PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31088910-3	2019	Here, we conducted in vitro assays in the Drosophila S2 cell line with the Toll/interleukin-1 receptor (TIR) homology domains of each Toll family member to determine whether they can activate a known target of Toll-1, the promoter of the antifungal peptide gene drosomycin.	drosomycin	262-272	Toll	Drosophila melanogaster	210-216
31088910-5	2019	We found that the Toll-1 and Toll-7 ectodomains bind Spz-1, -2, and -5, and also vesicular stomatitis virus (VSV) virions, and that Spz-1, -2, -5, and VSV all activated the promoters of drosomycin and several other AMP genes in S2 cells expressing full-length Toll-1 or Toll-7.	drosomycin	186-196	Toll	Drosophila melanogaster	18-24
31088910-5	2019	We found that the Toll-1 and Toll-7 ectodomains bind Spz-1, -2, and -5, and also vesicular stomatitis virus (VSV) virions, and that Spz-1, -2, -5, and VSV all activated the promoters of drosomycin and several other AMP genes in S2 cells expressing full-length Toll-1 or Toll-7.	Adenosine Monophosphate	215-218	Toll	Drosophila melanogaster	18-24
30735676-2	2019	Expression of AMP genes is mediated by the Toll and immune deficiency (IMD) pathways via NF-kappaB transcription factors Dorsal, DIF and Relish.	Adenosine Monophosphate	14-17	Toll	Drosophila melanogaster	43-47
30633769-4	2019	lincRNA-IBIN is induced by both Gram-positive and Gram-negative bacteria in Drosophila adults and parasitoid wasp Leptopilina boulardi in Drosophila larvae, as well as by the activation of the Toll or the Imd pathway in unchallenged flies.	lincrna-ibin	0-12	Toll	Drosophila melanogaster	193-197
30633769-6	2019	In the fat body, overexpression of lincRNA-IBIN affected the expression of Toll pathway -mediated genes.	lincrna-ibin	35-47	Toll	Drosophila melanogaster	75-79
27974298-0	2017	miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.	mir-958	0-7	Toll	Drosophila melanogaster	17-21
29268741-11	2017	The dimorphism in pathway activation can be specifically attributed to Persephone-mediated immune stimulation, by which the Toll pathway is triggered in response to pathogen-derived virulence factors.	persephone	71-81	Toll	Drosophila melanogaster	124-128
28273919-8	2017	The ARF1-Asrij axis suppresses the Toll pathway anti-microbial peptides (AMPs) by regulating ubiquitination of the inhibitor Cactus.	Adenylyl sulfate	73-77	Toll	Drosophila melanogaster	35-39
29091025-0	2017	Reactive oxygen species-dependent Toll/NF-kappaB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism.	Reactive Oxygen Species	0-23	Toll	Drosophila melanogaster	34-38
27974298-0	2017	miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.	mir-958	0-7	Toll	Drosophila melanogaster	82-86
27974298-4	2017	We further demonstrate in vitro and in vivo that miR-958 targets the Toll and Dif genes, key components of the Toll signaling pathway, to negatively regulate Drosomycin expression.	mir-958	49-56	Toll	Drosophila melanogaster	69-73
27974298-4	2017	We further demonstrate in vitro and in vivo that miR-958 targets the Toll and Dif genes, key components of the Toll signaling pathway, to negatively regulate Drosomycin expression.	mir-958	49-56	Toll	Drosophila melanogaster	111-115
27974298-6	2017	These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity.	mir-958	76-83	Toll	Drosophila melanogaster	161-165
27429771-13	2016	Results showed that Hcu_Toll-2-2 had stronger antimicrobial peptide (AMP) activity than Hcu_Toll-I.	Adenosine Monophosphate	69-72	Toll	Drosophila melanogaster	24-28
27429771-14	2016	Therefore, enhanced AMP-induced activity resulted from tandem TIRs in Toll-2s of molluscs during evolution history.	Adenosine Monophosphate	20-23	Toll	Drosophila melanogaster	70-74
25901322-6	2015	In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges.	Galactose	40-49	Toll	Drosophila melanogaster	104-108
26916032-0	2016	Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.	Alcohols	0-7	Toll	Drosophila melanogaster	53-57
26916032-2	2016	Here, we show that the Toll innate immune signaling pathway modulates the level of alcohol resistance in Drosophila.	Alcohols	83-90	Toll	Drosophila melanogaster	23-27
26916032-5	2016	The Toll pathway is a major regulator of innate immunity in Drosophila, and mammalian Toll-like receptor signaling has been implicated in alcohol responses.	Alcohols	138-145	Toll	Drosophila melanogaster	4-8
26916032-5	2016	The Toll pathway is a major regulator of innate immunity in Drosophila, and mammalian Toll-like receptor signaling has been implicated in alcohol responses.	Alcohols	138-145	Toll	Drosophila melanogaster	86-90
26916032-6	2016	Here, we use Drosophila-specific genetic tools to test eight genes in the Toll signaling pathway for effects on the level of response to ethanol.	Ethanol	137-144	Toll	Drosophila melanogaster	74-78
26916032-9	2016	The interaction between the Toll signaling pathway and ethanol is rooted in the natural history of Drosophila melanogaster.	Ethanol	55-62	Toll	Drosophila melanogaster	28-32
26453810-12	2016	Clip-SPs are implicated in three main biological processes: the control of the dorso-ventral patterning during embryonic development; the activation of the Toll-mediated response to microbial infections and the prophenoloxydase cascade, which triggers melanization.	clip-sps	0-8	Toll	Drosophila melanogaster	156-160
25901322-6	2015	In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges.	Polysaccharides	61-68	Toll	Drosophila melanogaster	104-108
25901322-8	2015	Interestingly, Toll activation in immune-challenged wild type (WT) flies reduced the expression of galactose-containing glycans.	Galactose	99-108	Toll	Drosophila melanogaster	15-19
25901322-8	2015	Interestingly, Toll activation in immune-challenged wild type (WT) flies reduced the expression of galactose-containing glycans.	Polysaccharides	120-127	Toll	Drosophila melanogaster	15-19
24842780-2	2014	Expression of AMPs is induced in response to infection by the Toll and Imd pathway.	Adenylyl sulfate	14-18	Toll	Drosophila melanogaster	62-66
23596533-1	2013	The Drosophila humoral innate immune response fights infection by producing antimicrobial peptides (AMPs) through the microbe-specific activation of the Toll or the Imd signaling pathway.	Adenylyl sulfate	100-104	Toll	Drosophila melanogaster	153-157
24842780-9	2014	The FKH-dependent induction of Dpt and Mtk can be triggered in dFOXO null mutants and in immune-compromised Toll and IMD pathway mutants indicating that FKH acts in parallel to these regulators.	dpt	31-34	Toll	Drosophila melanogaster	108-112
24837378-6	2014	Since Spn43Ac acts to inhibit Toll-mediated activation of defense responses, we explored the feasibility of a new strategy to engineer entomopathogenic fungi with increased virulence by expression of Spn43Ac in the fungus.	spn43ac	6-13	Toll	Drosophila melanogaster	30-34
24282309-4	2013	The cystine knot of Spz binds the concave face of the Toll leucine-rich repeat solenoid in an area delineated by N-linked glycans and induces a conformational change.	Cystine	4-11	Toll	Drosophila melanogaster	54-58
24282309-4	2013	The cystine knot of Spz binds the concave face of the Toll leucine-rich repeat solenoid in an area delineated by N-linked glycans and induces a conformational change.	n-linked glycans	113-129	Toll	Drosophila melanogaster	54-58
24631579-10	2014	This research is the first report of an atypical Toll-like receptor HcToll-2 involved in antibacterial immunity through induction of AMP expression.	Adenosine Monophosphate	133-136	Toll	Drosophila melanogaster	49-53
23803447-9	2013	But the Toll pathway was not activated like Imd pathway and the expression levels of AMPs from this pathway was reduced.	Adenylyl sulfate	85-89	Toll	Drosophila melanogaster	8-12
23485525-4	2013	MgTLR-b, -i and -k were the only ones containing a multiple cysteine cluster (mccTLR), a domain composition also found in Drosophila Toll-1 and 18-wheeler.	Cysteine	60-68	Toll	Drosophila melanogaster	133-139
23261474-3	2013	This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin.	drosomycin	217-227	Toll	Drosophila melanogaster	190-194
22516181-2	2012	Drosophila Toll pathway is activated after Spatzle (Spz) is cleaved by Spatzle processing enzyme (SPE) to release the active C-terminal C106 domain (DmSpz-C106), which then binds to the Toll receptor to initiate the signaling pathway and regulate expression of AMP genes such as drosomycin.	Adenosine Monophosphate	261-264	Toll	Drosophila melanogaster	11-15
22516181-2	2012	Drosophila Toll pathway is activated after Spatzle (Spz) is cleaved by Spatzle processing enzyme (SPE) to release the active C-terminal C106 domain (DmSpz-C106), which then binds to the Toll receptor to initiate the signaling pathway and regulate expression of AMP genes such as drosomycin.	Adenosine Monophosphate	261-264	Toll	Drosophila melanogaster	186-190
22516181-7	2012	In vivo assays showed that activation of AMP genes, including cecropin, attacin, moricin and lebocin, in M. sexta larvae by purified recombinant MsSpz-C108 could be blocked by pre-injection of antibody to MsToll, further confirming a Toll-Spz pathway in M. sexta, a lepidopteran insect.	Adenosine Monophosphate	41-44	Toll	Drosophila melanogaster	207-211
22516181-7	2012	In vivo assays showed that activation of AMP genes, including cecropin, attacin, moricin and lebocin, in M. sexta larvae by purified recombinant MsSpz-C108 could be blocked by pre-injection of antibody to MsToll, further confirming a Toll-Spz pathway in M. sexta, a lepidopteran insect.	lebocin	93-100	Toll	Drosophila melanogaster	207-211
22210547-2	2012	In Drosophila, septic injury by microbial pathogens rapidly induces the production of the AMPs in fat body via well elucidated pathways such as Toll and IMD.	Adenylyl sulfate	90-94	Toll	Drosophila melanogaster	144-148
22464168-0	2012	Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.	Phosphatidylinositols	0-16	Toll	Drosophila melanogaster	32-36
22005212-2	2011	Induction of insect AMP genes is regulated by the Toll and IMD (immune deficiency) pathways via NF-kappaB and GATA factors.	Adenosine Monophosphate	20-23	Toll	Drosophila melanogaster	50-54
22355724-3	2012	We demonstrated that growth-blocking peptide (GBP) is a potent cytokine that regulates stressor-induced AMP expression in insects.GBP overexpression in Drosophila elevated expression of AMPs.GBP-induced AMP expression did not require Toll and immune deficiency (Imd) pathway-related genes, but imd and basket were essential,indicating that GBP signaling in Drosophila did not use the orthodox Toll or Imd pathway but used the JNK pathway after association with the adaptor protein Imd.	Adenosine Monophosphate	186-189	Toll	Drosophila melanogaster	234-238
22355724-3	2012	We demonstrated that growth-blocking peptide (GBP) is a potent cytokine that regulates stressor-induced AMP expression in insects.GBP overexpression in Drosophila elevated expression of AMPs.GBP-induced AMP expression did not require Toll and immune deficiency (Imd) pathway-related genes, but imd and basket were essential,indicating that GBP signaling in Drosophila did not use the orthodox Toll or Imd pathway but used the JNK pathway after association with the adaptor protein Imd.	Adenosine Monophosphate	186-189	Toll	Drosophila melanogaster	393-397
20702416-2	2010	The Toll signaling pathway responds mainly to the lysine-type peptidoglycan of Gram-positive bacteria and fungal beta-1,3-glucan, whereas the Imd pathway responds to the meso-diaminopimelic acid (DAP)-type peptidoglycan of Gram-negative bacteria and certain Gram-positive bacilli.	Lysine	50-56	Toll	Drosophila melanogaster	4-8
21424695-1	2011	The Toll pathway of Drosophila melanogaster, when activated by the Beauveria bassiana fungus, directs the expression of the drosomycin and metchnikowin antimicrobial peptide genes by inducing the translocation into the nucleus of the DIF transcription factor.	drosomycin	124-134	Toll	Drosophila melanogaster	4-8
20702416-2	2010	The Toll signaling pathway responds mainly to the lysine-type peptidoglycan of Gram-positive bacteria and fungal beta-1,3-glucan, whereas the Imd pathway responds to the meso-diaminopimelic acid (DAP)-type peptidoglycan of Gram-negative bacteria and certain Gram-positive bacilli.	beta-1,3-glucan	113-128	Toll	Drosophila melanogaster	4-8
20702416-2	2010	The Toll signaling pathway responds mainly to the lysine-type peptidoglycan of Gram-positive bacteria and fungal beta-1,3-glucan, whereas the Imd pathway responds to the meso-diaminopimelic acid (DAP)-type peptidoglycan of Gram-negative bacteria and certain Gram-positive bacilli.	Diaminopimelic Acid	196-199	Toll	Drosophila melanogaster	4-8
20090753-3	2010	In Drosophila, the induction of AMPs in response to infection is regulated through the activation of the evolutionarily conserved Toll and immune deficiency (IMD) pathways.	Adenylyl sulfate	32-36	Toll	Drosophila melanogaster	130-134
20457811-5	2010	Dfr/Vvl overexpression activates transcription of several AMP genes in uninfected flies in a Toll pathway- and Imd pathway-independent manner.	Adenosine Monophosphate	58-61	Toll	Drosophila melanogaster	93-97
20504957-6	2010	Conversely, ectopic expression of Toll in M12 inhibited synapse formation by MN12s.	mn12s	77-82	Toll	Drosophila melanogaster	34-38
20504957-7	2010	These results suggest that Toll functions in M13 to prevent synapse formation by MN12s.	mn12s	81-86	Toll	Drosophila melanogaster	27-31
20090753-7	2010	Expression of AMP genes in response to FOXO activity can also be triggered in animals unable to respond to immune challenges due to defects in both the Toll and IMD pathways.	Adenosine Monophosphate	14-17	Toll	Drosophila melanogaster	152-156
19934223-5	2009	Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes.	Adenosine Monophosphate	18-21	Toll	Drosophila melanogaster	41-45
19934223-5	2009	Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes.	Adenosine Monophosphate	18-21	Toll	Drosophila melanogaster	89-93
18977438-2	2009	In Drosophila, two signaling pathways, govern the challenge-dependent expression of AMPs; the Toll and IMD pathways.	Adenylyl sulfate	84-88	Toll	Drosophila melanogaster	94-98
19754735-2	2009	The systemic expression of drosomycin is regulated by the Toll pathway present in fat body, whereas inducible local expression in the respiratory tract is controlled by the Immune Deficiency (IMD) pathway.	drosomycin	27-37	Toll	Drosophila melanogaster	58-62
16169493-2	2005	In Drosophila, the Toll pathway (activated by fungi and gram-positive bacteria) and the Imd pathway (activated by gram-negative bacteria) lead to the synthesis of AMPs.	Adenylyl sulfate	163-167	Toll	Drosophila melanogaster	19-23
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Lysine	42-48	Toll	Drosophila melanogaster	155-159
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Polysaccharides	61-67	Toll	Drosophila melanogaster	155-159
18519585-1	2008	Drosophila innate immunity is controlled primarily by the activation of IMD (immune deficiency) or Toll signaling leading to the production of antimicrobial peptides (AMPs).	Adenylyl sulfate	167-171	Toll	Drosophila melanogaster	99-103
18304640-10	2008	Our hypothesis is that the role of PGRP-SD is the recognition of DAP-type PGNs responsible for the activation of the Toll pathway by Gram-negative bacteria.	pgns	74-78	Toll	Drosophila melanogaster	117-121
15791270-5	2005	We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity.	muropeptide	102-113	Toll	Drosophila melanogaster	84-88
15791270-5	2005	We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity.	N-acetylmuramic acid	158-179	Toll	Drosophila melanogaster	84-88
15791270-5	2005	We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity.	muropeptides	196-208	Toll	Drosophila melanogaster	84-88
15197269-4	2004	We also show that constitutively active mutants of Toll form multimers that contain intermolecular disulfide linkages.	Disulfides	99-108	Toll	Drosophila melanogaster	51-55
15197269-6	2004	Furthermore, systematic mutational analysis revealed that a conserved cysteine-containing motif, different from the cysteines used for the intermolecular disulfide linkages, serves as a self-inhibitory module of Toll.	Cysteine	70-78	Toll	Drosophila melanogaster	212-216
15197269-6	2004	Furthermore, systematic mutational analysis revealed that a conserved cysteine-containing motif, different from the cysteines used for the intermolecular disulfide linkages, serves as a self-inhibitory module of Toll.	Cysteine	116-125	Toll	Drosophila melanogaster	212-216
15197269-6	2004	Furthermore, systematic mutational analysis revealed that a conserved cysteine-containing motif, different from the cysteines used for the intermolecular disulfide linkages, serves as a self-inhibitory module of Toll.	Disulfides	154-163	Toll	Drosophila melanogaster	212-216
12098703-5	2002	We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection.	Ethyl Methanesulfonate	13-35	Toll	Drosophila melanogaster	153-157
12532402-8	2003	We also observed that the inhibition of the calcium dependent protein phosphatase calcineurin prevents the effect of glutamate on the fluorescence for Dorsal and Cactus, suggesting its participation in a signal transduction cascade that may activate Dorsal in the muscle independently of Toll.	Calcium	44-51	Toll	Drosophila melanogaster	288-292
12532402-8	2003	We also observed that the inhibition of the calcium dependent protein phosphatase calcineurin prevents the effect of glutamate on the fluorescence for Dorsal and Cactus, suggesting its participation in a signal transduction cascade that may activate Dorsal in the muscle independently of Toll.	Glutamic Acid	117-126	Toll	Drosophila melanogaster	288-292
2242162-3	1990	We further present evidence that sim is required for midline expression of a group of genes including slit, Toll, rhomboid, engrailed, and a gene at 91F; that the sim mutant CNS defect may be largely due to loss of midline slit expression; and that the snail gene is required to repress sim and other midline genes in the presumptive mesoderm.	sim	33-36	Toll	Drosophila melanogaster	108-112
12032070-2	2002	However, little is known about the control of most of the fly immune-responsive genes, except for the antimicrobial peptide (AMP)-encoding genes, which are regulated by the Toll and Imd pathways.	Adenosine Monophosphate	125-128	Toll	Drosophila melanogaster	173-177
12032070-3	2002	Here, we used oligonucleotide microarrays to monitor the effect of mutations affecting the Toll and Imd pathways on the expression programme induced by septic injury in Drosophila adults.	Oligonucleotides	14-29	Toll	Drosophila melanogaster	91-95
12032070-4	2002	We found that the Toll and Imd cascades control the majority of the genes regulated by microbial infection in addition to AMP genes and are involved in nearly all known Drosophila innate immune reactions.	Adenosine Monophosphate	122-125	Toll	Drosophila melanogaster	18-22
8404539-1	1993	The establishment of the dorsal-ventral pattern in Drosophila embryos depends on a signal transduction process: a putative extracellular ligand released into the perivitelline space surrounding the embryo binds to the Toll receptor.	perivitelline	162-175	Toll	Drosophila melanogaster	218-231
10625561-6	2000	We further show that this calcium gradient is inhibited in pipe, Toll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that the stage 5 calcium gradient is formed by a suppression of ventral calcium concentrations.	Calcium	26-33	Toll	Drosophila melanogaster	65-69
10625561-6	2000	We further show that this calcium gradient is inhibited in pipe, Toll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that the stage 5 calcium gradient is formed by a suppression of ventral calcium concentrations.	Calcium	178-185	Toll	Drosophila melanogaster	65-69
10625561-6	2000	We further show that this calcium gradient is inhibited in pipe, Toll, and dorsal mutants, but is unaltered in decapentaplegic (dpp) or punt mutants, suggesting that the stage 5 calcium gradient is formed by a suppression of ventral calcium concentrations.	Calcium	178-185	Toll	Drosophila melanogaster	65-69
10489372-2	1999	Here, a loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products.	drosomycin	170-180	Toll	Drosophila melanogaster	231-235
2124970-4	1990	We propose that these sequences in Toll form disulphide linked extracellular domains that are important for the binding of ligands in the perivitelline space of the embryo.	disulphide	45-55	Toll	Drosophila melanogaster	35-39
35440411-3	2022	The Toll and Imd signaling pathways operate in organs such as fat body and gut that control host nutrient metabolism, and infections or genetic activation of Toll and Imd signaling also induce wide-ranging changes in host lipid, carbohydrate and protein metabolism.	Carbohydrates	229-241	Toll	Drosophila melanogaster	4-8
34576280-3	2021	In this study, we firstly discover that the overexpression of lncRNA-CR11538 can inhibit the expressions of antimicrobial peptides Drosomycin (Drs) and Metchnikowin (Mtk) in vivo, thereby suppressing the Toll signaling pathway.	(9S,12S)-9-(1-methylethyl)-7,10-dioxo-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-12-carboxylic acid	143-146	Toll	Drosophila melanogaster	204-208
34432851-6	2021	BaraA is strongly immune-induced in the fat body downstream of the Toll pathway, but also exhibits expression in other tissues.	baraa	0-5	Toll	Drosophila melanogaster	67-71
35440411-3	2022	The Toll and Imd signaling pathways operate in organs such as fat body and gut that control host nutrient metabolism, and infections or genetic activation of Toll and Imd signaling also induce wide-ranging changes in host lipid, carbohydrate and protein metabolism.	Carbohydrates	229-241	Toll	Drosophila melanogaster	158-162
35379744-5	2022	Mechanically, lncRNA-CR33942 interacts with the NF-kappaB transcription factors Dorsal-related immunity factor/Dorsal to promote the transcriptions of antimicrobial peptides drosomycin and metchnikowin, thus enhancing Drosophila Toll immune responses.	drosomycin	174-184	Toll	Drosophila melanogaster	229-233
35379744-5	2022	Mechanically, lncRNA-CR33942 interacts with the NF-kappaB transcription factors Dorsal-related immunity factor/Dorsal to promote the transcriptions of antimicrobial peptides drosomycin and metchnikowin, thus enhancing Drosophila Toll immune responses.	metchnikowin	189-201	Toll	Drosophila melanogaster	229-233
32174999-8	2020	Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production.	ros	76-79	Toll	Drosophila melanogaster	9-13
33555648-8	2021	Our results also reveal the nuclear accumulation of transcription factors Dorsal and Dif and expression of Toll associated Anti-Microbial Peptides (AMP) in Dx over-expression background.	Adenosine Monophosphate	148-151	Toll	Drosophila melanogaster	107-111
33227003-10	2020	Our results establish that Toll signaling induces a shift in anabolic lipid metabolism to favor phospholipid synthesis and ER expansion that may serve the immediate demand for AMP synthesis and secretion but with the long-term consequence of insufficient nutrient storage.	Adenosine Monophosphate	176-179	Toll	Drosophila melanogaster	27-31
32631949-4	2020	AMPs are effectors of pathogen and stress defense mechanisms mediated by the evolutionarily conserved Toll and Immune-deficiency (Imd) innate immune response pathways that activate Nuclear Factor kappa B (NF-kB) transcription factors.	Adenylyl sulfate	0-4	Toll	Drosophila melanogaster	102-106
32188787-6	2020	Next, we show that the iron transporter Tsf1 is induced by infections downstream of the Toll and Imd pathways and is necessary for iron relocation from the hemolymph to the fat body.	Iron	23-27	Toll	Drosophila melanogaster	88-92
35225961-1	2022	The Toll signaling pathway is the main source of embryonic DV polarity in the fly Drosophila melanogaster.	Dienestrol	59-61	Toll	Drosophila melanogaster	4-8
33932332-4	2021	Toll receptors target Src activity to specific sites at the membrane, and Src recruits PI3K to the Toll-2 complex through tyrosine phosphorylation of the Toll-2 cytoplasmic domain.	Tyrosine	122-130	Toll	Drosophila melanogaster	0-4
33227003-4	2020	We find that genetic or physiological activation of fat body Toll signaling leads to a tissue-autonomous reduction in triglyceride storage that is paralleled by decreased transcript levels of the DGAT homolog midway, which carries out the final step of triglyceride synthesis.	Triglycerides	118-130	Toll	Drosophila melanogaster	61-65
33227003-4	2020	We find that genetic or physiological activation of fat body Toll signaling leads to a tissue-autonomous reduction in triglyceride storage that is paralleled by decreased transcript levels of the DGAT homolog midway, which carries out the final step of triglyceride synthesis.	Triglycerides	253-265	Toll	Drosophila melanogaster	61-65
33227003-6	2020	Mass spectrometry analysis revealed elevated levels of major phosphatidylcholine and phosphatidylethanolamine species in fat bodies with active Toll signaling.	Phosphatidylcholines	61-80	Toll	Drosophila melanogaster	144-148
33227003-7	2020	The ER stress mediator Xbp1 contributed to the Toll-dependent induction of Kennedy pathway enzymes, which was blunted by deleting AMP genes, thereby reducing secretory demand elicited by Toll activation.	Adenosine Monophosphate	130-133	Toll	Drosophila melanogaster	47-51
33227003-7	2020	The ER stress mediator Xbp1 contributed to the Toll-dependent induction of Kennedy pathway enzymes, which was blunted by deleting AMP genes, thereby reducing secretory demand elicited by Toll activation.	Adenosine Monophosphate	130-133	Toll	Drosophila melanogaster	187-191
33227003-10	2020	Our results establish that Toll signaling induces a shift in anabolic lipid metabolism to favor phospholipid synthesis and ER expansion that may serve the immediate demand for AMP synthesis and secretion but with the long-term consequence of insufficient nutrient storage.	Phospholipids	96-108	Toll	Drosophila melanogaster	27-31