PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34722538-3	2021	Drp1 is a target for SUMOylation and its deSUMOylation, mediated by the SUMO protease SENP3, enhances the Drp1-Mff interaction to promote cell death in an oxygen/glucose deprivation (OGD) model of ischemia.	Oxygen	155-161	SUMO specific peptidase 3	Homo sapiens	86-91
1534115-2	1992	They bear on their plasma membrane a sialic acid-containing epitope (Ssp-3) defined by a series of monoclonal antibodies (mAbs).	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	69-74
1712251-3	1991	This enzyme specifically transfers alpha (2-3)-linked sialic acid from extrinsic host-derived macromolecules to parasite surface molecules, leading to the assembly of Ssp-3, a trypomastigote-specific epitope.	N-Acetylneuraminic Acid	54-65	SUMO specific peptidase 3	Homo sapiens	167-172
1712251-5	1991	Monoclonal antibodies that recognize sialic acid residues of Ssp-3 inhibit attachment of trypomastigotes to host cells, suggesting that the unusual trans-sialidase provides Ssp-3 with structural features required for target cell recognition.	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	61-66
1712251-5	1991	Monoclonal antibodies that recognize sialic acid residues of Ssp-3 inhibit attachment of trypomastigotes to host cells, suggesting that the unusual trans-sialidase provides Ssp-3 with structural features required for target cell recognition.	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	173-178
34662529-9	2021	However, ROS do exhibit some inhibitory effects on autophagy through direct oxidation of key autophagy regulators such as ATG3, ATG7 and SENP3 proteins.	Reactive Oxygen Species	9-12	SUMO specific peptidase 3	Homo sapiens	137-142
34000626-7	2021	FINDINGS: SENP3 was highly expressed in VSMCs of remodeled arteries, accompanied by elevated reactive oxygen species (ROS) levels.	Reactive Oxygen Species	93-116	SUMO specific peptidase 3	Homo sapiens	10-15
34312671-0	2021	Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BioID assay.	Diethylnitrosamine	69-87	SUMO specific peptidase 3	Homo sapiens	14-19
34249943-3	2021	Here, we reported that there was an increase in ROS level and SENP3 expression in Dex-induced osteoporotic BM-MSCs, and enhanced adipogenesis and weakened osteogenesis in osteoporotic BM-MSCs might be caused by upregulated SENP3.	Dextromethorphan	82-85	SUMO specific peptidase 3	Homo sapiens	62-67
34249943-3	2021	Here, we reported that there was an increase in ROS level and SENP3 expression in Dex-induced osteoporotic BM-MSCs, and enhanced adipogenesis and weakened osteogenesis in osteoporotic BM-MSCs might be caused by upregulated SENP3.	Dextromethorphan	82-85	SUMO specific peptidase 3	Homo sapiens	223-228
35489496-6	2022	The resulting emission scenarios show widely diverging trends of increased emissions by 240% for ibuprofen in SSP3 (regional rivalry) to a 68% decrease for diclofenac in SSP1 (sustainable development) by 2050.	Ibuprofen	97-106	SUMO specific peptidase 3	Homo sapiens	110-114
35074361-7	2022	In contrast, the gap of higher MDA8 ozone concentrations in suburban-rural than urban areas increases under SSP3-7.0 concomitant with increase in anthropogenic emissions.	Ozone	36-41	SUMO specific peptidase 3	Homo sapiens	108-112
35408798-0	2022	EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AML.	imidazoquinoxaline	13-31	SUMO specific peptidase 3	Homo sapiens	53-58
35408798-12	2022	EAPB0503-induced NPM1c SUMOylation is concurrent with SENP3 downregulation and ARF upregulation in NPM1c expressing cells.	EAPB0503	0-8	SUMO specific peptidase 3	Homo sapiens	54-59
34994490-5	2022	We find that DFP treatment leads to the stabilization of the SUMO protease SENP3, which is mediated by downregulation of the E3 ubiquitin (Ub) ligase CHIP.	Deferiprone	13-16	SUMO specific peptidase 3	Homo sapiens	75-80
34994490-6	2022	SENP3 is responsible for Fis1 deSUMOylation and depletion of SENP3 abolishes DFP-induced mitophagy.	Deferiprone	77-80	SUMO specific peptidase 3	Homo sapiens	61-66
34994490-8	2022	Critically, expressing a Fis1 K149R mutant restores DFP-induced mitophagy in SENP3-depleted cells.	Deferiprone	52-55	SUMO specific peptidase 3	Homo sapiens	77-82
33736148-14	2021	However, this study strongly recommends future "plausible world" regional rivalry pathways (SSP3) scenario-combinations into consideration for policymaking in regard to water management as well as migration planning over South Asia.	Water	169-174	SUMO specific peptidase 3	Homo sapiens	92-96
34000626-7	2021	FINDINGS: SENP3 was highly expressed in VSMCs of remodeled arteries, accompanied by elevated reactive oxygen species (ROS) levels.	Reactive Oxygen Species	118-121	SUMO specific peptidase 3	Homo sapiens	10-15
34000626-8	2021	In cultured VSMCs, SENP3 protein levels were enhanced by oxidized low-density lipoprotein and Angiotensin II in a ROS-dependent manner.	Reactive Oxygen Species	114-117	SUMO specific peptidase 3	Homo sapiens	19-24
33231124-8	2020	SENP3 knockdown attenuated the high glucose-induced intercellular adhesion of THP-1 monocytic cells and HAECs via downregulation of ICAM-1 and VCAM-1 expression.	Glucose	36-43	SUMO specific peptidase 3	Homo sapiens	0-5
33434504-5	2021	Consistently, SENP3 senses ROS to facilitate STING-dependent DC activity in tissue samples from colorectal cancer patients.	Reactive Oxygen Species	27-30	SUMO specific peptidase 3	Homo sapiens	14-19
33732350-8	2021	SUMO specific protease 3 (SENP3), which inhibits the binding of SUMO2/3 to its target proteins, was overexpressed and it was discovered that isoflurane-induced SUMOylation was significantly inhibited, and accordingly, the proliferation and invasion abilities of HCC cells were decreased to a certain extent.	Isoflurane	141-151	SUMO specific peptidase 3	Homo sapiens	26-31
31293646-0	2019	Nuclear Nrf2 Activity in Laryngeal Carcinoma is Regulated by SENP3 After Cisplatin-Induced Reactive Oxygen Species Stress.	Cisplatin	73-82	SUMO specific peptidase 3	Homo sapiens	61-66
32728594-4	2020	Our results show that population under water stress is expected to increase by 50% under a low population growth and emissions scenario (SSP1-RCP2.6) and double under a high population growth and emission scenario (SSP3-RCP6.0), compared to the year 2010.	Water	39-44	SUMO specific peptidase 3	Homo sapiens	215-219
31744695-4	2020	Our results show that the largest climate change damages occur under the SSP3-7.0 scenario (involving regional rivalry and high anthropogenic emissions), followed by the SSP3-LowNTCF scenario (which considers significantly reduced NTCF emissions), and that climate change damage costs are expected to grow much faster than global GDP (reaching ~47% of global GDP in 2100).	Guanosine Diphosphate	330-333	SUMO specific peptidase 3	Homo sapiens	73-77
31744695-4	2020	Our results show that the largest climate change damages occur under the SSP3-7.0 scenario (involving regional rivalry and high anthropogenic emissions), followed by the SSP3-LowNTCF scenario (which considers significantly reduced NTCF emissions), and that climate change damage costs are expected to grow much faster than global GDP (reaching ~47% of global GDP in 2100).	Guanosine Diphosphate	359-362	SUMO specific peptidase 3	Homo sapiens	73-77
31293646-0	2019	Nuclear Nrf2 Activity in Laryngeal Carcinoma is Regulated by SENP3 After Cisplatin-Induced Reactive Oxygen Species Stress.	Reactive Oxygen Species	91-114	SUMO specific peptidase 3	Homo sapiens	61-66
31293646-6	2019	Cisplatin exposure induced ROS stress in Hep-2 cells in a time-dependent manner and was accompanied by increased Nrf2 and SENP3 protein accumulations, an effect reversed by the addition of the antioxidant N-acetyl-cysteine (NAC).	Cisplatin	0-9	SUMO specific peptidase 3	Homo sapiens	122-127
31293646-6	2019	Cisplatin exposure induced ROS stress in Hep-2 cells in a time-dependent manner and was accompanied by increased Nrf2 and SENP3 protein accumulations, an effect reversed by the addition of the antioxidant N-acetyl-cysteine (NAC).	Acetylcysteine	205-222	SUMO specific peptidase 3	Homo sapiens	122-127
31293646-9	2019	Our data identified intranuclear activation of Nrf2 is triggered by cisplatin-induced ROS development through the activity of SENP3.	Cisplatin	68-77	SUMO specific peptidase 3	Homo sapiens	126-131
31293646-9	2019	Our data identified intranuclear activation of Nrf2 is triggered by cisplatin-induced ROS development through the activity of SENP3.	Reactive Oxygen Species	86-89	SUMO specific peptidase 3	Homo sapiens	126-131
30089837-5	2018	Notably, SENP3 accumulation triggered by reactive oxygen species (ROS) is involved in Treg cell-mediated tumor immunosuppression.	Reactive Oxygen Species	41-64	SUMO specific peptidase 3	Homo sapiens	9-14
30089837-5	2018	Notably, SENP3 accumulation triggered by reactive oxygen species (ROS) is involved in Treg cell-mediated tumor immunosuppression.	Reactive Oxygen Species	66-69	SUMO specific peptidase 3	Homo sapiens	9-14
30089837-6	2018	Our results not only establish the role of SENP3 in the maintenance of Treg cell stability and function via BACH2 deSUMOylation but also clarify the function of SENP3 in the regulation of ROS-induced immune tolerance.	Reactive Oxygen Species	188-191	SUMO specific peptidase 3	Homo sapiens	161-166
28432497-0	2017	Immobilization of Ulp1 protease on NHS-activated Sepharose: a useful tool for cleavage of the SUMO tag of recombinant proteins.	Sepharose	49-58	SUMO specific peptidase 3	Homo sapiens	18-22
30136521-1	2018	A novel analytical method was developed for the determination of organic acids (formic acid, acetic acid and propionic acid) in 1, 2-butylene oxide (1, 2-BO) products by valve switch-ion chromatography (IC).The samples were diluted in ethanol, and then were eluted from a concentrator column (IonPac TAC-ULP1) to an analytical column (IonPac AS11).The extracts were detected by a suppressed conductivity detector.Formic acid, acetic acid and propionic acid were separated well.Good linear relationships for the three organic acids were obtained.The spiked recoveries of the three organic acids in the samples were in the range of 92.5%-111.8%.The relative standard deviations (RSDs) were less than 5.6%(n=3).The limits of detection (LODs, S/N=3) of the formic acid, acetic acid and propionic acid were 0.60-4.80 mug/L.The method is simple, rapid, and accurate, and is suitable for the determination of the organic acids in an insoluble organic system.	organic acids	65-78	SUMO specific peptidase 3	Homo sapiens	300-308
30136521-1	2018	A novel analytical method was developed for the determination of organic acids (formic acid, acetic acid and propionic acid) in 1, 2-butylene oxide (1, 2-BO) products by valve switch-ion chromatography (IC).The samples were diluted in ethanol, and then were eluted from a concentrator column (IonPac TAC-ULP1) to an analytical column (IonPac AS11).The extracts were detected by a suppressed conductivity detector.Formic acid, acetic acid and propionic acid were separated well.Good linear relationships for the three organic acids were obtained.The spiked recoveries of the three organic acids in the samples were in the range of 92.5%-111.8%.The relative standard deviations (RSDs) were less than 5.6%(n=3).The limits of detection (LODs, S/N=3) of the formic acid, acetic acid and propionic acid were 0.60-4.80 mug/L.The method is simple, rapid, and accurate, and is suitable for the determination of the organic acids in an insoluble organic system.	1,2-epoxybutane	128-147	SUMO specific peptidase 3	Homo sapiens	300-308
28432497-2	2017	RESULTS: We immobilized Ulp1 on N-hydroxysuccinimide (NHS)-activated Sepharose with a coupling efficiency of 1.7 mg/ml.	N-hydroxysuccinimide	32-52	SUMO specific peptidase 3	Homo sapiens	24-28
28432497-2	2017	RESULTS: We immobilized Ulp1 on N-hydroxysuccinimide (NHS)-activated Sepharose with a coupling efficiency of 1.7 mg/ml.	N-hydroxysuccinimide	54-57	SUMO specific peptidase 3	Homo sapiens	24-28
28432497-2	2017	RESULTS: We immobilized Ulp1 on N-hydroxysuccinimide (NHS)-activated Sepharose with a coupling efficiency of 1.7 mg/ml.	Sepharose	69-78	SUMO specific peptidase 3	Homo sapiens	24-28
28432497-4	2017	Besides resistance against some small molecules, the immobilized Ulp1 can tolerate 15% (v/v) DMSO and 20% (v/v) ethanol.	Dimethyl Sulfoxide	93-97	SUMO specific peptidase 3	Homo sapiens	65-69
28432497-4	2017	Besides resistance against some small molecules, the immobilized Ulp1 can tolerate 15% (v/v) DMSO and 20% (v/v) ethanol.	Ethanol	112-119	SUMO specific peptidase 3	Homo sapiens	65-69
28321049-0	2017	Protective effect of SENP3-mediated SUMOylation against cadmium toxicity.	Cadmium	56-63	SUMO specific peptidase 3	Homo sapiens	21-26
25288641-7	2014	We define an N-terminal domain in SENP3 as the critical NPM1 binding region and provide evidence that mTOR-mediated phosphorylation of serine/threonine residues within this region fosters the interaction of SENP3 with NPM1.	Serine	135-141	SUMO specific peptidase 3	Homo sapiens	34-39
28747610-0	2017	Retraction: Protective effect of SENP3-mediated SUMOylation against cadmium toxicity.	Cadmium	68-75	SUMO specific peptidase 3	Homo sapiens	33-38
27853276-3	2016	Our results showed that hepatic SENP3 was up-regulated in NAFLD patients and an animal model in vivo and after loading hepatocytes with free fatty acids (FFA) in vitro.	Fatty Acids, Nonesterified	136-152	SUMO specific peptidase 3	Homo sapiens	32-37
27853276-3	2016	Our results showed that hepatic SENP3 was up-regulated in NAFLD patients and an animal model in vivo and after loading hepatocytes with free fatty acids (FFA) in vitro.	Fatty Acids, Nonesterified	154-157	SUMO specific peptidase 3	Homo sapiens	32-37
27087120-11	2016	Quercetin acts to increase survival in the face of ischemia via an increase of SENP3 expression, the possible inactivation of SENPs 1/2, and via a decrease in KEAP1 levels (thereby increasing Nrf2 stability).	Quercetin	0-9	SUMO specific peptidase 3	Homo sapiens	79-84
27181202-3	2016	We demonstrated that exposure of HNC cell lines to a tobacco extract induced a rapid Y705 phosphorylation of STAT3 and a rapid increase in the SUMO protease SENP3 that depended on a simultaneous increase in reactive oxygen species.	Reactive Oxygen Species	207-230	SUMO specific peptidase 3	Homo sapiens	157-162
25288641-7	2014	We define an N-terminal domain in SENP3 as the critical NPM1 binding region and provide evidence that mTOR-mediated phosphorylation of serine/threonine residues within this region fosters the interaction of SENP3 with NPM1.	Serine	135-141	SUMO specific peptidase 3	Homo sapiens	207-212
25288641-7	2014	We define an N-terminal domain in SENP3 as the critical NPM1 binding region and provide evidence that mTOR-mediated phosphorylation of serine/threonine residues within this region fosters the interaction of SENP3 with NPM1.	Threonine	142-151	SUMO specific peptidase 3	Homo sapiens	34-39
25288641-7	2014	We define an N-terminal domain in SENP3 as the critical NPM1 binding region and provide evidence that mTOR-mediated phosphorylation of serine/threonine residues within this region fosters the interaction of SENP3 with NPM1.	Threonine	142-151	SUMO specific peptidase 3	Homo sapiens	207-212
20181954-3	2010	Here, we show that low doses of hydrogen peroxide (H(2)O(2)) induce an increase of the SENP3 protein, which removes SUMO2/3 from promyelocytic leukemia (PML).	Hydrogen Peroxide	32-49	SUMO specific peptidase 3	Homo sapiens	87-92
23524851-2	2013	Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the unfolded protein response (UPR) kinase PERK and the lysosomal enzyme cathepsin B.	Oxygen	82-88	SUMO specific peptidase 3	Homo sapiens	57-62
20945481-4	2010	The fusion protein was purified by Ni-NTA affinity chromatography and cleaved by a SUMO-specific protease (Ulp1) to obtain the recombinant AGAP (rAGAP), which was further purified by Ni-NTA affinity chromatography.	agap	139-143	SUMO specific peptidase 3	Homo sapiens	107-111
20459100-1	2010	Several copper-indium bimetallic single-source precursors (SSPs 2-9) have been prepared efficiently by exchange reactions of (Ph(3)P)(2)CuIn(SEt)(4) (1) with protic ligands.	Copper	8-14	SUMO specific peptidase 3	Homo sapiens	59-67
20459100-1	2010	Several copper-indium bimetallic single-source precursors (SSPs 2-9) have been prepared efficiently by exchange reactions of (Ph(3)P)(2)CuIn(SEt)(4) (1) with protic ligands.	Indium	15-21	SUMO specific peptidase 3	Homo sapiens	59-67
25216525-8	2014	Additionally, reactive oxygen species-induced de-SUMOylation of FOXC2 can be blocked by silencing endogenous SENP3.	Reactive Oxygen Species	14-37	SUMO specific peptidase 3	Homo sapiens	109-114
23467634-4	2013	The expression of SENP3 was higher in OSCC tissues than that in the normal mucosa adjacent to the tumor, and a modest increase in reactive oxygen species (ROS) regulated SENP3 stability and localization.	Reactive Oxygen Species	130-153	SUMO specific peptidase 3	Homo sapiens	170-175
23467634-4	2013	The expression of SENP3 was higher in OSCC tissues than that in the normal mucosa adjacent to the tumor, and a modest increase in reactive oxygen species (ROS) regulated SENP3 stability and localization.	Reactive Oxygen Species	155-158	SUMO specific peptidase 3	Homo sapiens	170-175
23467634-5	2013	ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm.	Reactive Oxygen Species	0-3	SUMO specific peptidase 3	Homo sapiens	12-17
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	SUMO specific peptidase 3	Homo sapiens	86-91
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	SUMO specific peptidase 3	Homo sapiens	123-128
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	Cysteine	39-48	SUMO specific peptidase 3	Homo sapiens	86-91
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	Cysteine	39-48	SUMO specific peptidase 3	Homo sapiens	123-128
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	SUMO specific peptidase 3	Homo sapiens	120-125
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	SUMO specific peptidase 3	Homo sapiens	157-162
20924358-5	2010	Upon mild oxidative stress, SENP3 undergoes thiol modification, which recruits Hsp90.	Sulfhydryl Compounds	44-49	SUMO specific peptidase 3	Homo sapiens	28-33
20181954-3	2010	Here, we show that low doses of hydrogen peroxide (H(2)O(2)) induce an increase of the SENP3 protein, which removes SUMO2/3 from promyelocytic leukemia (PML).	Hydrogen Peroxide	51-59	SUMO specific peptidase 3	Homo sapiens	87-92
20181954-4	2010	Low dose H(2)O(2) causes SENP3 to co-localize with PML bodies and reduces the number of PML bodies in a SENP3-dependent manner.	Hydrogen Peroxide	9-17	SUMO specific peptidase 3	Homo sapiens	25-30
20181954-4	2010	Low dose H(2)O(2) causes SENP3 to co-localize with PML bodies and reduces the number of PML bodies in a SENP3-dependent manner.	Hydrogen Peroxide	9-17	SUMO specific peptidase 3	Homo sapiens	104-109
17704192-6	2008	The modifications are further elucidated by the crystal structures of Ulp1 with the catalytic cysteine oxidized to sulfenic, sulfinic, and sulfonic acids.	Cysteine	94-102	SUMO specific peptidase 3	Homo sapiens	70-74
17704192-6	2008	The modifications are further elucidated by the crystal structures of Ulp1 with the catalytic cysteine oxidized to sulfenic, sulfinic, and sulfonic acids.	sulfenic	115-123	SUMO specific peptidase 3	Homo sapiens	70-74
17704192-6	2008	The modifications are further elucidated by the crystal structures of Ulp1 with the catalytic cysteine oxidized to sulfenic, sulfinic, and sulfonic acids.	sulfinic	125-133	SUMO specific peptidase 3	Homo sapiens	70-74
17704192-6	2008	The modifications are further elucidated by the crystal structures of Ulp1 with the catalytic cysteine oxidized to sulfenic, sulfinic, and sulfonic acids.	Sulfonic Acids	139-153	SUMO specific peptidase 3	Homo sapiens	70-74
11884512-5	2002	However ulp1.d cells are less sensitive to ionising radiation and hydroxyurea (HU) than are rad31.d and hus5.62.	Hydroxyurea	66-77	SUMO specific peptidase 3	Homo sapiens	8-12
10852254-4	2000	RESULTS: Stimulation with anti-CD3 and dexamethasone induced apoptosis in 72% and 71% of SSP3.7 cells, respectively.	Dexamethasone	39-52	SUMO specific peptidase 3	Homo sapiens	89-93
10852254-6	2000	By contrast, 80% of SSP3.7 cells became apoptotic when stimulated by dexamethasone, even in the presence of BUC.	Dexamethasone	69-82	SUMO specific peptidase 3	Homo sapiens	20-24
10852254-8	2000	Although SA981 (a metabolite of BUC) inhibited apoptosis of SSP3.7 cells induced by anti-CD3, D-Pen did not.	bucillamine disulfide	9-14	SUMO specific peptidase 3	Homo sapiens	60-64