PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
27852782-0	2016	Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function.	Docosahexaenoic Acids	83-103	fatty acid binding protein 5, epidermal	Mus musculus	0-28
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Docosahexaenoic Acids	121-124	fatty acid binding protein 5, epidermal	Mus musculus	30-35
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Docosahexaenoic Acids	99-119	fatty acid binding protein 5, epidermal	Mus musculus	0-28
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Docosahexaenoic Acids	99-119	fatty acid binding protein 5, epidermal	Mus musculus	30-35
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Fatty Acids, Unsaturated	143-169	fatty acid binding protein 5, epidermal	Mus musculus	0-28
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Docosahexaenoic Acids	121-124	fatty acid binding protein 5, epidermal	Mus musculus	0-28
27852782-1	2016	Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function.	Fatty Acids, Unsaturated	143-169	fatty acid binding protein 5, epidermal	Mus musculus	30-35
26311517-4	2015	FINDINGS: Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.	Endocannabinoids	77-92	fatty acid binding protein 5, epidermal	Mus musculus	23-28
27852782-4	2016	FABP5-/- mice exhibited impaired working memory and short-term memory, and these cognitive deficits were associated with a 14.7 +- 5.7% reduction in endogenous brain DHA levels.	Docosahexaenoic Acids	166-169	fatty acid binding protein 5, epidermal	Mus musculus	0-5
27852782-5	2016	The role of FABP5 in the blood-brain barrier transport of DHA was assessed by measuring 14C-DHA uptake into brain endothelial cells and capillaries isolated from FABP5+/+ and FABP5-/- mice.	Docosahexaenoic Acids	58-61	fatty acid binding protein 5, epidermal	Mus musculus	12-17
27852782-6	2016	In line with a crucial role of FABP5 in the brain uptake of DHA, 14C-DHA uptake into brain endothelial cells and brain capillaries of FABP5-/- mice was reduced by 48.4 +- 14.5% and 14.0 +- 4.2%, respectively, relative to those of FABP5+/+ mice.	Docosahexaenoic Acids	60-63	fatty acid binding protein 5, epidermal	Mus musculus	31-36
27852782-6	2016	In line with a crucial role of FABP5 in the brain uptake of DHA, 14C-DHA uptake into brain endothelial cells and brain capillaries of FABP5-/- mice was reduced by 48.4 +- 14.5% and 14.0 +- 4.2%, respectively, relative to those of FABP5+/+ mice.	Docosahexaenoic Acids	60-63	fatty acid binding protein 5, epidermal	Mus musculus	134-139
27852782-6	2016	In line with a crucial role of FABP5 in the brain uptake of DHA, 14C-DHA uptake into brain endothelial cells and brain capillaries of FABP5-/- mice was reduced by 48.4 +- 14.5% and 14.0 +- 4.2%, respectively, relative to those of FABP5+/+ mice.	Docosahexaenoic Acids	60-63	fatty acid binding protein 5, epidermal	Mus musculus	134-139
27852782-6	2016	In line with a crucial role of FABP5 in the brain uptake of DHA, 14C-DHA uptake into brain endothelial cells and brain capillaries of FABP5-/- mice was reduced by 48.4 +- 14.5% and 14.0 +- 4.2%, respectively, relative to those of FABP5+/+ mice.	14c-dha	65-72	fatty acid binding protein 5, epidermal	Mus musculus	134-139
27852782-6	2016	In line with a crucial role of FABP5 in the brain uptake of DHA, 14C-DHA uptake into brain endothelial cells and brain capillaries of FABP5-/- mice was reduced by 48.4 +- 14.5% and 14.0 +- 4.2%, respectively, relative to those of FABP5+/+ mice.	14c-dha	65-72	fatty acid binding protein 5, epidermal	Mus musculus	134-139
27852782-7	2016	These results strongly support the hypothesis that FABP5 is essential for maintaining brain endothelial cell uptake of DHA, and that cognitive deficits observed in FABP5-/- mice are associated with reduced CNS access of DHA.	Docosahexaenoic Acids	119-122	fatty acid binding protein 5, epidermal	Mus musculus	51-56
27852782-7	2016	These results strongly support the hypothesis that FABP5 is essential for maintaining brain endothelial cell uptake of DHA, and that cognitive deficits observed in FABP5-/- mice are associated with reduced CNS access of DHA.	Docosahexaenoic Acids	220-223	fatty acid binding protein 5, epidermal	Mus musculus	164-169
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	117-137	fatty acid binding protein 5, epidermal	Mus musculus	44-72
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	117-137	fatty acid binding protein 5, epidermal	Mus musculus	74-79
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	139-142	fatty acid binding protein 5, epidermal	Mus musculus	44-72
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	139-142	fatty acid binding protein 5, epidermal	Mus musculus	74-79
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	246-249	fatty acid binding protein 5, epidermal	Mus musculus	44-72
27852782-8	2016	SIGNIFICANCE STATEMENT: Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA.	Docosahexaenoic Acids	246-249	fatty acid binding protein 5, epidermal	Mus musculus	74-79
27852782-9	2016	Therefore, FABP5 in the brain endothelial cell is a crucial contributor to the brain levels of DHA.	Docosahexaenoic Acids	95-98	fatty acid binding protein 5, epidermal	Mus musculus	11-16
27852782-10	2016	Critically, lowered brain DHA levels in FABP5-/- mice occurred in tandem with cognitive deficits in a battery of memory paradigms.	Docosahexaenoic Acids	26-29	fatty acid binding protein 5, epidermal	Mus musculus	40-45
27852782-11	2016	This study provides evidence of a critical role for FABP5 in the maintenance of cognitive function via regulating the brain uptake of DHA, and suggests that upregulation of FABP5 in neurodegenerative diseases, where brain DHA levels are possibly diminished (e.g., Alzheimer"s disease), may provide a novel therapeutic approach for restoring cognitive function.	Docosahexaenoic Acids	134-137	fatty acid binding protein 5, epidermal	Mus musculus	52-57
27852782-11	2016	This study provides evidence of a critical role for FABP5 in the maintenance of cognitive function via regulating the brain uptake of DHA, and suggests that upregulation of FABP5 in neurodegenerative diseases, where brain DHA levels are possibly diminished (e.g., Alzheimer"s disease), may provide a novel therapeutic approach for restoring cognitive function.	Docosahexaenoic Acids	222-225	fatty acid binding protein 5, epidermal	Mus musculus	52-57
27852782-11	2016	This study provides evidence of a critical role for FABP5 in the maintenance of cognitive function via regulating the brain uptake of DHA, and suggests that upregulation of FABP5 in neurodegenerative diseases, where brain DHA levels are possibly diminished (e.g., Alzheimer"s disease), may provide a novel therapeutic approach for restoring cognitive function.	Docosahexaenoic Acids	222-225	fatty acid binding protein 5, epidermal	Mus musculus	173-178
27092087-3	2016	These findings facilitated the recent development of SBFI26, a pharmacological inhibitor of epidermal- and brain-specific FABP5 and FABP7, which effectively increases anandamide signaling.	1-naphthyl alpha-truxillate	53-59	fatty acid binding protein 5, epidermal	Mus musculus	122-127
27092087-3	2016	These findings facilitated the recent development of SBFI26, a pharmacological inhibitor of epidermal- and brain-specific FABP5 and FABP7, which effectively increases anandamide signaling.	anandamide	167-177	fatty acid binding protein 5, epidermal	Mus musculus	122-127
26455443-11	2015	Relative to FABP5(+/+) mice, the Kin of (14)C-DHA decreased 36.7 +- 12.4% in FABP5(-/-) mice.	Docosahexaenoic Acids	46-49	fatty acid binding protein 5, epidermal	Mus musculus	77-82
26919975-6	2016	Quantitative reverse transcription-polymerase chain reaction from endometriotic cells treated with fenretinide was used to examine expression of genes involved in RA signaling including stimulated by RA 6 (STRA6), cellular RA binding protein 2 (CRABP2), and fatty acid binding protein 5 (FABP5).	Fenretinide	99-110	fatty acid binding protein 5, epidermal	Mus musculus	258-286
26919975-6	2016	Quantitative reverse transcription-polymerase chain reaction from endometriotic cells treated with fenretinide was used to examine expression of genes involved in RA signaling including stimulated by RA 6 (STRA6), cellular RA binding protein 2 (CRABP2), and fatty acid binding protein 5 (FABP5).	Fenretinide	99-110	fatty acid binding protein 5, epidermal	Mus musculus	288-293
26311517-4	2015	FINDINGS: Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.	anandamide	144-154	fatty acid binding protein 5, epidermal	Mus musculus	23-28
26311517-4	2015	FINDINGS: Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.	N-acylethanolamines	171-190	fatty acid binding protein 5, epidermal	Mus musculus	23-28
26311517-4	2015	FINDINGS: Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.	palmidrol	191-212	fatty acid binding protein 5, epidermal	Mus musculus	23-28
26311517-4	2015	FINDINGS: Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.	oleoylethanolamide	217-235	fatty acid binding protein 5, epidermal	Mus musculus	23-28
25962726-4	2015	RESULTS: We demonstrate that compound [2-(4-acetylphenoxy)-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one; designated as EI-03] bound to the lipid binding pocket of E-FABP and enhanced the expression of peroxisome proliferator-activating receptor (PPAR) gamma.	2-(4-acetylphenoxy)-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one	39-117	fatty acid binding protein 5, epidermal	Mus musculus	177-183
25962726-4	2015	RESULTS: We demonstrate that compound [2-(4-acetylphenoxy)-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one; designated as EI-03] bound to the lipid binding pocket of E-FABP and enhanced the expression of peroxisome proliferator-activating receptor (PPAR) gamma.	ei-03	133-138	fatty acid binding protein 5, epidermal	Mus musculus	177-183
25796556-3	2015	Herein, we report the compound 5-(benzylamino)-2-(3-methylphenyl)-1,3-oxazole-4-carbonitrile (designated EI-05) as a novel E-FABP activator for inhibition of mammary tumor growth.	5-(benzylamino)-2-(3-methylphenyl)-1,3-oxazole-4-carbonitrile	31-92	fatty acid binding protein 5, epidermal	Mus musculus	123-129
25796556-4	2015	EI-05 was selected from the ZINC compound library using molecular docking analysis based on the crystal structure of E-FABP.	ei-05	0-5	fatty acid binding protein 5, epidermal	Mus musculus	117-123
24644281-3	2014	We show further that the fatty acid-binding protein FABP5 controls both of these functions in vivo.	Fatty Acids	25-35	fatty acid binding protein 5, epidermal	Mus musculus	52-57
24879443-0	2014	Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice.	Fatty Acids	24-34	fatty acid binding protein 5, epidermal	Mus musculus	52-58
24879443-2	2014	Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids.	Fatty Acids	0-10	fatty acid binding protein 5, epidermal	Mus musculus	132-138
24879443-2	2014	Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids.	long-chain fatty acids	67-89	fatty acid binding protein 5, epidermal	Mus musculus	132-138
25628425-5	2015	Single oral administration of glucose and fat resulted in a 40% reduction of GIP response to fat but not to glucose in whole body FABP5-knockout (FABP5(-/-)) mice, with no change in K cell count or GIP content in K cells.	Glucose	30-37	fatty acid binding protein 5, epidermal	Mus musculus	146-151
25628425-6	2015	In an ex vivo experiment using isolated upper small intestine, oleic acid induced only a slight increase in GIP release, which was markedly enhanced by coadministration of bile and oleic acid together with attenuated GIP response in the FABP5(-/-) sample.	Oleic Acid	63-73	fatty acid binding protein 5, epidermal	Mus musculus	237-242
25628425-8	2015	These results demonstrate that bile efficiently amplifies fat-induced GIP secretion and that FABP5 contributes to the development of DIO in a GIP-dependent manner.	3,3'-Dioctadecyloxacarbocyanine perchlorate	133-136	fatty acid binding protein 5, epidermal	Mus musculus	93-98
25268051-8	2014	FABP5 promotes intracellular transport and inactivation of endocannabinoids, including anandamide, which inhibits GIP release.	anandamide	87-97	fatty acid binding protein 5, epidermal	Mus musculus	0-5
24879443-2	2014	Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids.	Fatty Acids, Omega-3	160-175	fatty acid binding protein 5, epidermal	Mus musculus	111-130
24879443-2	2014	Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids.	Fatty Acids, Omega-3	160-175	fatty acid binding protein 5, epidermal	Mus musculus	132-138
24879443-11	2014	The present results suggest that fatty acids, preferably n-3 ones, are intracellularly transported by E-FABP to various targets, including mitochondria and nucleus, in which PPARbeta/delta may play functional roles in the transcriptional regulation of genes involved in the endochondral ossification.	Fatty Acids	33-44	fatty acid binding protein 5, epidermal	Mus musculus	102-108
24644281-0	2014	Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in the brain.	anandamide	85-95	fatty acid binding protein 5, epidermal	Mus musculus	0-28
24644281-0	2014	Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) in the brain.	anandamide	85-95	fatty acid binding protein 5, epidermal	Mus musculus	30-35
24644281-4	2014	FABP5 both promotes the hydrolysis of AEA into arachidonic acid and thus reduces brain endocannabinoid levels, and directly shuttles arachidonic acid to the nucleus where it delivers it to PPARbeta/delta, enabling its activation.	anandamide	38-41	fatty acid binding protein 5, epidermal	Mus musculus	0-5
24644281-4	2014	FABP5 both promotes the hydrolysis of AEA into arachidonic acid and thus reduces brain endocannabinoid levels, and directly shuttles arachidonic acid to the nucleus where it delivers it to PPARbeta/delta, enabling its activation.	Arachidonic Acid	47-63	fatty acid binding protein 5, epidermal	Mus musculus	0-5
24644281-4	2014	FABP5 both promotes the hydrolysis of AEA into arachidonic acid and thus reduces brain endocannabinoid levels, and directly shuttles arachidonic acid to the nucleus where it delivers it to PPARbeta/delta, enabling its activation.	Arachidonic Acid	133-149	fatty acid binding protein 5, epidermal	Mus musculus	0-5
24644281-5	2014	In accordance, ablation of FABP5 in mice results in excess accumulation of AEA, abolishes PPARbeta/delta activation in the brain, and markedly impairs hippocampus-based learning and memory.	anandamide	75-78	fatty acid binding protein 5, epidermal	Mus musculus	27-32
24644281-6	2014	The data indicate that, by controlling anandamide disposition and activities, FABP5 plays a key role in regulating hippocampal cognitive function.	anandamide	39-49	fatty acid binding protein 5, epidermal	Mus musculus	78-83
23968980-2	2013	Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium.	Fatty Acids	142-145	fatty acid binding protein 5, epidermal	Mus musculus	89-94
24244493-3	2013	In addition, mice deficient for both FABP4 and FABP5 (FABP4/5 DKO mice) exhibited defective uptake of FA with compensatory up-regulation of glucose consumption in these tissues during fasting.	Glucose	140-147	fatty acid binding protein 5, epidermal	Mus musculus	47-52
16400526-7	2005	The present detection of E-FABP-immunopositivity selectively in macrophages of the atretic follicles suggests possible involvement of E-FABP and/or its ligand fatty acids in the process of follicular atresia, and it makes more reliable the identification of the advanced atretic follicles with the antral spaces obliterated, which could provide further details on the histology of the follicular atresia than before.	Fatty Acids	159-170	fatty acid binding protein 5, epidermal	Mus musculus	25-31
23991366-1	2013	The vitamin A metabolite retinoic acid (RA) regulates gene transcription by activating the nuclear receptors RAR and PPARbeta/delta and their cognate lipid binding proteins CRABP-II, which delivers RA to RAR, and FABP5, which shuttles the hormone to PPARbeta/delta.	Vitamin A	4-13	fatty acid binding protein 5, epidermal	Mus musculus	213-218
23991366-1	2013	The vitamin A metabolite retinoic acid (RA) regulates gene transcription by activating the nuclear receptors RAR and PPARbeta/delta and their cognate lipid binding proteins CRABP-II, which delivers RA to RAR, and FABP5, which shuttles the hormone to PPARbeta/delta.	Tretinoin	25-38	fatty acid binding protein 5, epidermal	Mus musculus	213-218
23991366-1	2013	The vitamin A metabolite retinoic acid (RA) regulates gene transcription by activating the nuclear receptors RAR and PPARbeta/delta and their cognate lipid binding proteins CRABP-II, which delivers RA to RAR, and FABP5, which shuttles the hormone to PPARbeta/delta.	Tretinoin	40-42	fatty acid binding protein 5, epidermal	Mus musculus	213-218
22716252-6	2012	The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice.	Radium	61-63	fatty acid binding protein 5, epidermal	Mus musculus	92-97
22716252-6	2012	The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice.	Radium	61-63	fatty acid binding protein 5, epidermal	Mus musculus	133-138
21474828-1	2011	OBJECTIVE: The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis.	Fatty Acids	36-46	fatty acid binding protein 5, epidermal	Mus musculus	86-91
21474828-1	2011	OBJECTIVE: The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis.	Glucose	151-158	fatty acid binding protein 5, epidermal	Mus musculus	86-91
20238174-1	2010	Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport.	Fatty Acids, Nonesterified	76-92	fatty acid binding protein 5, epidermal	Mus musculus	0-28
20238174-1	2010	Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport.	Fatty Acids, Nonesterified	76-92	fatty acid binding protein 5, epidermal	Mus musculus	30-35
20600628-9	2010	RA is able to induce proliferation through non-classical and redox-dependent mechanisms accompanied by increased levels of FABP5 mRNA.	Tretinoin	0-2	fatty acid binding protein 5, epidermal	Mus musculus	123-128
23977003-3	2013	Endogenous all-trans retinoic acid (ATRA) can activate both receptors depending on specific transport proteins: Fabp5 initiates PPARdelta signaling whereas Crabp2 promotes RAR signaling.	Tretinoin	11-34	fatty acid binding protein 5, epidermal	Mus musculus	112-117
23977003-3	2013	Endogenous all-trans retinoic acid (ATRA) can activate both receptors depending on specific transport proteins: Fabp5 initiates PPARdelta signaling whereas Crabp2 promotes RAR signaling.	Tretinoin	36-40	fatty acid binding protein 5, epidermal	Mus musculus	112-117
23105114-1	2012	Retinoic acid (RA) regulates gene transcription by activating the nuclear receptors retinoic acid receptor (RAR) and peroxisome proliferator-activated receptor (PPAR) beta/delta and their respective cognate lipid-binding proteins CRABP-II and FABP5.	Tretinoin	0-13	fatty acid binding protein 5, epidermal	Mus musculus	243-248
23105114-1	2012	Retinoic acid (RA) regulates gene transcription by activating the nuclear receptors retinoic acid receptor (RAR) and peroxisome proliferator-activated receptor (PPAR) beta/delta and their respective cognate lipid-binding proteins CRABP-II and FABP5.	Tretinoin	15-17	fatty acid binding protein 5, epidermal	Mus musculus	243-248
23105114-3	2012	Here, we show that the RA-induced commitment of P19 stem cells to neuronal progenitors is mediated by the CRABP-II/RAR path and that the FABP5/PPARbeta/delta path can inhibit the process through induction of the RAR repressors SIRT1 and Ajuba.	Tretinoin	23-25	fatty acid binding protein 5, epidermal	Mus musculus	137-142
23105114-6	2012	The switch in RA signaling is accomplished by a transient up-regulation of RARbeta concomitantly with a transient increase in the CRABP-II/FABP5 ratio at early stages of differentiation.	Tretinoin	14-16	fatty acid binding protein 5, epidermal	Mus musculus	139-144
22585040-8	2012	The gene expression of interleukin (IL)-7 and IL-18 was increased both in FABP4 and FABP5 over-expressing cells compared with controls, and moreover, the increase in their expressions by adding of stearic acids was significantly enhanced in the FABP4 over-expressing cells.	Stearic Acids	197-210	fatty acid binding protein 5, epidermal	Mus musculus	84-89
19960455-7	2010	Hereby, we identified Q(10)H(2)-sensitive genes which are regulated by peroxisome proliferator-activated receptor-alpha and are primarily involved in cholesterol synthesis (e.g. HMGCS1, HMGCL and HMGCR), fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1).	Cholesterol	150-161	fatty acid binding protein 5, epidermal	Mus musculus	222-227
20042001-2	2010	Carrier proteins that move the RA from the cytosol into the nucleus are the fatty acid-binding protein 5 (FABP5), activating PPARdelta, and the cellular retinoic acid-binding protein II (CRABPII), activating RAR.	Tretinoin	31-33	fatty acid binding protein 5, epidermal	Mus musculus	76-104
20042001-2	2010	Carrier proteins that move the RA from the cytosol into the nucleus are the fatty acid-binding protein 5 (FABP5), activating PPARdelta, and the cellular retinoic acid-binding protein II (CRABPII), activating RAR.	Tretinoin	31-33	fatty acid binding protein 5, epidermal	Mus musculus	106-111
19494286-1	2009	Epidermal fatty acid-binding protein, E-FABP, a lipid chaperone, has been shown to regulate the inflammatory function of macrophages and dendritic cells.	Fatty Acids	10-20	fatty acid binding protein 5, epidermal	Mus musculus	38-44
19307565-8	2009	AEA uptake and hydrolysis were significantly potentiated in N18TG2 neuroblastoma cells after overexpression of FABP5 or FABP7, but not FABP3.	anandamide	0-3	fatty acid binding protein 5, epidermal	Mus musculus	111-116
18551191-3	2008	In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice.	Fatty Acids	101-111	fatty acid binding protein 5, epidermal	Mus musculus	159-164
18025090-5	2008	To determine the feasibility of using helper-dependent adenoviral vectors for expression of shRNA in liver, we have designed an shRNA construct to mouse fabp5 (fatty acid-binding protein 5).	Fatty Acids	160-170	fatty acid binding protein 5, epidermal	Mus musculus	153-158
13129924-6	2003	However, in the presence of 10 microm oleate, A-FABP and E-FABP each bound to HSL with high affinity (Kd of 0.5 and 3 nM, respectively) in a approximately 1:1 molar stoichiometry, whereas liver FABP and intestinal FABP did not exhibit any association.	Oleic Acid	38-44	fatty acid binding protein 5, epidermal	Mus musculus	57-63
15164767-1	2004	Based on the assumption that fatty-acid-binding proteins (FABPs) of the epidermal-type (E-FABP) and heart-type (H-FABP) in murine alveolar type II (TII) cells mediate the synthesis of dipalmitoyl phosphatidylcholine (DPPC), the main surfactant phospholipid, we analysed TII cells isolated from wild-type (wt) and E/H-FABP double-knockout (double-ko) mice.	Fatty Acids	29-39	fatty acid binding protein 5, epidermal	Mus musculus	88-94
15164767-8	2004	This indicated that E-FABP and/or H-FABP are involved in the mediation of DPPC synthesis in wt TII cells.	1,2-Dipalmitoylphosphatidylcholine	74-78	fatty acid binding protein 5, epidermal	Mus musculus	20-26
14614628-6	2003	Taken together, E-FABP is useful as a marker for dendritic cells in the splenic white pulp, and may be involved through combination with fatty acids in antigen presentation and retention as well as in cytokine production.	Fatty Acids	137-148	fatty acid binding protein 5, epidermal	Mus musculus	16-22
12540600-2	2003	The fatty acid binding proteins aP2 (fatty acid binding protein [FABP]-4) and mal1 (FABP5) are closely related and both are expressed in adipocytes.	Fatty Acids	4-14	fatty acid binding protein 5, epidermal	Mus musculus	84-89
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Tetradecanoylphorbol Acetate	0-3	fatty acid binding protein 5, epidermal	Mus musculus	126-131
12454272-7	2002	Herein, we report the construction of transgenic mice overexpressing the FABP5 gene encoding the epithelial fatty acid binding protein (E-FABP) in adipocytes, thereby allowing evaluation of the effects on lipolysis of increased FABP levels and of type specificity.	Fatty Acids	108-118	fatty acid binding protein 5, epidermal	Mus musculus	73-78
12454272-7	2002	Herein, we report the construction of transgenic mice overexpressing the FABP5 gene encoding the epithelial fatty acid binding protein (E-FABP) in adipocytes, thereby allowing evaluation of the effects on lipolysis of increased FABP levels and of type specificity.	Fatty Acids	108-118	fatty acid binding protein 5, epidermal	Mus musculus	136-142
12479572-6	2002	These results demonstrate that E-FABP is responsible for the water permeability barrier of the skin, although the molecular mechanism remains to be further elucidated.	Water	61-66	fatty acid binding protein 5, epidermal	Mus musculus	31-37
11874481-0	2002	Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice.	Water	8-13	fatty acid binding protein 5, epidermal	Mus musculus	34-75
11874481-7	2002	The molecular mechanism by which epidermal-type fatty acid binding protein contributes to the water barrier function of the skin remains to be elucidated.	Water	94-99	fatty acid binding protein 5, epidermal	Mus musculus	33-74
11819097-1	2002	The immunoreactivity for epidermal-type fatty acid binding protein of epidermis type (E-FABP) was selectively localized in the epithelial cells of both cortex and medulla of mouse thymus.	Fatty Acids	40-50	fatty acid binding protein 5, epidermal	Mus musculus	86-92
11819097-4	2002	Considering the possibility that FABPs function as intracellular carriers for unsaturated long chain fatty acids, the present finding suggests that E-FABP in the thymic epithelial cells, especially the cortical ones because of their extensive location, are intimately involved in the metabolic processes of fatty acids including production of bioactive substances, such as prostaglandin and leukotriene, which are known to exert some regulation of thymic immune responses.	unsaturated long chain fatty acids	78-112	fatty acid binding protein 5, epidermal	Mus musculus	148-154
11819097-4	2002	Considering the possibility that FABPs function as intracellular carriers for unsaturated long chain fatty acids, the present finding suggests that E-FABP in the thymic epithelial cells, especially the cortical ones because of their extensive location, are intimately involved in the metabolic processes of fatty acids including production of bioactive substances, such as prostaglandin and leukotriene, which are known to exert some regulation of thymic immune responses.	Fatty Acids	101-112	fatty acid binding protein 5, epidermal	Mus musculus	148-154
11819097-4	2002	Considering the possibility that FABPs function as intracellular carriers for unsaturated long chain fatty acids, the present finding suggests that E-FABP in the thymic epithelial cells, especially the cortical ones because of their extensive location, are intimately involved in the metabolic processes of fatty acids including production of bioactive substances, such as prostaglandin and leukotriene, which are known to exert some regulation of thymic immune responses.	Prostaglandins	373-386	fatty acid binding protein 5, epidermal	Mus musculus	148-154
11819097-4	2002	Considering the possibility that FABPs function as intracellular carriers for unsaturated long chain fatty acids, the present finding suggests that E-FABP in the thymic epithelial cells, especially the cortical ones because of their extensive location, are intimately involved in the metabolic processes of fatty acids including production of bioactive substances, such as prostaglandin and leukotriene, which are known to exert some regulation of thymic immune responses.	Leukotrienes	391-402	fatty acid binding protein 5, epidermal	Mus musculus	148-154
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Tetradecanoylphorbol Acetate	0-3	fatty acid binding protein 5, epidermal	Mus musculus	121-125
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Phorbol Esters	156-170	fatty acid binding protein 5, epidermal	Mus musculus	121-125
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Phorbol Esters	156-170	fatty acid binding protein 5, epidermal	Mus musculus	126-131
9795232-1	1998	The keratinocyte lipid-binding protein (KLBP) is a member of a large multigene family of intracellular fatty-acid-binding proteins.	Fatty Acids	103-113	fatty acid binding protein 5, epidermal	Mus musculus	4-38
9795232-1	1998	The keratinocyte lipid-binding protein (KLBP) is a member of a large multigene family of intracellular fatty-acid-binding proteins.	Fatty Acids	103-113	fatty acid binding protein 5, epidermal	Mus musculus	40-44
9795232-5	1998	Based on the highly conserved structure of the fatty-acid-binding protein genes, the third intron of the KLBP gene was PCR-amplified utilizing murine genomic DNA.	Fatty Acids	47-57	fatty acid binding protein 5, epidermal	Mus musculus	105-109
34942197-4	2021	While Nair, a common depilatory cream, removed hair by breaking down keratin disulfide bonds, it activated cytosolic phospholipase A2 (cPLA2), leading to activation of the arachidonic acid (AA)/E-FABP/PPARbeta signaling pathway in keratinocytes.	Arachidonic Acid	172-188	fatty acid binding protein 5, epidermal	Mus musculus	194-200
34449874-3	2022	Fatty acid-binding protein 5 (FABP5) is a cellular chaperone of long-chain fatty acids that induce biological responses.	long-chain fatty acids	64-86	fatty acid binding protein 5, epidermal	Mus musculus	0-28
34449874-3	2022	Fatty acid-binding protein 5 (FABP5) is a cellular chaperone of long-chain fatty acids that induce biological responses.	long-chain fatty acids	64-86	fatty acid binding protein 5, epidermal	Mus musculus	30-35
35526449-2	2022	Inhibiting two of the main FABP subtypes found in the brain (FABP5 and FABP7) hinders endocannabinoid uptake and hydrolysis.	Endocannabinoids	86-101	fatty acid binding protein 5, epidermal	Mus musculus	61-66
34400394-0	2021	Dietary fats high in linoleic acids impair anti-tumor T cell responses by inducing E-FABP-mediated mitochondrial dysfunction.	Linoleic Acids	21-35	fatty acid binding protein 5, epidermal	Mus musculus	83-89
34400394-10	2021	Collectively, these data suggest that dietary oils high in LA promote mammary tumors by inducing E-FABP-mediated T cell dysfunction.	Dietary Fats, Unsaturated	38-50	fatty acid binding protein 5, epidermal	Mus musculus	97-103
34876574-6	2021	S-glutathionylation of Cys127 in FABP5 promotes its fatty acid binding ability and nuclear translocation.	Fatty Acids	52-62	fatty acid binding protein 5, epidermal	Mus musculus	33-38
33994513-0	2021	FABP5 Is a Sensitive Marker for Lipid-Rich Macrophages in the Luminal Side of Atherosclerotic Lesions.	Phenobarbital	62-69	fatty acid binding protein 5, epidermal	Mus musculus	0-5
35195769-7	2022	E-FABP-immunopositive septoclasts were detected for the first time at the beginning of MC resorption and localized along the resorption surface.	Methylcholanthrene	87-89	fatty acid binding protein 5, epidermal	Mus musculus	0-6
35195769-11	2022	The present study showed that E-FABP-immunopositive septoclasts participated in the disappearance of MC through the resorption of the uncalcified cartilage matrix and that they have different roles from osteoclasts/chondroclasts.	Methylcholanthrene	101-103	fatty acid binding protein 5, epidermal	Mus musculus	30-36
33994513-7	2021	Oil red O (ORO) staining revealed that FABP5-positive cells were lipid-rich in early and advanced lesions.	oil red O	11-14	fatty acid binding protein 5, epidermal	Mus musculus	39-44
33994513-7	2021	Oil red O (ORO) staining revealed that FABP5-positive cells were lipid-rich in early and advanced lesions.	oil red O	0-9	fatty acid binding protein 5, epidermal	Mus musculus	39-44
33994513-11	2021	These findings, along with previous reports, suggest a novel notion that FABP5 is a sensitive marker for bone marrow-derived lipid-rich macrophages in the luminal side of atherosclerotic lesions, although its functional significance remains elusive.	Phenobarbital	155-162	fatty acid binding protein 5, epidermal	Mus musculus	73-78
31661167-11	2020	Treatment of mice with FABP5 inhibitors reduced tumor growth and a combination of FABP5 inhibitors with a submaximal dose of docetaxel reduced tumor growth to a larger extent than treatment with each drug alone.	Docetaxel	125-134	fatty acid binding protein 5, epidermal	Mus musculus	82-87
33929718-1	2021	Fatty acid-binding protein 5 (FABP5) is an important member of the FABP family and plays a vital role in the metabolism of fatty acids.	Fatty Acids	123-134	fatty acid binding protein 5, epidermal	Mus musculus	0-28
33929718-1	2021	Fatty acid-binding protein 5 (FABP5) is an important member of the FABP family and plays a vital role in the metabolism of fatty acids.	Fatty Acids	123-134	fatty acid binding protein 5, epidermal	Mus musculus	30-35
33929718-6	2021	In addition, transmission electron microscopy, ATP detection, and WB revealed that TAC caused severe impairment to mitochondria in the hearts of FABP5-deficient mice compared with that in control mice.	tac	83-86	fatty acid binding protein 5, epidermal	Mus musculus	145-150
33398436-5	2021	FABP4-positive septoclasts in FABP5-/- mice were more numerous than those cells in wild mice.Peroxisome proliferator-activated receptor (PPAR) gamma was expressed in FABP4-positive septoclasts of FABP5-/- mice as well as mice administered with GW1929, a PPARgamma agonist, suggesting that the occurrence of PPARgamma induces an increase of FABP4-positive septoclasts.	GW 1929	244-250	fatty acid binding protein 5, epidermal	Mus musculus	30-35
32979397-7	2020	We have tested blockers for several cannabinoid-metabolizing enzymes and transporters (FABP5 and membrane reuptake) for their ability to alter ocular pressure in a murine model of IOP.	Cannabinoids	36-47	fatty acid binding protein 5, epidermal	Mus musculus	87-92
33024217-5	2020	We sought to examine the role of FABP5 in the allergic lung inflammation and demonstrated that the expression of FABP5 acts as a novel positive regulator of ST2 expression in alveolar ECs to generate retinoic acid (RA) and supports the synthesis of RA from type II alveolar ECs to suppress excessive activation of innate lymphoid cell (ILC) 2 during allergic lung inflammation.	Tretinoin	200-213	fatty acid binding protein 5, epidermal	Mus musculus	113-118
32184719-13	2020	Specifically, silibinin reduced the expression of several key factors such as FABP5, Plin4, GPD1, and AGPTA2.	Silybin	14-23	fatty acid binding protein 5, epidermal	Mus musculus	78-83
31941087-0	2020	Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer.	5,6-epoxy-8,11,14-eicosatrienoic acid	25-50	fatty acid binding protein 5, epidermal	Mus musculus	68-73
31941087-5	2020	Furthermore, EET-associated nuclear translocation of FABP4 and FABP5 and nuclear accumulation of SREBP-2 or PPAR-gamma influence TNBC cell proliferation, migratory transformation, and distal metastasis priming.	5,6-epoxy-8,11,14-eicosatrienoic acid	13-16	fatty acid binding protein 5, epidermal	Mus musculus	63-68
33499263-0	2021	Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress.	Fatty Acids	10-20	fatty acid binding protein 5, epidermal	Mus musculus	40-45
33499263-4	2021	We further investigated whether epidermal fatty acid-binding protein 5 (FABP5) is related to alphaSyn oligomerization/aggregation and subsequent disturbances in mitochondrial function in neuronal cells.	Fatty Acids	42-52	fatty acid binding protein 5, epidermal	Mus musculus	72-77
33499263-5	2021	In the presence of rotenone, a mitochondrial respiratory chain complex I inhibitor, co-overexpression of FABP5 with alphaSyn significantly decreased the viability of Neuro-2A cells compared to that of alphaSyn alone.	Rotenone	19-27	fatty acid binding protein 5, epidermal	Mus musculus	105-110
32550890-10	2020	Furthermore, FABP5 promoted epithelial-mesenchymal transition, lymphangiogenesis, and LNM by reprogramming fatty acid (FA) metabolism.	Fatty Acids	107-117	fatty acid binding protein 5, epidermal	Mus musculus	13-18
32550890-11	2020	Mechanistically, FABP5 promoted lipolysis and FA synthesis, which led to an increase in intracellular fatty acids (FAs) that activated NF-kappaB signalling, thus inducing LNM.	Fatty Acids	102-113	fatty acid binding protein 5, epidermal	Mus musculus	17-22
32550890-13	2020	The pro-metastatic effect of FABP5 was reduced by miR-144-3p.	mir-144-3p	50-60	fatty acid binding protein 5, epidermal	Mus musculus	29-34
32550890-16	2020	Moreover, the expression and biological function of FABP5 can be regulated by miR-144-3p in hypoxia.	mir-144-3p	78-88	fatty acid binding protein 5, epidermal	Mus musculus	52-57
31944767-2	2020	We have demonstrated in an AD mouse model that this is associated with reduced blood-brain barrier (BBB) transport of DHA and lower expression of the key DHA-trafficking protein, fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	154-157	fatty acid binding protein 5, epidermal	Mus musculus	179-207
31944767-2	2020	We have demonstrated in an AD mouse model that this is associated with reduced blood-brain barrier (BBB) transport of DHA and lower expression of the key DHA-trafficking protein, fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	154-157	fatty acid binding protein 5, epidermal	Mus musculus	209-214
31944767-7	2020	Furthermore, treating male C57BL/6J mice with pioglitazone (40 mg/kg/day for 7 days) led to a 1.79-fold increase in BBB transport of 14C-DHA over 1 minute, using an in situ transcardiac perfusion technique, which was associated with a 1.82-fold increase in brain microvascular FABP5 expression.	pioglitazone	46-58	fatty acid binding protein 5, epidermal	Mus musculus	277-282
31944767-7	2020	Furthermore, treating male C57BL/6J mice with pioglitazone (40 mg/kg/day for 7 days) led to a 1.79-fold increase in BBB transport of 14C-DHA over 1 minute, using an in situ transcardiac perfusion technique, which was associated with a 1.82-fold increase in brain microvascular FABP5 expression.	Docosahexaenoic Acids	137-140	fatty acid binding protein 5, epidermal	Mus musculus	277-282
31661167-12	2020	CONCLUSIONS: FABP5 inhibitors increase the cytotoxic and tumor-suppressive effects of taxanes in PCa cells.	Taxoids	86-93	fatty acid binding protein 5, epidermal	Mus musculus	13-18
30386187-8	2018	Drastically increased protein species were identified as fatty acid binding protein FABP5, ferritin and calumenin.	Fatty Acids	57-67	fatty acid binding protein 5, epidermal	Mus musculus	84-89
31384535-6	2019	Silibinin significantly activated CFLAR and inhibited the phosphorylation of JNK, up-regulated the mRNA expression of Pparalpha, Fabp5, Cpt1alpha, Acox, Scd-1, Gpat and Mttp, reduced the activities of serum ALT and AST and the contents of hepatic TG, TC and MDA, increased the expression of NRF2 and the activities of CAT, GSH-Px and HO-1, and decreased the activities and expression of CYP2E1 and CYP4A in vivo.	Silybin	0-9	fatty acid binding protein 5, epidermal	Mus musculus	129-134
30866899-3	2019	In mice deficient for FABP4 and FABP5 (double knockout (DKO) mice), FA utilization by red skeletal muscle and the heart is markedly reduced by the impairment of trans-endothelial FA transport, with an increase in glucose use to compensate for reduced FA uptake even during fasting.	Glucose	213-220	fatty acid binding protein 5, epidermal	Mus musculus	32-37
30884482-5	2019	FABP5-deficient mouse bone marrow-derived macrophages produced higher levels of nitrite anion than their WT counterparts in response to various stimuli.	Nitrogen Dioxide	80-93	fatty acid binding protein 5, epidermal	Mus musculus	0-5
29559340-6	2018	12-O-tetradecanolyphorbol-13-acetate functioning as a tumor promoter induced E-FABP expression and initiated extensive flaring inflammation in skin.	12-o-tetradecanolyphorbol-13-acetate	0-36	fatty acid binding protein 5, epidermal	Mus musculus	77-83
29559340-7	2018	Interestingly, 12-O-tetradecanolyphorbol-13-acetate -induced production of IFN-beta and IFN-lambda in the skin tissue was dependent on E-FABP expression.	12-o-tetradecanolyphorbol-13-acetate	15-51	fatty acid binding protein 5, epidermal	Mus musculus	135-141
29570114-4	2018	In experiment 2, male and female FABP5/7 deficient mice showed significant increases in sucrose consumption (25 and 21%, respectively) compared with their WT counterparts.	Sucrose	88-95	fatty acid binding protein 5, epidermal	Mus musculus	33-38
29582413-0	2018	Dietary docosahexaenoic acid supplementation enhances expression of fatty acid-binding protein 5 at the blood-brain barrier and brain docosahexaenoic acid levels.	Docosahexaenoic Acids	8-28	fatty acid binding protein 5, epidermal	Mus musculus	68-96
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	31-51	fatty acid binding protein 5, epidermal	Mus musculus	148-176
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	31-51	fatty acid binding protein 5, epidermal	Mus musculus	178-183
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	53-56	fatty acid binding protein 5, epidermal	Mus musculus	148-176
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	53-56	fatty acid binding protein 5, epidermal	Mus musculus	178-183
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Fatty Acids	84-94	fatty acid binding protein 5, epidermal	Mus musculus	148-176
29582413-1	2018	The cytoplasmic trafficking of docosahexaenoic acid (DHA), a cognitively beneficial fatty acid, across the blood-brain barrier (BBB) is governed by fatty acid-binding protein 5 (FABP5).	Fatty Acids	84-94	fatty acid binding protein 5, epidermal	Mus musculus	178-183
29582413-2	2018	Lower levels of brain DHA have been observed in Alzheimer"s disease (AD), which is associated with diminished BBB expression of FABP5.	Docosahexaenoic Acids	22-25	fatty acid binding protein 5, epidermal	Mus musculus	128-133
29582413-3	2018	Therefore, up-regulating FABP5 expression at the BBB may be a novel approach for enhancing BBB transport of DHA in AD.	Docosahexaenoic Acids	108-111	fatty acid binding protein 5, epidermal	Mus musculus	25-30
29582413-4	2018	DHA supplementation has been shown to be beneficial in various mouse models of AD, and therefore, the aim of this study was to determine whether DHA has the potential to up-regulate the BBB expression of FABP5, thereby enhancing its own uptake into the brain.	Docosahexaenoic Acids	145-148	fatty acid binding protein 5, epidermal	Mus musculus	204-209
29582413-8	2018	Brain microvascular FABP5 protein expression was up-regulated 1.7-fold in mice fed the DHA-enriched diet, and this was associated with increased brain DHA levels (1.3-fold).	Docosahexaenoic Acids	87-90	fatty acid binding protein 5, epidermal	Mus musculus	20-25
29582413-8	2018	Brain microvascular FABP5 protein expression was up-regulated 1.7-fold in mice fed the DHA-enriched diet, and this was associated with increased brain DHA levels (1.3-fold).	Docosahexaenoic Acids	151-154	fatty acid binding protein 5, epidermal	Mus musculus	20-25
29582413-9	2018	Despite an increase in brain DHA levels, reduced BBB transport of 14 C-DHA was observed over a 1 min perfusion, possibly as a result of competitive binding to FABP5 between dietary DHA and 14 C-DHA.	Docosahexaenoic Acids	71-74	fatty acid binding protein 5, epidermal	Mus musculus	159-164
29582413-9	2018	Despite an increase in brain DHA levels, reduced BBB transport of 14 C-DHA was observed over a 1 min perfusion, possibly as a result of competitive binding to FABP5 between dietary DHA and 14 C-DHA.	Docosahexaenoic Acids	71-74	fatty acid binding protein 5, epidermal	Mus musculus	159-164
29582413-9	2018	Despite an increase in brain DHA levels, reduced BBB transport of 14 C-DHA was observed over a 1 min perfusion, possibly as a result of competitive binding to FABP5 between dietary DHA and 14 C-DHA.	Docosahexaenoic Acids	71-74	fatty acid binding protein 5, epidermal	Mus musculus	159-164
29582413-10	2018	This study has demonstrated that DHA can increase BBB expression of FABP5, as well as fatty acid transporters, overall increasing brain DHA levels.	Docosahexaenoic Acids	33-36	fatty acid binding protein 5, epidermal	Mus musculus	68-73
29582413-10	2018	This study has demonstrated that DHA can increase BBB expression of FABP5, as well as fatty acid transporters, overall increasing brain DHA levels.	Docosahexaenoic Acids	136-139	fatty acid binding protein 5, epidermal	Mus musculus	68-73
28500502-3	2017	On the other hand, retinoic acid (RA) can bind to E-FABP and is stored abundantly in the GP cartilage.	Tretinoin	19-32	fatty acid binding protein 5, epidermal	Mus musculus	50-56
29457656-4	2018	This study examined the effects of genetic deletion of FABP 5/7 on cocaine preference, as assessed by the Conditioned Place Preference (CPP) paradigm.	Cocaine	67-74	fatty acid binding protein 5, epidermal	Mus musculus	55-61
29457656-5	2018	Male and female wild type (WT) and FABP 5/7 KO mice showed similar acquisition of cocaine CPP, with no differences found in overall locomotor activity.	Cocaine	82-89	fatty acid binding protein 5, epidermal	Mus musculus	35-41
29457656-9	2018	Male and female FABP 5/7 KO mice showed reduced corticosterone levels under stress compared to their WT counterparts.	Corticosterone	48-62	fatty acid binding protein 5, epidermal	Mus musculus	16-22
29457656-10	2018	The reduction in corticosterone response under stress may mediate that lack of a stress-induced preference for cocaine in the FABP 5/7 KO mice.	Corticosterone	17-31	fatty acid binding protein 5, epidermal	Mus musculus	126-132
29626089-5	2018	More importantly, cytosolic expression of epidermal FA binding protein (E-FABP) in monocytes/macrophages was shown to be critical to the mediation of the SA-induced effect.	stearic acid	154-156	fatty acid binding protein 5, epidermal	Mus musculus	42-70
29626089-5	2018	More importantly, cytosolic expression of epidermal FA binding protein (E-FABP) in monocytes/macrophages was shown to be critical to the mediation of the SA-induced effect.	stearic acid	154-156	fatty acid binding protein 5, epidermal	Mus musculus	72-78
29626089-6	2018	Depletion of E-FABP not only inhibited SA-induced CD11c upregulation in macrophages in vitro but also abrogated high-saturated-fat diet-induced skin lesions in obese mouse models in vivo.	stearic acid	39-41	fatty acid binding protein 5, epidermal	Mus musculus	13-19
29626089-6	2018	Depletion of E-FABP not only inhibited SA-induced CD11c upregulation in macrophages in vitro but also abrogated high-saturated-fat diet-induced skin lesions in obese mouse models in vivo.	saturated	117-126	fatty acid binding protein 5, epidermal	Mus musculus	13-19
29626089-7	2018	Altogether, our data demonstrate a novel mechanism by which saturated FAs promote obesity-associated inflammation through inducing E-FABP/retinoid acid receptor-mediated differentiation of CD11c+ macrophages.	Fatty Acids	70-73	fatty acid binding protein 5, epidermal	Mus musculus	131-137
29440395-5	2018	Inhibition of FABP5 reduced pain, edema, cytokine, and PGE2 levels.	Dinoprostone	55-59	fatty acid binding protein 5, epidermal	Mus musculus	14-19
29440395-6	2018	PGE2 is a major eicosanoid that enhances pain in the setting of inflammation, and we focused on the mechanism(s) through which FABP5 modulates PGE2 production.	Dinoprostone	143-147	fatty acid binding protein 5, epidermal	Mus musculus	127-132
29440395-8	2018	Pharmacological or genetic FABP5 inhibition suppressed the induction of mPGES-1 but not COX-2 in carrageenan-injected paws, which occurred predominantly in macrophages.	Carrageenan	97-108	fatty acid binding protein 5, epidermal	Mus musculus	27-32
29440395-14	2018	Collectively, these results position FABP5 as a novel regulator of mPGES-1 induction and PGE2 biosynthesis during inflammation.	Dinoprostone	89-93	fatty acid binding protein 5, epidermal	Mus musculus	37-42
29105065-0	2018	Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets.	Fatty Acids, Omega-3	161-179	fatty acid binding protein 5, epidermal	Mus musculus	42-70
29105065-2	2018	Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	6-9	fatty acid binding protein 5, epidermal	Mus musculus	122-150
29105065-2	2018	Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	6-9	fatty acid binding protein 5, epidermal	Mus musculus	152-157
29105065-2	2018	Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	92-95	fatty acid binding protein 5, epidermal	Mus musculus	122-150
29105065-2	2018	Brain DHA levels are regulated by the blood-brain barrier (BBB) transport of plasma-derived DHA, a process facilitated by fatty acid-binding protein 5 (FABP5).	Docosahexaenoic Acids	92-95	fatty acid binding protein 5, epidermal	Mus musculus	152-157
29105065-6	2018	This study demonstrates FABP5 deficiency and impaired DHA transport at the BBB are associated with increased vulnerability to cognitive deficits in mice fed an n-3 fatty acid-depleted diet, in line with our previous studies demonstrating a crucial role of FABP5 in BBB transport of DHA and cognitive function.	Fatty Acids	164-174	fatty acid binding protein 5, epidermal	Mus musculus	24-29
28500502-3	2017	On the other hand, retinoic acid (RA) can bind to E-FABP and is stored abundantly in the GP cartilage.	Tretinoin	34-36	fatty acid binding protein 5, epidermal	Mus musculus	50-56
28632393-2	2017	SBFI-26 is an alpha-truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effects in mice.	sodium-binding benzofuran isophthalate	0-4	fatty acid binding protein 5, epidermal	Mus musculus	102-107
28632393-2	2017	SBFI-26 is an alpha-truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effects in mice.	alpha-truxillic acid 1-naphthyl	14-45	fatty acid binding protein 5, epidermal	Mus musculus	102-107
28505074-7	2017	PCR array showed upregulation of some genes involved in lipid metabolism and anti-inflammatory activity (Cpt2, Ifng) and downregulation of some genes involved in pro-inflammatory response and in free fatty acid up-take (Fabp5, Socs3).	Fatty Acids, Nonesterified	195-210	fatty acid binding protein 5, epidermal	Mus musculus	220-225
28477305-11	2017	Obestatin influenced the expression of genes involved in lipid and carbohydrate metabolism by increasing Fabp5 and decreasing G6pc, Pepck, Fgf21 mRNA in the liver.	Ghrelin	0-9	fatty acid binding protein 5, epidermal	Mus musculus	105-110
28178326-9	2017	FGF19 treatment decreased the expression of proteins involved in fatty acid (FA) synthesis, i.e., Fabp5, Scd1, and Acsl3 and increased the expression of Acox1, involved in FA oxidation.	Fatty Acids	65-75	fatty acid binding protein 5, epidermal	Mus musculus	98-103
28415688-4	2017	Treatments have been established in mice by suppressing the biological activity of FABP5 using a chemical inhibitor SBFI26.	1-naphthyl alpha-truxillate	116-122	fatty acid binding protein 5, epidermal	Mus musculus	83-88