PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 6849115-4 1983 Receptor-positive tumors treated with estradiol produced elevated concentrations of progesterone receptor. Estradiol 38-47 progesterone receptor Mus musculus 84-105 33911053-6 2021 In contrast, Pgrmc1 hetero KO mice that have been ovariectomized (OVX), including letrozole-treated OVX mice (OVX-letrozole), exhibited high estrogen levels and PR expression. Letrozole 82-91 progesterone receptor Mus musculus 161-163 33792845-11 2021 Notably, the levels of serum estrogen (E2) and progesterone (P4) and expression levels of uterus estrogen receptor alpha (ERalpha) and progesterone receptor (PR) during early pregnancy were significantly upregulated following BHT exposure. Butylated Hydroxytoluene 226-229 progesterone receptor Mus musculus 135-156 33792845-11 2021 Notably, the levels of serum estrogen (E2) and progesterone (P4) and expression levels of uterus estrogen receptor alpha (ERalpha) and progesterone receptor (PR) during early pregnancy were significantly upregulated following BHT exposure. Butylated Hydroxytoluene 226-229 progesterone receptor Mus musculus 158-160 890694-4 1977 Furthermore, the estrogen and progesterone receptor contents of the residual tumor masses after cyclophosphamide treatment were about the same as those of untreated tumors. Cyclophosphamide 96-112 progesterone receptor Mus musculus 30-51 34057651-9 2021 RESULTS: In T-47D-xenografted tumors, estrogen and progesterone treatment reduced PGR and KI67 mRNA expression, and reduced PR and Ki67 protein positivity, compared to estrogen treatment alone. Progesterone 51-63 progesterone receptor Mus musculus 82-85 33358972-12 2021 Last, paraben selectively alters the levels of progesterone receptor. Parabens 6-13 progesterone receptor Mus musculus 47-68 33316053-11 2021 These data suggest that phthalate exposure inhibits ovulation by altering PG levels, P4/PGR action, and ECM remodeling. phthalic acid 24-33 progesterone receptor Mus musculus 88-91 33099617-2 2020 Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after ovulation and regulates uterine gene transcription for successful embryo implantation. Progesterone 57-69 progesterone receptor Mus musculus 8-11 32915211-1 2020 The physiological functions of progesterone (P4) in female reproductive organs including the mammary glands are mediated via the progesterone receptor (PR), but not all P4 functions can be explained by PR-mediated signaling. Progesterone 31-43 progesterone receptor Mus musculus 129-150 32915211-1 2020 The physiological functions of progesterone (P4) in female reproductive organs including the mammary glands are mediated via the progesterone receptor (PR), but not all P4 functions can be explained by PR-mediated signaling. Progesterone 31-43 progesterone receptor Mus musculus 152-154 32946892-5 2020 Although mRNA level of PRLR and GR was similar between treatments, mRNA expression of ESR1, total PR, PR-B and Stat5a was increased in organoids exposed to 1x10-9M BPA and 1x10-12M BP3. bisphenol A 164-167 progesterone receptor Mus musculus 102-106 32946892-6 2020 Total PR expression was also increased with 1x10-6M BPA. bisphenol A 52-55 progesterone receptor Mus musculus 6-8 32558878-2 2020 Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcriptional coregulators, progesterone inhibits E2-induced cell proliferation and induces the differentiation of stromal cells in a process called decidualization to promote endometrial receptivity. Estradiol 134-136 progesterone receptor Mus musculus 12-33 33007382-7 2020 Moreover, incubation of splenocytes from TCE-treated mice with HNE-modified proteins resulted in enhanced splenocyte proliferation and cytokine release evidenced by increased expression of cyclin D3, Cyclin-dependent kinase 6 (CDK6) and phospho-pRb as well as increased release of IL-6, TNF-alpha and INF-gamma. Trichloroethylene 41-44 progesterone receptor Mus musculus 245-248 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 46-58 progesterone receptor Mus musculus 14-35 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 46-58 progesterone receptor Mus musculus 200-221 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 46-58 progesterone receptor Mus musculus 223-226 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 60-62 progesterone receptor Mus musculus 14-35 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 60-62 progesterone receptor Mus musculus 200-221 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Mifepristone 60-62 progesterone receptor Mus musculus 223-226 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Steroids 121-128 progesterone receptor Mus musculus 14-35 32558878-2 2020 Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcriptional coregulators, progesterone inhibits E2-induced cell proliferation and induces the differentiation of stromal cells in a process called decidualization to promote endometrial receptivity. Estradiol 134-136 progesterone receptor Mus musculus 35-38 33000549-5 2020 Proteins from SKF-treated hypothalami were pulled-down with glutathione S-transferase-tagged mouse PR-A or PR-B and the interactomes were analysed by mass spectrometry. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 14-17 progesterone receptor Mus musculus 107-111 32072231-8 2020 After treated with 3-methyladenine, the expression of decidual markers HOXA10 and progesterone receptor were significantly reduced. 3-methyladenine 19-34 progesterone receptor Mus musculus 82-103 32932770-2 2020 Flow cytometry and mammosphere assays revealed that in murine breast, overexpression of PRB leads to an increase in luminal and basal progenitor/stem cells. Phenobarbital 116-123 progesterone receptor Mus musculus 88-91 31809260-4 2020 With the aforementioned as historical backdrop, this review focusses on a selection of key advances in our understanding of the molecular mechanisms by which progesterone, through its nuclear receptor (the progesterone receptor), drives the development of endometrial receptivity, a transient uterine state that allows for embryo implantation and the establishment of pregnancy. Progesterone 158-170 progesterone receptor Mus musculus 206-227 32408168-4 2020 Progesterone receptor inhibition by RU486 treatment at GD18.5 blocked the delay of parturition. Mifepristone 36-41 progesterone receptor Mus musculus 0-21 32818842-7 2020 Enzalutamide treatment increased Progesterone Receptor (PR) expression within both stromal and tumor cell compartments. enzalutamide 0-12 progesterone receptor Mus musculus 33-54 32818842-7 2020 Enzalutamide treatment increased Progesterone Receptor (PR) expression within both stromal and tumor cell compartments. enzalutamide 0-12 progesterone receptor Mus musculus 56-58 32818842-10 2020 Induction of PR, a negative regulator of endometrial proliferation, suggests that adding progestin therapy to enzalutamide administration may further decrease tumor burden and result in a prolonged response. enzalutamide 110-122 progesterone receptor Mus musculus 13-15 32295179-3 2020 It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone 17-29 progesterone receptor Mus musculus 152-173 32295179-3 2020 It is known that progesterone promotes the proliferation and differentiation of OPC in early postnatal life through the activation of the intracellular progesterone receptor (PR). Progesterone 17-29 progesterone receptor Mus musculus 175-177 32295179-5 2020 However, the role of progesterone in embryonic OPC differentiation as well as the specific PR isoform involved in progesterone actions in these cells is unknown. Progesterone 114-126 progesterone receptor Mus musculus 91-93 32295179-7 2020 We found that progesterone increases the proliferation, differentiation, and myelination potential of embryonic OPC through its PR by upregulating the expression of oligodendroglial genes such as neuron/glia antigen 2 (NG2), sex determining region Y-box9 (SOX9), myelin basic protein (MBP), 2",3"-cyclic-nucleotide 3"-phosphodiesterase (CNP1), and NK6 homeobox 1 (NKX 6.1). Progesterone 14-26 progesterone receptor Mus musculus 128-130 32295179-9 2020 The results suggest that progesterone contributes to the process of oligodendrogenesis during prenatal life through specific activation of PR-B. Progesterone 25-37 progesterone receptor Mus musculus 139-143 31638694-9 2020 Furthermore, excess P4 treatment before implantation decreased decidual P4 receptor (PGR) expression and induced decidualization defect apart from LIF downregulation. propiverine 20-22 progesterone receptor Mus musculus 85-88 31771930-8 2020 The level of progesterone receptor was down-regulated by DEHP and MEHP in mouse placenta and in JEG-3 cells, respectively. di-n-hexyl phthalate 57-61 progesterone receptor Mus musculus 13-34 31593881-6 2020 BPA increased the ovarian/uterine index in F1 females at both PND 21 and 56, increased the mRNA relative transcript levels of ovarian ERalpha, PgR and DNA methyltransferase (DNMT) in F1 females at PND 21, while decreased at PND 56 (P < 0.01 or P < 0.05). bisphenol A 0-3 progesterone receptor Mus musculus 143-146 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Progesterone 10-22 progesterone receptor Mus musculus 117-138 31509448-4 2019 In this study, we show that Prkg2 has a gradually increased expression pattern during peri-implantation and artificial decidualization, and the expression of Prkg2 is induced by estrogen and progesterone in the ovariectomized mouse uteri and primary cultured uterine stromal cells, the process of which is blocked by treating with estrogen receptor (ER) antagonist (ICI 182,780) and progesterone receptor (PR) antagonist (RU486). Mifepristone 422-427 progesterone receptor Mus musculus 383-404 31509448-4 2019 In this study, we show that Prkg2 has a gradually increased expression pattern during peri-implantation and artificial decidualization, and the expression of Prkg2 is induced by estrogen and progesterone in the ovariectomized mouse uteri and primary cultured uterine stromal cells, the process of which is blocked by treating with estrogen receptor (ER) antagonist (ICI 182,780) and progesterone receptor (PR) antagonist (RU486). Mifepristone 422-427 progesterone receptor Mus musculus 406-408 31732107-0 2019 Medroxyprogesterone Acetate Prevention of Cervical Cancer through Progesterone Receptor in a Human Papillomavirus Transgenic Mouse Model. Medroxyprogesterone Acetate 0-27 progesterone receptor Mus musculus 66-87 31732107-9 2019 Confirming the role of the progesterone receptor, the preventive effect of MPA was absent in human papillomavirus transgenic mice in which the expression of progesterone receptor was genetically ablated. Medroxyprogesterone Acetate 75-78 progesterone receptor Mus musculus 27-48 31732107-9 2019 Confirming the role of the progesterone receptor, the preventive effect of MPA was absent in human papillomavirus transgenic mice in which the expression of progesterone receptor was genetically ablated. Medroxyprogesterone Acetate 75-78 progesterone receptor Mus musculus 157-178 31732107-10 2019 These results suggest that MPA is efficient in treating progesterone receptor-positive CIN lesions. Medroxyprogesterone Acetate 27-30 progesterone receptor Mus musculus 56-77 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Progesterone 10-22 progesterone receptor Mus musculus 230-232 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Glucose 33-40 progesterone receptor Mus musculus 117-138 31647947-7 2019 In vitro, progesterone increased glucose uptake in primary cultured cortical neurons, this effect was blocked by the progesterone receptor membrane component 1 (PGRMC1)-specific blocker AG205 but not by the progesterone receptor (PR)-specific blocker RU486. Mifepristone 251-256 progesterone receptor Mus musculus 117-138 30738183-7 2019 Furthermore, chronic CS exposure decreased the pGR-S211/pGR-S226 ratio, increased the active nuclear GR, and impaired cytosolic GR binding capacity and GR transcriptional activity, which might be responsible for the activation of the inflammasome-induced inflammatory cascade. Cesium 21-23 progesterone receptor Mus musculus 47-50 31091357-7 2019 Progesterone receptor antagonist (mifepristone) or knock-down DAF with specific siRNA, above the protective effects of progesterone, were significantly weakened. Mifepristone 34-46 progesterone receptor Mus musculus 0-21 31091357-7 2019 Progesterone receptor antagonist (mifepristone) or knock-down DAF with specific siRNA, above the protective effects of progesterone, were significantly weakened. Progesterone 119-131 progesterone receptor Mus musculus 0-21 31660453-9 2019 These results show that the chronic lows-dose exposing of NP or DEHP modify the localization and colocalization of ESRs and PGR, and of the proliferation patterns of the endometrial tissues. nonylphenol 58-60 progesterone receptor Mus musculus 124-127 31660453-9 2019 These results show that the chronic lows-dose exposing of NP or DEHP modify the localization and colocalization of ESRs and PGR, and of the proliferation patterns of the endometrial tissues. Diethylhexyl Phthalate 64-68 progesterone receptor Mus musculus 124-127 31355130-7 2019 Melatonin significantly suppressed amphiregulin transcripts in MEL and MEPT mammary glands, suggesting that amphiregulin together with the higher PRA:PRB balance and other factors may contribute to reducing cancer development in MEPT mice. Melatonin 0-9 progesterone receptor Mus musculus 150-153 31735496-6 2019 This cyclic increase in connectivity is found in adult females, but not males, and regulated by estrogen signaling in PR+ VMH neurons. Estrogens 96-104 progesterone receptor Mus musculus 118-120 31701034-6 2019 Through single-cell RNA sequencing (scRNAseq) analysis, E2 was found to induce Pgr expression in both Esr1 + and Esr1 - luminal epithelial cells and Ccl2 expression in Esr1 + fibroblasts. Estradiol 56-58 progesterone receptor Mus musculus 79-82 31701034-6 2019 Through single-cell RNA sequencing (scRNAseq) analysis, E2 was found to induce Pgr expression in both Esr1 + and Esr1 - luminal epithelial cells and Ccl2 expression in Esr1 + fibroblasts. Phenobarbital 120-127 progesterone receptor Mus musculus 79-82 30738183-7 2019 Furthermore, chronic CS exposure decreased the pGR-S211/pGR-S226 ratio, increased the active nuclear GR, and impaired cytosolic GR binding capacity and GR transcriptional activity, which might be responsible for the activation of the inflammasome-induced inflammatory cascade. Cesium 21-23 progesterone receptor Mus musculus 56-59 30776325-11 2019 Diethylstilbestrol exposure during P0-P6 and P7-P13 increased POA PR and ERbeta, and decreased POA ERalpha and ARC kisspeptin levels at P7 and/or P14 in both sexes of KO mice. Diethylstilbestrol 0-18 progesterone receptor Mus musculus 66-68 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Mifepristone 37-49 progesterone receptor Mus musculus 104-125 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Mifepristone 37-49 progesterone receptor Mus musculus 127-130 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Mifepristone 51-56 progesterone receptor Mus musculus 104-125 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Mifepristone 51-56 progesterone receptor Mus musculus 127-130 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Steroids 71-78 progesterone receptor Mus musculus 104-125 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Steroids 71-78 progesterone receptor Mus musculus 127-130 31566189-6 2019 The Pgr mRNA level was significantly increased in the P4-, OP- and BPA-treated groups. bisphenol A 67-70 progesterone receptor Mus musculus 4-7 30959372-8 2019 RESULTS: Vitamin D3 significantly increased the expression of mPR alpha and mPR beta on the surface of CD4+ T cells (p <= 0.05). Cholecalciferol 9-19 progesterone receptor Mus musculus 76-84 30654718-4 2019 Second in mice lacking PR-B ( Pgrtm20mc), the number of cells that expressed the PR-A isoform were maintained during this period of prepartum cervix remodeling. pgrtm20mc 30-39 progesterone receptor Mus musculus 23-27 30328351-5 2018 Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Progesterone 0-12 progesterone receptor Mus musculus 92-113 30328351-5 2018 Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Progesterone 0-12 progesterone receptor Mus musculus 149-170 29382742-0 2018 5alpha-dihydrotestosterone reduces renal Cyp24a1 expression via suppression of progesterone receptor. Dihydrotestosterone 0-26 progesterone receptor Mus musculus 79-100 30057971-8 2018 The two highest doses of oxybenzone similarly induced an intermediate phenotype for expression of progesterone receptor. oxybenzone 25-35 progesterone receptor Mus musculus 98-119 29902902-9 2018 Western blot analysis showed that Yunkang oral liquid and progesterone can significantly increase the expressions of PRLR, PR in the uterine decidua of RSA mice, and the expression of ER in Yunkang group was higher than that in progesterone group. yunkang 34-41 progesterone receptor Mus musculus 117-119 29902902-9 2018 Western blot analysis showed that Yunkang oral liquid and progesterone can significantly increase the expressions of PRLR, PR in the uterine decidua of RSA mice, and the expression of ER in Yunkang group was higher than that in progesterone group. Progesterone 58-70 progesterone receptor Mus musculus 117-119 29308626-4 2018 The aim of the present study was to investigate if melatonin could regulate hyaluronan synthase-2 (HAS2) and Progesterone receptor (PGR) expressions in the cumulus cells of mice oocytes and provide an in vitro fertilization (IVF) approach. Melatonin 51-60 progesterone receptor Mus musculus 109-130 29308626-4 2018 The aim of the present study was to investigate if melatonin could regulate hyaluronan synthase-2 (HAS2) and Progesterone receptor (PGR) expressions in the cumulus cells of mice oocytes and provide an in vitro fertilization (IVF) approach. Melatonin 51-60 progesterone receptor Mus musculus 132-135 29308626-11 2018 RESULTS: The results of this study showed that HAS2 and PGR expressions in the cumulus cells of the mice receiving melatonin increased in comparison to the control groups. Melatonin 115-124 progesterone receptor Mus musculus 56-59 29308626-14 2018 Thus, it is concluded that fertility outcomes can be improved by melatonin it enhances PGR. Melatonin 65-74 progesterone receptor Mus musculus 87-90 29705365-4 2018 Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity. Progesterone 52-64 progesterone receptor Mus musculus 0-21 29705365-4 2018 Progesterone receptor isoforms collectively mediate progesterone signaling via their distinct and common downstream target genes, which makes the stoichiometry of isoforms relevant in modifying the progesterone activity. Progesterone 198-210 progesterone receptor Mus musculus 0-21 29382742-4 2018 Our results revealed that exposing orchidectomized mice to DHT inhibited the expression of progesterone receptor (Pgr) with or without estrogen receptor alpha expression, the latter was confirmed by ER-positive (MCF7 and T47D) or -negative (PCT) cells analysis. Dihydrotestosterone 59-62 progesterone receptor Mus musculus 91-112 29382742-4 2018 Our results revealed that exposing orchidectomized mice to DHT inhibited the expression of progesterone receptor (Pgr) with or without estrogen receptor alpha expression, the latter was confirmed by ER-positive (MCF7 and T47D) or -negative (PCT) cells analysis. Dihydrotestosterone 59-62 progesterone receptor Mus musculus 114-117 29382742-6 2018 When male kidneys preferentially hydroxylate 25-hydroxyvitamin D3 using 24-hydroxylase rather than 25-hydroxyvitamin D3-1-alpha hydroxylase, DHT suppressed the Pgr-mediated 24-hydroxylase expression, and it is important to note that DHT increased the blood 25-hydroxyvitamin D3 levels. Calcifediol 45-65 progesterone receptor Mus musculus 160-163 29382742-6 2018 When male kidneys preferentially hydroxylate 25-hydroxyvitamin D3 using 24-hydroxylase rather than 25-hydroxyvitamin D3-1-alpha hydroxylase, DHT suppressed the Pgr-mediated 24-hydroxylase expression, and it is important to note that DHT increased the blood 25-hydroxyvitamin D3 levels. Dihydrotestosterone 141-144 progesterone receptor Mus musculus 160-163 29382742-7 2018 These findings uncover an important link between androgens and vitamin D homeostasis and suggest that therapeutic modulation of Pgr may be used to treat vitamin D deficiency and related disorders. Vitamin D 63-72 progesterone receptor Mus musculus 128-131 29249975-7 2017 Similar to the effect from AR silencing, fluoride also upregulated Pgr in ALCs, but downregulated Klk4. Fluorides 41-49 progesterone receptor Mus musculus 67-70 28689771-0 2018 Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: Comparative studies with metformin. Tacrolimus 23-33 progesterone receptor Mus musculus 90-111 28689771-8 2018 Therapeutic interventions with tacrolimus or metformin normalized the expression of decidual IFNgamma, PGR and FKBP52, increased co-localization of protein inhibitor of activated STATy (PIASy) to PGR and resulted in the upregulation of uterine IL11and LIF. Tacrolimus 31-41 progesterone receptor Mus musculus 103-106 28689771-8 2018 Therapeutic interventions with tacrolimus or metformin normalized the expression of decidual IFNgamma, PGR and FKBP52, increased co-localization of protein inhibitor of activated STATy (PIASy) to PGR and resulted in the upregulation of uterine IL11and LIF. Tacrolimus 31-41 progesterone receptor Mus musculus 196-199 28689771-8 2018 Therapeutic interventions with tacrolimus or metformin normalized the expression of decidual IFNgamma, PGR and FKBP52, increased co-localization of protein inhibitor of activated STATy (PIASy) to PGR and resulted in the upregulation of uterine IL11and LIF. Metformin 45-54 progesterone receptor Mus musculus 103-106 28689771-8 2018 Therapeutic interventions with tacrolimus or metformin normalized the expression of decidual IFNgamma, PGR and FKBP52, increased co-localization of protein inhibitor of activated STATy (PIASy) to PGR and resulted in the upregulation of uterine IL11and LIF. Metformin 45-54 progesterone receptor Mus musculus 196-199 28689771-10 2018 To our knowledge this is the first report to show that the impact of HFD on the hemochorial implantation is at least in part mediated through disruption of PGR signaling at nidation and that immunosuppression with tacrolimus or treatment with metformin restores PGR-mediated influences during implantation in the obese and diabetic subjects. Metformin 243-252 progesterone receptor Mus musculus 156-159 28689771-10 2018 To our knowledge this is the first report to show that the impact of HFD on the hemochorial implantation is at least in part mediated through disruption of PGR signaling at nidation and that immunosuppression with tacrolimus or treatment with metformin restores PGR-mediated influences during implantation in the obese and diabetic subjects. Metformin 243-252 progesterone receptor Mus musculus 262-265 28701790-5 2017 Here, we identify a molecular mechanism by which progesterone promotes neurite outgrowth through mPRbeta (Paqr8) activation. Progesterone 49-61 progesterone receptor Mus musculus 97-104 28911214-6 2017 Wild-type and progesterone receptor (PR) knockout mice were treated with progesterone, and their uteri were assessed for levels of GREB1 expression. Progesterone 14-26 progesterone receptor Mus musculus 37-39 28911214-16 2017 This increase was significantly reduced in the uteri of PR knock-out mice (P < 0.01), in HESCs treated with the PR antagonist RU486 (P < 0.01), or in HESCs in which PR expression was knocked down (P < 0.05). Mifepristone 129-134 progesterone receptor Mus musculus 115-117 28911214-16 2017 This increase was significantly reduced in the uteri of PR knock-out mice (P < 0.01), in HESCs treated with the PR antagonist RU486 (P < 0.01), or in HESCs in which PR expression was knocked down (P < 0.05). Mifepristone 129-134 progesterone receptor Mus musculus 115-117 27786501-8 2016 Our results show that both facilitation and sequential inhibition of lordosis induced by progesterone require the presence of the progesterone receptor. Progesterone 89-101 progesterone receptor Mus musculus 130-151 28424251-7 2017 This function is achieved by enhancing the Src kinase-mediated ERalpha tyrosine phosphorylation, which facilitates ERalpha binding to Pgr promoter in an ERK-independent manner in periimplantation uteri. Tyrosine 71-79 progesterone receptor Mus musculus 134-137 27511308-9 2017 These results suggest that PR overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction. Progesterone 94-106 progesterone receptor Mus musculus 27-29 26676302-7 2016 After 12 h of estradiol exposure, a downregulation of this PR isoform was associated with a decrease of specific protein 1, histone 3 lysine 4 trimethylation, and RNA polymerase II occupancy on PR-B promoter, without changes in DNA methylation and hydroxymethylation. Estradiol 14-23 progesterone receptor Mus musculus 194-198 27500900-5 2016 Using co-immunoprecipitation assays, we observed the constitutive activation of nuclear factor kappa-b (NF-kappaB) p65 and its interaction with the progesterone receptor (PGR); moreover, transcriptional activity of the PGR was also repressed by NF-kappaB activity in primary mouse and human decidual stromal cells that mimic progesterone maintenance. Progesterone 148-160 progesterone receptor Mus musculus 171-174 27500900-5 2016 Using co-immunoprecipitation assays, we observed the constitutive activation of nuclear factor kappa-b (NF-kappaB) p65 and its interaction with the progesterone receptor (PGR); moreover, transcriptional activity of the PGR was also repressed by NF-kappaB activity in primary mouse and human decidual stromal cells that mimic progesterone maintenance. Progesterone 148-160 progesterone receptor Mus musculus 219-222 26676302-7 2016 After 12 h of estradiol exposure, a downregulation of this PR isoform was associated with a decrease of specific protein 1, histone 3 lysine 4 trimethylation, and RNA polymerase II occupancy on PR-B promoter, without changes in DNA methylation and hydroxymethylation. Estradiol 14-23 progesterone receptor Mus musculus 59-61 26676302-7 2016 After 12 h of estradiol exposure, a downregulation of this PR isoform was associated with a decrease of specific protein 1, histone 3 lysine 4 trimethylation, and RNA polymerase II occupancy on PR-B promoter, without changes in DNA methylation and hydroxymethylation. Lysine 134-140 progesterone receptor Mus musculus 59-61 26447367-13 2016 In this work, we identify "Progesterone Receptor Membrane Component 1" as the major progesterone receptor eliciting the protective effects of Norgestrel, both in vitro and ex vivo. Norgestrel 142-152 progesterone receptor Mus musculus 27-48 27022677-5 2016 Upon further analyses, we found that the expression of progesterone receptor (PGR) and its downstream target gene, HAND2 (heart and neural crest derivatives expressed 2), was markedly suppressed in BPA-exposed uterine tissues. bisphenol A 198-201 progesterone receptor Mus musculus 55-76 27022677-5 2016 Upon further analyses, we found that the expression of progesterone receptor (PGR) and its downstream target gene, HAND2 (heart and neural crest derivatives expressed 2), was markedly suppressed in BPA-exposed uterine tissues. bisphenol A 198-201 progesterone receptor Mus musculus 78-81 27022677-7 2016 Interestingly, we observed that down-regulation of PGR and HAND2 expression in uterine stroma upon BPA exposure was associated with enhanced activation of fibroblast growth factor and MAPK signaling in the epithelium, thus contributing to aberrant proliferation and lack of uterine receptivity. bisphenol A 99-102 progesterone receptor Mus musculus 51-54 27022677-9 2016 In summary, our studies revealed that chronic exposure to BPA impairs PGR-HAND2 pathway and adversely affects implantation and the establishment of pregnancy. bisphenol A 58-61 progesterone receptor Mus musculus 70-73 27007157-3 2016 We found that epithelial PR was required for induction of apoptosis and suppression of cell proliferation by progesterone (P4) in the cervical and vaginal epithelium. Progesterone 109-121 progesterone receptor Mus musculus 25-27 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 53-74 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 76-78 26804062-1 2016 The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. Progesterone 20-32 progesterone receptor Mus musculus 99-103 26676302-0 2016 Estradiol differentially induces progesterone receptor isoforms expression through alternative promoter regulation in a mouse embryonic hypothalamic cell line. Estradiol 0-9 progesterone receptor Mus musculus 33-54 26676302-5 2016 PR-B expression was transiently induced by estradiol after 6 h of treatment in an estrogen receptor alpha (ERalpha)-dependent manner. Estradiol 43-52 progesterone receptor Mus musculus 0-4 26676302-6 2016 This induction was associated with an increase in ERalpha phosphorylation (serine 118) and its recruitment to PR-B promoter. Serine 75-81 progesterone receptor Mus musculus 110-114 26447367-13 2016 In this work, we identify "Progesterone Receptor Membrane Component 1" as the major progesterone receptor eliciting the protective effects of Norgestrel, both in vitro and ex vivo. Norgestrel 142-152 progesterone receptor Mus musculus 84-105 26369614-3 2015 We also demonstrated the role of the progesterone receptor (PR) in inhibiting inflammation and reactive gliosis, and in enhancing the survival of oligodendrocyte progenitors cells (OPC) in injured PR knockout (PRKO) mice receiving progesterone. Progesterone 37-49 progesterone receptor Mus musculus 60-62 26275946-10 2015 Finally, by in silico analysis, we identified that mPRalpha, mPRbeta and mPRgamma promoters contain several progesterone and estrogen response elements. Progesterone 108-120 progesterone receptor Mus musculus 61-68 26349009-0 2015 The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration. ST 1435 34-43 progesterone receptor Mus musculus 4-25 26349009-2 2015 To prevent development of these abnormalities, we employed Nestorone, a high-affinity progesterone receptor agonist endowed with neuroprotective, promyelinating and anti-inflammatory activities in experimental brain ischemia, preventing neuroinflammation and chemical degeneration. ST 1435 59-68 progesterone receptor Mus musculus 86-107 26369614-8 2015 Our results support a role of PR in: (a) the anti-inflammatory effects of progesterone; (b) the modulation of astrocyte and microglial responses and (c) the prevention of OPC apoptosis, a mechanism that would enhance the commitment of progenitors to the remyelination pathway in the injured spinal cord. Progesterone 74-86 progesterone receptor Mus musculus 30-32 25904015-2 2015 Steroid hormone-responsive tissues express multiple KLFs that are linked to progesterone receptor (PGR) and estrogen receptor (ESR) actions either as integrators or as coregulators. Steroids 0-15 progesterone receptor Mus musculus 76-97 26465008-0 2015 Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus Estrogens act in brain to profoundly influence neurogenesis, sexual differentiation, neuroprotection, cognition, energy homeostasis, and female reproductive behavior and physiology through a variety of mechanisms, including the induction of progestin receptors (PRs). Estradiol 0-9 progesterone receptor Mus musculus 66-70 26465008-7 2015 In summary, these novel findings indicate that estrogens differentially regulate PR-A and PR-B expression in the female hypothalamus, and provide a mechanism by which steroid action in brain can selectively modulate behavior and physiology. Steroids 167-174 progesterone receptor Mus musculus 90-94 26247969-10 2015 In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR) and estrogen receptor alpha (ERalpha) were abnormal. Folic Acid 69-75 progesterone receptor Mus musculus 49-51 25904015-2 2015 Steroid hormone-responsive tissues express multiple KLFs that are linked to progesterone receptor (PGR) and estrogen receptor (ESR) actions either as integrators or as coregulators. Steroids 0-15 progesterone receptor Mus musculus 99-102 25730107-6 2015 As with kisspeptin neurons in vivo, 17beta-estradiol (E2) induced kisspeptin and PR in mHypoA51s. Estradiol 36-52 progesterone receptor Mus musculus 81-83 25882702-0 2015 Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Dexamethasone 8-21 progesterone receptor Mus musculus 78-99 25882702-0 2015 Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Dexamethasone 8-21 progesterone receptor Mus musculus 101-103 25882702-0 2015 Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Dexamethasone 8-21 progesterone receptor Mus musculus 114-116 25882702-2 2015 This study determined the roles of progesterone receptor and estrogen receptor 1 (PR and ESR1, respectively) in P4- and Dex-induced inhibition of LE proliferation using PR knockout (PRKO) and Esr1 knockout (Esr1KO) mice. Dexamethasone 120-123 progesterone receptor Mus musculus 82-84 25882702-9 2015 In summary, inhibitory Dex effects on LE proliferation occur partially through non-PR-mediated mechanisms, presumably GR, as indicated by Dex inhibition of LE proliferation in PRKOs. Dexamethasone 23-26 progesterone receptor Mus musculus 83-85 25550522-9 2015 Additionally, this ARN GABA population showed significantly less colocalization with progesterone receptor in PNA animals compared with controls. gamma-Aminobutyric Acid 23-27 progesterone receptor Mus musculus 85-106 25470578-4 2015 The correspondence between lowered LHbeta levels in the brain and mPRbeta in the ovary is suggestive of a possible functional association as positive correlations between LHbeta and mPR levels have been demonstrated in other fish species. Luteinizing Hormone, beta Subunit 35-41 progesterone receptor Mus musculus 66-73 25470578-4 2015 The correspondence between lowered LHbeta levels in the brain and mPRbeta in the ovary is suggestive of a possible functional association as positive correlations between LHbeta and mPR levels have been demonstrated in other fish species. Luteinizing Hormone, beta Subunit 171-177 progesterone receptor Mus musculus 66-73 25470578-7 2015 Overall, this study showed that exposure to a natural progestogen (progesterone) and synthetic progestin (norethindrone), was capable of modulating LHbeta (in brain) and mPRbeta expression (in ovary). Norethindrone 106-119 progesterone receptor Mus musculus 170-177 25791982-4 2015 First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr. Triiodothyronine 24-40 progesterone receptor Mus musculus 76-79 25791982-4 2015 First, we observed that triiodothyronine (T3) inhibited the E2 induction of Pgr and Oxtr. Triiodothyronine 42-44 progesterone receptor Mus musculus 76-79 25333515-0 2014 A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Serine 75-81 progesterone receptor Mus musculus 50-71 25200475-0 2014 Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis. ST 1435 56-65 progesterone receptor Mus musculus 26-47 24605828-13 2014 Furthermore, levels of FOXO1 and progesterone receptor increased in lesions of mice receiving MK-2206. MK 2206 94-101 progesterone receptor Mus musculus 33-54 24877640-5 2014 When the administrated dose of SOPH was 600 mg/kg per day, great changes were observed in the exposed uterine morphology and up-regulated progesterone receptor (PR) and down-regulated estrogen receptor alpha (ERalpha), E-cadherin, matrix metalloproteinase-2 (MMP-2) and integrin beta3 were also found in SOPH-exposed uterine. sophoricoside 31-35 progesterone receptor Mus musculus 138-159 24492488-11 2014 Treatment with EGCG increased these neurons in conjunction with improved hyperalgesia, reduced the expression of p-p65, cycloxygenase 2, oxytocin receptor, collagen I and IV, and transient receptor potential vanilloid type 1 in ectopic endometrium or myometrium, reduced the number of macrophages infiltrating into the ectopic endometrium while elevated the expression of progesterone receptor isoform B. epigallocatechin gallate 15-19 progesterone receptor Mus musculus 372-393 24916968-2 2014 Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while its activating ligand, progesterone, surges to peak levels as ovulation approaches. Progesterone 120-132 progesterone receptor Mus musculus 0-21 24916968-2 2014 Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while its activating ligand, progesterone, surges to peak levels as ovulation approaches. Progesterone 120-132 progesterone receptor Mus musculus 23-26 24877640-5 2014 When the administrated dose of SOPH was 600 mg/kg per day, great changes were observed in the exposed uterine morphology and up-regulated progesterone receptor (PR) and down-regulated estrogen receptor alpha (ERalpha), E-cadherin, matrix metalloproteinase-2 (MMP-2) and integrin beta3 were also found in SOPH-exposed uterine. sophoricoside 31-35 progesterone receptor Mus musculus 161-163 25477995-6 2014 We also observed negative correlations between pGR(S220)/(S234) and p38 mitogen-activated protein kinase (p38MAPK) phosphorylation, which was decreased by CAPE treatment. caffeic acid phenethyl ester 155-159 progesterone receptor Mus musculus 47-50 24680886-4 2014 We used a Plp1 transgenic PMD mouse model to test the therapeutic effect of Lonaprisan, an antagonist of the nuclear progesterone receptor, in lowering Plp1 mRNA overexpression. lonaprisan 76-86 progesterone receptor Mus musculus 117-138 24489989-5 2014 Moreover, analysis of the uterine phenotypes of ERalpha/ERbeta and PRA/PRB knockout mice indicates that different ER subtypes and PR isoforms mediate distinct responses to steroid hormones and play different roles in uterine function. Steroids 172-188 progesterone receptor Mus musculus 71-74 23744837-1 2013 Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. Progesterone 0-12 progesterone receptor Mus musculus 33-54 24065879-1 2013 It is clear from studies using progesterone receptor (PGR) mutant mice that not all of the actions of progesterone (P4) are mediated by this receptor. Progesterone 31-43 progesterone receptor Mus musculus 54-57 23827354-5 2013 Immunoblotting assays indicated that either PR agonist progesterone (P4) or PR-B over-expression promoted the PIC-induced reinforces of extracellular-signal-regulated kinase 1/2 phosphorylation (p-Erk) and protein 53 (p53), and the attenuations of protein kinase B phosphorylation (p-AKT) and tumor necrosis factor receptor-associated factor 2 (TRAF2). Progesterone 55-67 progesterone receptor Mus musculus 44-46 23867473-8 2013 Notably, the Pgr antagonist RU486 abrogated Epim-induced ductal side branching, mammary epithelial cell proliferation, and bud formation. Mifepristone 28-33 progesterone receptor Mus musculus 13-16 23744837-1 2013 Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. Progesterone 0-12 progesterone receptor Mus musculus 56-58 23744837-6 2013 Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. Progesterone 74-86 progesterone receptor Mus musculus 20-22 23744837-6 2013 Stromal deletion of PR as a single genetic change in these tumors induced progesterone resistance indicating that paracrine signaling through the stroma is essential for the progesterone therapeutic effects. Progesterone 174-186 progesterone receptor Mus musculus 20-22 23744837-9 2013 Add-back of stromal PR expressed from a constitutively active promoter sensitized these tumors to progesterone therapy. Progesterone 98-110 progesterone receptor Mus musculus 20-22 23744837-11 2013 Our findings suggest that epigenetic derepression of stromal PR could be a potential therapeutic target for sensitizing hormone-refractory endometrial tumors to progesterone therapy. Progesterone 161-173 progesterone receptor Mus musculus 61-63 23531596-9 2013 The expression of stromal PR was decreased during decidualization and preimplantation period in Stat3(d/d) mice, and PR target genes were significantly down-regulated after progesterone induction. Progesterone 173-185 progesterone receptor Mus musculus 117-119 23705924-6 2013 RESULTS: P, acting specifically through the progesterone receptor, induced increases in mammary gland proliferation and EB formation that were associated with increased AREG expression in ducts and EBs. ethylbenzene 198-201 progesterone receptor Mus musculus 44-65 23702927-3 2013 Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Progesterone 6-18 progesterone receptor Mus musculus 29-31 23317878-4 2013 The MTT assay showed that the presence of progesterone in the culture media lead to a proliferative effect that was blocked by Ru 486, an inhibitor of progesterone receptor; and ALK-5 did not participate in this effect. Mifepristone 127-133 progesterone receptor Mus musculus 151-172 23741500-5 2013 Progesterone receptor (PR) antagonist RU486 blocked the upregulation of Npl in both preimplantation uterus and P4-treated ovariectomized uterus. Mifepristone 38-43 progesterone receptor Mus musculus 0-21 23741500-5 2013 Progesterone receptor (PR) antagonist RU486 blocked the upregulation of Npl in both preimplantation uterus and P4-treated ovariectomized uterus. Mifepristone 38-43 progesterone receptor Mus musculus 23-25 22993382-2 2012 Previously, we showed that the transcription factor Kruppel-like factor (KLF) 9 is a progesterone receptor (PGR) coactivator in the uterus and that mice null for Klf9 exhibit subfertility and reduced progesterone sensitivity. Progesterone 85-97 progesterone receptor Mus musculus 108-111 23853655-8 2013 FST-induced downregulation of cAMP-responsive element binding protein phosphorylation at S133 (pCREB) was restored by propolis extract, showing a strong and positive relationship between pCREB and pGR(S220)/(S234) ratio. Cyclic AMP 30-34 progesterone receptor Mus musculus 197-200 23810007-1 2013 Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. Progesterone 102-114 progesterone receptor Mus musculus 0-21 23810007-1 2013 Progesterone receptor (PR) belongs to the superfamily of steroid receptors and mediates the action of progesterone in its target tissues. Progesterone 102-114 progesterone receptor Mus musculus 23-25 22910029-7 2012 The inhibitory effect of R5020 on tubulogenesis was likely mediated through progesterone receptor (PR) isoform A (PRA), because PRA is the predominant PR isoform expressed in the organoids, and the progestin-induced effect was prevented by the PR antagonist RU486. Promegestone 25-30 progesterone receptor Mus musculus 76-97 22910029-7 2012 The inhibitory effect of R5020 on tubulogenesis was likely mediated through progesterone receptor (PR) isoform A (PRA), because PRA is the predominant PR isoform expressed in the organoids, and the progestin-induced effect was prevented by the PR antagonist RU486. Promegestone 25-30 progesterone receptor Mus musculus 99-101 22910029-7 2012 The inhibitory effect of R5020 on tubulogenesis was likely mediated through progesterone receptor (PR) isoform A (PRA), because PRA is the predominant PR isoform expressed in the organoids, and the progestin-induced effect was prevented by the PR antagonist RU486. Mifepristone 258-263 progesterone receptor Mus musculus 76-97 22910029-7 2012 The inhibitory effect of R5020 on tubulogenesis was likely mediated through progesterone receptor (PR) isoform A (PRA), because PRA is the predominant PR isoform expressed in the organoids, and the progestin-induced effect was prevented by the PR antagonist RU486. Mifepristone 258-263 progesterone receptor Mus musculus 99-101 22638070-5 2012 Sequence analysis revealed that approximately 73% of these binding sites contain a progesterone response element or a half-site motif recognized by the PR. Progesterone 83-95 progesterone receptor Mus musculus 152-154 22778216-7 2012 Treatment of ovariectomized female rats with E(2) benzoate increased mPRbeta immunoreactivity within the medial septum but not the medial POA, horizontal diagonal band, or oculomotor nucleus. e(2) benzoate 45-58 progesterone receptor Mus musculus 69-76 22525525-8 2012 Microinjection of goldfish oocytes with a morpholino antisense oligonucleotide to mPRbeta blocked the induction of oocyte maturational competence, whereas injection of antisense oligonucleotides to mPRgamma-1 and gamma-2 were ineffective. Morpholinos 42-52 progesterone receptor Mus musculus 82-89 22525525-8 2012 Microinjection of goldfish oocytes with a morpholino antisense oligonucleotide to mPRbeta blocked the induction of oocyte maturational competence, whereas injection of antisense oligonucleotides to mPRgamma-1 and gamma-2 were ineffective. Oligonucleotides 63-78 progesterone receptor Mus musculus 82-89 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Steroids 12-19 progesterone receptor Mus musculus 53-74 22669982-10 2012 Classic estrogen-induced regulation of the progesterone receptor gene was demonstrated by increased (18)F-FFNP uptake of estradiol-treated SSM3 tumors. Estradiol 121-130 progesterone receptor Mus musculus 43-64 22465781-10 2012 Microinjection of goldfish oocytes with a morpholino antisense oligonucleotide to mPRbeta blocked the induction of oocyte maturational competence, whereas injection of antisense oliogonucleotides to mPRgamma-1 and gamma-2 were ineffective. Morpholinos 42-52 progesterone receptor Mus musculus 82-89 22465781-10 2012 Microinjection of goldfish oocytes with a morpholino antisense oligonucleotide to mPRbeta blocked the induction of oocyte maturational competence, whereas injection of antisense oliogonucleotides to mPRgamma-1 and gamma-2 were ineffective. Oligonucleotides 63-78 progesterone receptor Mus musculus 82-89 22427346-2 2012 The PR antagonist mifepristone/RU486 has been used primarily as an abortifacient possessing high affinity for both the PR and glucocorticoid receptors (GR). Mifepristone 18-30 progesterone receptor Mus musculus 4-6 22427346-2 2012 The PR antagonist mifepristone/RU486 has been used primarily as an abortifacient possessing high affinity for both the PR and glucocorticoid receptors (GR). Mifepristone 31-36 progesterone receptor Mus musculus 4-6 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Steroids 12-19 progesterone receptor Mus musculus 76-78 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Progesterone 20-32 progesterone receptor Mus musculus 53-74 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Progesterone 20-32 progesterone receptor Mus musculus 76-78 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Progesterone 12-24 progesterone receptor Mus musculus 167-188 22911820-5 2012 Ishikawa cells stably transfected with progesterone receptor B (PRB23 cells) were treated with the AKT inhibitor, MK-2206, which effectively decreased levels of p(Ser473)-AKT in a dose-dependent (10 nM to 1 uM) and time-dependent manner (0.5 h to 24 h). MK 2206 114-121 progesterone receptor Mus musculus 39-62 22911820-7 2012 Additionally, MK-2206 treatment of PRB23 cells resulted in a significant increase in levels of progesterone receptor B (PRB) protein. MK 2206 14-21 progesterone receptor Mus musculus 95-118 22911820-7 2012 Additionally, MK-2206 treatment of PRB23 cells resulted in a significant increase in levels of progesterone receptor B (PRB) protein. MK 2206 14-21 progesterone receptor Mus musculus 35-38 21934603-3 2012 We have shown for the first time that a water-soluble extract of taro (TE) potently inhibits lung-colonizing ability and spontaneous metastasis from mammary gland-implanted tumors, in a murine model of highly metastatic estrogen receptor, progesterone receptor and Her-2/neu-negative breast cancer. Water 40-45 progesterone receptor Mus musculus 239-260 21901819-13 2011 Our findings indicate that progesterone and 17beta-estradiol induce a higher proportion of MN derived from mouse ES cells through intracellular PR and ER, respectively. Progesterone 27-39 progesterone receptor Mus musculus 144-146 21901819-13 2011 Our findings indicate that progesterone and 17beta-estradiol induce a higher proportion of MN derived from mouse ES cells through intracellular PR and ER, respectively. Estradiol 44-60 progesterone receptor Mus musculus 144-146 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Progesterone 12-24 progesterone receptor Mus musculus 190-192 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Mifepristone 205-211 progesterone receptor Mus musculus 167-188 21901819-4 2011 When 100 nM progesterone was added during differentiation, we found higher proportions of MN, compared to the control condition; coincubation of progesterone with the progesterone receptor (PR) antagonist RU-486 caused a decrease in the number of MN to a percentage even lower than controls. Mifepristone 205-211 progesterone receptor Mus musculus 190-192 21680703-5 2011 These results may be related to the opposing effects of prepubertal genistein diet on the expression of Rankl and CK5/CK18 ratio (marker of luminal epithelial cell differentiation) in the mammary gland and estrogen receptor (ER-alpha) and progesterone receptor (PgR) protein levels in the mammary tumor: these all were reduced in the WT mice or increased in Brca1(+/-) mice. Genistein 68-77 progesterone receptor Mus musculus 239-260 21680703-5 2011 These results may be related to the opposing effects of prepubertal genistein diet on the expression of Rankl and CK5/CK18 ratio (marker of luminal epithelial cell differentiation) in the mammary gland and estrogen receptor (ER-alpha) and progesterone receptor (PgR) protein levels in the mammary tumor: these all were reduced in the WT mice or increased in Brca1(+/-) mice. Genistein 68-77 progesterone receptor Mus musculus 262-265 21680703-7 2011 Our results show that upregulation of Brca1 may be required for prepubertal dietary genistein exposure to reduce later mammary tumorigenesis, perhaps because in the absence of this upregulation, mice do not exhibit genistein-induced downregulation of ER-alpha, PgR, and Rankl. Genistein 84-93 progesterone receptor Mus musculus 261-264 21536547-5 2011 The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. triciribine 4-15 progesterone receptor Mus musculus 258-261 21163582-0 2011 Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability. telapristone acetate 33-41 progesterone receptor Mus musculus 0-21 21163582-4 2011 We administered the classic progesterone receptor antagonist mifepristone (RU-38486) and the specific progesterone receptor antagonist CDB-4124 to mice that had been primed with progesterone for five days, and found that both compounds induced FST immobility reliably, robustly, and in a dose-dependent fashion. Mifepristone 61-73 progesterone receptor Mus musculus 28-49 21163582-4 2011 We administered the classic progesterone receptor antagonist mifepristone (RU-38486) and the specific progesterone receptor antagonist CDB-4124 to mice that had been primed with progesterone for five days, and found that both compounds induced FST immobility reliably, robustly, and in a dose-dependent fashion. telapristone acetate 135-143 progesterone receptor Mus musculus 102-123 21536547-5 2011 The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. triciribine 4-15 progesterone receptor Mus musculus 279-282 21536547-5 2011 The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. tipifarnib 16-26 progesterone receptor Mus musculus 258-261 21536547-5 2011 The triciribine/tipifarnib synergistic effects are seen with several cancer cell lines including those from breast, leukemia, multiple myeloma and lung tumors with different genetic alterations such as K-Ras, B-Raf, PI3K (phosphoinositide 3-kinase), p53 and pRb mutations, PTEN, pRB and Ink4a deletions, and ErbB receptor overexpression. tipifarnib 16-26 progesterone receptor Mus musculus 279-282 21093581-5 2011 Our studies indicate that developmental exposure of either parent to TCDD is associated with preterm birth in a subsequent adult pregnancy due to altered PR expression and placental inflammation. Polychlorinated Dibenzodioxins 69-73 progesterone receptor Mus musculus 154-156 21291956-5 2011 The administration of RU-486, a progesterone receptor (PR) antagonist, into pregnant mice adversely affects the localization and expression of claudin-3 and claudin-4 in the amniotic epithelium. Mifepristone 22-28 progesterone receptor Mus musculus 32-53 21291956-5 2011 The administration of RU-486, a progesterone receptor (PR) antagonist, into pregnant mice adversely affects the localization and expression of claudin-3 and claudin-4 in the amniotic epithelium. Mifepristone 22-28 progesterone receptor Mus musculus 55-57 20440553-4 2011 Using the medroxyprogesterone acetate (MPA)-induced breast cancer mouse model, we have previously demonstrated that antiprogestin-responsive tumors show a higher expression level of PR isoform A (PRA) than PR isoform B (PRB), while tumors with constitutive or acquired resistance show a higher expression level of PRB. Medroxyprogesterone Acetate 10-37 progesterone receptor Mus musculus 206-218 20440553-4 2011 Using the medroxyprogesterone acetate (MPA)-induced breast cancer mouse model, we have previously demonstrated that antiprogestin-responsive tumors show a higher expression level of PR isoform A (PRA) than PR isoform B (PRB), while tumors with constitutive or acquired resistance show a higher expression level of PRB. Medroxyprogesterone Acetate 10-37 progesterone receptor Mus musculus 220-223 20440553-4 2011 Using the medroxyprogesterone acetate (MPA)-induced breast cancer mouse model, we have previously demonstrated that antiprogestin-responsive tumors show a higher expression level of PR isoform A (PRA) than PR isoform B (PRB), while tumors with constitutive or acquired resistance show a higher expression level of PRB. Medroxyprogesterone Acetate 10-37 progesterone receptor Mus musculus 314-317 21187471-1 2010 BACKGROUND: Treatment with the progesterone receptor antagonist mifepristone has been shown to improve the length and quality of life in mice with spontaneous leukemia, breast cancer, and lung cancer. Mifepristone 64-76 progesterone receptor Mus musculus 31-52 21187471-10 2010 The hypothesis that the cancer cells have the capacity to direct local progesterone production is supported by demonstrating the benefit of a progesterone receptor antagonist in tumors restricted to males. Progesterone 71-83 progesterone receptor Mus musculus 142-163 20599497-0 2010 Bisphenol-A exposure during the period of blastocyst implantation alters uterine morphology and perturbs measures of estrogen and progesterone receptor expression in mice. bisphenol A 0-11 progesterone receptor Mus musculus 130-151 21068060-6 2010 Ovariectomised mice were treated with estradiol and progesterone to stimulate alveolar development, and with the progesterone receptor antagonist mifepristone to induce regression of the newly formed alveolar buds. Mifepristone 146-158 progesterone receptor Mus musculus 113-134 20605949-2 2010 To address this uncertainty, we developed an innovative bigenic system for the doxycycline-inducible expression of RANKL in the mammary epithelium of the progesterone receptor knockout (PRKO) mouse. Doxycycline 79-90 progesterone receptor Mus musculus 154-175 20605949-3 2010 In response to acute doxycycline exposure, RANKL is specifically expressed in the estrogen receptor alpha (ER) positive/progesterone receptor negative (ER(+)/PR(-)) cell type in the PRKO mammary epithelium, a cell type that is equivalent to the ER(+)/PR(+) cell type in the wild-type (WT) mammary epithelium. Doxycycline 21-32 progesterone receptor Mus musculus 120-141 20410205-2 2010 We previously showed that mice null for the progesterone receptor (PGR)-interacting protein Kruppel-like factor (KLF) 9 are subfertile and exhibit reduced uterine progesterone sensitivity. Progesterone 44-56 progesterone receptor Mus musculus 67-70 20844199-5 2010 Stimulation of the PR (with progesterone and norgestrel) by pretreatment of DCs was found to sustain IFN regulatory factor-3 phosphorylation following TLR3 ligation, but not TLR4 ligation. Progesterone 28-40 progesterone receptor Mus musculus 19-21 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. cochaperone 52-63 progesterone receptor Mus musculus 82-103 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. cochaperone 52-63 progesterone receptor Mus musculus 105-107 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. cochaperone 52-63 progesterone receptor Mus musculus 141-143 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. Progesterone 82-94 progesterone receptor Mus musculus 105-107 20713718-1 2010 Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling. Progesterone 82-94 progesterone receptor Mus musculus 141-143 20713718-2 2010 We recently showed that Fkbp52-deficient (Fkbp52(-/-)) mice have reduced uterine PR responsiveness and implantation failure which is rescued by excess P(4) supplementation in a genetic background-dependent manner. propiverine 151-155 progesterone receptor Mus musculus 81-83 19715581-10 2009 Treatment with estradiol rapidly down-regulated the level of mPR beta mRNA and protein in immature mice. Estradiol 15-24 progesterone receptor Mus musculus 61-69 19726735-7 2010 Edn1, Apoa1, and Cited1 were primarily regulated by PGR-A as verified by additional RT-PCR analyses, suppression by the PGR antagonist RU486, and the lack of induction by protein kinase A, protein kinase C, or epidermal growth factor (EGF)-like factors pathways. Mifepristone 135-140 progesterone receptor Mus musculus 120-123 20510622-0 2010 Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. aromatic beta-amino-ketone 0-26 progesterone receptor Mus musculus 72-93 20510622-1 2010 A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. aromatic 70-78 progesterone receptor Mus musculus 31-52 20510622-1 2010 A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. beta-amino-ketone 79-96 progesterone receptor Mus musculus 31-52 20029965-5 2010 Therefore, this conditional mouse model for PR ablation represents an invaluable resource with which to further define in a developmental and/or reproductive stage-specific manner the individual and integrative roles of distinct PR populations resident in multiple progesterone-responsive target sites. Progesterone 265-277 progesterone receptor Mus musculus 229-231 19913568-0 2010 New-D-homoandrost-4,6-diene derivatives as potent progesterone receptor antagonist. -homoandrost-4,6-diene 5-27 progesterone receptor Mus musculus 50-71 19841944-5 2009 In the ovariectomized mouse uterus, the expression of Adam12 is upregulated after progesterone treatment, which is primarily mediated by nuclear progesterone receptor. Progesterone 82-94 progesterone receptor Mus musculus 145-166 19815644-3 2009 Progesterone receptor (PGR), which mediates the biological effects of the steroid hormone progesterone, has emerged as a key regulator of ovulation in mice. steroid hormone progesterone 74-102 progesterone receptor Mus musculus 0-21 19815644-3 2009 Progesterone receptor (PGR), which mediates the biological effects of the steroid hormone progesterone, has emerged as a key regulator of ovulation in mice. steroid hormone progesterone 74-102 progesterone receptor Mus musculus 23-26 18855134-6 2009 MSC alone or MSC + tamoxifen significantly reduced ERalpha, PR and cyclin D1, Ki67 index and microvessel density while increasing apoptosis in tumor tissues. Tamoxifen 19-28 progesterone receptor Mus musculus 60-62 19428988-12 2009 These studies characterize a direct inhibitory effect of estradiol on GnRH in GnRH neurons, and a direct stimulatory effect of estradiol on PR gene expression. Estradiol 127-136 progesterone receptor Mus musculus 140-142 19661303-3 2009 The objective of the present study was to determine if treatment of mice with spontaneous murine lymphocyte leukemia with the progesterone receptor antagonist mifepristone could improve length and quality of life. Mifepristone 159-171 progesterone receptor Mus musculus 126-147 19211137-0 2009 Induction of senescence by progesterone receptor-B activation in response to cAMP in ovarian cancer cells. Cyclic AMP 77-81 progesterone receptor Mus musculus 27-48 19211137-2 2009 We previously demonstrated that the induction of PR-B by treatment with cAMP was associated with G0/G1 arrest of the cell cycle and growth inhibition in NIH 3T3 cells. Cyclic AMP 72-76 progesterone receptor Mus musculus 49-53 19211137-4 2009 METHODS: 1) The levels of PR-B and cell cycle associated proteins (p21, p27 and Rb) following treatment with cAMP in the Ras-transformed NIH3T3 cells (K12V) and ovarian cancer cell lines (SKOV cells) were investigated by Western blots. Cyclic AMP 109-113 progesterone receptor Mus musculus 26-30 19211137-6 2009 RESULTS: 1) Treatment with cAMP increased PR-B and p27 levels in K12V cells and inhibited cell growth by inducing premature senescence. Cyclic AMP 27-31 progesterone receptor Mus musculus 42-46 19211137-8 2009 2) In SKOV cells, treatment with cAMP induced PR-B, p27 and p21 expression, reduced the level of phosphorylated Rb, caused accumulation of cells in the G0/G1 fraction of the cell cycle, and induced senescence. Cyclic AMP 33-37 progesterone receptor Mus musculus 46-50 19211137-11 2009 CONCLUSION: Treatment of cAMP, through activation of PR-B, induced senescence and suppressed tumorigenicity in ovarian cancer cells. Cyclic AMP 25-29 progesterone receptor Mus musculus 53-57 19325006-6 2009 Furthermore, using both a pharmacological inhibitor of the progesterone receptor (PR) and PR knockout mice, we determined that the effects of progesterone were mediated by the classical PR. Progesterone 59-71 progesterone receptor Mus musculus 82-84 19428988-8 2009 Since estradiol has been shown to regulate progesterone receptor (PR) expression; similar studies were performed demonstrating an estradiol mediated increase in PR in both cell lines. Estradiol 6-15 progesterone receptor Mus musculus 43-64 19428988-8 2009 Since estradiol has been shown to regulate progesterone receptor (PR) expression; similar studies were performed demonstrating an estradiol mediated increase in PR in both cell lines. Estradiol 6-15 progesterone receptor Mus musculus 66-68 19428988-8 2009 Since estradiol has been shown to regulate progesterone receptor (PR) expression; similar studies were performed demonstrating an estradiol mediated increase in PR in both cell lines. Estradiol 6-15 progesterone receptor Mus musculus 161-163 19443374-1 2009 BACKGROUND: Mifepristone, a progesterone receptor antagonist has been found to improve the length and quality of life in various spontaneous murine cancer models including tumors without progesterone receptors theoretically by inhibiting an immunomodulatory protein that suppresses natural killer cell function in the tumor microenvironment. Mifepristone 12-24 progesterone receptor Mus musculus 28-49 19401525-0 2009 Short-term prophylactic tamoxifen reduces the incidence of antiestrogen-resistant/estrogen receptor-positive/progesterone receptor-negative mammary tumors. Tamoxifen 24-33 progesterone receptor Mus musculus 109-130 18692819-11 2009 In the ovariectomized mouse uterus, Gstm2 expression was strongly up-regulated by progesterone via progesterone receptor. Progesterone 82-94 progesterone receptor Mus musculus 99-120 19403993-3 2009 Pregnenolone is then metabolized to progesterone, an activator of progesterone receptor, and further metabolized to produce allopregnanolone and 3alpha,21-dihydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THDOC), positive allosteric modulators and activators of the GABA(A) receptor. Pregnenolone 0-12 progesterone receptor Mus musculus 66-87 19403993-3 2009 Pregnenolone is then metabolized to progesterone, an activator of progesterone receptor, and further metabolized to produce allopregnanolone and 3alpha,21-dihydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THDOC), positive allosteric modulators and activators of the GABA(A) receptor. Progesterone 36-48 progesterone receptor Mus musculus 66-87 18625316-0 2008 Synthesis and biological effect of halogen substituted phenyl acetic acid derivatives of progesterone as potent progesterone receptor antagonists. phenylacetic acid 55-73 progesterone receptor Mus musculus 112-133 18253697-9 2009 Progesterone suppressed MC3T3-E1 cells apoptosis induced by serum deprivation, and this effect was blocked by a PR antagonist RU486. Progesterone 0-12 progesterone receptor Mus musculus 112-114 18253697-9 2009 Progesterone suppressed MC3T3-E1 cells apoptosis induced by serum deprivation, and this effect was blocked by a PR antagonist RU486. Mifepristone 126-131 progesterone receptor Mus musculus 112-114 19014798-0 2008 A possible role of progesterone receptor in mouse oocyte in vitro fertilization regulated by norethisterone and its reduced metabolite. Norethindrone 93-107 progesterone receptor Mus musculus 19-40 18687774-9 2008 In sum, the progesterone-responsive transcriptome described herein not only reinforces the importance of progesterone in mammary epithelial expansion but also represents an invaluable information resource with which to identify novel signaling paradigms for mammary PR action. Progesterone 12-24 progesterone receptor Mus musculus 266-268 18625316-0 2008 Synthesis and biological effect of halogen substituted phenyl acetic acid derivatives of progesterone as potent progesterone receptor antagonists. Halogens 35-42 progesterone receptor Mus musculus 112-133 18625316-0 2008 Synthesis and biological effect of halogen substituted phenyl acetic acid derivatives of progesterone as potent progesterone receptor antagonists. Progesterone 89-101 progesterone receptor Mus musculus 112-133 18625316-5 2008 We evaluated six related steroidal compounds 8a-8f differing in the nature of the 17alpha ester side chain for the inhibition of [3H] R5020 binding to the PR. 17alpha ester 82-95 progesterone receptor Mus musculus 155-157 18625316-5 2008 We evaluated six related steroidal compounds 8a-8f differing in the nature of the 17alpha ester side chain for the inhibition of [3H] R5020 binding to the PR. Tritium 130-132 progesterone receptor Mus musculus 155-157 18625316-6 2008 The IC50 values for the displacement of [3H] R5020 binding to the PR and its relative binding affinities (RBAs) were determined. Tritium 41-43 progesterone receptor Mus musculus 66-68 18625316-7 2008 Progesterone and R5020 had similar IC(50) values; steroids 8a, 8f and 8c bind to the progesterone receptor with RBAs of 100%, whereas 8e, 8b and 8d have RBA values <100%. Steroids 50-58 progesterone receptor Mus musculus 85-106 18625316-9 2008 Having demonstrated in this study that steroids 8a-8f bind to the PR, we also evaluated the receptor"s selectivity, since some progesterone derivatives bind to AR, MR, GR receptors. Steroids 39-47 progesterone receptor Mus musculus 66-68 18625316-17 2008 The overall data showed that steroids 8a, 8f, 8e and 8c have a high and selective binding activity to the PR. Steroids 29-37 progesterone receptor Mus musculus 106-108 18239353-12 2008 In conclusion, LIF, which has a crucial role in E2 action for initiation of implantation, caused transient induction of Pgr mRNA and subsequent upregulation of Ihh mRNA, which mediates progesterone-Pgr actions for successful implantation. Progesterone 185-197 progesterone receptor Mus musculus 198-201 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 48-69 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 progesterone receptor Mus musculus 184-205 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 progesterone receptor Mus musculus 207-209 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 71-73 18197783-1 2008 Progesterone acting through two isoforms of the progesterone receptor (PR), PRA and PRB, regulates proliferation and differentiation in the normal mammary gland in mouse, rat, and human. Progesterone 0-12 progesterone receptor Mus musculus 84-87 17941046-0 2007 Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor. Tetracycline 18-30 progesterone receptor Mus musculus 108-129 18174919-2 2007 A selective gene-knockout approach applied to the mouse, which abrogates gene function only in cell types that express PR, recently disclosed steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) to be an indispensable coregulator for uterine and mammary gland responses that require progesterone. Progesterone 300-312 progesterone receptor Mus musculus 119-121 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Doxycycline 138-149 progesterone receptor Mus musculus 84-86 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Doxycycline 138-149 progesterone receptor Mus musculus 103-105 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Progesterone 202-214 progesterone receptor Mus musculus 84-86 17941046-4 2007 Crossed with the TZA reporter, which carries the TetO-LacZ responder transgene, the PR(+/rtTA)/TZA and PR(rtTA/rtTA)/TZA bigenics exhibit doxycycline-induced beta-galactosidase activity specifically in progesterone responsive target tissues such as the mammary gland, uterus, ovary, and pituitary gland. Progesterone 202-214 progesterone receptor Mus musculus 103-105 17941046-5 2007 In the case of the PR(+/rtTA)/TZA mammary epithelium, dual immunofluorescence demonstrated that PR expression and doxycycline-induced beta-galactosidase activity colocalized; beta-galactosidase was not detected in the absence of doxycycline. Doxycycline 114-125 progesterone receptor Mus musculus 19-21 17941046-5 2007 In the case of the PR(+/rtTA)/TZA mammary epithelium, dual immunofluorescence demonstrated that PR expression and doxycycline-induced beta-galactosidase activity colocalized; beta-galactosidase was not detected in the absence of doxycycline. Doxycycline 229-240 progesterone receptor Mus musculus 19-21 17941046-5 2007 In the case of the PR(+/rtTA)/TZA mammary epithelium, dual immunofluorescence demonstrated that PR expression and doxycycline-induced beta-galactosidase activity colocalized; beta-galactosidase was not detected in the absence of doxycycline. Doxycycline 229-240 progesterone receptor Mus musculus 96-98 17574608-9 2007 In utero ethinyl estradiol led to 8.2, 9.7 and 5.2-fold increases in progesterone receptor mRNA in females and in males with and without hypospadias, respectively. Ethinyl Estradiol 9-26 progesterone receptor Mus musculus 69-90 17574608-10 2007 Testosterone propionate significantly decreased progesterone receptor mRNA levels in females and males. Testosterone Propionate 0-23 progesterone receptor Mus musculus 48-69 17574608-13 2007 Ethinyl estradiol and testosterone propionate lead to opposing effects on progesterone receptor expression, in addition to their opposing morphological effects on the genital tubercles. Ethinyl Estradiol 0-17 progesterone receptor Mus musculus 74-95 17574608-13 2007 Ethinyl estradiol and testosterone propionate lead to opposing effects on progesterone receptor expression, in addition to their opposing morphological effects on the genital tubercles. Testosterone Propionate 22-45 progesterone receptor Mus musculus 74-95 16899559-2 2006 In this study, the mPRalpha and mPRbeta isoforms from zebrafish were shown to be rapidly and specifically activated by the maturation-inducing steroid (MIS) of this species, 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Steroids 143-150 progesterone receptor Mus musculus 32-39 17408746-9 2007 ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action. Cadmium 77-79 progesterone receptor Mus musculus 22-25 17408746-9 2007 ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action. Cadmium 77-79 progesterone receptor Mus musculus 167-170 17408746-9 2007 ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action. cd+mmi 92-98 progesterone receptor Mus musculus 22-25 17408746-9 2007 ER-alpha, ER-beta and PgR mRNA expressions were decreased in male and female Cd, and female Cd+MMI groups, respectively; among these changes the reduced expression of PgR was opposite to estrogenic action. cd+mmi 92-98 progesterone receptor Mus musculus 167-170 17317767-1 2007 In normal mouse mammary gland, the mitogenic action of progesterone (P) is mediated by two P receptor (PR) isoforms, PRA and PRB. Progesterone 55-67 progesterone receptor Mus musculus 125-128 17341305-1 2007 INTRODUCTION: Medroxyprogesterone acetate (MPA) induces estrogen receptor (ER)-positive and progesterone receptor (PR)-positive ductal invasive mammary carcinomas in BALB/c mice. Medroxyprogesterone Acetate 14-41 progesterone receptor Mus musculus 92-113 17341305-1 2007 INTRODUCTION: Medroxyprogesterone acetate (MPA) induces estrogen receptor (ER)-positive and progesterone receptor (PR)-positive ductal invasive mammary carcinomas in BALB/c mice. Medroxyprogesterone Acetate 14-41 progesterone receptor Mus musculus 115-117 16973758-11 2007 These results define a negative cross talk between PR and Stat5a/GR that may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene in the mammary gland during pregnancy. Progesterone 117-129 progesterone receptor Mus musculus 51-53 17149722-5 2006 Crossing with the ROSA26R revealed that the PR-BAC(iCre) transgenic expresses active iCre only in cell-lineages that express the PR. rosa26r 18-25 progesterone receptor Mus musculus 44-46 16887885-4 2006 To identify these pathways, we performed gene expression profiling using ovaries from mice subjected to gonadotropin-induced superovulation in the presence and in the absence of CDB-2914, a synthetic PGR antagonist. ulipristal 178-186 progesterone receptor Mus musculus 200-203 16899559-7 2006 The rank order of the potencies of several progestins in activating MAPK via mPRalpha and mPRbeta was the same (17,20beta-DHP>progesterone >4-pregnen-17,20beta,21-triol-3-one). Progesterone 129-141 progesterone receptor Mus musculus 90-97 16899559-7 2006 The rank order of the potencies of several progestins in activating MAPK via mPRalpha and mPRbeta was the same (17,20beta-DHP>progesterone >4-pregnen-17,20beta,21-triol-3-one). 4-pregnen-17,20beta 146-165 progesterone receptor Mus musculus 90-97 16899559-9 2006 This progestin significantly decreased cAMP levels in both mPRalpha- and mPRbeta-transfected cells in a dose-responsive and time-dependent manner. Cyclic AMP 39-43 progesterone receptor Mus musculus 73-80 17303655-0 2007 Distinct temporal and spatial activities of RU486 on progesterone receptor function in reproductive organs of ovariectomized mice. Mifepristone 44-49 progesterone receptor Mus musculus 53-74 17303655-1 2007 RU486 is an incomplete progesterone receptor (PR) antagonist due to its partial agonist activity. Mifepristone 0-5 progesterone receptor Mus musculus 23-44 17303655-1 2007 RU486 is an incomplete progesterone receptor (PR) antagonist due to its partial agonist activity. Mifepristone 0-5 progesterone receptor Mus musculus 46-48 17303655-3 2007 As might be expected, acute RU486 treatment (6 h after injection) reduced PR transcriptional activity in the uterus, compared with vehicle or progesterone (P4) treatments. Mifepristone 28-33 progesterone receptor Mus musculus 74-76 17303655-4 2007 Chronic RU486 treatment (3 d) had a distinctly different effect on PR-mediated transcription, elevating PR activity in both the uterus and mammary gland, whereas chronic P4 treatment reduced PR activity in both tissues. Mifepristone 8-13 progesterone receptor Mus musculus 67-69 17303655-4 2007 Chronic RU486 treatment (3 d) had a distinctly different effect on PR-mediated transcription, elevating PR activity in both the uterus and mammary gland, whereas chronic P4 treatment reduced PR activity in both tissues. Mifepristone 8-13 progesterone receptor Mus musculus 104-106 17303655-4 2007 Chronic RU486 treatment (3 d) had a distinctly different effect on PR-mediated transcription, elevating PR activity in both the uterus and mammary gland, whereas chronic P4 treatment reduced PR activity in both tissues. Mifepristone 8-13 progesterone receptor Mus musculus 104-106 17303655-7 2007 In contrast to our observations in the uterus, chronic RU486 treatment increased modified forms of PR and the SRC-3 protein levels (but not SRC-1 and SRC-2 levels) in luminal epithelial cells of the mammary gland. Mifepristone 55-60 progesterone receptor Mus musculus 99-101 18543433-6 2007 Like progesterone, RU486 also temporally regulates PR activity in female reproductive organs. Mifepristone 19-24 progesterone receptor Mus musculus 51-53 18543433-7 2007 However, the temporal regulation of PR activity by RU486 is the inverse of progesterone"s activity. Mifepristone 51-56 progesterone receptor Mus musculus 36-38 18543433-8 2007 RU486 acutely represses PR activity after injection but increases PR activity after chronic treatment in female reproductive tissues. Mifepristone 0-5 progesterone receptor Mus musculus 24-26 18543433-8 2007 RU486 acutely represses PR activity after injection but increases PR activity after chronic treatment in female reproductive tissues. Mifepristone 0-5 progesterone receptor Mus musculus 66-68 18543434-7 2007 Finally, two distinct isoforms of PRs (PR-A and PR-B) are coexpressed in the mammary gland and display extensively overlapping but partially distinct gene regulatory properties in relaying the progesterone signal. Progesterone 193-205 progesterone receptor Mus musculus 48-52 16799639-10 2006 Furthermore, we observed that inhibition of caveolin-1 expression abrogated PR capacity to induced luciferase activity from a progesterone response element-driven reporter plasmid. Progesterone 126-138 progesterone receptor Mus musculus 76-78 16959845-8 2006 This genistein dose down-regulated estrogen receptor (beta more than alpha) and progesterone receptor expression and induced estrogen-dependent adipose differentiation factors; it did not change expression of the minimal consensus estrogen-responsive element in ERE-tK-LUC mice, which was positively modulated in other tissues (e.g. the lung). Genistein 5-14 progesterone receptor Mus musculus 80-101 17003284-6 2006 Exposure of E(2)-treated pituitary cells to 200 nM progesterone for 6 h decreased both PR-A and PR-B levels in rat cells, but had no effect on PR isoform expression in mouse cells even when exposure was extended to 12 h. The low level of PR expression found in LbetaT2 gonadotropes was unaffected by E(2), alone or with progesterone. Progesterone 51-63 progesterone receptor Mus musculus 96-98 16899559-2 2006 In this study, the mPRalpha and mPRbeta isoforms from zebrafish were shown to be rapidly and specifically activated by the maturation-inducing steroid (MIS) of this species, 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). 4-pregnen-17,20beta-diol-3-one 174-204 progesterone receptor Mus musculus 32-39 16899559-2 2006 In this study, the mPRalpha and mPRbeta isoforms from zebrafish were shown to be rapidly and specifically activated by the maturation-inducing steroid (MIS) of this species, 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). 20beta-dhp 209-219 progesterone receptor Mus musculus 32-39 16899559-5 2006 Plasma membrane proteins from mPRalpha- or mPRbeta-transfected cells showed high affinity (mPRalpha, K(d) 7 nM; mPRbeta, K(d) 12 nM), saturable, displaceable, single-binding sites specific for 17,20beta-DHP, whereas negligible specific 17,20beta-DHP binding was observed in nontransfected cells. 17 alpha,20 beta-dihydroxypregn-4-en-3-one 193-206 progesterone receptor Mus musculus 43-50 16899559-5 2006 Plasma membrane proteins from mPRalpha- or mPRbeta-transfected cells showed high affinity (mPRalpha, K(d) 7 nM; mPRbeta, K(d) 12 nM), saturable, displaceable, single-binding sites specific for 17,20beta-DHP, whereas negligible specific 17,20beta-DHP binding was observed in nontransfected cells. 17 alpha,20 beta-dihydroxypregn-4-en-3-one 236-249 progesterone receptor Mus musculus 43-50 16899559-7 2006 The rank order of the potencies of several progestins in activating MAPK via mPRalpha and mPRbeta was the same (17,20beta-DHP>progesterone >4-pregnen-17,20beta,21-triol-3-one). 17 alpha,20 beta-dihydroxypregn-4-en-3-one 112-125 progesterone receptor Mus musculus 90-97 16728408-4 2006 A small interfering RNA knockdown of type I GnRH receptor levels reduced PR activation by GnRHs, while progesterone-dependent PR activation was unaffected. Progesterone 103-115 progesterone receptor Mus musculus 126-128 16813932-10 2006 CONCLUSIONS: The increase of progesterone receptor mRNA expression in males and the decrease in females as a result of exposure to medroxyprogesterone acetate, which also causes urethral abnormalities in both sexes, suggests a previously unidentified role for progesterone receptor, possibly interacting with androgen receptor, in anomalous genital tubercle development. Medroxyprogesterone Acetate 131-158 progesterone receptor Mus musculus 29-50 16813932-10 2006 CONCLUSIONS: The increase of progesterone receptor mRNA expression in males and the decrease in females as a result of exposure to medroxyprogesterone acetate, which also causes urethral abnormalities in both sexes, suggests a previously unidentified role for progesterone receptor, possibly interacting with androgen receptor, in anomalous genital tubercle development. Medroxyprogesterone Acetate 131-158 progesterone receptor Mus musculus 260-281 16413068-3 2006 We investigated the effects of PR deletion on the sensitivity of sexual behavior to dopamine antagonism in male wild-type (WT) and progesterone receptor knockout (PRKO) mice and found that WT mice were more behaviorally sensitive to the effects of dopamine D1 receptor blockade. Dopamine 84-92 progesterone receptor Mus musculus 31-33 17300041-3 2006 One group of ovariectomized mice was injected with progesterone receptor blocker Mifepristone before 2 hrs of the last treatment. Mifepristone 81-93 progesterone receptor Mus musculus 51-72 17300041-7 2006 Mifepristone decreased anxiety levels and progesterone receptor-ir cell number in both groups of mice that suggests involvement of genomic mechanisms in anxiety regulation in female mice. Mifepristone 0-12 progesterone receptor Mus musculus 42-63 15885897-4 2006 After treatment with CAPE (50 microM) for 6h, it demonstrated that the protein level of hyperphosphorylated pRb decreased, and cyclin dependent kinase inhibitors p21, p27, and p16 were marked up-regulated. caffeic acid phenethyl ester 21-25 progesterone receptor Mus musculus 108-111 16413068-7 2006 Thus, it appears that PR deletion affects the display of sexual behavior and its modulation by dopamine, as well as the differentiation of dopaminergic cells and the plasticity of those cells in response to social environment and behavioral experience. Dopamine 95-103 progesterone receptor Mus musculus 22-24 16141356-3 2006 In the mammary gland, PR activity in the luminal epithelium of both wild-type and SRC-1(-/-) mice was induced by estrogen + progesterone treatment. Progesterone 124-136 progesterone receptor Mus musculus 22-24 16504050-0 2006 Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice. vinclozolin 36-47 progesterone receptor Mus musculus 97-118 16504050-11 2006 At the molecular level, vinclozolin down-regulated estrogen receptor alpha mRNA in females and up-regulated progesterone receptor mRNA. vinclozolin 24-35 progesterone receptor Mus musculus 108-129 16504050-12 2006 Vinclozolin-exposed males exhibited up-regulated estrogen receptor alpha and progesterone receptor mRNA, effects we have also seen with exposure to the synthetic estrogen, ethinyl estradiol. vinclozolin 0-11 progesterone receptor Mus musculus 77-98 16504050-13 2006 CONCLUSION: The results suggest that vinclozolin virilizes females and directly or indirectly affects progesterone receptor expression. vinclozolin 37-48 progesterone receptor Mus musculus 102-123 16210344-0 2006 Cyclic guanosine 5"-monophosphate-dependent protein kinase II is induced by luteinizing hormone and progesterone receptor-dependent mechanisms in granulosa cells and cumulus oocyte complexes of ovulating follicles. cyclic guanosine 0-16 progesterone receptor Mus musculus 100-121 16210344-1 2006 Cyclic GMP (cGMP)-dependent protein kinase II (Prkg2, cGK II) was identified as a potential target of the progesterone receptor (Nr3c3) in the mouse ovary based on microarray analyses. Cyclic GMP 0-10 progesterone receptor Mus musculus 106-127 16210344-1 2006 Cyclic GMP (cGMP)-dependent protein kinase II (Prkg2, cGK II) was identified as a potential target of the progesterone receptor (Nr3c3) in the mouse ovary based on microarray analyses. Cyclic GMP 0-10 progesterone receptor Mus musculus 129-134 16210344-1 2006 Cyclic GMP (cGMP)-dependent protein kinase II (Prkg2, cGK II) was identified as a potential target of the progesterone receptor (Nr3c3) in the mouse ovary based on microarray analyses. Cyclic GMP 12-16 progesterone receptor Mus musculus 106-127 16210344-1 2006 Cyclic GMP (cGMP)-dependent protein kinase II (Prkg2, cGK II) was identified as a potential target of the progesterone receptor (Nr3c3) in the mouse ovary based on microarray analyses. Cyclic GMP 12-16 progesterone receptor Mus musculus 129-134 16141356-5 2006 In the uterus, PR activity in the stroma compartment of both wild-type and SRC-3(-/-) mice was induced by estrogen + progesterone treatment. Progesterone 117-129 progesterone receptor Mus musculus 15-17 16135805-7 2005 In contrast, SRC-1 was involved in the down-regulation of PR target gene expression in the luminal and glandular epithelial compartments of the uterus after chronic progesterone treatment. Progesterone 165-177 progesterone receptor Mus musculus 58-60 16223481-8 2005 Our results suggest a potentially novel mechanism of PR gene regulation within mES cells compared to adult tissues and the possibility of unique targets of PR action during early mES cell differentiation. 2-(N-morpholino)ethanesulfonic acid 79-82 progesterone receptor Mus musculus 53-55 16223481-8 2005 Our results suggest a potentially novel mechanism of PR gene regulation within mES cells compared to adult tissues and the possibility of unique targets of PR action during early mES cell differentiation. 2-(N-morpholino)ethanesulfonic acid 179-182 progesterone receptor Mus musculus 156-158 15845616-1 2005 Progesterone (P4) acting through its cognate receptor, the progesterone receptor (PR), plays an important role in uterine physiology. Progesterone 0-12 progesterone receptor Mus musculus 59-80 15845616-1 2005 Progesterone (P4) acting through its cognate receptor, the progesterone receptor (PR), plays an important role in uterine physiology. Progesterone 0-12 progesterone receptor Mus musculus 82-84 15878961-8 2005 During pregnancy there was extensive colocalization of PRB with 5-bromo-2"-deoxyuridine (BrdU) and cyclin D1; 95% of BrdU-positive cells and 83% of cyclin D1-positive cells expressed PRB. Bromodeoxyuridine 64-87 progesterone receptor Mus musculus 55-58 15878961-8 2005 During pregnancy there was extensive colocalization of PRB with 5-bromo-2"-deoxyuridine (BrdU) and cyclin D1; 95% of BrdU-positive cells and 83% of cyclin D1-positive cells expressed PRB. Bromodeoxyuridine 89-93 progesterone receptor Mus musculus 55-58 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 progesterone receptor Mus musculus 51-53 15714388-0 2005 Use of the progesterone receptor antagonist RU 486 to identify novel progesterone receptor-regulated pathways in implantation. Mifepristone 44-50 progesterone receptor Mus musculus 11-32 15714388-0 2005 Use of the progesterone receptor antagonist RU 486 to identify novel progesterone receptor-regulated pathways in implantation. Mifepristone 44-50 progesterone receptor Mus musculus 69-90 16457691-0 2005 Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice. Oligonucleotides 10-26 progesterone receptor Mus musculus 41-62 15817149-6 2005 The expression of PR-B and p27 CDK inhibitors was up-regulated by treatment with both the MEK inhibitor and cAMP. Cyclic AMP 108-112 progesterone receptor Mus musculus 18-22 15509668-8 2005 The EDs-induced expression of CaBP-9k mRNA and protein was reversed or abolished by pretreatment with RU486 or ICI 182,780, suggesting that these synthetic chemicals may have both progestogenic and estrogenic properties by acting through PR or ER in the induction of uterine CaBP-9k mRNA and protein in this model. Mifepristone 102-107 progesterone receptor Mus musculus 238-240 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 progesterone receptor Mus musculus 254-256 14688261-2 2004 Our previous studies, using high density oligonucleotide microarrays, suggested a novel link between progesterone receptor (PR) signaling and 12/15-LOX-mediated fatty acid metabolism in preimplantation mouse uterus. Fatty Acids 161-171 progesterone receptor Mus musculus 101-122 15280552-5 2004 Analysis of the reproductive phenotypes of these mice has indicated that PR-A and PR-B mediate mostly distinct but partially overlapping reproductive responses to progesterone. Progesterone 163-175 progesterone receptor Mus musculus 82-86 14982969-0 2004 Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. Progesterone 27-39 progesterone receptor Mus musculus 61-82 15234545-13 2004 These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR. 4-nonylphenol 27-42 progesterone receptor Mus musculus 189-193 15234545-13 2004 These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR. 4-octylphenol 47-62 progesterone receptor Mus musculus 189-193 14681235-3 2004 We recently utilized high-density oligonucleotide microarrays to identify several genes whose expression is markedly altered in pregnant uterus in response to RU486, a well characterized antagonist of the progesterone receptor (PR). Oligonucleotides 34-49 progesterone receptor Mus musculus 205-226 14681235-3 2004 We recently utilized high-density oligonucleotide microarrays to identify several genes whose expression is markedly altered in pregnant uterus in response to RU486, a well characterized antagonist of the progesterone receptor (PR). Oligonucleotides 34-49 progesterone receptor Mus musculus 228-230 14681235-3 2004 We recently utilized high-density oligonucleotide microarrays to identify several genes whose expression is markedly altered in pregnant uterus in response to RU486, a well characterized antagonist of the progesterone receptor (PR). Mifepristone 159-164 progesterone receptor Mus musculus 205-226 14681235-3 2004 We recently utilized high-density oligonucleotide microarrays to identify several genes whose expression is markedly altered in pregnant uterus in response to RU486, a well characterized antagonist of the progesterone receptor (PR). Mifepristone 159-164 progesterone receptor Mus musculus 228-230 14688261-2 2004 Our previous studies, using high density oligonucleotide microarrays, suggested a novel link between progesterone receptor (PR) signaling and 12/15-LOX-mediated fatty acid metabolism in preimplantation mouse uterus. Fatty Acids 161-171 progesterone receptor Mus musculus 124-126 14667967-0 2003 Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Progesterone 0-12 progesterone receptor Mus musculus 82-103 12915398-3 2003 ERalpha, ERbeta, and PR levels were higher in the aorta and ASMC of atherosclerosis-susceptible B6 mice. asmc 60-64 progesterone receptor Mus musculus 21-23 14667967-4 2003 More recently, selective ablation of the PR-A and PR-B proteins in mice had facilitated examination of the contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone 196-208 progesterone receptor Mus musculus 50-54 14667967-5 2003 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are reflected in a distinct tissue-selective contribution of the individual isoforms to the reproductive activities of progesterone. Progesterone 347-359 progesterone receptor Mus musculus 177-181 14667968-3 2003 Towards this end, the progesterone receptor knockout (PRKO) mouse demonstrated that progesterone is essential for pregnancy-associated mammary gland ductal side-branching and alveologenesis and that these morphological changes are dependent on progesterone-induced mammary epithelial proliferation. Progesterone 84-96 progesterone receptor Mus musculus 22-43 12779079-1 2003 The purpose of this study was to evaluate the effect of the selective estrogen receptor modulators raloxifene and tamoxifen and of the pure antiestrogen fulvestrant on tumor growth and progesterone receptor (PR) expression in an experimental model of breast cancer. Raloxifene Hydrochloride 99-109 progesterone receptor Mus musculus 185-206 14973372-8 2003 In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. Estradiol 41-50 progesterone receptor Mus musculus 88-92 14973372-8 2003 In ovariectomized mice supplemented with estradiol but lacking measurable progesterone, PR-B-expressing tumors grow to twice the size of PR-A-expressing ones. Progesterone 74-86 progesterone receptor Mus musculus 88-92 12846422-0 2003 Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment. Medroxyprogesterone Acetate 36-63 progesterone receptor Mus musculus 0-21 14623545-6 2003 Although, there was an insignificant increase in mammary growth in aged animals after 6 weeks of letrozole treatment, the levels of expression of estrogen receptor, progesterone receptor and genes involved in cell cycle and cell proliferation remained low compared to control untreated animals. Letrozole 97-106 progesterone receptor Mus musculus 165-186 12810572-6 2003 However, when compared with E(2), PPT was less effective in stimulating uterine weight, complement component 3, and G6PDH expression but was as effective as E(2) in regulating lactoferrin, AR, and PR expression. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 34-37 progesterone receptor Mus musculus 197-199 12810572-8 2003 Interestingly, DPN reduced the uterine weight stimulation by PPT, and enhanced the effect of PPT in decreasing uterine PR and AR mRNA. diarylpropionitrile 15-18 progesterone receptor Mus musculus 119-121 12810572-8 2003 Interestingly, DPN reduced the uterine weight stimulation by PPT, and enhanced the effect of PPT in decreasing uterine PR and AR mRNA. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 93-96 progesterone receptor Mus musculus 119-121 12779079-1 2003 The purpose of this study was to evaluate the effect of the selective estrogen receptor modulators raloxifene and tamoxifen and of the pure antiestrogen fulvestrant on tumor growth and progesterone receptor (PR) expression in an experimental model of breast cancer. Raloxifene Hydrochloride 99-109 progesterone receptor Mus musculus 208-210 12554796-3 2003 Forskolin/phorbol myristate (PMA) induced PR promoter-luciferase reporter activity in granulosa cells greater than 15-fold. Colforsin 0-9 progesterone receptor Mus musculus 42-44 12604642-3 2003 Previous studies have revealed that the cellular ratio of the PR isoforms is important for progesterone-responsive tissues and is under developmental control in different species. Progesterone 91-103 progesterone receptor Mus musculus 62-64 12604642-9 2003 Third, we demonstrated that treatment with the PR antagonist RU 486 in vivo resulted in down-regulation of both isoforms in parallel with increased activation of caspase-3, a decreased level of proliferating cell nuclear antigen, and a reduced rate of ovulation. Mifepristone 61-67 progesterone receptor Mus musculus 47-49 12554796-3 2003 Forskolin/phorbol myristate (PMA) induced PR promoter-luciferase reporter activity in granulosa cells greater than 15-fold. Phorbol 13-myristate 10-27 progesterone receptor Mus musculus 42-44 12554796-3 2003 Forskolin/phorbol myristate (PMA) induced PR promoter-luciferase reporter activity in granulosa cells greater than 15-fold. Tetradecanoylphorbol Acetate 29-32 progesterone receptor Mus musculus 42-44 12648519-5 2003 In vitro, medroxyprogesterone acetate (MPA) was stimulatory along a biphasic curve with two slopes, one at very low concentrations (EC(50): 1.5 +/- 0.7 fM) and the other at values compatible with the described K(d) for the PR (EC(50): 0.33 +/- 0.3 nM). Medroxyprogesterone Acetate 10-37 progesterone receptor Mus musculus 223-225 12591170-4 2003 Previously high progesterone levels have already been shown to be correlated with the development of glucose abnormalities in pregnancy and now, in a new paper, progesterone receptor-knockout mice are found to have improved glucose tolerance. Glucose 101-108 progesterone receptor Mus musculus 161-182 11977981-6 2002 Lower induction of Ihh, Ptc, and Hoxa10 is seen in response to progesterone in the uteri of Pgr(-/-) mutant mice lacking progesterone nuclear steroid receptor. Progesterone 63-75 progesterone receptor Mus musculus 92-95 12406547-0 2002 Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. 7,12-dimethylbenz 83-100 progesterone receptor Mus musculus 12-33 12406547-0 2002 Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. 7,12-dimethylbenz 83-100 progesterone receptor Mus musculus 35-37 12406547-0 2002 Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. anthracene 103-113 progesterone receptor Mus musculus 12-33 12406547-0 2002 Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. anthracene 103-113 progesterone receptor Mus musculus 35-37 12444077-1 2002 In mice deficient in progesterone receptor (PR), follicles of ovulatory size develop but fail to ovulate, providing evidence for an essential role for progesterone and PR in ovulation in mice. Progesterone 21-33 progesterone receptor Mus musculus 44-46 12444077-1 2002 In mice deficient in progesterone receptor (PR), follicles of ovulatory size develop but fail to ovulate, providing evidence for an essential role for progesterone and PR in ovulation in mice. Progesterone 21-33 progesterone receptor Mus musculus 168-170 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. Mifepristone 13-18 progesterone receptor Mus musculus 41-62 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. Mifepristone 13-18 progesterone receptor Mus musculus 64-66 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. Glucose 83-90 progesterone receptor Mus musculus 41-62 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. Glucose 83-90 progesterone receptor Mus musculus 64-66 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. dbdb 120-124 progesterone receptor Mus musculus 41-62 12438645-3 2002 In contrast, RU486, an antagonist of the progesterone receptor (PR), reduces blood glucose levels in both female WT and dbdb mice. dbdb 120-124 progesterone receptor Mus musculus 64-66 12438645-4 2002 Furthermore, female, but not male, PR-- mice had lower fasting glycemia than PR++ mice and showed higher insulin levels on glucose injection. Glucose 123-130 progesterone receptor Mus musculus 35-37 12297545-9 2002 The whole-uterus level of PR and Hoxa10 mRNAs did not vary; however, the PR protein was induced in the stroma 24 h after oil infusion. Oils 121-124 progesterone receptor Mus musculus 73-75 12117781-8 2002 These data show that multiple components of the cyclin D1/CDK4/p16(Ink4a)/pRb signaling pathway are frequently altered early in lung lesions of AJBL6 TGF-beta1 HT mice that are induced by ethyl carbamate as a function of progressive lung carcinogenesis, suggesting that components of this pathway may be potential targets for gene therapy. Urethane 188-203 progesterone receptor Mus musculus 74-77 11880592-11 2002 Genistein in the diet reduced the incidence of poorly differentiated prostatic adenocarcinomas in a dose-dependent manner and down-regulated androgen receptor, estrogen receptor-alpha, progesterone receptor, epidermal growth factor receptor, insulin-like growth factor-I, and extracellular signal-regulated kinase-1 but not estrogen receptor-beta and transforming growth factor-alpha mRNA expressions. Genistein 0-9 progesterone receptor Mus musculus 185-206 12043456-3 2002 MXT+ contains estrogen receptors (ER; 6.9 fmol/mg protein) as well as progesterone receptors (PgR; 9.2 fmol/mg protein) and therefore is inhibited by tamoxifen (Tam). Tamoxifen 150-159 progesterone receptor Mus musculus 70-92 12043456-3 2002 MXT+ contains estrogen receptors (ER; 6.9 fmol/mg protein) as well as progesterone receptors (PgR; 9.2 fmol/mg protein) and therefore is inhibited by tamoxifen (Tam). Tamoxifen 150-159 progesterone receptor Mus musculus 94-97 11313721-10 2001 Progesterone inhibited uterine epithelial apoptosis only in tissue recombinants prepared with PR-positive stroma. Progesterone 0-12 progesterone receptor Mus musculus 94-96 12017544-8 2002 For example, mice null for the LH-induced genes progesterone receptor (PR) and cyclo-oxygenase-2 (COX-2) fail to ovulate. Luteinizing Hormone 31-33 progesterone receptor Mus musculus 48-69 12017544-8 2002 For example, mice null for the LH-induced genes progesterone receptor (PR) and cyclo-oxygenase-2 (COX-2) fail to ovulate. Luteinizing Hormone 31-33 progesterone receptor Mus musculus 71-73 12017551-2 2002 Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. Progesterone 25-37 progesterone receptor Mus musculus 191-195 12017551-6 2002 First, analysis of the structural and functional relationships of each isoform using in vitro systems has generated compelling evidence to support the conclusion that PR-A and PR-B have different transcription activation properties when liganded to progesterone. Progesterone 249-261 progesterone receptor Mus musculus 176-180 12017551-8 2002 Selective ablation of PR-A and PR-B proteins in mice using these technologies has allowed us to address the spatiotemporal expression and contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone 227-239 progesterone receptor Mus musculus 31-35 12017551-9 2002 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are, indeed, reflected in an ability of the individual isoforms to elicit distinct, physiological responses to progesterone. Progesterone 339-351 progesterone receptor Mus musculus 177-181 12017551-12 2002 These tissue-selective activities of PR-B are due to this isoform"s ability to regulate a subset of progesterone-responsive target genes in reproductive tissues rather than to differences in its spatiotemporal expression relative to the PR-A isoform. Progesterone 100-112 progesterone receptor Mus musculus 37-41 11448926-6 2001 Consistent with these findings, in vivo administration of the geldanamycin derivative 17-allylaminogeldanamycin (17AAG; NSC330507) to estrogen-supplemented, tumor-bearing SCID mice resulted in marked depletion of progesterone receptor levels in both uterus and tumor. geldanamycin 62-74 progesterone receptor Mus musculus 213-234 11448926-6 2001 Consistent with these findings, in vivo administration of the geldanamycin derivative 17-allylaminogeldanamycin (17AAG; NSC330507) to estrogen-supplemented, tumor-bearing SCID mice resulted in marked depletion of progesterone receptor levels in both uterus and tumor. tanespimycin 86-111 progesterone receptor Mus musculus 213-234 11448926-6 2001 Consistent with these findings, in vivo administration of the geldanamycin derivative 17-allylaminogeldanamycin (17AAG; NSC330507) to estrogen-supplemented, tumor-bearing SCID mice resulted in marked depletion of progesterone receptor levels in both uterus and tumor. tanespimycin 113-118 progesterone receptor Mus musculus 213-234 11518735-8 2001 Furthermore, reintroduction of PR into PRKO-derived VSMCs using adenoviral methods restored progesterone-mediated inhibition of proliferation to these cells. Progesterone 92-104 progesterone receptor Mus musculus 31-33 11518735-9 2001 This effect was reversed by the PR antagonist, RU 486. Mifepristone 47-53 progesterone receptor Mus musculus 32-34 11431142-10 2001 Although E(2) supplementation did not cause suppression of the elevated expression of p53 and Bax mRNAs, it caused marked enhancement of expression levels of lactoferrin and progesterone receptor mRNAs in the uteri as well as increases in uterine wet weight. Estradiol 9-13 progesterone receptor Mus musculus 174-195 9560231-1 1998 Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. Progesterone 19-31 progesterone receptor Mus musculus 42-44 11397560-11 2001 resulted in a decrease in the E(2)-induced upregulation of uterine and hepatic nuclear PR (uterine PR values of 39.7+/-6.6 and 23.7+/-3.4 fmol/mg for E(2)+vehicle and E(2)+acetaminophen, respectively, P<0.05). Acetaminophen 172-185 progesterone receptor Mus musculus 87-89 11150243-6 2001 This response to DES involved multilayering of basal epithelial cells, expression of cytokeratin 10, and up-regulation of the progesterone receptor. Diethylstilbestrol 17-20 progesterone receptor Mus musculus 126-147 11133684-2 2001 17 beta-Estradiol (E(2)) increased PR levels in uterine stroma of ovariectomized alphaERKO mice, and ICI 182 780 (ICI) inhibited this E(2)-induced PR expression. Estradiol 3-17 progesterone receptor Mus musculus 35-37 11133684-2 2001 17 beta-Estradiol (E(2)) increased PR levels in uterine stroma of ovariectomized alphaERKO mice, and ICI 182 780 (ICI) inhibited this E(2)-induced PR expression. Estradiol 3-17 progesterone receptor Mus musculus 147-149 11133684-4 2001 In organ cultures of alphaERKO uterus, both E(2) and diethylstilbestrol induced stromal PR, and ICI inhibited this induction. Estradiol 44-48 progesterone receptor Mus musculus 88-90 11133684-4 2001 In organ cultures of alphaERKO uterus, both E(2) and diethylstilbestrol induced stromal PR, and ICI inhibited this induction. Diethylstilbestrol 53-71 progesterone receptor Mus musculus 88-90 11133684-9 2001 This study suggests that up-regulation of PR in endometrial stroma is mediated through at least three mechanisms: 1) classical estrogen signaling through ERalpha, 2) estrogen signaling through ERbeta, and 3) as a result of mechanical stimulation plus progesterone, which induces stromal cells to differentiate into decidual cells. Progesterone 251-263 progesterone receptor Mus musculus 42-44 11145618-7 2001 Estradiol treatment increased progesterone receptor immunoreactive (PR-ir) cell number in WT female VMN and POA, but no change was noted in brains of WT castrates. Estradiol 0-9 progesterone receptor Mus musculus 30-51 10976068-3 2000 By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Progesterone 117-129 progesterone receptor Mus musculus 56-60 10976068-3 2000 By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Progesterone 159-171 progesterone receptor Mus musculus 56-60 14973394-4 2000 Use of these mice in combination with mammary gland transplantation indicates that developmental regulation by progesterone appears to occur through a paracrine mechanism in which progesterone receptor (PR) positive cells represent a subset of non-proliferating epithelial cells that are capable of directing proliferation and/or differentiation of neighboring receptor negative cells. Progesterone 111-123 progesterone receptor Mus musculus 180-201 14973394-4 2000 Use of these mice in combination with mammary gland transplantation indicates that developmental regulation by progesterone appears to occur through a paracrine mechanism in which progesterone receptor (PR) positive cells represent a subset of non-proliferating epithelial cells that are capable of directing proliferation and/or differentiation of neighboring receptor negative cells. Progesterone 111-123 progesterone receptor Mus musculus 203-205 10781075-7 2000 Cathepsin L is induced in granulosa cells of growing follicles by follicle-stimulating hormone, but the highest levels of cathepsin L mRNA occur in preovulatory follicles in response to LH in a PR-dependent manner. Luteinizing Hormone 186-188 progesterone receptor Mus musculus 194-196 10727249-1 2000 Regulation of progesterone receptor (PR) by estradiol-17beta (E(2)) in mouse uterine and vaginal epithelia was studied. Estradiol 44-60 progesterone receptor Mus musculus 14-35 10727249-1 2000 Regulation of progesterone receptor (PR) by estradiol-17beta (E(2)) in mouse uterine and vaginal epithelia was studied. Estradiol 44-60 progesterone receptor Mus musculus 37-39 10727249-7 2000 Hence, in vagina, E(2) induces PR directly via ERalpha within the tissue. Estradiol 18-22 progesterone receptor Mus musculus 31-33 10727250-1 2000 The objective of this study was to determine whether uterine stromal and/or epithelial progesterone receptor (PR) is required for the antagonism by progesterone (P(4)) of estradiol-17beta (E(2)) action on expression of PR and lactoferrin in uterine epithelium. Progesterone 87-99 progesterone receptor Mus musculus 110-112 10727250-1 2000 The objective of this study was to determine whether uterine stromal and/or epithelial progesterone receptor (PR) is required for the antagonism by progesterone (P(4)) of estradiol-17beta (E(2)) action on expression of PR and lactoferrin in uterine epithelium. Estradiol 171-187 progesterone receptor Mus musculus 87-108 10727250-1 2000 The objective of this study was to determine whether uterine stromal and/or epithelial progesterone receptor (PR) is required for the antagonism by progesterone (P(4)) of estradiol-17beta (E(2)) action on expression of PR and lactoferrin in uterine epithelium. Estradiol 171-187 progesterone receptor Mus musculus 110-112 10707954-6 2000 The overexpression and disrupted cellular distribution of PR in C/EBPbeta-/- mice were coincident with a striking 10-fold decrease in cell proliferation after acute steroid hormone treatment, assayed by incorporation of bromodeoxyuridine. Steroids 165-180 progesterone receptor Mus musculus 58-60 10707954-6 2000 The overexpression and disrupted cellular distribution of PR in C/EBPbeta-/- mice were coincident with a striking 10-fold decrease in cell proliferation after acute steroid hormone treatment, assayed by incorporation of bromodeoxyuridine. Bromodeoxyuridine 220-237 progesterone receptor Mus musculus 58-60 9878278-5 1998 In a second experiment, we tested whether male mice heterozygous for a null mutation at the progesterone receptor locus were responsive to testosterone and progesterone treatment. Testosterone 139-151 progesterone receptor Mus musculus 92-113 9630742-5 1998 This activation is blocked by the progesterone receptor antagonist RU486 and is independent of new protein synthesis. Mifepristone 67-72 progesterone receptor Mus musculus 34-55 11196177-1 2001 We have developed an experimental model of mammary carcinogenesis in which the administration of medroxyprogesterone acetate (MPA) to female BALB/c mice induces progestin-dependent ductal metastatic mammary tumors with high levels of estrogen receptor (ER) and progesterone receptor (PR). Medroxyprogesterone Acetate 97-124 progesterone receptor Mus musculus 261-282 11196177-1 2001 We have developed an experimental model of mammary carcinogenesis in which the administration of medroxyprogesterone acetate (MPA) to female BALB/c mice induces progestin-dependent ductal metastatic mammary tumors with high levels of estrogen receptor (ER) and progesterone receptor (PR). Medroxyprogesterone Acetate 97-124 progesterone receptor Mus musculus 284-286 9607801-0 1998 Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen. catechol 127-135 progesterone receptor Mus musculus 58-79 9607801-13 1998 Similar to E2, Kepone increased the expression of PR mRNA in both uterine epithelium and stroma. Chlordecone 15-21 progesterone receptor Mus musculus 50-52 9560231-1 1998 Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. Progesterone 19-31 progesterone receptor Mus musculus 56-58 9497105-5 1998 MG1361 cells were positive for specific ER and PgR binding which was competed by tamoxifen, making this cell line useful for the evaluation of endocrine therapy. Tamoxifen 81-90 progesterone receptor Mus musculus 47-50 9484792-5 1998 Tam + MPA association produced the same results as Tam alone for ER and PgR nuclear retention, but receptor content was not significantly different from that of controls. tam + mpa 0-9 progesterone receptor Mus musculus 72-75 9484792-5 1998 Tam + MPA association produced the same results as Tam alone for ER and PgR nuclear retention, but receptor content was not significantly different from that of controls. Tamoxifen 0-3 progesterone receptor Mus musculus 72-75 9484792-8 1998 When Tam and 8Cl were administered together, 8Cl counteracted the effect of Tam only on PgR content. Tamoxifen 5-8 progesterone receptor Mus musculus 88-91 9484792-8 1998 When Tam and 8Cl were administered together, 8Cl counteracted the effect of Tam only on PgR content. 8cl 45-48 progesterone receptor Mus musculus 88-91 9484792-8 1998 When Tam and 8Cl were administered together, 8Cl counteracted the effect of Tam only on PgR content. Tamoxifen 76-79 progesterone receptor Mus musculus 88-91 9484792-9 1998 When associated with MPA, 8Cl changed the effects of MPA on ER and PgR nuclear retention, whereas on receptor content, only that of ER was increased (502+/-47 vs 328+/-20 fmol/mg protein in controls). 8cl 26-29 progesterone receptor Mus musculus 67-70 9221830-6 1997 Several hydroxy-PCB congeners exhibited antiestrogenic activity (primarily in the mouse uterus) and two compounds, 2,2",3",5",6- and 2,2",3",4",6"-pentachloro-4-biphenylol, inhibited E2-induced uterine wet weight, PR binding, and peroxidase activity in the mouse uterus. 2,2",3",4",6"-pentachloro-4-biphenylol 133-171 progesterone receptor Mus musculus 214-216 9435255-5 1998 Because progesterone is a mitogenic hormone in mammary glands and PR is required for mammary development, these data provide direct evidence that in vivo a regulated expression of the two isoforms of PR is critical for appropriate cellular response to progesterone and that for mammary glands this may have major implications to carcinogenesis. Progesterone 8-20 progesterone receptor Mus musculus 200-202 8961281-0 1996 Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice. Dopamine 0-8 progesterone receptor Mus musculus 33-54 8961281-1 1996 Using the recently generated mutant mice strain (PRKO) carrying a null mutation for the progesterone receptor (PR) gene by gene targeting, we examined the critical role of PR as a coordinator of key regulatory events involved in the steroid hormone and dopamine-facilitated sexual behavior in female mice. Dopamine 253-261 progesterone receptor Mus musculus 88-109 8961281-2 1996 In vitro one-point binding analyses of estradiol benzoate (EB)-induced cellular PRs and immunohistochemistry of PR in the mediobasal hypothalamus demonstrated a reduction in binding in the homozygous females, equivalent to background levels seen in EB-unresponsive tissue. estradiol 3-benzoate 39-57 progesterone receptor Mus musculus 80-82 8961281-2 1996 In vitro one-point binding analyses of estradiol benzoate (EB)-induced cellular PRs and immunohistochemistry of PR in the mediobasal hypothalamus demonstrated a reduction in binding in the homozygous females, equivalent to background levels seen in EB-unresponsive tissue. estradiol 3-benzoate 59-61 progesterone receptor Mus musculus 80-82 8961281-8 1996 We conclude that multiple signal transduction pathways coexist in the neuroendocrine system for reproductive behavior, with PR acting as a transcriptional mediator for dopamine, as well as progesterone, to achieve integration of neural communication in the central nervous system. Dopamine 168-176 progesterone receptor Mus musculus 124-126 8961281-8 1996 We conclude that multiple signal transduction pathways coexist in the neuroendocrine system for reproductive behavior, with PR acting as a transcriptional mediator for dopamine, as well as progesterone, to achieve integration of neural communication in the central nervous system. Progesterone 189-201 progesterone receptor Mus musculus 124-126 8902208-1 1996 We hypothesized that treatment of pregnant mice with the progesterone receptor antagonist RU486 might cause preterm labor and result in the delivery of live pups. Mifepristone 90-95 progesterone receptor Mus musculus 57-78 33588025-5 2021 Quantitative real-time PCR analysis revealed significantly increased expression of Cyclin d1, Esr1, Igf1, Igfbp2, Vegf, Oct4, and Pgr after estradiol and leptin co-treatment. Estradiol 140-149 progesterone receptor Mus musculus 130-133 7583777-2 1995 CsA alone, at 5-10 microM concentrations, induced almost complete nuclear transfer of the PR-mutant within 18 h. In contrast, FK506 and Rapa at the same concentrations had no effect. Cyclosporine 0-3 progesterone receptor Mus musculus 90-92 8166457-3 1994 On the other hand, Progesterone receptor (PR) level in normal glands tended to be lower in group MC than in group FC, which was recovered by chronic treatment with oestradiol benzoate (group OB). Methylcholanthrene 97-99 progesterone receptor Mus musculus 19-40 8166457-3 1994 On the other hand, Progesterone receptor (PR) level in normal glands tended to be lower in group MC than in group FC, which was recovered by chronic treatment with oestradiol benzoate (group OB). Methylcholanthrene 97-99 progesterone receptor Mus musculus 42-44 8166457-3 1994 On the other hand, Progesterone receptor (PR) level in normal glands tended to be lower in group MC than in group FC, which was recovered by chronic treatment with oestradiol benzoate (group OB). estradiol 3-benzoate 164-183 progesterone receptor Mus musculus 19-40 8166457-3 1994 On the other hand, Progesterone receptor (PR) level in normal glands tended to be lower in group MC than in group FC, which was recovered by chronic treatment with oestradiol benzoate (group OB). estradiol 3-benzoate 164-183 progesterone receptor Mus musculus 42-44 8339385-8 1993 Toremifene blocked the estradiol-induced increase in progesterone receptor levels in a dose-dependent fashion. Toremifene 0-10 progesterone receptor Mus musculus 53-74 8339385-8 1993 Toremifene blocked the estradiol-induced increase in progesterone receptor levels in a dose-dependent fashion. Estradiol 23-32 progesterone receptor Mus musculus 53-74 1375575-9 1992 The PgR-EIA values under low-salt conditions increased 10-fold within 12 hr, indicating an intact receptor mechanism. Salts 29-33 progesterone receptor Mus musculus 4-7 2069958-6 1991 The murine progesterone receptor had complete identity for the DNA binding domain of human and rabbit progesterone receptors and 99% homology with the chicken progesterone receptor; for the steroid binding domain, it had 96% homology with human and rabbit progesterone receptors and 86% homology with chicken progesterone receptors. Steroids 190-197 progesterone receptor Mus musculus 11-32 8603049-3 1996 In most tissues studied, the PR is induced by ovarian estrogen via the estrogen receptor (ER), thereby implying that many of the observed reproductive physiological responses attributed to PR could conceivably be due to the combined effects of progesterone and estrogen. Progesterone 244-256 progesterone receptor Mus musculus 29-31 7557380-2 1995 The physiological effects of progesterone are mediated by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors. Progesterone 29-41 progesterone receptor Mus musculus 62-83 7557380-2 1995 The physiological effects of progesterone are mediated by the progesterone receptor (PR), a member of the nuclear receptor superfamily of transcription factors. Progesterone 29-41 progesterone receptor Mus musculus 85-87 7557380-3 1995 In most cases the PR is induced by estrogen, implying that many of the in vivo effects attributed to progesterone could also be the result of concomitantly administered estrogen. Progesterone 101-113 progesterone receptor Mus musculus 18-20 7583777-0 1995 Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. Cyclosporine 0-13 progesterone receptor Mus musculus 57-78 34101200-8 2021 Notably, serum oestrogen and progesterone levels were significantly increased, whereas the expression of uterine oestrogen receptor and progesterone receptor was decreased following 1600 mg/kg EtP or 2500 mg/kg PrP exposure. ethyl-p-hydroxybenzoate 193-196 progesterone receptor Mus musculus 136-157 33808965-6 2021 Improved systemic and ovarian immune functions, endometrial progesterone receptor and coreceptor expressions and uterine vascular adaptation to pregnancy were among features of enhanced progesterone-receptor sensitivity in the low-dose tacrolimus-treated mouse model of the disease. Tacrolimus 236-246 progesterone receptor Mus musculus 60-81 34935393-10 2022 In summary, baicalein functioned as a PR antagonist in vivo and therefore may oppose P4 action under certain conditions such as uterine hyperplasia, fibroids, and uterine cancers. baicalein 12-21 progesterone receptor Mus musculus 38-40 34748236-2 2021 In prenatally androgenised (PNA) mice, a model of PCOS, progesterone receptor (PR) protein expression is reduced in arcuate nucleus (ARC) GABA neurons. gamma-Aminobutyric Acid 138-142 progesterone receptor Mus musculus 56-77 34774516-3 2022 As MPA interacts most strongly with progesterone receptor (PR), we reasoned that PR would contribute to MPA-induced regression of cervical cancer. Medroxyprogesterone Acetate 3-6 progesterone receptor Mus musculus 36-57 34774516-3 2022 As MPA interacts most strongly with progesterone receptor (PR), we reasoned that PR would contribute to MPA-induced regression of cervical cancer. Medroxyprogesterone Acetate 104-107 progesterone receptor Mus musculus 36-57 34774516-5 2022 In the present study, we found that the deletion of Pgr in the cervical cancer cells ablated the MPA"s therapeutic effect in the HPV transgenic mouse model. Medroxyprogesterone Acetate 97-100 progesterone receptor Mus musculus 52-55 34986559-8 2022 Transcriptomic analysis of the endometrium revealed that C3G intake had anti-estrogenic effects, attenuating Cd-induced endometrial epithelial cell proliferation by inhibiting estrogen-responsive genes, enhancing epithelial progesterone receptor expression, and regulating Klf4 expression. Cadmium 109-111 progesterone receptor Mus musculus 224-245 34156060-7 2021 Medroxyprogesterone acetate, a PR-activating drug, regresses cervical cancer in the mouse model. Medroxyprogesterone Acetate 0-27 progesterone receptor Mus musculus 31-33 34101200-8 2021 Notably, serum oestrogen and progesterone levels were significantly increased, whereas the expression of uterine oestrogen receptor and progesterone receptor was decreased following 1600 mg/kg EtP or 2500 mg/kg PrP exposure. propylparaben 211-214 progesterone receptor Mus musculus 136-157 34572430-10 2021 Our study suggests that NSC139021 may be a potential chemotherapy drug for the treatment of glioblastoma by targeting the Skp2-p27/p21-Cyclin E/CDK2-pRb signaling pathway. 1-(2-thiazolylazo)-2-naphthol 24-33 progesterone receptor Mus musculus 149-152 34379733-5 2021 Using transgenic mice lacking PGR exclusively in kisspeptin cells (termed KissPRKOs), we previously demonstrated that progesterone action specifically in kisspeptin cells is essential for ovulation and normal fertility. Progesterone 118-130 progesterone receptor Mus musculus 30-33 34379733-9 2021 We found that targeted upregulation of PGR in kisspeptin neurons exclusively in the AVPV is sufficient to restore proper E2-induced LH surges in KissPRKO females, suggesting that this specific kisspeptin population is a key target of the necessary progesterone action for the surge. Estradiol 121-123 progesterone receptor Mus musculus 39-42 34379733-9 2021 We found that targeted upregulation of PGR in kisspeptin neurons exclusively in the AVPV is sufficient to restore proper E2-induced LH surges in KissPRKO females, suggesting that this specific kisspeptin population is a key target of the necessary progesterone action for the surge. Progesterone 248-260 progesterone receptor Mus musculus 39-42 35468896-4 2022 Mechanistically, stimulation of PGR by progesterone activates the tyrosine kinase SRC, which phosphorylates the transcriptional factor IRF3 at Y107, leading to its activation and induction of antiviral genes. Progesterone 39-51 progesterone receptor Mus musculus 32-35 34502315-11 2021 Moreover, CD73 expression was increased when estrogen and progesterone were co-administered and was inhibited by the pretreatment of the progesterone receptor antagonist RU486. Progesterone 58-70 progesterone receptor Mus musculus 137-158 34502315-11 2021 Moreover, CD73 expression was increased when estrogen and progesterone were co-administered and was inhibited by the pretreatment of the progesterone receptor antagonist RU486. Mifepristone 170-175 progesterone receptor Mus musculus 137-158 34344445-0 2021 Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland. Progesterone 93-105 progesterone receptor Mus musculus 0-21 34344445-18 2021 CONCLUSIONS: PR inhibition reverses known tumorigenic pathways in the mammary gland and suppresses a previously unknown effect of progesterone on RNA splicing events. Progesterone 130-142 progesterone receptor Mus musculus 13-15 35508278-4 2022 In the present study, we provide evidence for the insulin-sensitizing role of smoothelin-like protein 1 (SMTNL1) that is a ligand-dependent co-regulator of steroid receptors, predominantly the progesterone receptor. Steroids 156-163 progesterone receptor Mus musculus 193-214 35430461-5 2022 In addition, inhibiting IL-27 signaling with IL-27 neutralization antibody (anti-IL-27) suppressed the expression of decidualization-related molecules, receptors of estrogen (gene coded by ESR) and progesterone (PGR) induced by cAMP or estrogen plus progesterone. Progesterone 198-210 progesterone receptor Mus musculus 212-215 35430461-5 2022 In addition, inhibiting IL-27 signaling with IL-27 neutralization antibody (anti-IL-27) suppressed the expression of decidualization-related molecules, receptors of estrogen (gene coded by ESR) and progesterone (PGR) induced by cAMP or estrogen plus progesterone. Cyclic AMP 228-232 progesterone receptor Mus musculus 212-215 35430461-5 2022 In addition, inhibiting IL-27 signaling with IL-27 neutralization antibody (anti-IL-27) suppressed the expression of decidualization-related molecules, receptors of estrogen (gene coded by ESR) and progesterone (PGR) induced by cAMP or estrogen plus progesterone. Progesterone 250-262 progesterone receptor Mus musculus 212-215 35352576-9 2022 Bortezomib treatment may adversely affect ovarian function by accelerating ovarian reserve depletion and changing ERalpha and PR hormone levels that can cause fertility problems in the long term. Bortezomib 0-10 progesterone receptor Mus musculus 126-128 35498436-3 2022 Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Progesterone 56-68 progesterone receptor Mus musculus 27-48 35498436-3 2022 Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Progesterone 56-68 progesterone receptor Mus musculus 50-53 2626038-1 1989 The antiprogesterones Onapristone, ZK 112.993 (Schering AG), and Mifepristone (Roussel-Uclaf) proved to possess progesterone receptor-mediated antiproliferative effects in experimental mammary carcinomas. onapristone 22-33 progesterone receptor Mus musculus 112-133 35134138-8 2022 Interestingly, progesterone receptor knockout mice, which lack progesterone signaling, also have defects in post-pubertal uterine gland development. Progesterone 63-75 progesterone receptor Mus musculus 15-36 2626038-1 1989 The antiprogesterones Onapristone, ZK 112.993 (Schering AG), and Mifepristone (Roussel-Uclaf) proved to possess progesterone receptor-mediated antiproliferative effects in experimental mammary carcinomas. Mifepristone 65-77 progesterone receptor Mus musculus 112-133 3398533-4 1988 In the case of the adult gland, the mitogenic effects of progesterone appear to be related to the presence of E-dependent progesterone receptors (PgR). Progesterone 57-69 progesterone receptor Mus musculus 146-149 3191486-7 1988 Estradiol treatment of athymic mice also significantly increased cytosol progesterone receptor content in UISO-MEL-2 and UISO-MEL-4 xenografts. Estradiol 0-9 progesterone receptor Mus musculus 73-94 3402385-6 1988 Treatment of epithelial and stromal cells for 4 days with 10 nM estradiol led to a 2- to 6-fold increase in progesterone receptor concentration. Estradiol 64-73 progesterone receptor Mus musculus 108-129 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. tam-a 42-47 progesterone receptor Mus musculus 28-30 3282125-3 1988 Of the six anti-PgR antibodies tested, one (alpha PR6) precipitates murine PgR in an assay using protein A-sepharose as an absorbent for the antibody. Sepharose 107-116 progesterone receptor Mus musculus 16-19 3282125-3 1988 Of the six anti-PgR antibodies tested, one (alpha PR6) precipitates murine PgR in an assay using protein A-sepharose as an absorbent for the antibody. Sepharose 107-116 progesterone receptor Mus musculus 75-78 3338079-8 1988 Progesterone receptor levels were higher in estradiol (376 +/- 35 fmol/mg cytosol protein)- or TAM (317 +/- 37 fmol/mg cytosol protein)-stimulated EnCa101 tumors than control (42 +/- 5 fmol/mg cytosol protein) and increased further with combined treatment (485 +/- 75 fmol/mg cytosol protein). Tamoxifen 95-98 progesterone receptor Mus musculus 0-21 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. tam-a 42-47 progesterone receptor Mus musculus 123-125 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. Tamoxifen 42-45 progesterone receptor Mus musculus 28-30 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. Tamoxifen 42-45 progesterone receptor Mus musculus 123-125 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. Tamoxifen 58-61 progesterone receptor Mus musculus 28-30 3429992-8 1987 The significant increase in PR content in TAM-A following TAM administration obviously indicated a so-called TAM-dependent PR induction effect. Tamoxifen 58-61 progesterone receptor Mus musculus 123-125 4066677-10 1985 Uterine progesterone receptor was induced to varying degrees by all compounds; the indenestrol isomers (IA and IB) were the most active. indenestrol 83-94 progesterone receptor Mus musculus 8-29 3595517-13 1987 The suppression of nuclear ER by CB-154 is reflected in a loss of estrogen-induced progesterone receptor activity. Bromocriptine 33-39 progesterone receptor Mus musculus 83-104 3595517-14 1987 The ability of tamoxifen to inhibit estrogen-stimulated progesterone receptor activity is appreciably curtailed by concomitant treatment with PRL. Tamoxifen 15-24 progesterone receptor Mus musculus 56-77 6744316-6 1984 The PR concentration in these tumors was elevated in response to TAM treatment. Tamoxifen 65-68 progesterone receptor Mus musculus 4-6 6744316-7 1984 That the TAM-induced PR was indeed functional was evident from (a) increased activities of the progestin-sensitive enzyme, 17 beta-estradiol hydroxysteroid dehydrogenase and (b) histological appearance of subnuclear vacuolization in these tumors after progestin administration. Tamoxifen 9-12 progesterone receptor Mus musculus 21-23 6744316-9 1984 Based on the finding that TAM induces functional PR, we predict that steroid receptor-positive endometrial carcinoma may show a greater response rate to combined, long-term treatment with TAM and progestin. Tamoxifen 26-29 progesterone receptor Mus musculus 49-51 6744316-9 1984 Based on the finding that TAM induces functional PR, we predict that steroid receptor-positive endometrial carcinoma may show a greater response rate to combined, long-term treatment with TAM and progestin. Tamoxifen 188-191 progesterone receptor Mus musculus 49-51 4039248-10 1985 When 17 beta-estradiol was added to the culture medium, a significant (P less than 0.01) increase in PgR concentration was observed in mixed cultures. Estradiol 5-22 progesterone receptor Mus musculus 101-104 6542571-7 1984 Estradiol administration also enhances the level of progesterone receptor in mouse breast. Estradiol 0-9 progesterone receptor Mus musculus 52-73 6542571-9 1984 Dihydrotestosterone does not compete for binding to the progesterone receptor, but it does inhibit estrogen-mediated increases of progesterone receptor content of breast tissue cytosol from both control mice and mice with X-linked testicular feminization (tfm)/Y. Dihydrotestosterone 0-19 progesterone receptor Mus musculus 130-151 6316005-6 1983 Although cytosol estrogen receptors (ERc), nuclear estrogen receptors (ERn), and progesterone receptors (PgR) were detected by dextran coated-charcoal method and exchange assay in the growing tumors, ERn and PgR of regressing tumors was usually negative. Dextrans 127-134 progesterone receptor Mus musculus 105-108