PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34861207-8 2022 Interestingly, we also observed that IP3R might dissociate from beclin-1 to motivate autophagy under the cisplatin insult. Cisplatin 105-114 beclin 1, autophagy related Mus musculus 64-72 33973685-7 2021 Furthermore, in vivo lentiviral-mediated knockdown of Beclin 1 in the myocardium ameliorated the I/R-induced impairment of autophagic flux and was associated with a reduction in cell death, whereas treatment with a lentivirus encoding Beclin 1 abolished the cardioprotective effect of TAC preconditioning. tac 285-288 beclin 1, autophagy related Mus musculus 54-62 33811924-8 2021 Beclin1, LC3, and Atg5 mRNA and protein expression levels in mice in the D.gal+17beta-E2 group were significantly increased compared with those in the D.gal group. Estradiol 86-88 beclin 1, autophagy related Mus musculus 0-7 30232271-5 2018 Mice heterozygous for Beclin-1 (Becn1+/-) were protected from the development of kidney tissue injury and renal fibrosis in response to CS exposure, and displayed impaired basal and inducible mitochondrial turnover by mitophagy. Cesium 136-138 beclin 1, autophagy related Mus musculus 22-30 30232271-5 2018 Mice heterozygous for Beclin-1 (Becn1+/-) were protected from the development of kidney tissue injury and renal fibrosis in response to CS exposure, and displayed impaired basal and inducible mitochondrial turnover by mitophagy. Cesium 136-138 beclin 1, autophagy related Mus musculus 32-37 30232271-6 2018 Interestingly, CS caused a reduction of Beclin-1 expression in mouse kidneys and kidney tubular epithelial cells, attributed to increased autophagy-dependent turnover of Beclin-1. Cesium 15-17 beclin 1, autophagy related Mus musculus 40-48 30232271-6 2018 Interestingly, CS caused a reduction of Beclin-1 expression in mouse kidneys and kidney tubular epithelial cells, attributed to increased autophagy-dependent turnover of Beclin-1. Cesium 15-17 beclin 1, autophagy related Mus musculus 170-178 30232271-7 2018 These results suggest that Beclin-1 is required for CS-induced kidney injury and that reduced levels of Beclin-1 may confer renoprotection. Cesium 52-54 beclin 1, autophagy related Mus musculus 27-35 34592338-15 2022 AFE also efficiently regressed CT26-derived solid tumor in Balb/c mice acting alone or in synergy with 5FU through inducing autophagy as a major mechanism of action as indicated by upregulation of Beclin 1 and phospho-AMPK, and inhibition of phosphor-S6K1 levels in the tumor tissue lysates. Fluorouracil 103-106 beclin 1, autophagy related Mus musculus 197-205 34782612-6 2021 We found that induction of autophagy by rapamycin is detrimental for neurons; whereas downregulation of Beclin1, an important autophagy inducing protein, provides significant protection in Abeta treated neuronal cells by blocking cytochrome-c release from the mitochondria. UNII-042A8N37WH 189-194 beclin 1, autophagy related Mus musculus 104-111 34929507-3 2022 In this study, both adult beclin 1+/+ and beclin 1+/- mice were employed to establish a model of chronic arsenite exposure by treating with arsenite via drinking water for 6 months. arsenite 140-148 beclin 1, autophagy related Mus musculus 26-34 34929507-5 2022 Heterozygous disruption of beclin 1 in animals remarkably alleviated the neurotoxic effects of arsenite. arsenite 95-103 beclin 1, autophagy related Mus musculus 27-35 34952420-17 2022 We also found that the expression of p-mTOR, P62, and Beclin1 was significantly increased and that LC3II/LC3I declined after LPS stimulation, but the effect was inhibited by treatment with GYY4137, indicating that GYY4137 could inhibit the activation of autophagy in sepsis-induced ALI by blocking mTOR signaling. GYY 4137 189-196 beclin 1, autophagy related Mus musculus 54-61 34952420-17 2022 We also found that the expression of p-mTOR, P62, and Beclin1 was significantly increased and that LC3II/LC3I declined after LPS stimulation, but the effect was inhibited by treatment with GYY4137, indicating that GYY4137 could inhibit the activation of autophagy in sepsis-induced ALI by blocking mTOR signaling. GYY 4137 214-221 beclin 1, autophagy related Mus musculus 54-61 34943057-1 2021 The run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. NADP 123-166 beclin 1, autophagy related Mus musculus 40-47 34943057-1 2021 The run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. NADP 168-173 beclin 1, autophagy related Mus musculus 40-47 34943057-1 2021 The run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. Reactive Oxygen Species 240-263 beclin 1, autophagy related Mus musculus 40-47 34943057-1 2021 The run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. Reactive Oxygen Species 265-268 beclin 1, autophagy related Mus musculus 40-47 34525858-4 2021 Interestingly, D4F facilitated gly-HDL-triggered activation of autophagy, measured as elevated levels of beclin-1, LC3-II, and ATG5 expressions in macrophages. Glycine 31-34 beclin 1, autophagy related Mus musculus 105-113 34525858-5 2021 Furthermore, the inhibition effect of D4F on gly-HDL-induced ER stress-CHOP-induced apoptosis of macrophages was restrained after beclin-1 siRNA and 3-methyladenine (3-MA, an inhibitor of autophagy) treatments, while this effect was further reinforced after rapamycin (Rapa, an inducer of autophagy) treatment. Glycine 45-48 beclin 1, autophagy related Mus musculus 130-138 34569336-9 2021 Moreover, ACR exposure increased LC3-positive signals, early apoptosis rate, aberrant ATG3, ATG5, LC3, Beclin1, and mTOR mRNA expression. Acrylamide 10-13 beclin 1, autophagy related Mus musculus 103-110 34796763-10 2021 The regulation of Beclin1 participated in the effects of DAPK1 on inflammation of arterial aneurysm by ATP-dependent NLRP3 inflammasome. Adenosine Triphosphate 103-106 beclin 1, autophagy related Mus musculus 18-25 34663513-8 2021 Meanwhile, NITyr upregulated the expression levels of LC3-II and Beclin-1, which were weakened by AM630 (an antagonist of CB2 receptor and a weak partial agonist of CB1 receptors). nityr 11-16 beclin 1, autophagy related Mus musculus 65-73 34663513-8 2021 Meanwhile, NITyr upregulated the expression levels of LC3-II and Beclin-1, which were weakened by AM630 (an antagonist of CB2 receptor and a weak partial agonist of CB1 receptors). iodopravadoline 98-103 beclin 1, autophagy related Mus musculus 65-73 34624429-8 2021 Alarin reduced the Ang II-induced increases of LC3, Beclin 1, autophagy-related gene (Atg)3 and Atg5 in NRCMs. alarin 0-6 beclin 1, autophagy related Mus musculus 52-60 34887935-11 2021 In addition, QFG treatment inhibited EMT and induced autophagy progression in CRC tumor cells, including that QFG upregulated the expression of E-cadherin, beclin-1, and LC3-II, but downregulated the expression of N-cadherin, vimentin, TWIST1, and p62. qfg 13-16 beclin 1, autophagy related Mus musculus 156-164 34887935-11 2021 In addition, QFG treatment inhibited EMT and induced autophagy progression in CRC tumor cells, including that QFG upregulated the expression of E-cadherin, beclin-1, and LC3-II, but downregulated the expression of N-cadherin, vimentin, TWIST1, and p62. qfg 110-113 beclin 1, autophagy related Mus musculus 156-164 34669944-10 2021 Autophagosomes, autophagolysosomes, and up-regulation of autophagy-related protein LC3II, Beclin1, Pink1, and Parkin were found in the selenium-deficient trophoblasts. Selenium 135-143 beclin 1, autophagy related Mus musculus 90-97 34253875-8 2022 Wogonin reversed HG-suppressed autophagy in MPC5 cells, evidenced by increased ATG7, LC3-II, and Beclin-1 protein, and decreased p62 protein. wogonin 0-7 beclin 1, autophagy related Mus musculus 97-105 34253875-8 2022 Wogonin reversed HG-suppressed autophagy in MPC5 cells, evidenced by increased ATG7, LC3-II, and Beclin-1 protein, and decreased p62 protein. Mercury 17-19 beclin 1, autophagy related Mus musculus 97-105 34928817-11 2021 The activation of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group consistent with decreased P62, Beclin1, LC-3A/B and SIRT1, and NAD+ reversed these results, furthermore SIRT1 inhibitor: SIRT-IN3 weakened the NAD+" effects in both in vivo and in vitro experiments. sirt-in3 198-206 beclin 1, autophagy related Mus musculus 108-115 34487425-5 2021 LC3-II/LC3-I, Beclin-1, IL-6, and IL-1beta protein expression in the bladder smooth muscle tissues of ketamine-treated mice was significantly increased. Ketamine 102-110 beclin 1, autophagy related Mus musculus 14-22 34815688-13 2021 rmIL-33 led to elevated expressions of Atg5, Beclin-1 and inhibited expression of p62 in expansion of Treg. rmil 0-4 beclin 1, autophagy related Mus musculus 45-53 34741242-0 2021 Different Roles of Beclin1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein. Morphine 89-97 beclin 1, autophagy related Mus musculus 19-26 34741242-1 2021 Previously we showed that Beclin1 has a regulatory role in the secretion of inflammatory molecules in glia after exposure to morphine and Tat (an HIV protein). Morphine 125-133 beclin 1, autophagy related Mus musculus 26-33 34741242-1 2021 Previously we showed that Beclin1 has a regulatory role in the secretion of inflammatory molecules in glia after exposure to morphine and Tat (an HIV protein). Triethylenemelamine 138-141 beclin 1, autophagy related Mus musculus 26-33 34741242-5 2021 After morphine implantation, significantly impaired locomotor activities were detected in both Becn1+/+ and Becn1+/- mice, irrespective of Tat infusion. Morphine 6-14 beclin 1, autophagy related Mus musculus 95-100 34741242-5 2021 After morphine implantation, significantly impaired locomotor activities were detected in both Becn1+/+ and Becn1+/- mice, irrespective of Tat infusion. Morphine 6-14 beclin 1, autophagy related Mus musculus 108-113 34741242-7 2021 Interestingly, co-exposure to morphine and Tat increased sensitivity to pain in Becn1+/+ mice, but not in similarly treated Becn1+/- mice. Morphine 30-38 beclin 1, autophagy related Mus musculus 80-85 34741242-7 2021 Interestingly, co-exposure to morphine and Tat increased sensitivity to pain in Becn1+/+ mice, but not in similarly treated Becn1+/- mice. Triethylenemelamine 43-46 beclin 1, autophagy related Mus musculus 80-85 34741242-8 2021 Brain homogenates from Becn1+/+ mice exposed to Tat, alone and in combination with morphine, showed increased secretion of pro-inflammatory cytokines and reduced expression of growth factors when compared to similarly treated Becn1+/- mice. Triethylenemelamine 48-51 beclin 1, autophagy related Mus musculus 23-28 34741242-8 2021 Brain homogenates from Becn1+/+ mice exposed to Tat, alone and in combination with morphine, showed increased secretion of pro-inflammatory cytokines and reduced expression of growth factors when compared to similarly treated Becn1+/- mice. Morphine 83-91 beclin 1, autophagy related Mus musculus 23-28 34741242-9 2021 Likewise, increased neuronal loss was detected when both Tat and morphine were administered to Becn1+/+ mice, but not in similarly treated Becn1+/- mice. Triethylenemelamine 57-60 beclin 1, autophagy related Mus musculus 95-100 34741242-9 2021 Likewise, increased neuronal loss was detected when both Tat and morphine were administered to Becn1+/+ mice, but not in similarly treated Becn1+/- mice. Morphine 65-73 beclin 1, autophagy related Mus musculus 95-100 34741242-10 2021 Overall, our findings show that there is a Beclin1-driven interaction between Tat and morphine in glia and neurons. Triethylenemelamine 78-81 beclin 1, autophagy related Mus musculus 43-50 34741242-10 2021 Overall, our findings show that there is a Beclin1-driven interaction between Tat and morphine in glia and neurons. Morphine 86-94 beclin 1, autophagy related Mus musculus 43-50 34741242-11 2021 Moreover, reduced glial-Beclin1 may provide a layer of protection to neurons under stressful conditions, such as when exposed to morphine and Tat. Morphine 129-137 beclin 1, autophagy related Mus musculus 24-31 34741242-11 2021 Moreover, reduced glial-Beclin1 may provide a layer of protection to neurons under stressful conditions, such as when exposed to morphine and Tat. Triethylenemelamine 142-145 beclin 1, autophagy related Mus musculus 24-31 34536393-9 2021 The mRNA and protein levels of autophagy-related genes LC3, Beclin1 and p62 were significantly changed after NaF treatment. Sodium Fluoride 109-112 beclin 1, autophagy related Mus musculus 60-67 34353430-7 2021 KHG26700 also suppressed the LPS-induced increases in protein levels of autophagy protein 5 (ATG5), microtubule- associated protein 1 light chain 3 (LC3), and beclin-1, as well as downregulating the LPS-enhanced levels of ROS, lipid peroxidation, and nitric oxide. khg26700 0-8 beclin 1, autophagy related Mus musculus 159-167 34146870-7 2021 The results on the mechanisms of liver toxicity indicated that butachlor induced overexpression of Apaf-1, Bax, Caspase-3, Caspase-9, Cyt-c, p53, Beclin-1, ATG-5, and LC3, whereas decreases the expression of Bcl-2 and p62 suggesting abnormal processes of apoptosis and autophagy. butachlor 63-72 beclin 1, autophagy related Mus musculus 146-154 34371252-14 2021 Furthermore, the changes of autophagy and apoptosis markers, such as LC3II, Beclin1, p62, Bcl-2, Bax and Cleaved-caspase-3 induced by ISO were resumed by PASE treatment. Isoproterenol 134-137 beclin 1, autophagy related Mus musculus 76-83 34438345-6 2021 Additionally, ISO triggered marked ferritinophagy accompanied by up-regulating protein levels of LC3BII,NCOA4 and Beclin1 and down-regulating protein levels of P62 and FTH1 in damaged cells, which nevertheless was significantly blocked by administration of ATV and these results were in parallel with the results obtained after 3-methyadenine(3-MA) treatment. iso 14-17 beclin 1, autophagy related Mus musculus 114-121 34438345-6 2021 Additionally, ISO triggered marked ferritinophagy accompanied by up-regulating protein levels of LC3BII,NCOA4 and Beclin1 and down-regulating protein levels of P62 and FTH1 in damaged cells, which nevertheless was significantly blocked by administration of ATV and these results were in parallel with the results obtained after 3-methyadenine(3-MA) treatment. Atazanavir Sulfate 257-260 beclin 1, autophagy related Mus musculus 114-121 34644772-7 2021 RESULTS: The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress. Hydrogen 31-39 beclin 1, autophagy related Mus musculus 200-208 34644772-7 2021 RESULTS: The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress. Sodium Chloride 45-51 beclin 1, autophagy related Mus musculus 200-208 34243113-0 2021 HMGB1 could restrict 1,3-beta-glucan induced mice lung inflammation by affecting Beclin1 and Bcl2 interaction and promoting the autophagy of epithelial cells. beta-1,3-glucan 21-36 beclin 1, autophagy related Mus musculus 81-88 34243113-9 2021 And ubiquitination of Beclin1 contributed to decreasing the interaction of Beclin1 and Bcl2, which might be a key regulatory mechanism of HMGB1 on 1,3-beta-glucan induced autophagy. beta-1,3-glucan 147-162 beclin 1, autophagy related Mus musculus 22-29 34243113-9 2021 And ubiquitination of Beclin1 contributed to decreasing the interaction of Beclin1 and Bcl2, which might be a key regulatory mechanism of HMGB1 on 1,3-beta-glucan induced autophagy. beta-1,3-glucan 147-162 beclin 1, autophagy related Mus musculus 75-82 34371252-14 2021 Furthermore, the changes of autophagy and apoptosis markers, such as LC3II, Beclin1, p62, Bcl-2, Bax and Cleaved-caspase-3 induced by ISO were resumed by PASE treatment. pase 154-158 beclin 1, autophagy related Mus musculus 76-83 34545064-7 2021 Further in vitro studies showed that autophagy was inhibited in N2A cells treated with 1-methyl-4-phenylpyridinium (MPP+), as reflected by a significant decrease in the expressions of autophagy marker proteins (Beclin1 and LC3II) and an increase in the expression of autophagic flux marker p62. 1-Methyl-4-phenylpyridinium 87-114 beclin 1, autophagy related Mus musculus 211-218 34604389-0 2021 Influence of miRNA-30a-5p on Pulmonary Fibrosis in Mice with Streptococcus pneumoniae Infection through Regulation of Autophagy by Beclin-1. mirna-30a-5p 13-25 beclin 1, autophagy related Mus musculus 131-139 34545064-7 2021 Further in vitro studies showed that autophagy was inhibited in N2A cells treated with 1-methyl-4-phenylpyridinium (MPP+), as reflected by a significant decrease in the expressions of autophagy marker proteins (Beclin1 and LC3II) and an increase in the expression of autophagic flux marker p62. mangion-purified polysaccharide (Candida albicans) 116-120 beclin 1, autophagy related Mus musculus 211-218 34278508-7 2021 The results showed that DEX treatment markedly increased the survival rate and neurological score, increased neuron survival, decreased the expression of the LC3, Beclin-1 and NF-kappaB proteins, as well as the cytokines IL-1beta, IL-6 and TNF-alpha, which indicated that DEX-mediated inhibition of autophagy and neuroinflammation ameliorated neuronal death following TBI. Dexmedetomidine 24-27 beclin 1, autophagy related Mus musculus 163-171 34060628-11 2021 Furthermore, the enhanced lipolysis by spermidine was also independent of autophagy in adipose tissue, given that adipose-specific autophagy deficient (Beclin-1 flox/+ Fabp4-cre) mice remained spermidine-responsive under HFD. Spermidine 39-49 beclin 1, autophagy related Mus musculus 152-160 34314818-8 2021 In B16F10 cells, EAA-induced autophagy was shown by enhanced LC3-II levels, AVO formation, Beclin-1 upregulation, and activation of p62/SQSTM1. 3-O-ethylascorbic acid 17-20 beclin 1, autophagy related Mus musculus 91-99 34251272-9 2021 Tat-beclin 1 peptide, a specific autophagy activator, could partially prevent IFT88-associated cell death during cisplatin treatment, although cilium length was not improved significantly. Cisplatin 113-122 beclin 1, autophagy related Mus musculus 4-12 34278508-7 2021 The results showed that DEX treatment markedly increased the survival rate and neurological score, increased neuron survival, decreased the expression of the LC3, Beclin-1 and NF-kappaB proteins, as well as the cytokines IL-1beta, IL-6 and TNF-alpha, which indicated that DEX-mediated inhibition of autophagy and neuroinflammation ameliorated neuronal death following TBI. Dexmedetomidine 272-275 beclin 1, autophagy related Mus musculus 163-171 34453960-8 2021 Exposure to phenanthrene induced an increase in the levels of ROS and a decrease in levels of glutathione, and caused a significant decrease in the expression of Shank3 and Beclin1. phenanthrene 12-24 beclin 1, autophagy related Mus musculus 173-180 34448959-8 2021 The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. 4,4'-{propane-1,3-diylbis[oxy(5-methoxy-1-benzothiene-6,2-diyl)]}bis(4-oxobutanoic acid) 72-75 beclin 1, autophagy related Mus musculus 4-12 34448959-8 2021 The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. 4,4'-{propane-1,3-diylbis[oxy(5-methoxy-1-benzothiene-6,2-diyl)]}bis(4-oxobutanoic acid) 72-75 beclin 1, autophagy related Mus musculus 14-19 34466017-8 2021 The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group. Vitamin D 98-107 beclin 1, autophagy related Mus musculus 38-46 34466017-8 2021 The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group. Vitamin D 165-174 beclin 1, autophagy related Mus musculus 38-46 34466017-10 2021 In vitro, 1,25(OH)2D3 also regulated the expression of LC3, Beclin-1, ATG5, and NF-kappaB p65 mRNA in AMs in a time- and dose-dependent manner. Calcitriol 10-21 beclin 1, autophagy related Mus musculus 60-68 34462635-8 2021 Lastly, we showed that taxifolin suppressed tumors in mice; stimulated expression of autophagy-related genes LC3B-II, Atg7, atg12, and Beclin-1; and inhibited expression of fatty acid synthesis-related genes C/EBPalpha, PPARgamma, FABP4, and FAS. taxifolin 23-32 beclin 1, autophagy related Mus musculus 135-143 34211859-7 2021 Activation of Beclin-1 by forced expression of active mutant Becn1F121A or by treatment with TB-peptide enhanced autophagy and significantly reduced sickness scores, systemic infection, and circulating and pulmonary cytokine production. tb-peptide 93-103 beclin 1, autophagy related Mus musculus 14-22 34281243-9 2021 The autophagy process was modulated by BPA, through elevated autophagy-related gene 5 (Atg5), autophagy-related gene 7 (Atg7), Microtubule-associated proteins 1A/1B light chain 3B (Map1lc3b/Lc3b) and Beclin-1 gene levels and blockaded the autophagosome maturation and flux (p62 levels). bisphenol A 39-42 beclin 1, autophagy related Mus musculus 200-208 34422996-10 2021 Treatment with oridonin also led to an increase in the quantity of LC3B II protein and upregulation of the p62 and Beclin-1 levels in PC cells. oridonin 15-23 beclin 1, autophagy related Mus musculus 115-123 34085745-4 2021 We found that Ace-BECN1 levels were increased in 3T3-L1 adipocyte differentiation and isoproterenol-/TNF-alpha-stimulated lipolysis and in subcutaneous and visceral adipose tissues of high-fat diet mice. Isoproterenol 86-99 beclin 1, autophagy related Mus musculus 18-23 34085745-5 2021 K414 was identified as an acetylation site of BECN1, which affects the stability of the BECN1 protein. k414 0-4 beclin 1, autophagy related Mus musculus 46-51 34085745-5 2021 K414 was identified as an acetylation site of BECN1, which affects the stability of the BECN1 protein. k414 0-4 beclin 1, autophagy related Mus musculus 88-93 34210978-6 2021 The autophagy inducer Tat-Beclin1 D11, not the mTOR inhibitor rapamycin, decreased the plasma levels of the glucogenic amino acid and restored the blood glucose levels in aged FR mice. Glucose 153-160 beclin 1, autophagy related Mus musculus 26-33 34162415-9 2021 Our findings indicated that DS promoted the mitophagy by increasing the LC3II and Beclin 1 and decreasing the levels of p62 protein in BV-2 cell. ds 28-30 beclin 1, autophagy related Mus musculus 82-90 34132336-7 2022 Treating SMMHC-ERT2-Cre+/-TBCEfl/fl mice with the ER stress modulator tauroursodeoxycholic acid amplified Raptor/Beclin-1-dependent autophagy and reversed vascular dysfunction. tbcefl 26-32 beclin 1, autophagy related Mus musculus 113-121 34132336-7 2022 Treating SMMHC-ERT2-Cre+/-TBCEfl/fl mice with the ER stress modulator tauroursodeoxycholic acid amplified Raptor/Beclin-1-dependent autophagy and reversed vascular dysfunction. Fluorides 33-35 beclin 1, autophagy related Mus musculus 113-121 34132336-7 2022 Treating SMMHC-ERT2-Cre+/-TBCEfl/fl mice with the ER stress modulator tauroursodeoxycholic acid amplified Raptor/Beclin-1-dependent autophagy and reversed vascular dysfunction. ursodoxicoltaurine 70-95 beclin 1, autophagy related Mus musculus 113-121 34421301-6 2021 Results: We found that HI induction significantly elevated mRNA levels of NOD1 (3.54 folds change) and autophagy-related genes including Atg5 (3.89 folds change) and Beclin-1 (3.34 folds change). hi 23-25 beclin 1, autophagy related Mus musculus 166-174 34281337-6 2021 GLA activated autophagy, autophagosome-lysosome fusion, and LKB1-AMPK-mTOR signaling and upregulated mRNA and protein expressions of Beclin-1, autophagy-related 5, and liver kinase B1 (LKB1). gamma-Linolenic Acid 0-3 beclin 1, autophagy related Mus musculus 133-141 34222477-9 2021 Interestingly, THC administration suppressed the expression of the autophagy markers LC3, Atg5, and Beclin 1. tetrahydrocurcumin 15-18 beclin 1, autophagy related Mus musculus 100-108 34348084-6 2021 Interestingly, PCT induced DNA damage, the resulting autophagosome, the accumulation of Beclin-1, the reduction of p62, the translocation and the formation of LC3-II. Polychloroterphenyl Compounds 15-18 beclin 1, autophagy related Mus musculus 88-96 35364735-17 2022 The potential mechanistic insight of Lira in alleviating Cup-induced neurotoxicity via: (1) AMPK/SIRT1 pathways activation resulting in the stimulation of brain autophagy flux (confirmed by lowering Beclin-1 and LC3-B protein expression). lira 37-41 beclin 1, autophagy related Mus musculus 199-207 34080667-6 2021 Furthermore, CXCR4 silencing with or without doxorubicin increased the expression of beclin 1 and light chain 3B, and the number of autophagosomes and autolysosomes, as well as induced autophagic flux activation by suppressing the PI3K/AKT/mTOR signaling pathway. Doxorubicin 45-56 beclin 1, autophagy related Mus musculus 85-93 35362638-5 2022 In addition, we found that echinacoside elevated FOXO1 expression in the hippocampus, increased the expression of autophagy-related proteins including Beclin 1, ATG5, ATG7 and LC3, and reduced P62 expression. echinacoside 27-39 beclin 1, autophagy related Mus musculus 151-159 35619282-13 2022 The expression level of LC3I, LC3II, bcl2 and beclin1 in liver increased significantly after treatment with UDCA under HS conditions. Ursodeoxycholic Acid 108-112 beclin 1, autophagy related Mus musculus 46-53 35606613-9 2022 The expressions of both SIRT1 and Beclin-1 as well as the ratio of LC3II/LC3I were significantly upregulated in the ALS mice, while melatonin reversed the upregulation of both SIRT1 and Beclin-1 expression and LC3II/LC3I ratio in a dose-dependent manner. Melatonin 132-141 beclin 1, autophagy related Mus musculus 34-42 35606613-9 2022 The expressions of both SIRT1 and Beclin-1 as well as the ratio of LC3II/LC3I were significantly upregulated in the ALS mice, while melatonin reversed the upregulation of both SIRT1 and Beclin-1 expression and LC3II/LC3I ratio in a dose-dependent manner. Melatonin 132-141 beclin 1, autophagy related Mus musculus 186-194 35606613-11 2022 Furthermore, SIRT1 silencing notably reduced the effect of melatonin on Beclin-1, LC3II/LC3I, and p62. Melatonin 59-68 beclin 1, autophagy related Mus musculus 72-80 35554836-8 2022 Treatment with BG significantly abrogated apoptosis and autophagy in lymphoid organs in diabetic mice by restoring the expression levels of LC3, Beclin-1, P62, Bcl-2, and Bax; decreasing inflammatory signals by downregulating the expression of MCP-1 and HSP-70; and promoting cell survival by enhancing the phosphorylation of AKT. O(6)-benzylguanine 15-17 beclin 1, autophagy related Mus musculus 145-153 35447319-8 2022 Furthermore, 3-MA causes lower Beclin-1, higher mTOR and p62 on both gene and protein levels, while the expression of t-tau, p-tau, GSK-3beta and CDK5 are upregulated, demonstrating that impaired autophagy disturbs the clearance of tau. 3-methyladenine 13-17 beclin 1, autophagy related Mus musculus 31-39 35543153-8 2022 The upregulation of LC3-II, a classical autophagy marker, and the downregulation of mTOR and its downstream molecule Beclin1 were observed in established D-allose-resistant LLC cells, which were more sensitive to cell death induced by HCQ. allose 154-162 beclin 1, autophagy related Mus musculus 117-124 35543153-8 2022 The upregulation of LC3-II, a classical autophagy marker, and the downregulation of mTOR and its downstream molecule Beclin1 were observed in established D-allose-resistant LLC cells, which were more sensitive to cell death induced by HCQ. Hydroxychloroquine 235-238 beclin 1, autophagy related Mus musculus 117-124 35266018-15 2022 The overexpression of Beclin-1 in neurons significantly attenuated I/R-induced damage and promoted DSB repair. 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 99-102 beclin 1, autophagy related Mus musculus 22-30 35290903-8 2022 Conversely, PCBP1 upregulation inhibited autophagy activation via direct binding to the CU-rich elements on the 3"-untranslated region (3"-UTR) of BECN1 mRNA. Copper 88-90 beclin 1, autophagy related Mus musculus 147-152 35176588-8 2022 In addition, the upregulation of autophagy-related marker genes Beclin-1 and LC3II/LC3I in chondrocytes indicated that autophagy could be activated upon shikonin treatment. shikonin 153-161 beclin 1, autophagy related Mus musculus 64-72 35227772-11 2022 However, sSTEAP4 inhibited AMPK phosphorylation and Beclin1/LC3 expression under H2O2-deficiency situation, but the results were conversed with H2O2 stimulation. Hydrogen Peroxide 81-85 beclin 1, autophagy related Mus musculus 52-59 35529035-7 2022 Results: Compared with that of the control group, body weight of mice in DSS group was significantly reduced, stool was not formed or presented with loose stools, there was occult blood or blood in the stool, hair color lost luster, disease activity index (DAI) score was significantly increased, and colonic mucosal epithelial cells showed colitis; LC3-II/LC3-I and Beclin1 expression were significantly decreased (P < 0.05), p62 was significantly increased, and autophagy was not obvious. dss 73-76 beclin 1, autophagy related Mus musculus 367-374 35529035-8 2022 In addition, compared with that of the DSS group, the diet of mice in the Cur group was improved, the decline of body weight was slowed down, the hair glossiness was restored, the blood in the stool gradually decreased or occulted, the DAI score was decreased, the colon tissue was significantly improved, the expressions of LC3-II/LC3-I and Beclin1 were significantly increased (P < 0.05), and the p62 was significantly decreased. dss 39-42 beclin 1, autophagy related Mus musculus 342-349 35443746-8 2022 Pharmacological inhibition of autophagy by 3-methyladenine (3-MA) did not affect the diminishing effect of RPV on viability, while treatment with wortmannin or depletion of specific autophagy proteins (ATG5, Beclin-1 and SQSTM1/p62) rescued the detrimental effect of high concentrations of RPV on the viability of activated HSC. Wortmannin 146-156 beclin 1, autophagy related Mus musculus 208-216 35248719-9 2022 Noteworthy, YTH domain was essential for YTHDF1 to prolong the half-life of BECN1 mRNA in DHA-induced HSC ferroptosis. artenimol 90-93 beclin 1, autophagy related Mus musculus 76-81 34997871-4 2022 RESULTS: The results showed that melatonin can significantly inhibit the occurrence of autophagy, accompanied by a significant decrease in the expression of Becn1, LC3, and FOXO1 (P < 0.05), a significant increase in the expression of p62 and pAKT (P < 0.05), and a significant decrease in ROS level (P < 0.05). Melatonin 33-42 beclin 1, autophagy related Mus musculus 157-162 35000049-9 2022 The observation of autophagosomes and the changes in expressions of LC3II/I, Beclin1, and Atg7 indicated that RSV could reverse the autophagy defect associated with HFD. Resveratrol 110-113 beclin 1, autophagy related Mus musculus 77-84 35065059-5 2022 Importantly, naringenin potently activated autophagy as evidenced by the increased Beclin-1 expression and LC3 II/LC3 I ratio. naringenin 13-23 beclin 1, autophagy related Mus musculus 83-91 35328525-11 2022 Furthermore, BECLIN-1 depletion inhibited testosterone production and StAR expression. Testosterone 42-54 beclin 1, autophagy related Mus musculus 13-21 35138214-6 2022 MAIN OUTCOMES AND RESULTS: Compared with the 50% alcohol group, the expression of p-mTOR/mTOR and p-4E-BP1/4E-BP1 in hippocampus was significantly decreased, while the expression of p-JNK/JNK, Beclin1, and LC3 was significantly increased in the medium- and high-dose puerarin groups. Alcohols 49-56 beclin 1, autophagy related Mus musculus 193-200 35261310-8 2022 Western blot results showed that the relative expression of protein p62 increased significantly and that the relative expression levels of the Beclin1 and the LC3 proteins significantly decreased with increasing BPA concentration. bisphenol A 212-215 beclin 1, autophagy related Mus musculus 143-150 35261310-9 2022 qRT-PCR results showed that the relative expression level of autophagy-related p62 mRNA increased significantly and that the relative expression level of Beclin1 mRNA decreased significantly with increasing BPA concentration. bisphenol A 207-210 beclin 1, autophagy related Mus musculus 154-161 35211405-5 2022 In the present study, we report that Utt-B promotes pro-survival autophagy in hepatic cancer cells as evidenced by the increased expression of autophagy-related proteins, including LC3-II, Beclin1, ATG 5, and ATG 7, as well as a rise in the autophagic flux. utt-b 37-42 beclin 1, autophagy related Mus musculus 189-196 35298966-5 2022 Moreover, autophagy was inhibited by BPA through decreasing p-AMPK/AMPK and increasing p-mTOR/mTOR, and further down-regulating autophagy proteins ATG6, LC3II/I ratio, and up-regulating autophagy flux protein p62. bisphenol A 37-40 beclin 1, autophagy related Mus musculus 147-151 35298966-8 2022 Intriguingly, ABT-737 might promote ATG6 expression. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 14-17 beclin 1, autophagy related Mus musculus 36-40 35298966-10 2022 Both Bcl-2 and ATG6 were involved in the regulation of apoptosis and autophagy by BPA. bisphenol A 82-85 beclin 1, autophagy related Mus musculus 15-19 35153674-10 2021 The accumulation of LC3-II, Beclin-1, and ATG7 are decreased, and the expression of Rab7 and Syntaxin 17 are increased significantly after RPM treatment. Sirolimus 139-142 beclin 1, autophagy related Mus musculus 28-36 35057792-11 2022 Beclin1, LC3B, LAMP2, TGF-ss, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis. Cytidine Diphosphate 68-71 beclin 1, autophagy related Mus musculus 0-7 34059044-6 2021 Furthermore, silibinin strongly induced apoptosis and autophagy by up-regulating the expression of Bax, Caspase-3, Atg5, Atg7 and BECN1 and down-regulating Bcl-2. Silybin 13-22 beclin 1, autophagy related Mus musculus 130-135 34990787-7 2022 In addition, BPS-treated TM3 cells showed an accumulation of autophagic vacuoles, together with increased Beclin1 and P62 expression and elevated LC3B-II/LC3B-I ratio. bis(4-hydroxyphenyl)sulfone 13-16 beclin 1, autophagy related Mus musculus 106-113 34038756-4 2021 The present study found that As3+ exposure induced a concomitant activation of apoptosis and autophagy in Neuro-2a cells, which was accompanied with the increase of phosphatidylserine exposure on outer membrane leaflets and apoptotic cell population, and the activation of caspase-3, -7, and PARP as well as the elevation of protein expressions of LC3-II, Atg-5, and Beclin-1, and the accumulation of autophagosome. as3+ 29-33 beclin 1, autophagy related Mus musculus 367-375 34051206-5 2021 Western blot analysis showed that anemoside B4 elevated the expression of Beclin-1, LC3II/LC3I, Atg3, Atg5, and Atg7, and reduced p62, suggesting the restoration of autophagy flux in liver. anemoside B4 34-46 beclin 1, autophagy related Mus musculus 74-82 34054847-7 2021 Surprisingly, treatment with Sildenafil inhibited nitrosative stress and augmented the levels of LC3, beclin-1, ATG5, p-CREB and BDNF and decreased mTOR levels, as well as augmented p-AMPK. Sildenafil Citrate 29-39 beclin 1, autophagy related Mus musculus 102-110 34054847-8 2021 In conclusion, we propose that Sildenafil alleviates EAE by activating autophagy via the eNOS-NO-AMPK-mTOR-LC3-beclin1-ATG5 and eNOS-NO-AMPK-mTOR-CREB-BDNF pathways in the spinal cord. Sildenafil Citrate 31-41 beclin 1, autophagy related Mus musculus 111-118 33956507-13 2021 Furthermore, cells exposed to PS-MPs had higher protein levels of LC3 and Beclin 1. Polystyrenes 30-32 beclin 1, autophagy related Mus musculus 74-82 34007179-8 2021 In the echinacoside group, while the expressions of Beclin 1 and LC3-II increased (P < 0.01), the expression levels of P62 and alpha-synuclein decreased significantly (P < 0.01). echinacoside 7-19 beclin 1, autophagy related Mus musculus 52-60 33887379-7 2021 Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 beclin 1, autophagy related Mus musculus 120-128 33887379-7 2021 Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy. 3-methyladenine 45-49 beclin 1, autophagy related Mus musculus 120-128 33887379-7 2021 Furthermore, the PI3K inhibitor (LY294002 or 3-MA) and/or PAP reversed the Cd-induced upregulated expression of LC3 II, Beclin-1, and PI3K class III, with a synergy between PI3K inhibitor and PAP against Cd-induced autophagy. Cadmium 75-77 beclin 1, autophagy related Mus musculus 120-128 33887379-8 2021 The findings suggested that PAP partially prevented Cd-induced autophagic cell death in neurons by inhibiting the PI3K class III/Beclin-1 signaling pathway in vitro and in vivo. Cadmium 52-54 beclin 1, autophagy related Mus musculus 129-137 33794800-11 2021 Additionally, ABT-263 blocked the binding of Bcl-2 to Beclin-1, thus induced Beclin-1-dependent autophagy. navitoclax 14-21 beclin 1, autophagy related Mus musculus 77-85 33880124-6 2021 After DEX pretreatments, paeoniflorin promoted osteoblast differentiation and mineralization characterized by increase in Runx2, ALP, beclin-1, and LC3-II/LC3-I ratio levels and a decrease in apoptosis. peoniflorin 25-37 beclin 1, autophagy related Mus musculus 134-142 33880124-9 2021 The results showed that paeoniflorin increased alkaline phosphatase (ALP) activity and upregulated the expression of osteocalcin and beclin-1 but reduced the levels of Bax and C-terminal telopeptide of type I collagen (CTX-1). peoniflorin 24-36 beclin 1, autophagy related Mus musculus 133-141 33921050-9 2021 NAC treatment upregulated ATG-5 (p < 0.0001), beclin-1 (p < 0.0001) and LC3-I to LC3-II (p < 0.0001) conversion, which was inhibited in the DA treatment group. Acetylcysteine 0-3 beclin 1, autophagy related Mus musculus 46-54 33280021-9 2021 GRK4 overexpression in cardiomyocytes aggravated apoptosis, repressed autophagy, and decreased beclin-1 expression, which were partially rescued by the autophagy agonist rapamycin. Sirolimus 170-179 beclin 1, autophagy related Mus musculus 95-103 33794800-12 2021 CONCLUSION: ABT-263 enhanced the macrophage function in aged mouse by increasing the Trem-2 receptors and inducing a beclin-1-dependent autophagy, consequently, protected the aged mouse from sepsis. navitoclax 12-19 beclin 1, autophagy related Mus musculus 117-125 32757698-11 2021 The expressions of LC3-II, Beclin-1, and HMGB1 and the ratio of LC3-II/LC3-I were increased in H/R-processed cardiomyocytes and further raised by TMZ pretreatment. Trimetazidine 146-149 beclin 1, autophagy related Mus musculus 27-35 32070194-9 2021 Moreover, the efflux of FAs and their reuptake or subsequent extracellular trafficking to adjacent cells may play an important role in cell-to-cell lipid exchange and signaling.Abbreviations: ACTB: beta actin; ADRA1A: adrenergic receptor alpha, 1a; ALB: albumin; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A1; BECN1: beclin 1; BHBA: beta-hydroxybutyrate; BSA: bovine serum albumin; CDH1: e-cadherin; CQ: chloroquine; CTSB: cathepsin B; DGAT: diacylglycerol O-acyltransferase; FA: fatty acid; HFD: high-fat diet; LAMP1: lysosomal-associated membrane protein 1; LD: lipid droplet; LIPA/LAL: lysosomal acid lipase A; LLME: Leu-Leu methyl ester hydrobromide; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: mucolipin 1; MEF: mouse embryo fibroblast; PBS: phosphate-buffered saline; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PLIN: perilipin; PNPLA2/ATGL patatin-like phospholipase domain containing 2; RUBCN (rubicon autophagy regulator); SM: sphingomyelin; TAG: triacylglycerol; TMEM192: transmembrane protein 192; VLDL: very low density lipoprotein. Fatty Acids 24-27 beclin 1, autophagy related Mus musculus 340-345 33539326-9 2021 Stimulating autophagic flux via Tat-beclin 1 peptide or torin 2, promotes autophagic degradation of mutant myocilin and reduces elevated IOP in Tg-MYOCY437H mice. Thioguanine 144-146 beclin 1, autophagy related Mus musculus 36-44 33794800-0 2021 ABT-263 enhanced bacterial phagocytosis of macrophages in aged mouse through Beclin-1-dependent autophagy. navitoclax 0-7 beclin 1, autophagy related Mus musculus 77-85 33794800-11 2021 Additionally, ABT-263 blocked the binding of Bcl-2 to Beclin-1, thus induced Beclin-1-dependent autophagy. navitoclax 14-21 beclin 1, autophagy related Mus musculus 54-62 32070194-9 2021 Moreover, the efflux of FAs and their reuptake or subsequent extracellular trafficking to adjacent cells may play an important role in cell-to-cell lipid exchange and signaling.Abbreviations: ACTB: beta actin; ADRA1A: adrenergic receptor alpha, 1a; ALB: albumin; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A1; BECN1: beclin 1; BHBA: beta-hydroxybutyrate; BSA: bovine serum albumin; CDH1: e-cadherin; CQ: chloroquine; CTSB: cathepsin B; DGAT: diacylglycerol O-acyltransferase; FA: fatty acid; HFD: high-fat diet; LAMP1: lysosomal-associated membrane protein 1; LD: lipid droplet; LIPA/LAL: lysosomal acid lipase A; LLME: Leu-Leu methyl ester hydrobromide; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: mucolipin 1; MEF: mouse embryo fibroblast; PBS: phosphate-buffered saline; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PLIN: perilipin; PNPLA2/ATGL patatin-like phospholipase domain containing 2; RUBCN (rubicon autophagy regulator); SM: sphingomyelin; TAG: triacylglycerol; TMEM192: transmembrane protein 192; VLDL: very low density lipoprotein. Fatty Acids 24-27 beclin 1, autophagy related Mus musculus 347-355 33603856-9 2021 In addition, immunohistochemical analysis of Beclin1 revealed an increased pericentral staining intensity following TM pretreatment. Tunicamycin 116-118 beclin 1, autophagy related Mus musculus 45-52 33609317-9 2021 RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group. Arginine 30-40 beclin 1, autophagy related Mus musculus 151-159 33624733-11 2021 After they were treated with different doses of NAR, the LC3B and beclin 1 levels were improved while the p62 protein level was decreased. naringenin 48-51 beclin 1, autophagy related Mus musculus 66-74 33609317-9 2021 RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group. dapagliflozin 9-22 beclin 1, autophagy related Mus musculus 151-159 33668422-6 2021 In complementary experiments, silencing of Fosl-2 with antisense GapmeR oligonucleotides suppressed production of type I collagen, myofibroblast marker alpha smooth muscle actin and autophagy marker Beclin-1 in cardiac fibroblasts. Oligonucleotides 72-88 beclin 1, autophagy related Mus musculus 199-207 33369168-0 2021 Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders. Urea 71-75 beclin 1, autophagy related Mus musculus 0-8 33369168-8 2021 In conclusion, Beclin-1-dependent activation of autophagy improved biochemical and clinical phenotypes of proximal and distal defects of the urea cycle. Urea 141-145 beclin 1, autophagy related Mus musculus 15-23 33359793-6 2021 Exposure to METH significantly downregulated tyrosine hydroxylase (TH) proteins, but upregulated MAOA, Beclin1, Atg5, and LC3-II. Methamphetamine 12-16 beclin 1, autophagy related Mus musculus 103-110 33197516-7 2021 Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis. tert-Butylhydroperoxide 13-17 beclin 1, autophagy related Mus musculus 111-119 33197516-7 2021 Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis. Trehalose 39-48 beclin 1, autophagy related Mus musculus 111-119 33239448-2 2021 We have now determined that in cultured podocytes, high glucose led to increases in activation of EGFR signaling but decreases in autophagy activity as indicated by decreased beclin-1 and inhibition of LC3B autophagosome formation as well as increased rubicon (an autophagy inhibitor) and SQSTM1 (autophagy substrate). Glucose 56-63 beclin 1, autophagy related Mus musculus 175-183 33542675-8 2021 ATG5, Beclin1, and LC3BII/I were significantly upregulated in asthma mice, which were greatly suppressed by the introduction of YFP, indicating that YFP ameliorated the autophagy in the lung of the mouse asthma model. yfp 149-152 beclin 1, autophagy related Mus musculus 6-13 33345685-5 2021 The nlrp3 or casp1 knockout CI-AKI mice and iohexol-treated HK-2 cells with MCC950 pretreatment exhibited upregulated levels of HIF1A, BECN1, BNIP3, and LC3B-II, as well as enhanced colocalization of LC3B with BNIP3 and mitochondria, and colocalization of mitochondria with lysosomes. Iohexol 44-51 beclin 1, autophagy related Mus musculus 135-140 33396170-5 2021 Also, over-exposure to Cu increased mRNA and protein expressions of Beclin1, Atg12, Atg5, Atg16L1, Atg7, Atg3, and LC3 and decreased mRNA and protein expressions of p62. Copper 23-25 beclin 1, autophagy related Mus musculus 68-75 33417139-7 2022 Furthermore, in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA"s cardioprotective effects are at least in part through downregulation of autophagic flux. empagliflozin 93-97 beclin 1, autophagy related Mus musculus 55-63 32767958-6 2021 OBJECTIVE: To investigate the effects of TQ on the major autophagy mediators, Beclin-1 and LC3 expression, as wells autophagic activity in TNBC cells. thymoquinone 41-43 beclin 1, autophagy related Mus musculus 78-86 32838711-0 2021 Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy. Melatonin 0-9 beclin 1, autophagy related Mus musculus 81-88 32838711-0 2021 Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy. Hydrogen Peroxide 47-51 beclin 1, autophagy related Mus musculus 81-88 32838711-12 2021 In addition, H2O2 decreased the levels of Beclin1 and Atg5/12/16, which were reversed by rapamycin or melatonin. Hydrogen Peroxide 13-17 beclin 1, autophagy related Mus musculus 42-49 32838711-12 2021 In addition, H2O2 decreased the levels of Beclin1 and Atg5/12/16, which were reversed by rapamycin or melatonin. Sirolimus 89-98 beclin 1, autophagy related Mus musculus 42-49 32838711-12 2021 In addition, H2O2 decreased the levels of Beclin1 and Atg5/12/16, which were reversed by rapamycin or melatonin. Melatonin 102-111 beclin 1, autophagy related Mus musculus 42-49 32838711-14 2021

Conclusion: In conclusion, these results demonstrate that melatonin protects HT22 hippocampal neurons from H2O2- induced injury by increasing the levels of the Beclin1 and Atg proteins to activate autophagy. Melatonin 62-71 beclin 1, autophagy related Mus musculus 164-171 32838711-14 2021

Conclusion: In conclusion, these results demonstrate that melatonin protects HT22 hippocampal neurons from H2O2- induced injury by increasing the levels of the Beclin1 and Atg proteins to activate autophagy. Hydrogen Peroxide 111-115 beclin 1, autophagy related Mus musculus 164-171 33290962-8 2021 In addition, NAD + increased the expressions of the autophagy-related proteins LC3-II/I and Beclin 1, and reduced the expression of p62. NAD 13-18 beclin 1, autophagy related Mus musculus 92-100 32557691-11 2021 In addition, high glucose and asprosin resulted in reduced expression of LC3-II/LC3-I, beclin 1, and increased expression of P62. Glucose 18-25 beclin 1, autophagy related Mus musculus 87-95 32557691-11 2021 In addition, high glucose and asprosin resulted in reduced expression of LC3-II/LC3-I, beclin 1, and increased expression of P62. asprosin 30-38 beclin 1, autophagy related Mus musculus 87-95 33157088-0 2021 Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway. paeonol 0-7 beclin 1, autophagy related Mus musculus 119-127 33157088-12 2021 Furthermore, paeonol could activate class III PI3K-Beclin-1 pathway significantly. paeonol 13-20 beclin 1, autophagy related Mus musculus 51-59 33157088-13 2021 Gene silencing of either class III PI3K or Beclin-1 could reverse the effects of paeonol on VSMCs autophagy and apoptosis. paeonol 81-88 beclin 1, autophagy related Mus musculus 43-51 33157088-14 2021 SIGNIFICANCE: Based on our results, paeonol could induce VSMCs autophagy by activating class III PI3K/Beclin-1 signaling pathway, thus ultimately inhibiting VSMCs apoptosis. paeonol 36-43 beclin 1, autophagy related Mus musculus 102-110 32519911-7 2021 The treatment with OA effectively suppressed the DMBA-initiated liver carcinogenesis via modulation of antioxidant status, induction of apoptosis and autophagy through modulating the expression of Caspase-3, Bcl-2 and Beclin-1, inhibiting angiogenesis (VEGF), proliferation (PCNA), and improved liver function and histological picture with a reduction in AFP level. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 49-53 beclin 1, autophagy related Mus musculus 218-226 33205940-6 2020 Notably, the coreleased Mn2+ serves as the cofactor of DNAzyme for effective self-activation, which suppresses the expression of Beclin 1 protein, the key initiator of autophagy, resulting in a significantly strengthened antitumor effect of RAP. Manganese(2+) 24-28 beclin 1, autophagy related Mus musculus 129-137 33381582-9 2020 Coenzyme Q10 significantly inhibited the elevation of sequestosome-1, interleukin-1beta, oligomerization domain-like receptor 3 and nucleotide-binding, interleukin-6, and tumor necrosis factor-alpha expression levels; coenzyme Q10 also increased beclin 1 levels. coenzyme Q10 0-12 beclin 1, autophagy related Mus musculus 246-254 33327462-10 2020 In addition, Tat-p27 significantly increased microtubule-associated protein 1A/1B light chain 3A/3B expression and ameliorated the H2O2 or ischemia-induced increases of p62 and decreases of beclin-1 in the HT22 cells and hippocampus. Hydrogen Peroxide 131-135 beclin 1, autophagy related Mus musculus 190-198 32721735-2 2020 We showed for the first time that the neurotoxic effects of DDE involve autophagy, as demonstrated by elevated levels of Becn1, Map1lc3a/MAP1LC3A, Map1lc3b, and Nup62/NUP62 and an increase in autophagosome formation. Dichlorodiphenyl Dichloroethylene 60-63 beclin 1, autophagy related Mus musculus 121-126 33318630-7 2020 In addition, spermidine enhanced beclin-1-dependent autophagy and autophagy modulators in IPF fibroblasts and BLM-induced mouse lungs, in which inflammation and collagen deposition were significantly decreased. Spermidine 13-23 beclin 1, autophagy related Mus musculus 33-41 33058849-9 2020 In vitro study noted that corticosterone challenge compromised cardiomyocyte function, provoked lipid peroxidation and mitochondrial injury, the effects of which were nullified by Beclin1 haploinsufficiency, inhibitors of lipoxygenase, ferroptosis and autophagy. Corticosterone 26-40 beclin 1, autophagy related Mus musculus 180-187 33058849-11 2020 CONCLUSION: These data suggest that Beclin1 haploinsufficiency protects against cold exposure-induced cardiac dysfunction possibly through corticosterone- and ferroptosis-mediated mechanisms. Corticosterone 139-153 beclin 1, autophagy related Mus musculus 36-43 32891637-7 2020 Our data revealed that Beclin1 deficiency exacerbated smoke exposure-induced myocardial anomalies in geometry, fractional shortening, cardiomyocyte function, intracellular Ca2+ handling, TEM ultrastructure, and inflammation along with pronounced apoptosis and O2- production. Oxygen 260-263 beclin 1, autophagy related Mus musculus 23-30 32989388-7 2020 Additionally, LiCl increased mTOR phosphorylation, reduced beclin1 expression and reduced the LC3 II/I expression ratio. Lithium Chloride 14-18 beclin 1, autophagy related Mus musculus 59-66 32683043-6 2020 RESULTS: All D-isomer TAT-Beclin-1-treated DMM mice had no difference in the degree of cartilage degeneration compared to PBS-injected DMM mice. dimethylmyleran 43-46 beclin 1, autophagy related Mus musculus 26-34 31930515-3 2020 Here, we determined the effect of DON on the Class III phosphatidylinositol 3-kinase (PIK3C3)/beclin 1/B cell lymphoma-2 (Bcl-2) pathway in PC12 cells and the relationship between autophagy and apoptosis. deoxynivalenol 34-37 beclin 1, autophagy related Mus musculus 94-120 33138323-0 2020 TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. Doxorubicin 120-131 beclin 1, autophagy related Mus musculus 16-24 33138323-4 2020 The SGLT2 inhibitor, empagliflozin, protects the heart from doxorubicin cardiomyopathy in mice, by acting through a novel Beclin 1-toll-like receptor (TLR) 9-sirtuin-(SIRT) 3 axis. empagliflozin 21-34 beclin 1, autophagy related Mus musculus 122-157 33138323-4 2020 The SGLT2 inhibitor, empagliflozin, protects the heart from doxorubicin cardiomyopathy in mice, by acting through a novel Beclin 1-toll-like receptor (TLR) 9-sirtuin-(SIRT) 3 axis. Doxorubicin 60-71 beclin 1, autophagy related Mus musculus 122-157 33050029-0 2020 Epigallocatechin-3-Gallate Reduces Visceral Adiposity Partly through the Regulation of Beclin1-Dependent Autophagy in White Adipose Tissues. epigallocatechin gallate 0-26 beclin 1, autophagy related Mus musculus 87-94 33050029-8 2020 Adipocyte-specific knockout of Beclin1 mitigated the effects of EGCG on visceral adipose tissue mass and glucose tolerance, indicating that the anti-obesity effect of EGCG requires Beclin1-dependent autophagy. epigallocatechin gallate 64-68 beclin 1, autophagy related Mus musculus 31-38 33050029-8 2020 Adipocyte-specific knockout of Beclin1 mitigated the effects of EGCG on visceral adipose tissue mass and glucose tolerance, indicating that the anti-obesity effect of EGCG requires Beclin1-dependent autophagy. Glucose 105-112 beclin 1, autophagy related Mus musculus 31-38 33050029-8 2020 Adipocyte-specific knockout of Beclin1 mitigated the effects of EGCG on visceral adipose tissue mass and glucose tolerance, indicating that the anti-obesity effect of EGCG requires Beclin1-dependent autophagy. epigallocatechin gallate 167-171 beclin 1, autophagy related Mus musculus 31-38 33050029-8 2020 Adipocyte-specific knockout of Beclin1 mitigated the effects of EGCG on visceral adipose tissue mass and glucose tolerance, indicating that the anti-obesity effect of EGCG requires Beclin1-dependent autophagy. epigallocatechin gallate 167-171 beclin 1, autophagy related Mus musculus 181-188 33050029-9 2020 Collectively, our data demonstrated that EGCG has anti-obesity effects through the upregulation of Beclin1-dependent autophagy and lipid catabolism in white adipose tissue (WAT). epigallocatechin gallate 41-45 beclin 1, autophagy related Mus musculus 99-106 32910484-6 2020 Melatonin inhibited neuronal pyroptosis and excessive autophagy, as evidenced by decreased levels of NLRP3, cleaved caspase-1, GSDMD-N, IL-1beta, LC3, Beclin1, and ATG12 both in vivo and in vitro. Melatonin 0-9 beclin 1, autophagy related Mus musculus 151-158 32468217-5 2020 The expression of Beclin-1, LC3B, p62, Bcl-2, Bax, BACE1, GFAP, MBP and ET-1 mRNA were determined by RT-PCR; the expression of Beclin-1 was detected by Western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (HE) staining; and the correlation of Beclin-1 with other VD-related proteins was analysed by Pearson"s correlation. haematoxylin-eosin 258-276 beclin 1, autophagy related Mus musculus 127-135 32468217-5 2020 The expression of Beclin-1, LC3B, p62, Bcl-2, Bax, BACE1, GFAP, MBP and ET-1 mRNA were determined by RT-PCR; the expression of Beclin-1 was detected by Western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (HE) staining; and the correlation of Beclin-1 with other VD-related proteins was analysed by Pearson"s correlation. haematoxylin-eosin 258-276 beclin 1, autophagy related Mus musculus 127-135 32468217-5 2020 The expression of Beclin-1, LC3B, p62, Bcl-2, Bax, BACE1, GFAP, MBP and ET-1 mRNA were determined by RT-PCR; the expression of Beclin-1 was detected by Western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (HE) staining; and the correlation of Beclin-1 with other VD-related proteins was analysed by Pearson"s correlation. Helium 278-280 beclin 1, autophagy related Mus musculus 127-135 32468217-5 2020 The expression of Beclin-1, LC3B, p62, Bcl-2, Bax, BACE1, GFAP, MBP and ET-1 mRNA were determined by RT-PCR; the expression of Beclin-1 was detected by Western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (HE) staining; and the correlation of Beclin-1 with other VD-related proteins was analysed by Pearson"s correlation. Helium 278-280 beclin 1, autophagy related Mus musculus 127-135 33571967-10 2020 Exposure to 5 mM NaF induced RANKL (receptor activator of nuclear factor kappaB ligand) and cathepsin K expression in periodontal tissues, while ATG5 and Beclin-1 expression was abrogated by 5 mM NaF. Sodium Fluoride 17-20 beclin 1, autophagy related Mus musculus 154-162 32952341-12 2020 Resveratrol also increased the levels of LC3B (by 1.39-fold compared with DSS group) and Beclin-1 (by 1.49-fold compared with DSS group) (P < 0.05), as well as the number of autophagosomes, which implies that the resveratrol may alleviate intestinal mucosal barrier dysfunction in DSS-induced UC mice by enhancing autophagy. Resveratrol 0-11 beclin 1, autophagy related Mus musculus 89-97 32963573-8 2020 Furthermore, the protein expressions of beclin1, LC3B, and P62 were also significantly increased in high glucose-induced podocytes. Glucose 105-112 beclin 1, autophagy related Mus musculus 40-47 32882870-12 2020 FKB+doxorubicin-mediated dysregulated Bax/Bcl-2, Beclin-1/Bcl-2 ratios suggested apoptosis, autophagy induction in AGS cells. flavokawain B 0-3 beclin 1, autophagy related Mus musculus 49-57 32882870-12 2020 FKB+doxorubicin-mediated dysregulated Bax/Bcl-2, Beclin-1/Bcl-2 ratios suggested apoptosis, autophagy induction in AGS cells. Doxorubicin 4-15 beclin 1, autophagy related Mus musculus 49-57 32340512-0 2020 miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1. mir-25-3p 0-9 beclin 1, autophagy related Mus musculus 117-125 33350241-13 2020 However, as compared with the model group, the number of activities, ChAT, TH, and p62 expression levels in the rapamycin group were significantly reduced(P<0.05), and the APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly increased(P<0.05). Sirolimus 112-121 beclin 1, autophagy related Mus musculus 212-220 33350241-14 2020 As compared with the 3 MA group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in the low and medium dose piperine groups and rapamycin group(P<0.05); howe-ver, their first foot licking time was significantly prolonged, APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were increased significantly(P<0.05). Sirolimus 169-178 beclin 1, autophagy related Mus musculus 303-311 33350241-15 2020 As compared with the medopar group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in low dose piperine group and rapamycin group(P<0.05), but their first foot licking time was significantly extended, and APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly increased(P<0.05). Sirolimus 156-165 beclin 1, autophagy related Mus musculus 287-295 33070168-7 2020 Amitriptyline interfered with the fusion of autophagosome and lysosome through the activation of PI3K/Akt/mTOR pathway and Beclin 1 acetylation, and regulated lysosome positioning by increasing the interaction between proteins Arl8, SKIP, and kinesin. Amitriptyline 0-13 beclin 1, autophagy related Mus musculus 123-131 32896555-0 2020 Aspirin restores endothelial function by mitigating 17beta-estradiol-induced alpha-SMA accumulation and autophagy inhibition via Vps15 scaffold regulation of Beclin-1 phosphorylation. Aspirin 0-7 beclin 1, autophagy related Mus musculus 158-166 32896555-0 2020 Aspirin restores endothelial function by mitigating 17beta-estradiol-induced alpha-SMA accumulation and autophagy inhibition via Vps15 scaffold regulation of Beclin-1 phosphorylation. Estradiol 52-68 beclin 1, autophagy related Mus musculus 158-166 32896555-7 2020 Aspirin promoted Beclin1 phosphorylation in autophagy initiation complexes and enhanced autophagy. Aspirin 0-7 beclin 1, autophagy related Mus musculus 17-24 33049148-5 2021 Moreover, C3G improved the autophagy decrease that was induced by high glucose through regulating the expression level of LC3 II/LC3 I, Beclin1 and p62. Glucose 71-78 beclin 1, autophagy related Mus musculus 136-143 32384961-7 2020 RT-qPCR and immunoblotting were used to detect the effects of metformin on the expression of TXNIP and autophagy associated genes-BECN1 and LC3B in the sciatic nerves of pain model mice. Metformin 62-71 beclin 1, autophagy related Mus musculus 130-135 32384961-11 2020 The results showed that the expression of TXNIP and autophagy related indexes-BECN1 and LC3B in sciatic nerve decreased significantly after oxaliplatin treatment. Oxaliplatin 140-151 beclin 1, autophagy related Mus musculus 78-83 33571967-10 2020 Exposure to 5 mM NaF induced RANKL (receptor activator of nuclear factor kappaB ligand) and cathepsin K expression in periodontal tissues, while ATG5 and Beclin-1 expression was abrogated by 5 mM NaF. Sodium Fluoride 196-199 beclin 1, autophagy related Mus musculus 154-162 32598088-3 2020 We have shown that inhibition of Beclin 1, a key activator in the initiation phase of autophagy, attenuates imiquimod (IMQ)-induced epidermal hyperplasia in adult mice as well as naturally occurring hyperproliferation in neonatal mouse epidermis. Imiquimod 108-117 beclin 1, autophagy related Mus musculus 33-41 32598088-3 2020 We have shown that inhibition of Beclin 1, a key activator in the initiation phase of autophagy, attenuates imiquimod (IMQ)-induced epidermal hyperplasia in adult mice as well as naturally occurring hyperproliferation in neonatal mouse epidermis. Imiquimod 119-122 beclin 1, autophagy related Mus musculus 33-41 32744026-10 2020 Treatment with BSJZF significantly reduced the area of the aortic plaque, decreased expression of TNF-a, IFN-r, and p62, and increased expression of IL-10, LC3, and Beclin 1. bsjzf 15-20 beclin 1, autophagy related Mus musculus 165-173 32542594-6 2020 Naringenin can induce autophagy promoting proteins such as ULK1, Beclin1, ATG5, and ATG7 in Neuro2a cells and primary mouse neurons as well. naringenin 0-10 beclin 1, autophagy related Mus musculus 65-72 32714408-6 2020 Furthermore, CDDP was also found stimulating ob/ob mice hepatic autophagy by increasing the expression of Beclin1 and LC3B, while decreasing P62 expression. cddp 13-17 beclin 1, autophagy related Mus musculus 106-113 32344065-9 2020 Adipocyte-specific KO of Beclin1 led to hypertrophic enlargement of lipid droplets in BAT and impaired CL316243-induced lipolysis/lipid mobilization and energy expenditure. disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate 103-111 beclin 1, autophagy related Mus musculus 25-32 32760216-17 2020 Conclusion: HOTAIR negatively targets miR-17-5p to activate Beclin1-mediated cell autophagy, thereby enhancing sunitinib resistance in RC cells. Sunitinib 111-120 beclin 1, autophagy related Mus musculus 60-67 32708051-5 2020 The expressions of autophagy-related factors such as beclin-1, p62, LC3-I, and LC3-II were increased in the soleus muscle of SAMP1 mice; however, beta-cryptoxanthin administration inhibited this increase. Beta-Cryptoxanthin 146-164 beclin 1, autophagy related Mus musculus 53-61 32765037-11 2020 The results indicated an elevated level of autophagy in rapamycin and puerarin groups compared with the DN model, as demonstrated by the upregulated expression of autophagy markers Beclin-1, LC3II, and Atg5, and downregulated p62 expression. Sirolimus 56-65 beclin 1, autophagy related Mus musculus 181-189 32733943-5 2020 The outcomes represented that Polyphyllin I promoted A375 cell apoptosis via upregulating Bax level and cleaved caspase-3 level and downregulating Bcl-2 level, inhibited the growth of A375 cells at the G0/G1 phase, and enhanced cell autophagy via regulating the levels of Beclin 1, LC3II, and p62. polyphyllin I 30-43 beclin 1, autophagy related Mus musculus 272-280 32714192-7 2020 Dex-Ace induced myocilin, alpha-actin, Beclin-1, and LC3-II/LC-I ratio, and lowered p62, while synchronous RAP treatment further activated autophagy and neutralized the induction of myocilin and alpha-actin. dexamethasone acetate 0-7 beclin 1, autophagy related Mus musculus 39-47 32361652-9 2020 The results demonstrated geniposide decreased cell death and the levels of NLRP3, ASC, cleaved- caspase-1 and IL-1beta, whereas significantly increased the conversion of LC3 and Beclin-1 expression, decreased the expression of P62. geniposide 25-35 beclin 1, autophagy related Mus musculus 178-186 32344356-4 2020 RESULTS: Our findings confirmed that cafestol preconditioning groups could reduce the levels of ALT and AST, alleviate liver pathological damage, suppress the release of inflammation mediators, inhibit the production of pro-apoptosis protein including caspase-3, caspase-9 and Bax, decrease the expression of autophagy-linked protein including Beclin-1 and LC3, increase anti-apoptosis protein Bcl-2, and restrain the activation of ERK and PPARgamma. cafestol 37-45 beclin 1, autophagy related Mus musculus 344-352 32044640-0 2020 Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells. Arsenic 0-7 beclin 1, autophagy related Mus musculus 80-87 32044640-3 2020 Hence, this study aimed to explore the roles of mTOR and Beclin1-Vps34/PI3K complex during As-induced-toxicity using Rapamycin (mTOR inhibitor), Beclin1 siRNA and 3-methyladenine (3-MA, Vps34/PI3K inhibitor) in testicular stromal cells. Arsenic 91-93 beclin 1, autophagy related Mus musculus 57-64 32044640-6 2020 Meanwhile, arsenic treatment up-regulated autophagic markers including LC3, Atg7, Beclin1 and Vps34 expressions, mTOR downstream autophagy related genes and the Beclin1-Vps34/PI3K complex associated members. Arsenic 11-18 beclin 1, autophagy related Mus musculus 82-89 32044640-6 2020 Meanwhile, arsenic treatment up-regulated autophagic markers including LC3, Atg7, Beclin1 and Vps34 expressions, mTOR downstream autophagy related genes and the Beclin1-Vps34/PI3K complex associated members. Arsenic 11-18 beclin 1, autophagy related Mus musculus 161-168 32044640-7 2020 Furthermore, silencing of Beclin1, and inhibition of Vps34/PI3K and mTOR altered the arsenic-induced autophagosomes formation. Arsenic 85-92 beclin 1, autophagy related Mus musculus 26-33 32044640-8 2020 However, p62, the substrate protein of autophagy, was also up-regulated by arsenic administration independent on Beclin1-Vps34/PI3K complex. Arsenic 75-82 beclin 1, autophagy related Mus musculus 113-120 32044640-9 2020 Altogether, our results revealed that arsenic exposure induced autophagosomes formation via regulation of the Beclin1-Vps34/PI3K complex and mTOR pathway; the blockage of autophagosomes degradation maybe due to impaired function of lysosomes. Arsenic 38-45 beclin 1, autophagy related Mus musculus 110-117 31373534-9 2020 DeSUMOylation of BECN1 restrained autophagy induction under basal conditions and especially upon starvation when SENP3 had accumulated in response to the increased generation of reactive oxygen species. Reactive Oxygen Species 178-201 beclin 1, autophagy related Mus musculus 17-22 32352125-4 2020 Monodansylcadaverine (MDC) staining results indicate the occurrence of autophagy induced by TBBQ, which was manifested by activation of LC3-II concurrent with the increased levels of Beclin1 and reduced levels of p62. monodansylcadaverine 22-25 beclin 1, autophagy related Mus musculus 183-190 32456371-21 2020 On ID 14 and 21, the mRNA expressions of p62, LC3 II, and Beclin-1 in the skin tissue of mice in bleomycin group were significantly higher than those in blank control group (t=0.74, 0.70, 0.58, 0.49, 0.51, 0.74, P<0.05) and simple PBS group (t=0.94, 0.65, 0.65, 0.77, 0.49, 0.51, P<0.05). Bleomycin 97-106 beclin 1, autophagy related Mus musculus 58-66 32456371-22 2020 On ID 28, the mRNA expressions of p62 and Beclin-1 in the skin tissue of mice in bleomycin group were significantly lower than those in blank control group (t=0.50, 0.44, P<0.05) and simple PBS group (t=0.97, 0.55, P<0.05), and that of LC3 II was significantly higher than that in blank control group and simple PBS group, respectively (t=0.51, 0.98, P <0.01). Bleomycin 81-90 beclin 1, autophagy related Mus musculus 42-50 32456371-22 2020 On ID 28, the mRNA expressions of p62 and Beclin-1 in the skin tissue of mice in bleomycin group were significantly lower than those in blank control group (t=0.50, 0.44, P<0.05) and simple PBS group (t=0.97, 0.55, P<0.05), and that of LC3 II was significantly higher than that in blank control group and simple PBS group, respectively (t=0.51, 0.98, P <0.01). pbs 190-193 beclin 1, autophagy related Mus musculus 42-50 32456371-24 2020 On ID 14, the protein expressions of p62 and Beclin-1 in the skin tissue of mice in bleomycin group were significantly higher than those in blank control group (t=0.86, 0.89, P<0.05) and simple PBS group (t=0.42, 0.89, P<0.05). Bleomycin 84-93 beclin 1, autophagy related Mus musculus 45-53 32456371-24 2020 On ID 14, the protein expressions of p62 and Beclin-1 in the skin tissue of mice in bleomycin group were significantly higher than those in blank control group (t=0.86, 0.89, P<0.05) and simple PBS group (t=0.42, 0.89, P<0.05). pbs 194-197 beclin 1, autophagy related Mus musculus 45-53 32456371-25 2020 On ID 21, the protein expressions of p62, LC3 II, and Beclin-1 in the skin tissue of mice in bleomycin group were significantly higher than those in blank control group and simple PBS group (t=0.82, 0.45, 0.50, 0.79, 0.51, 0.50, P<0.01). Bleomycin 93-102 beclin 1, autophagy related Mus musculus 54-62 32456371-26 2020 On ID 28, the protein expressions of p62, LC3 II, and Beclin-1 in the skin tissue of mice in bleomycin group were significantly lower than those in blank control group and simple PBS group (t=0.77, 0.54, 0.52, 0.50, 0.51, 0.50, P<0.05). Bleomycin 93-102 beclin 1, autophagy related Mus musculus 54-62 31928234-7 2020 Furthermore, FIHMI treatment decreased mRNA expression of Beclin-1 and LC3B protein expression in METH-induced 661W cells suggesting autophagy is reduced. methyl-1-formyl-6-oxa-6H-indene-4-carboxylate 13-18 beclin 1, autophagy related Mus musculus 58-66 31928234-7 2020 Furthermore, FIHMI treatment decreased mRNA expression of Beclin-1 and LC3B protein expression in METH-induced 661W cells suggesting autophagy is reduced. Methamphetamine 98-102 beclin 1, autophagy related Mus musculus 58-66 32239627-8 2020 Mechanistic study showed that miR-153-3p disrupted the interaction between Bcl-2 and Beclin1 by targeting Bcl-2, thereby facilitating autophagy in chondrocytes under sevoflurane preconditioning. Sevoflurane 166-177 beclin 1, autophagy related Mus musculus 85-92 32239627-10 2020 Collectively, miR-153-3p overexpression blocks the interaction between Bcl-2 and Beclin1 via down-regulation of Bcl-2 to promote autophagy of chondrocytes, thus protecting knee joint against IRI after TKA under sevoflurane preconditioning. Sevoflurane 211-222 beclin 1, autophagy related Mus musculus 81-88 32186763-0 2020 beta-asarone modulates Beclin-1, LC3 and p62 expression to attenuate Abeta40 and Abeta42 levels in APP/PS1 transgenic mice with Alzheimer"s disease. asarone 0-12 beclin 1, autophagy related Mus musculus 23-31 32186763-9 2020 It was demonstrated that beta-asarone treatment reduced the number of senile plaques and autophagosomes, and decreased Abeta40, Abeta42, APP and Beclin-1 expression in the hippocampus of model mice compared with untreated model mice. asarone 25-37 beclin 1, autophagy related Mus musculus 145-153 32340263-9 2020 Empagliflozin and linagliptin, both as monotherapy and in combination, enhanced the areas of glomerular staining for beclin-1 and LAMP-1 and increased Vv of autophagosomes and autolysosomes in podocytes. empagliflozin 0-13 beclin 1, autophagy related Mus musculus 117-125 32340263-9 2020 Empagliflozin and linagliptin, both as monotherapy and in combination, enhanced the areas of glomerular staining for beclin-1 and LAMP-1 and increased Vv of autophagosomes and autolysosomes in podocytes. Linagliptin 18-29 beclin 1, autophagy related Mus musculus 117-125 32362825-4 2020 Furthermore, bicyclol efficiently induced the conversion of LC3 and enhanced the liver expressions of ATG7 and Beclin-1. bicyclol 13-21 beclin 1, autophagy related Mus musculus 111-119 32362899-0 2020 Salmonella Enteritidis Effector AvrA Suppresses Autophagy by Reducing Beclin-1 Protein. avra 32-36 beclin 1, autophagy related Mus musculus 70-78 32362899-8 2020 AvrA-reduction of Beclin-1 protein expression is through the JNK pathway. avra 0-4 beclin 1, autophagy related Mus musculus 18-26 32362899-12 2020 In organoids and infected mice, we explored the physiologically related effects and mechanism of AvrA in reducing Beclin-1 through the JNK pathway, thus attenuating autophagic responses. avra 97-101 beclin 1, autophagy related Mus musculus 114-122 32274533-8 2020 Further, the enhanced autophagy under Dex treatment was verified in primary cultured osteoclasts, as shown by the increased levels of Beclin 1 and LC3-II/LC3-I and the autophagy complex formation members including Atg1, Atg13, and Atg7. Dexamethasone 38-41 beclin 1, autophagy related Mus musculus 134-142 32439945-6 2020 The autophagy-related molecules (Nrf2, p62 and Beclin 1) were activated in RAW264.7 cells and bone marrow-derived macrophages under CCL-34 treatment. CCL 34 132-138 beclin 1, autophagy related Mus musculus 47-55 32187724-0 2020 ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress. Reactive Oxygen Species 54-57 beclin 1, autophagy related Mus musculus 9-17 32187724-4 2020 We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion. Reactive Oxygen Species 150-153 beclin 1, autophagy related Mus musculus 48-56 32187724-4 2020 We report that CHK2 binds to and phosphorylates Beclin 1 at Ser90/Ser93, thereby impairing Beclin 1-Bcl-2 autophagy-regulatory complex formation in a ROS-dependent fashion. Reactive Oxygen Species 150-153 beclin 1, autophagy related Mus musculus 91-99 32187724-7 2020 Taken together, these results indicate that the ROS-ATM-CHK2-Beclin 1-autophagy axis serves as a physiological adaptation pathway that protects cells exposed to pathological conditions from stress-induced tissue damage. Reactive Oxygen Species 48-51 beclin 1, autophagy related Mus musculus 61-69 32394642-5 2022 Overexpression of miR-142-5p in a cardiomyocyte model of H/R enhanced apoptosis and increased the expression of interleukin-1beta (IL-1beta), cleaved-caspase 3 and p62, but inhibited autophagy and decreased expression of Beclin-1, protein 1 light chain 3B (LC3B) and B cell leukemia/lymphoma 2 (Bcl-2) at the mRNA and protein level. mir-142-5p 18-28 beclin 1, autophagy related Mus musculus 221-229 32394642-7 2022 We identified Beclin-1 as a target gene for miR-142-5p. mir-142-5p 44-54 beclin 1, autophagy related Mus musculus 14-22 32239565-9 2020 The results demonstrated that LINC00337 upregulated TPX2, consequently leading to elevated levels of Beclin1 and LC3II/LC3I, promoted cell viability and autophagy, while inhibiting apoptosis and chemosensitivity to DDP in ESCC. linc00337 30-39 beclin 1, autophagy related Mus musculus 101-108 32352125-4 2020 Monodansylcadaverine (MDC) staining results indicate the occurrence of autophagy induced by TBBQ, which was manifested by activation of LC3-II concurrent with the increased levels of Beclin1 and reduced levels of p62. tbbq 92-96 beclin 1, autophagy related Mus musculus 183-190 32326642-5 2020 Here, we established two autophagy models through serum starvation and rapamycin treatment and detected that the overexpression of Mark4 increased the expression of autophagy-related factors Beclin1, ATG7, and significantly decreased the autophagy substrate P62. Sirolimus 71-80 beclin 1, autophagy related Mus musculus 191-198 32268299-6 2020 Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). Spermidine 0-10 beclin 1, autophagy related Mus musculus 81-89 32268299-6 2020 Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). Spermine 15-23 beclin 1, autophagy related Mus musculus 81-89 32248306-9 2020 CARD9 interacted with RUN domain Beclin-1-interacting cysteine-rich-containing (Rubicon), a negative regulator of autophagy, and enhanced UV-irradiation-resistance-associated gene (UVRAG)-Beclin1-phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) interaction and UVRAG-Vps16-mediated Rab7 activation to promote autophagosome formation, maturation, and endocytosis. Cysteine 54-62 beclin 1, autophagy related Mus musculus 33-41 32248306-9 2020 CARD9 interacted with RUN domain Beclin-1-interacting cysteine-rich-containing (Rubicon), a negative regulator of autophagy, and enhanced UV-irradiation-resistance-associated gene (UVRAG)-Beclin1-phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3) interaction and UVRAG-Vps16-mediated Rab7 activation to promote autophagosome formation, maturation, and endocytosis. Cysteine 54-62 beclin 1, autophagy related Mus musculus 188-195 31747048-7 2020 Moreover, morphine treatment significantly increased BECLIN-1 expression and decreased the p-mTOR/mTOR and SQSTM1/p62 levels, whereas knockdown of RACK1 prevented morphine-induced autophagy in vitro. Morphine 10-18 beclin 1, autophagy related Mus musculus 53-61 32058932-14 2020 Hydrogen treatment decreased the ratio of p-mTOR/mTOR and the expression of p62 and increased the ratio of p-AMPK/AMPK, LC3II/LC3I and the expression of TREM-2 and Beclin-1 in LPS-treated BV-2 cells. Hydrogen 0-8 beclin 1, autophagy related Mus musculus 164-172 32045770-6 2020 SB203580 and PDTC reduced total cells and neutrophils in BALF in LPS-induced mice, accompanying with decreased levels of TNF-alpha, IL-6, MPO, LPO and MDA and the expressions of beclin-1, Atg5 and LC3II, but with the up-regulated activities of SOD and GSH-Px, as well as p62 protein expression. SB 203580 0-8 beclin 1, autophagy related Mus musculus 178-186 32045770-6 2020 SB203580 and PDTC reduced total cells and neutrophils in BALF in LPS-induced mice, accompanying with decreased levels of TNF-alpha, IL-6, MPO, LPO and MDA and the expressions of beclin-1, Atg5 and LC3II, but with the up-regulated activities of SOD and GSH-Px, as well as p62 protein expression. prolinedithiocarbamate 13-17 beclin 1, autophagy related Mus musculus 178-186 31846746-8 2020 UroA significantly upregulated the protein levels of microtubule-associated protein 1 light chain 3-II (LC3II) and beclin1, downregulated sequestosome 1 (p62) accompanied by decreased expression of apoptotic protein cleaved caspase3 in pancreas of diabetic mice. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 0-4 beclin 1, autophagy related Mus musculus 115-122 32352125-4 2020 Monodansylcadaverine (MDC) staining results indicate the occurrence of autophagy induced by TBBQ, which was manifested by activation of LC3-II concurrent with the increased levels of Beclin1 and reduced levels of p62. monodansylcadaverine 0-20 beclin 1, autophagy related Mus musculus 183-190 32057287-10 2020 Low dosage of TM abated LC3I expression, increased LC3II and Beclin1 expression, triggered ER stress and AM autophagy, and alleviated pathological changes of AMs in ALI mice. Tunicamycin 14-16 beclin 1, autophagy related Mus musculus 61-68 32184643-0 2020 Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2. Curcumin 0-8 beclin 1, autophagy related Mus musculus 113-120 32184643-12 2020 The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2. Curcumin 107-115 beclin 1, autophagy related Mus musculus 41-48 32184643-15 2020 Discussion: Together, the results showed that curcumin inhibited podocyte apoptosis and accelerated cell autophagy via regulating Beclin1/UVRAG/Bcl2. Curcumin 46-54 beclin 1, autophagy related Mus musculus 130-137 30990365-5 2020 Additionally, in the presence of cocaine, microglia also exhibited upregulated expression of autophagosome markers, BECN1, MAP1LC3B-II, and SQSTM1. Cocaine 33-40 beclin 1, autophagy related Mus musculus 116-121 32306669-11 2020 Compared with the SiO(2) stimulation group, the LC3IIand Beclin 1 protein levels of RAW264.7 cells were gradually down-regulated by increasing the dose of 4-PBA. sio(2) 18-24 beclin 1, autophagy related Mus musculus 57-65 32306669-11 2020 Compared with the SiO(2) stimulation group, the LC3IIand Beclin 1 protein levels of RAW264.7 cells were gradually down-regulated by increasing the dose of 4-PBA. 4-phenylbutylamine 155-160 beclin 1, autophagy related Mus musculus 57-65 31894502-6 2020 Treatment with TIZ increased the Beclin-1 expression level and inhibited PI3K, Akt, mTOR, and ULK1 activation. tizoxanide 15-18 beclin 1, autophagy related Mus musculus 33-41 31893334-7 2020 In addition, inhibition of autophagy by 3-methyladenine and Beclin-1 siRNA impeded activation of HSCs cultured in 1% O2. Superoxides 117-119 beclin 1, autophagy related Mus musculus 60-68 31926917-10 2020 Additionally, nicotine enhanced the expression of LC3II/LC3I and beclin-1 but decreased the p62 protein level. Nicotine 14-22 beclin 1, autophagy related Mus musculus 65-73 31425668-14 2020 Autophagy was also increased by Dex-Ace treatment, indicating by the upregulation of LC3-I, LC3-II and beclin-1, and downregulation of p62. dexamethasone acetate 32-39 beclin 1, autophagy related Mus musculus 103-111 31675140-3 2020 Furthermore, DEHP significantly increased the levels of autophagy proteins LC3-II, Beclin1 and Atg5, as well as the ratio ofLC3-II/LC3-I. Diethylhexyl Phthalate 13-17 beclin 1, autophagy related Mus musculus 83-90 32010248-7 2020 Treatment with 1 microM puerarin for 72 h led to a significant upregulation in the expression level of microtubule-associated light chain 3 (LC3)B and Beclin1 proteins. puerarin 24-32 beclin 1, autophagy related Mus musculus 151-158 32051584-5 2020 TLR9 binds beclin 1, and this interaction is increased by energy stress (glucose starvation and endurance exercise) and decreased by a BCL2 mutation3,5 that blocks the disruption of BCL2-beclin 1 binding. Glucose 73-80 beclin 1, autophagy related Mus musculus 11-19 31732923-10 2020 Silymarin rescued from MPTP-induced increase in beclin-1, sequestosome, p-AMPK, and p-Ulk1 and decrease in LAMP-2, p-mTOR, and LAMP-2A levels. Silymarin 0-9 beclin 1, autophagy related Mus musculus 48-56 31732923-10 2020 Silymarin rescued from MPTP-induced increase in beclin-1, sequestosome, p-AMPK, and p-Ulk1 and decrease in LAMP-2, p-mTOR, and LAMP-2A levels. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 23-27 beclin 1, autophagy related Mus musculus 48-56 32051584-6 2020 TLR9 regulates the assembly of the endolysosomal phosphatidylinositol 3-kinase complex (PI3KC3-C2)-which contains beclin 1 and UVRAG-in skeletal muscle during exercise, and knockout of beclin 1 or UVRAG inhibits the cellular AMPK activation induced by glucose starvation. Phosphatidylinositols 49-69 beclin 1, autophagy related Mus musculus 114-122 31433241-13 2019 Inhibitor of ERK pathway SCH772984 further promoted the influence of MEG3 silence on morphine-caused Beclin-1 (1.97 times) and LC3-II/LC3-I (1.92 times) expressions decreases. SCH772984 25-34 beclin 1, autophagy related Mus musculus 101-109 31706213-7 2020 Furthermore, Becn1 and Atg7 siRNAs potentiated the caspase-3-dependent effect of triclocarban, which points to triclocarban-induced impairment of autophagy. triclocarban 81-93 beclin 1, autophagy related Mus musculus 13-18 31706213-7 2020 Furthermore, Becn1 and Atg7 siRNAs potentiated the caspase-3-dependent effect of triclocarban, which points to triclocarban-induced impairment of autophagy. triclocarban 111-123 beclin 1, autophagy related Mus musculus 13-18 31706213-8 2020 Indeed, triclocarban dysregulated the expression of autophagy-related genes, and caused a time-dependent inhibition of the mRNA expression of Becn1, Map1lc3a, Map1lc3b, Nup62, and Atg7, which was correlated with a decrease in the protein levels of MAP1LC3B, BECN1 and autophagosomes, but not NUP62 protein level which was increased. triclocarban 8-20 beclin 1, autophagy related Mus musculus 142-147 31706213-8 2020 Indeed, triclocarban dysregulated the expression of autophagy-related genes, and caused a time-dependent inhibition of the mRNA expression of Becn1, Map1lc3a, Map1lc3b, Nup62, and Atg7, which was correlated with a decrease in the protein levels of MAP1LC3B, BECN1 and autophagosomes, but not NUP62 protein level which was increased. triclocarban 8-20 beclin 1, autophagy related Mus musculus 258-263 31998441-10 2020 Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. Serotonin 14-23 beclin 1, autophagy related Mus musculus 141-149 31466007-0 2020 Arsenic-induced immunomodulatory effects disorient the survival-death interface by stabilizing the Hsp90/Beclin1 interaction. Arsenic 0-7 beclin 1, autophagy related Mus musculus 105-112 31466007-5 2020 In addition, pioneering evidences established the ability of arsenic to induce an up regulation of Hsp90, eventually resulting in stabilization of its client protein Beclin-1, an important autophagy-initiating factor. Arsenic 61-68 beclin 1, autophagy related Mus musculus 166-174 32741912-9 2020 Dioscin also enhanced the levels of Beclin-1 and LC3-II while decreased the level of p62. dioscin 0-7 beclin 1, autophagy related Mus musculus 36-44 32538851-9 2020 Furthermore, DNLA and metformin enhanced autophagy activity by increasing LC3-II, Beclin1, and Klotho, and by decreasing p62 in the hippocampus and cortex. dnla 13-17 beclin 1, autophagy related Mus musculus 82-89 32538851-9 2020 Furthermore, DNLA and metformin enhanced autophagy activity by increasing LC3-II, Beclin1, and Klotho, and by decreasing p62 in the hippocampus and cortex. Metformin 22-31 beclin 1, autophagy related Mus musculus 82-89 31906147-8 2019 In neurons, celastrol enhances autophagy, autophagosome biogenesis (Beclin 1 , Ambra1 , Vps34 , Atg7 , Atg12 , and LC3-II ), and mitophagy (PINK1 , DJ-1 , and LRRK2 ), and these might be associated with MPAK signaling pathways. celastrol 12-21 beclin 1, autophagy related Mus musculus 68-76 31934268-8 2019 We found increased expression of autophagy-related genes beclin-1 and JNK1 following Ubisol-Q10 treatment of AD fibroblasts. ubisol-q10 85-95 beclin 1, autophagy related Mus musculus 57-65 31934268-12 2019 Additionally, Ubisol-Q10 supplementation in the drinking water of double transgenic AD mice leads to increased expression of beclin-1 and JNK1 in the cortical region. ubisol-q10 14-24 beclin 1, autophagy related Mus musculus 125-133 31934268-12 2019 Additionally, Ubisol-Q10 supplementation in the drinking water of double transgenic AD mice leads to increased expression of beclin-1 and JNK1 in the cortical region. Water 57-62 beclin 1, autophagy related Mus musculus 125-133 31849474-0 2019 Heterozygous Disruption of Beclin 1 Alleviates Zinc Oxide Nanoparticles-Induced Disturbance of Cholesterol Biosynthesis in Mouse Liver. Zinc Oxide 47-57 beclin 1, autophagy related Mus musculus 27-35 31849474-0 2019 Heterozygous Disruption of Beclin 1 Alleviates Zinc Oxide Nanoparticles-Induced Disturbance of Cholesterol Biosynthesis in Mouse Liver. Cholesterol 95-106 beclin 1, autophagy related Mus musculus 27-35 31849474-6 2019 To further reveal the underlying toxic mechanisms, we detected the biomarkers of autophagy and found that pulmonary ZnONPs exposure led to the elevation of LC3B-II and Beclin 1, suggesting ZnONPs might trigger autophagy in liver tissues. znonps 116-122 beclin 1, autophagy related Mus musculus 168-176 31849474-6 2019 To further reveal the underlying toxic mechanisms, we detected the biomarkers of autophagy and found that pulmonary ZnONPs exposure led to the elevation of LC3B-II and Beclin 1, suggesting ZnONPs might trigger autophagy in liver tissues. znonps 189-195 beclin 1, autophagy related Mus musculus 168-176 31849474-8 2019 Conclusion: Pulmonary exposure of ZnONPs would induce the cholesterol biosynthesis disturbance in mouse liver through Beclin-1-dependent autophagy activation, suggesting that inhibition of autophagy may contribute to preventing the cholesterol biosynthesis disturbance and its associated pathologies induced by ZnONPs in liver. znonps 34-40 beclin 1, autophagy related Mus musculus 118-126 31849474-8 2019 Conclusion: Pulmonary exposure of ZnONPs would induce the cholesterol biosynthesis disturbance in mouse liver through Beclin-1-dependent autophagy activation, suggesting that inhibition of autophagy may contribute to preventing the cholesterol biosynthesis disturbance and its associated pathologies induced by ZnONPs in liver. Cholesterol 58-69 beclin 1, autophagy related Mus musculus 118-126 31849474-8 2019 Conclusion: Pulmonary exposure of ZnONPs would induce the cholesterol biosynthesis disturbance in mouse liver through Beclin-1-dependent autophagy activation, suggesting that inhibition of autophagy may contribute to preventing the cholesterol biosynthesis disturbance and its associated pathologies induced by ZnONPs in liver. Cholesterol 232-243 beclin 1, autophagy related Mus musculus 118-126 31849474-8 2019 Conclusion: Pulmonary exposure of ZnONPs would induce the cholesterol biosynthesis disturbance in mouse liver through Beclin-1-dependent autophagy activation, suggesting that inhibition of autophagy may contribute to preventing the cholesterol biosynthesis disturbance and its associated pathologies induced by ZnONPs in liver. znonps 311-317 beclin 1, autophagy related Mus musculus 118-126 30982359-15 2019 3-MA or si-Beclin-1 weakens the effects of GEN on LPS-treated MPC5 cells. geniposide 43-46 beclin 1, autophagy related Mus musculus 11-19 31610502-9 2019 Meanwhile, AFB1 caused testis abnormal autophagy with the characterization of increased expressions of LC3, Beclin-1, Atg5 and p62. Aflatoxin B1 11-15 beclin 1, autophagy related Mus musculus 108-116 31634464-12 2019 Moreover, the expression of LC3-II and beclin1 proteins were greatly reduced and the expression of p62 protein was ascended after intervention with 3-MA in ACY1215 group. ricolinostat 156-163 beclin 1, autophagy related Mus musculus 39-46 31566301-6 2020 Moreover, TOCP administration induced placental apoptosis and autophagy by upregulating P53, Bax, Beclin-1, ratio of LC3 II/LC3 I and Atg5 and downregulating Bcl-2 protein. tri-o-cresyl phosphate 10-14 beclin 1, autophagy related Mus musculus 98-106 31760035-7 2020 In addition, NAS treatment decreased the expression of Beclin-1 and LC3, along with ratio of Beclin-1/Bcl-2, but increased p62 expression following TBI. N-acetylserotonin 13-16 beclin 1, autophagy related Mus musculus 55-63 31760035-7 2020 In addition, NAS treatment decreased the expression of Beclin-1 and LC3, along with ratio of Beclin-1/Bcl-2, but increased p62 expression following TBI. N-acetylserotonin 13-16 beclin 1, autophagy related Mus musculus 93-101 31554002-8 2020 In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-alpha, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. astragaloside A 32-45 beclin 1, autophagy related Mus musculus 184-192 31554002-9 2020 3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect. 3-methyladenine 0-15 beclin 1, autophagy related Mus musculus 76-84 31816893-10 2019 Furthermore, the expression of LC3-II/I and Beclin1 were increased, which was consistent with the ability of quercetin to promote autophagy. Quercetin 109-118 beclin 1, autophagy related Mus musculus 44-51 31090940-6 2019 Alcohol-related decrease in mechanistic target of rapamycin (mTOR) and Ras homolog enriched in brain (Rheb), that initiate autophagy, correlated with increased Beclin1 and autophagy-related protein 7 (Atg7), proteins involved in phagophore-autophagosome formation, in ALD. Alcohols 0-7 beclin 1, autophagy related Mus musculus 160-167 31433241-13 2019 Inhibitor of ERK pathway SCH772984 further promoted the influence of MEG3 silence on morphine-caused Beclin-1 (1.97 times) and LC3-II/LC3-I (1.92 times) expressions decreases. Morphine 85-93 beclin 1, autophagy related Mus musculus 101-109 31775806-6 2019 Most importantly, we demonstrated that deletion of NRBF2, a component of the BECN1-PIK3C3 complex, which also associates with ULK1/2-FIP200 complex, impairs memory in mice, alters long-term potentiation (LTP), reduces autophagy in mouse hippocampus, and promotes Abeta accumulation. UNII-042A8N37WH 263-268 beclin 1, autophagy related Mus musculus 77-82 31552591-5 2019 Furthermore, Sch A activated expression of the autophagy-related proteins LC3-II, beclin1, parkin, and PINK1 and increased mTOR expression. schizandrin A 13-18 beclin 1, autophagy related Mus musculus 82-89 31930081-8 2019 Results: In present study, our results demonstrated that isoquercitrin (20 mg/kg/day) treatment achieved significantly higher SFI and higher amplitude of CMAP, promoted the nerve regeneration and remyelination, increased the production of GAP43, NF200, MAG and PMP22, alleviated target muscle atrophy and autophagy, and suppressed the expression of ATG7, PINK1 and Beclin1 in soleus muscles after sciatic nerve crush. isoquercitrin 57-70 beclin 1, autophagy related Mus musculus 365-372 31376498-10 2019 We determined that the mTOR/BECN1 (S14) pathway is involved in ethanol-induced autophagy in vivo. Ethanol 63-70 beclin 1, autophagy related Mus musculus 28-33 31302461-10 2019 More importantly, enhanced autophagy of macrophages by UA through increasing the expression of both LC3B and Beclin-1 led to alter macrophage function. ursolic acid 55-57 beclin 1, autophagy related Mus musculus 109-117 31680966-11 2019 MP treatment decreased the levels of LC3-II, p62/SQSTM1, and Beclin-1 and upregulated the levels of phosphorylated (p)-Akt and p-mTOR. Methylprednisolone 0-2 beclin 1, autophagy related Mus musculus 61-69 31591291-12 2019 Moreover, SFN treatment attenuated obesity-induced autophagy, as detected by LC3 and Beclin1. sulforaphane 10-13 beclin 1, autophagy related Mus musculus 85-92 31238056-7 2019 Moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tBCCAO-treated mice, and ESC treatment regulated the expression of mitophagy-related factors, including Bnip3, Beclin1, Pink1, and parkin, the LC-3 II/I ratio, and apoptosis-related factors, including p53, Bax, and caspase 3. tbccao 136-142 beclin 1, autophagy related Mus musculus 247-254 31238056-7 2019 Moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tBCCAO-treated mice, and ESC treatment regulated the expression of mitophagy-related factors, including Bnip3, Beclin1, Pink1, and parkin, the LC-3 II/I ratio, and apoptosis-related factors, including p53, Bax, and caspase 3. esculetin 161-164 beclin 1, autophagy related Mus musculus 247-254 31634464-11 2019 ACY1215 could induce autophagy in ALF mice and cell model group accompanied with an increase in expression of LC3-II and beclin-1 proteins and down-regulation of p62 protein. ricolinostat 0-7 beclin 1, autophagy related Mus musculus 121-129 31488728-5 2019 Curcumin treatment significantly increased the expression of Beclin1, Atg5, and Atg16L1, induced the formation of autophagosomes, and promoted autophagosome-lysosome fusion in N2a/APP695swe cells. Curcumin 0-8 beclin 1, autophagy related Mus musculus 61-68 31290228-9 2019 Administration of gefitinib (EGFR TKI) to mice with ocular and cerebral toxoplasmosis resulted in disease control that was dependent on Beclin 1. Gefitinib 18-27 beclin 1, autophagy related Mus musculus 136-144 31356776-8 2019 Furthermore, LPS, resorcinolnaphthalein and MLN-4760 significantly affected the expression of autophagy proteins Beclin-1, LC3-I and LC3-II. resorcinolnaphthalein 18-39 beclin 1, autophagy related Mus musculus 113-121 31356776-11 2019 Finally, we found that AMPK inhibitor (8-bAMP) and mTOR activator (propranolol) both abolished the effects of ACE2 activator (resorcinolnaphthalein) on the expression of lung autophagy proteins Beclin-1, LC3-I and LC3-II. 8-bamp 39-45 beclin 1, autophagy related Mus musculus 194-202 31356776-11 2019 Finally, we found that AMPK inhibitor (8-bAMP) and mTOR activator (propranolol) both abolished the effects of ACE2 activator (resorcinolnaphthalein) on the expression of lung autophagy proteins Beclin-1, LC3-I and LC3-II. Propranolol 67-78 beclin 1, autophagy related Mus musculus 194-202 31356776-11 2019 Finally, we found that AMPK inhibitor (8-bAMP) and mTOR activator (propranolol) both abolished the effects of ACE2 activator (resorcinolnaphthalein) on the expression of lung autophagy proteins Beclin-1, LC3-I and LC3-II. resorcinolnaphthalein 126-147 beclin 1, autophagy related Mus musculus 194-202 31616291-9 2019 Furthermore, salidroside reduced the expression of atrophic genes, including MuRF1 and MAFbx, autophagy genes, including PINK1, BNIP3, LC3B, ATG7, and Beclin1, and transcription factor forkhead box O3 A (Foxo3A), and improved the expression of myosin heavy chain and transcriptional factor phosphorylated Foxo3A. rhodioloside 13-24 beclin 1, autophagy related Mus musculus 151-158 31467666-9 2019 In addition, metformin significantly suppressed the activation of the PI3K/AKT/mToR pathway and decreased the mRNA and protein levels of LC3B and Beclin1, which were induced by Ang-II. Metformin 13-22 beclin 1, autophagy related Mus musculus 146-153 31410159-9 2019 TQ significantly inhibited the elevation of p62, IL-1beta, IL-6, MCP-1 and TNF-alpha levels as well as increased the LC3, beclin 1 and IL-10 levels in LT. PI3K expression in the TQ + CLP group was significantly decreased compared with that in the CLP group. thymoquinone 0-2 beclin 1, autophagy related Mus musculus 122-130 31410159-10 2019 TQ treatment effectively modulated the expression levels of p62, LC3, beclin 1, PI3K and proinflammatory cytokines, and may be an important agent for the treatment of sepsis-induced liver injury. thymoquinone 0-2 beclin 1, autophagy related Mus musculus 70-78 30878677-8 2019 Blocking autophagy by silencing Beclin1 or Atg7 abrogated the effect of cis-khellactone on macrophages. (+)-cis-Khellactone 72-87 beclin 1, autophagy related Mus musculus 32-39 31440142-7 2019 Western blotting results indicated that H2S pretreatment reversed the increase in caspase 3 cleavage and the decrease in Bcl-2, suppressed the activation of autophagy marker (LC3II and Beclin-1), and maintained the p62 level in injured striatum post-ICH. Hydrogen Sulfide 40-43 beclin 1, autophagy related Mus musculus 185-193 31440210-8 2019 Melatonin significantly reduced the fluorescence intensity of mitophagy via the Beclin-1/Bcl-2 pathway, which involves Beclin-1 and Bcl-2 proteins. Melatonin 0-9 beclin 1, autophagy related Mus musculus 80-88 31440210-8 2019 Melatonin significantly reduced the fluorescence intensity of mitophagy via the Beclin-1/Bcl-2 pathway, which involves Beclin-1 and Bcl-2 proteins. Melatonin 0-9 beclin 1, autophagy related Mus musculus 119-127 30793306-9 2019 Tauroursodeoxycholic acid not only obviously abolished VEGF-A-induced increase of IRE-1, GRP78/Bip, beclin-1 expression, and LC3-II/LC3-I, but also negated VEGF-A-induced tube formation and migration of HUVECs. ursodoxicoltaurine 0-25 beclin 1, autophagy related Mus musculus 100-108 31363726-13 2019 The results showed that the administration of CMP was able to overcome the STZ-treated autophagy deficiency, significantly increase the rate of autophagy in the kidney, promote the expression of Atg5, beclin1 and LC3 protein, and reduce the expression of p62 protein. Streptozocin 75-78 beclin 1, autophagy related Mus musculus 201-208 30720220-9 2019 The addition of GW4869 led to increased apoptotic capacity of myocardial cells, decreased microvascular formation ability of endothelial cells, enhanced autophagy ability, and elevated Beclin-1 level as well as ratio of LC3II/LC3I. GW 4869 16-22 beclin 1, autophagy related Mus musculus 185-193 30793306-10 2019 Furthermore, N-acetyl- l-cysteine markedly abrogated VEGF-A-increased ROS production, IRE-1, GRP78/Bip, beclin-1 expression, and LC3-II/LC3-I in the HUVECs. Acetylcysteine 13-33 beclin 1, autophagy related Mus musculus 104-112 31023527-4 2019 The exposure of hepatic cells to Oleate acid resulted in a significant reduction of LC3 accumulation together with enhancement of p62 protein expression and the mRNA levels of ATG7 and BECN1 were reduced as well. oleate acid 33-44 beclin 1, autophagy related Mus musculus 185-190 31051152-9 2019 TSA also restored the expression of markers of macro-autophagy (LC3-II and Beclin-1) and reduced phosphorylated mTOR, phosphorylated IRS, FOXO1 and FOXO3 activation. trichostatin A 0-3 beclin 1, autophagy related Mus musculus 75-83 30910592-6 2019 Further, we found that knockdown of Beclin-1 inhibited the stem cell-like properties and restored osimertinib cytotoxicity. osimertinib 98-109 beclin 1, autophagy related Mus musculus 36-44 31261758-0 2019 Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1. Doxorubicin 73-84 beclin 1, autophagy related Mus musculus 122-129 31261758-9 2019 The mTOR agonist MHY1485 was shown to abrogate the effect of TSA via the UNC-51-like kinase 1 (ULK1)-Beclin1/TFEB-LAMP1 signaling pathway in vitro, demonstrating that TSA protects against DIC by promoting autophagy via the Beclin1/LAMP1 signaling pathway. 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 17-24 beclin 1, autophagy related Mus musculus 101-108 31261758-9 2019 The mTOR agonist MHY1485 was shown to abrogate the effect of TSA via the UNC-51-like kinase 1 (ULK1)-Beclin1/TFEB-LAMP1 signaling pathway in vitro, demonstrating that TSA protects against DIC by promoting autophagy via the Beclin1/LAMP1 signaling pathway. 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 17-24 beclin 1, autophagy related Mus musculus 223-230 31261758-9 2019 The mTOR agonist MHY1485 was shown to abrogate the effect of TSA via the UNC-51-like kinase 1 (ULK1)-Beclin1/TFEB-LAMP1 signaling pathway in vitro, demonstrating that TSA protects against DIC by promoting autophagy via the Beclin1/LAMP1 signaling pathway. tanshinone 61-64 beclin 1, autophagy related Mus musculus 101-108 31261758-9 2019 The mTOR agonist MHY1485 was shown to abrogate the effect of TSA via the UNC-51-like kinase 1 (ULK1)-Beclin1/TFEB-LAMP1 signaling pathway in vitro, demonstrating that TSA protects against DIC by promoting autophagy via the Beclin1/LAMP1 signaling pathway. tanshinone 61-64 beclin 1, autophagy related Mus musculus 223-230 31212930-7 2019 As a result, we demonstrated that VC induced fibrosis-associated protein expression, such as connective tissue growth factor (CTGF), plasminogen activator inhibitor-1 (PAI-1) and collagen 1, and autophagy-associated protein expression, such as Beclin 1 and LC3-II, in kidney cells. Vinyl Chloride 34-36 beclin 1, autophagy related Mus musculus 244-252 31105816-6 2019 GA induced autophagy which was showed by enhanced number of autophagosomes through upregulating the protein levels of LC3-II/I and Beclin-1 and downregulating SQSTM1/P62. Glycyrrhizic Acid 0-2 beclin 1, autophagy related Mus musculus 131-139 31257808-11 2019 The protein expressions of Beclin-1 and LC-3, and the conversion of LC3-II from LC3-I were both up-regulated markedly in the mouse calvaria of TCP group (P<0.05). tricalcium phosphate 143-146 beclin 1, autophagy related Mus musculus 27-35 30807795-4 2019 In this study, we found that the 60-kDa BECN1 was specifically degraded to a 40-kDa fragment in hippocampal HT22 cells treated with 5 mM glutamate. Glutamic Acid 137-146 beclin 1, autophagy related Mus musculus 40-45 30689995-7 2019 In addition, betaine increased the expression of autophagy activators beclin 1, autophagy-related (Atg)4 and Atg5, as well as the presence of autophagic vesicles and degradation of autophagic target sequestosome 1/p62 in the liver of NAFLD mice. Betaine 13-20 beclin 1, autophagy related Mus musculus 70-104 30520138-5 2019 In a mouse model of CIH, we detected significant upregulation of miR-30a, a miRNA that targets 3"-untranslated region of autophagy-associated protein 6 (Beclin-1) messenger RNA (mRNA) for suppressing the protein translation, which subsequently attenuated the endothelial cell autophagy against cell death. cih 20-23 beclin 1, autophagy related Mus musculus 153-161 30645707-11 2019 Compared with ALI group, Baf and CQ obviously elevated the level of LC3II and Beclin 1, and reduced the LAMP2 and Rab7 expressions in CLP + Baf group and ALI + CQ group. triazinate 25-28 beclin 1, autophagy related Mus musculus 78-86 30645707-11 2019 Compared with ALI group, Baf and CQ obviously elevated the level of LC3II and Beclin 1, and reduced the LAMP2 and Rab7 expressions in CLP + Baf group and ALI + CQ group. Chloroquine 33-35 beclin 1, autophagy related Mus musculus 78-86 30845644-9 2019 Offspring that resulted from a resveratrol fed mother showed increase AMPKalpha activation, mTOR inhibition, and an increase in Pgc-1alpha gene expression and Beclin-1 protein levels. Resveratrol 31-42 beclin 1, autophagy related Mus musculus 159-167 30343389-10 2019 TQ inhibited plasma cTnT levels; improved ATP; significantly inhibited p62, NLRP3, caspase-1, IL-1beta, IL-18, IL-6, TNF-alpha, and MCP-1expressions; and increased beclin 1 and IL-10 level. thymoquinone 0-2 beclin 1, autophagy related Mus musculus 164-172 30816479-8 2019 Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group. Curcumin 13-21 beclin 1, autophagy related Mus musculus 105-165 30816479-8 2019 Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group. Resveratrol 25-36 beclin 1, autophagy related Mus musculus 105-165 30874543-5 2019 Here we demonstrate that the proteostasis regulator/transglutaminase 2 (TGM2) inhibitor cysteamine restores reduced Beclin 1 (BECN1) protein levels in mice bearing cysteamine-rescuable F508del-CFTR mutant, either in homozygosis or in compound heterozygosis with a null allele, but not in knock-out CFTR mice. Cysteamine 88-98 beclin 1, autophagy related Mus musculus 116-124 30874543-5 2019 Here we demonstrate that the proteostasis regulator/transglutaminase 2 (TGM2) inhibitor cysteamine restores reduced Beclin 1 (BECN1) protein levels in mice bearing cysteamine-rescuable F508del-CFTR mutant, either in homozygosis or in compound heterozygosis with a null allele, but not in knock-out CFTR mice. Cysteamine 88-98 beclin 1, autophagy related Mus musculus 126-131 30874543-6 2019 When cysteamine restored BECN1 expression, autophagy was increased and gliadin-induced inflammation was reduced. Cysteamine 5-15 beclin 1, autophagy related Mus musculus 25-30 30874543-7 2019 The beneficial effects of cysteamine on F508del-CFTR mice were lost when these mice were backcrossed into a Becn1 haploinsufficient/autophagy-deficient background. Cysteamine 26-36 beclin 1, autophagy related Mus musculus 108-113 30597782-7 2019 Then, to further explore the autophagy mechanism, microRNA (miR)-30a-5p, an expression inhibitor of Beclin1, was predicted through bioinformatics predictions and RT-PCR, and it was reduced in PCP-treated mice. Pentachlorophenol 192-195 beclin 1, autophagy related Mus musculus 100-107 30597782-9 2019 These results firstly indicate that, PCP exposure could downregulate the expression of miR-30a-5p, and then induced autophagy through upregulation of Beclin1 to result in fetal loss. Pentachlorophenol 37-40 beclin 1, autophagy related Mus musculus 150-157 30320895-7 2019 Moreover, elimination of TDP-43 inhibited H2 O2 -triggered autophagy, which appeared as decreased expression of LC3II/I and Beclin-1, along with p62 degradation. Hydrogen Peroxide 42-47 beclin 1, autophagy related Mus musculus 124-132 30520138-8 2019 Together, these data suggest that endothelial cell autophagy in CIH may be attenuated by miR-30a-mediated translational control of Beclin-1 as an important cause of endothelial cell dysfunction and damage. cih 64-67 beclin 1, autophagy related Mus musculus 131-139 30219962-10 2019 Compared with the normoxia group, mice in the CIH group had greater autophagy-related proteins (beclin-1 and LC3) expression. cih 46-49 beclin 1, autophagy related Mus musculus 96-104 30918581-8 2019 Results: The results showed that HNK treatment obviously recovered the postoperative decline and enhanced the expressions of LC3-II, Beclin-1, Parkin, and PINK1 at protein levels after surgery/sevoflurane treatment, which are both an autophagy marker and a mitophagy marker. Sevoflurane 193-204 beclin 1, autophagy related Mus musculus 133-141 30684442-7 2019 Evidence for enhanced autophagy, denoted by increased expression of LC3-II and Beclin1, was also seen after treatment with geniposide. geniposide 123-133 beclin 1, autophagy related Mus musculus 79-86 30635359-4 2019 Niclosamide inhibition of Wnt signaling is attenuated in autophagosome-deficient ATG5-/- MEF cells or cells expressing shRNA targeting Beclin1, a critical constituent of autophagosome. Niclosamide 0-11 beclin 1, autophagy related Mus musculus 135-142 29915883-4 2019 Sertoli cells were exposed to 0, 0.125, 0.25, and 0.5 mM NaF for 24 h. The results showed that fluoride exposure up-regulated Beclin1 and p62 mRNA and protein expression levels with concomitant down-regulated mRNA and protein expression levels of LC3 and Atg5. Sodium Fluoride 57-60 beclin 1, autophagy related Mus musculus 126-133 29915883-4 2019 Sertoli cells were exposed to 0, 0.125, 0.25, and 0.5 mM NaF for 24 h. The results showed that fluoride exposure up-regulated Beclin1 and p62 mRNA and protein expression levels with concomitant down-regulated mRNA and protein expression levels of LC3 and Atg5. Fluorides 95-103 beclin 1, autophagy related Mus musculus 126-133 29725949-8 2019 Moreover, FIR treatment supported the survival of Purkinje cells in the cerebellum and promoted the autophagy, as reflected by the induction of autophagic markers, LC3II and Beclin-1, concomitant with the reduction of p62 and ataxin-3 accumulation in cerebellar Purkinje cells, which might partially contribute to the rescue mechanism. fir 10-13 beclin 1, autophagy related Mus musculus 174-182 30675309-4 2019 Beclin 1 transfectants were subcutaneously injected into nude mice to determine tumor growth, and proliferation and apoptosis levels using Ki-67 immunostaining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), respectively. deoxyuridine triphosphate 211-215 beclin 1, autophagy related Mus musculus 0-8 30412732-5 2019 High glucose (D-glucose, 25 mM) increased mtROS production, resulting in increase of Beclin1 expression and the LC3-II/LC3-I ratio, leading to decreased cell viability. Glucose 5-12 beclin 1, autophagy related Mus musculus 85-92 30686973-7 2018 More importantly, Baicalin enhanced autophagy by detecting the autophagy markers (LC3, Beclin 1, and p62) using western blot and LC3 immunofluorescence staining, ameliorating mitochondrial apoptotic pathway evidenced by restoration of the TBI-induced translocation of Bax and cytochrome C. However, simultaneous treatment with 3-MA inhibited Baicalin-induced autophagy and abolished its protective effects on mitochondrial apoptotic pathway. baicalin 18-26 beclin 1, autophagy related Mus musculus 87-95 30551460-11 2019 Surprisingly, artesunate also evidently triggered ferritinophagy accompanied by up-regulation of LC3 (microtubule-associated protein light chain 3), Atg3, Atg5, Atg6/beclin1, Atg12 (autophagy related genes) and down-regulation of p62, FTH1 (ferritin heavy chain), NCOA4 (nuclear receptor co-activator 4) in activated HSCs. Artesunate 14-24 beclin 1, autophagy related Mus musculus 161-165 30551460-11 2019 Surprisingly, artesunate also evidently triggered ferritinophagy accompanied by up-regulation of LC3 (microtubule-associated protein light chain 3), Atg3, Atg5, Atg6/beclin1, Atg12 (autophagy related genes) and down-regulation of p62, FTH1 (ferritin heavy chain), NCOA4 (nuclear receptor co-activator 4) in activated HSCs. Artesunate 14-24 beclin 1, autophagy related Mus musculus 166-173 30412732-5 2019 High glucose (D-glucose, 25 mM) increased mtROS production, resulting in increase of Beclin1 expression and the LC3-II/LC3-I ratio, leading to decreased cell viability. Glucose 14-23 beclin 1, autophagy related Mus musculus 85-92 29792337-5 2019 TiO2 NPs-induced messenger RNA expression of autophagy-related proteins LC3 and Beclin-1 was also significantly increased compared with those of the unexposed control cells. titanium dioxide 0-4 beclin 1, autophagy related Mus musculus 80-88 30651797-11 2019 After 3-MA treatment the expression levels of Beclin1 and LC3-II/I were decreased, compared with CLP group, but accumulation of p62 occurred, and the degree of renal injury was increased. 3-methyladenine 6-10 beclin 1, autophagy related Mus musculus 46-53 30431070-7 2019 Accordingly, results from hematoxylin and eosin staining, western blotting and immunofluorescence staining demonstrated that beta-glucan accelerated the progress of atherosclerosis in apolipoprotein E-deficient mice and modulated expression of dectin-1, beclin-1 and light chain 3II/I in aortas similarly to that observed in macrophages. beta-Glucans 125-136 beclin 1, autophagy related Mus musculus 254-262 29792337-6 2019 LC3 and Beclin-1 protein expression levels were markedly increased with the increase of TiO2 NPs concentrations. titanium dioxide 88-92 beclin 1, autophagy related Mus musculus 8-16 30964118-6 2019 Beclin1 and ULK1 expressions and the LC3-II/LC3-I ratio in tumor tissues were altered by rapamycin, whereas mTOR, Notch1, CD133, and CD90 expressions were significantly inhibited by rapamycin in immunofluorescence assays. Sirolimus 182-191 beclin 1, autophagy related Mus musculus 0-7 30964118-8 2019 Conclusion: Tumor growth delay induced by rapamycin may be associated with the suppression of the cancer stem cell phenotype (Notch1, CD133, and CD90) and promotion of autophagy (mTOR, Beclin1, ULK1, and LC3-II/LC3-I ratio) in the murine S180 sarcoma model. Sirolimus 42-51 beclin 1, autophagy related Mus musculus 185-192 30448177-8 2018 RESULTS: The expression of Beclin 1 and the conversion of LC3I to LC3II were significantly increased after LPS treatment and reversed by H2S both in vivo and in vitro. Hydrogen Sulfide 137-140 beclin 1, autophagy related Mus musculus 27-35 30662655-19 2018 After administration of LY294002, the expression levels of Beclin-1, LC3 II/LC3-I, and GPX4 significantly decreased, but Cyt C significantly increased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 beclin 1, autophagy related Mus musculus 59-67 29752681-0 2018 Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. Morphine 40-48 beclin 1, autophagy related Mus musculus 17-24 30272354-5 2018 In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation. Capsaicin 14-23 beclin 1, autophagy related Mus musculus 261-269 30272354-5 2018 In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation. Sorafenib 28-37 beclin 1, autophagy related Mus musculus 261-269 30153466-0 2018 Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation. Diethylstilbestrol 0-18 beclin 1, autophagy related Mus musculus 71-79 30153466-0 2018 Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation. Diethylstilbestrol 20-23 beclin 1, autophagy related Mus musculus 71-79 30153466-6 2018 We observed that DES-induced thymic atrophy was associated with increased autophagy in thymocytes and significant upregulation in the expression of both Becn1 and LC3. Diethylstilbestrol 17-20 beclin 1, autophagy related Mus musculus 153-158 30153466-9 2018 Together, these data demonstrate for the first time that DES induces autophagy in thymocytes potentially through epigenetic changes involving hypomethylation of Becn1 and down-regulation of miR-30a expression. Diethylstilbestrol 57-60 beclin 1, autophagy related Mus musculus 161-166 30292723-6 2018 Curcumin activated AMPK and JNK1, which phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1, thereby promoting autophagy and alleviating apoptosis respectively. Curcumin 0-8 beclin 1, autophagy related Mus musculus 120-127 30378150-6 2018 In vivo studies indicated that 4-week administration of PAH (100 mg/kg/day) suppressed the growth of gastric cancer and increased the levels of autophagy-related proteins, including beclin-1, LC3-II, cathepsin, caspase-3, p53, and cathepsin in tumors isolated from the xenograft model of gastric cancer in mice. perillaldehyde 56-59 beclin 1, autophagy related Mus musculus 182-190 30964118-6 2019 Beclin1 and ULK1 expressions and the LC3-II/LC3-I ratio in tumor tissues were altered by rapamycin, whereas mTOR, Notch1, CD133, and CD90 expressions were significantly inhibited by rapamycin in immunofluorescence assays. Sirolimus 89-98 beclin 1, autophagy related Mus musculus 0-7 30463294-11 2018 In the ginsenoside Rg1 group, the expression of p-P70S6K, c-Jun N-terminal kinases 1 and Beclin1 declined. Ginsenosides 7-18 beclin 1, autophagy related Mus musculus 89-96 30310905-7 2018 EGCG induced autophagy concentration-dependently in 4T1 cells by modulating the levels of the autophagy-related proteins Beclin1, ATG5 and LC3B. epigallocatechin gallate 0-4 beclin 1, autophagy related Mus musculus 121-128 30349488-8 2018 Both BDNF and autophagy-associated proteins (ATG5, Beclin-1, and LC3II) were upregulated following fluoxetine treatment. Fluoxetine 99-109 beclin 1, autophagy related Mus musculus 51-59 30214523-6 2018 Compared with the control group, the expression levels of both MAP1LC3B and beclin 1 were significantly upregulated in the glutathione-treated mice, but the expression of mTOR was significantly downregulated. Glutathione 123-134 beclin 1, autophagy related Mus musculus 76-84 30214523-7 2018 It may be concluded that in the process of protecting against arecoline-induced hepatic injury, glutathione cooperates with mTOR and beclin 1 to accelerate autophagy, maintaining stable cell morphology and cellular functions. Arecoline 62-71 beclin 1, autophagy related Mus musculus 133-141 30214523-7 2018 It may be concluded that in the process of protecting against arecoline-induced hepatic injury, glutathione cooperates with mTOR and beclin 1 to accelerate autophagy, maintaining stable cell morphology and cellular functions. Glutathione 96-107 beclin 1, autophagy related Mus musculus 133-141 29752681-2 2018 Here we further studied the consequences of autophagy using glial cells of mice partially lacking the essential autophagy gene Atg6 (Beclin1) exposed to HIV Tat and morphine. Morphine 165-173 beclin 1, autophagy related Mus musculus 127-131 29752681-5 2018 Further, differences in RANTES and MCP-1 secretion between C57BL/6J and Becn1+/- glia treated with Tat and morphine also suggest a role of Beclin1 in the morphine-induced enhancement. Morphine 107-115 beclin 1, autophagy related Mus musculus 72-77 29752681-5 2018 Further, differences in RANTES and MCP-1 secretion between C57BL/6J and Becn1+/- glia treated with Tat and morphine also suggest a role of Beclin1 in the morphine-induced enhancement. Morphine 107-115 beclin 1, autophagy related Mus musculus 139-146 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. erastin 89-96 beclin 1, autophagy related Mus musculus 13-18 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. Sulfasalazine 98-111 beclin 1, autophagy related Mus musculus 13-18 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. Sorafenib 117-126 beclin 1, autophagy related Mus musculus 13-18 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. RSL3 174-178 beclin 1, autophagy related Mus musculus 13-18 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. FIN56 180-185 beclin 1, autophagy related Mus musculus 13-18 30057310-4 2018 Knockdown of BECN1 by shRNA inhibits ferroptosis induced by system Xc- inhibitors (e.g., erastin, sulfasalazine, and sorafenib), but not other ferroptosis inducers including RSL3, FIN56, and buthionine sulfoximine. Buthionine Sulfoximine 191-213 beclin 1, autophagy related Mus musculus 13-18 30131715-5 2018 The results revealed that MC-LR could induce cells apoptosis and morphologic changes in ovarian tissues, induce oxidative stress by stimulating the generation of reactive oxygen species (ROS), destroying antioxidant capacity, and subsequently trigger ERs and autophagy by inducing the hyper-expression of ATG12, ATG5, ATG16, EIF2alpha (phosphorylated at S51), CHOP, XBP1, GRP78, Beclin1, and PERK (Thr980). mc-lr 26-31 beclin 1, autophagy related Mus musculus 379-386 30131715-6 2018 Furthermore, NAC pretreatment partly inhibited MC-LR-induced ERs and autophagy via the PERK/ATG12 and XBP1/Beclin1 pathways. Acetylcysteine 13-16 beclin 1, autophagy related Mus musculus 107-114 30131715-6 2018 Furthermore, NAC pretreatment partly inhibited MC-LR-induced ERs and autophagy via the PERK/ATG12 and XBP1/Beclin1 pathways. mc-lr 47-52 beclin 1, autophagy related Mus musculus 107-114 29845241-6 2018 The results of the present study demonstrated that WSNNP treatment significantly evoked the expression of autophagy markers, including microtubule-associated light chain 3 (LC3)II/I, Beclin1 and autophagy-related 7 (ATG7), whereas the autophagy inhibitor 3-methyladenine significantly inhibited WSNNP-induced osteoblast differentiation. wsnnp 51-56 beclin 1, autophagy related Mus musculus 183-190 29935106-5 2018 Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN-induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels. Quercetin 10-19 beclin 1, autophagy related Mus musculus 130-137 30116260-5 2018 Fucosterol also inhibited apoptosis and autophagy by upregulating Bcl-2, which decreased levels of functional Bax and Beclin-1. fucosterol 0-10 beclin 1, autophagy related Mus musculus 118-126 29753783-7 2018 Further, the expression of autophagy-related genes, such as Beclin1 and LC3, were up-regulated after nicotine exposure (P < 0.05). Nicotine 101-109 beclin 1, autophagy related Mus musculus 60-67 29752681-5 2018 Further, differences in RANTES and MCP-1 secretion between C57BL/6J and Becn1+/- glia treated with Tat and morphine also suggest a role of Beclin1 in the morphine-induced enhancement. Morphine 154-162 beclin 1, autophagy related Mus musculus 72-77 29752681-5 2018 Further, differences in RANTES and MCP-1 secretion between C57BL/6J and Becn1+/- glia treated with Tat and morphine also suggest a role of Beclin1 in the morphine-induced enhancement. Morphine 154-162 beclin 1, autophagy related Mus musculus 139-146 29752681-6 2018 Analysis of autophagy maturation by immunoblot suggests that Beclin1 may be necessary for Tat, and to a lesser extent morphine-induced arrest of the pathway as demonstrated by accumulation of the adaptor protein p62/SQSTM1 in C57BL/6J glia. Morphine 118-126 beclin 1, autophagy related Mus musculus 61-68 29752681-7 2018 Calcium release induced by Tat alone or in combination with morphine in C57BL/6J glia was significantly reduced in Becn1+/- glia while minimal interactive effect of Tat with morphine in the production of reactive oxygen or nitrogen species was detected in glia derived from Becn1+/- or C57BL/6J. Calcium 0-7 beclin 1, autophagy related Mus musculus 115-120 29752681-7 2018 Calcium release induced by Tat alone or in combination with morphine in C57BL/6J glia was significantly reduced in Becn1+/- glia while minimal interactive effect of Tat with morphine in the production of reactive oxygen or nitrogen species was detected in glia derived from Becn1+/- or C57BL/6J. Calcium 0-7 beclin 1, autophagy related Mus musculus 274-279 29752681-7 2018 Calcium release induced by Tat alone or in combination with morphine in C57BL/6J glia was significantly reduced in Becn1+/- glia while minimal interactive effect of Tat with morphine in the production of reactive oxygen or nitrogen species was detected in glia derived from Becn1+/- or C57BL/6J. Morphine 60-68 beclin 1, autophagy related Mus musculus 115-120 29752681-7 2018 Calcium release induced by Tat alone or in combination with morphine in C57BL/6J glia was significantly reduced in Becn1+/- glia while minimal interactive effect of Tat with morphine in the production of reactive oxygen or nitrogen species was detected in glia derived from Becn1+/- or C57BL/6J. Morphine 60-68 beclin 1, autophagy related Mus musculus 274-279 29752681-8 2018 Overall, the data establish a role of Beclin1 in Tat and morphine-mediated inflammatory responses and calcium release in glial cells and support the notion that autophagy mediates Tat alone and combined morphine-induced neuropathology. Morphine 57-65 beclin 1, autophagy related Mus musculus 38-45 29845241-9 2018 Treatment with the MEK inhibitor U0126 significantly inhibited the protein expression levels of WSNNP-induced differentiation markers, including collagen I, RUNX2, SPP1 and ALP, and autophagy markers, including LC3II/I, Beclin1 and ATG7. U 0126 33-38 beclin 1, autophagy related Mus musculus 220-227 29845241-9 2018 Treatment with the MEK inhibitor U0126 significantly inhibited the protein expression levels of WSNNP-induced differentiation markers, including collagen I, RUNX2, SPP1 and ALP, and autophagy markers, including LC3II/I, Beclin1 and ATG7. wsnnp 96-101 beclin 1, autophagy related Mus musculus 220-227 29540788-0 2018 Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. Polyethyleneimine 105-121 beclin 1, autophagy related Mus musculus 79-86 29669822-3 2018 Therefore, the role of N-terminal arginylated BiP (R-BiP)/Beclin-1/p62 complex was examined in the crosstalk between apoptosis and autophagy during combination chemotherapy with mitomycin C and bortezomib using immunoblot, immunoprecipitation, and cellular imaging assays in wild-type (WT) and genetically engineered colorectal cancer cells. Mitomycin 178-189 beclin 1, autophagy related Mus musculus 58-66 29669822-6 2018 Mechanistically, this combination inactivated Akt and subsequently induced Beclin-1 (BECN1) dephosphorylation at Ser 234/295. Serine 113-116 beclin 1, autophagy related Mus musculus 75-83 29891447-8 2018 ATRA treatment resulted in significantly increased the expressions of autophagy-related markers LC3-II, Beclin-1, RAB7 and P62 and also an increased ratio of LC3-II/LC3-I(P<0.05). Tretinoin 0-4 beclin 1, autophagy related Mus musculus 104-112 29636885-6 2018 Moreover, puerarin pretreatment activated autophagy by increased the ratio of LC3B-II/I and the protein levels of Beclin-1, decreased the levels of p62 protein expression. puerarin 10-18 beclin 1, autophagy related Mus musculus 114-122 29669822-6 2018 Mechanistically, this combination inactivated Akt and subsequently induced Beclin-1 (BECN1) dephosphorylation at Ser 234/295. Serine 113-116 beclin 1, autophagy related Mus musculus 85-90 29540788-0 2018 Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. Polyethyleneimine 123-126 beclin 1, autophagy related Mus musculus 79-86 29551896-0 2018 Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy. calcium phosphate 81-98 beclin 1, autophagy related Mus musculus 24-32 29551896-4 2018 The objective of this study was to enhance the anticancer effect of FTY720 in hepatocellular carcinoma (HCC) by targeted co-delivery of FTY720 and Beclin 1 siRNA using calcium phosphate (CaP) nanoparticles (NPs). calcium phosphate 168-185 beclin 1, autophagy related Mus musculus 147-155 29551896-4 2018 The objective of this study was to enhance the anticancer effect of FTY720 in hepatocellular carcinoma (HCC) by targeted co-delivery of FTY720 and Beclin 1 siRNA using calcium phosphate (CaP) nanoparticles (NPs). calcium phosphate 187-190 beclin 1, autophagy related Mus musculus 147-155 29414645-9 2018 Attractively, Oroxylin A treatment also markedly up-regulated the expression of autophagy makers, LC3-B, Atg3, Atg4, Atg5, Beclin1/Atg6, Atg7, Atg9, ATG12, and Atg14, and apparently reduced the expression of autophagy substrate p62 in both CCl4-induced murine model of liver fibrosis and PDGF-BB-treated HSCs. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 14-24 beclin 1, autophagy related Mus musculus 123-130 29414645-9 2018 Attractively, Oroxylin A treatment also markedly up-regulated the expression of autophagy makers, LC3-B, Atg3, Atg4, Atg5, Beclin1/Atg6, Atg7, Atg9, ATG12, and Atg14, and apparently reduced the expression of autophagy substrate p62 in both CCl4-induced murine model of liver fibrosis and PDGF-BB-treated HSCs. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 14-24 beclin 1, autophagy related Mus musculus 131-135 29339018-7 2018 Moreover, Western blotting showed that chronic nicotine also elevated the level of autophagy makers including Beclin-1 and LC3 II triggered by CUS. Nicotine 47-55 beclin 1, autophagy related Mus musculus 110-118 29511445-5 2018 injection of streptozotocin (STZ) to develop diabetes 6 weeks before, and showed enhanced autophagy activity, seemingly through augmentation of Beclin-1 levels. Streptozocin 13-27 beclin 1, autophagy related Mus musculus 144-152 29511445-5 2018 injection of streptozotocin (STZ) to develop diabetes 6 weeks before, and showed enhanced autophagy activity, seemingly through augmentation of Beclin-1 levels. Streptozocin 29-32 beclin 1, autophagy related Mus musculus 144-152 29479301-5 2018 The overexpression of Homer1a enhanced autophagy after H2O2 treatment, which was confirmed by increased expression of LC3II, Beclin-1, and greater autophagosome formation. Hydrogen Peroxide 55-59 beclin 1, autophagy related Mus musculus 125-133 29339018-9 2018 Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1. Nicotine 17-25 beclin 1, autophagy related Mus musculus 135-143 29339018-9 2018 Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1. Corticosterone 111-125 beclin 1, autophagy related Mus musculus 135-143 29560126-8 2018 These results support that ROCK1 deficiency is cardioprotective against doxorubicin-induced cardiotoxicity at least in part through reducing Beclin 1-mediated autophagy initiation in cardiomyocytes and restoring autophagic flux to ameliorate doxorubicin cardiotoxicity. Doxorubicin 72-83 beclin 1, autophagy related Mus musculus 141-149 29339018-7 2018 Moreover, Western blotting showed that chronic nicotine also elevated the level of autophagy makers including Beclin-1 and LC3 II triggered by CUS. cupric sulfide 143-146 beclin 1, autophagy related Mus musculus 110-118 28944928-11 2017 Furthermore, hydrogen improved the deteriorated hypertrophic responses and inhibited the enhanced autophagic activity mediated by ISO administration in vivo, as indicated by decreasing HW and HW/BW, and suppressing the protein expression levels of Beclin1, Atg7 and LC3B II. Hydrogen 13-21 beclin 1, autophagy related Mus musculus 248-255 29179951-4 2018 Western blot analysis showed that the expression of autophagy-related proteins, LC3-II, Beclin-1 and Atg4 and invasion-related protein MMP-9 were upregulated in Cd-treated cells. Cadmium 161-163 beclin 1, autophagy related Mus musculus 88-96 29179951-10 2018 In addition, in lung tissues of Cd-treated BALB/c mice, the increased expression of LC3-II, Beclin-1 and Atg4 were observed. Cadmium 32-34 beclin 1, autophagy related Mus musculus 92-100 29996716-7 2018 In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice. Trehalose 27-36 beclin 1, autophagy related Mus musculus 190-195 29259100-5 2017 Inhibition of mGluR5 with CTEP also reduced the inhibitory phosphorylation of the autophagosome biogenesis-related kinase ULK1, increased the phosphorylation of the autophagy factor ATG13, and increased the abundance of the autophagy-related protein Beclin1 in homozygous zQ175 mice. 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine 26-30 beclin 1, autophagy related Mus musculus 250-257 29174851-7 2017 The expression of Bax, Bcl-2, Beclin-1, LC3, P62 and caspase 9 were markedly affected by quercetin pretreatment. Quercetin 89-98 beclin 1, autophagy related Mus musculus 30-38 29250140-8 2017 The increased expression of the autophagy-related proteins light chain 3II, beclin-1 and p62 following exposure to DMC further indicated that autophagy was activated primarily in the granulosa cells of ovarian follicles in a dose-dependent manner. methyl carbonate 115-118 beclin 1, autophagy related Mus musculus 76-84 28962872-6 2017 Caspase-mediated apoptosis by genipin and everolimus is further potentiated by the autophagy inhibitor 3-methyladenine revealing a protective role for Beclin1-mediated autophagy induced by the treatment. 3-methyladenine 103-118 beclin 1, autophagy related Mus musculus 151-158 29039471-10 2017 The outcomes of the study revealed that chronic alcohol intake results in myocardial fibrosis, enhanced myocardial collagen deposition and increased expression levels of collagen I, autophagy, autophagy-associated proteins (Beclin 1, Atg3 and Atg7) and fibrosis-associated proteins (MMP8, MMP13, MMP14, MMP17 and TGF-beta1), as well as miR-21 and miR-221. Alcohols 48-55 beclin 1, autophagy related Mus musculus 224-232 28643395-9 2017 In addition, high-glucose-induced activation of autophagic flux and apoptosis were largely attenuated by p65 siRNA, suggesting that catalase ameliorates diabetes-induced autophagy, at least in part by increasing the activity of the NF-kappaB pathway and p65-mediated transcription of BECN1. Glucose 18-25 beclin 1, autophagy related Mus musculus 284-289 28369910-4 2018 In addition, we found that ethanol induced autophagy and cardiac injury largely via the sequential triggering of reactive oxygen species (ROS) accumulation, activation of c-Jun NH2-terminal kinase (JNK), phosphorylation of Bcl-2, and dissociation of the Beclin 1/Bcl-2 complex. Ethanol 27-34 beclin 1, autophagy related Mus musculus 254-262 30504714-11 2018 Furthermore, 1,25-D3 significantly inhibited Ang II-induced autophagy dysfunction (determined by inhibition of Beclin-1 activation and reduction of the LC3-II/LC3-I ratio). Calcitriol 13-20 beclin 1, autophagy related Mus musculus 111-119 29794440-0 2018 Artesunate Attenuates Pro-Inflammatory Cytokine Release from Macrophages by Inhibiting TLR4-Mediated Autophagic Activation via the TRAF6-Beclin1-PI3KC3 Pathway. Artesunate 0-10 beclin 1, autophagy related Mus musculus 137-144 29048624-7 2017 In addition, LIQ combined with DDP significantly induce apoptosis and autophagy both in vitro and in vivo through enhancing cleavage of caspase-8/-9/-3 and PARP, as well as LC3B and Beclin 1 expression. liquiritin 13-16 beclin 1, autophagy related Mus musculus 182-190 29048624-7 2017 In addition, LIQ combined with DDP significantly induce apoptosis and autophagy both in vitro and in vivo through enhancing cleavage of caspase-8/-9/-3 and PARP, as well as LC3B and Beclin 1 expression. Cisplatin 31-34 beclin 1, autophagy related Mus musculus 182-190 29118921-6 2017 Results showed that the beneficial effects of resveratrol were related to the promotion LC3II and beclin-1 expression. Resveratrol 46-57 beclin 1, autophagy related Mus musculus 98-106 28626114-7 2017 More interestingly, the expression of autophagic markers Beclin-1 and LC3II was reduced in TSH stimulated chondrocytes, accompanied by less autophagosomes and accumulated p62 protein, indicating an impaired autophagic flux. Thyrotropin 91-94 beclin 1, autophagy related Mus musculus 57-65 29200947-6 2017 In the RGC5 cells, high-glucose stimulation upregulated the expression of LC3-II, Beclin-1, and HSPB8 in a dose-dependent manner. Glucose 24-31 beclin 1, autophagy related Mus musculus 82-90 28374157-8 2017 FKB-triggered ROS generation and ROS inhibition by NAC pre-treatment diminished FKB-induced cell death, LC3 conversion, AVO formation, p62/SQSTM1 activation, ATG4B inhibition and Beclin-1/Bcl-2 dysregulation, which indicated ROS-mediated autophagy in AGS cells. Reactive Oxygen Species 33-36 beclin 1, autophagy related Mus musculus 179-187 28374157-8 2017 FKB-triggered ROS generation and ROS inhibition by NAC pre-treatment diminished FKB-induced cell death, LC3 conversion, AVO formation, p62/SQSTM1 activation, ATG4B inhibition and Beclin-1/Bcl-2 dysregulation, which indicated ROS-mediated autophagy in AGS cells. flavokawain B 0-3 beclin 1, autophagy related Mus musculus 179-187 28374157-8 2017 FKB-triggered ROS generation and ROS inhibition by NAC pre-treatment diminished FKB-induced cell death, LC3 conversion, AVO formation, p62/SQSTM1 activation, ATG4B inhibition and Beclin-1/Bcl-2 dysregulation, which indicated ROS-mediated autophagy in AGS cells. Reactive Oxygen Species 33-36 beclin 1, autophagy related Mus musculus 179-187 29025057-6 2017 Increased levels of NQO2, reactive oxygen species (ROS), malondialdehyde (MDA), and autophagy protein Beclin1 expression were detected in oocytes cultured with ROS stimulator vitamin K3 (VK3), combined with decreased antioxidant glutathione (GSH). Reactive Oxygen Species 160-163 beclin 1, autophagy related Mus musculus 102-109 29025057-6 2017 Increased levels of NQO2, reactive oxygen species (ROS), malondialdehyde (MDA), and autophagy protein Beclin1 expression were detected in oocytes cultured with ROS stimulator vitamin K3 (VK3), combined with decreased antioxidant glutathione (GSH). Vitamin K 3 175-185 beclin 1, autophagy related Mus musculus 102-109 29025057-9 2017 Similarly, morpholino oligo-induced NQO2 knockdown suppressed ROS, MDA, and Beclin1, instead increased GSH in oocytes under VK3. Morpholinos 11-21 beclin 1, autophagy related Mus musculus 76-83 29025057-10 2017 Supplementary S29434 or melatonin limited changes in NQO2, ROS, MDA, Beclin1, and GSH during in vitro aging of ovulated oocytes, thereby maintaining spindle structure, as well as ordered chromosome separation and embryo development potential after parthenogenetic activation with SrCl2. Melatonin 24-33 beclin 1, autophagy related Mus musculus 69-76 28669590-9 2017 RESULTS: The results of Western blottings showed that TXA enhanced the production of autophagy-related proteins such as mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinase (ERK)1/2, Beclin-1, Atg12, and light chain 3 (LC3) I-II, whereas it decreased the synthesis of the mTOR complex. Tranexamic Acid 54-57 beclin 1, autophagy related Mus musculus 211-219 28745544-5 2017 We also found that Euptox A did not markedly induce splenocyte apoptosis, but induced autophagy while increasing the subcellular localization of punctate LC3, ratio of LC3-II/LC3-I, and Beclin 1 levels, and decreasing p62 levels. 9-oxo-10,11-dehydroagerophorone 19-27 beclin 1, autophagy related Mus musculus 186-194 28817115-9 2017 In vitro, CoCl2-induced hypoxia enhanced cell autophagy and affected the expression of beclin1 and BCL2/adenovirus E1B interacting protein 3 (Bnip3) in the presence of FSH. cobaltous chloride 10-15 beclin 1, autophagy related Mus musculus 87-94 28806762-7 2017 In addition to genetic activation of autophagy by Becn1 gain-of-function, we also found that ML246, a small-molecule autophagy inducer, as well as voluntary exercise, a physiological autophagy inducer, exert similar Becn1-dependent protective effects on Abeta removal and memory in AD mice. ML246 93-98 beclin 1, autophagy related Mus musculus 216-221 28872080-13 2017 Compared with the CLP group, the 7 d survival rate, lung SOD activity and the expressions of LC3B and Beclin-1 were increased significantly in the allicin treatment group (P<0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF and MDA content in the lung were decreased obviously in the allicin treatment group (P<0.05). allicin 147-154 beclin 1, autophagy related Mus musculus 102-110 28872080-14 2017 Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P<0.05). allicin 18-25 beclin 1, autophagy related Mus musculus 117-125 28872080-14 2017 Compared with the allicin treatment group, the 7 d survival rate, lung SOD activity, and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05); the lung morphological damage scores, the levels of TNF-alpha and IL-6 in the BALF, and MDA content in the lung were increased significantly in the 3-MA group (P<0.05). 3-methyladenine 148-152 beclin 1, autophagy related Mus musculus 117-125 28824162-7 2017 Autophagy markers (LC3-II and Beclin-1) were increased at the low dose of Dex (10^-7 or 10^-6 M) and decreased at the high dose (10^-5 M). Dexamethasone 74-77 beclin 1, autophagy related Mus musculus 30-38 28777810-5 2017 RESULTS: A HFD induced atherosclerosis formation and lipid metabolism disorders as well as reduced autophagy expression in the vessel wall of ApoE-knockout mice, but GTP treatment alleviated the lipid metabolism disorders, decreased the oxLDL levels in serum, and increased the mRNA and protein expressions of hepatic PPARalpha and autophagy markers (LC3, Beclin1 and p62) in the vessel wall of ApoE-knockout mice. Guanosine Triphosphate 166-169 beclin 1, autophagy related Mus musculus 356-363 28582759-9 2017 The protein expressions of LC3, LC3-II and Beclin1 increased whereas those of LC3-I and p62 decreased after treatment with alpha-mangostin. mangostin 123-138 beclin 1, autophagy related Mus musculus 43-50 28669597-7 2017 Resveratrol treatment increased Unc-51-like kinase1, Beclin1, microtubule-associated protein light chain 3, hypoxia inducible factor-1alpha, phosphorylated AMPK, collagen-2A1, Aggrecan expressions, but decreased hypoxia inducible factor-2alpha, phosphorylated mTOR, matrix metalloproteinases13 and a disintegrin and metalloproteinase with thrombospondin motifs 5 expressions. Resveratrol 0-11 beclin 1, autophagy related Mus musculus 53-60 28729825-6 2017 DEX induced expression of Bcl-1 and p62, while reduced the expression of microtubule-associated protein 1 light chain 3 (LC3) and Beclin 1 in primary cultured neurons through inhibition of apoptosis and autophagy. Dexmedetomidine 0-3 beclin 1, autophagy related Mus musculus 130-138 28624189-3 2017 Using in vitro and in vivo approaches, we found that the depletion of Mir30c and induction of BECN1 enhanced autophagy in diabetic (db/db) hearts and in cardiomyocytes treated with the fatty acid palmitate. fatty acid palmitate 185-205 beclin 1, autophagy related Mus musculus 94-99 28624177-5 2017 In contrast, light chain 3 II and beclin-1 levels were significantly less and those of cleaved caspase-3 significantly greater in the 3-methyladenine group. 3-methyladenine 134-149 beclin 1, autophagy related Mus musculus 34-42 28624189-7 2017 Similarly, Mir30c knockdown resulted in increased BECN1 levels and autophagic flux, aggravating cardiac abnormalities. mir30c 11-17 beclin 1, autophagy related Mus musculus 50-55 28450048-11 2017 Our results showed that pretreatment with liraglutide significantly prevented H2O2-induced cell viability decline, mitochondrial morphological deterioration and induction of autophagy, which appeared as increased expression of LC3 II/I and Beclin-1, along with p62 degradation. Hydrogen Peroxide 78-82 beclin 1, autophagy related Mus musculus 240-248 29221112-7 2017 In vivo studies indicated that KSP therapy (20 ml/kg/day) for two weeks suppressed the growth of gastric cancer, increased the protein levels of LC3-II, beclin-1, cathepsin L, bcl-2, p53, and capase-3 in tumor tissues from the xenograft model of mouse gastric cancer. [(1R,2S)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetic acid 31-34 beclin 1, autophagy related Mus musculus 153-161 28500326-0 2017 Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. Polyethyleneimine 86-102 beclin 1, autophagy related Mus musculus 60-67 28500326-0 2017 Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. Polyethyleneimine 104-107 beclin 1, autophagy related Mus musculus 60-67 28500326-3 2017 In the present study and for the first time, the bio-distribution and efficacy of noninvasive intranasal delivery of small interfering RNA (siRNA) against the Beclin1 gene using the cationic linear polyethylenimines (PEI) as a gene carrier was investigated in adult mouse brain. Polyethyleneimine 217-220 beclin 1, autophagy related Mus musculus 159-166 28445460-0 2017 Polyglutamine tracts regulate beclin 1-dependent autophagy. polyglutamine 0-13 beclin 1, autophagy related Mus musculus 30-38 28445460-7 2017 Here we show that the polyQ domain enables wild-type ataxin 3 to interact with beclin 1, a key initiator of autophagy. polyglutamine 22-27 beclin 1, autophagy related Mus musculus 79-87 28445460-10 2017 This activity of ataxin 3 and its polyQ-mediated interaction with beclin 1 was competed for by other soluble proteins with polyQ tracts in a length-dependent fashion. polyglutamine 34-39 beclin 1, autophagy related Mus musculus 66-74 28445460-10 2017 This activity of ataxin 3 and its polyQ-mediated interaction with beclin 1 was competed for by other soluble proteins with polyQ tracts in a length-dependent fashion. polyglutamine 123-128 beclin 1, autophagy related Mus musculus 66-74 28216619-9 2017 15d-PGJ2 pretreatment considerably suppressed the expression of Beclin-1 and LC3, thus decreasing the number of autophagosomes in the livers. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 beclin 1, autophagy related Mus musculus 64-72 28223223-4 2017 The result showed that berberine significantly improved 3xTg-AD mice"s spatial learning capacity and memory retention, promoted autophagy activity identified by the enhancement of brain LC3-II, beclin-1, hVps34, and Cathepsin-D levels as well as the reduction of brain P62 and Bcl-2 levels in AD mice, facilitated reduction of Abeta and APP levels, reduced Abeta plaque deposition in the hippocampus of AD mice, and inhibited b-site APP cleavage enzyme 1 (BACE1) expression. Berberine 23-32 beclin 1, autophagy related Mus musculus 194-202 28223223-5 2017 Similar results were also found in 3xTg-AD primary hippocampal neurons: berbernine treatment decreased the levels of extracellular and intracellular Abeta1-42, increased the protein levels of LC3-II, beclin-1, hVps34, and Cathepsin-D, and decreased the levels of P62, Bcl-2, APP and BACE1 levels. berbernine 72-82 beclin 1, autophagy related Mus musculus 200-208 28542134-3 2017 Treatment with hydrogen peroxide enhanced autophagy flux and caused the localization of BECN1 to the mitochondria, whereas these changes were impaired in the absence of CAV1. Hydrogen Peroxide 15-32 beclin 1, autophagy related Mus musculus 88-93 28542134-6 2017 Interestingly, the phosphorylation of CAV1 at tyrosine-14 was essential for the interaction with BECN1 and their localization to the mitochondria, and the activation of autophagy in response to hydrogen peroxide. Tyrosine 46-54 beclin 1, autophagy related Mus musculus 97-102 28542134-6 2017 Interestingly, the phosphorylation of CAV1 at tyrosine-14 was essential for the interaction with BECN1 and their localization to the mitochondria, and the activation of autophagy in response to hydrogen peroxide. Hydrogen Peroxide 194-211 beclin 1, autophagy related Mus musculus 97-102 27782356-9 2017 Simvastatin increases autophagy-related protein Atg5, LC3B and Beclin1 expression and autophagosome formation in lung tissue. Simvastatin 0-11 beclin 1, autophagy related Mus musculus 63-70 28382029-8 2017 Ba induced autophagy by increasing the expression of Beclin1 and Atg5-Atg12-Atg16 complex, but not the AKT/mTOR signaling pathway. Barium 0-2 beclin 1, autophagy related Mus musculus 53-60 28070729-7 2017 Co-treatment with CI radiation and CQ could block autophagy through the IRE1/JNK/Beclin-1 axis and enhance apoptotic cell death via the activation of C/EBP homologous protein (CHOP) by the IRE1 pathway rather than PERK in vitro and in vivo. Chloroquine 35-37 beclin 1, autophagy related Mus musculus 81-89 28025107-7 2017 RESULTS: 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. Fluorouracil 9-13 beclin 1, autophagy related Mus musculus 78-109 28081732-8 2017 Interestingly, we demonstrated that miR-17-5p could directly target beclin-1 via luciferase gene reporter assay. mir-17-5p 36-45 beclin 1, autophagy related Mus musculus 68-76 27887947-7 2017 Furthermore, berberine significantly increased the high glucose-elevated Unc-51-like autophagy-activating kinase 1 (ULK1) S317/S555 phosphorylation, Beclin-1 expression, the ratios of LC3II to LC3I expression and the numbers of autophagosomes, but reduced ULK1 S757 phosphorylation in podocytes. Berberine 13-22 beclin 1, autophagy related Mus musculus 149-157 27770734-12 2016 LC3 II/I ratio and Beclin1 and Atg4B expressions were down-regulated (P all <0.05) but p62 expression was significantly increased (P<0.05) in the presence of SO2 both in vivo and in vitro. Sulfur Dioxide 164-167 beclin 1, autophagy related Mus musculus 19-26 27590234-7 2016 In addition, resveratrol inhibited the expression of the Beclin1 protein in mouse lungs. Resveratrol 13-24 beclin 1, autophagy related Mus musculus 57-64 27999666-0 2016 Beclin-1- mediated autophagy may be involved in the elderly cognitive and affective disorders in streptozotocin-induced diabetic mice. Streptozocin 97-111 beclin 1, autophagy related Mus musculus 0-8 27999666-23 2016 Beclin1 mediated autophagy in hippocampus probably played an important role in cognitive and affective disorders of STZ-induced aged diabetic mice. Streptozocin 116-119 beclin 1, autophagy related Mus musculus 0-7 27737765-0 2016 beta-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy. asarone 0-12 beclin 1, autophagy related Mus musculus 144-152 27737765-13 2016 In addition, beta-asarone treatment reduced AChE and Abeta42 levels, increased p-mTOR and p62 expression, decreased p-Akt, Beclin-1, and LC3B expression, decreased the number of autophagosomes and reduced APP mRNA and Beclin-1 mRNA levels compared with the untreated group. asarone 13-25 beclin 1, autophagy related Mus musculus 123-131 27737765-13 2016 In addition, beta-asarone treatment reduced AChE and Abeta42 levels, increased p-mTOR and p62 expression, decreased p-Akt, Beclin-1, and LC3B expression, decreased the number of autophagosomes and reduced APP mRNA and Beclin-1 mRNA levels compared with the untreated group. asarone 13-25 beclin 1, autophagy related Mus musculus 218-226 27737765-14 2016 That is, beta-asarone treatment can improve the learning and memory abilities of APP/PS1 transgenic mouse by inhibiting Beclin-1-dependent autophagy via the PI3K/Akt/mTOR pathway. asarone 9-21 beclin 1, autophagy related Mus musculus 120-128 27590234-8 2016 The presented findings collectively suggest that resveratrol has a therapeutic effect on mouse LC-induced COPD, and its mechanism of action might be related to reducing the production of the Beclin1 protein. Resveratrol 49-60 beclin 1, autophagy related Mus musculus 191-198 27567859-8 2016 In N2a cells, we also found that OLE potentiates the MNNG-induced increase of Beclin1 levels. oleuropein aglycone 33-36 beclin 1, autophagy related Mus musculus 78-85 27793014-7 2016 Moreover, DHM exerted hepatoprotective effects by upregulating mRNA levels of various essential autophagy-related genes including ATG5, ATG12, BECN1, and LC3. dihydromyricetin 10-13 beclin 1, autophagy related Mus musculus 143-148 27343376-8 2016 Additionally, U0126 remarkable reduced the level of Beclin-1 and LC3 and increased p62 expression, which indicates that U0126 suppressed H/R-induced autophagy. U 0126 14-19 beclin 1, autophagy related Mus musculus 52-60 27343376-8 2016 Additionally, U0126 remarkable reduced the level of Beclin-1 and LC3 and increased p62 expression, which indicates that U0126 suppressed H/R-induced autophagy. U 0126 120-125 beclin 1, autophagy related Mus musculus 52-60 27343376-8 2016 Additionally, U0126 remarkable reduced the level of Beclin-1 and LC3 and increased p62 expression, which indicates that U0126 suppressed H/R-induced autophagy. r 139-140 beclin 1, autophagy related Mus musculus 52-60 27565383-5 2016 Carfilzomib also produces an increase in the formation of autophagosomes but, as apoptosis progresses, autophagy is disrupted, probably owing to Beclin 1 and p62 inactivation. carfilzomib 0-11 beclin 1, autophagy related Mus musculus 145-153 26964766-11 2016 Simultaneously, both in vivo and in vitro, 3-MA significantly decreased the expression of LC3-II and Beclin-1, and maintained p62 at high level after ICH. 3-methyladenine 43-47 beclin 1, autophagy related Mus musculus 101-109 27317636-7 2016 Additionally, we demonstrated that HS induced autophagy, including increased LC3B and Beclin-1 expression and decreased phosphorylation of mTOR and Stat3, as well as phosphorylation of ERK. hassio 35-37 beclin 1, autophagy related Mus musculus 86-94 27430408-8 2016 Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate. Vitamin D 13-22 beclin 1, autophagy related Mus musculus 71-79 27605908-6 2016 Our results showed that TTC treatment reduced the expression of autophagy markers (Becn1, Atg5, Lc3, and p62) and pro-apoptotic genes such as Bax and Casp3 in spinal cord. 6-thiotheophylline 24-27 beclin 1, autophagy related Mus musculus 83-88 27154061-10 2016 Notably, ADRB2 signaling negatively regulated autophagy by disrupting Beclin1/VPS34/Atg14 complex in an Akt-dependent manner, leading to HIF1alpha stabilization, reprogramming of HCC cells glucose metabolism, and the acquisition of resistance to sorafenib. Sorafenib 246-255 beclin 1, autophagy related Mus musculus 70-77 27605885-4 2016 RESULTS: LC3-II, p62, and Run domain Beclin-1 interacting and cysteine-rich containing (Rubicon) proteins increased in both the HFD mice and in AML12 cells in response to PA treatment. Palmitates 171-173 beclin 1, autophagy related Mus musculus 37-45 27239411-11 2016 Beclin-1 protein levels were increased by bortezomib treatment in Day 3 controls but were unchanged on both Days 3 and 7 in the AH-130 hosts, suggesting that an early compensatory induction of autophagy may exist in healthy but not in tumour-bearing animals. Bortezomib 42-52 beclin 1, autophagy related Mus musculus 0-8 26456737-3 2016 Rapamycin induced and altered the expression of autophagy signature proteins in wild-type cultures as well as in HT22-Beclin-1-knockdown cells. Sirolimus 0-9 beclin 1, autophagy related Mus musculus 118-126 27494711-2 2016 The previous study showed cilostazol modulates autophagy by increasing beclin1, Atg5 and LC3-II expressions, and depletes intracellular Abeta accumulation. Cilostazol 26-36 beclin 1, autophagy related Mus musculus 71-78 27037187-7 2016 However 25 and 50mg/kg CQ treatment significantly decreased the CS-induced autophagosomes (p=0.0505; p=0.0065) and attenuated the effects of CS on LC3B and BECN1 expression. Chloroquine 23-25 beclin 1, autophagy related Mus musculus 156-161 27037187-7 2016 However 25 and 50mg/kg CQ treatment significantly decreased the CS-induced autophagosomes (p=0.0505; p=0.0065) and attenuated the effects of CS on LC3B and BECN1 expression. Cesium 141-143 beclin 1, autophagy related Mus musculus 156-161 27058414-8 2016 Map1LC3B and Beclin1 were significantly over-expressed in HepG2 xenografts in nude mice treated with panobinostat for 4 weeks. Panobinostat 101-113 beclin 1, autophagy related Mus musculus 13-20 27335569-4 2016 Inverted phase contrast microscope images, MTT assay, flow cytometry and western blot results showed that, compared to cells exposed to 100 microM H2O2 alone, cells pretreated with methylprednisolone had a significantly lower percentage of apoptotic cells, maintained a healthy morphology, and showed downregulation of autophagic protein light chain 3B and Beclin-1 protein expression. Hydrogen Peroxide 147-151 beclin 1, autophagy related Mus musculus 357-365 26994142-4 2016 Here we identify Ser-90 in Beclin 1 as a regulatory site whose phosphorylation is markedly enhanced in cells treated with okadaic acid, an inhibitor of protein phosphatase 2A (PP2A). Serine 17-20 beclin 1, autophagy related Mus musculus 27-35 26994142-4 2016 Here we identify Ser-90 in Beclin 1 as a regulatory site whose phosphorylation is markedly enhanced in cells treated with okadaic acid, an inhibitor of protein phosphatase 2A (PP2A). Okadaic Acid 122-134 beclin 1, autophagy related Mus musculus 27-35 26994142-5 2016 Beclin 1 Ser-90 phosphorylation is induced in skeletal muscle tissues isolated from starved mice. Serine 9-12 beclin 1, autophagy related Mus musculus 0-8 26994142-8 2016 We also found that death-associated protein kinase 3 directly phosphorylates Beclin 1 Ser-90. Serine 86-89 beclin 1, autophagy related Mus musculus 77-85 26994142-9 2016 We propose that physiological regulation of Beclin 1 Ser-90 phosphorylation by PP2A and death-associated protein kinase 3 controls autophagy. Serine 53-56 beclin 1, autophagy related Mus musculus 44-52 27335569-4 2016 Inverted phase contrast microscope images, MTT assay, flow cytometry and western blot results showed that, compared to cells exposed to 100 microM H2O2 alone, cells pretreated with methylprednisolone had a significantly lower percentage of apoptotic cells, maintained a healthy morphology, and showed downregulation of autophagic protein light chain 3B and Beclin-1 protein expression. Methylprednisolone 181-199 beclin 1, autophagy related Mus musculus 357-365 26984939-10 2016 Beclin 1(+/-) mice exposed to doxorubicin were protected in terms of structural and functional changes within the myocardium. Doxorubicin 30-41 beclin 1, autophagy related Mus musculus 0-8 27070930-5 2016 Our results show that ethanol induces overexpression of several autophagy markers (ATG12, LC3-II, CTSB), and increases the number of lysosomes in WT astrocytes, effects accompanied by a basification of lysosomal pH and by lowered phosphorylation levels of autophagy inhibitor mTOR, along with activation of complexes beclin-1 and ULK1. Ethanol 22-29 beclin 1, autophagy related Mus musculus 317-325 27158352-0 2016 Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis. CHEMBL3740941 42-44 beclin 1, autophagy related Mus musculus 65-73 27017485-10 2016 Furthermore, systemic administration of the miR-141 knock-down the expression of HMGB1 protein and further antagonized the downstream protein Beclin-1, leading to the reduction of autophagosomes and autolysosomes, blockade of the LC3-II level and the increased levels of p62 protein after injection of l-arginine. Arginine 302-312 beclin 1, autophagy related Mus musculus 142-150 26414319-7 2016 RESULTS: Our data showed that AEE promoted kinetophagy flux (an increase in LC3-II to LC3-I ratio and LC3-II levels and a reduction in p62 levels) with Beclin-1 levels suppressed but Atg7 levels elevated compared with those in the sedentary group. aspirin eugenol ester 30-33 beclin 1, autophagy related Mus musculus 152-160 26260377-5 2015 Further exploration found that tBHQ treatment significantly increased the expression of Beclin-1 and the ratio of microtubule-associated protein 1 light chain 3 (LC3)-II to LC3-I, suggesting that autophagy was enhanced after tBHQ treatment. 2-tert-butylhydroquinone 31-35 beclin 1, autophagy related Mus musculus 88-96 26503303-4 2015 The expression of LC3 I, II, Beclin-1 and p62 were increased in the cerebellum of STZ-treated wild-type mice, and these expressions were more increased in STZ-treated fat-1 mice, but not of p62. Streptozocin 82-85 beclin 1, autophagy related Mus musculus 29-37 26527331-8 2015 In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group. Thioguanine 105-107 beclin 1, autophagy related Mus musculus 31-39 26527331-8 2015 In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group. Thioguanine 143-145 beclin 1, autophagy related Mus musculus 31-39 26527331-8 2015 In addition, the expression of Beclin-1 protein involved in autophagosome formation was increased in the Tg-TE group compared with that in the Tg-CON group, whereas that of p62 protein was reduced in the Tg-TE group compared with that in the Tg-CON group. Thioguanine 143-145 beclin 1, autophagy related Mus musculus 31-39 26593251-6 2016 We also showed that inhibition of PDK1 with DAP increased the cleavage of pro-apoptotic proteins (PARP and Caspase 3) and decreased the expression of the anti-apoptotic proteins (BCL-xL and BCL-2) and autophagy regulators (ULK1, Beclin-1 and Atg). 2,2-dichloroacetophenone 44-47 beclin 1, autophagy related Mus musculus 229-237 26501338-11 2015 The 3-MA treatment decreased levels of Beclin-1 and Atg 7 but increased levels of p62 in the ethanol-fed WT and KI mice whereas rapamycin had the opposite effects, validating inhibition and stimulation of autophagy, respectively. 3-methyladenine 4-8 beclin 1, autophagy related Mus musculus 39-47 25882498-7 2015 LC3-II and beclin-1 expression peaked 12-24h after exposing podocytes to high glucose. Glucose 78-85 beclin 1, autophagy related Mus musculus 11-19 26004523-7 2015 The beneficial effect of berberine is associated with inhibiting the cellular autophagy level, due to decreasing the expression level of autophagy-related proteins such as SIRT1, BNIP3, and Beclin-1. Berberine 25-34 beclin 1, autophagy related Mus musculus 190-198 26244661-2 2015 We previously found that cilostazol induced SIRT1 expression and its activity in neuronal cells, and thus, we hypothesized that cilostazol might stimulate clearances of Abeta and C-terminal APP fragment beta subunit (APP-CTFbeta) by up-regulating autophagy.When N2a cells were exposed to soluble Abeta1-42, protein levels of beclin-1, autophagy-related protein5 (Atg5), and SIRT1 decreased significantly. Cilostazol 128-138 beclin 1, autophagy related Mus musculus 325-333 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Palmitates 27-36 beclin 1, autophagy related Mus musculus 173-181 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Palmitates 27-36 beclin 1, autophagy related Mus musculus 183-188 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Fatty Acids 0-21 beclin 1, autophagy related Mus musculus 173-181 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Palmitates 38-40 beclin 1, autophagy related Mus musculus 173-181 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Fatty Acids 0-21 beclin 1, autophagy related Mus musculus 183-188 26098646-2 2015 Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Palmitates 38-40 beclin 1, autophagy related Mus musculus 183-188 26098646-3 2015 Conversely, unsaturated fatty acids like oleate (OL) promote non-canonical, PIK3C3- and BECN1-independent autophagy. Fatty Acids, Unsaturated 12-35 beclin 1, autophagy related Mus musculus 88-93 26098646-3 2015 Conversely, unsaturated fatty acids like oleate (OL) promote non-canonical, PIK3C3- and BECN1-independent autophagy. Oleic Acid 41-47 beclin 1, autophagy related Mus musculus 88-93 26098646-3 2015 Conversely, unsaturated fatty acids like oleate (OL) promote non-canonical, PIK3C3- and BECN1-independent autophagy. Oleic Acid 49-51 beclin 1, autophagy related Mus musculus 88-93 25896938-0 2015 Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury. cobaltous chloride 45-50 beclin 1, autophagy related Mus musculus 14-22 25966641-8 2015 P188 suppressed the activation of autophagy by decreasing LC3-II and Beclin-1 levels under OGD accordingly. Poloxamer 0-4 beclin 1, autophagy related Mus musculus 69-77 26380026-12 2015 The expression of Beclin1, LC3 and cathepsin B was decreased in the HC group, and increased in the CR group. Chromium 99-101 beclin 1, autophagy related Mus musculus 18-25 26237833-0 2015 Tetrahydroxy stilbene glucoside improved the behavioral disorders of APP695V717I transgenic mice by inhibiting the expression of Beclin-1 and LC3-II. 2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside 0-31 beclin 1, autophagy related Mus musculus 129-137 26237833-1 2015 OBJECTIVE: To observe the effect of tetrahydroxy stilbene glucoside (TSG) on the behavior of APP695V717I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1 and LC3-II. 2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside 69-72 beclin 1, autophagy related Mus musculus 181-189 26237833-7 2015 RESULTS: The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency, greater swimming distance, less time taken to cross the exact former platform location in the model group, and increased mRNA and protein expressions of Beclin-1 and LC3-II compared with the control group (P < 0.05). Water 88-93 beclin 1, autophagy related Mus musculus 290-298 26237833-9 2015 CONCLUSION: these results indicate that tetrahydroxy stilbene glucoside can decrease expressions of Beclin-1 and LC3-II in the autophagy pathway. 2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside 40-71 beclin 1, autophagy related Mus musculus 100-108 25663172-5 2015 Key proteins involved in initiating autophagy, such as beclin-1, and several Atg proteins involved in autophagosome maturation (Atg3, Atg5, Atg12 and Atg7), were also up-regulated on exposure to HDHA. hdha 195-199 beclin 1, autophagy related Mus musculus 55-63 26043790-8 2015 In vivo validation of these findings demonstrated increased expression of BECN1, ATG5, and MAP1LC3B-II proteins in cocaine-treated mouse brains compared to untreated animals. Cocaine 115-122 beclin 1, autophagy related Mus musculus 74-79 25825934-4 2015 It was found that SS-12 commonly interacts with Bcl-2 and Beclin 1 BH3 domain proteins and enhances autophagic flux by modulating autophagy-related proteins. CHEMBL3422548 18-23 beclin 1, autophagy related Mus musculus 58-66 25647735-8 2015 In addition, CQ plus RES synergistically decreased the levels of both autophagy initiator beclin-1 and autophagy supporter p62. Chloroquine 13-15 beclin 1, autophagy related Mus musculus 90-98 25365634-5 2015 Furthermore, VDR activation significantly inhibited MI/R-induced autophagy dysfunction (determined by the inhibition of Beclin 1 over-activation, the reduction of autophagosomes, the LC3-II/LC3-I ratio, p62 protein abundance, and the restoration of autophagy flux). r 15-16 beclin 1, autophagy related Mus musculus 120-128 25646672-2 2015 We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy. Progesterone 94-106 beclin 1, autophagy related Mus musculus 59-64 25646672-2 2015 We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy. Progesterone 94-106 beclin 1, autophagy related Mus musculus 65-73 25646672-2 2015 We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy. Progesterone 160-172 beclin 1, autophagy related Mus musculus 59-64 25646672-2 2015 We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy. Progesterone 160-172 beclin 1, autophagy related Mus musculus 65-73 25646672-4 2015 BECN1 is necessary for the interaction of the 2 catalytic subunits of the class III phosphatidylinositol 3-kinase complex, PIK3C3, and PIK3R4, which are responsible for the generation of phosphatidylinositol 3-phosphate that is required for nucleation of the phagophore. Phosphatidylinositols 84-104 beclin 1, autophagy related Mus musculus 0-5 25646672-4 2015 BECN1 is necessary for the interaction of the 2 catalytic subunits of the class III phosphatidylinositol 3-kinase complex, PIK3C3, and PIK3R4, which are responsible for the generation of phosphatidylinositol 3-phosphate that is required for nucleation of the phagophore. phosphatidylinositol 3-phosphate 187-219 beclin 1, autophagy related Mus musculus 0-5 25646672-10 2015 Thus, this study provides evidence that Becn1 is necessary for steroid production in murine luteal cells. Steroids 63-70 beclin 1, autophagy related Mus musculus 40-45 25249228-7 2015 Our study demonstrated that telmisartan dose-dependently increased the expression of beclin-1, the LC3II/LC3I ratio and the quantity of GFP-labeled autophagosomes, displaying a peak effect at 10 muM. Telmisartan 28-39 beclin 1, autophagy related Mus musculus 85-93 25895672-8 2015 H2O2 highly enhanced the expression induction of the autophagy-related beclin-1 and light chains 3A/B (LC3A/B) within 4 h and astragalin blocked such induction by H2O2. Hydrogen Peroxide 0-4 beclin 1, autophagy related Mus musculus 71-79 25895672-8 2015 H2O2 highly enhanced the expression induction of the autophagy-related beclin-1 and light chains 3A/B (LC3A/B) within 4 h and astragalin blocked such induction by H2O2. Hydrogen Peroxide 163-167 beclin 1, autophagy related Mus musculus 71-79 25895672-10 2015 Consistently, in OVA-sensitized mice the expression of beclin-1 and LC3A/B was highly induced, and oral administration of astragalin suppressed the autophagosome formation with inhibiting the induction of these proteins in OVA-challenged airway subepithelium. astragalin 122-132 beclin 1, autophagy related Mus musculus 55-63 25773147-6 2015 The protective effect of 1,25(OH)2D3 was associated with significantly elevated expression of Beclin1, increased Bcl-2/Bax ratio, and decreased LC3-II accumulation. Calcitriol 25-36 beclin 1, autophagy related Mus musculus 94-101 25501647-6 2015 In addition, CRS resulted in increase of lipid peroxidation levels and reduction of the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and increase of autophagy markers (microtubule-associated proteins, light chain 3-II, LC3-II, and Beclin-1) in mice skin. 3-cresol 13-16 beclin 1, autophagy related Mus musculus 263-271 25457681-6 2015 In colon 26 (C26) cells, SNO-HSA significantly suppressed hypoxia-induced autophagy by inhibiting the phosphorylation of JNK1 and the expression of its downstream molecule Beclin1. Altretamine 29-32 beclin 1, autophagy related Mus musculus 172-179 25211624-4 2015 Furthermore, PBTD (RS2778)-induced autophagic cell death was verified by LC3-II conversion, and upregulation of Beclin-1 and ATG5. pbtd 13-17 beclin 1, autophagy related Mus musculus 112-120 25351979-6 2015 Notably, treatment of the cells with simvastatin elevated ox-LDL-induced macrophage autophagy, this was detected through the conversion of LC3 I to LC3 II and the increased expression of Beclin1, another autophagy marker. Simvastatin 37-48 beclin 1, autophagy related Mus musculus 187-194 25715028-3 2015 Here we report that the BH3 mimetic, ABT-737, induces autophagy in parallel with disruption of BCL2-BECN1 binding in 2 different apoptosis-deficient cell types lacking BAX and BAK1, namely in mouse embryonic fibroblasts cells and in human colon cancer HCT116 cells. BH 3 24-27 beclin 1, autophagy related Mus musculus 100-105 25715028-3 2015 Here we report that the BH3 mimetic, ABT-737, induces autophagy in parallel with disruption of BCL2-BECN1 binding in 2 different apoptosis-deficient cell types lacking BAX and BAK1, namely in mouse embryonic fibroblasts cells and in human colon cancer HCT116 cells. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 37-40 beclin 1, autophagy related Mus musculus 100-105 25821351-5 2015 Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1. Acetylcysteine 14-17 beclin 1, autophagy related Mus musculus 102-110 24631516-0 2014 Madecassoside prevents Abeta(25-35)-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway. madecassoside 0-13 beclin 1, autophagy related Mus musculus 126-134 25224042-6 2014 However, promotion of autophagy with either a pharmacologic inducer (rapamycin) or the Beclin-1 overexpressing technique rescued the cell apoptosis and reduced the reactive oxygen species level in the cells. Reactive Oxygen Species 164-187 beclin 1, autophagy related Mus musculus 87-95 24733562-4 2014 During OC differentiation, Beclin-1 localized to the mitochondria, where it was involved in the production of mitochondrial intracellular reactive oxygen species. Reactive Oxygen Species 138-161 beclin 1, autophagy related Mus musculus 27-35 24733562-6 2014 Furthermore, knockdown of Beclin-1 inhibited RANKL-mediated activation of JNK and p38, both of which act downstream of reactive oxygen species, resulting in the suppression of NFATc1 induction. Reactive Oxygen Species 119-142 beclin 1, autophagy related Mus musculus 26-34 24733562-8 2014 These findings show that Beclin-1 plays a non-autophagic role in RANKL-induced osteoclastogenesis by inducing the production of reactive oxygen species and NFATc1. Reactive Oxygen Species 128-151 beclin 1, autophagy related Mus musculus 25-33 24928515-9 2014 Beclin 1 knockdown abolished preconditioning-induced autophagy, and SPK2 inhibitors abolished isoflurane-induced disruption of the Beclin 1/Bcl-2 association. Isoflurane 94-104 beclin 1, autophagy related Mus musculus 131-139 25246579-5 2014 We find that pregnant females lacking Becn1 in the ovarian granulosa cell population have a defect in progesterone production and a subsequent preterm labor phenotype. Progesterone 102-114 beclin 1, autophagy related Mus musculus 38-43 25126729-0 2014 Berberine attenuates autophagy in adipocytes by targeting BECN1. Berberine 0-9 beclin 1, autophagy related Mus musculus 58-63 25126729-5 2014 We also show that berberine, a natural plant alkaloid, inhibits basal autophagy in adipocytes and adipose tissue of mice fed a high-fat diet via downregulation of BECN1 expression. Berberine 18-27 beclin 1, autophagy related Mus musculus 163-168 25126729-6 2014 We further demonstrate that berberine has a pronounced effect on the stability of Becn 1 mRNA through the Mir30 family. Berberine 28-37 beclin 1, autophagy related Mus musculus 82-88 25264893-12 2014 Western blotting analysis showed that the expression levels of Beclin 1 and LC3 were significantly decreased in NAC-treated mice. Acetylcysteine 112-115 beclin 1, autophagy related Mus musculus 63-71 24917047-9 2014 Moreover, the EVOO-enriched diet improved the muscle status as shown by expression of myogenic factors (Myod1 and Myog) and autophagy markers (LC3 and Beclin1), as well as diminished endoplasmic reticulum (ER) stress through decreasing Atf6 and Grp78. evoo 14-18 beclin 1, autophagy related Mus musculus 151-158 25068516-7 2014 Further studies by TEM (Transmission electron microscopy) analysis, GFP-LC3-II puncta formation assay and western blot for LC3-II, Beclin1 and Atg 7, showed that resveratrol induces autophagy in BCSCs. Resveratrol 162-173 beclin 1, autophagy related Mus musculus 131-138 25024814-20 2014 However, in mice fed diet + DOC + CGA (with reduced frequency of cancer) and evaluated for ERCC1, beclin-1, and beta-catenin in the stem cell region of crypts, mouse tissue showed amelioration of the aberrancies, suggesting that chlorogenic acid is protective at the molecular level against colon cancer. Deoxycholic Acid 28-31 beclin 1, autophagy related Mus musculus 98-106 24126417-11 2013 Immunoblotting and fluorometric analysis showed that CBZ blocked calpain activation, depletion of Atg7 and Beclin-1 and loss of autophagic flux after reperfusion. Carbamazepine 53-56 beclin 1, autophagy related Mus musculus 107-115 24751948-7 2014 By the use of small hairpin RNAs and chemical inhibitors, we further demonstrated that zVAD-induced autophagy requires not only RIP1, RIP3, PI3KC3 and Beclin-1, but also RGS19 and GNAI3, and this autophagy is required for zVAD-induced TNF production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 87-91 beclin 1, autophagy related Mus musculus 151-159 24466346-5 2014 Immunoblotting results showed that H2S pretreatment reversed TBI-induced cleavage of caspase-3 and decline of Bcl-2, suppressed LC3-II, Beclin-1 and Vps34 activation and maintained p62 level in injured cortex and hippocampus post TBI. Hydrogen Sulfide 35-38 beclin 1, autophagy related Mus musculus 136-144 23971531-0 2014 Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Carbon Monoxide 0-15 beclin 1, autophagy related Mus musculus 58-66 23737395-12 2013 It is Atg5 rather than BECN1 that plays a crucial role in UA-induced autophagic cell death in TC-1 cells. ursolic acid 58-60 beclin 1, autophagy related Mus musculus 23-28 24126417-13 2013 In conclusion, CBZ prevents calcium overloading and calpain activation, which, in turn, suppresses Atg7 and Beclin-1 depletion, defective autophagy, onset of the MPT and cell death after I/R. Carbamazepine 15-18 beclin 1, autophagy related Mus musculus 108-116 24632846-9 2014 Furthermore, treatment with aldosterone significantly increased the conversion of LC3-I to LC3-II, beclin-1 expression and autophagosome formation. Aldosterone 28-39 beclin 1, autophagy related Mus musculus 99-107 24337465-4 2014 In the current studies, we determined the mechanisms of nilotinib-induced parkin-beclin-1 interaction, which leads to amyloid clearance. nilotinib 56-65 beclin 1, autophagy related Mus musculus 81-89 24337465-5 2014 Nilotinib increased endogenous parkin levels and ubiquitination, which may enhance parkin recycling via the proteasome, leading to increased activity and interaction with beclin-1. nilotinib 0-9 beclin 1, autophagy related Mus musculus 171-179 24337465-8 2014 These results suggest that nilotinib boosts the autophagic machinery, leading to increased level of endogenous parkin that undergoes ubiquitination and interacts with beclin-1 to facilitate amyloid clearance. nilotinib 27-36 beclin 1, autophagy related Mus musculus 167-175 24477711-6 2014 We observed limited induction of heat-shock proteins with treatment, but found evidence that 17-DMAG may be acting through autophagy, as LC3-II (both at mRNA and protein levels) and beclin-1 were induced in the brain of treated animals. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 93-100 beclin 1, autophagy related Mus musculus 182-190 24401596-6 2014 Autophagy-impaired (Becn1(+/-), map1lc3b(-/-), or Hdac6(-/Y)) mice resist CS-induced cilia shortening. Cesium 74-76 beclin 1, autophagy related Mus musculus 20-25 24466263-10 2014 Our data showed that a decreased sequestosome 1 (SQSTM1/p62) level, an increased Beclin-1 level, and higher ratio of LC3-II/LC3-I were observed in ND RIPostC group, but not DM RIPostC group. ripostc 150-157 beclin 1, autophagy related Mus musculus 81-89 25551567-6 2014 The treatment of mice with olanzapine for 14 d increased the brain levels of autophagosome-associated LC3B-II and mRNA encoding Atg4b, Atg5, Atg7, Atg12, Gabarap, and Becn1. Olanzapine 27-37 beclin 1, autophagy related Mus musculus 167-172 23644913-7 2013 RESULTS: Chronic administration of trehalose resulted in a reduction of frontal cortex p62/beclin-1 ratio suggesting enhancement of autophagy. Trehalose 35-44 beclin 1, autophagy related Mus musculus 91-99 24200693-3 2013 Autophagy-impaired (Becn1+/- or Map1lc3B-/-) mice and MTECs resisted CS-induced cilia shortening. Cesium 69-71 beclin 1, autophagy related Mus musculus 20-25 24200693-7 2013 Autophagy-impaired Becn1-/-, Map1lc3B-/-, and Hdac6-/Y mice or mice injected with an HDAC6 inhibitor were protected from CS-induced mucociliary clearance (MCC) disruption. Cesium 121-123 beclin 1, autophagy related Mus musculus 19-24 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 15-19 beclin 1, autophagy related Mus musculus 72-80 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 15-19 beclin 1, autophagy related Mus musculus 229-237 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 186-190 beclin 1, autophagy related Mus musculus 72-80 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 186-190 beclin 1, autophagy related Mus musculus 229-237 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 186-190 beclin 1, autophagy related Mus musculus 72-80 24085658-5 2013 We showed that 3-NP-induced apoptosis, which was accompanied by Bax and Beclin-1 upregulation, was dependent on acidic vesicular organelle (AVO) formation after a continuous exposure to 3-NP for 12 h. The upregulation of Bax and Beclin-1 as well as AVO formation were normalized 24 h after 3-NP exposure. 3-nitropropionic acid 186-190 beclin 1, autophagy related Mus musculus 229-237 22874563-3 2012 We have demonstrated that human and mouse CF airways are autophagy deficient due to functional sequestration of BECN1 and that the tissue transglutaminase-2 inhibitor, cystamine, or antioxidants restore BECN1-dependent autophagy and reduce SQSTM1/p62 levels, thus favoring DeltaF508-CFTR trafficking to the epithelial surface. Cystamine 168-177 beclin 1, autophagy related Mus musculus 112-117 23851366-10 2013 At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5. Trehalose 26-35 beclin 1, autophagy related Mus musculus 162-167 23505001-8 2013 Further studies showed that expressions of Beclin 1 and LC3beta required in autophagy development were significantly upregulated by resveratrol but not by vitamin C. Resveratrol 132-143 beclin 1, autophagy related Mus musculus 43-51 23461901-9 2013 Inhibition of autophagy, either with chloroquine or by downregulation of beclin1 or of ATG5, enhanced sensitivity to oxaliplatin under normal and hypoxic conditions in a synergistic manner. Oxaliplatin 117-128 beclin 1, autophagy related Mus musculus 73-80 23503475-6 2013 RESULTS: Both in SH-SY5Y cells and in the midbrain of UPS-impaired mouse model of PD, treatment with lactacystin significantly increased the expression levels of LC3-I/II and Beclin 1, and reduced the levels of p-mTOR, mTOR and p62/SQSTM1. lactacystin 101-112 beclin 1, autophagy related Mus musculus 175-183 23503475-8 2013 CONCLUSION: Inhibition of UPS by lactacystin in dopaminergic neurons activates another protein degradation system, the ALP, which includes both the mTOR signaling pathway and Beclin 1-associated pathway. lactacystin 33-44 beclin 1, autophagy related Mus musculus 175-183 23223177-4 2013 Conversely, activation of AMPK by metformin stimulated JNK1-Bcl-2 signaling and disrupted the Beclin1-Bcl-2 complex. Metformin 34-43 beclin 1, autophagy related Mus musculus 94-101 23223177-7 2013 Finally, chronic administration of metformin in diabetic mice restored cardiac autophagy by activating JNK1-Bcl-2 pathways and dissociating Beclin1 and Bcl-2. Metformin 35-44 beclin 1, autophagy related Mus musculus 140-147 24133573-5 2013 AE did not induce apoptotic cell death, but did significantly increase the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. ae 0-2 beclin 1, autophagy related Mus musculus 113-120 24133573-6 2013 Quercetin also increased the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. Quercetin 0-9 beclin 1, autophagy related Mus musculus 67-74 24133573-8 2013 AE acted synergistically with cisplatin to reduce cell proliferation and increase expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions. Cisplatin 30-39 beclin 1, autophagy related Mus musculus 120-127 23737459-5 2013 Isolation of autophagic vacuoles (AVs) in AD mouse brain shows accumulation of parkin and amyloid, consistent with previous results in AD brains, while Bosutinib and Nilotinib increase parkin-Beclin-1 interaction and result in protein deposition in the lysosome. bosutinib 152-161 beclin 1, autophagy related Mus musculus 192-200 23737459-5 2013 Isolation of autophagic vacuoles (AVs) in AD mouse brain shows accumulation of parkin and amyloid, consistent with previous results in AD brains, while Bosutinib and Nilotinib increase parkin-Beclin-1 interaction and result in protein deposition in the lysosome. nilotinib 166-175 beclin 1, autophagy related Mus musculus 192-200 23801739-6 2013 Furthermore, in agreement with the improvements observed in motor function beclin 1 overexpression prevented neuronal dysfunction and neurodegeneration, decreasing formation of polyglutamine-expanded aggregates, preserving Purkinje cell arborization and immunoreactivity for neuronal markers. polyglutamine 177-190 beclin 1, autophagy related Mus musculus 75-83 23569248-2 2013 Activity of the class III phosphatidylinositol-3-OH-kinase (PI3K) vacuolar protein-sorting (Vps) 34, bound to coiled-coil moesin-like B-cell lymphoma 2 (Bcl-2)-interacting protein Beclin-1, is required for phosphoinositide generation, essential for AV formation in autophagy [Cuervo AM (2010) Nat Cell Biol 12(8):735-737]. Phosphatidylinositols 206-222 beclin 1, autophagy related Mus musculus 180-188 24453420-8 2013 The expression of Bcl-2, Bax, Beclin-1, and LC3, which play an important role in the regulation of intrinsic pathway of apoptosis and autophagy, was also obviously decreased by ethyl pyruvate (80 mg/kg). ethyl pyruvate 177-191 beclin 1, autophagy related Mus musculus 30-38 24453420-10 2013 CONCLUSION: Our results showed that ethyl pyruvate might attenuate to hepatic I/R injury by inhibiting intrinsic pathway of apoptosis and autophagy, mediated partly through downregulation of HMGB1/TLR4/ NF-kappab axis and the competitive interaction with Beclin-1 of HMGB1. ethyl pyruvate 36-50 beclin 1, autophagy related Mus musculus 255-263 22444502-12 2012 Last but not least, CR significantly promoted cardiac autophagy as evidenced by increased expression of LC3B-II (and LC3B-II to LC3B-I ratio) and Beclin-1. Chromium 20-22 beclin 1, autophagy related Mus musculus 146-154 22874563-3 2012 We have demonstrated that human and mouse CF airways are autophagy deficient due to functional sequestration of BECN1 and that the tissue transglutaminase-2 inhibitor, cystamine, or antioxidants restore BECN1-dependent autophagy and reduce SQSTM1/p62 levels, thus favoring DeltaF508-CFTR trafficking to the epithelial surface. Cystamine 168-177 beclin 1, autophagy related Mus musculus 203-208 22896037-4 2012 This study demonstrated that autophagy proteins beclin-1, Atg5, and Atg12 were cleaved and degraded during the course of cisplatin injury in RTEC and the kidney. Cisplatin 121-130 beclin 1, autophagy related Mus musculus 48-56 22819980-4 2012 Autophagy was impaired in ethanol-treated KI mice compared to KO mice as reflected by a decline in the LC3-II/LC3-I ratio and lower total LC-3 and Beclin-1 levels coupled to increases in P62, pAKT/AKT and mTOR. Ethanol 26-33 beclin 1, autophagy related Mus musculus 147-155 22847295-5 2012 Furthermore, GA-DM treatment initiated a possible cross-talk between autophagy and apoptosis as evidenced by increased levels of Beclin-1 and LC3 proteins, and their timely interplay with apoptotic and/or anti-apoptotic molecules in melanoma cells. 3,7-dioxolanosta-8,24-dien-26-oic acid 13-18 beclin 1, autophagy related Mus musculus 129-137 22582971-5 2012 Melatonin induced a significant increase in expression of the microtubule-associated protein 1 light chain 3 (LC3)-II and Beclin-1 proteins in a dose-dependent manner. Melatonin 0-9 beclin 1, autophagy related Mus musculus 122-130 22343142-1 2012 Nutrient-deprivation autophagy factor-1 (NAF-1) was identified as an endoplasmic reticulum (ER) BCL-2-interacting protein, which functions to mediate the ability of ER BCL-2 to antagonize Beclin 1-dependent autophagy and depress ER calcium stores. Calcium 232-239 beclin 1, autophagy related Mus musculus 188-196 22790389-8 2012 RESULTS: CsA treatment increased the expressions of LC3-II and beclin-1 in the kidney in a dose-dependent manner. Cyclosporine 9-12 beclin 1, autophagy related Mus musculus 63-71 22843615-5 2012 After sensitizing the lungs with radiation, beclin1, complexed with a nano-sized biodegradable poly(ester amine), was prepared and delivered into the murine lung via aerosol three times/week for four weeks. poly(caprolactone-block-ethyleneimine) 95-112 beclin 1, autophagy related Mus musculus 44-51 22157765-0 2012 MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. Cisplatin 39-51 beclin 1, autophagy related Mus musculus 68-76 22157765-3 2012 First, the autophagy activity in cancer cells increased after cis-dichloro-diamine platinum (cis-DDP) or Taxol treatment, as indicated by the enhanced expression of beclin 1, a key regulator of autophagy, and increased number of LC3-positive autophagosomes. Cisplatin 62-91 beclin 1, autophagy related Mus musculus 165-173 22157765-3 2012 First, the autophagy activity in cancer cells increased after cis-dichloro-diamine platinum (cis-DDP) or Taxol treatment, as indicated by the enhanced expression of beclin 1, a key regulator of autophagy, and increased number of LC3-positive autophagosomes. Cisplatin 93-100 beclin 1, autophagy related Mus musculus 165-173 22157765-3 2012 First, the autophagy activity in cancer cells increased after cis-dichloro-diamine platinum (cis-DDP) or Taxol treatment, as indicated by the enhanced expression of beclin 1, a key regulator of autophagy, and increased number of LC3-positive autophagosomes. Paclitaxel 105-110 beclin 1, autophagy related Mus musculus 165-173 22157765-4 2012 Second, miRNA screening using a TaqMan probe-based quantitative RT-PCR assay identified that miR-30a, a miRNA that targets beclin 1, was significantly reduced in tumor cells by cis-DDP treatment. Cisplatin 177-184 beclin 1, autophagy related Mus musculus 123-131 22157765-8 2012 In conclusion, our results demonstrate for the first time that miR-30a can sensitize tumor cells to cis-DDP via reducing beclin 1-mediated autophagy and that increasing miR-30a level in tumor cells represents a novel approach to enhance the efficacy of chemotherapy during cancer treatment. Cisplatin 100-107 beclin 1, autophagy related Mus musculus 121-129 22724008-8 2012 Finally, glutamate activated autophagy markers Beclin 1 and LC3-II, while selenium prevented the activation. Glutamic Acid 9-18 beclin 1, autophagy related Mus musculus 47-55 23056421-11 2012 MGO increased endothelial LC3B and Beclin-1, markers of autophagy, which were accompanied by an increase of both autophagic flux (LC3 punctae) and co-immunoprecipitation of VEGFR2 with LC3. Pyruvaldehyde 0-3 beclin 1, autophagy related Mus musculus 35-43 22003194-8 2012 An increased number of autophagosomes in granulosa cells of ovarian follicles together with increased expression of Beclin-1 and microtubule-associated protein light chain 3, key regulatory proteins in the autophagy (Atg) pathway, was found in CS-exposed mice compared with the control group. Cesium 244-246 beclin 1, autophagy related Mus musculus 116-173 22222116-5 2012 We found that melatonin triggers an autophagic process by enhancing Beclin 1 expression and inducing a conversion of microtubule-associated protein 1 light chain 3(LC3)-I to LC3-II, the protein associated with the autophagosome membrane, in hepatoma H22 tumor-bearing mice. Melatonin 14-23 beclin 1, autophagy related Mus musculus 68-76 22222116-7 2012 Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells. 3-methyladenine 95-110 beclin 1, autophagy related Mus musculus 13-21 22222116-7 2012 Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells. 3-methyladenine 111-115 beclin 1, autophagy related Mus musculus 13-21 22222116-7 2012 Knockdown of Beclin 1 by either RNA interference or co-treatment with the autophagy inhibitor, 3-methyladenine(3-MA), significantly enhanced the melatonin-induced apoptosis in mouse hepatoma H22 cells. Melatonin 145-154 beclin 1, autophagy related Mus musculus 13-21 21067284-0 2011 Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Hydrogen Peroxide 0-17 beclin 1, autophagy related Mus musculus 26-34 21672589-9 2011 Immunoprecipitation also revealed dissociation of the Bcl-2/Beclin1 complex in PINK1-silenced cells, which was reversed by additional treatment with C2-ceramide, and correlated with changes in level of autophagy and S87 phosphorylation of Bcl-2. N-acetylsphingosine 149-160 beclin 1, autophagy related Mus musculus 60-67 21822295-8 2011 Finally, knockdown of Beclin 1 decreased LH-stimulated StAR expression and testosterone production in TM3 mouse Leydig cells, which were associated with increased intracellular ROS level. Testosterone 75-87 beclin 1, autophagy related Mus musculus 22-30 21822295-8 2011 Finally, knockdown of Beclin 1 decreased LH-stimulated StAR expression and testosterone production in TM3 mouse Leydig cells, which were associated with increased intracellular ROS level. Reactive Oxygen Species 177-180 beclin 1, autophagy related Mus musculus 22-30 21856859-6 2011 Subsequent studies revealed that palmitic acid-induced apoptosis suppressed autophagy by inducing caspase-dependent Beclin 1 cleavage, indicating cross-talk between apoptosis and autophagy. Palmitic Acid 33-46 beclin 1, autophagy related Mus musculus 116-124 21463664-7 2011 Immunoblotting analysis showed that 3-MA pretreatment reduced post-TBI Beclin-1 and LC3-II levels, and maintained p62/SQSTM1 (p62) levels. 3-methyladenine 36-40 beclin 1, autophagy related Mus musculus 71-79 21067284-0 2011 Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Glutathione 161-164 beclin 1, autophagy related Mus musculus 26-34 21067284-2 2011 Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection. Glutathione 6-9 beclin 1, autophagy related Mus musculus 317-325 21067284-2 2011 Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection. Hydrogen Peroxide 31-35 beclin 1, autophagy related Mus musculus 317-325 21067284-2 2011 Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection. bafilomycin 191-202 beclin 1, autophagy related Mus musculus 317-325 21067284-5 2011 Collectively, these findings demonstrate that H2O2 induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Hydrogen Peroxide 46-50 beclin 1, autophagy related Mus musculus 59-67 21067284-5 2011 Collectively, these findings demonstrate that H2O2 induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Glutathione 194-197 beclin 1, autophagy related Mus musculus 59-67 20711182-5 2010 Restoration of beclin 1 and autophagy by either beclin 1 overexpression, cystamine or antioxidants rescues the localization of the beclin 1 interactome to the endoplasmic reticulum and reverts the CF airway phenotype in vitro, in vivo in Scnn1b-transgenic and Cftr(F508del) homozygous mice, and in human CF nasal biopsies. Cystamine 73-82 beclin 1, autophagy related Mus musculus 15-23 20930278-4 2011 In MC65 cells, 48-72-hour treatment with phytic acid provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Abeta oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein. Phytic Acid 41-52 beclin 1, autophagy related Mus musculus 319-327 20977678-7 2010 Three subunits of the class III PI3K complex (Beclin 1, UVRAG and BIF-1) have been independently identified as tumour suppressors in mice and humans, and their mechanism of action in this context has been proposed to entail activation of autophagy, a catabolic pathway that is considered to mediate tumour suppression by scavenging damaged organelles that would otherwise cause DNA instability through the production of reactive oxygen species. Reactive Oxygen Species 420-443 beclin 1, autophagy related Mus musculus 46-54 21074548-3 2011 Within 24h of 50 muM cisPt administration, C2C12 myotubes displayed unchanged cell viability but showed a subset of hallmark signs typically recognized during atrophy, including severe reduction in body size, repression of Akt phosphorylation, transcriptional up-regulation of atrophy-related genes, such as atrogin-1, gabarap, beclin-1 and bnip-3, and loss of myogenic markers. Cisplatin 21-26 beclin 1, autophagy related Mus musculus 328-336 20431342-5 2010 First, we confirmed zVAD can stimulate LC3 cleavage, beclin 1 gene expression, autophagosome formation, and ROS accumulation in L929 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 20-24 beclin 1, autophagy related Mus musculus 53-61 19289499-6 2009 Finally, anti-CD3- and PMA-ionomycin-mediated activation of T-cell receptor signaling in peripheral T cells from lymph nodes of healthy mice results in an upregulation of BECN1 expression that can be blocked by the NF-kappaB inhibitor BAY 11-7082. Ionomycin 27-36 beclin 1, autophagy related Mus musculus 171-176 20155447-6 2010 Besides, the protein levels of LC3II and Beclin1 were remarkably increased in ischemia/reperfusion-injured N2a in the presence of melatonin, whereas the expression of p-PKB, key kinase in PI3K/PKB signaling pathway, showed a decrease when compared with untreated subjects as accessed by immunoblotting. Melatonin 130-139 beclin 1, autophagy related Mus musculus 41-48 19289499-6 2009 Finally, anti-CD3- and PMA-ionomycin-mediated activation of T-cell receptor signaling in peripheral T cells from lymph nodes of healthy mice results in an upregulation of BECN1 expression that can be blocked by the NF-kappaB inhibitor BAY 11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 235-246 beclin 1, autophagy related Mus musculus 171-176 19202353-4 2009 In addition, oridonin induced autophagy in L929 cells, and the inhibition of autophagy by 3-MA or siRNA against LC3 and beclin 1 promoted oridonin-induced apoptosis. oridonin 138-146 beclin 1, autophagy related Mus musculus 120-128 19270693-3 2009 Combining mouse genetics and biochemistry, we have identified a large in vivo Beclin 1 complex containing the known proteins Vps34, p150/Vps15 and UVRAG, as well as two newly identified proteins, Atg14L (yeast Atg14-like) and Rubicon (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein). Cysteine 250-258 beclin 1, autophagy related Mus musculus 78-86 19187231-5 2009 Further data confirmed that oridonin also induced L929 cell autophagy, as demonstrated by extensive autophagic vacuolization and the punctuate distribution of monodansylcadaverine staining and GFP-LC3, as well as the LC3-II/LC3-I proportion and Beclin 1 activation. oridonin 28-36 beclin 1, autophagy related Mus musculus 245-253 19187231-6 2009 Subsequently, we found that inhibition of autophagy by 3-methyladenine or small interfering RNA against LC3 and Beclin 1 promoted oridonin-induced cell apoptosis. oridonin 130-138 beclin 1, autophagy related Mus musculus 112-120 18635920-5 2008 The expression of autophagy-associated Beclin 1 protein was up-regulated, and microtubule-associated protein light chain 3 I (LC3 I) was cleaved into LC3 II after 80 microM PAB treatment from 12 h. Therefore, it was concluded that PAB exerted a cytostatic effect on L929 cells through autophagy. pseudolaric acid B 173-176 beclin 1, autophagy related Mus musculus 39-47 18635920-5 2008 The expression of autophagy-associated Beclin 1 protein was up-regulated, and microtubule-associated protein light chain 3 I (LC3 I) was cleaved into LC3 II after 80 microM PAB treatment from 12 h. Therefore, it was concluded that PAB exerted a cytostatic effect on L929 cells through autophagy. pseudolaric acid B 231-234 beclin 1, autophagy related Mus musculus 39-47 18635920-8 2008 Immunoprecipitation analysis showed that PAB inhibited Bcl-2 binding with Beclin 1. pseudolaric acid B 41-44 beclin 1, autophagy related Mus musculus 74-82 18635920-11 2008 Therefore the phosphorylation of Bcl-2 in the cytoplasm and the mitochondrial location of Bcl-2 might be the reasons why PAB inhibited the binding of Bcl-2 and Beclin 1. pseudolaric acid B 121-124 beclin 1, autophagy related Mus musculus 160-168 17959603-5 2008 Treatment with C(2)-ceramide was associated with both the cleavage of caspase-3 and poly(ADP-ribose) polymerase and the degradation of autophagy-related Beclin 1 and Atg5 proteins, without a change in the cyclin-CDK activity, which culminated in apoptosis in p21(+/+) mouse embryonic fibroblasts (MEFs). N-acetylsphingosine 15-28 beclin 1, autophagy related Mus musculus 153-161 17959603-6 2008 On the other hand, C(2)-ceramide did not cleave caspase-3 or poly(ADP-ribose) polymerase and kept Beclin 1 and Atg5 proteins stable in p21(-/-) MEFs, events that this time culminated in autophagy. N-acetylsphingosine 19-32 beclin 1, autophagy related Mus musculus 98-106 17959603-7 2008 When expression of the p21 protein was inhibited by small interfering RNA or when the overexpression of Beclin 1 or Atg5 was induced, autophagy rather than apoptosis was initiated in the p21(+/+) MEFs treated with C(2)-ceramide. N-acetylsphingosine 214-227 beclin 1, autophagy related Mus musculus 104-112 17959603-8 2008 In contrast, the exogenous expression of p21 or the silencing of Beclin 1 and Atg5 with small interfering RNA increased the number of apoptotic cells and decreased the number of autophagic cells among C(2)-ceramide-treated p21(-/-) MEFs. Ceramides 206-214 beclin 1, autophagy related Mus musculus 65-73 15558033-5 2004 This non-apoptotic death of double knockout cells was suppressed by inhibitors of autophagy, including 3-methyl adenine, was dependent on autophagic proteins APG5 and Beclin 1 (capable of binding to Bcl-2/Bcl-x(L)), and was also modulated by Bcl-x(L). 3-methyladenine 103-119 beclin 1, autophagy related Mus musculus 167-175 18253089-6 2008 Consistently, induction of autophagy by serum starvation offered significant protection against zVAD-induced cell death, whereas knockdown of Atg5, Atg7 or Beclin 1 markedly sensitized zVAD-induced cell death in L929 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 185-189 beclin 1, autophagy related Mus musculus 156-164