8	2020	Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway.	Calcium	44-51	calmodulin 2	Mus musculus	97-100
32522522-8	2020	Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway.	Calcium	44-51	calmodulin 2	Mus musculus	102-112
32522522-10	2020	Overall, we conclude that Cd activates the CaM/CaMK/NFATc1 pathway and regulates osteoclast differentiation by increasing intracellular calcium concentration.	Cadmium	26-28	calmodulin 2	Mus musculus	43-46
31628181-0	2019	Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses.	Calcium	41-48	calmodulin 2	Mus musculus	21-31
31635807-2	2020	We previously showed that dantrolene, a specific agent for the treatment of malignant hyperthermia, inhibits Ca2+ leakage from the RyR2 by correcting the defective inter-domain interaction between the N-terminal (1-619 amino acids) and central (2000-2500 amino acids) domains of the RyR2 and allosterically enhancing the binding affinity of calmodulin to the RyR2 in diseased hearts.	Dantrolene	26-36	calmodulin 2	Mus musculus	341-351
31635807-6	2020	In the presence of dantrolene, the occurrence of both Ca2+ sparks and spontaneous Ca2+ transients was inhibited, which was associated with enhanced calmodulin binding affinity to the RyR2.	Dantrolene	19-29	calmodulin 2	Mus musculus	148-158
31635807-6	2020	In the presence of dantrolene, the occurrence of both Ca2+ sparks and spontaneous Ca2+ transients was inhibited, which was associated with enhanced calmodulin binding affinity to the RyR2.	Calcium	54-58	calmodulin 2	Mus musculus	148-158
31635807-6	2020	In the presence of dantrolene, the occurrence of both Ca2+ sparks and spontaneous Ca2+ transients was inhibited, which was associated with enhanced calmodulin binding affinity to the RyR2.	Calcium	82-86	calmodulin 2	Mus musculus	148-158
31628181-7	2019	Inhibition of slow endocytosis in PKC or calmodulin 2 knock-out hippocampal synapses was rescued by overexpressing wild-type PKC or calmodulin, but not calcium-binding-deficient PKC or calmodulin mutant, respectively, suggesting that calcium stimulates endocytosis by binding with its calcium sensor PKC and calmodulin.	Calcium	234-241	calmodulin 2	Mus musculus	41-53
31628181-7	2019	Inhibition of slow endocytosis in PKC or calmodulin 2 knock-out hippocampal synapses was rescued by overexpressing wild-type PKC or calmodulin, but not calcium-binding-deficient PKC or calmodulin mutant, respectively, suggesting that calcium stimulates endocytosis by binding with its calcium sensor PKC and calmodulin.	Calcium	234-241	calmodulin 2	Mus musculus	41-53
31628181-8	2019	PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization.	Calcium	41-48	calmodulin 2	Mus musculus	8-20
31628181-0	2019	Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses.	Calcium	61-68	calmodulin 2	Mus musculus	21-31
31628181-8	2019	PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization.	Calcium	41-48	calmodulin 2	Mus musculus	8-18
31628181-8	2019	PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization.	Calcium	159-166	calmodulin 2	Mus musculus	8-20
31628181-3	2019	Here, we examined two calcium binding proteins, protein kinase C (PKC) and calmodulin.	Calcium	22-29	calmodulin 2	Mus musculus	75-85
31628181-8	2019	PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization.	Calcium	159-166	calmodulin 2	Mus musculus	8-18
31628181-4	2019	Whether PKC is involved in endocytosis was unclear; whether calmodulin acts as a calcium sensor for endocytosis was neither clear, although calmodulin involvement in endocytosis had been suggested.	Calcium	81-88	calmodulin 2	Mus musculus	60-70
31628181-13	2019	Using genetic tools together with capacitance measurements, optical imaging and electron microscopy, we identified two calcium sensors, including protein kinase C (alpha and beta isoforms) and calmodulin, for the most commonly observed forms of endocytosis: slow, rapid, and bulk.	Calcium	119-126	calmodulin 2	Mus musculus	193-203
31266820-6	2019	RESULTS: Both lobes of CaM helped induce CDI.	1,1'-Carbonyldiimidazole	41-44	calmodulin 2	Mus musculus	23-26
30680583-6	2019	In addition, our results demonstrate that obtustatin inhibits FGF2-induced angiogenesis in the CAM assay.	obtustatin	42-52	calmodulin 2	Mus musculus	95-98
30296477-8	2019	Like STIM1 knockdown, application of the calmodulin inhibitor W7 lowered cAMP levels, further indicating that STIM1 regulates AC3 via Ca2+ We conclude that the high levels of STIM1 in ADPKD cells play a role in supporting cyst growth and promoting high cAMP levels and an increased release of Ca2+ from the ER.	Cyclic AMP	73-77	calmodulin 2	Mus musculus	41-51
30296477-8	2019	Like STIM1 knockdown, application of the calmodulin inhibitor W7 lowered cAMP levels, further indicating that STIM1 regulates AC3 via Ca2+ We conclude that the high levels of STIM1 in ADPKD cells play a role in supporting cyst growth and promoting high cAMP levels and an increased release of Ca2+ from the ER.	Cyclic AMP	253-257	calmodulin 2	Mus musculus	41-51
30359562-4	2018	We found that angiotensin II (AngII) or phenylephrine (PE) both cause CaM to dissociate from the RyR2 and translocate to the nucleus.	Phenylephrine	55-57	calmodulin 2	Mus musculus	70-73
30890031-3	2019	The aim of the current study was to assess whether the calcium/calmodulin pathway is a principal target of environmentally relevant Pb during pro-inflammatory activation in a RAW 264.7 macrophage cell line.	Calcium	55-62	calmodulin 2	Mus musculus	63-73
30890031-3	2019	The aim of the current study was to assess whether the calcium/calmodulin pathway is a principal target of environmentally relevant Pb during pro-inflammatory activation in a RAW 264.7 macrophage cell line.	Lead	132-134	calmodulin 2	Mus musculus	63-73
30359562-4	2018	We found that angiotensin II (AngII) or phenylephrine (PE) both cause CaM to dissociate from the RyR2 and translocate to the nucleus.	Phenylephrine	40-53	calmodulin 2	Mus musculus	70-73
30359562-6	2018	Dantrolene dramatically reduced AngII- and PE-induced nuclear CaM accumulation.	Dantrolene	0-10	calmodulin 2	Mus musculus	62-65
30359562-7	2018	Conversely, suramin enhanced nuclear CaM accumulation.	Suramin	12-19	calmodulin 2	Mus musculus	37-40
30233307-5	2018	Calmodulin in microglia, and calmodulin and NCS1 in neurons, are necessary for NMDA-induced MAP kinase pathway activation.	N-Methylaspartate	79-83	calmodulin 2	Mus musculus	0-10
30040045-6	2018	Expression of Mel-CAM and L1-CAM was upregulated after low-dose photon exposure, but decreased with dose, especially after carbon-ion treatment.	Carbon	123-129	calmodulin 2	Mus musculus	18-21
30233307-5	2018	Calmodulin in microglia, and calmodulin and NCS1 in neurons, are necessary for NMDA-induced MAP kinase pathway activation.	N-Methylaspartate	79-83	calmodulin 2	Mus musculus	29-39
29267844-6	2018	Flow cytometry results revealed that intracellular calcium (Ca2+) level was changed by nalmefene, western blot analysis showed that nalmefene decreased calmodulin expression and calcium/calmodulin dependent protein kinases II (CaMK II) phosphorylation, thus inhibiting the serine/threonine kinase (AKT)-glycogen synthase kinase-3beta (GSK-3beta) pathway.	nalmefene	132-141	calmodulin 2	Mus musculus	152-162
30101473-3	2018	Using synthetic peptides, it has been shown that CaM binds to two additional regions within the RyR1, specifically residues 1975-1999 and 4295-4325 (CaMBD1 and CaMBD3, respectively).	Peptides	16-24	calmodulin 2	Mus musculus	49-52
30101473-5	2018	Our goals were: (1) to establish whether S100A1 binds to synthetic peptides containing CaMBD1 and CaMBD3 using isothermal calorimetry (ITC), and (2) to identify whether S100A1 and CaM modulate RyR1 Ca2+ release activation via sites other than CaMBD2 in RyR1 in its native cellular context.	Peptides	67-75	calmodulin 2	Mus musculus	87-90
29720499-8	2018	During catecholamine stimulation with isoproterenol, T-CaM reduced isoproterenol-promoted diastolic Ca waves in isolated CPVT cardiomyocytes.	Catecholamines	7-20	calmodulin 2	Mus musculus	55-58
29720499-8	2018	During catecholamine stimulation with isoproterenol, T-CaM reduced isoproterenol-promoted diastolic Ca waves in isolated CPVT cardiomyocytes.	Isoproterenol	38-51	calmodulin 2	Mus musculus	55-58
29720499-8	2018	During catecholamine stimulation with isoproterenol, T-CaM reduced isoproterenol-promoted diastolic Ca waves in isolated CPVT cardiomyocytes.	Isoproterenol	67-80	calmodulin 2	Mus musculus	55-58
29267844-6	2018	Flow cytometry results revealed that intracellular calcium (Ca2+) level was changed by nalmefene, western blot analysis showed that nalmefene decreased calmodulin expression and calcium/calmodulin dependent protein kinases II (CaMK II) phosphorylation, thus inhibiting the serine/threonine kinase (AKT)-glycogen synthase kinase-3beta (GSK-3beta) pathway.	nalmefene	132-141	calmodulin 2	Mus musculus	186-196
29267844-8	2018	In conclusion, the anti-tumor effect of nalmefene may be achieved by inhibiting opioid receptor and down-regulating calmodulin expression and CaMK II phosphorylation, thus inhibiting AKT-GSK-3beta pathway and the glycolysis of CT26 cells.	nalmefene	40-49	calmodulin 2	Mus musculus	116-126
28253589-0	2017	[Effect of zoledronate on protein interaction between Ca(2+)/calmodulin-dependent protein kinaseII and calmodulin and expression of downstream genes during osteoclast differentiation].	Zoledronic Acid	11-22	calmodulin 2	Mus musculus	61-71
28253589-0	2017	[Effect of zoledronate on protein interaction between Ca(2+)/calmodulin-dependent protein kinaseII and calmodulin and expression of downstream genes during osteoclast differentiation].	Zoledronic Acid	11-22	calmodulin 2	Mus musculus	103-113
28253589-1	2017	Objective: To investigate the effect of zoledronate on protein interaction between Ca(2+)/calmodulin-dependent protein kinaseII(CaMKII) and calmodulin and protein expression of nuclear factor of activation of T cells-1 (NFATc1) and tartrate resistant acid phosphatase (TRAP) during osteoclast differentiation.	Zoledronic Acid	40-51	calmodulin 2	Mus musculus	90-100
28253589-11	2017	Conclusions: Zoledronate could significantly inhibit protein-binding between CaMKII and calmodulin and down-regulate protein level of NFATc1 and TRAP.	Zoledronic Acid	13-24	calmodulin 2	Mus musculus	88-98
27833566-11	2016	The emerging hypothesis indicates that GAP43 interacts with calmodulin to indirectly modulate the activities of dihydropyridine and ryanodine Ca2+ channels.	1,4-dihydropyridine	112-127	calmodulin 2	Mus musculus	60-70
27655403-9	2016	Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin.	Dantrolene	0-10	calmodulin 2	Mus musculus	99-109
28062709-0	2017	Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R.	Trifluoperazine	0-15	calmodulin 2	Mus musculus	90-100
28062709-7	2017	Unlike caffeine, TFP triggers massive and irreversible release of Ca2+ from intracellular stores by IP3R subtype 1 and 2 by directly interacting at the TFP-binding site of a Ca2+-binding protein, calmodulin subtype 2 (CaM2).	cam2	218-222	calmodulin 2	Mus musculus	196-206
27750011-0	2016	Endogenous Polysialic Acid Based Micelles for Calmodulin Antagonist Delivery against Vascular Dementia.	polysialic acid	11-26	calmodulin 2	Mus musculus	46-56
27750011-2	2016	Here, a micelle based on polysialic acid (PSA), which is a hydrophilic and endogenous carbohydrate polymer, was designed to deliver calmodulin antagonist for therapy of vascular dementia.	polysialic acid	25-40	calmodulin 2	Mus musculus	132-142
27750011-2	2016	Here, a micelle based on polysialic acid (PSA), which is a hydrophilic and endogenous carbohydrate polymer, was designed to deliver calmodulin antagonist for therapy of vascular dementia.	polysialic acid	42-45	calmodulin 2	Mus musculus	132-142
27750011-2	2016	Here, a micelle based on polysialic acid (PSA), which is a hydrophilic and endogenous carbohydrate polymer, was designed to deliver calmodulin antagonist for therapy of vascular dementia.	Carbohydrates	86-98	calmodulin 2	Mus musculus	132-142
27750011-7	2016	The decrease of hippocampal phospho-CaMKII (Thr286/287) and phospho-synapsin I (Ser603) was partially restored in rUCCAO mice following calmodulin antagonist loaded PSA-ODA micelle treatment.	stearylamine	169-172	calmodulin 2	Mus musculus	136-146
25597298-8	2015	The EGTA effect in nominal zero Ca(2+) media was mimicked by two calmodulin antagonists, W7 and calmidazolium, and by the calcineurin inhibitor cyclosporine A.	Egtazic Acid	4-8	calmodulin 2	Mus musculus	65-75
26644468-2	2016	Previously we demonstrated that the micronutrient selenium induces a phenotypic switch in macrophage activation from a classically activated (pro-inflammatory; M1/CAM) toward an alternatively activated (anti-inflammatory; M2/AAM) phenotype, where cyclooxygenase (COX)-dependent cyclopentenone prostaglandin J2 (15d-PGJ2) plays a key role.	Selenium	50-58	calmodulin 2	Mus musculus	163-166
27264040-5	2016	PG treatment resulted in reduction of the beating ratio to 60.45+-1.54% from 92.17+-2.98% in normal differentiation, reduced transcripts of heart morphogenesis and Ca(2+) binding-related genes in the next generation sequencing data and significantly decreased expression levels of Ca(2+)/contraction-related genes including Ryr2, Calm2, Trpv2, and Mylk3, the intracellular Ca(2+) level, and the beating frequency.	Progesterone	0-2	calmodulin 2	Mus musculus	330-335
26864654-5	2016	CaM inhibitor N-[4-aminobutyl]-5-chloro-2-naphthalenesulfonamide hydrochloride (W13) suppressed the mGluR1/5-stimulated activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p70-S6 kinase 1 (S6K1) in hippocampal neurons.	n-[4-aminobutyl]-5-chloro-2-naphthalenesulfonamide hydrochloride	14-78	calmodulin 2	Mus musculus	0-3
26864654-5	2016	CaM inhibitor N-[4-aminobutyl]-5-chloro-2-naphthalenesulfonamide hydrochloride (W13) suppressed the mGluR1/5-stimulated activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p70-S6 kinase 1 (S6K1) in hippocampal neurons.	N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	80-83	calmodulin 2	Mus musculus	0-3
25842244-3	2016	Phosphorylation of eEF2 by Ca/calmodulin-dependent eEF2 kinase reduces the activity of eEF2, and this is prevented by a commonly used eEF2 kinase inhibitor, NH125.	NH 125	157-162	calmodulin 2	Mus musculus	30-40
26184176-7	2015	The results showed that 3 weeks of dietary omega-3 fatty acid supplementation improved cognitive performance along with the up-regulation of alpha-synuclein, calmodulin and transthyretin genes expression.	Fatty Acids, Omega-3	43-61	calmodulin 2	Mus musculus	158-168
25822458-3	2015	However, CaM has been suggested to control the translational assembly of the enzyme as well, particularly in helping its inducible isoform, iNOS assume a stable, heme-replete, dimeric and active form.	Heme	162-166	calmodulin 2	Mus musculus	9-12
25920678-0	2015	Essential Role of Calmodulin in RyR Inhibition by Dantrolene.	Dantrolene	50-60	calmodulin 2	Mus musculus	18-28
25920678-4	2015	Here we test the hypothesis that calmodulin (CaM), a physiologic RyR binding partner that is lost during incorporation into lipid bilayers, is required for dantrolene inhibition of RyR channels.	Dantrolene	156-166	calmodulin 2	Mus musculus	33-43
25920678-4	2015	Here we test the hypothesis that calmodulin (CaM), a physiologic RyR binding partner that is lost during incorporation into lipid bilayers, is required for dantrolene inhibition of RyR channels.	Dantrolene	156-166	calmodulin 2	Mus musculus	45-48
25822458-7	2015	Moreover, such CaM-free iNOS has similar flavin content and reductase activity as iNOS co-expressed with CaM, suggesting that CaM may not be as much required for the functional assembly of the iNOS reductase domain as its oxygenase domain.	4,6-dinitro-o-cresol	41-47	calmodulin 2	Mus musculus	15-18
25389288-5	2015	In this study, we identify calmodulin (CaM), a known transducer of the calcium signal, as the first positive regulator of CAPN3 autolytic activity.	Calcium	71-78	calmodulin 2	Mus musculus	27-37
25389288-5	2015	In this study, we identify calmodulin (CaM), a known transducer of the calcium signal, as the first positive regulator of CAPN3 autolytic activity.	Calcium	71-78	calmodulin 2	Mus musculus	39-42
25437912-0	2015	Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling.	Calcium	71-78	calmodulin 2	Mus musculus	37-47
24853690-3	2014	Thus, the cAMP cascade mediator Ca(2+)-dependent calmodulin (CaM) has been strongly implicated in the central effects of ethanol.	Cyclic AMP	10-14	calmodulin 2	Mus musculus	49-59
24853690-3	2014	Thus, the cAMP cascade mediator Ca(2+)-dependent calmodulin (CaM) has been strongly implicated in the central effects of ethanol.	Cyclic AMP	10-14	calmodulin 2	Mus musculus	61-64
24853690-3	2014	Thus, the cAMP cascade mediator Ca(2+)-dependent calmodulin (CaM) has been strongly implicated in the central effects of ethanol.	Ethanol	121-128	calmodulin 2	Mus musculus	49-59
24853690-3	2014	Thus, the cAMP cascade mediator Ca(2+)-dependent calmodulin (CaM) has been strongly implicated in the central effects of ethanol.	Ethanol	121-128	calmodulin 2	Mus musculus	61-64
24853690-4	2014	OBJECTIVES: In this study, we assessed the role of the CaM inhibitor W7 on ethanol-induced stimulation, ethanol intake, and ethanol-induced activation of PKA.	Ethanol	75-82	calmodulin 2	Mus musculus	55-58
24853690-12	2014	CONCLUSIONS: These results demonstrate that CaM inhibition resulted in a selective reduction of ethanol-stimulating effects and ethanol intake.	Ethanol	96-103	calmodulin 2	Mus musculus	44-47
24853690-12	2014	CONCLUSIONS: These results demonstrate that CaM inhibition resulted in a selective reduction of ethanol-stimulating effects and ethanol intake.	Ethanol	128-135	calmodulin 2	Mus musculus	44-47
24853690-13	2014	The PKA activation induced by ethanol was blocked after the CaM blockade with W7.	Ethanol	30-37	calmodulin 2	Mus musculus	60-63
25168305-0	2014	Calcium dependent interaction of calmodulin with the GlyT1 C-terminus.	Calcium	0-7	calmodulin 2	Mus musculus	33-43
25168305-3	2014	In this work we found that the C-terminal region of the mouse glycine transporter GlyT1b is able to specifically interact with calmodulin in the presence of calcium.	Calcium	157-164	calmodulin 2	Mus musculus	127-137
25168305-5	2014	In tissue-culture-expressed GlyT1 at least two of these mutations altered the sensitivity of GlyT1 surface expression and glycine uptake to calmodulin antagonists.	Glycine	122-129	calmodulin 2	Mus musculus	140-150
25533990-7	2014	The expression level of calmodulin in spiral ganglion neurons was lower in the zonisamide-treated group than that in the saline-treated group (0.336 +- 0.041 vs 0.504 +- 0.020, P < 0.05).	Zonisamide	79-89	calmodulin 2	Mus musculus	24-34
25533990-7	2014	The expression level of calmodulin in spiral ganglion neurons was lower in the zonisamide-treated group than that in the saline-treated group (0.336 +- 0.041 vs 0.504 +- 0.020, P < 0.05).	Sodium Chloride	121-127	calmodulin 2	Mus musculus	24-34
24038040-3	2014	PCLS were incubated with acetaminophen (APAP), 3-acetamidophenol, diclofenac and lipopolysaccharide for 24-48 h. PCLS medium from all species treated with APAP demonstrated similar changes in protein profiles, as previously found in mouse urine after APAP-induced liver injury, including the same key proteins: superoxide dismutase 1, carbonic anhydrase 3 and calmodulin.	Acetaminophen	155-159	calmodulin 2	Mus musculus	360-370
24849454-7	2014	Iqcg interacts with calmodulin in a calcium dependent manner in the testis, suggesting that Iqcg may play a role through calcium signaling.	Calcium	36-43	calmodulin 2	Mus musculus	20-30
24768841-4	2014	Runx2 expression was seen in cultured microglia and BV-2 cells, while sustained exposure to 1mM ATP led to a significant but transient increase in mRNA and corresponding protein expression of Runx2 within 24 h. The increase in Runx2 expression was invariably prevented by several chemicals with antagonistic properties for P2X7 purinergic receptor, calmodulin and calcineurin in BV-2 cells, with a P2X7 receptor agonist more than quadrupling Runx2 expression.	Adenosine Triphosphate	96-99	calmodulin 2	Mus musculus	349-359
24849454-7	2014	Iqcg interacts with calmodulin in a calcium dependent manner in the testis, suggesting that Iqcg may play a role through calcium signaling.	Calcium	121-128	calmodulin 2	Mus musculus	20-30
24828638-3	2014	Patch-clamp recordings and Ca(2+) imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca(2+) influx in inner hair cells via fueling Ca(2+)-ATPases to avoid an increase in cytosolic [Ca(2+)] and subsequent Ca(2+)/calmodulin-dependent inactivation of CaV1.3 channels.	Adenosine Triphosphate	72-75	calmodulin 2	Mus musculus	236-246
24491550-0	2014	Identification of an atypical calcium-dependent calmodulin binding site on the C-terminal domain of GluN2A.	Calcium	30-37	calmodulin 2	Mus musculus	48-58
24491550-5	2014	Using mass spectrometry we identified calmodulin as a calcium-dependent GluN2A binding partner.	Calcium	54-61	calmodulin 2	Mus musculus	38-48
24491550-7	2014	Direct interaction of Ca(2+)/calmodulin with GluN2A was not affected by disruption of classic sequence motifs associated with Ca(2+)/calmodulin target recognition, but was critically dependent upon Trp-1014.	Tryptophan	198-201	calmodulin 2	Mus musculus	29-39