PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2497197-0 1989 Recombinant bovine interferon-gamma as an immunomodulator in dexamethasone-treated and nontreated cattle. Dexamethasone 61-74 interferon gamma Bos taurus 19-35 2478645-0 1989 Role for arachidonic acid metabolism and protein synthesis in recombinant bovine interferon-gamma-induced activation of bovine neutrophils. Arachidonic Acid 9-25 interferon gamma Bos taurus 81-97 2504679-2 1989 In this paper we have assessed the effects of acetylsalicylic acid (aspirin), thymosin alpha and thymosin fraction 5 (TF5), a partially purified calf thymic preparation, on production of IFN-gamma in vitro. Aspirin 46-66 interferon gamma Bos taurus 187-196 2504679-2 1989 In this paper we have assessed the effects of acetylsalicylic acid (aspirin), thymosin alpha and thymosin fraction 5 (TF5), a partially purified calf thymic preparation, on production of IFN-gamma in vitro. Aspirin 68-75 interferon gamma Bos taurus 187-196 2539694-2 1989 Activation of neutrophils in vitro with interferon-gamma resulted in enhanced production of O2- and myelopeoroxidase-H2O2-halide activity by neutrophils in the presence of B. abortus. Oxygen 92-94 interferon gamma Bos taurus 40-56 2539694-2 1989 Activation of neutrophils in vitro with interferon-gamma resulted in enhanced production of O2- and myelopeoroxidase-H2O2-halide activity by neutrophils in the presence of B. abortus. Hydrogen Peroxide 117-121 interferon gamma Bos taurus 40-56 2539694-2 1989 Activation of neutrophils in vitro with interferon-gamma resulted in enhanced production of O2- and myelopeoroxidase-H2O2-halide activity by neutrophils in the presence of B. abortus. halide 122-128 interferon gamma Bos taurus 40-56 32572800-7 2021 The calves treated with BUPA + ITMs revealed significant (P <= 0.041) elevation in the circulating interferon-gamma (IFN-gamma) and significant (P <= 0.011) reduction in the interleukin-10 (IL-10) levels. bupa 24-28 interferon gamma Bos taurus 99-115 3102381-7 1987 Treatment of ConAS with glycine-hydrochloride buffer (pH 2) resulted in a total loss of antiviral activity mediated by gamma interferon (IFN-gamma). Glycine 24-45 interferon gamma Bos taurus 137-146 33857743-6 2021 Further analyses focusing on PGA1 revealed that treatment with PGA1 in the presence of concanavalin A (con A) downregulated CD69, an activation marker, and IFN-gamma expression in both CD4+ and CD8+ T cells. prostaglandin A1 63-67 interferon gamma Bos taurus 156-165 33857743-7 2021 Sorted CD3+ T cells stimulated with con A were cultivated with PGA1, and IFN-gamma and TNF-alpha concentrations decreased upon PGA1 treatment. prostaglandin A1 127-131 interferon gamma Bos taurus 73-82 32572800-7 2021 The calves treated with BUPA + ITMs revealed significant (P <= 0.041) elevation in the circulating interferon-gamma (IFN-gamma) and significant (P <= 0.011) reduction in the interleukin-10 (IL-10) levels. bupa 24-28 interferon gamma Bos taurus 117-126 32572800-8 2021 Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-alpha (P <= 0.0001) and IL-10 (P <= 0.012) contents, and significant elevation in IFN-gamma (P <= 0.0002) content on day 14 post-therapy. bupa 34-38 interferon gamma Bos taurus 172-181 32572800-8 2021 Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-alpha (P <= 0.0001) and IL-10 (P <= 0.012) contents, and significant elevation in IFN-gamma (P <= 0.0002) content on day 14 post-therapy. Oxygen 41-44 interferon gamma Bos taurus 172-181 33997349-9 2021 Additionally, GTP supplementation up-regulated concentrations of interleukin-6 and interleukin-10, but down-regulated concentrations of tumor necrosis factor-alpha, interleukin-1beta, interleukin-2, interleukin-8, and interferon-gamma in plasma. Guanosine Triphosphate 14-17 interferon gamma Bos taurus 218-234 32070525-2 2020 The results showed that RAMPtp significantly promoted the secretions of cytokines (IFN-gamma, IL-1alpha, IL-21, IFN-alpha, CCL4, CXCL9 and CXCL10), increased the proportions of CD4+ and CD8+ subpopulations, and enhanced the expressions of c-JUN, NFAT4, STAT1 and STAT3. ramptp 24-30 interferon gamma Bos taurus 83-92 32725514-0 2020 IFN-gamma Activates the TLR4-CCL5 Signaling Through Reducing Arginine Level, Leading to Enhanced Susceptibility of Bovine Mammary Epithelial Cells to Staphylococcus aureus. Arginine 61-69 interferon gamma Bos taurus 0-9 32649844-10 2020 Although CM-Ex stimulation alone did not induce interferon-gamma (IFN-gamma) production by NK cells or gammadeltaT cells, simultaneous stimulation with CM-Ex, IL-2 and IL-12 significantly enhanced IFN-gamma production. cm-ex 152-157 interferon gamma Bos taurus 197-206 33014886-3 2020 Here, we report that bovine bone marrow-derived macrophage (BMDM) pre-stimulated with interferon gamma (IFNgamma) restricts intracellular Toxoplasma growth independently of nitric oxide. Nitric Oxide 173-185 interferon gamma Bos taurus 104-112 32851000-8 2020 Moreover, in comparison with the non-adjuvanted iFMDV vaccine, iFMDV-ISPA elicited an increased specific T-cell response against the virus, including higher interferon gamma (IFNgamma)+/CD8+ lymphocyte production in cattle. ifmdv-ispa 63-73 interferon gamma Bos taurus 157-173 32851000-8 2020 Moreover, in comparison with the non-adjuvanted iFMDV vaccine, iFMDV-ISPA elicited an increased specific T-cell response against the virus, including higher interferon gamma (IFNgamma)+/CD8+ lymphocyte production in cattle. ifmdv-ispa 63-73 interferon gamma Bos taurus 175-183 32674253-9 2020 The administration of meloxicam one hour before disbudding significantly attenuated the upregulation of IL6, PGHS2, TAC1, NOS1, and CRH gene transcription post-disbudding, while it did not suppress the elevated transcription of acute and pro-inflammatory cytokines such as IL1beta, IFNgamma, IL8, and TNFalpha genes. Meloxicam 22-31 interferon gamma Bos taurus 282-290 30776689-7 2019 Although NONOate decreased cell viability, it prevented TNF + IFNG-stimulated CASP3 activity in cultured LECs. pelargonic acid 9-16 interferon gamma Bos taurus 62-66 31560476-7 2019 The results suggested that ketoprofen- treated cows had a significantly lower concentration of TNF-alpha, IL-1alpha, IFN-gamma, NEFA and BHBA in the first and second postpartum week compared to the control group. Ketoprofen 27-37 interferon gamma Bos taurus 117-126 31668440-10 2020 Zeolite treatment downregulated neutrophil gene expression of CXCR4 and S100A8 and tended to lower gene expression for other immune mediators (CXCR1, IFNG, S100A12, and S100A9) compared with the control. Zeolites 0-7 interferon gamma Bos taurus 150-154 30783921-5 2019 More importantly, the Zn-supplemented LF product with lower Zn-saturation at lower dose exerted slightly higher macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations, and were capable of enhancing the interleukin-2 (IL-2), IL-4, and interferon-gamma production in the splenocytes or the IL-1beta, IL-6, and tumor necrosis factor-alpha production in the macrophages significantly (P < 0.05). Zinc 22-24 interferon gamma Bos taurus 260-276 30827373-0 2019 Simultaneous measurement of antigen-induced CXCL10 and IFN-gamma enhances test sensitivity for bovine TB detection in cattle. Terbium 102-104 interferon gamma Bos taurus 55-64 30614229-0 2019 Interferon-gamma regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells. c-abl 57-62 interferon gamma Bos taurus 0-16 30594355-8 2019 Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status. Vitamin D 54-63 interferon gamma Bos taurus 135-139 30614229-7 2019 The HDAC2 inhibitor, valproate (VPA) and the c-Abl inhibitor, imatinib, lowered the expression level of cyclin D1/CDK4, and increased the expression level of p21, leading to an inhibitory effect on IFN-gamma-induced malignant cell growth. Valproic Acid 21-30 interferon gamma Bos taurus 198-207 30614229-7 2019 The HDAC2 inhibitor, valproate (VPA) and the c-Abl inhibitor, imatinib, lowered the expression level of cyclin D1/CDK4, and increased the expression level of p21, leading to an inhibitory effect on IFN-gamma-induced malignant cell growth. Valproic Acid 32-35 interferon gamma Bos taurus 198-207 30614229-7 2019 The HDAC2 inhibitor, valproate (VPA) and the c-Abl inhibitor, imatinib, lowered the expression level of cyclin D1/CDK4, and increased the expression level of p21, leading to an inhibitory effect on IFN-gamma-induced malignant cell growth. Imatinib Mesylate 62-70 interferon gamma Bos taurus 198-207 29383579-2 2018 Results showed that medium supplemented with 0.50 mg/L of selenium significantly (P < 0.05) promoted cell viability, upregulated toll-like receptor gene (TLR4), anti-inflammatory cytokines (IL-4, IL-10, TGFbeta1), and expressions of blood-testis barrier proteins, and modulated expressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IFN-gamma). Selenium 58-66 interferon gamma Bos taurus 345-354 27033904-6 2016 On the contrary, the blockade of either EP2 or EP4 receptors, but not EP1 or EP3 receptors, prevented the PGE2-induced reduction of percentage of IFN-gamma-producing WC1(+) T cells. Dinoprostone 106-110 interferon gamma Bos taurus 146-155 30078591-7 2018 There was a similar elevation in serum cholesterol at 9 wpi in cattle with histopathological gut lesions associated with disease or those with an early high IFN-gamma response. Cholesterol 39-50 interferon gamma Bos taurus 157-166 29746817-3 2018 Our previous study demonstrated that diet-derived IFN-gamma promoted the malignant transformation of primary bovine mammary epithelial cells by accelerating arginine depletion. Arginine 157-165 interferon gamma Bos taurus 50-59 27025389-7 2016 Furthermore, mechanistic analysis confirmed that IFN-gamma mediated autophagy by depleting arginine and inhibiting the general control nonderepressible-2 kinase (GCN2)/eukaryotic initiation factor 2alpha (eIF2alpha) signaling pathway in BMECs. Arginine 91-99 interferon gamma Bos taurus 49-58 27025389-8 2016 Then, it was found that arginine supplementation could attenuate IFN-gamma-induced autophagy and recover milk synthesis to some extent. Arginine 24-32 interferon gamma Bos taurus 65-74 27033904-0 2016 The influence of prostaglandin E2 on the production of IFN-gamma by bovine CD4(+), CD8(+) and WC1(+) T cells. Dinoprostone 17-33 interferon gamma Bos taurus 55-64 27033904-1 2016 The aim of these studies was to assess the influence of prostaglandin E2 (PGE2) on the production of interferon-gamma (IFN-gamma) by bovine CD4(+), CD8(+), and WC1(+) T cells and furthermore, should this effect exist, to identify the E-prostanoid (EP) receptor subtype(s) responsible for this influence. Dinoprostone 56-72 interferon gamma Bos taurus 101-117 27033904-1 2016 The aim of these studies was to assess the influence of prostaglandin E2 (PGE2) on the production of interferon-gamma (IFN-gamma) by bovine CD4(+), CD8(+), and WC1(+) T cells and furthermore, should this effect exist, to identify the E-prostanoid (EP) receptor subtype(s) responsible for this influence. Dinoprostone 56-72 interferon gamma Bos taurus 119-128 27033904-1 2016 The aim of these studies was to assess the influence of prostaglandin E2 (PGE2) on the production of interferon-gamma (IFN-gamma) by bovine CD4(+), CD8(+), and WC1(+) T cells and furthermore, should this effect exist, to identify the E-prostanoid (EP) receptor subtype(s) responsible for this influence. Dinoprostone 74-78 interferon gamma Bos taurus 101-117 27033904-1 2016 The aim of these studies was to assess the influence of prostaglandin E2 (PGE2) on the production of interferon-gamma (IFN-gamma) by bovine CD4(+), CD8(+), and WC1(+) T cells and furthermore, should this effect exist, to identify the E-prostanoid (EP) receptor subtype(s) responsible for this influence. Dinoprostone 74-78 interferon gamma Bos taurus 119-128 29109952-0 2017 Is TB Testing Associated With Increased Blood Interferon-Gamma Levels? Terbium 3-5 interferon gamma Bos taurus 46-62 28821047-6 2017 When SMLN lymphocytes were cultured with RAMPtp in vitro, increased [Ca2+]i, more cells in S and G2/M phases and upregulated IFN-gamma and IL-17A while downregulated IL-4 mRNA expressions as well as the binding between SMLN lymphocytes and RAMPtp were observed. ramptp 41-47 interferon gamma Bos taurus 125-134 27358463-6 2016 The IFN-gamma responses of the samples stored up to 6 days postcollection in the supplemented RPMI medium were similar to those observed in the samples processed within 8 h after sampling, indicating that lymphocyte vitality and response were preserved. rpmi medium 94-105 interferon gamma Bos taurus 4-13 27033904-2 2016 We here report that exposure of bovine peripheral blood mononuclear cells (PBMCs) to PGE2 significantly and dose-dependently decreased the percentage of IFN-gamma-producing CD4(+) and CD8(+) T cells. Dinoprostone 85-89 interferon gamma Bos taurus 153-162 27033904-7 2016 These findings indicate that the ability of PGE2 to impair IFN-gamma production by WC1(+) T cells is mediated via EP2 and EP4 receptors. Dinoprostone 44-48 interferon gamma Bos taurus 59-68 27033904-3 2016 It was also shown that PGE2 reduced IFN-gamma production by WC1(+) T cells, but this effect was not dose dependent. Dinoprostone 23-27 interferon gamma Bos taurus 36-45 27551491-0 2016 Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-gamma-induced malignant transformation of primary bovine mammary epithelial cells. Arginine 22-30 interferon gamma Bos taurus 95-111 27033904-4 2016 The impairment of IFN-gamma production should be recognized as an anti-inflammatory and immunosuppressive action, thus the obtained results confirm the paradoxical status of PGE2 as a proinflammatory factor with immunosuppressive activity. Dinoprostone 174-178 interferon gamma Bos taurus 18-27 27551491-5 2016 IFN-gamma levels were significantly increased in cattle that received normal long-term dietary corn straw (CS) roughage supplementation. Cesium 107-109 interferon gamma Bos taurus 0-9 27551491-8 2016 Furthermore, we found that IFN-gamma promoted arginine depletion, activated the general control nonderepressible-2 kinase (GCN2) signalling pathway and resulted in an increase in autophagic flux and the amount of autophagy in BMECs. Arginine 46-54 interferon gamma Bos taurus 27-36 27551491-9 2016 Overall, our findings are the first to demonstrate that arginine depletion and kinase GCN2 expression mediate IFN-gamma-induced autophagy that may promote malignant progression and that immunometabolism, autophagy and cancer are strongly correlated. Arginine 56-64 interferon gamma Bos taurus 110-119 26460162-6 2016 Notably, Ipis-1-Ig inhibited the cell proliferation and production of IFN-gamma in bovine PBMCs even when CD14(+) cells were depleted, suggesting that Ipis could directly interact with T cells and inhibit their functions. ipis 9-13 interferon gamma Bos taurus 70-79 25887271-2 2015 Oenothein B, a polyphenol isolated from Epilobium angustifolium and other plant sources, enhances IFNgamma production by both bovine and human NK cells and T cells, alone and in response to secondary stimulation by cytokines or tumor cells. oenothein B 0-11 interferon gamma Bos taurus 98-106 26607309-11 2015 Interestingly, CD4(+) and CD8(+) gamma interferon (IFN-gamma)(+) cell responses were detected at significantly higher levels in animals vaccinated with Adt.O1C.2B.RGD than in animals vaccinated with Ad5.O1C.2B. 1,4-androstadiene-3,17-dione 152-155 interferon gamma Bos taurus 26-60 26053064-10 2015 Similarly, r-TpUB05 highly stimulated bovine PMBCs from 8/12 (67%) of ITM-immunized cattle tested to produce IFN-gamma and proliferate (p< 0.029) as compared to the 04 naive cattle included as controls. r-tpub05 11-19 interferon gamma Bos taurus 109-118 26375594-8 2015 In vitro stimulation of peripheral blood lymphocytes with ovalbumin followed by stimulation with PMA/ionomycin allowed the identification by flow cytometry of CD4+ T cells producing either IL-17A, IFN-gamma, or both cytokines. Tetradecanoylphorbol Acetate 97-100 interferon gamma Bos taurus 197-206 26375594-8 2015 In vitro stimulation of peripheral blood lymphocytes with ovalbumin followed by stimulation with PMA/ionomycin allowed the identification by flow cytometry of CD4+ T cells producing either IL-17A, IFN-gamma, or both cytokines. Ionomycin 101-110 interferon gamma Bos taurus 197-206 25499010-3 2015 Of these molecules, one (AcPIM6) induced significant levels of gamma interferon (IFN-gamma) in bovine PBMCs. acpim6 25-31 interferon gamma Bos taurus 63-90 24456132-10 2014 Accordingly, IFN-gamma production could be linked to the transplacental migration of tachyzoites, which may cause a reduction in PAG levels. phenylacetylglycine 129-132 interferon gamma Bos taurus 13-22 25008904-3 2014 We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production are partially restored in cattle following clearance of persistent infection with tetracycline. Tetracycline 277-289 interferon gamma Bos taurus 111-138 24845976-7 2014 Moreover, PD-L2-Ig significantly enhanced IFN-gamma production from virus envelope peptides-stimulated PBMCs derived from bovine leukemia virus-infected cattle. Peptides 83-91 interferon gamma Bos taurus 42-51 23764468-5 2013 Results showed differential expression of HDAC6, HDAC7 and DNMT3A genes in response to LPS in cells from all animals, while TSA significantly inhibited pro-inflammatory cytokine (TNF, IL2 and IFNG) expression (P<0.05), presumably by histone acetylation. trichostatin A 124-127 interferon gamma Bos taurus 192-196 23890724-5 2013 However, Interferon gamma (IFN-gamma) primed bovine monocytes released significantly higher amounts of IL-1beta after stimulation with S100A8, S100A9, and co-stimulation with adenosine triphosphate (ATP). Adenosine Triphosphate 175-197 interferon gamma Bos taurus 9-25 23890724-5 2013 However, Interferon gamma (IFN-gamma) primed bovine monocytes released significantly higher amounts of IL-1beta after stimulation with S100A8, S100A9, and co-stimulation with adenosine triphosphate (ATP). Adenosine Triphosphate 175-197 interferon gamma Bos taurus 27-36 23890724-5 2013 However, Interferon gamma (IFN-gamma) primed bovine monocytes released significantly higher amounts of IL-1beta after stimulation with S100A8, S100A9, and co-stimulation with adenosine triphosphate (ATP). Adenosine Triphosphate 199-202 interferon gamma Bos taurus 9-25 23890724-5 2013 However, Interferon gamma (IFN-gamma) primed bovine monocytes released significantly higher amounts of IL-1beta after stimulation with S100A8, S100A9, and co-stimulation with adenosine triphosphate (ATP). Adenosine Triphosphate 199-202 interferon gamma Bos taurus 27-36 24319444-7 2013 Notably, in AL, but not blood, a similar amount of IFN-gamma(+) NK cells was observed when cells were stimulated with IL-12 alone. Aluminum 12-14 interferon gamma Bos taurus 51-60 24034934-8 2013 Addition of rIL-12 induced a significant additive effect leading to a maximum increase in responder frequency of Ag-specific T cell subsets or NKp46+ cells with a heavy bias toward IFN-gamma production by CD4 T cells. ril-12 12-18 interferon gamma Bos taurus 181-190 23856004-0 2013 Effects of lysophopatidic acid on tumor necrosis factor alpha and interferon gamma action in the bovine corpus luteum. lysophopatidic acid 11-30 interferon gamma Bos taurus 66-82 23814356-0 2013 Effects of parturition and dexamethasone on DNA methylation patterns of IFN-gamma and IL-4 promoters in CD4+ T-lymphocytes of Holstein dairy cows. Dexamethasone 27-40 interferon gamma Bos taurus 72-81 23369108-5 2013 DEX lowered the production of IFN-gamma by the analyzed cells and raised the percentage of IL-10-producing cells. Dexamethasone 0-3 interferon gamma Bos taurus 30-39 23266095-7 2013 Paradoxically, the percentage of cells producing IFN-gamma, a proinflammatory cytokine, increased in the presence of dexamethasone, whereas the count of cells secreting the key anti-inflammatory and immunosuppressive cytokine, i.e. IL-10, declined. Dexamethasone 117-130 interferon gamma Bos taurus 49-58 23266095-11 2013 In the presence of meloxicam, percentages of IFN-gamma(+)CD25(-)WC1(+) cells as well as cells producing IL-10 declined, an effect observed in all analyzed cell populations. Meloxicam 19-28 interferon gamma Bos taurus 45-54 23286953-6 2013 The obtained results indicate that induction of CD8(+) lymphocyte depletion and impairment of IFN-gamma production by these cells participate in the production of the anti-inflammatory and immunosuppressive effect of dexamethasone in cattle. Dexamethasone 217-230 interferon gamma Bos taurus 94-103 23351642-5 2013 Hydrocortisone suppressed mitogen-driven IFN-gamma production by PBMCs from all three species of animals, confirming that this agent mediates anti-inflammatory effects in large animals. Hydrocortisone 0-14 interferon gamma Bos taurus 41-50 23814356-7 2013 Dexamethasone treated cells acted in a manner consistent with the glucocorticoid"s immunosuppressive activity, which mimicked the change at the IFN-gamma promoter region observed during parturition. Dexamethasone 0-13 interferon gamma Bos taurus 144-153 21840139-8 2012 The secretion of interferon gamma (IFN-gamma) in ELISPOT after in vitro re-stimulation of PBMC of BTV-8 vaccinated animals with BTV was evaluated in the field for the first time. CHEMBL3972792 98-101 interferon gamma Bos taurus 17-44 23628659-6 2013 The higher dose of MEL was found to significantly increase the percentage of IFN-gamma+ cells among the CD25-CD4+ cells. Meloxicam 19-22 interferon gamma Bos taurus 77-86 22349593-6 2012 The results obtained from this study indicate that the involvement of CD4+ lymphocytes in producing the anti-inflammatory and immunosuppressive effect of dexamethasone in cattle results from the fact that the drug had a depressive effect on the production of IFN-gamma by CD25-CD4+ cells. Dexamethasone 154-167 interferon gamma Bos taurus 259-268 22286534-6 2012 Inoculation with LAM induced higher levels of lymphoproliferation and IFN-gamma production in response to ConA and OVA (P < 0.05). lipoarabinomannan 17-20 interferon gamma Bos taurus 70-79 22286534-8 2012 Interestingly, our results showed that the use of LAM in vaccine preparations improved specific cell immune response evaluated by lymphoproliferation and IFN-gamma production by at least 50 and 25%, respectively, in cattle without interfering with tuberculosis and paratuberculosis diagnosis. lipoarabinomannan 50-53 interferon gamma Bos taurus 154-163 22847916-7 2012 TNF and IFNG stimulated NOS activity (P < 0.05) and 1400W, a specific inhibitor of iNOS, reduced NO production stimulated by TNF and IFNG in LECs (P < 0.05). N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 55-60 interferon gamma Bos taurus 136-140 22641921-13 2012 IFN-gamma expression was increased 105 days pp in CLA group in splenocytes and PBMC. Linoleic Acids, Conjugated 50-53 interferon gamma Bos taurus 0-9 23226309-5 2012 We also demonstrate that oenothein B enhanced the production of interferon-gamma (IFNgamma) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. oenothein B 25-36 interferon gamma Bos taurus 64-80 23226309-5 2012 We also demonstrate that oenothein B enhanced the production of interferon-gamma (IFNgamma) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. oenothein B 25-36 interferon gamma Bos taurus 82-90 21436614-2 2011 DEX significantly inhibited lymphocyte proliferation and expression of interferon (IFN)-gamma, interleukin (IL)-2 and IL-4 messenger RNA (mRNA) in comparison with FLU and MEL. Dexamethasone 0-3 interferon gamma Bos taurus 71-93 21349168-9 2011 EDN-1/2/3, LTC4 and PGF2alpha synthases protein expression were elevated in the presence of TNFalpha/IFNgamma, and accompanied by increased EDN-1, LTC4 and PGF2alpha secretion. Dinoprost 20-29 interferon gamma Bos taurus 101-109 19187963-7 2010 Maintenance of the LppA-specific response, relying on CD4 T-cells and IFN gamma production, was then demonstrated 1 year after infection. hydratropic acid 19-23 interferon gamma Bos taurus 70-79 19620347-5 2009 The present study showed that induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) is responsible for the inhibition of parasite growth that is mediated by IFN-gamma-activated bovine fibroblasts and endothelial cells. Tryptophan 47-57 interferon gamma Bos taurus 182-191 20307272-5 2010 IFN-gamma did not affect IL-1beta induced tissue inhibitor of metalloproteinase-1 (TIMP-1) production by RA FLS but skewed the MMP/TIMP-1 balance sufficiently to attenuate glycosaminoglycan-depletion in our BACE model. Glycosaminoglycans 172-189 interferon gamma Bos taurus 0-9 18789542-4 2008 In vitro incubation of bovine peripheral blood mononuclear cells (PBMCs) with ORN-induced production of IL-12, IFN-gamma and TNF-alpha. Oligoribonucleotides 78-81 interferon gamma Bos taurus 111-120 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. chromaffin 278-288 interferon gamma Bos taurus 0-8 19141072-7 2009 In addition, IFNgamma and LPS induce (847)SernNOS phosphorylation, inhibiting nNOS activity. sernnos 42-49 interferon gamma Bos taurus 13-21 19014336-6 2009 Bovine CPC significantly stimulated the release of IFN-gamma, IL-10, and IL-2 (p < 0.03). cpc 7-10 interferon gamma Bos taurus 51-60 19428829-5 2009 Cattle immunized with HEL co-adjuvanted with CpG+indol+PP developed higher antigen-specific humoral responses, and long-lasting cell-mediated immune responses, as evidenced by elevated levels of IFN-gamma secretion by re-stimulated PBMCs, that were superior even to EMULSIGEN((R)), an oil-in-water based adjuvant that was used as positive control. indole 49-54 interferon gamma Bos taurus 195-204 19141072-4 2009 On the other hand, dexamethasone increases basal nNOS expression but decreases LPS + IFNgamma-induced iNOS expression. Dexamethasone 19-32 interferon gamma Bos taurus 85-93 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. W1400 45-51 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. N(omega)-propylarginine 119-145 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. N(omega)-propylarginine 147-152 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. 3-bromo-7-nitroindazol 155-177 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. 7-nitroindazole 179-183 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. l-methyl thiocitrulline 186-209 interferon gamma Bos taurus 0-8 19141072-5 2009 IFNgamma-induced cell death was abolished by W-1400, a specific iNOS inhibitor, but only partially by nNOS inhibitors [N-omega-propyl- L-arginine (N-PLA), 3-Bromo-7-nitroindazol (7-NI), L-methyl thiocitrulline and N-methyl L-arginine], indicating the main iNOS participation in chromaffin cell death. n-methyl l-arginine 214-233 interferon gamma Bos taurus 0-8 15797477-6 2005 Moreover, the ConA-induced IFN-gamma mRNA expression was partly prevented by genistein, a global PTK inhibitor, and PD-98059, an ERK inhibitor, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 116-124 interferon gamma Bos taurus 27-36 18420616-10 2008 The percentage of IFN-gamma positive lymphocytes and PMN, and the percentage of IL-8 positive PMN, exhibited a sustained increase in secretions from ZTS-treated quarters through the first 2 wk of lactation. zts 149-152 interferon gamma Bos taurus 18-27 18257902-7 2008 IFN-gamma and IL-10 levels in response to PHA in supernatants of MC of neonates were significantly lower compared to that in adults (p < 0.05, Wilcoxon two-sample test). Methylcholanthrene 65-67 interferon gamma Bos taurus 0-9 18022200-11 2007 significantly reduced the incidence and severity of type II bovine collagen (CII)-induced arthritis (CIA), which was associated with the inhibition of CII-specific T cell proliferation and type 1 cytokine (IFN-gamma and IL-2) production. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 77-80 interferon gamma Bos taurus 206-215 16319288-2 2006 Evidence supporting the involvement of an IFNG-inducible enzymatic pathway that degrades tryptophan in IFNG-induced death of bovine luteal cells is presented in this study. Tryptophan 89-99 interferon gamma Bos taurus 42-46 16319288-2 2006 Evidence supporting the involvement of an IFNG-inducible enzymatic pathway that degrades tryptophan in IFNG-induced death of bovine luteal cells is presented in this study. Tryptophan 89-99 interferon gamma Bos taurus 103-107 16319288-3 2006 The IFNG-inducible enzyme indoleamine 2,3-dioxygenase (INDO) catalyzes the first step in a metabolic pathway that degrades tryptophan. Tryptophan 123-133 interferon gamma Bos taurus 4-8 16319288-5 2006 To determine whether INDO participates in IFNG-induced death of bovine luteal cells, an experiment was performed to test the effect of 1-methyl-D-tryptophan (1-MT), an inhibitor of INDO, on IFNG-induced DNA fragmentation in luteal cells. 1-methyltryptophan 135-156 interferon gamma Bos taurus 190-194 16319288-8 2006 Supplementation of IFNG-treated luteal cell cultures with elevated concentrations of tryptophan also prevented IFNG-induced DNA fragmentation. Tryptophan 85-95 interferon gamma Bos taurus 19-23 16319288-8 2006 Supplementation of IFNG-treated luteal cell cultures with elevated concentrations of tryptophan also prevented IFNG-induced DNA fragmentation. Tryptophan 85-95 interferon gamma Bos taurus 111-115 16319288-9 2006 We conclude that INDO participates in IFNG-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs. Tryptophan 130-140 interferon gamma Bos taurus 38-42 16319288-9 2006 We conclude that INDO participates in IFNG-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs. Tryptophan 159-169 interferon gamma Bos taurus 38-42 15993492-7 2005 Exogenous iron was shown to reverse the ability of IFN-gamma/LPS pulsed bovine macrophages to restrict M. bovis replication. Iron 10-14 interferon gamma Bos taurus 51-60 15950430-3 2005 TNFalpha in combination with interferon-gamma reduced progesterone (P4) secretion, increased PGF2alpha and leukotriene C4 (LTC4) production, and induced apoptosis of the luteal cells in vitro. Progesterone 54-66 interferon gamma Bos taurus 29-45 15950430-3 2005 TNFalpha in combination with interferon-gamma reduced progesterone (P4) secretion, increased PGF2alpha and leukotriene C4 (LTC4) production, and induced apoptosis of the luteal cells in vitro. Dinoprost 93-102 interferon gamma Bos taurus 29-45 15950430-3 2005 TNFalpha in combination with interferon-gamma reduced progesterone (P4) secretion, increased PGF2alpha and leukotriene C4 (LTC4) production, and induced apoptosis of the luteal cells in vitro. Leukotriene C4 107-121 interferon gamma Bos taurus 29-45 18463360-4 2008 Prostaglandin E2 (1 microM) and PGF2alpha (1 microM) significantly stimulated progesterone (P4) production and reduced the levels of cell death in the cells cultured with or without tumor necrosis factor alpha (TNF)/interferon gamma (IFNG), in the presence and absence of FAS ligand (P < 0.05). Dinoprostone 0-16 interferon gamma Bos taurus 216-232 18463360-4 2008 Prostaglandin E2 (1 microM) and PGF2alpha (1 microM) significantly stimulated progesterone (P4) production and reduced the levels of cell death in the cells cultured with or without tumor necrosis factor alpha (TNF)/interferon gamma (IFNG), in the presence and absence of FAS ligand (P < 0.05). Dinoprostone 0-16 interferon gamma Bos taurus 234-238 18463360-4 2008 Prostaglandin E2 (1 microM) and PGF2alpha (1 microM) significantly stimulated progesterone (P4) production and reduced the levels of cell death in the cells cultured with or without tumor necrosis factor alpha (TNF)/interferon gamma (IFNG), in the presence and absence of FAS ligand (P < 0.05). Dinoprost 32-41 interferon gamma Bos taurus 216-232 18463360-4 2008 Prostaglandin E2 (1 microM) and PGF2alpha (1 microM) significantly stimulated progesterone (P4) production and reduced the levels of cell death in the cells cultured with or without tumor necrosis factor alpha (TNF)/interferon gamma (IFNG), in the presence and absence of FAS ligand (P < 0.05). Dinoprost 32-41 interferon gamma Bos taurus 234-238 18463360-5 2008 Furthermore, DNA fragmentation induced by TNF/IFNG was observed to be suppressed by PGE2 and PGF2alpha. Dinoprostone 84-88 interferon gamma Bos taurus 46-50 18463360-5 2008 Furthermore, DNA fragmentation induced by TNF/IFNG was observed to be suppressed by PGE2 and PGF2alpha. Dinoprost 93-102 interferon gamma Bos taurus 46-50 18463360-6 2008 Prostaglandin E2 and PGF2alpha also attenuated mRNA expression of caspase 3 and caspase 8, as well as caspase 3 activity (P < 0.05) in TNF/IFNG-treated cells. Dinoprostone 0-16 interferon gamma Bos taurus 142-146 18463360-6 2008 Prostaglandin E2 and PGF2alpha also attenuated mRNA expression of caspase 3 and caspase 8, as well as caspase 3 activity (P < 0.05) in TNF/IFNG-treated cells. Dinoprost 21-30 interferon gamma Bos taurus 142-146 18218610-6 2008 These results suggest that cortisol suppresses TNF-IFNG-induced apoptosis in vitro by reducing apoptosis signals via CASP8 and CASP3 in bovine CL and that the local increase in cortisol production resulting from increased HSD11B1 at the early and midluteal stages helps to maintain CL function by suppressing apoptosis of luteal cells. Hydrocortisone 27-35 interferon gamma Bos taurus 51-55 18218610-6 2008 These results suggest that cortisol suppresses TNF-IFNG-induced apoptosis in vitro by reducing apoptosis signals via CASP8 and CASP3 in bovine CL and that the local increase in cortisol production resulting from increased HSD11B1 at the early and midluteal stages helps to maintain CL function by suppressing apoptosis of luteal cells. Hydrocortisone 177-185 interferon gamma Bos taurus 51-55 16625660-4 2006 Treatment of chromaffin cells with lipopolysaccharide (LPS) or cytokines (interferon-gamma, tumor necrosis factor-alpha) resulted only in apoptotic cell death. chromaffin 13-23 interferon gamma Bos taurus 74-119 16386849-4 2006 However, when rBoIL-12 was subcutaneously administered daily from 2 days before infection to 2 days after infection, a consistent increase of T lymphocytes and an higher expression of interferon-gamma (IFN-gamma) was detected. rboil-12 14-22 interferon gamma Bos taurus 184-200 16386849-4 2006 However, when rBoIL-12 was subcutaneously administered daily from 2 days before infection to 2 days after infection, a consistent increase of T lymphocytes and an higher expression of interferon-gamma (IFN-gamma) was detected. rboil-12 14-22 interferon gamma Bos taurus 202-211 16041025-10 2005 The IFN-gamma-inducing effect of NcAg was blocked by cyclosporine, a specific ligand for CyP, in a dose-dependent manner. Cyclosporine 53-65 interferon gamma Bos taurus 4-13 16041025-11 2005 Furthermore, cyclosporine abolished IFN-gamma production by PBMC from naive cows as well as PBMC and CD4(+) T cells from infected/immunized cows. Cyclosporine 13-25 interferon gamma Bos taurus 36-45 15917109-2 2005 Our results showed that calves treated with combined DNA vaccines in the presence of dimethyldioctyldecyl ammonium bromide (DDA) or saline elicited a strong gamma interferon (IFN-gamma) response 1 or 2 months after the third vaccination. dimethyldioctyldecyl ammonium bromide 85-122 interferon gamma Bos taurus 157-184 15917109-2 2005 Our results showed that calves treated with combined DNA vaccines in the presence of dimethyldioctyldecyl ammonium bromide (DDA) or saline elicited a strong gamma interferon (IFN-gamma) response 1 or 2 months after the third vaccination. dda 124-127 interferon gamma Bos taurus 157-184 14597760-7 2003 The in vitro splenic T cell proliferative response and induction of IFN-gamma to bovine CII stimulation were also significantly reduced in mice treated with CII-DC-AdTRAIL+DOX. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 88-91 interferon gamma Bos taurus 68-77 15621307-4 2005 Following fixation, intracellular IFN-gamma was detected using a FITC-conjugated bovine IFN-gamma-specific monoclonal antibody. Fluorescein-5-isothiocyanate 65-69 interferon gamma Bos taurus 34-43 15621307-4 2005 Following fixation, intracellular IFN-gamma was detected using a FITC-conjugated bovine IFN-gamma-specific monoclonal antibody. Fluorescein-5-isothiocyanate 65-69 interferon gamma Bos taurus 88-97 15271921-6 2004 The IFN-gamma-inducing component of the cell wall was further identified as a proteolytically resistant, non-sodium dodecyl sulfate-soluble component of the mycolylarabinogalactan peptidoglycan. Sodium Dodecyl Sulfate 109-131 interferon gamma Bos taurus 4-13 14597760-7 2003 The in vitro splenic T cell proliferative response and induction of IFN-gamma to bovine CII stimulation were also significantly reduced in mice treated with CII-DC-AdTRAIL+DOX. cii-dc-adtrail 157-171 interferon gamma Bos taurus 68-77 14597760-7 2003 The in vitro splenic T cell proliferative response and induction of IFN-gamma to bovine CII stimulation were also significantly reduced in mice treated with CII-DC-AdTRAIL+DOX. Doxycycline 172-175 interferon gamma Bos taurus 68-77 12938169-7 2003 The levels of kynurenine and tryptophan measured, as the bioactivity of IDO, were significantly different in the IFN-gamma treated fibroblasts, compared to those of controls (P < 0.001). Tryptophan 29-39 interferon gamma Bos taurus 113-122 11825597-6 2002 However, depletion of monocytes (DH59B(+)) completely abrogated the ability of CpG-ODN to stimulate IFN-gamma secretion, and significantly reduced the B-cell proliferative response. dh59b 33-38 interferon gamma Bos taurus 100-109 12938169-5 2003 IDO enzyme activity was evaluated by measurement of kynurenine and tryptophan levels in the IFN-gamma untreated and treated fibroblasts. Kynurenine 52-62 interferon gamma Bos taurus 92-101 12938169-5 2003 IDO enzyme activity was evaluated by measurement of kynurenine and tryptophan levels in the IFN-gamma untreated and treated fibroblasts. Tryptophan 67-77 interferon gamma Bos taurus 92-101 12938169-7 2003 The levels of kynurenine and tryptophan measured, as the bioactivity of IDO, were significantly different in the IFN-gamma treated fibroblasts, compared to those of controls (P < 0.001). Kynurenine 14-24 interferon gamma Bos taurus 113-122 12772856-6 2003 On d 1, concanavalin A-induced interferon-gamma production was lower (P < 0.05) in B, BLA, and BEPI than in C, but there was no difference between BK and C animals. blasticidin S 89-92 interferon gamma Bos taurus 31-47 12052343-5 2002 Culture supernatant from the superinfected cells showed a synergistic effect with recombinant boIL-12 for production of interferon-gamma (IFN-gamma) in bovine peripheral mononuclear cells. boil-12 94-101 interferon gamma Bos taurus 120-136 12052343-5 2002 Culture supernatant from the superinfected cells showed a synergistic effect with recombinant boIL-12 for production of interferon-gamma (IFN-gamma) in bovine peripheral mononuclear cells. boil-12 94-101 interferon gamma Bos taurus 138-147 11943327-5 2002 The purified rboIL-12His was bioactive for induction of IFN-gamma in bovine peripheral blood mononuclear cells (PBMCs) in vitro. rboil-12his 13-24 interferon gamma Bos taurus 56-65 11943331-5 2002 Vaccination with ST-CFP/DEAE-dextran induced high levels of interleukin-2 (IL-2) but low levels of interferon-gamma (IFN-gamma) from whole-blood cultures stimulated with M. tuberculosis ST-CFP in comparison with the strong IFN-gamma and IL-2 responses induced after vaccination with BCG. st-cfp 17-23 interferon gamma Bos taurus 117-126 11943331-5 2002 Vaccination with ST-CFP/DEAE-dextran induced high levels of interleukin-2 (IL-2) but low levels of interferon-gamma (IFN-gamma) from whole-blood cultures stimulated with M. tuberculosis ST-CFP in comparison with the strong IFN-gamma and IL-2 responses induced after vaccination with BCG. st-cfp 17-23 interferon gamma Bos taurus 223-232 11943331-5 2002 Vaccination with ST-CFP/DEAE-dextran induced high levels of interleukin-2 (IL-2) but low levels of interferon-gamma (IFN-gamma) from whole-blood cultures stimulated with M. tuberculosis ST-CFP in comparison with the strong IFN-gamma and IL-2 responses induced after vaccination with BCG. DEAE-Dextran 24-36 interferon gamma Bos taurus 117-126 11943331-5 2002 Vaccination with ST-CFP/DEAE-dextran induced high levels of interleukin-2 (IL-2) but low levels of interferon-gamma (IFN-gamma) from whole-blood cultures stimulated with M. tuberculosis ST-CFP in comparison with the strong IFN-gamma and IL-2 responses induced after vaccination with BCG. DEAE-Dextran 24-36 interferon gamma Bos taurus 223-232 11874859-8 2002 An analysis of the cytokine concentration in culture supernatants indicated that cells treated with MN released TNF-alpha and IFN-gamma from the cells, while the BFA-treated cells released IFN-gamma only. Brefeldin A 162-165 interferon gamma Bos taurus 189-198 11777537-0 2002 IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Nitric Oxide 64-76 interferon gamma Bos taurus 29-38 12951895-0 2003 In vitro effects of 1,25-dihydroxyvitamin D3 on interferon-gamma and tumor necrosis factor-alpha secretion by blood leukocytes from young and adult cattle vaccinated with Mycobacterium bovis BCG. Calcitriol 20-44 interferon gamma Bos taurus 48-96 12951895-14 2003 Vitamin D caused a concentration-dependent decrease in IFN-gamma response and an increase in TNF-alpha response in PWM-stimulated cultures. Vitamin D 0-9 interferon gamma Bos taurus 55-64 12951895-15 2003 These results indicate that animal maturity (i.e., age) and antigenic experience affect IFN-gamma and TNF-alpha secretion by bovine leukocytes and suggest that 1,25-(OH)2D3 can alter secretion of both cytokines under specific conditions of culture. Calcitriol 160-172 interferon gamma Bos taurus 88-97 12072243-5 2002 In contrast, stimulation by Con A or PMA/ionomycin induced efficient replication but only low level IFN-gamma production which was not enhanced by the presence of IL-12. Tetradecanoylphorbol Acetate 37-40 interferon gamma Bos taurus 100-109 12072243-5 2002 In contrast, stimulation by Con A or PMA/ionomycin induced efficient replication but only low level IFN-gamma production which was not enhanced by the presence of IL-12. Ionomycin 41-50 interferon gamma Bos taurus 100-109 10608448-9 1999 Peripheral blood mononuclear cells from animals immunised with the Polygen-adjuvanted tachyzoite preparation produced interferon-gamma concentrations of similar magnitude (P = 0.17) to those from the infected animals. polygen 67-74 interferon gamma Bos taurus 118-134 11598059-5 2001 CD4(+) T lymphocytes participate in protective immunity to ehrlichial pathogens through production of gamma interferon (IFN-gamma), which promotes switching to high-affinity immunoglobulin G (IgG) and activation of phagocytic cells to produce nitric oxide. Nitric Oxide 243-255 interferon gamma Bos taurus 102-129 10883854-5 2000 In comparisons of the ESAT-6 IFN-gamma test with a PPD IFN-gamma test (using PPDB compared with PPDA), there was a decrease in sensitivity (76.3 per cent vs 89.3 per cent), but a clear increase in specificity (99.2 per cent vs 92.2 per cent). ppdb 77-81 interferon gamma Bos taurus 55-64 10883402-0 2000 Effects of retinoic acid and 1,25-dihydroxyvitamin D3 on IFN-gamma secretion by mononuclear leukocytes from nulliparous and postparturient dairy cattle. Calcitriol 29-53 interferon gamma Bos taurus 57-66 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Tretinoin 54-67 interferon gamma Bos taurus 120-136 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Tretinoin 54-67 interferon gamma Bos taurus 138-147 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Tretinoin 69-71 interferon gamma Bos taurus 120-136 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Tretinoin 69-71 interferon gamma Bos taurus 138-147 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Calcitriol 77-101 interferon gamma Bos taurus 120-136 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Calcitriol 77-101 interferon gamma Bos taurus 138-147 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Calcitriol 103-115 interferon gamma Bos taurus 120-136 10883402-1 2000 Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. Calcitriol 103-115 interferon gamma Bos taurus 138-147 10883402-5 2000 Furthermore 1,25-dihydroxyvitamin D3 inhibited IFN-gamma secretion by MNL from nulliparous and postparturient dairy cows; however, the degree of inhibition was greater when 9-cis- and 9,13-dicis-RA were also present in the cultures. Calcitriol 12-36 interferon gamma Bos taurus 47-56 10883402-9 2000 Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. Calcitriol 37-49 interferon gamma Bos taurus 14-23 10883402-9 2000 Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. 9-cis- and 9,13-di-cis-retinoics acids 69-107 interferon gamma Bos taurus 14-23 10598072-6 1999 Lymphocyte proliferation in the presence of phytohaemagglutinin, and serum concentrations of IgM, but not IgA or IgG1, were suppressed by dexamethasone treatment, whereas mitogen-induced production of interferon-gamma (IFN-gamma), neutrophil expression of CD18, neutrophil myeloperoxidase activity and natural killer (NK) cell activity were not influenced by dexamethasone treatment. Dexamethasone 138-151 interferon gamma Bos taurus 201-217 10598072-6 1999 Lymphocyte proliferation in the presence of phytohaemagglutinin, and serum concentrations of IgM, but not IgA or IgG1, were suppressed by dexamethasone treatment, whereas mitogen-induced production of interferon-gamma (IFN-gamma), neutrophil expression of CD18, neutrophil myeloperoxidase activity and natural killer (NK) cell activity were not influenced by dexamethasone treatment. Dexamethasone 138-151 interferon gamma Bos taurus 219-228 10598072-6 1999 Lymphocyte proliferation in the presence of phytohaemagglutinin, and serum concentrations of IgM, but not IgA or IgG1, were suppressed by dexamethasone treatment, whereas mitogen-induced production of interferon-gamma (IFN-gamma), neutrophil expression of CD18, neutrophil myeloperoxidase activity and natural killer (NK) cell activity were not influenced by dexamethasone treatment. Dexamethasone 359-372 interferon gamma Bos taurus 201-217 11417702-6 2001 Bovine monocytes produced nitric oxide in response to recombinant bovine interferon-gamma alone or in combination with E. coli lipopolysaccharides. Nitric Oxide 26-38 interferon gamma Bos taurus 73-89 11417702-8 2001 Lipopolysaccharides and recombinant bovine interferon-gamma increased nitric oxide synthase mRNA in neutrophils, but nitric oxide release could not be detected under any of the experimental conditions used. Nitric Oxide 70-82 interferon gamma Bos taurus 43-59 10608448-10 1999 Polygen was one of two adjuvants that elicited the highest antibody responses, and was the only adjuvant that induced interferon-gamma levels similar to those of the infected heifers. polygen 0-7 interferon gamma Bos taurus 118-134 10081758-5 1999 The recombinant IL-2, IL-6 and IFN-gamma could be obtained by the batch method using Glutathione Sepharose 4B and Factor Xa digestion, which may be useful for preparation of antisera as antigens and functional studies. Glutathione 85-96 interferon gamma Bos taurus 31-40 10491412-6 1999 Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma. Gangliosides 0-12 interferon gamma Bos taurus 204-213 10491412-6 1999 Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma. Gangliosides 76-88 interferon gamma Bos taurus 204-213 9927338-5 1999 Densitometric intensities of the electrophoresed IFN-gamma PCR products revealed a drop in RNA expression during late diestrus and at one hour of prostaglandin-induced luteolysis (P < 0.05). Prostaglandins 146-159 interferon gamma Bos taurus 49-58 10385220-1 1999 The effects of interferons (IFNs) IFN-alpha, IFN-beta and IFN-gamma on the production of cortisol in bovine adrenal fasciculata cells have been investigated. Hydrocortisone 89-97 interferon gamma Bos taurus 58-67 10081758-5 1999 The recombinant IL-2, IL-6 and IFN-gamma could be obtained by the batch method using Glutathione Sepharose 4B and Factor Xa digestion, which may be useful for preparation of antisera as antigens and functional studies. Sepharose 97-106 interferon gamma Bos taurus 31-40 10066124-4 1998 IFN-gamma was detected earlier with LLO than with SA. sa 50-52 interferon gamma Bos taurus 0-9 9767609-9 1998 Recombinant interleukin-10 suppressed interferon-gamma-induced nitric oxide and tumour necrosis factor-alpha secretion, but not lipopolysaccharide-induced nitric oxide secretion in cultures of peripheral blood mononuclear cells and monocytes of uninfected cattle. Nitric Oxide 63-75 interferon gamma Bos taurus 38-54 9743615-3 1998 An analog peptide L142I with a substitution of Ile for Leu at the nonanchor N-terminal residue induced more IFN-gamma secretion than p142-149 from specific CD8(+) T cells. Isoleucine 47-50 interferon gamma Bos taurus 108-117 9743615-3 1998 An analog peptide L142I with a substitution of Ile for Leu at the nonanchor N-terminal residue induced more IFN-gamma secretion than p142-149 from specific CD8(+) T cells. Leucine 55-58 interferon gamma Bos taurus 108-117 9767609-5 1998 Interferon-gamma-induced nitric oxide production was decreased between days 25 and 76 of infection, while lipopolysaccharide-induced secretion of nitric oxide was increased at days 13 and again at day 76 post-infection. Nitric Oxide 25-37 interferon gamma Bos taurus 0-16 9767609-10 1998 These results suggest that the nitric oxide response of monocytes to IFN-gamma but not lipopolysaccharide, is suppressed during infection. Nitric Oxide 31-43 interferon gamma Bos taurus 69-78 9767609-7 1998 Analysis of interleukin-10 mRNA transcription in peripheral blood leucocytes revealed an increase at time points that coincided with decreased interferon-gamma-induced nitric oxide synthesis. Nitric Oxide 168-180 interferon gamma Bos taurus 143-159 9723778-2 1998 Incubation of M. bovis BCG-infected macrophages with recombinant bovine IFN-gamma led to increased nitrite levels in culture supernatants. Nitrites 99-106 interferon gamma Bos taurus 72-81 9405417-3 1997 These types of interferons did not aid LPS in the production of nitrite, but markedly inhibited in a concentration-dependent manner the nitrite release due to LPS/IFN-gamma. Nitrites 136-143 interferon gamma Bos taurus 163-172 9688852-3 1998 The LPS-IFN-gamma-induced nitrite release was inhibited in a concentration-dependent manner by these compounds. Nitrites 26-33 interferon gamma Bos taurus 8-17 9688852-9 1998 Furthermore, the LPS-IFN-gamma-induced NOS-II mRNA accumulation was sensitive to cycloheximide, suggesting that, in addition to NF-kappaB, transcriptional factors that require new protein synthesis are involved in NOS-II induction. Cycloheximide 81-94 interferon gamma Bos taurus 21-30 9712367-7 1998 Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels. Gangliosides 10-22 interferon gamma Bos taurus 125-134 9712367-7 1998 Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels. Gangliosides 37-49 interferon gamma Bos taurus 125-134 9712367-7 1998 Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels. G(M1) Ganglioside 63-66 interferon gamma Bos taurus 125-134 9331268-5 1997 RESULTS: Exposure of BCE cells and keratocytes to LPS and IFN-gamma resulted in an increase of nitrite levels that was potentiate by the addition of TNF-alpha. Nitrites 95-102 interferon gamma Bos taurus 58-67 9361213-2 1997 In vivo administration of dexamethasone caused a > or = 97% reduction in in vitro secretion of interferon-gamma by pokeweed mitogen-stimulated mononuclear leukocytes by d 2 after the first treatment. Dexamethasone 26-39 interferon gamma Bos taurus 98-114 9331268-7 1997 Stereoselective inhibitors of NOS and cycloheximide inhibited LPS-IFN-gamma-induced nitrite release in both cells, whereas transforming growth factor-beta (TGF-beta) slightly potentiated it. Cycloheximide 38-51 interferon gamma Bos taurus 66-75 9331268-7 1997 Stereoselective inhibitors of NOS and cycloheximide inhibited LPS-IFN-gamma-induced nitrite release in both cells, whereas transforming growth factor-beta (TGF-beta) slightly potentiated it. Nitrites 84-91 interferon gamma Bos taurus 66-75 9331268-8 1997 Fibroblast growth factor-2 (FGF-2) inhibited LPS-IFN-gamma-induced nitrite release and NOS-2 messenger RNA accumulation in keratocytes but not in BCE cells. Nitrites 67-74 interferon gamma Bos taurus 49-58 8928946-6 1995 In vitro production of interferon-gamma by lymphocytes incubated with bovine purified protein derivative also was significantly lower (P < 0.01) in the dexamethasone treated cattle. Dexamethasone 155-168 interferon gamma Bos taurus 23-39 8759126-0 1996 Mononucleotide repeat polymorphism within intron 1 of the bovine interferon-gamma gene. mononucleotide 0-14 interferon gamma Bos taurus 65-81 8685546-1 1996 Bovine monocytes freshly isolated from peripheral blood were induced to produce nitric oxide by exposing them to recombinant bovine interferon gamma (rbIFN-y) and Escherichia coli lipopolysaccharide (LPS) in vitro. Nitric Oxide 80-92 interferon gamma Bos taurus 132-157 8745265-3 1996 AMs stimulated with lipopolysaccaride (LPS) for four hours in vitro expressed IL-1 alpha, IL-1 beta, IL-6, TNF alpha and GM-CSF; PBMCs stimulated with LPS for four hours expressed IL-1 alpha, IL-1 beta, IL-6, TNF alpha and GM-CSF and when stimulated with concanavalin A (ConA) expressed IL-2, IL-4, IFN gamma and GM-CSF efficiently. lipopolysaccaride 20-37 interferon gamma Bos taurus 299-308 8807778-0 1996 1,25-Dihydroxyvitamin D3 inhibits secretion of interferon-gamma by mitogen- and antigen-stimulated bovine mononuclear leukocytes. Calcitriol 0-24 interferon gamma Bos taurus 47-63 8807778-2 1996 Vitamin D-induced inhibition of IFN-gamma production was most pronounced in MNL cultures supplemented with 1,25(OH)2D3 at 1.0 nM or more, a concentration equal to or exceeding that in plasma of cows with clinical hypocalcemia. Vitamin D 0-9 interferon gamma Bos taurus 32-41 8807778-2 1996 Vitamin D-induced inhibition of IFN-gamma production was most pronounced in MNL cultures supplemented with 1,25(OH)2D3 at 1.0 nM or more, a concentration equal to or exceeding that in plasma of cows with clinical hypocalcemia. Calcitriol 107-118 interferon gamma Bos taurus 32-41 7761113-1 1995 Nitric oxide (NO) was produced when bovine peripheral blood mononuclear cells (PBMC) or purified, adherent PBMC (macrophages) were incubated in vitro with bovine recombinant interferon gamma (Bo rIFN-gamma). Nitric Oxide 0-12 interferon gamma Bos taurus 174-190 7541352-1 1995 Bovine retinal pigmented epithelial cells (RPE cells), after activation with interferon gamma (IFN gamma) and lipopolysaccharide (LPS), express an inducible nitric oxide (NO) synthase. Nitric Oxide 157-169 interferon gamma Bos taurus 77-93 7541352-1 1995 Bovine retinal pigmented epithelial cells (RPE cells), after activation with interferon gamma (IFN gamma) and lipopolysaccharide (LPS), express an inducible nitric oxide (NO) synthase. Nitric Oxide 157-169 interferon gamma Bos taurus 95-104 8312225-5 1993 By blocking thiol and serine proteases with specific inhibitors or by raising the intracellular pH with chloroquine during BI pulse, the presentation capacity of IFN-gamma-activated BMMph was significantly enhanced, while the presentation function of GM-CSF-pulsed macrophages was not positively influenced. Sulfhydryl Compounds 12-17 interferon gamma Bos taurus 162-171 8546801-6 1995 In addition, lymphocytes stimulated with gD or peptide 77 (residues 161-172) also produced IFN-gamma and IL-2. Gadolinium 41-43 interferon gamma Bos taurus 91-100 8001633-2 1994 Interferon-gamma pretreatment for 20 h markedly attenuated the endothelium-dependent bradykinin relaxation in arteries precontracted with 9,11-dideoxy-11 alpha,9 alpha-epoxymethano prostaglandin F2 alpha (U46619), and the relaxation was reversed to contraction at the highest bradykinin concentrations (-72 +/- 5% for control vs. + 6 +/- 10% for interferon-gamma). 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 138-203 interferon gamma Bos taurus 0-16 8001633-2 1994 Interferon-gamma pretreatment for 20 h markedly attenuated the endothelium-dependent bradykinin relaxation in arteries precontracted with 9,11-dideoxy-11 alpha,9 alpha-epoxymethano prostaglandin F2 alpha (U46619), and the relaxation was reversed to contraction at the highest bradykinin concentrations (-72 +/- 5% for control vs. + 6 +/- 10% for interferon-gamma). 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 205-211 interferon gamma Bos taurus 0-16 8001633-3 1994 Cycloheximide (20 micrograms ml-1) present during the 20-h preincubation completely prevented the interferon-gamma effect. Cycloheximide 0-13 interferon gamma Bos taurus 98-114 8001633-4 1994 Methyl-L-arginine (1 mM) treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation (-47 +/- 18% for interferon-gamma and methyl-L-arginine), which suggests involvement of nitric oxide during the 20-h preincubation with interferon-gamma. arginine methyl ester 0-17 interferon gamma Bos taurus 84-100 8001633-4 1994 Methyl-L-arginine (1 mM) treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation (-47 +/- 18% for interferon-gamma and methyl-L-arginine), which suggests involvement of nitric oxide during the 20-h preincubation with interferon-gamma. arginine methyl ester 0-17 interferon gamma Bos taurus 150-166 8001633-4 1994 Methyl-L-arginine (1 mM) treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation (-47 +/- 18% for interferon-gamma and methyl-L-arginine), which suggests involvement of nitric oxide during the 20-h preincubation with interferon-gamma. arginine methyl ester 0-17 interferon gamma Bos taurus 150-166 8001633-4 1994 Methyl-L-arginine (1 mM) treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation (-47 +/- 18% for interferon-gamma and methyl-L-arginine), which suggests involvement of nitric oxide during the 20-h preincubation with interferon-gamma. arginine methyl ester 171-188 interferon gamma Bos taurus 84-100 8001633-4 1994 Methyl-L-arginine (1 mM) treatment during the 20-h preincubation also inhibited the interferon-gamma effect on bradykinin relaxation (-47 +/- 18% for interferon-gamma and methyl-L-arginine), which suggests involvement of nitric oxide during the 20-h preincubation with interferon-gamma. Nitric Oxide 221-233 interferon gamma Bos taurus 84-100 8001633-8 1994 Firstly, prolonged nitric oxide release induced by interferon-gamma during the 20-h preincubation may inhibit bradykinin stimulated endothelium-derived nitric oxide release and action. Nitric Oxide 19-31 interferon gamma Bos taurus 51-67 7509393-0 1994 Induction of nitric oxide release by interferon-gamma inhibits vasodilation and cyclic GMP increase in bovine isolated mesenteric arteries. Nitric Oxide 13-25 interferon gamma Bos taurus 37-53 7509393-0 1994 Induction of nitric oxide release by interferon-gamma inhibits vasodilation and cyclic GMP increase in bovine isolated mesenteric arteries. Cyclic GMP 80-90 interferon gamma Bos taurus 37-53 7509393-3 1994 Treatment with IFN-gamma markedly inhibited endothelium-dependent relaxation to bradykinin and impaired vasodilation to nitroprusside, which was endothelium-independent. Nitroprusside 120-133 interferon gamma Bos taurus 15-24 7509393-6 1994 Nitrite concentration in the incubation medium was increased after IFN-gamma, which indicates the induction of nitric oxide release during the incubation period. Nitrites 0-7 interferon gamma Bos taurus 67-76 7509393-6 1994 Nitrite concentration in the incubation medium was increased after IFN-gamma, which indicates the induction of nitric oxide release during the incubation period. Nitric Oxide 111-123 interferon gamma Bos taurus 67-76 7509393-7 1994 Inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine during the 20-hr incubation with IFN-gamma completely prevented the decrease in relaxation and cGMP elevation to nitroprusside. Nitric Oxide 14-26 interferon gamma Bos taurus 100-109 7509393-7 1994 Inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine during the 20-hr incubation with IFN-gamma completely prevented the decrease in relaxation and cGMP elevation to nitroprusside. omega-N-Methylarginine 42-66 interferon gamma Bos taurus 100-109 7509393-7 1994 Inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine during the 20-hr incubation with IFN-gamma completely prevented the decrease in relaxation and cGMP elevation to nitroprusside. Cyclic GMP 162-166 interferon gamma Bos taurus 100-109 7509393-7 1994 Inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine during the 20-hr incubation with IFN-gamma completely prevented the decrease in relaxation and cGMP elevation to nitroprusside. Nitroprusside 180-193 interferon gamma Bos taurus 100-109 7509393-8 1994 We conclude that IFN-gamma induces a marked increase in release of arterial-derived nitric oxide resulting in a desensitization of guanylate cyclase, which contributes to a decrease in relaxation to bradykinin and nitroprusside. Nitric Oxide 84-96 interferon gamma Bos taurus 17-26 7509393-8 1994 We conclude that IFN-gamma induces a marked increase in release of arterial-derived nitric oxide resulting in a desensitization of guanylate cyclase, which contributes to a decrease in relaxation to bradykinin and nitroprusside. Nitroprusside 214-227 interferon gamma Bos taurus 17-26 7507664-5 1994 Bacteria-induced NO2- production was enhanced by concomittant exposure to interferon-gamma, tumor necrosis factor-alpha or both combined, although these cytokines alone (in the absence of bacteria) induced little NO2-. Nitrogen Dioxide 17-20 interferon gamma Bos taurus 74-119 8001633-8 1994 Firstly, prolonged nitric oxide release induced by interferon-gamma during the 20-h preincubation may inhibit bradykinin stimulated endothelium-derived nitric oxide release and action. Nitric Oxide 152-164 interferon gamma Bos taurus 51-67 8312225-5 1993 By blocking thiol and serine proteases with specific inhibitors or by raising the intracellular pH with chloroquine during BI pulse, the presentation capacity of IFN-gamma-activated BMMph was significantly enhanced, while the presentation function of GM-CSF-pulsed macrophages was not positively influenced. Chloroquine 104-115 interferon gamma Bos taurus 162-171 8325319-6 1993 Because processing of insulin depends on reduction of disulfide bonds, we analyzed the content of intracellular reducing thiols within IFN-gamma-M phi, GM-CSF-M phi, and untreated BMM phi. Sulfhydryl Compounds 121-127 interferon gamma Bos taurus 135-144 8376939-2 1993 Before treatment with gangliosides, astrocytes expressed constitutive MHC class I but not class II molecules, however, the expression of both MHC class I and II cell surface molecules on astrocytes was induced to high levels by interferon gamma (IFN-gamma). Gangliosides 22-34 interferon gamma Bos taurus 228-255 8376939-3 1993 Constitutive and IFN-gamma-inducible expression of MHC class I and II molecules was suppressed by treatment of astrocytes with exogenous bovine brain gangliosides in a dose-dependent manner. Gangliosides 150-162 interferon gamma Bos taurus 17-26 8408457-2 1993 Incubation of Graves" thyroid cells with 1.0 U/L bovine TSH or 1.0 mM 8-bromo-cAMP resulted in a 2-fold increase in TSH receptor mRNA expression, which was markedly inhibited in the presence of IFN gamma in a dose- and time-dependent manner. 8-Bromo Cyclic Adenosine Monophosphate 70-82 interferon gamma Bos taurus 194-203 8325319-8 1993 These findings suggest that the lymphokines IFN-gamma and GM-CSF differently interfere with the processing capacity of BMM phi by differently regulating the intracellular concentration of the thiols reduced glutathione and cysteine. Sulfhydryl Compounds 192-198 interferon gamma Bos taurus 44-53 8325319-8 1993 These findings suggest that the lymphokines IFN-gamma and GM-CSF differently interfere with the processing capacity of BMM phi by differently regulating the intracellular concentration of the thiols reduced glutathione and cysteine. Glutathione 207-218 interferon gamma Bos taurus 44-53 8325319-8 1993 These findings suggest that the lymphokines IFN-gamma and GM-CSF differently interfere with the processing capacity of BMM phi by differently regulating the intracellular concentration of the thiols reduced glutathione and cysteine. Cysteine 223-231 interferon gamma Bos taurus 44-53 1379808-1 1992 The present study demonstrates that bovine retinal pigmented epithelial cells, which are neuroectodermal in origin, produce nitric oxide (NO) upon treatment with interferon-gamma in the presence of lipopolysaccharide or tumor necrosis factor-alpha. Nitric Oxide 124-136 interferon gamma Bos taurus 162-178 8432989-2 1993 The IFN-gamma-induced surface expression of MHC class II molecules on those cells is stimulated by catecholamines through a cAMP-independent mechanism. Catecholamines 99-113 interferon gamma Bos taurus 4-13 8432989-2 1993 The IFN-gamma-induced surface expression of MHC class II molecules on those cells is stimulated by catecholamines through a cAMP-independent mechanism. Cyclic AMP 124-128 interferon gamma Bos taurus 4-13 8432989-3 1993 We report that both the induction of MHC class II molecule expression by IFN-gamma and its potentiation by isoproterenol, a catecholamine analog, are preceded by increases of steady-state levels of the corresponding mRNA. Isoproterenol 107-120 interferon gamma Bos taurus 73-82 8432989-3 1993 We report that both the induction of MHC class II molecule expression by IFN-gamma and its potentiation by isoproterenol, a catecholamine analog, are preceded by increases of steady-state levels of the corresponding mRNA. Catecholamines 124-137 interferon gamma Bos taurus 73-82 7683432-3 1993 Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration-dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma-induced NOS activity. Nitrites 71-78 interferon gamma Bos taurus 128-137 7683432-3 1993 Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration-dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma-induced NOS activity. Nitrites 190-197 interferon gamma Bos taurus 217-226 7683432-6 1993 Results with heparin, suramin, and tyrphostin suggest involvement of the high-affinity receptor for FGF in its inhibition of LPS/IFN-gamma-stimulated NOS activity. Tyrphostins 35-45 interferon gamma Bos taurus 129-138 1717565-0 1991 Catecholamines stimulate the IFN-gamma-induced class II MHC expression on bovine brain capillary endothelial cells. Catecholamines 0-14 interferon gamma Bos taurus 29-38 2110791-9 1990 Recombinant bovine interferon gamma treatment resulted in reduction in pneumonic lung volume and severity of pneumonia in dexamethasone-treated calves (P less than 0.05), although it did not influence severity of pneumonia in nondexamethasone-treated calves. Dexamethasone 122-135 interferon gamma Bos taurus 19-35 1901229-4 1991 After a 24-h exposure to IFN-gamma (100 U), both PGF2 alpha and 6-keto-PGF1 alpha production were decreased approximately 50% (p less than 0.05). Dinoprost 49-53 interferon gamma Bos taurus 25-34 1901229-4 1991 After a 24-h exposure to IFN-gamma (100 U), both PGF2 alpha and 6-keto-PGF1 alpha production were decreased approximately 50% (p less than 0.05). -keto-pgf1 65-75 interferon gamma Bos taurus 25-34 1901229-5 1991 However, as time in culture progressed, IFN-gamma markedly increased the synthesis of both prostaglandins approximately 400% above controls (p less than 0.05). Prostaglandins 91-105 interferon gamma Bos taurus 40-49 1901229-6 1991 Stimulation of prostaglandin production by IFN-gamma was abrogated by the addition of exogenous P4. Prostaglandins 15-28 interferon gamma Bos taurus 43-52 1901229-7 1991 During the period of IFN-gamma-stimulated prostaglandin synthesis, LH-stimulated P4 production was inhibited by IFN-gamma treatment. Prostaglandins 42-55 interferon gamma Bos taurus 21-30 1901229-7 1991 During the period of IFN-gamma-stimulated prostaglandin synthesis, LH-stimulated P4 production was inhibited by IFN-gamma treatment. Luteinizing Hormone 67-69 interferon gamma Bos taurus 112-121 1901229-9 1991 These results suggest that IFN-gamma, in addition to an indirect role in promoting immune response mechanisms, may also directly affect luteal function by enhancing luteal prostaglandin synthesis and by inhibiting luteal steroidogenesis. Prostaglandins 172-185 interferon gamma Bos taurus 27-36 2173451-2 1990 Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Calcimycin 128-134 interferon gamma Bos taurus 55-71 2173451-2 1990 Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Arachidonic Acid 155-171 interferon gamma Bos taurus 55-71 2173451-2 1990 Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Thromboxane B2 224-228 interferon gamma Bos taurus 55-71 2173451-2 1990 Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Dinoprost 233-243 interferon gamma Bos taurus 55-71 2173451-2 1990 Alveolar macrophages incubated with recombinant bovine interferon-gamma or lipopolysaccharide, and subsequently stimulated with A23187 or OPZ, had altered arachidonic acid metabolism, producing markedly increased amounts of TXB2 and PGF2 alpha, and slightly increased LTB4. Leukotriene B4 268-272 interferon gamma Bos taurus 55-71 2125019-5 1990 A reduction in IFN-G-induced MHC class II expression was observed with dexamethasone, prostaglandin E2 and alpha-interferon. Dexamethasone 71-84 interferon gamma Bos taurus 15-20 2125019-5 1990 A reduction in IFN-G-induced MHC class II expression was observed with dexamethasone, prostaglandin E2 and alpha-interferon. Dinoprostone 86-102 interferon gamma Bos taurus 15-20 33814155-7 2021 Greater dietary MP concentration (D-MP vs. A-MP and Blend) decreased expression of genes related to protein synthesis (MTOR, RPS6KB1) and degradation (FOXO1), inflammation (IFNG, TLR4), and endoplasmic reticulum (ER) stress (HSPA5, DDIT) and increased genes associated with lipogenesis (PPARG) and glucose oxidation (LDH, MB). mp 16-18 interferon gamma Bos taurus 173-177 35094866-9 2022 The PBMC also showed a decrease in the secretion of IFN-gamma in response to lauric, linolenic, palmitoleic, and stearic acids at 50 microM and myristic acid at 100 microM. lauric 77-83 interferon gamma Bos taurus 52-61 35094866-9 2022 The PBMC also showed a decrease in the secretion of IFN-gamma in response to lauric, linolenic, palmitoleic, and stearic acids at 50 microM and myristic acid at 100 microM. linolenic 85-94 interferon gamma Bos taurus 52-61 35094866-9 2022 The PBMC also showed a decrease in the secretion of IFN-gamma in response to lauric, linolenic, palmitoleic, and stearic acids at 50 microM and myristic acid at 100 microM. palmitoleic 96-107 interferon gamma Bos taurus 52-61 35094866-9 2022 The PBMC also showed a decrease in the secretion of IFN-gamma in response to lauric, linolenic, palmitoleic, and stearic acids at 50 microM and myristic acid at 100 microM. Stearic Acids 113-126 interferon gamma Bos taurus 52-61 35094866-9 2022 The PBMC also showed a decrease in the secretion of IFN-gamma in response to lauric, linolenic, palmitoleic, and stearic acids at 50 microM and myristic acid at 100 microM. Myristic Acid 144-157 interferon gamma Bos taurus 52-61 35094866-11 2022 In addition, we detected an inverse relationship between the melting points of fatty acids and their ability to inhibit IL-4 and IFN-gamma secretions, as evidenced by greater inhibition with low-melting point fatty acids. Fatty Acids 79-90 interferon gamma Bos taurus 129-138 35094866-11 2022 In addition, we detected an inverse relationship between the melting points of fatty acids and their ability to inhibit IL-4 and IFN-gamma secretions, as evidenced by greater inhibition with low-melting point fatty acids. Fatty Acids 209-220 interferon gamma Bos taurus 129-138 35263339-9 2022 In vitro analyses indicated that estradiol suppressed IFN-gamma production, at least in part, via PGE2/EP4 signaling. Estradiol 33-42 interferon gamma Bos taurus 54-63 35263339-9 2022 In vitro analyses indicated that estradiol suppressed IFN-gamma production, at least in part, via PGE2/EP4 signaling. Dinoprostone 98-102 interferon gamma Bos taurus 54-63 35211544-6 2022 Treatment with 1,25(OH)2D3 resulted in decreased secretion for some pro-inflammatory cytokines in clinical animals, including IL-1beta, IL-6, and IFN-gamma. Calcitriol 15-26 interferon gamma Bos taurus 146-155 35111692-11 2021 1,25(OH)2D3 treatment played a key role in upregulating secretion of pro-inflammatory cytokines IL-1beta and IL-12 while downregulating IL-10, IL-6, and IFN-gamma. Calcitriol 0-11 interferon gamma Bos taurus 153-162