PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33727061-1	2021	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P1-S1P5.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	116-120
33727061-1	2021	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P1-S1P5.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	116-120
33727061-1	2021	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which modulates vascular integrity through its receptors, S1P1-S1P5.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	116-120
34059068-10	2021	Results confirmed BAF312@cRGD-CaP-NP could dramatically inhibit tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the S1PR1/P-STAT3/VEGFA axis.	siponimod	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	163-168
34059068-11	2021	CONCLUSIONS: Our data suggest a potent role for BAF312@cRGD-CaP-NPs in treating BRCA, especially TNBC by downregulating the S1PR1/P-STAT3/VEGFA axis.	siponimod	48-54	sphingosine-1-phosphate receptor 1	Mus musculus	124-129
33197483-3	2021	S1P is a bioactive sphingolipid mediator involved in various cellular functions via S1P receptor (S1PR) 1-5, expressed by keratinocytes.	Sphingolipids	19-31	sphingosine-1-phosphate receptor 1	Mus musculus	98-107
33926208-3	2021	Objective: Studies have invoked a crucial role of sphingosine-1-phosphate (S1P) in resolving endothelial hyperpermeability through the activation of the G-protein coupled receptor, sphingosine-1-phosphate receptor 1 (S1PR1).	sphingosine 1-phosphate	50-73	sphingosine-1-phosphate receptor 1	Mus musculus	181-215
33926208-3	2021	Objective: Studies have invoked a crucial role of sphingosine-1-phosphate (S1P) in resolving endothelial hyperpermeability through the activation of the G-protein coupled receptor, sphingosine-1-phosphate receptor 1 (S1PR1).	sphingosine 1-phosphate	50-73	sphingosine-1-phosphate receptor 1	Mus musculus	217-222
33610668-0	2021	Selective sphingosine-1-phosphate receptor 1 modulation ameliorates TBI-induced neurological deficit after CCI.	CCI	107-110	sphingosine-1-phosphate receptor 1	Mus musculus	10-44
33658712-1	2021	The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where the concentration of S1P is relatively low, into circulatory fluids, where the concentration of S1P is high1.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
33107091-3	2021	In this report, we examined if OCL-derived sphingosine-1-phosphate (S1P) contributed to the abnormal bone formation in PD, since OCL-derived S1P can act as a coupling factor to increase normal bone formation via binding S1P-receptor-3 (S1PR3) on osteoblasts (OBs).	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
33658712-1	2021	The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where the concentration of S1P is relatively low, into circulatory fluids, where the concentration of S1P is high1.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
32418220-11	2021	Importantly, in vivo intervention blocking of S1P/S1PR1 signaling markedly attenuated alcohol-induced liver inflammation, steatosis, and damage.	Alcohols	86-93	sphingosine-1-phosphate receptor 1	Mus musculus	50-55
33658712-1	2021	The lipid chemoattractant sphingosine 1-phosphate (S1P) guides cells out of tissues, where the concentration of S1P is relatively low, into circulatory fluids, where the concentration of S1P is high1.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
33460688-2	2021	FingolimodR (FTY720) is the first functional antagonist of S1P1 that has been approved for oral treatment of MS.	fingolimodr	0-11	sphingosine-1-phosphate receptor 1	Mus musculus	59-63
33460688-2	2021	FingolimodR (FTY720) is the first functional antagonist of S1P1 that has been approved for oral treatment of MS.	Fingolimod Hydrochloride	13-19	sphingosine-1-phosphate receptor 1	Mus musculus	59-63
33460688-6	2021	Both novel compounds exerted H3R affinities, and in addition, ST-1505 was characterised as a dual S1P1+3 agonist, whereas ST-1478 was a dual S1P1+5 agonist.	st-1505	62-69	sphingosine-1-phosphate receptor 1	Mus musculus	98-102
33460688-6	2021	Both novel compounds exerted H3R affinities, and in addition, ST-1505 was characterised as a dual S1P1+3 agonist, whereas ST-1478 was a dual S1P1+5 agonist.	st-1478	122-129	sphingosine-1-phosphate receptor 1	Mus musculus	141-145
33474512-8	2021	Results from OCTA revealed that collateral vessels are increased in response to administration of a S1PR1 agonist in a mouse RVO model.	CDTA	13-17	sphingosine-1-phosphate receptor 1	Mus musculus	100-105
33534341-0	2021	Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice.	doca-salt	83-92	sphingosine-1-phosphate receptor 1	Mus musculus	37-71
33534341-3	2021	METHODS: CD-specific S1PR1 knockout mice were generated by crossing aquaporin-2-Cre mice with S1PR1-floxed mice.	Cadmium	9-11	sphingosine-1-phosphate receptor 1	Mus musculus	21-26
33534341-3	2021	METHODS: CD-specific S1PR1 knockout mice were generated by crossing aquaporin-2-Cre mice with S1PR1-floxed mice.	Cadmium	9-11	sphingosine-1-phosphate receptor 1	Mus musculus	94-99
33534341-5	2021	RESULTS: Protein levels of renal medullary S1PR1 were increased by 100% after high-salt intake, whereas DOCA treatment with high-salt intake blocked the increase of S1PR1 levels.	Salts	83-87	sphingosine-1-phosphate receptor 1	Mus musculus	43-48
33534341-5	2021	RESULTS: Protein levels of renal medullary S1PR1 were increased by 100% after high-salt intake, whereas DOCA treatment with high-salt intake blocked the increase of S1PR1 levels.	Desoxycorticosterone Acetate	104-108	sphingosine-1-phosphate receptor 1	Mus musculus	165-170
33534341-5	2021	RESULTS: Protein levels of renal medullary S1PR1 were increased by 100% after high-salt intake, whereas DOCA treatment with high-salt intake blocked the increase of S1PR1 levels.	Salts	129-133	sphingosine-1-phosphate receptor 1	Mus musculus	165-170
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	Sodium	45-51	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	Sodium	72-78	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	doca-salt	106-115	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	Salts	111-115	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	Sodium	72-78	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33534341-10	2021	CONCLUSION: The deletion of CD-S1PR1 reduced sodium excretion, promoted sodium retention, and accelerated DOCA-salt-induced salt-sensitive hypertension, suggesting that the CD-S1PR1 signaling is an important antihypertensive pathway by promoting sodium excretion and that impairment of renal medullary S1PR1 may represent a novel mechanism for salt-sensitive hypertension.	Salts	124-128	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
33400020-0	2021	SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway.	SEW2871	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	88-122
33400020-4	2021	Here, we showed that SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1(S1PR1), alleviated ANIT-induced TJs damage in 3D-cultured mice primary hepatocytes.	SEW2871	21-28	sphingosine-1-phosphate receptor 1	Mus musculus	53-87
33400020-4	2021	Here, we showed that SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1(S1PR1), alleviated ANIT-induced TJs damage in 3D-cultured mice primary hepatocytes.	SEW2871	21-28	sphingosine-1-phosphate receptor 1	Mus musculus	88-93
33400020-4	2021	Here, we showed that SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1(S1PR1), alleviated ANIT-induced TJs damage in 3D-cultured mice primary hepatocytes.	1-Naphthylisothiocyanate	107-111	sphingosine-1-phosphate receptor 1	Mus musculus	53-87
33400020-4	2021	Here, we showed that SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1(S1PR1), alleviated ANIT-induced TJs damage in 3D-cultured mice primary hepatocytes.	1-Naphthylisothiocyanate	107-111	sphingosine-1-phosphate receptor 1	Mus musculus	88-93
33400020-8	2021	Further protection mechanism research demonstrated that SEW2871 not only regained hepatocyte TJs by the upregulated S1PR1 via AMPK signaling pathway, but also recovered hepatobiliary barrier function deficiency, which was verified by the restored BA homeostasis by using of high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS).	SEW2871	56-63	sphingosine-1-phosphate receptor 1	Mus musculus	116-121
33400020-9	2021	These results revealed that the increased expression of S1PR1 induced by SEW2871 could ameliorate ANIT-induced cholestatic liver injury through improving liver barrier function via AMPK signaling and subsequently reversed the disrupted BA homeostasis.	SEW2871	73-80	sphingosine-1-phosphate receptor 1	Mus musculus	56-61
33400020-9	2021	These results revealed that the increased expression of S1PR1 induced by SEW2871 could ameliorate ANIT-induced cholestatic liver injury through improving liver barrier function via AMPK signaling and subsequently reversed the disrupted BA homeostasis.	Bile Acids and Salts	236-238	sphingosine-1-phosphate receptor 1	Mus musculus	56-61
33301355-2	2021	Sphingosine 1-phosphate (S1P) signaling coordinates vascular functions in other organs, and S1P receptor-1 (S1P1) modulators including fingolimod show promise for the treatment of ischemic and hemorrhagic stroke.	Fingolimod Hydrochloride	135-145	sphingosine-1-phosphate receptor 1	Mus musculus	92-106
33301355-2	2021	Sphingosine 1-phosphate (S1P) signaling coordinates vascular functions in other organs, and S1P receptor-1 (S1P1) modulators including fingolimod show promise for the treatment of ischemic and hemorrhagic stroke.	Fingolimod Hydrochloride	135-145	sphingosine-1-phosphate receptor 1	Mus musculus	108-112
33271273-6	2021	The S1PR1-antagonist W123 and pertussis-toxin prevented the S1P-induced currents, showing the involvement of the Gi-protein-coupled S1P receptor 1 (S1PR1).	W123    Exclusive	21-25	sphingosine-1-phosphate receptor 1	Mus musculus	4-9
33271273-6	2021	The S1PR1-antagonist W123 and pertussis-toxin prevented the S1P-induced currents, showing the involvement of the Gi-protein-coupled S1P receptor 1 (S1PR1).	W123    Exclusive	21-25	sphingosine-1-phosphate receptor 1	Mus musculus	132-146
33271273-6	2021	The S1PR1-antagonist W123 and pertussis-toxin prevented the S1P-induced currents, showing the involvement of the Gi-protein-coupled S1P receptor 1 (S1PR1).	W123    Exclusive	21-25	sphingosine-1-phosphate receptor 1	Mus musculus	148-153
33257316-1	2021	ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5.	ceralifimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	111-132
33257316-1	2021	ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5.	sphingosine 1-phosphate	32-55	sphingosine-1-phosphate receptor 1	Mus musculus	111-132
33257316-1	2021	ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator that exhibits selectivity for S1P receptors 1 and 5.	sphingosine 1-phosphate	57-60	sphingosine-1-phosphate receptor 1	Mus musculus	111-132
33257316-11	2021	Significance Statement ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator selective for S1P receptors 1 and 5.	ceralifimod	23-31	sphingosine-1-phosphate receptor 1	Mus musculus	118-139
33257316-11	2021	Significance Statement ONO-4641 is a second-generation sphingosine 1-phosphate (S1P) receptor modulator selective for S1P receptors 1 and 5.	sphingosine 1-phosphate	55-78	sphingosine-1-phosphate receptor 1	Mus musculus	118-139
33574820-7	2020	The transfection with miR-223-3p mimic significantly suppressed a luciferase activity in HUVEC treated with a Lentivirus vector containing 3" UTR of S1pr1.	mir-223-3p	22-32	sphingosine-1-phosphate receptor 1	Mus musculus	149-154
32424937-0	2020	Coinhibition of S1PR1 and GP130 by siRNA-loaded alginate-conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells.	Alginates	48-56	sphingosine-1-phosphate receptor 1	Mus musculus	16-21
32424937-0	2020	Coinhibition of S1PR1 and GP130 by siRNA-loaded alginate-conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells.	trimethyl chitosan	68-86	sphingosine-1-phosphate receptor 1	Mus musculus	16-21
32424937-4	2020	Therefore, we silenced STAT3 upstream molecules including the S1PR1 and GP130 molecules in cancer cells using small interfering RNA (siRNA)-loaded alginate-conjugated trimethyl chitosan (ATMC) nanoparticles (NPs).	atmc	187-191	sphingosine-1-phosphate receptor 1	Mus musculus	62-67
33092620-2	2020	We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalgesia and analgesic tolerance.	sphingosine 1-phosphate	31-54	sphingosine-1-phosphate receptor 1	Mus musculus	73-78
32810834-8	2020	TP also efficiently decreased the S1P levels and SPHK1/S1PR1/S1PR2 expression and significantly inhibited activation of the S1P-mediated phosphorylation of ERK protein in macrophages.	triptolide	0-2	sphingosine-1-phosphate receptor 1	Mus musculus	55-60
33092620-2	2020	We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalgesia and analgesic tolerance.	Morphine	117-125	sphingosine-1-phosphate receptor 1	Mus musculus	73-78
33092620-7	2020	Mechanistically, at the level of the spinal cord, naloxone-precipitated withdrawal was associated with increased glial activity and formation of the potent inflammatory/neuroexcitatory cytokine interleukin-1beta (IL-1beta); these events were attenuated by S1PR1 antagonists.	Naloxone	50-58	sphingosine-1-phosphate receptor 1	Mus musculus	256-261
33092620-9	2020	Our data identify S1PR1 antagonists as potential therapeutics to mitigate opioid-induced dependence and support repurposing the S1PR1 functional antagonist FTY720, which is FDA-approved for multiple sclerosis, as an opioid adjunct.	Fingolimod Hydrochloride	156-162	sphingosine-1-phosphate receptor 1	Mus musculus	18-23
33092620-9	2020	Our data identify S1PR1 antagonists as potential therapeutics to mitigate opioid-induced dependence and support repurposing the S1PR1 functional antagonist FTY720, which is FDA-approved for multiple sclerosis, as an opioid adjunct.	Fingolimod Hydrochloride	156-162	sphingosine-1-phosphate receptor 1	Mus musculus	128-133
32899717-0	2020	Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis.	Morpholinos	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	58-62
33050288-2	2020	Among them, the lipid mediator sphingosine-1-phosphate (S1P) is involved in maintaining epithelial and endothelial barrier integrity and in governing the migration of immune cells through the interaction with S1P1-5 receptors.	sphingosine 1-phosphate	31-54	sphingosine-1-phosphate receptor 1	Mus musculus	209-213
33050288-2	2020	Among them, the lipid mediator sphingosine-1-phosphate (S1P) is involved in maintaining epithelial and endothelial barrier integrity and in governing the migration of immune cells through the interaction with S1P1-5 receptors.	sphingosine 1-phosphate	56-59	sphingosine-1-phosphate receptor 1	Mus musculus	209-213
32579994-0	2020	Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.	SEW2871	52-59	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
32579994-0	2020	Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.	1-Naphthylisothiocyanate	72-76	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
32579994-0	2020	Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.	Bile Acids and Salts	102-111	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
32579994-2	2020	Here, we showed that the expression of sphingosine-1-phosphate receptor 1 (S1PR1) was down-regulated by alpha-naphthylisothiocyanate (ANIT) in vivo and in vitro.	1-Naphthylisothiocyanate	104-132	sphingosine-1-phosphate receptor 1	Mus musculus	39-73
32579994-2	2020	Here, we showed that the expression of sphingosine-1-phosphate receptor 1 (S1PR1) was down-regulated by alpha-naphthylisothiocyanate (ANIT) in vivo and in vitro.	1-Naphthylisothiocyanate	104-132	sphingosine-1-phosphate receptor 1	Mus musculus	75-80
32579994-2	2020	Here, we showed that the expression of sphingosine-1-phosphate receptor 1 (S1PR1) was down-regulated by alpha-naphthylisothiocyanate (ANIT) in vivo and in vitro.	1-Naphthylisothiocyanate	134-138	sphingosine-1-phosphate receptor 1	Mus musculus	39-73
32579994-2	2020	Here, we showed that the expression of sphingosine-1-phosphate receptor 1 (S1PR1) was down-regulated by alpha-naphthylisothiocyanate (ANIT) in vivo and in vitro.	1-Naphthylisothiocyanate	134-138	sphingosine-1-phosphate receptor 1	Mus musculus	75-80
32579994-3	2020	The up-regulated S1PR1 induced by SEW2871 (a specific agonist of S1PR1) could improve ANIT-induced deficiency of hepatocyte tight junctions (TJs), cholestatic liver injury and the disrupted BA homeostasis in mice.	SEW2871	34-41	sphingosine-1-phosphate receptor 1	Mus musculus	17-22
32579994-3	2020	The up-regulated S1PR1 induced by SEW2871 (a specific agonist of S1PR1) could improve ANIT-induced deficiency of hepatocyte tight junctions (TJs), cholestatic liver injury and the disrupted BA homeostasis in mice.	SEW2871	34-41	sphingosine-1-phosphate receptor 1	Mus musculus	65-70
32579994-3	2020	The up-regulated S1PR1 induced by SEW2871 (a specific agonist of S1PR1) could improve ANIT-induced deficiency of hepatocyte tight junctions (TJs), cholestatic liver injury and the disrupted BA homeostasis in mice.	Bile Acids and Salts	190-192	sphingosine-1-phosphate receptor 1	Mus musculus	17-22
32579994-3	2020	The up-regulated S1PR1 induced by SEW2871 (a specific agonist of S1PR1) could improve ANIT-induced deficiency of hepatocyte tight junctions (TJs), cholestatic liver injury and the disrupted BA homeostasis in mice.	Bile Acids and Salts	190-192	sphingosine-1-phosphate receptor 1	Mus musculus	65-70
32579994-8	2020	In conclusion, these results demonstrated that S1PR1 selective agonists might be the novel and potential effective agents for the treatment of intrahepatic cholestasis by recovering dysregulated BA homeostasis.	Bile Acids and Salts	195-197	sphingosine-1-phosphate receptor 1	Mus musculus	47-52
33101013-0	2020	Coix Seed Oil Exerts an Anti-Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis.	coix seed oil	0-13	sphingosine-1-phosphate receptor 1	Mus musculus	88-93
33101013-8	2020	The expression of sphingosine 1 phosphate receptor 1 (S1PR1), the critical effector of SM, was downregulated upon CSO treatment.	Samarium	87-89	sphingosine-1-phosphate receptor 1	Mus musculus	18-52
33101013-8	2020	The expression of sphingosine 1 phosphate receptor 1 (S1PR1), the critical effector of SM, was downregulated upon CSO treatment.	Samarium	87-89	sphingosine-1-phosphate receptor 1	Mus musculus	54-59
33101013-8	2020	The expression of sphingosine 1 phosphate receptor 1 (S1PR1), the critical effector of SM, was downregulated upon CSO treatment.	CSO	114-117	sphingosine-1-phosphate receptor 1	Mus musculus	18-52
33101013-8	2020	The expression of sphingosine 1 phosphate receptor 1 (S1PR1), the critical effector of SM, was downregulated upon CSO treatment.	CSO	114-117	sphingosine-1-phosphate receptor 1	Mus musculus	54-59
33101013-11	2020	These results revealed that CSO exerted an anti-TNBC effect via the miR-205/S1PR1 axis to regulate sphingomyelin metabolism, and the downstream STAT3/MAPK/AKT signal pathways were partly involved.	CSO	28-31	sphingosine-1-phosphate receptor 1	Mus musculus	76-81
32899717-0	2020	Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis.	Fingolimod Hydrochloride	24-34	sphingosine-1-phosphate receptor 1	Mus musculus	58-62
32899717-3	2020	A new therapeutic paradigm for the treatment of MS was introduced in 2010 through the sphingosine 1-phosphate (S1P) analogue fingolimod (FTY720, Gilenya ), which acts as a functional S1P1 antagonist on T lymphocytes to deplete these cells from the blood.	sphingosine 1-phosphate	86-109	sphingosine-1-phosphate receptor 1	Mus musculus	183-187
32899717-3	2020	A new therapeutic paradigm for the treatment of MS was introduced in 2010 through the sphingosine 1-phosphate (S1P) analogue fingolimod (FTY720, Gilenya ), which acts as a functional S1P1 antagonist on T lymphocytes to deplete these cells from the blood.	Fingolimod Hydrochloride	125-135	sphingosine-1-phosphate receptor 1	Mus musculus	183-187
32899717-3	2020	A new therapeutic paradigm for the treatment of MS was introduced in 2010 through the sphingosine 1-phosphate (S1P) analogue fingolimod (FTY720, Gilenya ), which acts as a functional S1P1 antagonist on T lymphocytes to deplete these cells from the blood.	Fingolimod Hydrochloride	137-143	sphingosine-1-phosphate receptor 1	Mus musculus	183-187
32484801-2	2020	It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1,3,4, and 5.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	61-80
32301840-9	2020	Our data support investigating S1PR1 antagonists as a clinical approach to mitigate opioid-induced adverse effects and repurposing the functional S1PR1 antagonist FTY720, which is FDA-approved for multiple sclerosis, as an opioid adjunct.	Fingolimod Hydrochloride	163-169	sphingosine-1-phosphate receptor 1	Mus musculus	146-151
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	151-155
32402923-7	2020	Administration of FTY720, an inhibitory agonist of sphingosine 1-phosphate receptor 1 that stabilizes TJ permeability, increased the myeloid cell proportion in milk.	Fingolimod Hydrochloride	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	51-85
32301840-6	2020	In mouse neuropathic pain models, S1PR1 antagonists blocked the development of tolerance to the anti-allodynic effects of morphine without altering morphine pharmacokinetics and prevented prolonged morphine-induced neuropathic pain.	Morphine	122-130	sphingosine-1-phosphate receptor 1	Mus musculus	34-39
32301840-7	2020	Targeting S1PR1 reduced morphine-induced neuroinflammatory events in the dorsal horn of the spinal cord: increased glial marker expression, mitogen-activated protein kinase p38 and nuclear factor kappaB activation and increased inflammatory cytokine expression, such as interleukin-1beta, a cytokine central in the modulation of opioid-induced neural plasticity.	Morphine	24-32	sphingosine-1-phosphate receptor 1	Mus musculus	10-15
32301840-8	2020	Our results identify S1PR1 as a critical path for S1P signaling in response to sustained morphine and reveal downstream neuroinflammatory pathways impacted by S1PR1 activation.	Morphine	89-97	sphingosine-1-phosphate receptor 1	Mus musculus	21-26
31455837-1	2020	Sphingosine-1-phosphate (S1P), a sphingolipid with second messenger properties, is a main regulator of various cellular processes including lymphocyte cell trafficking, angiogenesis, cell proliferation, and survival.	Sphingolipids	33-45	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
32722120-1	2020	Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1-5 receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	106-112
32722120-1	2020	Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1-5 receptors.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	106-112
32278723-3	2020	S1PR1, 3, and 5 were transiently induced in the cells, which were morphologically similar to neurons in the peri-infarct lesion with a peak seen at 1 day after tMCAO (p < 0.01 vs. sham control).	tmcao	160-165	sphingosine-1-phosphate receptor 1	Mus musculus	0-5
32255764-8	2020	As this KLF2/S1PR1 axis represents the essential cell-intrinsic regulator of T cell lymph node egress, we conclude that the druggable Notch signaling pathway licenses the Th2 response in allergic airway inflammation via promoting lymph node egress.	th2	171-174	sphingosine-1-phosphate receptor 1	Mus musculus	13-18
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	83-89
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	151-155
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	83-89
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	Fingolimod Hydrochloride	165-171	sphingosine-1-phosphate receptor 1	Mus musculus	83-89
32670281-2	2020	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in mice treated with S1PR agonist, FTY720 (FTY).	Fingolimod Hydrochloride	165-171	sphingosine-1-phosphate receptor 1	Mus musculus	151-155
32455907-6	2020	Electrophysiological studies with selective S1P1 (AUY954) and S1P5 (A971432) agonists suggested that S1P1 modulation is the main driver of the anti-excitotoxic activity mediated by ozanimod.	ozanimod	181-189	sphingosine-1-phosphate receptor 1	Mus musculus	101-105
32544390-3	2020	This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P receptor 1 (S1PR1) in the vascular endothelial cells of lung and kidney.	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	70-84
32544390-3	2020	This leads to reduced sphingosine-1-phosphate (S1P) signaling via the S1P receptor 1 (S1PR1) in the vascular endothelial cells of lung and kidney.	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	86-91
32544390-4	2020	Suboptimal S1PR1 angiocrine signaling causes reduced resistance to injury-induced vascular leak and leads to organ fibrosis.	angiocrine	17-27	sphingosine-1-phosphate receptor 1	Mus musculus	11-16
32488676-0	2020	Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages.	siponimod	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	74-78
32488676-0	2020	Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages.	siponimod	11-18	sphingosine-1-phosphate receptor 1	Mus musculus	74-78
32488676-6	2020	We found that siponimod downregulates the expression of RhoA protein and decreases the cell surface expression of S1P1 and CX3CR1 receptors.	siponimod	14-23	sphingosine-1-phosphate receptor 1	Mus musculus	114-118
32514255-10	2020	Conclusions: Taken together, our data suggest that SPC and S1P1 antagonist KRO-105714 has the potential to alleviate atopic dermatitis.	UNII-66G2URF5HG	75-85	sphingosine-1-phosphate receptor 1	Mus musculus	59-63
32393187-1	2020	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2).	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
32202615-2	2020	The aim of this study was to assess the sphingolipid, sphingosine-1-phosphate (S1P), as a potential in vitro activation agent in murine and human ovarian tissues and isolated follicles.	Sphingolipids	40-52	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
32202615-6	2020	This increase was shown to be specific for the Hippo signaling pathway and for the S1P2 receptor, as co-treatment with Hippo-inhibitor, verteporfin, and S1PR2 antagonist, JTE-013, reduced the S1P-induced Ccn2 gene expression in murine ovaries.	Verteporfin	136-147	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
32393187-1	2020	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2).	Sphingolipids	71-84	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
32393187-4	2020	This study tested the hypothesis that SphK1/S1P pathway mediates the kidney damage in DOCA-salt hypertensive mice.	doca-salt	86-95	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
32393187-19	2020	CONCLUSIONS: SphK1/S1P signaling pathway mediates kidney damage in DOCA-salt hypertensive mice independent of blood pressure and immune modulation.	doca-salt	67-76	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Sphingosine	20-31	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Ceramides	89-97	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
31916656-2	2020	S1P is generated by sphingosine kinases (SPHK1 and SPHK2) through the phosphorylation of ceramide-derived sphingosine.	Sphingosine	106-117	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
31916656-9	2020	Adding exogenous S1P to the medium had no impact, but the cell cycle arrest is partially alleviated by the expression of a ceramide synthase (CERS2), which converts excess sphingosine to ceramide.	Ceramides	123-131	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
31916656-12	2020	We used a genetic approach to eliminate S1P from murine ESCs by deleting both sphingosine kinase orthologs.	Sphingosine	78-89	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
32290092-6	2020	Constitutive barrier stability of HUVEC, but not EA.hy926, was significantly compromised by the S1PR1 antagonist W146 and by the anti-S1P antibody Sphingomab.	W146	113-117	sphingosine-1-phosphate receptor 1	Mus musculus	96-101
31742704-1	2020	Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through a family of five G-protein coupled receptors, S1PR1-S1PR5, to regulate cell physiology.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31742704-2	2020	The multiple sclerosis drug Fingolimod (FTY720) is a potent S1P receptor agonist that causes peripheral lymphopenia.	fingolimod	28-38	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
31742704-2	2020	The multiple sclerosis drug Fingolimod (FTY720) is a potent S1P receptor agonist that causes peripheral lymphopenia.	fingolimod	40-46	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
31742704-5	2020	S1P induced brain-derived neurotrophic factor (BDNF), leukemia inhibitory factor (LIF), platelet-derived growth factor B (PDGFB) and heparin-binding EGF-like growth factor (HBEGF) gene expression in primary human and murine astrocytes, but not in neurons, and to a much greater extent than FTY720.	fingolimod	290-296	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
31916095-2	2020	Here, we studied DNA damage and repair as a function of male aging and assessed whether sphingosine-1-phosphate (S1P), a ceramide-induced death inhibitor, can prevent sperm aging by enhancing DNA double-strand breaks (DSB) repair.	sphingosine 1-phosphate	88-111	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
31802363-1	2020	Sphingosine 1-phosphate (S1P) is a major bioactive lipid mediator in the vascular and immune system.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	147-150
31802363-3	2020	In the in vitro BBB models, oxygen-glucose deprivation and reoxygenation (OGD/R) enhanced the expression of an S1P synthesizing enzyme (Sphk1) and S1P transporters (Abca1, Spns2), increasing S1P in culture media.	Oxygen	28-42	sphingosine-1-phosphate receptor 1	Mus musculus	147-150
31802363-6	2020	Furthermore, MCAO/R caused activation of STAT3, a downstream mediator of S1P signaling, which was suppressed by postoperative probucol administration.	Probucol	126-134	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
31802363-8	2020	These results suggest that inhibition of S1P signaling is a strategy to treat BBB impairment after cerebral ischemia and highlight the potential alternative use of probucol, a classical anti-hyperlipidemic drug, for emergency treatment of stroke.	Probucol	164-172	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
32192225-0	2020	Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.	reactive	119-127	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
32192225-0	2020	Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.	oxygen species	128-142	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
32192225-1	2020	The sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice.	sphingosine 1-phosphate	33-56	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
32192225-1	2020	The sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice.	Bleomycin	168-177	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
32194396-11	2020	The S1P1 antagonist VPC23019 blocked the stimulatory effects of nmFGF1, whereas the S1P1 agonist FTY720 exerted effects comparable with those of nmFGF1.	VPC23019	20-28	sphingosine-1-phosphate receptor 1	Mus musculus	4-8
32194396-12	2020	Furthermore, PD173074 reversed the effect of nmFGF1 on upregulating S1P1 signaling.	PD 173074	13-21	sphingosine-1-phosphate receptor 1	Mus musculus	68-72
31944406-1	2020	Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31944406-2	2020	Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1.	Carbon	79-88	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
31916095-2	2020	Here, we studied DNA damage and repair as a function of male aging and assessed whether sphingosine-1-phosphate (S1P), a ceramide-induced death inhibitor, can prevent sperm aging by enhancing DNA double-strand breaks (DSB) repair.	Ceramides	121-129	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
31904729-10	2020	Baicalein also significantly decreased the levels of inflammatory mediators in the serum (P &lt; 0.01) and colon, and significantly inhibited expression of NOD2 SPHK1, S1PR1, and p-STAT3 in the colon (P &lt; 0.05).	baicalein	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	168-173
32060392-8	2020	In primary cortical cells S1P and LPA mobilize Ca2+ from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425.	sphingosine 1-phosphate	26-29	sphingosine-1-phosphate receptor 1	Mus musculus	106-126
32060392-8	2020	In primary cortical cells S1P and LPA mobilize Ca2+ from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425.	lysophosphatidic acid	34-37	sphingosine-1-phosphate receptor 1	Mus musculus	106-126
32060392-8	2020	In primary cortical cells S1P and LPA mobilize Ca2+ from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425.	Calcium	47-51	sphingosine-1-phosphate receptor 1	Mus musculus	106-126
32060392-8	2020	In primary cortical cells S1P and LPA mobilize Ca2+ from internal stores via a mechanism sensitive to the S1P and LPA receptor antagonists Ex26, H2L5186303, or Ki16425.	Hydrogen	145-155	sphingosine-1-phosphate receptor 1	Mus musculus	106-126
31739156-4	2020	Fingolimod was functionally active during remyelination by downregulating S1PR1 brain levels, and fingolimod-treated mice had more oligodendrocytes in the secondary motor cortex after three weeks of remyelination.	fingolimod	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	74-79
31988136-9	2020	Furthermore, antitumor activity of a chemotherapeutic agent (doxorubicin) and immune checkpoint inhibitor blocker (anti-PD-1 antibody) were more effective in S1pr1 ECTG than in the wild-type counterparts.	Doxorubicin	61-72	sphingosine-1-phosphate receptor 1	Mus musculus	158-163
31815756-5	2020	The ApoM is a chaperone for the bioactive sphingolipid, sphingosine-1-phosphate (S1P), which has a specific role in inflammation.	Sphingolipids	42-54	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
30835815-12	2020	L-serine or L-cysteine incubation increased NO and S1P levels in mouse aorta.	Serine	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
30835815-12	2020	L-serine or L-cysteine incubation increased NO and S1P levels in mouse aorta.	Cysteine	12-22	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
30835815-14	2020	The L-serine effect involves both NO and S1P.	Serine	4-12	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
31815756-5	2020	The ApoM is a chaperone for the bioactive sphingolipid, sphingosine-1-phosphate (S1P), which has a specific role in inflammation.	sphingosine 1-phosphate	56-79	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
31490328-9	2020	Morphine and duloxetine, both clinical analgesics, reversed BINP in female mice, demonstrating that the lack of response is specific to S1PR1 and A3AR agents.	Morphine	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	136-141
31708456-3	2020	The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except S1PR2, and also acts as a functional antagonist of S1PR1.	Fingolimod Hydrochloride	13-19	sphingosine-1-phosphate receptor 1	Mus musculus	199-204
31708456-3	2020	The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except S1PR2, and also acts as a functional antagonist of S1PR1.	Fingolimod Hydrochloride	21-31	sphingosine-1-phosphate receptor 1	Mus musculus	199-204
31708456-6	2020	We discuss recent studies demonstrating that neuropathic pain induced by the chemotherapeutic bortezomib is also greatly reduced by administration of clinically relevant doses of FTY720, likely by targeting S1PR1 on astrocytes.	Bortezomib	94-104	sphingosine-1-phosphate receptor 1	Mus musculus	207-212
32038629-0	2019	Sphingosine-1-Phosphate (S-1P) Promotes Differentiation of Naive Macrophages and Enhances Protective Immunity Against Mycobacterium tuberculosis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-29
32038629-1	2019	Sphingosine-1-phosphate (S-1P) is a key sphingolipid involved in the pathobiology of various respiratory diseases.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-29
32038629-1	2019	Sphingosine-1-phosphate (S-1P) is a key sphingolipid involved in the pathobiology of various respiratory diseases.	Sphingolipids	40-52	sphingosine-1-phosphate receptor 1	Mus musculus	25-29
32038629-6	2019	Our data suggest that enhancing S-1P levels by sphingolipid mimetic compounds/drugs can be used as an immunoadjuvant for boosting immunity against pathogenic mycobacteria.	Sphingolipids	47-59	sphingosine-1-phosphate receptor 1	Mus musculus	32-36
31490328-9	2020	Morphine and duloxetine, both clinical analgesics, reversed BINP in female mice, demonstrating that the lack of response is specific to S1PR1 and A3AR agents.	Duloxetine Hydrochloride	13-23	sphingosine-1-phosphate receptor 1	Mus musculus	136-141
31842752-3	2019	Sphingosine-1- phosphate (S1P), a bioactive lipid, is known to play a key role in facilitating infection.	sphingosine 1-phosphate	0-24	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
31861195-2	2019	Pilot experiments showed that the vasoconstrictor effect of S1P was enhanced markedly in the presence of phenylephrine (PE).	Phenylephrine	105-118	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
31861195-2	2019	Pilot experiments showed that the vasoconstrictor effect of S1P was enhanced markedly in the presence of phenylephrine (PE).	Phenylephrine	120-122	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
31861195-4	2019	In murine aortas, a 20-minute exposure to S1P but not to its vehicle increased the Emax and decreased the EC50 of PE-induced contractions indicating a hyperreactivity to alpha1-adrenergic stimulation.	Phenylephrine	114-116	sphingosine-1-phosphate receptor 1	Mus musculus	42-45
31861195-6	2019	In addition, smooth muscle specific conditional deletion of G12/13 proteins or pharmacological inhibition of the Rho-associated protein kinase (ROCK) by Y-27632 or fasudil abolished the effect of S1P on alpha1-adrenergic vasoconstriction.	Y 27632	153-160	sphingosine-1-phosphate receptor 1	Mus musculus	196-199
31861195-6	2019	In addition, smooth muscle specific conditional deletion of G12/13 proteins or pharmacological inhibition of the Rho-associated protein kinase (ROCK) by Y-27632 or fasudil abolished the effect of S1P on alpha1-adrenergic vasoconstriction.	fasudil	164-171	sphingosine-1-phosphate receptor 1	Mus musculus	196-199
31861195-7	2019	Unexpectedly, PE-induced contractions remained enhanced markedly as late as three hours after S1P-exposure in wild-type (WT) and S1P3 KO but not in S1P2 KO vessels.	Phenylephrine	14-16	sphingosine-1-phosphate receptor 1	Mus musculus	94-97
31842752-4	2019	Sphingosine kinases (SPHK) 1&2 phosphorylate sphingosine to generate S1P in mammalian cells.	Sphingosine	45-56	sphingosine-1-phosphate receptor 1	Mus musculus	69-72
31097785-2	2019	We show that sphingosine kinase-1 (SPHK1), which generates the potent bioactive sphingolipid sphingosine-1-phosphate (S1P), is over-expressed in DLBCL.	sphingolipid sphingosine-1-phosphate	80-116	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
31202617-2	2019	We previously reported that C57BL/6J mice harboring phosphorylation defective S1P receptor 1 (S1P1) (with mutated serines in the carboxyl terminus, leading to impaired receptor internalization) [S1P1(S5A)] developed severe, TH17-dominant experimental autoimmune encephalomyelitis.	Serine	114-121	sphingosine-1-phosphate receptor 1	Mus musculus	78-92
31202617-2	2019	We previously reported that C57BL/6J mice harboring phosphorylation defective S1P receptor 1 (S1P1) (with mutated serines in the carboxyl terminus, leading to impaired receptor internalization) [S1P1(S5A)] developed severe, TH17-dominant experimental autoimmune encephalomyelitis.	Serine	114-121	sphingosine-1-phosphate receptor 1	Mus musculus	94-98
31597715-7	2019	Lymphocyte sequestration with sphingosine-1-phosphate receptor 1 antagonist FTY720 specifically inhibited anti-MHC class II antibody production and abrogated macrophage infiltration into glomeruli.	Fingolimod Hydrochloride	76-82	sphingosine-1-phosphate receptor 1	Mus musculus	30-64
31415870-1	2019	Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator, promoting angiogenesis and inflammation via interactions with its receptors (S1P1-5), but the receptors and signaling pathways responsible for the progression of choroidal neovascularization (CNV) remain unknown.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	139-143
31415870-1	2019	Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator, promoting angiogenesis and inflammation via interactions with its receptors (S1P1-5), but the receptors and signaling pathways responsible for the progression of choroidal neovascularization (CNV) remain unknown.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	139-143
31462513-10	2019	We suggest that multiple S1P chaperones evolved to support complex and essential extracellular signaling functions of this lysolipid mediator in a redundant manner.	lysolipid	123-132	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31763978-2	2019	We here examined how the apolipoprotein M (apoM)-bound sphingosine 1-phosphate (S1P) signaling pathway affects the BBB in different categories of cerebral microvessels using ApoM deficient mice (Apom-/-).	sphingosine 1-phosphate	55-78	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
31763978-6	2019	The S1P receptor 1 agonist SEW2871 rapidly normalized paracellular BBB permeability in Apom-/- mice, and inhibited transcytosis in penetrating arterioles, but not in pial arterioles.	SEW2871	27-34	sphingosine-1-phosphate receptor 1	Mus musculus	4-18
29572542-1	2019	Aryl hydrocarbon receptor (AhR), a cellular chemical sensor, controls cellular homeostasis, and sphingosine-1-phosphate (S1P), a bioactive intermediate of sphingolipid metabolism, is believed to have a role in immunity and inflammation, but their potential crosstalk is currently unknown.	sphingosine 1-phosphate	96-119	sphingosine-1-phosphate receptor 1	Mus musculus	121-124
29572542-1	2019	Aryl hydrocarbon receptor (AhR), a cellular chemical sensor, controls cellular homeostasis, and sphingosine-1-phosphate (S1P), a bioactive intermediate of sphingolipid metabolism, is believed to have a role in immunity and inflammation, but their potential crosstalk is currently unknown.	Sphingolipids	155-167	sphingosine-1-phosphate receptor 1	Mus musculus	121-124
29572542-3	2019	We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge.	Polycyclic Aromatic Hydrocarbons	55-86	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
29572542-3	2019	We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge.	Polycyclic Aromatic Hydrocarbons	88-91	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
30802544-4	2019	The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production.	Fingolimod Hydrochloride	32-38	sphingosine-1-phosphate receptor 1	Mus musculus	15-20
30997640-1	2019	Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31534971-2	2019	We hypothesized that dietary fatty acid saturation affects vasoconstriction to sphingosine-1-phosphate (S1P) through caveolar regulation of rho kinase.	Fatty Acids	29-39	sphingosine-1-phosphate receptor 1	Mus musculus	104-107
31534971-11	2019	The data suggest that dietary fatty acids modify vascular responses to S1P by a caveolar-dependent mechanism which is enhanced by dietary n-3 polyunsaturated fats.	Fatty Acids	30-41	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
31534971-11	2019	The data suggest that dietary fatty acids modify vascular responses to S1P by a caveolar-dependent mechanism which is enhanced by dietary n-3 polyunsaturated fats.	n-3 polyunsaturated fats	138-162	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
31426457-1	2019	Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.	Sphingolipids	37-49	sphingosine-1-phosphate receptor 1	Mus musculus	149-163
31426457-1	2019	Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.	Sphingolipids	37-49	sphingosine-1-phosphate receptor 1	Mus musculus	165-170
31426457-1	2019	Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.	sphingosine 1-phosphate	67-90	sphingosine-1-phosphate receptor 1	Mus musculus	149-163
31426457-1	2019	Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.	sphingosine 1-phosphate	67-90	sphingosine-1-phosphate receptor 1	Mus musculus	165-170
31426457-10	2019	Feeding stimulates mobilization of endogenous S1PR1 agonists S1P and SA1P in mouse hypothalamus, via a mechanism that involves transcriptional up-regulation of de novo sphingolipid biosynthesis.	Sphingolipids	168-180	sphingosine-1-phosphate receptor 1	Mus musculus	46-51
31412253-1	2019	Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via S1P receptor 1 (S1PR1) signaling, and it controls the differentiation of regulatory T cells (Tregs) and T helper-17 cells.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	152-166
31412253-1	2019	Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via S1P receptor 1 (S1PR1) signaling, and it controls the differentiation of regulatory T cells (Tregs) and T helper-17 cells.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	168-173
31036923-3	2019	Here, we report on photoswitchable analogs of S1P and its precursor sphingosine, respectively termed PhotoS1P and PhotoSph.	Sphingosine	68-79	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
31559137-0	2019	Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1.	Magnesium	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	76-80
31559137-7	2019	Endothelial barrier integrity is significantly enhanced with Mg2+-treatment through S1P1-Rac1 pathways and barrier-stabilizing mediators including cAMP, FGF1/2, and eNOS.	Magnesium	61-65	sphingosine-1-phosphate receptor 1	Mus musculus	84-88
31110049-2	2019	Sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate (S1P), have recently received attention for their potential roles in insulin resistance and hepatic steatosis.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	77-80
31110049-3	2019	FTY720/fingolimod, a prodrug for the treatment of multiple sclerosis, is phosphorylated in vivo to its active phosphorylated form by sphingosine kinase 2 and has been shown to interfere with the actions of S1P and to inhibit ceramide biosynthesis.	Ceramides	225-233	sphingosine-1-phosphate receptor 1	Mus musculus	206-209
31261859-1	2019	Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is recognized as a critical regulator in physiological and pathophysiological processes of atherosclerosis (AS).	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
31261859-5	2019	The results showed that S1P improved cell viability, adhesion, and nitric oxide (NO) release of EPCs in a bell-shaped manner, and migration and tube formation dose-dependently.	Nitric Oxide	67-79	sphingosine-1-phosphate receptor 1	Mus musculus	24-27
31261859-6	2019	The aforementioned beneficial effects of S1P on EPCs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor of LY294002 and nitric oxide synthase (NOS) inhibitor of N"-nitro-L-arginine-methyl ester hydrochloride (L-NAME).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	129-137	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
31261859-6	2019	The aforementioned beneficial effects of S1P on EPCs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor of LY294002 and nitric oxide synthase (NOS) inhibitor of N"-nitro-L-arginine-methyl ester hydrochloride (L-NAME).	N'-Nitro-L-arginine-methyl ester hydrochloride	183-229	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
31261859-6	2019	The aforementioned beneficial effects of S1P on EPCs could be inhibited by the phosphatidylinositol 3-kinase (PI3K) inhibitor of LY294002 and nitric oxide synthase (NOS) inhibitor of N"-nitro-L-arginine-methyl ester hydrochloride (L-NAME).	NG-Nitroarginine Methyl Ester	231-237	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
31261859-7	2019	The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	17-25	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
30963576-1	2019	Sphingosine-1-phosphate (S1P) is an essential bioactive sphingosine lipid involved in many neurological disorders.	sphingosine lipid	56-73	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30954526-2	2019	Many reports have shown that the EC barrier dysfunction is regulated by the sphingosine-1-phophate (S1P)/S1P receptor-1 (S1PR1) axis.	sphingosine-1-phophate	76-98	sphingosine-1-phosphate receptor 1	Mus musculus	121-126
30918324-4	2019	Immune-mediated pulmonary injury is aggravated by the absence of endothelial S1PR1 and alleviated by treatment with CYM-5442, suggesting a protective function of S1PR1 signaling during H1N1 infection.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	116-124	sphingosine-1-phosphate receptor 1	Mus musculus	162-167
30963819-1	2019	Background: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphKs), SphK1 and SphK2, is involved in inflammation.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
30963819-1	2019	Background: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphKs), SphK1 and SphK2, is involved in inflammation.	Sphingolipids	98-110	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
30963819-8	2019	Furthermore, an in vivo study demonstrated that blocking S1PR1 by FTY720 administration could reduce the incidence and severity of thyroiditis and goiter in SAT mice in a time-dependent manner.	Fingolimod Hydrochloride	66-72	sphingosine-1-phosphate receptor 1	Mus musculus	57-62
30611767-5	2019	Sphingosine 1-phosphate (S1P) is a pleiotropic sphingolipid which regulates fundamental cellular functions such as proliferation, survival, migration as well as processes such as development and inflammation mainly via ligation to its specific receptors S1PR (S1P1-5).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30611767-5	2019	Sphingosine 1-phosphate (S1P) is a pleiotropic sphingolipid which regulates fundamental cellular functions such as proliferation, survival, migration as well as processes such as development and inflammation mainly via ligation to its specific receptors S1PR (S1P1-5).	Sphingolipids	47-59	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30787172-2	2019	Recently, the sphingosine phosphate (S1P) signaling pathway has been implicated in tumor growth, angiogenesis, and resistance to antiangiogenic therapy.	sphingosine phosphate	14-35	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
31068460-4	2019	We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes.	sphingosine 1-phosphate	29-52	sphingosine-1-phosphate receptor 1	Mus musculus	189-211
31068460-4	2019	We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes.	sphingosine 1-phosphate	29-52	sphingosine-1-phosphate receptor 1	Mus musculus	213-218
31068460-4	2019	We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes.	sphingosine 1-phosphate	54-57	sphingosine-1-phosphate receptor 1	Mus musculus	189-211
31068460-4	2019	We now provide evidence that sphingosine-1-phosphate (S1P) generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes.	sphingosine 1-phosphate	54-57	sphingosine-1-phosphate receptor 1	Mus musculus	213-218
30629456-3	2019	When ApoM-overexpressing HIGA mice were treated with VPC23019, an antagonist against S1P receptor 1 (S1P1) and 3 (S1P3), we observed that the protective effects of ApoM were reversed, whereas JTE013, an antagonist against S1P2, did not inhibit the effects.	VPC23019	53-61	sphingosine-1-phosphate receptor 1	Mus musculus	85-99
30629456-3	2019	When ApoM-overexpressing HIGA mice were treated with VPC23019, an antagonist against S1P receptor 1 (S1P1) and 3 (S1P3), we observed that the protective effects of ApoM were reversed, whereas JTE013, an antagonist against S1P2, did not inhibit the effects.	VPC23019	53-61	sphingosine-1-phosphate receptor 1	Mus musculus	101-105
30793318-10	2019	We found that S1P in the lungs strongly activated 81.5% of nodose fibres, 70% of which were also activated by capsaicin.	Capsaicin	110-119	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
30972070-8	2019	Moreover, CCL21 was more abundant on these enlarged sinuses whereas lymph levels of sphingosine 1 phosphate (S1P) were decreased in apoE-/- mice.	sphingosine 1-phosphate	84-107	sphingosine-1-phosphate receptor 1	Mus musculus	109-112
30918324-7	2019	Combined administration of the S1PR1 agonist CYM-5442 and the antiviral drug oseltamivir provides maximum protection from ALI.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	45-53	sphingosine-1-phosphate receptor 1	Mus musculus	31-36
30188757-0	2019	Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	23-37
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	39-44
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	23-26
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	23-37
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	39-44
30484906-5	2019	Fingolimod (FTY720), a S1P receptor 1 (S1PR1) functional antagonist and FDA approved drug for relapsing-remitting multiple sclerosis, partially blunted Abeta42-induced pro-inflammatory cytokine generation, suggesting that Spns2 promotes microglia pro-inflammatory activation through S1P-signaling.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	23-26
30777331-2	2019	The lysophospholipid mediator sphingosine-1-phosphate (S1P) regulates proliferation and migration of VSMCs via S1P-specific G protein-coupled receptors, including S1P receptor 1 (S1PR1) to S1PR3.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	163-177
30777331-2	2019	The lysophospholipid mediator sphingosine-1-phosphate (S1P) regulates proliferation and migration of VSMCs via S1P-specific G protein-coupled receptors, including S1P receptor 1 (S1PR1) to S1PR3.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	179-184
30777331-2	2019	The lysophospholipid mediator sphingosine-1-phosphate (S1P) regulates proliferation and migration of VSMCs via S1P-specific G protein-coupled receptors, including S1P receptor 1 (S1PR1) to S1PR3.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	163-177
30777331-2	2019	The lysophospholipid mediator sphingosine-1-phosphate (S1P) regulates proliferation and migration of VSMCs via S1P-specific G protein-coupled receptors, including S1P receptor 1 (S1PR1) to S1PR3.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	179-184
30777331-8	2019	VSMCs from Tg-S1PR1 mice showed greater expression of interleukin-6 (IL-6) compared with nTg mouse-derived VSMCs, and administration of IL-6-neutralizing antibody into Tg-S1PR1 mice suppressed neointimal hyperplasia.	vsmcs	0-5	sphingosine-1-phosphate receptor 1	Mus musculus	11-19
30828353-9	2019	Similarly, treatment of H9C2 cardiomyoblasts with PA led to a significant increase of intracellular S1P but not in conditioned media whereas AdipoRon significantly increased S1P production and secretion from cells.	Palmitates	50-52	sphingosine-1-phosphate receptor 1	Mus musculus	100-103
30828353-11	2019	Gain and loss of function studies suggested S1P secretion and autocrine receptor activation mediated the effect of AdipoRon to attenuate PA-induced ROS production and cell death.	Palmitates	137-139	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
30828353-12	2019	Conclusion: Our data establish adiponectin signaling-mediated increase in S1P secretion as a mechanism via which HFD or PA induced cardiomyocyte lipotoxicity, leading to insulin resistance and cell death, is attenuated.	Palmitates	120-122	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
30188757-1	2019	Sphingosine-1-phosphate (S1P) is involved in the regulation of important cellular processes, including immune-cell trafficking and proliferation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30188757-3	2019	This study evaluated the effects of S1P in vitro and in vivo on the biosynthesis of leukotrienes (LTs), which form a class of lipid mediators involved in the pathogenesis of inflammatory diseases.	Leukotrienes	84-96	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
30188757-3	2019	This study evaluated the effects of S1P in vitro and in vivo on the biosynthesis of leukotrienes (LTs), which form a class of lipid mediators involved in the pathogenesis of inflammatory diseases.	Leukotrienes	98-101	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
30569161-9	2019	Furthermore, the mRNA expression levels of IL-1beta and MCP-1 were significantly elevated following addition of the S1PR1 inhibitor W146, but not by the scavenger receptor class B type I inhibitor, block lipid transport-1 (BLT-1), in apoMTg cells prior to TNF-alpha treatment.	W146	132-136	sphingosine-1-phosphate receptor 1	Mus musculus	116-121
30367841-1	2018	AIMS: The sphingolipid metabolite sphingosine 1-phosphate (S1P) has emerged as a potential cardioprotective molecule against ischemic heart disease.	Sphingolipids	10-22	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
30359564-2	2019	This generates sphingosine-1-phosphate (S1P) which can be released from the cell and activates S1P receptors on the endothelium.	sphingosine 1-phosphate	15-38	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
30359564-2	2019	This generates sphingosine-1-phosphate (S1P) which can be released from the cell and activates S1P receptors on the endothelium.	sphingosine 1-phosphate	15-38	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
30359564-9	2019	S1P induced vasodilation in denuded aortic rings was blocked by W146 but caused no vasodilation in endothelium-intact rings.	W146	64-68	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
30359564-11	2019	Generation of S1P in response to anandamide likely activates S1P1 to reduce total peripheral resistance and lower mean arterial pressure.	anandamide	33-43	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
30367841-1	2018	AIMS: The sphingolipid metabolite sphingosine 1-phosphate (S1P) has emerged as a potential cardioprotective molecule against ischemic heart disease.	sphingosine 1-phosphate	34-57	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
30566056-7	2018	Treatment of cultured cardiomyocytes with myonectin protein attenuated hypoxia/reoxygenation-induced apoptosis via S1P (sphingosine-1-phosphate)-dependent activation of cAMP/Akt cascades.	Cyclic AMP	169-173	sphingosine-1-phosphate receptor 1	Mus musculus	115-118
30563056-3	2018	In this study, we characterize two sphingosine kinases (SPHK1 and SPHK2), which phosphorylate sphingosine to S1P, and three S1P receptors (S1PR1, S1PR2 and S1PR3) in mouse and rat eyes.	Sphingosine	35-46	sphingosine-1-phosphate receptor 1	Mus musculus	109-137
30566056-8	2018	Similarly, myonectin suppressed inflammatory response to lipopolysaccharide in cultured macrophages through the S1P/cAMP/Akt-dependent signaling pathway.	Cyclic AMP	116-120	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
30273600-7	2018	Injury also led to elevated levels of sphingosine-1-phosphate (S1P), a bioactive lipid that is an important mediator of inflammation mainly through its receptor, S1P1.	sphingosine 1-phosphate	38-61	sphingosine-1-phosphate receptor 1	Mus musculus	162-166
30063084-1	2018	Hypothalamic sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled receptor 1 of sphingosine-1-phosphate, has been described as a modulator in the control of energy homeostasis in rodents.	sphingosine 1-phosphate	13-36	sphingosine-1-phosphate receptor 1	Mus musculus	49-54
30279138-5	2018	In particular, we and others have shown that sphingosine 1phosphate (S1P), formed by sphingosine kinase (SphK), is able to act as trophic and morphogenic factor in myoblasts.	sphingosine 1-phosphate	45-67	sphingosine-1-phosphate receptor 1	Mus musculus	69-72
30255127-6	2018	ieAstrocyte formation was reduced by either astrocyte-specific genetic removal of sphingosine 1-phosphate receptor 1 (S1P1) or pharmacological inhibition by fingolimod (FTY720), an FDA-approved MS medicine that can functionally antagonize S1P1.	Fingolimod Hydrochloride	157-167	sphingosine-1-phosphate receptor 1	Mus musculus	239-243
29781582-2	2018	The bioactive lipid sphingosine 1-phosphate (S1P), acting via S1P receptor 1 (S1P1 ), is a key regulator of endothelial cell (EC) barrier function.	sphingosine 1-phosphate	20-43	sphingosine-1-phosphate receptor 1	Mus musculus	62-76
29781582-2	2018	The bioactive lipid sphingosine 1-phosphate (S1P), acting via S1P receptor 1 (S1P1 ), is a key regulator of endothelial cell (EC) barrier function.	sphingosine 1-phosphate	20-43	sphingosine-1-phosphate receptor 1	Mus musculus	78-82
29903770-4	2018	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that has been shown to stimulate hepatocellular carcinoma (HCC) cell proliferation, but whether the Hippo pathway is involved in S1P-stimulated HCC cell proliferation remains to be determined.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30392766-5	2018	We found that when combined with one low dose of the S1P analog fingolimod administered into the same vaccination site posteriorly at a specific time, LDAV can elicit a primary response that reaches the level of that induced by RDAV with respect to the response magnitude and functionality.	ldav	151-155	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
30279204-1	2018	Dihydro-sphingosine 1-phosphate (DH-S1P) is an analog of sphingosine 1-phosphate (S1P), which is a potent lysophospholipid mediator.	Lysophospholipids	106-122	sphingosine-1-phosphate receptor 1	Mus musculus	8-31
30279204-1	2018	Dihydro-sphingosine 1-phosphate (DH-S1P) is an analog of sphingosine 1-phosphate (S1P), which is a potent lysophospholipid mediator.	Lysophospholipids	106-122	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
30279204-1	2018	Dihydro-sphingosine 1-phosphate (DH-S1P) is an analog of sphingosine 1-phosphate (S1P), which is a potent lysophospholipid mediator.	Lysophospholipids	106-122	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
30305119-1	2018	BACKGROUND: The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P) signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 that binds non-selectively to four of the five S1P receptors (S1P1,3,4,5).	sphingosine 1-phosphate	54-77	sphingosine-1-phosphate receptor 1	Mus musculus	235-239
29698062-0	2018	Targeted deletion of T-cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice.	Streptozocin	75-89	sphingosine-1-phosphate receptor 1	Mus musculus	28-42
29698062-4	2018	For this purpose, conditional T-cell S1P1 knockout (TS1P1KO) mice generated by crossing S1pr1loxP/loxP mice with Lck-Cre mice were used in a model of streptozotocin-induced diabetic cardiomyopathy.	Streptozocin	150-164	sphingosine-1-phosphate receptor 1	Mus musculus	37-41
29698062-8	2018	Our results indicate that T-cell S1P1 signaling activation plays a dual role in the pathogenesis of cardiac fibrosis with respect to the levels of glucose: T-cell S1P1 activation exerts antifibrotic effects in normoglycemia but exacerbates fibrosis under hyperglycemia.-Abdullah, C. S., Jin, Z.-Q.	Glucose	147-154	sphingosine-1-phosphate receptor 1	Mus musculus	33-37
29698062-9	2018	Targeted deletion of T-cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice.	Streptozocin	75-89	sphingosine-1-phosphate receptor 1	Mus musculus	28-42
29911288-4	2018	We also reported the existence of a gradient between PB and BM of a bioactive phosphosphingolipid, sphingosine-1-phosphate (S1P), which is a major PB chemottractant for BM-residing HSPCs.	phosphosphingolipid	78-97	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
30255127-6	2018	ieAstrocyte formation was reduced by either astrocyte-specific genetic removal of sphingosine 1-phosphate receptor 1 (S1P1) or pharmacological inhibition by fingolimod (FTY720), an FDA-approved MS medicine that can functionally antagonize S1P1.	Fingolimod Hydrochloride	169-175	sphingosine-1-phosphate receptor 1	Mus musculus	239-243
30082422-1	2018	Sphingosine 1-phosphate (S1P) is a bioactive signaling lipid associated with a variety of chronic pain and itch disorders.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30082422-8	2018	Here, we show that the proinflammatory lipid sphingosine 1-phosphate (S1P) and its receptor, S1P receptor 3 (S1PR3), trigger itch and pain behaviors via distinct molecular and cellular mechanisms.	sphingosine 1-phosphate	45-68	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
30229580-5	2018	RESULTS: Lack of S1P induced by sphingosine kinase inhibitor (SphKi) treatment caused beta-cell dysfunction and apoptosis, with repression of mitochondrial function shown by decreases in cellular adenosine triphosphate content, the oxygen consumption rate, the expression of oxidative phosphorylation complexes, the mitochondrial membrane potential, and the expression of key regulators of mitochondrial dynamics (mitochondrial dynamin-like GTPase [OPA1] and mitofusin 1 [MFN1]).	Oxygen	232-238	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
30229580-5	2018	RESULTS: Lack of S1P induced by sphingosine kinase inhibitor (SphKi) treatment caused beta-cell dysfunction and apoptosis, with repression of mitochondrial function shown by decreases in cellular adenosine triphosphate content, the oxygen consumption rate, the expression of oxidative phosphorylation complexes, the mitochondrial membrane potential, and the expression of key regulators of mitochondrial dynamics (mitochondrial dynamin-like GTPase [OPA1] and mitofusin 1 [MFN1]).	Adenosine Triphosphate	196-218	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
29945931-1	2018	The immunomodulatory prodrug 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol (FTY720), which acts as an agonist for sphingosine-1-phosphate (S1P) receptors (S1PR) when phosphorylated, is proposed as a novel pain therapeutic.	2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol	29-79	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
29945931-1	2018	The immunomodulatory prodrug 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol (FTY720), which acts as an agonist for sphingosine-1-phosphate (S1P) receptors (S1PR) when phosphorylated, is proposed as a novel pain therapeutic.	Fingolimod Hydrochloride	81-87	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
29945931-3	2018	FTY720 produced antinociception and antiallodynia, respectively, and these effects were dose-dependent and mimicked by the S1PR1-selective agonist CYM-5442.	Fingolimod Hydrochloride	0-6	sphingosine-1-phosphate receptor 1	Mus musculus	123-128
29945931-3	2018	FTY720 produced antinociception and antiallodynia, respectively, and these effects were dose-dependent and mimicked by the S1PR1-selective agonist CYM-5442.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	147-155	sphingosine-1-phosphate receptor 1	Mus musculus	123-128
29945931-5	2018	S1PR-stimulated [35S]GTPgammaS autoradiography revealed apparent desensitization of G protein activation by S1P or the S1PR1 agonist 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (SEW-2871) throughout the brain.	Sulfur-35	17-20	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29945931-5	2018	S1PR-stimulated [35S]GTPgammaS autoradiography revealed apparent desensitization of G protein activation by S1P or the S1PR1 agonist 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (SEW-2871) throughout the brain.	Sulfur-35	17-20	sphingosine-1-phosphate receptor 1	Mus musculus	119-124
29945931-5	2018	S1PR-stimulated [35S]GTPgammaS autoradiography revealed apparent desensitization of G protein activation by S1P or the S1PR1 agonist 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (SEW-2871) throughout the brain.	SEW2871	133-222	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29945931-5	2018	S1PR-stimulated [35S]GTPgammaS autoradiography revealed apparent desensitization of G protein activation by S1P or the S1PR1 agonist 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (SEW-2871) throughout the brain.	SEW2871	133-222	sphingosine-1-phosphate receptor 1	Mus musculus	119-124
29945931-5	2018	S1PR-stimulated [35S]GTPgammaS autoradiography revealed apparent desensitization of G protein activation by S1P or the S1PR1 agonist 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (SEW-2871) throughout the brain.	SEW2871	224-232	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29898789-6	2018	RESULTS: Co-stimulation of LPAR1 by LPA and S1PR1/3 by S1P synergistically enhanced the anti-stress ability of hADMSCs induced by chemical or ethanol incubation in vitro.	Ethanol	142-149	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
30060257-1	2018	BACKGROUND:  Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid and a constituent of high-density lipoprotein (HDL) exerting several atheroprotective effects in vitro.	Sphingolipids	58-74	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
30060257-11	2018	In addition, decreased permeability to fluorescence-labelled dextran beads or LDL was observed in S1P-treated endothelial cells.	Dextrans	61-68	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
29712716-1	2018	Apolipoprotein M (apoM) is a carrier and a modulator of sphingosine 1-phosphate (S1P), an important multifunctional bioactive lipid.	sphingosine 1-phosphate	56-79	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
29712716-4	2018	When we activated or suppressed the PPARgamma more mildly with pioglitazone or GW9662, we found that pioglitazone suppressed apoM expression and S1P synthesis, while GW9662 increased them.	Pioglitazone	101-113	sphingosine-1-phosphate receptor 1	Mus musculus	145-148
29712716-6	2018	Treatment with pioglitazone decreased both the plasma and hepatic apoM and S1P levels only in diet-induced obese mice.	Pioglitazone	15-27	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
30105025-6	2018	Living adult worms, incubated in murine plasma for 1 h, alter the plasma metabolome; a decrease in sphingosine-1-phosphate (S1P) is accompanied by an increase in the levels of its component parts-sphingosine and phosphate.	Sphingosine	99-110	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
30105025-6	2018	Living adult worms, incubated in murine plasma for 1 h, alter the plasma metabolome; a decrease in sphingosine-1-phosphate (S1P) is accompanied by an increase in the levels of its component parts-sphingosine and phosphate.	Phosphates	113-122	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
29511860-6	2018	VSMC migration was suppressed by S1PR1 inhibitor but was elevated by S1PR2 inhibitor.	vsmc	0-4	sphingosine-1-phosphate receptor 1	Mus musculus	33-38
29511860-11	2018	Our findings suggest that DJ-1 may be involved in the regulation of S1PR1 and S1PR2 expression via H2O2-mediated histone modification in VSMCs.	Hydrogen Peroxide	99-103	sphingosine-1-phosphate receptor 1	Mus musculus	68-73
29748384-3	2018	Here, we demonstrate that telomerase instability mediated by silencing of sphingosine kinase 2 (SPHK2) and sphingosine 1-phosphate (S1P), which binds and stabilizes telomerase, induces telomere damage-dependent caspase-3 activation and apoptosis, but not senescence, in p16-deficient lung cancer cells or tumors.	sphingosine 1-phosphate	107-130	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
29898789-10	2018	In a drug-induced acute liver failure model and a chronic alcoholic liver disease model, pre-conditioning with LPA and/or S1P significantly enhanced the survival ratio and the therapeutic efficacy of hADMSCs in mice, including ameliorating histological damage, oxidative stress, inflammation, fibrosis, lipid metabolism dysfunction, and enhancing alcohol metabolizing enzyme activity.	Alcohols	58-65	sphingosine-1-phosphate receptor 1	Mus musculus	122-125
29523764-1	2018	Sphingosine-1-phosphate (S1P), a bioactive sphingolipid mediator, has been implicated in regulation of many processes important for breast cancer progression.	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
30083262-10	2018	Data from murine models exhibited a marked reduction in the tumor size, increased apoptosis, inhibited NF-kappaB, S1PR1/STAT3, Shh signaling and desmoplasia, modulated the expression of gemcitabine-metabolizing transport enzymes, and restored the expression of tumor suppressor gene PP2A.	gemcitabine	186-197	sphingosine-1-phosphate receptor 1	Mus musculus	114-119
29669385-2	2018	One potential mechanism is that HDL possesses pleiotropic effects, such as anti-apoptosis, some of which can be ascribed to sphingosine 1-phosphate (S1P) carried on HDL via apolipoprotein M (apoM).	sphingosine 1-phosphate	124-147	sphingosine-1-phosphate receptor 1	Mus musculus	149-152
29134505-12	2018	This data demonstrates that [11C]TZ3321 PET provides great promise in imaging S1PR1 expression in atherosclerotic plaques.	Carbon-11	29-32	sphingosine-1-phosphate receptor 1	Mus musculus	78-83
29134505-12	2018	This data demonstrates that [11C]TZ3321 PET provides great promise in imaging S1PR1 expression in atherosclerotic plaques.	UNII-ZU57HFI5YM	33-39	sphingosine-1-phosphate receptor 1	Mus musculus	78-83
29669385-6	2018	Treatment with VPC23019, an antagonist against S1P receptor 1 and 3, or LY294002, a PI3K inhibitor, partially reversed these protective properties arising from the overexpression of apoM.	VPC23019	15-23	sphingosine-1-phosphate receptor 1	Mus musculus	47-67
29337049-4	2018	We investigated the effect of an S1P1-selective agonist SEW2871 on leptomeningeal collateral arteries and neurological outcome after pMCAO.	SEW2871	56-63	sphingosine-1-phosphate receptor 1	Mus musculus	33-37
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Bortezomib	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	147-187
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Bortezomib	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	189-194
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Bortezomib	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Bortezomib	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	189-192
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Sphingolipids	66-78	sphingosine-1-phosphate receptor 1	Mus musculus	147-187
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Sphingolipids	66-78	sphingosine-1-phosphate receptor 1	Mus musculus	189-194
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Sphingolipids	66-78	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
29703731-2	2018	We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P.	Sphingolipids	66-78	sphingosine-1-phosphate receptor 1	Mus musculus	189-192
29662200-8	2018	Furthermore, serum S1P levels were positively associated with serum calcium , negatively with PTH , and curvilinearly with body mass index.	Calcium	68-75	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
29787576-2	2018	S1P is produced via intracellular phosphorylation of sphingosine (Sph).	Sphingosine	53-64	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29787576-2	2018	S1P is produced via intracellular phosphorylation of sphingosine (Sph).	Sphingosine	66-69	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29757216-4	2018	Herein, we observed lower sphingosine-1-phosphate receptor 1 (S1P1) expression in NOD mouse thymocytes when compared with controls, mainly in the mature SP CD4+CD62Lhi and CD8+CD62Lhi subpopulations bearing the CD49e&amp;minus; phenotype.	sp	153-155	sphingosine-1-phosphate receptor 1	Mus musculus	26-60
29757216-4	2018	Herein, we observed lower sphingosine-1-phosphate receptor 1 (S1P1) expression in NOD mouse thymocytes when compared with controls, mainly in the mature SP CD4+CD62Lhi and CD8+CD62Lhi subpopulations bearing the CD49e&amp;minus; phenotype.	sp	153-155	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
29757216-4	2018	Herein, we observed lower sphingosine-1-phosphate receptor 1 (S1P1) expression in NOD mouse thymocytes when compared with controls, mainly in the mature SP CD4+CD62Lhi and CD8+CD62Lhi subpopulations bearing the CD49e&amp;minus; phenotype.	Adenosine Monophosphate	217-220	sphingosine-1-phosphate receptor 1	Mus musculus	26-60
29757216-4	2018	Herein, we observed lower sphingosine-1-phosphate receptor 1 (S1P1) expression in NOD mouse thymocytes when compared with controls, mainly in the mature SP CD4+CD62Lhi and CD8+CD62Lhi subpopulations bearing the CD49e&amp;minus; phenotype.	Adenosine Monophosphate	217-220	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
29757216-7	2018	We further noticed a decreased expression of the sphingosine-1-phosphate lyase (SGPL1) in NOD SP thymocytes, which can lead to a higher sphingosine-1-phosphate (S1P) expression around PVS and S1P1 internalization.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	192-196
29555645-5	2018	Enforced expression of S1PR1 or clustered regularly interspaced short palindromic repeats/Cas9-mediated genome editing of the miR-125b targeting site in the S1PR1 3" untranslated region rescued the miR-125b-mediated defect in B-cell egress.	mir-125b	126-134	sphingosine-1-phosphate receptor 1	Mus musculus	23-28
29555645-5	2018	Enforced expression of S1PR1 or clustered regularly interspaced short palindromic repeats/Cas9-mediated genome editing of the miR-125b targeting site in the S1PR1 3" untranslated region rescued the miR-125b-mediated defect in B-cell egress.	mir-125b	126-134	sphingosine-1-phosphate receptor 1	Mus musculus	157-162
29555645-5	2018	Enforced expression of S1PR1 or clustered regularly interspaced short palindromic repeats/Cas9-mediated genome editing of the miR-125b targeting site in the S1PR1 3" untranslated region rescued the miR-125b-mediated defect in B-cell egress.	mir-125b	198-206	sphingosine-1-phosphate receptor 1	Mus musculus	23-28
29555645-5	2018	Enforced expression of S1PR1 or clustered regularly interspaced short palindromic repeats/Cas9-mediated genome editing of the miR-125b targeting site in the S1PR1 3" untranslated region rescued the miR-125b-mediated defect in B-cell egress.	mir-125b	198-206	sphingosine-1-phosphate receptor 1	Mus musculus	157-162
29604582-1	2018	Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups.	Azetidinecarboxylic Acid	107-134	sphingosine-1-phosphate receptor 1	Mus musculus	13-47
29604582-1	2018	Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups.	Azetidinecarboxylic Acid	107-134	sphingosine-1-phosphate receptor 1	Mus musculus	49-54
29693558-2	2018	Cross-linking of the high-affinity receptor for IgE (Fc&amp;epsilon;RI) on mast cells leads to the generation and secretion of the sphingolipid mediator, sphingosine-1-phosphate (S1P) which is able, in turn, to transactivate its receptors on mast cells.	Sphingolipids	131-143	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
29351902-2	2018	Here, we show that in breast cancer patients and in animal breast cancer models, obesity is a sufficient cause for increased expression of the bioactive sphingolipid mediator sphingosine-1-phosphate (S1P), which mediates cancer pathogenesis.	Sphingolipids	153-165	sphingosine-1-phosphate receptor 1	Mus musculus	200-203
29693558-3	2018	Previous reports have identified the expression of two of the five receptors for S1P on mast cells, S1P1 and S1P2, with functions in Fc&amp;epsilon;RI-mediated chemotaxis and degranulation, respectively.	Adenosine Monophosphate	136-139	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
29693558-3	2018	Previous reports have identified the expression of two of the five receptors for S1P on mast cells, S1P1 and S1P2, with functions in Fc&amp;epsilon;RI-mediated chemotaxis and degranulation, respectively.	Adenosine Monophosphate	136-139	sphingosine-1-phosphate receptor 1	Mus musculus	100-113
29608575-0	2018	Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus.	ozanimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	32-37
29351902-2	2018	Here, we show that in breast cancer patients and in animal breast cancer models, obesity is a sufficient cause for increased expression of the bioactive sphingolipid mediator sphingosine-1-phosphate (S1P), which mediates cancer pathogenesis.	sphingosine 1-phosphate	175-198	sphingosine-1-phosphate receptor 1	Mus musculus	200-203
29351902-8	2018	Taken together, our results establish a critical role for circulating S1P produced by tumors and the SphK1/S1P/S1PR1 axis in obesity-related inflammation, formation of lung metastatic niches, and breast cancer metastasis, with potential implications for prevention and treatment.Significance: These findings offer a preclinical proof of concept that signaling by a sphingolipid may be an effective target to prevent obesity-related breast cancer metastasis.	Sphingolipids	365-377	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
29563527-1	2018	Sphingosine 1-phosphate (S1P) is an intercellular signaling molecule present in blood.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29536159-7	2018	Furthermore, in females, lung resistance following methacholine challenge correlated with lung S1P levels (Pearson correlation coefficient 0.57) suggesting a link between reduced AHR in KO females, Zpbp2 deletion, and S1P level regulation.	Methacholine Chloride	51-63	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
29536159-7	2018	Furthermore, in females, lung resistance following methacholine challenge correlated with lung S1P levels (Pearson correlation coefficient 0.57) suggesting a link between reduced AHR in KO females, Zpbp2 deletion, and S1P level regulation.	Methacholine Chloride	51-63	sphingosine-1-phosphate receptor 1	Mus musculus	218-221
29561262-3	2018	Here, we show that the bioactive lipid sphingosine 1-phosphate (S1P) and S1P Receptor 3 (S1PR3) are critical regulators of acute mechanonociception.	sphingosine 1-phosphate	39-62	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
29415945-3	2018	Sphingolipid sphingosine-1-phosphate (S1P) is a lysophospholipid regulator modulating a variety of immune cell trafficking via interactions with its cognate receptors, S1P1-5.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
29415945-3	2018	Sphingolipid sphingosine-1-phosphate (S1P) is a lysophospholipid regulator modulating a variety of immune cell trafficking via interactions with its cognate receptors, S1P1-5.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	168-174
29415945-3	2018	Sphingolipid sphingosine-1-phosphate (S1P) is a lysophospholipid regulator modulating a variety of immune cell trafficking via interactions with its cognate receptors, S1P1-5.	Lysophospholipids	48-64	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
29415945-3	2018	Sphingolipid sphingosine-1-phosphate (S1P) is a lysophospholipid regulator modulating a variety of immune cell trafficking via interactions with its cognate receptors, S1P1-5.	Lysophospholipids	48-64	sphingosine-1-phosphate receptor 1	Mus musculus	168-174
29563527-3	2018	We previously demonstrated that S1P is exported from erythrocytes by a glyburide-sensitive S1P transporter.	Glyburide	71-80	sphingosine-1-phosphate receptor 1	Mus musculus	32-35
29563527-3	2018	We previously demonstrated that S1P is exported from erythrocytes by a glyburide-sensitive S1P transporter.	Glyburide	71-80	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
29193293-8	2018	Our study identifies functional antagonism of S1PR1 as a major mechanism for the protective effect of FTY720 in the cuprizone model and suggests pathogenic contributions of astrocyte S1PR1 signaling in primary demyelination and its potential as a therapeutic target for CNS inflammation.	Cuprizone	116-125	sphingosine-1-phosphate receptor 1	Mus musculus	46-51
29193293-0	2018	Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.	Cuprizone	69-78	sphingosine-1-phosphate receptor 1	Mus musculus	25-59
29193293-6	2018	Interestingly, S1PR1 modulation during the early phase of cuprizone intoxication was required to suppress oligodendrocyte death and consequent demyelination as drug treatment from 10 days after the initiation of cuprizone feeding was no longer effective.	Cuprizone	58-67	sphingosine-1-phosphate receptor 1	Mus musculus	15-20
29193293-6	2018	Interestingly, S1PR1 modulation during the early phase of cuprizone intoxication was required to suppress oligodendrocyte death and consequent demyelination as drug treatment from 10 days after the initiation of cuprizone feeding was no longer effective.	Cuprizone	212-221	sphingosine-1-phosphate receptor 1	Mus musculus	15-20
29205338-0	2018	S1P receptor antagonists fingolimod and siponimod do not improve the outcome of experimental autoimmune myasthenia gravis mice after disease onset.	Fingolimod Hydrochloride	25-35	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
29205338-3	2018	Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG.	Fingolimod Hydrochloride	58-68	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
29205338-3	2018	Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG.	siponimod	73-82	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
29205338-3	2018	Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG.	siponimod	84-90	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
29205338-3	2018	Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG.	Fingolimod Hydrochloride	159-169	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
29205338-3	2018	Functional sphingosine-1-phosphate (S1P) antagonists like fingolimod and siponimod (BAF312) are successfully used for the treatment of multiple sclerosis, and fingolimod was shown to prevent the development of myasthenic symptoms in experimental autoimmune myasthenia gravis (EAMG), the standard model of MG.	eamg	276-280	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
29479306-1	2018	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in numerous physiological and pathophysiological processes.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29260347-7	2018	Moreover, when apoM+/+ mice were treated with W146, a S1P receptor (S1PR1) antagonist, these inflammatory biomarkers could be significantly upregulated by LPS-induced ALI.	W146	46-50	sphingosine-1-phosphate receptor 1	Mus musculus	54-57
29260347-7	2018	Moreover, when apoM+/+ mice were treated with W146, a S1P receptor (S1PR1) antagonist, these inflammatory biomarkers could be significantly upregulated by LPS-induced ALI.	W146	46-50	sphingosine-1-phosphate receptor 1	Mus musculus	68-73
29286094-5	2018	Furthermore, in cultured H9c2 cells exposed to phenylephrine, S1P was revealed to decrease cardiomyocyte size and the exaggerated expression of fetal cardiac genes.	Phenylephrine	47-60	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29479306-2	2018	We have previously reported a S1P-induced nocifensive response in mice by excitation of sensory neurons via activation of an excitatory chloride current.	Chlorides	136-144	sphingosine-1-phosphate receptor 1	Mus musculus	30-33
29479306-3	2018	The underlying molecular mechanism for the S1P-induced chloride conductance remains elusive.	Chlorides	55-63	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
29479306-6	2018	The mechanism of S1P-induced activation of the chloride current involved Rho GTPase but not Rho-associated protein kinase.	Chlorides	47-55	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
29392309-2	2018	Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes, including cell survival, proliferation, inflammation, migration, and angiogenesis.	sphingosine 1-phosphate	10-33	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
29055687-2	2018	Over the last two decades, sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes important for breast cancer including growth, progression, transformation and metastasis, and is the focus of this review.	sphingosine 1-phosphate	27-50	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
29140922-0	2018	Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	90-124
29140922-3	2018	We explored the analgesic potential of fingolimod (FTY720), an agonist and/or functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain.	Fingolimod Hydrochloride	39-49	sphingosine-1-phosphate receptor 1	Mus musculus	107-141
29140922-3	2018	We explored the analgesic potential of fingolimod (FTY720), an agonist and/or functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain.	Fingolimod Hydrochloride	39-49	sphingosine-1-phosphate receptor 1	Mus musculus	143-148
29140922-3	2018	We explored the analgesic potential of fingolimod (FTY720), an agonist and/or functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain.	Fingolimod Hydrochloride	51-57	sphingosine-1-phosphate receptor 1	Mus musculus	143-148
29140922-8	2018	The antihyperalgesic effects of fingolimod were prevented or reversed by the S1PR1 antagonist W146 (1 mg/kg daily, i.p.)	Fingolimod Hydrochloride	32-42	sphingosine-1-phosphate receptor 1	Mus musculus	77-82
29140922-8	2018	The antihyperalgesic effects of fingolimod were prevented or reversed by the S1PR1 antagonist W146 (1 mg/kg daily, i.p.)	W146	94-98	sphingosine-1-phosphate receptor 1	Mus musculus	77-82
29140922-9	2018	and could be mimicked by either repeated or single injection of the S1PR1-selective agonist SEW2871.	SEW2871	92-99	sphingosine-1-phosphate receptor 1	Mus musculus	68-73
29140922-11	2018	We conclude that fingolimod behaves as an S1PR1 agonist to reduce pain in multiple sclerosis by reversing central sensitization of spinal nociceptive neurons.	Fingolimod Hydrochloride	17-27	sphingosine-1-phosphate receptor 1	Mus musculus	42-47
29336057-2	2018	2-Acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase, exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear.	2-acetyl-4(5)-tetrahydroxybutylimidazole	0-38	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29336057-2	2018	2-Acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase, exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear.	2-acetyl-4(5)-tetrahydroxybutylimidazole	0-38	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
29336057-2	2018	2-Acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase, exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear.	2-acetyl-4(5)-tetrahydroxybutylimidazole	40-43	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29336057-2	2018	2-Acetyl-4-tetrahydroxybutyl imidazole (THI), an inhibitor of S1P lyase, exhibits immunomodulatory activity through increasing the S1P concentration in the secondary lymphoid organs, but its effects on colitis remain unclear.	2-acetyl-4(5)-tetrahydroxybutylimidazole	40-43	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
29273365-3	2018	The present study aimed to clarify whether SEW2871, a selective S1PR1 agonist, can attenuate hepatic damage caused by hepatic IRI, focusing on SEC functions.	SEW2871	43-50	sphingosine-1-phosphate receptor 1	Mus musculus	64-69
29237776-1	2018	The role of sphingosine-1 phosphate (S1P) in leukocyte trafficking has been well deciphered in mice but remains largely unaddressed in humans.	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
29298420-0	2018	The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.	Triglycerides	39-51	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
29055687-2	2018	Over the last two decades, sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes important for breast cancer including growth, progression, transformation and metastasis, and is the focus of this review.	Sphingolipids	67-79	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	ptx	265-268	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	ptx	14-17	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	272-280	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	ptx	14-17	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
28540559-3	2018	The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically as well as antagonistically on embryonic stem (ES) cell differentiation.	sphingolipid ceramide	4-25	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	pyrazolanthrone	78-86	sphingosine-1-phosphate receptor 1	Mus musculus	168-171
30231248-7	2018	We found that PTX (inhibitor of G(alpha)i/o), LY294002 (inhibitor of PI3K) or SP600125 (inhibitor of JNK1/2) prevented up-regulation of M1 genes expression mediated by S1P/S1PR2/3 signal, and S1P-induced JNK phosphorylation was inhibited by antagonists of S1PR2/3, PTX or LY294002.	pyrazolanthrone	78-86	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
29384055-6	2018	ET-1 activates the sphingosine kinase/sphingosine-1-phosphate (SphK/S1P) pathway.	sphingosine 1-phosphate	38-61	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
29023711-2	2018	A decrease in the sphingosine-1-phosphate (S1P) blood levels has been shown in patients and in animal models of sepsis.	sphingosine 1-phosphate	18-41	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
29285771-7	2018	The implications of disturbed sphingolipid metabolism for the pathogenesis of septic encephalopathy will depend on the net impact of these changes on S1P receptor signaling at the BBB and the importance of the S1P pathway in regulating vascular homeostasis in this context.	Sphingolipids	30-42	sphingosine-1-phosphate receptor 1	Mus musculus	150-153
29304533-5	2018	Transport studies in membrane vesicles of Sf9 cells containing recombinant human MRP4 revealed that MRP4 mediates ATP-dependent transport of fluorescein- and tritium-labelled S1P.	Tritium	158-165	sphingosine-1-phosphate receptor 1	Mus musculus	175-178
29304533-6	2018	Also, ATP-dependent S1P transport in platelet membrane vesicles containing endogenous MRP4 was inhibited by the MRP inhibitor MK571 and the MRP4-selective compound Ceefourin-1.	Adenosine Triphosphate	6-9	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
29304533-1	2018	Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29304533-6	2018	Also, ATP-dependent S1P transport in platelet membrane vesicles containing endogenous MRP4 was inhibited by the MRP inhibitor MK571 and the MRP4-selective compound Ceefourin-1.	verlukast	126-131	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
29304533-1	2018	Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism.	Adenosine Triphosphate	97-119	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29304533-1	2018	Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism.	Adenosine Triphosphate	121-124	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29304533-5	2018	Transport studies in membrane vesicles of Sf9 cells containing recombinant human MRP4 revealed that MRP4 mediates ATP-dependent transport of fluorescein- and tritium-labelled S1P.	Adenosine Triphosphate	114-117	sphingosine-1-phosphate receptor 1	Mus musculus	175-178
29304533-6	2018	Also, ATP-dependent S1P transport in platelet membrane vesicles containing endogenous MRP4 was inhibited by the MRP inhibitor MK571 and the MRP4-selective compound Ceefourin-1.	ceefourin 1	164-175	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
29304533-7	2018	Confocal microscopy using fluorescein-labelled S1P as well as boron-dipyrromethene (BODIPY)-labelled sphingosine indicated association of S1P and MRP4 in human platelets.	Boron dipyrromethene	62-82	sphingosine-1-phosphate receptor 1	Mus musculus	138-141
29304533-7	2018	Confocal microscopy using fluorescein-labelled S1P as well as boron-dipyrromethene (BODIPY)-labelled sphingosine indicated association of S1P and MRP4 in human platelets.	Sphingosine	101-112	sphingosine-1-phosphate receptor 1	Mus musculus	138-141
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Fluvastatin	0-11	sphingosine-1-phosphate receptor 1	Mus musculus	184-187
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Fluvastatin	0-11	sphingosine-1-phosphate receptor 1	Mus musculus	247-250
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Rosuvastatin Calcium	16-28	sphingosine-1-phosphate receptor 1	Mus musculus	184-187
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Rosuvastatin Calcium	16-28	sphingosine-1-phosphate receptor 1	Mus musculus	247-250
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Adenosine Triphosphate	70-73	sphingosine-1-phosphate receptor 1	Mus musculus	184-187
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Adenosine Triphosphate	70-73	sphingosine-1-phosphate receptor 1	Mus musculus	247-250
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Cyclic GMP	84-88	sphingosine-1-phosphate receptor 1	Mus musculus	184-187
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Cyclic GMP	84-88	sphingosine-1-phosphate receptor 1	Mus musculus	247-250
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Cyclic GMP	90-120	sphingosine-1-phosphate receptor 1	Mus musculus	184-187
29304533-9	2018	Fluvastatin and rosuvastatin interfered with MRP4 function inhibiting ATP-dependent cGMP (cyclic guanosine monophosphate) uptake into MRP4-containing vesicles, inhibited MRP4-mediated S1P transport in vitro and significantly attenuated endogenous S1P release from agonist-activated platelet ex vivo.	Cyclic GMP	90-120	sphingosine-1-phosphate receptor 1	Mus musculus	247-250
29244772-5	2017	Examination of macrophages in culture revealed that the sphingosine-1-phosphate receptor 1 selective agonist, SEW2871 or high density lipoprotein (HDL), protected macrophages against apoptosis induced by endoplasmic reticulum (ER) stress or oxidized LDL, through activation of phosphatidylinositol-3-kinase/Akt signaling.	SEW2871	110-117	sphingosine-1-phosphate receptor 1	Mus musculus	56-90
29028945-1	2017	Accumulating evidence suggests that the sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) pathway plays a pivotal role in colon carcinogenesis.	sphingosine 1-phosphate	69-92	sphingosine-1-phosphate receptor 1	Mus musculus	94-97
29221156-7	2017	Immunohistochemical staining of tumours ex vivo revealed disrupted patterns of VE-cadherin in vasculature of mice treated with CA4P, which were decreased by pretreatment with S1P.	CA4P	127-131	sphingosine-1-phosphate receptor 1	Mus musculus	175-178
29028945-2	2017	Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least by regulating cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production.	Dinoprostone	150-166	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
29028945-2	2017	Our previous studies indicate that the SphK1/S1P pathway mediates colon carcinogenesis at least by regulating cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production.	Dinoprostone	168-172	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
29028945-9	2017	Intraperitoneal injection of sphingolipids demonstrates that S1P enhanced AOM-induced ACF formation, while ceramide inhibited.	Sphingolipids	29-42	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
29078883-8	2017	In a murine breast cancer model, sphingosine kinase 1, S1P receptor 1, interleukin 6, and STAT3 were overexpressed in the doxorubicin-treated group, whereas all of them were significantly suppressed with addition of FTY720.	Doxorubicin	122-133	sphingosine-1-phosphate receptor 1	Mus musculus	55-69
29093714-1	2017	Sphingosine-1-phosphate (S1P) levels significantly increase in bronchoalveolar lavage (BAL) of asthmatic patients following segmental allergen challenge and this increase well correlates with pulmonary inflammation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
29120624-5	2017	Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of 13n as a clinical candidate that exhibited &gt;30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing).	Nitrogen-13	189-192	sphingosine-1-phosphate receptor 1	Mus musculus	264-268
29226621-0	2017	Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties.	jervine	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	29-33
29226621-5	2017	Here, we describe the discovery of cenerimod, a novel, potent and selective S1P1 receptor modulator with unique S1P1 receptor signaling properties and absence of broncho- and vasoconstrictor effects ex vivo and in vivo.	jervine	35-44	sphingosine-1-phosphate receptor 1	Mus musculus	76-80
29226621-5	2017	Here, we describe the discovery of cenerimod, a novel, potent and selective S1P1 receptor modulator with unique S1P1 receptor signaling properties and absence of broncho- and vasoconstrictor effects ex vivo and in vivo.	jervine	35-44	sphingosine-1-phosphate receptor 1	Mus musculus	112-116
29018225-2	2017	Although S1P1 agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P1 signaling regulates Th17 and Treg cell homeostasis.	Fingolimod Hydrochloride	22-32	sphingosine-1-phosphate receptor 1	Mus musculus	9-13
28846923-8	2017	Pharmacological inhibition of the S1P generating sphingosine kinases, by 4- [[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol (SK I-II), administered directly following CLP, prevented thymus atrophy.	4-((4-(4-chlorophenyl)-2-thiazolyl)amino)phenol	73-121	sphingosine-1-phosphate receptor 1	Mus musculus	34-37
28846923-8	2017	Pharmacological inhibition of the S1P generating sphingosine kinases, by 4- [[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol (SK I-II), administered directly following CLP, prevented thymus atrophy.	sk i-ii	123-130	sphingosine-1-phosphate receptor 1	Mus musculus	34-37
29221156-2	2017	The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/beta-catenin complexes.	Sphingolipids	14-26	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
29221156-5	2017	Intravenously administered S1P (8mg/kg/hr for 20 minutes then 2mg/kg/hr for 40 minutes), reduced CA4P-induced (30mg/kg) blood flow shut-down in fibrosarcoma tumours in SCID mice (n&gt;=7 per group), as measured by tumour retention of an intravenously administered fluorescent lectin.	CA4P	97-101	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
28894119-5	2017	Ceramides act as a double-edged sword, promoting normal skin homeostasis in the native state, but can be metabolized to sphingosine-1-phosphate (S1P), linked to inflammation and tumorigenesis.	Ceramides	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	145-148
29221156-3	2017	We tested the hypothesis that tumour pre-treatment with S1P would render tumours less susceptible to CA4P.	CA4P	101-105	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
29221156-4	2017	S1P (1muM) pretreatment attenuated an increase in endothelial cell (HUVEC) monolayer permeability induced by 10muM CA4P.	CA4P	115-119	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
28625547-2	2017	S1P signalling enhances presynaptic glutamate release and is essential for neural development.	Glutamic Acid	36-45	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
28811382-3	2017	Apolipoprotein M-containing HDL (ApoM+HDL), which carries the bioactive lipid sphingosine 1-phosphate (S1P), promotes endothelial function by activating G protein-coupled S1P receptors.	sphingosine 1-phosphate	78-101	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
28570482-3	2017	Following femoral arthrotomy and syngenic tumor implantation in mice, ceramides decreased with corresponding increases in sphingosine and the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	177-200	sphingosine-1-phosphate receptor 1	Mus musculus	202-205
28570482-4	2017	Intriguingly, de novo sphingolipid biosynthesis was increased as shown by the elevations of dihydro-ceramides and dihydro-S1P.	Sphingolipids	22-34	sphingosine-1-phosphate receptor 1	Mus musculus	122-125
28570482-10	2017	Studies here identify a novel mechanism to inhibit bone cancer pain by blocking the actions of the bioactive metabolites S1P and dihydro-S1P in lumbar spinal cord induced by bone cancer and support potential fast-track clinical application of the FDA-approved drug, FTY720, as a therapeutic avenue for CIBP.	cibp	302-306	sphingosine-1-phosphate receptor 1	Mus musculus	121-124
28570482-10	2017	Studies here identify a novel mechanism to inhibit bone cancer pain by blocking the actions of the bioactive metabolites S1P and dihydro-S1P in lumbar spinal cord induced by bone cancer and support potential fast-track clinical application of the FDA-approved drug, FTY720, as a therapeutic avenue for CIBP.	cibp	302-306	sphingosine-1-phosphate receptor 1	Mus musculus	137-140
29088837-1	2017	Sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR) signaling pathway has been implicated in a variety of pathological processes of ovarian cancer.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
29088837-1	2017	Sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR) signaling pathway has been implicated in a variety of pathological processes of ovarian cancer.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
28811382-3	2017	Apolipoprotein M-containing HDL (ApoM+HDL), which carries the bioactive lipid sphingosine 1-phosphate (S1P), promotes endothelial function by activating G protein-coupled S1P receptors.	sphingosine 1-phosphate	78-101	sphingosine-1-phosphate receptor 1	Mus musculus	171-174
28771545-2	2017	The lysophospholipid mediator sphigosine-1-phosphate (S1P) regulates functions of cardiovascular cells through multiple receptors including S1PR1-S1PR3.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	140-145
28771545-2	2017	The lysophospholipid mediator sphigosine-1-phosphate (S1P) regulates functions of cardiovascular cells through multiple receptors including S1PR1-S1PR3.	sphigosine-1-phosphate	30-52	sphingosine-1-phosphate receptor 1	Mus musculus	140-145
28607130-6	2017	The specific loss of endothelial S1PR1 decreases basal and stimulated endothelial-derived nitric oxide and resets BP to a higher-than-normal value.	Nitric Oxide	90-102	sphingosine-1-phosphate receptor 1	Mus musculus	33-38
28607130-9	2017	Our study identifies S1P-S1PR1-nitric oxide signaling as a new regulatory pathway in vivo of vascular relaxation to flow and BP homeostasis, providing a novel therapeutic target for the treatment of hypertension.	Nitric Oxide	31-43	sphingosine-1-phosphate receptor 1	Mus musculus	25-30
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	tetrahydroxybutylimidazole	82-108	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	tetrahydroxybutylimidazole	82-108	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	tetrahydroxybutylimidazole	82-108	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	2-acetyl-4(5)-tetrahydroxybutylimidazole	110-113	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	2-acetyl-4(5)-tetrahydroxybutylimidazole	110-113	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	2-acetyl-4(5)-tetrahydroxybutylimidazole	110-113	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	Lead	190-192	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	Lead	190-192	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
29029455-6	2017	We also administered an inhibitor of the S1P-degrading enzyme S1P lyase, known as tetrahydroxybutylimidazole (THI), to WT mice and observed that this resulted in an increase in S1P level in PB and enhanced mobilization of HSPCs.	Lead	190-192	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
28511328-1	2017	Objective: To investigate the effects of apolipoprotein E deficiency (Apo E(-/-)) on plasma and lipoprotein distribution of sphingosine-1-phosphate (S1P) in mice.	sphingosine 1-phosphate	124-147	sphingosine-1-phosphate receptor 1	Mus musculus	149-152
28683966-9	2017	Mechanistically, we found that Meto-induced S1P secretion is beta3AR-dependent because Meto infusion in beta3AR knockout mice does not elevate circulating S1P levels, nor does it ameliorate post-MI dysfunction, as in wild-type mice.	Metoprolol	31-35	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
28139067-5	2017	Pathway analysis revealed that graded CR had an impact on carnitine synthesis and the carnitine shuttle pathway, sphingosine-1-phosphate (S1P) signalling and methionine metabolism.	Chromium	38-40	sphingosine-1-phosphate receptor 1	Mus musculus	138-141
27942751-1	2017	OBJECTIVES: Sphingosine 1-phosphate (S1P) is a bioactive lipid that binds to cell surface receptors (S1P1-5).	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	101-107
28188805-4	2017	Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid that plays key role in the regulation of many physiological and pathological functions.	Sphingolipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28494002-1	2017	Sphingosine 1-phosphate (S1P) is a bioactive lipid mediator that is thought to be involved in various diseases.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28494002-3	2017	When we differentiated K562 cells into erythroblast-like cells with sodium butyrate, we observed that the efflux of S1P was increased without increased expression of previously proposed S1P transporters, while the expression levels of Band3 were increased.	Butyric Acid	68-83	sphingosine-1-phosphate receptor 1	Mus musculus	116-119
28494002-4	2017	Therefore, in this study, we investigated the involvement of Band 3, the most characteristic membranous transporter for erythrocytes, in S1P efflux, using 4,4"-diisothiocyanatodihydrostilbene-2,2"-disulfonic acid, disodium salt (H2DIDS), which is an inhibitor of Band3.	4,4"-diisothiocyanatodihydrostilbene-2,2"-disulfonic acid	155-212	sphingosine-1-phosphate receptor 1	Mus musculus	137-140
28494002-6	2017	Next, when we injected H2DIDS into mice, the plasma S1P level was significantly decreased.	dihydro-DIDS	23-29	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
28494002-8	2017	These results suggested the possible involvement of Band3 in the transport of S1P, a multi-functional bioactive phospholipid, from erythrocytes.	Phospholipids	112-124	sphingosine-1-phosphate receptor 1	Mus musculus	78-81
28198542-3	2017	Several studies demonstrated that ceramide synthase 2 (Cers2) regulates the levels of the S1P precursor sphingosine.	Sphingosine	104-115	sphingosine-1-phosphate receptor 1	Mus musculus	90-93
27942751-1	2017	OBJECTIVES: Sphingosine 1-phosphate (S1P) is a bioactive lipid that binds to cell surface receptors (S1P1-5).	sphingosine 1-phosphate	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	101-107
27942751-2	2017	In this study, we examined the effect of S1P1 agonist, ONO-W061, on murine Candida albicans water-soluble fraction (CAWS)-induced vasculitis.	ono-w061	55-63	sphingosine-1-phosphate receptor 1	Mus musculus	41-45
27942751-2	2017	In this study, we examined the effect of S1P1 agonist, ONO-W061, on murine Candida albicans water-soluble fraction (CAWS)-induced vasculitis.	Water	92-97	sphingosine-1-phosphate receptor 1	Mus musculus	41-45
27801960-0	2017	Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells.	Melatonin	49-58	sphingosine-1-phosphate receptor 1	Mus musculus	24-27
26843200-0	2017	A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.	Carbon-11	12-21	sphingosine-1-phosphate receptor 1	Mus musculus	30-64
26843200-3	2017	METHODS: The S1PR1 compound TZ3321 was synthesized for in vitro characterization and labeled with Carbon-11 for in vivo studies.	Carbon-11	98-107	sphingosine-1-phosphate receptor 1	Mus musculus	13-18
26843200-5	2017	RESULTS: The high potency of TZ3321 for S1PR1 (IC 50 = 2.13 +- 1.63 nM), and high selectivity (&gt;1000 nM) for S1PR1 over S1PR2 and S1PR3 were confirmed.	UNII-ZU57HFI5YM	29-35	sphingosine-1-phosphate receptor 1	Mus musculus	40-45
26843200-5	2017	RESULTS: The high potency of TZ3321 for S1PR1 (IC 50 = 2.13 +- 1.63 nM), and high selectivity (&gt;1000 nM) for S1PR1 over S1PR2 and S1PR3 were confirmed.	UNII-ZU57HFI5YM	29-35	sphingosine-1-phosphate receptor 1	Mus musculus	112-117
26843200-6	2017	Biodistribution data revealed prolonged retention of [11C]TZ3321 in S1PR1-enriched tissues.	Carbon-11	54-57	sphingosine-1-phosphate receptor 1	Mus musculus	68-73
28680571-5	2017	In vivo, transcription and expression of S1PR1 and KLF2 in mice lungs were detected by microarray profiling and immunoblotting after exposure to simvastatin (10 mg/kg).	Simvastatin	145-156	sphingosine-1-phosphate receptor 1	Mus musculus	41-46
28262793-0	2017	Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.	Cholesterol	20-31	sphingosine-1-phosphate receptor 1	Mus musculus	47-70
28262793-1	2017	Sphingosine-1-phosphate (S1P) lyase irreversibly cleaves S1P, thereby catalysing the ultimate step of sphingolipid degradation.	Sphingolipids	102-114	sphingosine-1-phosphate receptor 1	Mus musculus	0-23
28262793-1	2017	Sphingosine-1-phosphate (S1P) lyase irreversibly cleaves S1P, thereby catalysing the ultimate step of sphingolipid degradation.	Sphingolipids	102-114	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28262793-1	2017	Sphingosine-1-phosphate (S1P) lyase irreversibly cleaves S1P, thereby catalysing the ultimate step of sphingolipid degradation.	Sphingolipids	102-114	sphingosine-1-phosphate receptor 1	Mus musculus	57-60
28262793-2	2017	We show here that embryonic fibroblasts from S1P lyase-deficient mice (Sgpl1-/--MEFs), in which S1P and sphingosine accumulate, have features of Niemann-Pick disease type C (NPC) cells.	Sphingosine	104-115	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
28126827-1	2017	OBJECTIVE: Sphingosine-1-phosphate (S1P) is a vasoprotective lipid mediator.	sphingosine 1-phosphate	11-34	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
28039158-3	2017	Therefore, we hypothesized that FTY720, an S1P antagonist, would ameliorate NASH by inhibiting proinflammatory monocyte chemotaxis.	Fingolimod Hydrochloride	32-38	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
27574180-1	2017	The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues.	Lysophospholipids	14-30	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
27574180-1	2017	The bioactive lysophospholipid sphingosine-1-phosphate (S1P) is best known for its activity as T-cell-active chemoattractant regulating the egress of T cells from the lymph node and, consequently, the availability of T cells for migration into peripheral tissues.	sphingosine 1-phosphate	31-54	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
27543493-1	2017	Sphingosine 1-phosphate (S1P) participates in migration of bone marrow (BM)-derived mesenchymal stem cells (BMSCs) toward damaged liver via upregulation of S1P receptor 3 (S1PR3) during mouse liver fibrogenesis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28017639-1	2017	Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, is generated and released at sites of tissue injury in the heart and can act on S1P1, S1P2, and S1P3 receptor subtypes to affect cardiovascular responses.	Lysophospholipids	43-59	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28367448-4	2017	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protein coupled receptors (S1P1-5) in order to influence a broad spectrum of biological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28367448-4	2017	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protein coupled receptors (S1P1-5) in order to influence a broad spectrum of biological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	107-113
28367448-4	2017	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protein coupled receptors (S1P1-5) in order to influence a broad spectrum of biological processes.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28367448-4	2017	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protein coupled receptors (S1P1-5) in order to influence a broad spectrum of biological processes.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	107-113
27696512-1	2017	The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P) pathway is involved in multiple biological processes, including carcinogenesis.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
27696512-7	2017	S1P levels and expression of SphK1, SphK2, and S1P receptors (S1PR1/S1PR3) were significantly elevated in DEN-treated mice.	Diethylnitrosamine	106-109	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
27696512-7	2017	S1P levels and expression of SphK1, SphK2, and S1P receptors (S1PR1/S1PR3) were significantly elevated in DEN-treated mice.	Diethylnitrosamine	106-109	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
27696512-7	2017	S1P levels and expression of SphK1, SphK2, and S1P receptors (S1PR1/S1PR3) were significantly elevated in DEN-treated mice.	Diethylnitrosamine	106-109	sphingosine-1-phosphate receptor 1	Mus musculus	62-67
28038379-0	2017	High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.	sphingosine 1-phosphate	42-65	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
28038379-5	2017	S1P induced expression of the inhibitor of apoptosis protein (IAP) family proteins cIAP1, cIAP2 and survivin, but only the inhibitor of survivin expression YM155 and not the cIAP1/2 blocker GDC0152 reversed the inhibitory effect of S1P on apoptosis.	GDC-0152	190-197	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
28082452-6	2017	T-cell egress from lymph nodes was found to be a critical initial step for the onset of hypertension as fingolimod, a S1P-receptor agonist sequestering lymphocytes in the lymph nodes and inducing lymphopenia, blunted BP responses to AngII.	Fingolimod Hydrochloride	104-114	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
28035084-1	2017	Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, S1P1-5.	sphingosine 1-phosphate	21-44	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
28035084-1	2017	Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, S1P1-5.	sphingosine 1-phosphate	21-44	sphingosine-1-phosphate receptor 1	Mus musculus	226-232
28035084-4	2017	Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field.	Fingolimod Hydrochloride	32-42	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
28035084-4	2017	Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field.	Fingolimod Hydrochloride	44-50	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
27671228-2	2017	Emerging evidence shows that FTY720 protects against neural injury via modulation of the sphingosine-1-phosphate 1 receptor (S1PR1).	Fingolimod Hydrochloride	29-35	sphingosine-1-phosphate receptor 1	Mus musculus	125-130
27671228-2	2017	Emerging evidence shows that FTY720 protects against neural injury via modulation of the sphingosine-1-phosphate 1 receptor (S1PR1).	sphingosine 1-phosphate	89-112	sphingosine-1-phosphate receptor 1	Mus musculus	125-130
27671228-6	2017	An S1PR1-selective antagonist, W146, blocked the neuroprotective effects of FTY720.	W146	31-35	sphingosine-1-phosphate receptor 1	Mus musculus	3-8
27671228-6	2017	An S1PR1-selective antagonist, W146, blocked the neuroprotective effects of FTY720.	Fingolimod Hydrochloride	76-82	sphingosine-1-phosphate receptor 1	Mus musculus	3-8
30740601-2	2017	Thymic egress requires signals mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that serves as the ligand for a family of G protein-coupled receptors (S1P1-5) expressed on many cell types, including T cells.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	163-169
27696512-12	2017	Data obtained suggest a contribution of the SphK/S1P system and related signaling pathways to the protective effects of melatonin in hepatocarcinogenesis.	Melatonin	120-129	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
27683081-2	2016	Sphingosine 1-phosphate (S1P) regulates multiple cellular processes potentially involved in the pathogenesis of sepsis, including antigen presentation, lymphocyte egress, and maintenance of vascular integrity.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27612439-1	2016	Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that also plays crucial roles in bone regeneration.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
28018969-6	2016	Reciprocally, enhanced plasma levels of HDL-S1P or administration of SEW2871, a pharmacological agonist specific for S1P1 enhanced regeneration of metabolically functional vasculature and alleviated fibrosis in mouse chronic injury and cholestasis models.	SEW2871	69-76	sphingosine-1-phosphate receptor 1	Mus musculus	117-121
27883090-1	2016	The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons.	sphingosine 1-phosphate	20-43	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
27827329-9	2016	RESULTS: In vitro functional assays showed that LASW1238 is a selective agonist of the S1P1 receptor.	lasw1238	48-56	sphingosine-1-phosphate receptor 1	Mus musculus	87-91
27827329-13	2016	CONCLUSIONS: The selective S1P1 agonist LASW1238 reduces infarct volume after ischemia/reperfusion in mice, but only when lymphopenia is sustained for at least 24 hours.	lasw1238	40-48	sphingosine-1-phosphate receptor 1	Mus musculus	27-31
27883090-1	2016	The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons.	Sphingolipids	78-91	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
27883090-2	2016	We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium.	Calcium	119-126	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
27713021-3	2016	In this study we investigated whether disodium cromoglycate (DSCG), administered as a preventative treatment as in human therapy, could affect S1P effects on airways.	Cromolyn Sodium	38-59	sphingosine-1-phosphate receptor 1	Mus musculus	143-146
27829417-1	2016	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5.	Phospholipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
27829417-1	2016	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5.	Phospholipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
27829417-1	2016	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5.	Phospholipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	132-139
27713021-3	2016	In this study we investigated whether disodium cromoglycate (DSCG), administered as a preventative treatment as in human therapy, could affect S1P effects on airways.	Cromolyn Sodium	61-65	sphingosine-1-phosphate receptor 1	Mus musculus	143-146
27713021-4	2016	BALB/c mice, treated with DSCG, received subcutaneous administration of S1P.	Cromolyn Sodium	26-30	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
27713021-6	2016	DSCG inhibited S1P-induced airway hyper-reactivity as well as pulmonary inflammation.	Cromolyn Sodium	0-4	sphingosine-1-phosphate receptor 1	Mus musculus	15-18
27713021-11	2016	In conclusion we have shown that DSCG inhibits S1P-induced asthma like features in the mouse.	Cromolyn Sodium	33-37	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
27486054-1	2016	In this study, we investigated the involvement of Wnt signaling in sphingosine-1-phosphate (S1P)-enhanced osteogenic differentiation of C3H10T1/2 pluripotent stem cells.	sphingosine 1-phosphate	67-90	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
27417539-2	2016	Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunteers at 5,260 m altitude on day 1 and continue increasing to 16 days with concurrently elevated erythrocyte sphingonisne kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.	Oxygen	316-322	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
27343196-0	2016	Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&amp;2 signaling axis in lung endothelium.	Reactive Oxygen Species	41-44	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
27343196-0	2016	Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&amp;2 signaling axis in lung endothelium.	Reactive Oxygen Species	41-44	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
27343196-0	2016	Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&amp;2 signaling axis in lung endothelium.	Adenosine Monophosphate	112-115	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
27343196-0	2016	Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&amp;2 signaling axis in lung endothelium.	Adenosine Monophosphate	112-115	sphingosine-1-phosphate receptor 1	Mus musculus	107-111
27343196-4	2016	Sphingosine-1-phosphate (S1P) signaling is known to be involved in hyperoxia-mediated ROS generation; however, the mechanism(s) of S1P-induced NADPH oxidase activation is unclear.	Reactive Oxygen Species	86-89	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27343196-4	2016	Sphingosine-1-phosphate (S1P) signaling is known to be involved in hyperoxia-mediated ROS generation; however, the mechanism(s) of S1P-induced NADPH oxidase activation is unclear.	Reactive Oxygen Species	86-89	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
27343196-5	2016	Here, we investigated various steps in the S1P signaling pathway mediating ROS production in response to hyperoxia in lung endothelium.	Reactive Oxygen Species	75-78	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
27343196-6	2016	Of the two closely related sphingosine kinases (SphKs)1 and 2, which synthesize S1P from sphingosine, only Sphk1(-/-) mice conferred protection against hyperoxia-induced lung injury.	Sphingosine	27-38	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
27343196-8	2016	Hyperoxia stimulated S1P accumulation in human lung microvascular endothelial cells (HLMVECs), and downregulation of S1P transporter spinster homolog 2 (Spns2) or S1P receptors S1P1&amp;2, but not S1P3, using specific siRNA attenuated hyperoxia-induced p47(phox) translocation to cell periphery and ROS generation in HLMVECs.	Adenosine Monophosphate	182-185	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
27343196-8	2016	Hyperoxia stimulated S1P accumulation in human lung microvascular endothelial cells (HLMVECs), and downregulation of S1P transporter spinster homolog 2 (Spns2) or S1P receptors S1P1&amp;2, but not S1P3, using specific siRNA attenuated hyperoxia-induced p47(phox) translocation to cell periphery and ROS generation in HLMVECs.	Adenosine Monophosphate	182-185	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
27343196-8	2016	Hyperoxia stimulated S1P accumulation in human lung microvascular endothelial cells (HLMVECs), and downregulation of S1P transporter spinster homolog 2 (Spns2) or S1P receptors S1P1&amp;2, but not S1P3, using specific siRNA attenuated hyperoxia-induced p47(phox) translocation to cell periphery and ROS generation in HLMVECs.	Reactive Oxygen Species	299-302	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
27343196-8	2016	Hyperoxia stimulated S1P accumulation in human lung microvascular endothelial cells (HLMVECs), and downregulation of S1P transporter spinster homolog 2 (Spns2) or S1P receptors S1P1&amp;2, but not S1P3, using specific siRNA attenuated hyperoxia-induced p47(phox) translocation to cell periphery and ROS generation in HLMVECs.	Reactive Oxygen Species	299-302	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
27343196-9	2016	These results suggest a role for Spns2 and S1P1&amp;2 in hyperoxia-mediated ROS generation.	Adenosine Monophosphate	48-51	sphingosine-1-phosphate receptor 1	Mus musculus	43-47
27343196-9	2016	These results suggest a role for Spns2 and S1P1&amp;2 in hyperoxia-mediated ROS generation.	Reactive Oxygen Species	76-79	sphingosine-1-phosphate receptor 1	Mus musculus	43-47
27343196-11	2016	Our data indicate a novel role for Spns2 and S1P1&amp;2 in the activation of p47(phox) and production of ROS involved in hyperoxia-mediated lung injury in neonatal and adult mice.	Reactive Oxygen Species	105-108	sphingosine-1-phosphate receptor 1	Mus musculus	45-49
27429358-9	2016	KEY RESULTS: FTY-720 promoted the proliferation of embryonic hippocampal NSCs probably via the activation of ERK signalling, Gi/o proteins and S1P1 receptors.	Fingolimod Hydrochloride	13-20	sphingosine-1-phosphate receptor 1	Mus musculus	143-147
27280499-2	2016	Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding potency measured; four had high potency and selectivity for S1P1 (S1P1 IC50 &lt; 10 nM, &gt;100-fold selectivity for S1P1 over S1P2 and S1P3).	Fluorine	9-17	sphingosine-1-phosphate receptor 1	Mus musculus	158-162
27280499-2	2016	Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding potency measured; four had high potency and selectivity for S1P1 (S1P1 IC50 &lt; 10 nM, &gt;100-fold selectivity for S1P1 over S1P2 and S1P3).	Fluorine	9-17	sphingosine-1-phosphate receptor 1	Mus musculus	164-168
27280499-2	2016	Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding potency measured; four had high potency and selectivity for S1P1 (S1P1 IC50 &lt; 10 nM, &gt;100-fold selectivity for S1P1 over S1P2 and S1P3).	Fluorine	9-17	sphingosine-1-phosphate receptor 1	Mus musculus	164-168
27417539-2	2016	Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunteers at 5,260 m altitude on day 1 and continue increasing to 16 days with concurrently elevated erythrocyte sphingonisne kinase 1 (Sphk1) activity and haemoglobin (Hb) oxygen (O2) release capacity.	Oxygen	324-326	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
27417539-3	2016	Mouse genetic studies show that elevated erythrocyte Sphk1-induced S1P protects against tissue hypoxia by inducing O2 release.	Oxygen	115-117	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
27417539-4	2016	Mechanistically, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the release of membrane-bound glycolytic enzymes to the cytosol, induces glycolysis and thus the production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific glycolytic intermediate, which facilitates O2 release.	2,3-Diphosphoglycerate	220-243	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
27417539-4	2016	Mechanistically, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the release of membrane-bound glycolytic enzymes to the cytosol, induces glycolysis and thus the production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific glycolytic intermediate, which facilitates O2 release.	2,3-Diphosphoglycerate	245-252	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
27417539-4	2016	Mechanistically, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the release of membrane-bound glycolytic enzymes to the cytosol, induces glycolysis and thus the production of 2,3-bisphosphoglycerate (2,3-BPG), an erythrocyte-specific glycolytic intermediate, which facilitates O2 release.	Oxygen	322-324	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
27417539-5	2016	Altogether, we reveal S1P as an intracellular hypoxia-responsive biolipid promoting erythrocyte glycolysis, O2 delivery and thus new therapeutic opportunities to counteract tissue hypoxia.	Oxygen	108-110	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
26534925-6	2016	Furthermore, appropriate morphogenesis of the kidney vasculature, including glomerular capillary development, arterial mural cell coating, and lymphatic vessel development, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1 in these progenitors.	sphingosine 1-phosphate	182-205	sphingosine-1-phosphate receptor 1	Mus musculus	207-210
26534925-6	2016	Furthermore, appropriate morphogenesis of the kidney vasculature, including glomerular capillary development, arterial mural cell coating, and lymphatic vessel development, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1 in these progenitors.	sphingosine 1-phosphate	182-205	sphingosine-1-phosphate receptor 1	Mus musculus	248-262
27059959-1	2016	Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that regulates basic cell functions through metabolic and signaling pathways.	Sphingolipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27699272-5	2016	Long-term treatment with FTY720 induced significant lymphopenia and suppressed Th17 response in the peripheral immune system via downregulating STAT3 phosphorylation in both WT and S1PR1(S5A) mice.	Fingolimod Hydrochloride	25-31	sphingosine-1-phosphate receptor 1	Mus musculus	181-186
27283020-1	2016	BACKGROUND: The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions.	Lysophospholipids	16-33	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
27221351-7	2016	Finally, the activation of the remaining PPARgamma in Pparg(C/-) mice by pioglitazone increased S1P1 levels, reduced the Th17 population in the spleen, and ameliorated splenomegaly.	Pioglitazone	73-85	sphingosine-1-phosphate receptor 1	Mus musculus	96-100
26956418-1	2016	Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ~50% reduced plasma S1P levels.	sphingosine 1-phosphate	35-58	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
26956418-6	2016	Reconstitution of plasma ApoM/S1P or treatment with an S1P1 receptor agonist (SEW2871) rapidly reversed the vascular leakage to a level similar to that in WT mice, suggesting that it is caused by decreased plasma levels of S1P and reduced S1P1 stimulation.	SEW2871	78-85	sphingosine-1-phosphate receptor 1	Mus musculus	55-59
26956418-6	2016	Reconstitution of plasma ApoM/S1P or treatment with an S1P1 receptor agonist (SEW2871) rapidly reversed the vascular leakage to a level similar to that in WT mice, suggesting that it is caused by decreased plasma levels of S1P and reduced S1P1 stimulation.	SEW2871	78-85	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
26956418-6	2016	Reconstitution of plasma ApoM/S1P or treatment with an S1P1 receptor agonist (SEW2871) rapidly reversed the vascular leakage to a level similar to that in WT mice, suggesting that it is caused by decreased plasma levels of S1P and reduced S1P1 stimulation.	SEW2871	78-85	sphingosine-1-phosphate receptor 1	Mus musculus	239-243
27194029-2	2016	Sphingosine-1-phosphate (S1P), produced by sphingosine kinases (SphKs), is a bioactive lipid mediator that regulates processes important for cancer progression.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27207969-3	2016	METHODS AND RESULTS: Cardiomyocyte-restricted deletion of S1P1 in mice (S1P1 (alpha) (MHCC) (re)) resulted in progressive cardiomyopathy, compromised response to dobutamine, and premature death.	Dobutamine	162-172	sphingosine-1-phosphate receptor 1	Mus musculus	58-62
27207969-8	2016	In addition, S1P1 mediated the inhibitory effect of exogenous sphingosine-1-phosphate on beta-adrenergic-induced cardiomyocyte contractility by inhibiting the adenylate cyclase.	sphingosine 1-phosphate	62-85	sphingosine-1-phosphate receptor 1	Mus musculus	13-17
27207969-10	2016	CONCLUSIONS: Tonic S1P1 signaling by endogenous sphingosine-1-phosphate contributes to intracellular Ca(2+) homeostasis by maintaining basal NHE-1 activity and controls simultaneously myofibril Ca(2+) sensitivity through its inhibitory effect on adenylate cyclase.	sphingosine 1-phosphate	48-71	sphingosine-1-phosphate receptor 1	Mus musculus	19-23
26943364-1	2016	Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic beta-cells.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27158676-2	2016	Here, we show that endothelium-derived sphingolipids, particularly sphingosine-1-phosphate (S1P), protect the heart from inflammation, fibrosis, and dysfunction following pressure overload and that Nogo-B regulates this paracrine process.	Sphingolipids	39-52	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
26822263-1	2016	OBJECTIVE: A key mediator of vascular EC barrier integrity, S1P, is derived from phosphorylation of sphingosine by the SK-1 and SK-2.	Sphingosine	100-111	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
26286732-2	2016	Sphingosine 1-phosphate (S1P) is a sphingolipid and the natural ligand for five G protein-coupled receptors (S1P1, S1P2, S1P3, S1P4, and S1P5), and S1PR agonists reduce kidney ischemia-reperfusion injury (IRI) in mice.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	109-119
26884614-1	2016	Extracellular lysophosphatidate and sphingosine 1-phosphate (S1P) are important bioactive lipids, which signal through G-protein-coupled receptors to stimulate cell growth and survival.	sphingosine 1-phosphate	36-59	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
26884614-9	2016	However, administering 100 mg/kg/day doxycycline to mice decreased plasma concentrations of lysophosphatidate and S1P.	Doxycycline	37-48	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
26578687-7	2016	Treatment of cardiomyocytes with CTRP1 also resulted in the increased production of cAMP, which was blocked by suppression of S1P signaling.	Cyclic AMP	84-88	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
26762268-8	2016	Mechanistic in vitro and ex vivo studies revealed that 5 min of S1P treatment induced phosphorylation of the gap junction protein Connexin43 (Cx43) on Serine368 (S368), which was mediated by S1P2 and S1P3, but not by S1P1, receptors in cardiomyocytes.	serine368	151-160	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
26762268-8	2016	Mechanistic in vitro and ex vivo studies revealed that 5 min of S1P treatment induced phosphorylation of the gap junction protein Connexin43 (Cx43) on Serine368 (S368), which was mediated by S1P2 and S1P3, but not by S1P1, receptors in cardiomyocytes.	serine368	151-160	sphingosine-1-phosphate receptor 1	Mus musculus	217-221
26578687-10	2016	These data indicate that CTRP1 protects against myocardial ischemic injury by reducing apoptosis and inflammatory response through activation of the S1P/cAMP signaling pathways in cardiomyocytes, suggesting that CTRP1 plays a crucial role in the pathogenesis of ischemic heart disease.	Cyclic AMP	153-157	sphingosine-1-phosphate receptor 1	Mus musculus	149-152
26719367-4	2016	Cytoplasmic FTY720-P is an agonist for 4 of the 5 sphingosine-1-phosphate (S1P) receptors (S1P1, 3-5) and can also act as a functional antagonist of S1P1, whereas FTY720-P generated in the nucleus inhibits histone deacetylases (HDACs), leading to increased histone acetylation.	FTY 720P	12-20	sphingosine-1-phosphate receptor 1	Mus musculus	91-95
26921668-3	2016	The sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P) signaling pathway regulates oligodendroglia differentiation and function, and is known to be altered in hypoxia.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
26719367-4	2016	Cytoplasmic FTY720-P is an agonist for 4 of the 5 sphingosine-1-phosphate (S1P) receptors (S1P1, 3-5) and can also act as a functional antagonist of S1P1, whereas FTY720-P generated in the nucleus inhibits histone deacetylases (HDACs), leading to increased histone acetylation.	FTY 720P	12-20	sphingosine-1-phosphate receptor 1	Mus musculus	149-153
26445217-6	2016	KEY RESULTS: In cultures of HepG2 cells, resveratrol (1-10 muM) increased intracellular apoM and S1P.	Resveratrol	41-52	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
26856814-0	2016	The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.	siponimod	34-43	sphingosine-1-phosphate receptor 1	Mus musculus	9-14
26856814-1	2016	BACKGROUND: BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5.	siponimod	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	91-96
26856814-1	2016	BACKGROUND: BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5.	siponimod	20-29	sphingosine-1-phosphate receptor 1	Mus musculus	91-96
25900155-1	2016	BACKGROUND AND OBJECTIVE: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, which is generated by activation of sphingosine kinase (SK) 1 and/or 2 in most mammalian cells with various stimuli, including the oral pathogen Aggregatibacter actinomycetemcomitans.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
25900155-1	2016	BACKGROUND AND OBJECTIVE: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, which is generated by activation of sphingosine kinase (SK) 1 and/or 2 in most mammalian cells with various stimuli, including the oral pathogen Aggregatibacter actinomycetemcomitans.	Sphingolipids	71-83	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
26615875-4	2016	Enforced overexpression of SphK1 or treatment with sphingosine 1-phosphate (S1P) markedly enhanced hepatic lipid accumulation.	sphingosine 1-phosphate	51-74	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
26589326-4	2016	In MI-operated mice, inhibition of S1P production by using PF543 (the SphK1 inhibitor) ameliorated cardiac remodeling and dysfunction.	PF-543	59-64	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
26589326-8	2016	Administration of FTY720, a functional S1PR1 antagonist, obviously blocked cardiac SphK1/S1P/S1PR1 signaling, ameliorated chronic cardiac inflammation, and then improved cardiac remodeling and dysfunction in vivo post-MI.	Fingolimod Hydrochloride	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	39-44
26589326-8	2016	Administration of FTY720, a functional S1PR1 antagonist, obviously blocked cardiac SphK1/S1P/S1PR1 signaling, ameliorated chronic cardiac inflammation, and then improved cardiac remodeling and dysfunction in vivo post-MI.	Fingolimod Hydrochloride	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
26589326-8	2016	Administration of FTY720, a functional S1PR1 antagonist, obviously blocked cardiac SphK1/S1P/S1PR1 signaling, ameliorated chronic cardiac inflammation, and then improved cardiac remodeling and dysfunction in vivo post-MI.	Fingolimod Hydrochloride	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	93-98
26445217-10	2016	When wild-type mice were fed a resveratrol-containing chow (0.3% w/w) for 2 weeks, both the plasma and hepatic apoM and S1P levels were increased.	Resveratrol	31-42	sphingosine-1-phosphate receptor 1	Mus musculus	120-123
26445217-13	2016	The present findings suggest that resveratrol has novel effects on the metabolic kinetics of S1P, a multi-functional bioactive phospholipid.	Resveratrol	34-45	sphingosine-1-phosphate receptor 1	Mus musculus	93-96
26445217-13	2016	The present findings suggest that resveratrol has novel effects on the metabolic kinetics of S1P, a multi-functional bioactive phospholipid.	Phospholipids	127-139	sphingosine-1-phosphate receptor 1	Mus musculus	93-96
27271904-2	2016	The chemoattractant-chemoattractant receptor axes that predominately govern the trafficking of lymphocytes into, and out of, LNs are CCL19/CCR7 and sphingosine 1-phosphate (S1P)/S1P receptor 1 (S1PR1), respectively.	sphingosine 1-phosphate	148-171	sphingosine-1-phosphate receptor 1	Mus musculus	173-176
26884643-3	2016	Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and disease.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26884643-3	2016	Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and disease.	Sphingolipids	67-79	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26414003-2	2016	Sphingosine 1-phosphate (S1P) is a signaling sphingolipid, derived from sphingosine by the action of sphingosine kinase (SK).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26414003-2	2016	Sphingosine 1-phosphate (S1P) is a signaling sphingolipid, derived from sphingosine by the action of sphingosine kinase (SK).	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26414003-2	2016	Sphingosine 1-phosphate (S1P) is a signaling sphingolipid, derived from sphingosine by the action of sphingosine kinase (SK).	Sphingosine	72-83	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26254847-8	2016	Mechanistically, hepatocyte exosomes directly fuse with target hepatocytes and transfer neutral ceramidase and sphingosine kinase 2 (SK2) causing increased synthesis of sphingosine-1-phosphate (S1P) within target hepatocytes.	sphingosine 1-phosphate	169-192	sphingosine-1-phosphate receptor 1	Mus musculus	194-197
27271904-2	2016	The chemoattractant-chemoattractant receptor axes that predominately govern the trafficking of lymphocytes into, and out of, LNs are CCL19/CCR7 and sphingosine 1-phosphate (S1P)/S1P receptor 1 (S1PR1), respectively.	sphingosine 1-phosphate	148-171	sphingosine-1-phosphate receptor 1	Mus musculus	194-199
26482537-3	2015	We previously showed that overload of saturated fatty acids, such as that which occurs with metabolic syndrome, induced sphingosine kinase 1 (SphK1), an enzyme that generates sphingosine-1-phosphate (S1P).	Fatty Acids	38-59	sphingosine-1-phosphate receptor 1	Mus musculus	200-203
26324848-1	2015	Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid metabolite that regulates numerous processes important for immune responses.	Sphingolipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26286721-2	2015	Sphingosine-1-phosphate (S1P) signalling plays a critical role in pulmonary fibrosis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26371341-2	2015	Recently, we postulated a major role for bioactive lipids such as sphingosine-1 phosphate (S1P) in mobilization of BMSPCs into the peripheral blood (PB).	sphingosine 1-phosphate	66-89	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
26795749-2	2015	It is thought that fingolimod modulates the immune response by activating sphingosine-1 phosphate receptor type 1 (S1P1) on lymphocytes following its in vivo phosphorylation.	Fingolimod Hydrochloride	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	74-113
26795749-2	2015	It is thought that fingolimod modulates the immune response by activating sphingosine-1 phosphate receptor type 1 (S1P1) on lymphocytes following its in vivo phosphorylation.	Fingolimod Hydrochloride	19-29	sphingosine-1-phosphate receptor 1	Mus musculus	115-119
26371341-3	2015	We hypothesized that elevating S1P levels after AMI could augment BMSPC mobilization and enhance cardiac recovery after AMI.	bmspc	66-71	sphingosine-1-phosphate receptor 1	Mus musculus	31-34
26371341-4	2015	After AMI, elevating bioactive lipid levels was achieved by treating mice with the S1P lyase inhibitor tetrahydroxybutylimidazole (THI) for 3 days (starting at day 4 after AMI) to differentiate between stem cell mobilization and the known effects of S1P on myocardial ischemic pre- and postconditioning.	tetrahydroxybutylimidazole	103-129	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
26371341-4	2015	After AMI, elevating bioactive lipid levels was achieved by treating mice with the S1P lyase inhibitor tetrahydroxybutylimidazole (THI) for 3 days (starting at day 4 after AMI) to differentiate between stem cell mobilization and the known effects of S1P on myocardial ischemic pre- and postconditioning.	tetrahydroxybutylimidazole	103-129	sphingosine-1-phosphate receptor 1	Mus musculus	250-253
26371341-4	2015	After AMI, elevating bioactive lipid levels was achieved by treating mice with the S1P lyase inhibitor tetrahydroxybutylimidazole (THI) for 3 days (starting at day 4 after AMI) to differentiate between stem cell mobilization and the known effects of S1P on myocardial ischemic pre- and postconditioning.	2-acetyl-4(5)-tetrahydroxybutylimidazole	131-134	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
26371341-4	2015	After AMI, elevating bioactive lipid levels was achieved by treating mice with the S1P lyase inhibitor tetrahydroxybutylimidazole (THI) for 3 days (starting at day 4 after AMI) to differentiate between stem cell mobilization and the known effects of S1P on myocardial ischemic pre- and postconditioning.	2-acetyl-4(5)-tetrahydroxybutylimidazole	131-134	sphingosine-1-phosphate receptor 1	Mus musculus	250-253
26371341-8	2015	We observed a greater than twofold increase in plasma S1P and circulating BMSPCs after THI treatment.	2-acetyl-4(5)-tetrahydroxybutylimidazole	87-90	sphingosine-1-phosphate receptor 1	Mus musculus	54-57
25988659-2	2015	The lipid mediator sphingosine-1-phosphate (S1P) has been reported to play a role in the mechanotransduction process of blood vessels and also in the dynamic control of bone mineral homeostasis.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
26474409-1	2015	Dyshomeostasis of both ceramides and sphingosine-1-phosphate (S1P) in the brain has been implicated in aging-associated neurodegenerative disorders in humans.	sphingosine 1-phosphate	37-60	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
26446219-4	2015	Sphingosine 1-phosphate (S1P) is a bioactive lipid that interacts with cell-surface receptors to exert different cellular responses.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25988659-7	2015	We found that decreased endogenous S1P levels significantly suppressed the OFF-induced intracellular calcium response.	Calcium	101-108	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	84-100	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	102-106	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
25988659-8	2015	Addition of extracellular S1P to MLO-Y4 cells enhanced the synthesis and release of prostaglandin E2 (PGE2) under static cells and amplified OFF-induced PGE2 release.	Dinoprostone	153-157	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
25988668-5	2015	Increased levels of CXCR2, CXCR4, S1P/S1PR1, PlGF and PDGF-BB were identified in the serum or primary tumour tissues of tumour-bearing mice treated by paclitaxel.	Paclitaxel	151-161	sphingosine-1-phosphate receptor 1	Mus musculus	34-37
26243740-1	2015	Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25988668-5	2015	Increased levels of CXCR2, CXCR4, S1P/S1PR1, PlGF and PDGF-BB were identified in the serum or primary tumour tissues of tumour-bearing mice treated by paclitaxel.	Paclitaxel	151-161	sphingosine-1-phosphate receptor 1	Mus musculus	38-43
26299919-4	2015	While SDF-1 is the only chemokine that chemoattracts HSPCs, other chemoattractants for these cells have recently been described, including the bioactive phosphosphingolipid sphingosine-1-phosphate (S1P).	phosphosphingolipid	153-172	sphingosine-1-phosphate receptor 1	Mus musculus	198-201
26268607-0	2015	HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.	sphingosine 1-phosphate	10-33	sphingosine-1-phosphate receptor 1	Mus musculus	93-97
26268607-4	2015	The chaperones ApoM(+)HDL (HDL) or albumin bind to sphingosine 1-phosphate (S1P) in the circulation; therefore, we tested the effects of S1P bound to each chaperone on S1P1 signaling in cultured human umbilical vein endothelial cells (HUVECs).	sphingosine 1-phosphate	51-74	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
27011900-5	2015	Sphingosine-1-phosphate (S1P) is a bioactive lipid produced through degradation of endogenous and dietary mammalian sphingolipids containing the long chain base sphingosine.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27011900-5	2015	Sphingosine-1-phosphate (S1P) is a bioactive lipid produced through degradation of endogenous and dietary mammalian sphingolipids containing the long chain base sphingosine.	Sphingolipids	116-129	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27011900-5	2015	Sphingosine-1-phosphate (S1P) is a bioactive lipid produced through degradation of endogenous and dietary mammalian sphingolipids containing the long chain base sphingosine.	Sphingosine	161-172	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
27011900-12	2015	Further, we propose the hypothesis that dietary sphingolipids may promote or prevent CAC depending on their ability to be converted to S1P.	Sphingolipids	48-61	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
25985799-1	2015	Sphingosine 1-phosphate (S1P) is a bioactive lipid that can function both extracellularly and intracellularly to mediate a variety of cellular processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25985799-7	2015	S1P-induced in vitro tube formation was significantly attenuated in the presence of the PPARgamma antagonist GW9662, and in vivo application of GW9662 also reduced vascular development in Matrigel plugs.	2-chloro-5-nitrobenzanilide	109-115	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
25985799-7	2015	S1P-induced in vitro tube formation was significantly attenuated in the presence of the PPARgamma antagonist GW9662, and in vivo application of GW9662 also reduced vascular development in Matrigel plugs.	2-chloro-5-nitrobenzanilide	144-150	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
26324256-1	2015	Sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) system has been implicated in the pathological process of liver injury.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	ptx	13-16	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-30	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	CAY10444	143-152	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
26324256-8	2015	Furthermore, PTX and LY-294002 (PI3K inhibitor) prevented S1PR2/3-mediated BMM migration, and Rac1 activation by S1P was inhibited by JTE-013, CAY-10444 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	156-164	sphingosine-1-phosphate receptor 1	Mus musculus	58-61
26324256-10	2015	In conclusion, S1P/S1PR2/3 system mediates BMM motility by PTX-PI3K-Rac1 signaling pathway, which provides new compelling information on the role of S1P/S1PR in liver injury and opens new perspectives for the pharmacological treatment of hepatic fibrosis.	ptx	59-62	sphingosine-1-phosphate receptor 1	Mus musculus	15-18
26324256-10	2015	In conclusion, S1P/S1PR2/3 system mediates BMM motility by PTX-PI3K-Rac1 signaling pathway, which provides new compelling information on the role of S1P/S1PR in liver injury and opens new perspectives for the pharmacological treatment of hepatic fibrosis.	ptx	59-62	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
25719311-6	2015	In addition, in vivo studies showed that dexamethasone downregulated S1P1 expression in glomeruli isolated from mice treated with dexamethasone (10 mg/kg body weight).	Dexamethasone	41-54	sphingosine-1-phosphate receptor 1	Mus musculus	69-73
26283908-2	2015	The bioactive lipid sphingosine 1-phosphate (S1P) and its receptors have recently been shown to modulate nociceptive signaling at the level of peripheral nociceptors and central neurons.	sphingosine 1-phosphate	20-43	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
25930666-4	2015	Here, we investigated whether the mitogenic sphingolipid, sphingosine-1-phosphate (S1P), is involved in intimal hyperplasia elicited by W6/32.	Sphingolipids	44-56	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
25930666-4	2015	Here, we investigated whether the mitogenic sphingolipid, sphingosine-1-phosphate (S1P), is involved in intimal hyperplasia elicited by W6/32.	sphingosine 1-phosphate	58-81	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
25930666-6	2015	hmSMC migration and DNA synthesis elicited by W6/32 were inhibited by the sphingosine kinase-1 (SK1) inhibitor dimethylsphingosine, the anti-S1P antibody Sphingomab and the S1PR1/R3 inhibitor VPC23019.	hmsmc	0-5	sphingosine-1-phosphate receptor 1	Mus musculus	141-144
25930666-6	2015	hmSMC migration and DNA synthesis elicited by W6/32 were inhibited by the sphingosine kinase-1 (SK1) inhibitor dimethylsphingosine, the anti-S1P antibody Sphingomab and the S1PR1/R3 inhibitor VPC23019.	hmsmc	0-5	sphingosine-1-phosphate receptor 1	Mus musculus	173-178
25930666-6	2015	hmSMC migration and DNA synthesis elicited by W6/32 were inhibited by the sphingosine kinase-1 (SK1) inhibitor dimethylsphingosine, the anti-S1P antibody Sphingomab and the S1PR1/R3 inhibitor VPC23019.	VPC23019	192-200	sphingosine-1-phosphate receptor 1	Mus musculus	173-178
25911610-3	2015	Here, we show that sphingosine 1-phosphate (S1P) levels are not only increased in palmitate-stimulated pancreatic beta-cells but also regulate beta-cell homeostasis in a divergent manner.	Palmitates	82-91	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
26129975-2	2015	Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P).	Sphingosine	62-73	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
26129975-2	2015	Sphingosine kinases (Sphk) 1 and 2 catalyze the conversion of sphingosine to the bioactive metabolite sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	102-125	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
26129975-8	2015	We revealed that S1P controls platelet aggregation via the sphingosine 1-phosphate receptor 1 through modulation of protease-activated receptor 4-peptide and adenosine diphosphate-induced platelet activation.	Adenosine Diphosphate	158-179	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
26129975-8	2015	We revealed that S1P controls platelet aggregation via the sphingosine 1-phosphate receptor 1 through modulation of protease-activated receptor 4-peptide and adenosine diphosphate-induced platelet activation.	Adenosine Diphosphate	158-179	sphingosine-1-phosphate receptor 1	Mus musculus	59-93
26082434-0	2015	Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.	Sphingolipids	15-27	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
26082434-4	2015	We found that the lysophospholipid sphingosine 1-phosphate (S1P), generated by sphingosine kinase 2 (SK2), bound hTERT at the nuclear periphery in human and mouse fibroblasts.	Lysophospholipids	18-34	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
26082434-4	2015	We found that the lysophospholipid sphingosine 1-phosphate (S1P), generated by sphingosine kinase 2 (SK2), bound hTERT at the nuclear periphery in human and mouse fibroblasts.	sphingosine 1-phosphate	35-58	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
25720064-2	2015	FTY720 has been shown to reduce the nociceptive behavior in the paclitaxel model for chemotherapy-induced neuropathic pain through downregulation of S1P receptor 1 (S1P1) in microglia of the spinal cord.	Paclitaxel	64-74	sphingosine-1-phosphate receptor 1	Mus musculus	149-163
25720064-2	2015	FTY720 has been shown to reduce the nociceptive behavior in the paclitaxel model for chemotherapy-induced neuropathic pain through downregulation of S1P receptor 1 (S1P1) in microglia of the spinal cord.	Paclitaxel	64-74	sphingosine-1-phosphate receptor 1	Mus musculus	165-169
25719311-6	2015	In addition, in vivo studies showed that dexamethasone downregulated S1P1 expression in glomeruli isolated from mice treated with dexamethasone (10 mg/kg body weight).	Dexamethasone	130-143	sphingosine-1-phosphate receptor 1	Mus musculus	69-73
24965069-2	2015	The S1P-induced current is mainly carried by anions, because the reversal potential of the current was shifted by replacement of extracellular Cl(-) by glutamate(-) but not when extracellular Na(+) was substituted by Tris(+).	Glutamic Acid	152-161	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
25908861-1	2015	The sphingolipids, sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC), can induce or inhibit cellular migration.	Sphingolipids	4-17	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
24965069-2	2015	The S1P-induced current is mainly carried by anions, because the reversal potential of the current was shifted by replacement of extracellular Cl(-) by glutamate(-) but not when extracellular Na(+) was substituted by Tris(+).	Tromethamine	217-221	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
24965069-5	2015	As cytochalasin D diminished the action of S1P, we conclude that the actin cytoskeleton is involved in the stimulation of VRAC.	vrac	122-126	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
24965069-6	2015	S1P and hypotonic extracellular solution induced secretion of ATP from the macrophages, which in both cases was blocked in a similar way by typical VRAC blockers.	Adenosine Triphosphate	62-65	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
24965069-7	2015	We suppose that the S1P-induced ATP secretion in macrophages via activation of VRAC constitutes a functional link between sphingolipid and purinergic signaling in essential processes such as inflammation and migration of leukocytes as well as phagocytosis and the killing of intracellular bacteria.	Adenosine Triphosphate	32-35	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
24965069-7	2015	We suppose that the S1P-induced ATP secretion in macrophages via activation of VRAC constitutes a functional link between sphingolipid and purinergic signaling in essential processes such as inflammation and migration of leukocytes as well as phagocytosis and the killing of intracellular bacteria.	vrac	79-83	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
24965069-7	2015	We suppose that the S1P-induced ATP secretion in macrophages via activation of VRAC constitutes a functional link between sphingolipid and purinergic signaling in essential processes such as inflammation and migration of leukocytes as well as phagocytosis and the killing of intracellular bacteria.	Sphingolipids	122-134	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
25776899-3	2015	Here, we explore the efficacy of SEW2871, a selective S1PR1 agonist, in the prevention of acute allograft rejection in a murine cardiac transplantation model.	SEW2871	33-40	sphingosine-1-phosphate receptor 1	Mus musculus	54-59
25954148-1	2015	At the site of injury activated platelets release various mediators, one of which is sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	85-108	sphingosine-1-phosphate receptor 1	Mus musculus	110-113
25801013-1	2015	BACKGROUND: Sphingosine 1-phosphate (S1P) is a lysosphingolipid associated with high-density lipoproteins (HDL) that contributes to their anti-atherogenic potential.	Sphingolipids	47-63	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
25637806-10	2015	It was also observed that levels of ROS were significantly decreased in the MPP(+)-treated cells in the presence of exogenous S1P.	Reactive Oxygen Species	36-39	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
25637806-5	2015	Since mitochondrial dysfunction has been described to be the major pathological event in PD, the present study focused on the role of Sphk2/S1P signaling in promoting mitochondrial functions in the MPTP-induced mouse model of PD and in 1-methyl-4 phenylpyridinium (MPP(+))-treated MN9D cells.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	198-202	sphingosine-1-phosphate receptor 1	Mus musculus	140-143
25831442-1	2015	Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive lipid mediator that regulates many processes in vertebrate development, physiology, and pathology.	Sphingolipids	9-22	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
25637806-5	2015	Since mitochondrial dysfunction has been described to be the major pathological event in PD, the present study focused on the role of Sphk2/S1P signaling in promoting mitochondrial functions in the MPTP-induced mouse model of PD and in 1-methyl-4 phenylpyridinium (MPP(+))-treated MN9D cells.	1-Methyl-4-phenylpyridinium	236-263	sphingosine-1-phosphate receptor 1	Mus musculus	140-143
25512083-1	2015	BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid produced by mast cells (MCs) on cross-linking of their high-affinity receptors for IgE by antigen that can amplify MC responses by binding to its S1P receptors.	Sphingolipids	57-69	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
25832730-6	2015	In a counter-regulatory manner, S1P1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P1(-/-) mice.	Cyclic AMP	46-50	sphingosine-1-phosphate receptor 1	Mus musculus	32-36
25145931-0	2015	Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.	Cisplatin	79-88	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
25145931-1	2015	Sphingosine 1-phosphate (S1P), the natural sphingolipid ligand for a family of five G protein- coupled receptors (S1P1-S1P5Rs), regulates cell survival and lymphocyte circulation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	114-118
25145931-1	2015	Sphingosine 1-phosphate (S1P), the natural sphingolipid ligand for a family of five G protein- coupled receptors (S1P1-S1P5Rs), regulates cell survival and lymphocyte circulation.	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	114-118
25145931-5	2015	Cisplatin induced more renal injury in PT-S1P1-null mice than in controls.	Cisplatin	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	42-46
25145931-7	2015	Furthermore, the increase in proinflammatory cytokine (CXCL1, MCP-1, TNF-alpha, and IL-6) expression and infiltration of neutrophils and macrophages induced by cisplatin treatment was attenuated by FTY720 in control mice but not in PT-S1P1-null mice.	Cisplatin	160-169	sphingosine-1-phosphate receptor 1	Mus musculus	235-239
25680461-8	2015	On the other hand, exogenously-added S1P activated Akt and reduced Dex-induced osteoblast damages.	Dexamethasone	67-70	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
25627684-0	2015	Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.	sphingosine 1-phosphate	70-93	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
25627684-1	2015	Apolipoprotein M (apoM), a plasma sphingosine 1-phosphate (S1P) carrier, associates with plasma HDL via its uncleaved signal peptide.	sphingosine 1-phosphate	34-57	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
25627684-7	2015	Pharmacologic inhibition of ceramide synthesis increased cellular sphingosine and S1P but not medium S1P in both apoM(WT) and apoM(Q22A) hepatocytes.	Ceramides	28-36	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
25445169-8	2015	During adipogenic differentiation, S1P suppressed the cAMP accumulation in a Gi-protein-dependent manner.	Cyclic AMP	54-58	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
25445169-11	2015	These findings suggest that S1P suppresses cAMP accumulation, leading to inhibition of C/EBPbeta expression, thereby resulting in decreased adipogenic differentiation of C3H10T1/2 cells.	Cyclic AMP	43-47	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
25680461-9	2015	LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
25680461-9	2015	LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex.	MK 2206	13-20	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
25680461-9	2015	LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex.	Dexamethasone	119-122	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
25505264-7	2015	The present findings clarify the novel roles of the LDL receptor and apoE in the clearance of S1P, a multifunctional bioactive phospholipid.	Phospholipids	127-139	sphingosine-1-phosphate receptor 1	Mus musculus	94-97
25432063-1	2015	Sphingosine 1-phosphate (S1P) is involved in multiple pathological processes, including fibrogenesis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25505264-1	2015	Sphingosine 1-phosphate (S1P) is a vasoactive lipid mediator that is speculated to be involved in various aspects of atherosclerosis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25446881-2	2015	Levels of sphingosine-1-phosphate (S1P), a naturally occurring bioactive lipid, are elevated in bronchoalveolar fluids and lung tissues from IPF patients and animal models of pulmonary fibrosis.	sphingosine 1-phosphate	10-33	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
25505264-3	2015	In the previous study with human subjects, however, LDL cholesterol or apoB, but not HDL cholesterol or apoA-I, had a significant positive correlation with the plasma S1P level, suggesting that the metabolic pathway for LDL might have some roles in the metabolism of S1P.	Cholesterol	56-67	sphingosine-1-phosphate receptor 1	Mus musculus	167-170
25446881-9	2015	Over-expression of S1PL attenuated bleomycin-induced TGF-beta secretion and S1P mediated differentiation of human lung fibroblasts through regulation of autophagy.	Bleomycin	35-44	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
25446881-3	2015	However, the in vivo contribution of S1P, regulated by its synthesis catalyzed by Sphingosine kinases (SphKs) 1 &amp; 2 and catabolism by S1P phosphatases and S1P lyase (S1PL), in the pathogenesis of pulmonary fibrosis is not well defined.	Adenosine Monophosphate	113-116	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
25431213-0	2014	Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Galphai/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	45-49
25347472-9	2014	In mice with chemical-induced CAC, oral administration of plant-type sphingolipids called sphingadienes increased colonic SPL levels and reduced S1P levels, STAT3 signaling, cytokine levels, and tumorigenesis, indicating that SPL prevents transformation and carcinogenesis.	Sphingolipids	69-82	sphingosine-1-phosphate receptor 1	Mus musculus	145-148
25347472-9	2014	In mice with chemical-induced CAC, oral administration of plant-type sphingolipids called sphingadienes increased colonic SPL levels and reduced S1P levels, STAT3 signaling, cytokine levels, and tumorigenesis, indicating that SPL prevents transformation and carcinogenesis.	sphingadienes	90-103	sphingosine-1-phosphate receptor 1	Mus musculus	145-148
25347472-10	2014	Together, our results suggest that dietary sphingolipids can augment or prevent colon cancer, depending upon whether they are metabolized to S1P or promote S1P metabolism through the actions of SPL.	Sphingolipids	43-56	sphingosine-1-phosphate receptor 1	Mus musculus	141-144
25347472-10	2014	Together, our results suggest that dietary sphingolipids can augment or prevent colon cancer, depending upon whether they are metabolized to S1P or promote S1P metabolism through the actions of SPL.	Sphingolipids	43-56	sphingosine-1-phosphate receptor 1	Mus musculus	156-159
25948069-3	2015	The aim of this study was to explore the effect of SEW2871, a S1P1-selective agonist, on caerulein-induced AP in mice.	SEW2871	51-58	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
25948069-3	2015	The aim of this study was to explore the effect of SEW2871, a S1P1-selective agonist, on caerulein-induced AP in mice.	Ceruletide	89-98	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
25176316-0	2015	Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	87-90
25176316-3	2015	The angiogenic mechanism of oxLDL is partly understood, but the role of the angiogenic sphingolipid, sphingosine 1-phosphate (S1P), in this process is not known.	Sphingolipids	87-99	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
25176316-3	2015	The angiogenic mechanism of oxLDL is partly understood, but the role of the angiogenic sphingolipid, sphingosine 1-phosphate (S1P), in this process is not known.	sphingosine 1-phosphate	101-124	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
25385827-1	2015	Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25385827-2	2015	S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in sphingolipid catabolism.	Sphingolipids	99-111	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
25385827-2	2015	S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in sphingolipid catabolism.	Sphingolipids	99-111	sphingosine-1-phosphate receptor 1	Mus musculus	50-53
25347472-2	2014	Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in colon cancer.	Sphingolipids	78-90	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25347472-2	2014	Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in colon cancer.	Sphingolipids	78-90	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
25431213-0	2014	Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Galphai/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.	Capsaicin	96-105	sphingosine-1-phosphate receptor 1	Mus musculus	45-49
25431213-4	2014	In this study, the S1P mediated signaling pathway required for sensitization of TRPV1 channels was explored.The capsaicin induced peak inward current (ICAPS) of sensory neurons was significantly increased after S1P stimulation within minutes after application.	Capsaicin	112-121	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
25431213-4	2014	In this study, the S1P mediated signaling pathway required for sensitization of TRPV1 channels was explored.The capsaicin induced peak inward current (ICAPS) of sensory neurons was significantly increased after S1P stimulation within minutes after application.	Capsaicin	112-121	sphingosine-1-phosphate receptor 1	Mus musculus	211-214
25431213-5	2014	The potentiation of ICAPS resulted from activation of Galphai through G-protein coupled receptors for S1P.	icaps	20-25	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
25431213-7	2014	The S1P1 receptor agonist SEW2871 resulted in activation of the same signaling pathway and potentiation of ICAPS.	SEW2871	26-33	sphingosine-1-phosphate receptor 1	Mus musculus	4-8
25431213-7	2014	The S1P1 receptor agonist SEW2871 resulted in activation of the same signaling pathway and potentiation of ICAPS.	icaps	107-112	sphingosine-1-phosphate receptor 1	Mus musculus	4-8
25431213-8	2014	Furthermore, the mitogen-activated protein kinase p38 was phosphorylated after S1P stimulation and inhibition of p38 signaling by SB203580 prevented the S1P-induced ICAPS potentiation.	SB 203580	130-138	sphingosine-1-phosphate receptor 1	Mus musculus	153-156
25431213-8	2014	Furthermore, the mitogen-activated protein kinase p38 was phosphorylated after S1P stimulation and inhibition of p38 signaling by SB203580 prevented the S1P-induced ICAPS potentiation.	icaps	165-170	sphingosine-1-phosphate receptor 1	Mus musculus	153-156
25431213-9	2014	The current data suggest that S1P sensitized ICAPS through G-protein coupled S1P1 receptor activation of Galphai-PI3K-PKC-p38 signaling pathway in sensory neurons.	icaps	45-50	sphingosine-1-phosphate receptor 1	Mus musculus	30-33
25431213-9	2014	The current data suggest that S1P sensitized ICAPS through G-protein coupled S1P1 receptor activation of Galphai-PI3K-PKC-p38 signaling pathway in sensory neurons.	icaps	45-50	sphingosine-1-phosphate receptor 1	Mus musculus	77-81
25231106-1	2014	Sphingosine 1-phosphate (S1P) is a powerful regulator of platelet formation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25180446-9	2014	Overexpression of SphK1 and stimulation with S1P potentially via ligation of S1PR2 promoted PASMC proliferation in vitro, whereas SphK1 deficiency inhibited PASMC proliferation.	pasmc	92-97	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
25180446-10	2014	CONCLUSIONS: The SphK1/S1P axis is a novel pathway in PAH that promotes PASMC proliferation, a major contributor to pulmonary vascular remodeling.	pasmc	72-77	sphingosine-1-phosphate receptor 1	Mus musculus	23-26
25158625-11	2014	Resting platelets contained a second pool of constitutively releasable S1P that was more rapidly labeled by exogenously added sphingosine.	Sphingosine	126-137	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
25422763-12	2014	CONCLUSIONS: In STZ mice, the levels of S1P and ApoM in the plasma, liver, and kidneys were increased.	Streptozocin	16-19	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
25250575-8	2014	Together, these findings demonstrate that rbc are essential for embryogenesis by supplying the lysophospholipid S1P, which regulates embryonic vascular development via its receptors.	Lysophospholipids	95-111	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
25422763-6	2014	RESULTS: In STZ mice, both the plasma S1P and ApoM levels were higher than those in control mice.	Streptozocin	12-15	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
25422763-11	2014	Regarding the kidney, the renal levels of S1P and ApoM were increased in STZ mice, and insulin treatment partially restored this increment.	Streptozocin	73-76	sphingosine-1-phosphate receptor 1	Mus musculus	42-45
25356849-2	2014	S1P is a biologically active lysophospholipid with multiple roles in signalling.	Lysophospholipids	29-45	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
24768038-1	2014	Sphingosine 1-phosphate (S1P) plays important roles in cell proliferation, differentiation or survival mainly through its surface G-protein-coupled receptors S1P1-5.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25330249-4	2014	Herein, we show that sphingosine-1-phosphate (S1P), a potent mediator of T cell chemotaxis, plays a role in the exit of immature double-negative thymocytes in experimental Chagas disease.	sphingosine 1-phosphate	21-44	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
24768038-1	2014	Sphingosine 1-phosphate (S1P) plays important roles in cell proliferation, differentiation or survival mainly through its surface G-protein-coupled receptors S1P1-5.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	158-164
25309325-4	2014	More recently, simple sphingolipids such ceramide, sphingosine and sphingosine 1-phosphate (S1P) were discovered to signal in response to many extracellular stimuli.	Sphingolipids	22-35	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
24863045-3	2014	In this study, we have developed and characterized two novel oxazolo-oxazole derivatives of FTY720, ST-968 and the oxy analog ST-1071, which require no preceding activating phosphorylation, and proved to be active in intact cells and triggered S1P1 and S1P3, but not S1P2, receptor internalization as a result of receptor activation.	oxazolo-oxazole	61-76	sphingosine-1-phosphate receptor 1	Mus musculus	244-257
25309325-6	2014	The immunomodulator fingolimod is the prodrug of an S1P receptor agonist.	Fingolimod Hydrochloride	20-30	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
25309325-11	2014	Indeed, a seminal study showed that the protective effect of fingolimod in experimental autoimmune encephalitis (EAE), a murine MS model, is lost in mice lacking the S1P1 receptor on astrocytes, arguing for a specific role of astrocytic S1P signaling in MS.	Fingolimod Hydrochloride	61-71	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
25198418-1	2014	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes, including proliferation, migration, and angiogenesis, through interaction with a family of five G protein-coupled receptors (S1P1-5).	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25198418-1	2014	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes, including proliferation, migration, and angiogenesis, through interaction with a family of five G protein-coupled receptors (S1P1-5).	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	240-246
25075016-4	2014	Sphingosine-1-phosphate (S1P) and its receptor-1 (S1PR1) play an important role in lymphocyte migration.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	50-55
25043204-8	2014	Importantly, fingolimod blocked the 2 activation events evoked in astrocytes by either S1P or inflammatory cytokines, resulting in inhibition of astrocyte-mediated neurodegeneration.	Fingolimod Hydrochloride	13-23	sphingosine-1-phosphate receptor 1	Mus musculus	87-90
24768784-1	2014	BACKGROUND: Preanalytical standardization is required for a reliable quantification of the signaling molecules sphingosine-1-phosphate (S1P), sphinganine-1-phosphate (SA1P) and sphingosine (SPH).	sphingosine 1-phosphate	111-134	sphingosine-1-phosphate receptor 1	Mus musculus	136-139
24768784-1	2014	BACKGROUND: Preanalytical standardization is required for a reliable quantification of the signaling molecules sphingosine-1-phosphate (S1P), sphinganine-1-phosphate (SA1P) and sphingosine (SPH).	Sphingosine	111-122	sphingosine-1-phosphate receptor 1	Mus musculus	136-139
25000441-1	2014	AIM: Sphingosine-1-phosphate (S1P) is a cardioprotective agent.	sphingosine 1-phosphate	5-28	sphingosine-1-phosphate receptor 1	Mus musculus	30-33
24768784-6	2014	RESULTS: Storing EDTA whole blood &gt;60min after blood withdrawal at room temperature resulted in an increase in S1P and SPH concentrations of &gt;=25%.	Edetic Acid	17-21	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
24768784-8	2014	Repeated freeze-thaw cycles of EDTA plasma resulted in increased S1P and SPH levels.	Edetic Acid	31-35	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
24768784-9	2014	Concentrations in human EDTA plasma were between 55.5 and 145.2ng/mL for S1P and between 8.9 and 35.3ng/mL for SA1P.	Edetic Acid	24-28	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
24768784-10	2014	Concentrations of S1P were 36% lower and 96% higher in EDTA-plasma from SK1- and SK2-deficient mice, respectively, compared to the wild type.	Edetic Acid	55-59	sphingosine-1-phosphate receptor 1	Mus musculus	18-21
24740542-3	2014	Sphingosine 1-phosphate receptor 1 (S1PR1) is a GPCR for circulating lysophospholipid S1P that is highly expressed in blood and lymphatic vessels.	Lysophospholipids	69-85	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
24740542-3	2014	Sphingosine 1-phosphate receptor 1 (S1PR1) is a GPCR for circulating lysophospholipid S1P that is highly expressed in blood and lymphatic vessels.	Lysophospholipids	69-85	sphingosine-1-phosphate receptor 1	Mus musculus	36-41
24448174-3	2014	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid and regulates T-lymphocyte trafficking.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
24837436-1	2014	Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
25006445-2	2014	Cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel expressed in both epithelial and endothelial cells, regulates the organization of tight junctions between epithelial cells and has also been implicated in the transport of sphingosine-1 phosphate (S1P), a vascular barrier-enhancing sphingolipid.	sphingosine 1-phosphate	249-272	sphingosine-1-phosphate receptor 1	Mus musculus	274-277
25006445-9	2014	Loss of CFTR function, especially concomitant to CS exposure, might promote lung inflammation by increasing endothelial cell permeability, which could be ameliorated by S1P.	Cesium	49-51	sphingosine-1-phosphate receptor 1	Mus musculus	169-172
24960577-4	2014	Recent work showed that the bioactive lipid sphingosine-1-phosphate (S1P) plays crucial roles in the activation, proliferation, and differentiation of muscle satellite cells.	sphingosine 1-phosphate	44-67	sphingosine-1-phosphate receptor 1	Mus musculus	69-72
25010202-9	2014	Blockade of the egress of cells from the spleen was performed by administration of the Sphingosine-1-phosphate receptor 1 (S1P1) agonist CYM-5442 10 h after L/IM.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	137-145	sphingosine-1-phosphate receptor 1	Mus musculus	87-121
25010202-9	2014	Blockade of the egress of cells from the spleen was performed by administration of the Sphingosine-1-phosphate receptor 1 (S1P1) agonist CYM-5442 10 h after L/IM.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	137-145	sphingosine-1-phosphate receptor 1	Mus musculus	123-127
24611843-1	2014	SEW2871, a selective sphingosine-1-phosphate type 1 receptor (S1P1) agonist, has been shown to be effective in protecting kidneys against ischaemia-reperfusion injury by reducing CD4(+) T cell infiltration in mice.	SEW2871	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	21-66
24911000-2	2014	The phosphorylated version of Fingolimod (pFTY720), an oral therapy for multiple sclerosis (MS), induces S1PR1 internalisation in T cells, subsequent insensitivity to S1P gradients and sequestering of these cells within lymphoid organs, thus limiting immune response.	Fingolimod Hydrochloride	30-40	sphingosine-1-phosphate receptor 1	Mus musculus	105-110
24343820-1	2014	Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus.	sp	131-133	sphingosine-1-phosphate receptor 1	Mus musculus	34-48
24343820-1	2014	Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an important role in the egress of mature CD4 or CD8 single-positive (SP) thymocytes from the thymus.	sp	131-133	sphingosine-1-phosphate receptor 1	Mus musculus	50-54
24343820-2	2014	Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymic medulla.	Fingolimod Hydrochloride	0-24	sphingosine-1-phosphate receptor 1	Mus musculus	38-42
24343820-2	2014	Fingolimod hydrochloride (FTY720), an S1P1 functional antagonist, induced significant accumulation of CD62L(high)CD69(low) mature SP thymocytes in the thymic medulla.	Fingolimod Hydrochloride	26-32	sphingosine-1-phosphate receptor 1	Mus musculus	38-42
24343820-5	2014	At 6h after THI administration, S1P1-expressing thymocytes reduced partially as if to form clusters and hardly existed in the proximity of CD31-expressing blood vessels in the thymic medulla, suggesting S1P lyase expression in the cells constructing thymic medullary PVS.	2-acetyl-4(5)-tetrahydroxybutylimidazole	12-15	sphingosine-1-phosphate receptor 1	Mus musculus	32-36
24335440-0	2014	FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury.	Organophosphonates	7-22	sphingosine-1-phosphate receptor 1	Mus musculus	33-67
24434636-5	2014	By using specific S1P receptor agonists (SEW2871, FTY720-P) and antagonist (JTE013) we identified an important role for S1P receptor 1 in the modulation of the cytokine profile.	JTE 013	76-82	sphingosine-1-phosphate receptor 1	Mus musculus	120-134
25151732-2	2014	HTRF-IP1 test indicated that Syl948-P, the active form of Syl948 in vitro, has strong activity against S1P1 (EC50: 83 +/- 16 nmol x L(-1)), but its effect on S1P3 was very weak (EC50: 1 026 +/- 90 nmol x L(-1)).	Isopenicillin N	5-8	sphingosine-1-phosphate receptor 1	Mus musculus	103-107
24573171-13	2014	CONCLUSIONS: Topical 0.5% S1P1 agonist is as effective as 1% CsA, and both can effectively prolong the survival of corneal allografts in mice.	Cyclosporine	61-64	sphingosine-1-phosphate receptor 1	Mus musculus	26-30
24667638-1	2014	Activation of the GPCR sphingosine-1-phosphate receptor 1 (S1P1) by sphingosine-1-phosphate (S1P) regulates key physiological processes.	sphingosine 1-phosphate	23-46	sphingosine-1-phosphate receptor 1	Mus musculus	59-63
24714781-2	2014	Here we show that Memo null mouse embryonic fibroblasts (MEFs) are impaired in PDGF-induced migration and this is due to a defect in sphingosine-1-phosphate (S1P) signaling.	sphingosine 1-phosphate	133-156	sphingosine-1-phosphate receptor 1	Mus musculus	158-161
24714781-3	2014	S1P is a bioactive phospholipid produced in response to multiple stimuli, which regulates many cellular processes.	Phospholipids	19-31	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
24131465-6	2014	L-NAME (N(G)-nitro-L-arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect.	NG-Nitroarginine Methyl Ester	0-6	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
24131465-6	2014	L-NAME (N(G)-nitro-L-arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect.	NG-Nitroarginine Methyl Ester	8-42	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
24131465-6	2014	L-NAME (N(G)-nitro-L-arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect.	Wortmannin	48-58	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
24131465-7	2014	Either ENMD1068, a PAR-2 antagonist, or gabexate, a serine protease inhibitor, significantly inhibited S1P-induced vasorelaxation.	Gabexate	40-48	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
24335440-11	2014	FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphate receptor 1 protein expression in contrast to greater than 50% reduction after incubation with sphingosine 1-phosphate, FTY720, or other sphingosine 1-phosphate receptor 1 agonists.	Fingolimod Hydrochloride	0-6	sphingosine-1-phosphate receptor 1	Mus musculus	45-79
24335440-11	2014	FTY720 (S)-phosphonate maintains endothelial sphingosine 1-phosphate receptor 1 protein expression in contrast to greater than 50% reduction after incubation with sphingosine 1-phosphate, FTY720, or other sphingosine 1-phosphate receptor 1 agonists.	Organophosphonates	7-22	sphingosine-1-phosphate receptor 1	Mus musculus	45-79
24335440-13	2014	Intraperitoneal administration of FTY720 (S)-phosphonate every other day for 1 week in normal or bleomycin-injured mice maintains significantly higher lung sphingosine 1-phosphate receptor 1 expression compared with FTY720.	Fingolimod Hydrochloride	34-40	sphingosine-1-phosphate receptor 1	Mus musculus	156-190
24335440-13	2014	Intraperitoneal administration of FTY720 (S)-phosphonate every other day for 1 week in normal or bleomycin-injured mice maintains significantly higher lung sphingosine 1-phosphate receptor 1 expression compared with FTY720.	Organophosphonates	41-56	sphingosine-1-phosphate receptor 1	Mus musculus	156-190
24335440-13	2014	Intraperitoneal administration of FTY720 (S)-phosphonate every other day for 1 week in normal or bleomycin-injured mice maintains significantly higher lung sphingosine 1-phosphate receptor 1 expression compared with FTY720.	Bleomycin	97-106	sphingosine-1-phosphate receptor 1	Mus musculus	156-190
24335440-15	2014	CONCLUSION: FTY720 (S)-phosphonate is a promising barrier-promoting agent that effectively maintains sphingosine 1-phosphate receptor 1 levels and improves outcomes in the bleomycin model of acute lung injury.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	101-135
24335440-15	2014	CONCLUSION: FTY720 (S)-phosphonate is a promising barrier-promoting agent that effectively maintains sphingosine 1-phosphate receptor 1 levels and improves outcomes in the bleomycin model of acute lung injury.	Organophosphonates	19-34	sphingosine-1-phosphate receptor 1	Mus musculus	101-135
24516133-1	2014	Sphingosine 1-phosphate (S1P) plays a role in lymphocyte egress from lymphoid organs.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
24145189-7	2014	In addition, S1P induced VEGF expression and VEGFR2 kinase inhibitor (SU1498) blocked the S1P-induced cellular proliferation.	SU 1498	70-76	sphingosine-1-phosphate receptor 1	Mus musculus	90-93
23910624-10	2014	S1P1 alone increased CD4+ T (p &lt; 0.01) and Treg cells (p &lt; 0.01; n = 5) in the cervical and mesenteric lymph nodes compared with the controls and S1P1 + rapamycin (p &lt; 0.05; n = 5).	Sirolimus	159-168	sphingosine-1-phosphate receptor 1	Mus musculus	0-4
24028747-3	2014	Sphingosine-1-phosphate (S1P) controls the migration of osteoclast precursor cells (OCPs) between the blood and bone marrow, in part via S1P receptors (S1PR1 and S1PR2) expressed on the surface of OCPs.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	152-157
24158769-1	2014	Sphingosine-1-phosphate (S1P) is an amphiphilic signaling molecule, which is enriched in functional high density lipoprotein (HDL) and shows arterial protection.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
24158769-6	2014	The results of the S1P transfer assay indicated that PLTP could facilitate S1P transport from erythrocytes to HDL at 37  C in D-Hanks buffer.	d-hanks buffer	126-140	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
24158769-6	2014	The results of the S1P transfer assay indicated that PLTP could facilitate S1P transport from erythrocytes to HDL at 37  C in D-Hanks buffer.	d-hanks buffer	126-140	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
24190514-1	2014	Sphingosine-1-phosphate (S1P), a biologically active pleiotropic lipid, is involved in several physiological processes especially in the area of vascular biology and immunology encompassing cell survival, angiogenesis, vascular tone, immune response etc.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
24190514-8	2014	Overwhelming anti-oxidative and anti-inflammatory benefits of S1P preconditioning could also be captured in the present study, as indicated by improved redox homeostasis, reduced oxidative damage, balanced anti/pro-inflammatory cytokine profiles and temporal regulation of nitric oxide secretion and intra-cellular calcium release.	Nitric Oxide	273-285	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
24190514-8	2014	Overwhelming anti-oxidative and anti-inflammatory benefits of S1P preconditioning could also be captured in the present study, as indicated by improved redox homeostasis, reduced oxidative damage, balanced anti/pro-inflammatory cytokine profiles and temporal regulation of nitric oxide secretion and intra-cellular calcium release.	Calcium	315-322	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
24292566-3	2014	Besides ceramides, sphingosine 1-phosphate (S1P) has been identified as a major bioactive lipid mediator.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
24292566-7	2014	RESULTS: Palmitate induced an impressive formation of extra- and intracellular S1P in rat and human hepatocytes.	Palmitates	9-18	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
24292566-10	2014	The inhibitory effect of S1P was abolished in the presence of the S1P2 receptor antagonist JTE-013 both in vitro and in vivo.	JTE 013	91-98	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
24292566-11	2014	In agreement with this, the immunomodulator FTY720-phosphate, which binds to all S1P receptors except S1P2, was not able to inhibit insulin signalling.	FTY 720P	44-60	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
24292566-12	2014	CONCLUSIONS/INTERPRETATION: These data indicate that palmitate is metabolised by hepatocytes to S1P, which acts via stimulation of the S1P2 receptor to impair insulin signalling.	Palmitates	53-62	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
24318881-1	2014	Apolipoprotein M (apoM), a lipocalin family member, preferentially associates with plasma HDL and binds plasma sphingosine 1-phosphate (S1P), a signaling molecule active in immune homeostasis and endothelial barrier function.	sphingosine 1-phosphate	111-134	sphingosine-1-phosphate receptor 1	Mus musculus	136-139
24394822-2	2014	Ceramide and sphingosine-1-phosphate (S1P) form the center of sphingolipid metabolism and determine proapoptotic and antiapoptotic balance.	sphingosine 1-phosphate	13-36	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
24394822-2	2014	Ceramide and sphingosine-1-phosphate (S1P) form the center of sphingolipid metabolism and determine proapoptotic and antiapoptotic balance.	Sphingolipids	62-74	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
24394822-7	2014	In a murine model of BPD, intervention with an S1P analog had a favorable effect on histologic abnormalities and ceramide levels.	Ceramides	113-121	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
24077965-2	2014	Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystrophic muscle degeneration.	2-acetyl-5-tetrahydroxybutyl imidazole	140-178	sphingosine-1-phosphate receptor 1	Mus musculus	189-192
24077965-3	2014	In the dystrophic mouse (mdx), upregulation of S1P by THI increases regeneration and muscle force.	2-acetyl-4(5)-tetrahydroxybutylimidazole	54-57	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
24077965-6	2014	Here we show that beneficial effects of THI treatment in mdx mice correlate with significantly increased nuclear S1P, decreased HDAC activity and increased acetylation of specific histone residues.	2-acetyl-4(5)-tetrahydroxybutylimidazole	40-43	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
24077965-9	2014	Accordingly, S1P levels and functional mitochondrial activity are increased after THI treatment of differentiating C2C12 cells.	2-acetyl-4(5)-tetrahydroxybutylimidazole	82-85	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
24077965-10	2014	S1P increases the capacity of the muscle cell to use fatty acids as an energy source, suggesting that THI treatment could be beneficial for the maintenance of energy metabolism in mdx muscles.	Fatty Acids	53-64	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
24077965-10	2014	S1P increases the capacity of the muscle cell to use fatty acids as an energy source, suggesting that THI treatment could be beneficial for the maintenance of energy metabolism in mdx muscles.	2-acetyl-4(5)-tetrahydroxybutylimidazole	102-105	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
24145189-9	2014	S1P and VEGF-induced phosphorylation of ERK and JNK were blocked by pretreatment with SU1498.	SU 1498	86-92	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
23861379-3	2013	We documented that osteoclasts secrete the mammalian integration 1 gene that is the homolog of Drosophila Wngless (Wnt) 10b, bone morphogenetic protein 6 (BMP6), and the chemokine sphingosin 1 phosphate (S1P) to promote mesenchymal cell mineralization in vitro.	sphingosin 1 phosphate	180-202	sphingosine-1-phosphate receptor 1	Mus musculus	204-207
24265321-1	2013	Studies in cell culture and mouse models of cancer have indicated that the soluble sphingolipid metabolite sphingosine 1-phosphate (S1P) promotes cancer cell proliferation, survival, invasiveness, and tumor angiogenesis.	Sphingolipids	83-95	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
24265321-4	2013	We demonstrate, for the first time, a systematic shift in sphingolipid metabolism favoring S1P over ceramide, which increases with increasing cancer grade.	Sphingolipids	58-70	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
23904439-4	2013	Accordingly, MCs of S1P lyase-deficient mice were mostly degranulated in the tissues and showed enhanced calcium levels, degranulation, and cytokine production in response to IgE/Ag in vitro.	Calcium	105-112	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
23904439-6	2013	However, when S1P levels were increased by pharmacologic inhibition of S1P lyase, the C57BL/6 mice showed increased histamine release into the circulation and anaphylactic responses similar to those in the 129/Sv mice.	Histamine	116-125	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
23904439-6	2013	However, when S1P levels were increased by pharmacologic inhibition of S1P lyase, the C57BL/6 mice showed increased histamine release into the circulation and anaphylactic responses similar to those in the 129/Sv mice.	Histamine	116-125	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
23904439-7	2013	Culturing of MCs in the presence of S1P enhanced their degranulation responses, and when the S1P-treated MCs were used to reconstitute MC-deficient (Kit(W-sh)) mice, they caused enhanced anaphylaxis.	Methylcholanthrene	13-15	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
23904439-9	2013	Our findings argue that dysregulation in the metabolism of S1P is a contributing factor in modulating MC responsiveness and the allergic response.	Methylcholanthrene	102-104	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
24358210-1	2013	The lipid mediator sphingosine 1-phosphate (S1P) regulates a wide range of cellular activities, including vascular maturation, angiogenesis, and immune-cell trafficking.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
24744854-1	2013	The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions.	Sphingolipids	10-22	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
25383272-6	2013	In contrast, pretreatment of (R)-3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a selective antagonist of S1P1, significantly augments AMD3100-induced KSL-HSPC mobilization into peripheral blood.	(r)-3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid	29-90	sphingosine-1-phosphate receptor 1	Mus musculus	125-129
25383272-6	2013	In contrast, pretreatment of (R)-3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a selective antagonist of S1P1, significantly augments AMD3100-induced KSL-HSPC mobilization into peripheral blood.	W146	92-96	sphingosine-1-phosphate receptor 1	Mus musculus	125-129
25383272-9	2013	Collectively, our data suggest that S1P/S1P1 signaling regulates the SDF-1/CXCR4-mediated retention of KSL-HSPCs in bone marrow microenvironment.	ksl	103-106	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
25383272-9	2013	Collectively, our data suggest that S1P/S1P1 signaling regulates the SDF-1/CXCR4-mediated retention of KSL-HSPCs in bone marrow microenvironment.	ksl	103-106	sphingosine-1-phosphate receptor 1	Mus musculus	40-44
24183308-9	2013	PLP is required for the breakdown of sphingosine 1-phosphate (S1P), a chemotactic lipid, by S1P lyase.	sphingosine 1-phosphate	37-60	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
24183308-9	2013	PLP is required for the breakdown of sphingosine 1-phosphate (S1P), a chemotactic lipid, by S1P lyase.	sphingosine 1-phosphate	37-60	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
23933064-7	2013	In vitro experiments using human lung microvascular endothelial cells showed that exogenous S1P stimulated intracellular reactive oxygen species (ROS) generation, whereas SphK1 siRNA, or inhibitor against SphK1, attenuated hyperoxia-induced S1P generation.	Reactive Oxygen Species	121-144	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
23933064-7	2013	In vitro experiments using human lung microvascular endothelial cells showed that exogenous S1P stimulated intracellular reactive oxygen species (ROS) generation, whereas SphK1 siRNA, or inhibitor against SphK1, attenuated hyperoxia-induced S1P generation.	Reactive Oxygen Species	146-149	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
23933064-8	2013	Knockdown of NOX2 and NOX4, using specific siRNA, reduced both basal and S1P-induced ROS formation.	Reactive Oxygen Species	85-88	sphingosine-1-phosphate receptor 1	Mus musculus	73-76
23933064-9	2013	These results suggest an important role for SphK1-mediated S1P signaling-regulated ROS in the development of hyperoxia-induced lung injury in a murine neonatal model of bronchopulmonary dysplasia.	Reactive Oxygen Species	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
24039766-3	2013	However, in obesity little is known about the plasma concentrations of sphinogsine-1-phosphate (S1P), the breakdown product of ceramide, which is an important signaling molecule in mammalian biology.	sphinogsine-1-phosphate	71-94	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
23892195-5	2013	Upregulation of tissue and circulatory S1P levels were achieved via inhibition of S1P lyase by 2-acetyl-5-tetrahydroxybutyl imidazole (THI).	2-acetyl-5-tetrahydroxybutyl imidazole	95-133	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
23892195-5	2013	Upregulation of tissue and circulatory S1P levels were achieved via inhibition of S1P lyase by 2-acetyl-5-tetrahydroxybutyl imidazole (THI).	2-acetyl-5-tetrahydroxybutyl imidazole	95-133	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
23892195-5	2013	Upregulation of tissue and circulatory S1P levels were achieved via inhibition of S1P lyase by 2-acetyl-5-tetrahydroxybutyl imidazole (THI).	2-acetyl-4(5)-tetrahydroxybutylimidazole	135-138	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
23892195-5	2013	Upregulation of tissue and circulatory S1P levels were achieved via inhibition of S1P lyase by 2-acetyl-5-tetrahydroxybutyl imidazole (THI).	2-acetyl-4(5)-tetrahydroxybutylimidazole	135-138	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
23892195-9	2013	Improved resuscitation and survival of THI-treated SphK1-KO mice were better correlated with cardiac dihydro-S1P (DHS1P) than S1P levels.	2-acetyl-4(5)-tetrahydroxybutylimidazole	39-42	sphingosine-1-phosphate receptor 1	Mus musculus	109-112
23892195-9	2013	Improved resuscitation and survival of THI-treated SphK1-KO mice were better correlated with cardiac dihydro-S1P (DHS1P) than S1P levels.	2-acetyl-4(5)-tetrahydroxybutylimidazole	39-42	sphingosine-1-phosphate receptor 1	Mus musculus	116-119
23892195-10	2013	The lack of SphK1 and the inhibition of S1P lyase by THI were accompanied by modulation in cardiac S1PR1 and S1PR2 expression and by selective changes in plasma N-palmitoyl- and N-behenoyl-ceramide levels.	2-acetyl-4(5)-tetrahydroxybutylimidazole	53-56	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
23892195-10	2013	The lack of SphK1 and the inhibition of S1P lyase by THI were accompanied by modulation in cardiac S1PR1 and S1PR2 expression and by selective changes in plasma N-palmitoyl- and N-behenoyl-ceramide levels.	Nitrogen	161-162	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
23892195-10	2013	The lack of SphK1 and the inhibition of S1P lyase by THI were accompanied by modulation in cardiac S1PR1 and S1PR2 expression and by selective changes in plasma N-palmitoyl- and N-behenoyl-ceramide levels.	palmitoyl-	163-173	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
23892195-10	2013	The lack of SphK1 and the inhibition of S1P lyase by THI were accompanied by modulation in cardiac S1PR1 and S1PR2 expression and by selective changes in plasma N-palmitoyl- and N-behenoyl-ceramide levels.	n-behenoyl-ceramide	178-197	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
24039766-3	2013	However, in obesity little is known about the plasma concentrations of sphinogsine-1-phosphate (S1P), the breakdown product of ceramide, which is an important signaling molecule in mammalian biology.	Ceramides	127-135	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
24039766-7	2013	Furthermore, in humans, plasma S1P positively correlated with total body fat percentage, body mass index (BMI), waist circumference, fasting insulin, HOMA-IR, HbA1c (%), total and LDL cholesterol.	Cholesterol	184-195	sphingosine-1-phosphate receptor 1	Mus musculus	31-34
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	130-171	sphingosine-1-phosphate receptor 1	Mus musculus	28-50
23845219-2	2013	Sphingosine kinases (SphKs) catalyze a key step in sphingomyelin metabolism that leads to the production of S1P.	Sphingomyelins	51-64	sphingosine-1-phosphate receptor 1	Mus musculus	108-111
23723371-3	2013	The effects of HDL on endothelial cells are mediated in part by HDL-associated sphingosine 1-phosphate (S1P), which binds to S1P1 receptors and promotes activation of endothelial NO synthase (eNOS) and the kinase Akt.	sphingosine 1-phosphate	79-102	sphingosine-1-phosphate receptor 1	Mus musculus	104-107
23723371-3	2013	The effects of HDL on endothelial cells are mediated in part by HDL-associated sphingosine 1-phosphate (S1P), which binds to S1P1 receptors and promotes activation of endothelial NO synthase (eNOS) and the kinase Akt.	sphingosine 1-phosphate	79-102	sphingosine-1-phosphate receptor 1	Mus musculus	125-129
23723371-9	2013	HDL-induced endothelial cell migration and Akt/eNOS phosphorylation were completely inhibited by the S1P1 antagonist W146 but not by the S1P3 antagonist CAY10444.	W146	117-121	sphingosine-1-phosphate receptor 1	Mus musculus	101-105
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	130-171	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	130-171	sphingosine-1-phosphate receptor 1	Mus musculus	182-185
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	173-176	sphingosine-1-phosphate receptor 1	Mus musculus	28-50
23731666-2	2013	Sphingolipid metabolites, including ceramide (Cer) and sphingosine-1-phosphate (S1P), are bioactive signaling molecules that regulate cell movement, differentiation, survival, and apoptosis, but their effects on preimplantation development of murine embryos are not well-characterized.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	173-176	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
23731666-4	2013	The blastocyst formation rate was decreased in the C2-Cer-treated group, compared with that in the control group and the group treated with 50 muM C2-Cer plus 25, 50, or 100 nM S1P (P &lt; 0.05), respectively.	N-acetylsphingosine	51-57	sphingosine-1-phosphate receptor 1	Mus musculus	177-180
23915702-2	2013	Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, has beneficial effects in acutely injured dystrophic muscles of mdx mice.	2-acetyl-4(5)-tetrahydroxybutylimidazole	173-176	sphingosine-1-phosphate receptor 1	Mus musculus	182-185
23915702-12	2013	CONCLUSIONS: These data show that S1P is beneficial for muscle regeneration and functional gain in dystrophic mice, and that THI, or other pharmacological agents that raise S1P levels systemically, may be developed into an effective treatment for improving muscle function and reducing the pathology of DMD.	2-acetyl-4(5)-tetrahydroxybutylimidazole	125-128	sphingosine-1-phosphate receptor 1	Mus musculus	173-176
23643308-1	2013	BACKGROUND: It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes.	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
23449739-4	2013	Sphingosine 1-phosphate (S1P) is a naturally occurring bioactive sphingolipid that acts extracellularly via its G protein-coupled S1P1-5 as well as intracellularly on various targets.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
23449739-4	2013	Sphingosine 1-phosphate (S1P) is a naturally occurring bioactive sphingolipid that acts extracellularly via its G protein-coupled S1P1-5 as well as intracellularly on various targets.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	130-136
23449739-4	2013	Sphingosine 1-phosphate (S1P) is a naturally occurring bioactive sphingolipid that acts extracellularly via its G protein-coupled S1P1-5 as well as intracellularly on various targets.	Sphingolipids	65-77	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
23449739-4	2013	Sphingosine 1-phosphate (S1P) is a naturally occurring bioactive sphingolipid that acts extracellularly via its G protein-coupled S1P1-5 as well as intracellularly on various targets.	Sphingolipids	65-77	sphingosine-1-phosphate receptor 1	Mus musculus	130-136
23449739-7	2013	In addition to S1P, S1P analogues such as 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol (FTY720), FTY720 phosphate, and FTY720 phosphonates offer therapeutic potential in murine models of lung injury.	2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol	42-92	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
23664237-1	2013	OBJECTIVES: Sphingosine 1-phosphate (S1P) is a vasoprotective lipid mediator that is mainly carried on HDL in the circulation and several anti-atherosclerotic properties of HDL is considered to be ascribed to S1P.	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
23664237-1	2013	OBJECTIVES: Sphingosine 1-phosphate (S1P) is a vasoprotective lipid mediator that is mainly carried on HDL in the circulation and several anti-atherosclerotic properties of HDL is considered to be ascribed to S1P.	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	209-212
23643308-1	2013	BACKGROUND: It has been indicated that the sphingolipid sphingosine-1-phosphate (S1P) restrains the ability of dendritic cells to migrate to lymph nodes.	sphingosine 1-phosphate	56-79	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
23643308-11	2013	Whereas topical administration of calcipotriol led to a low but significant increase of stratum granulosum, S1P and FTY720 lacked such an effect.	calcipotriene	34-46	sphingosine-1-phosphate receptor 1	Mus musculus	108-111
23466305-0	2013	Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
23466305-0	2013	Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis.	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
23466305-1	2013	BACKGROUND &amp; AIMS: Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) axis is involved in multiple biological processes, including liver fibrosis.	Adenosine Monophosphate	12-15	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
24619572-1	2013	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
23466305-1	2013	BACKGROUND &amp; AIMS: Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) axis is involved in multiple biological processes, including liver fibrosis.	Adenosine Monophosphate	12-15	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
23466305-1	2013	BACKGROUND &amp; AIMS: Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) axis is involved in multiple biological processes, including liver fibrosis.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
23466305-1	2013	BACKGROUND &amp; AIMS: Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) axis is involved in multiple biological processes, including liver fibrosis.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
24619572-1	2013	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
23392686-1	2013	The biolipid sphingosine-1-phosphate (S1P) is an essential modulator of innate immunity, cell migration, and wound healing.	biolipid	4-12	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
25002997-3	2013	Though the bioactive lipid sphingosine 1-phosphate (S1P) has been implicated in many anabolic processes in many cell types and tissues, including muscle, this work confirmed the therapeutic potential of assessing this pathway for DMD.	sphingosine 1-phosphate	27-50	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
23569273-4	2013	In this study, we found that active vitamin D reduced the expression of S1PR2, a chemorepulsive receptor for blood S1P, on circulating osteoclast precursor monocytes both in vitro and in vivo.	Vitamin D	36-45	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
23569273-5	2013	Calcitriol- or eldecalcitol-treated monocytoid RAW264.7 cells, which display osteoclast precursor-like properties, migrated readily to S1P.	Calcitriol	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
23569273-5	2013	Calcitriol- or eldecalcitol-treated monocytoid RAW264.7 cells, which display osteoclast precursor-like properties, migrated readily to S1P.	eldecalcitol	15-27	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
23569273-5	2013	Calcitriol- or eldecalcitol-treated monocytoid RAW264.7 cells, which display osteoclast precursor-like properties, migrated readily to S1P.	monocytoid	36-46	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
23301082-3	2013	Generation of S1P requires phosphorylation of sphingosine by SK, of which there are two isoforms.	Sphingosine	46-57	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
23230267-2	2013	ER stress also increases production of the proapoptotic lipid ceramide and its antiapoptotic metabolite, sphingosine-1-phosphate (S1P).	Ceramides	62-70	sphingosine-1-phosphate receptor 1	Mus musculus	130-133
23230267-4	2013	Cellular ceramide and S1P levels rose in parallel with CAMP levels following addition of either exogenous cell-permeating ceramide (C2Cer), which increases S1P production, or thapsigargin (an ER stressor), applied to cultured human skin keratinocytes or topically to mouse skin.	Ceramides	122-130	sphingosine-1-phosphate receptor 1	Mus musculus	156-159
23230267-4	2013	Cellular ceramide and S1P levels rose in parallel with CAMP levels following addition of either exogenous cell-permeating ceramide (C2Cer), which increases S1P production, or thapsigargin (an ER stressor), applied to cultured human skin keratinocytes or topically to mouse skin.	c2cer	132-137	sphingosine-1-phosphate receptor 1	Mus musculus	156-159
23230267-4	2013	Cellular ceramide and S1P levels rose in parallel with CAMP levels following addition of either exogenous cell-permeating ceramide (C2Cer), which increases S1P production, or thapsigargin (an ER stressor), applied to cultured human skin keratinocytes or topically to mouse skin.	Thapsigargin	175-187	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
23307289-3	2013	In this study, we are interested in the action of sphingosine 1-phosphate (S1P) on ICC.	sphingosine 1-phosphate	50-73	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
23307289-7	2013	However, JTE-013 (an S1P(2) antagonist) blocked the S1P-induced action.	JTE 013	9-16	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
23307289-7	2013	However, JTE-013 (an S1P(2) antagonist) blocked the S1P-induced action.	JTE 013	9-16	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
23307289-11	2013	External Ca(2+)-free solution or thapsigargin (a Ca(2+)-ATPase inhibitor of endoplasmic reticulum) suppressed action of S1P on ICC.	Thapsigargin	33-45	sphingosine-1-phosphate receptor 1	Mus musculus	120-123
23307289-12	2013	In recording of intracellular Ca(2+) ([Ca(2+)](i)) concentration using fluo-4/AM S1P increased intensity of spontaneous [Ca(2+)](i) oscillations in ICC.	Fluo 4	71-77	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
23073075-1	2013	Fingolimod (FTY720), a novel drug approved for the treatment of relapsing-remitting multiple sclerosis, activates different sphingosine-1-phosphate receptor (S1PR) subtypes.	Fingolimod Hydrochloride	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	124-147
23073075-1	2013	Fingolimod (FTY720), a novel drug approved for the treatment of relapsing-remitting multiple sclerosis, activates different sphingosine-1-phosphate receptor (S1PR) subtypes.	Fingolimod Hydrochloride	12-18	sphingosine-1-phosphate receptor 1	Mus musculus	124-147
23073075-6	2013	FTY720, FTY720-P, and S1P were all neuroprotective when applied 18-20 h prior to the NMDA pulse.	N-Methylaspartate	85-89	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
22750505-1	2013	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid whose actions are essential for many physiological processes including angiogenesis, lymphocyte trafficking and development.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	Carbon	116-122	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	Carbon	116-122	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	Carbon	116-122	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	(E)-2-hexadecenal	162-173	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	(E)-2-hexadecenal	162-173	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	(E)-2-hexadecenal	162-173	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	phosphorylethanolamine	178-200	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	phosphorylethanolamine	178-200	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22750505-6	2013	S1P is irreversibly catabolized by S1P lyase (SPL), a highly conserved enzyme that catalyzes the cleavage of S1P at carbon bond C(2-3), resulting in formation of hexadecenal and ethanolamine-phosphate.	phosphorylethanolamine	178-200	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22913344-9	2013	All of these inhibitors except VPC23019 and nifedipine significantly reduced the S1P-induced tonic contractions.	VPC23019	31-39	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
22913344-9	2013	All of these inhibitors except VPC23019 and nifedipine significantly reduced the S1P-induced tonic contractions.	Nifedipine	44-54	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
22913344-10	2013	S1P (5x10(-7)  M) also induced significant tonic contractions in the lymph vessels that had been superfused with high K(+)  Krebs-bicarbonate solution or Ca(2+) -free high K(+)  Krebs solution containing 1 mM EGTA.	k(+)  krebs	118-129	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22913344-10	2013	S1P (5x10(-7)  M) also induced significant tonic contractions in the lymph vessels that had been superfused with high K(+)  Krebs-bicarbonate solution or Ca(2+) -free high K(+)  Krebs solution containing 1 mM EGTA.	Bicarbonates	130-141	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22913344-10	2013	S1P (5x10(-7)  M) also induced significant tonic contractions in the lymph vessels that had been superfused with high K(+)  Krebs-bicarbonate solution or Ca(2+) -free high K(+)  Krebs solution containing 1 mM EGTA.	k(+)  krebs	172-183	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22913344-10	2013	S1P (5x10(-7)  M) also induced significant tonic contractions in the lymph vessels that had been superfused with high K(+)  Krebs-bicarbonate solution or Ca(2+) -free high K(+)  Krebs solution containing 1 mM EGTA.	Egtazic Acid	209-213	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22940715-3	2012	S1P generation is dependent on SK phosphorylation of sphingosine.	Sphingosine	53-64	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22933630-1	2012	Gradients of the sphingolipid sphingosine-1-phosphate (S1P) are responsible for the egress of lymphocytes from lymph nodes by activating the S1P1 receptor expressed on the surface of lymphocytes.	Sphingolipids	17-29	sphingosine-1-phosphate receptor 1	Mus musculus	141-145
22923732-1	2012	The lipid mediator sphingosine-1-phosphate (S1P) is generated within cells from sphingosine by two sphingosine kinases (SPHK1 and SPHK2).	Sphingosine	19-30	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
23148237-5	2012	Correspondingly, mice lacking the S1P receptor S1pr1 develop severe thrombocytopenia caused by both formation of aberrant extravascular PPs and defective intravascular PP shedding.	Pentosan Sulfuric Polyester	136-139	sphingosine-1-phosphate receptor 1	Mus musculus	47-52
22908849-7	2012	In wild-type MEFs, acetylation of histone 3-Lys9 was increased by the S1P lyase inhibitor 4-deoxypyridoxine.	3-lys9	42-48	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
22908849-7	2012	In wild-type MEFs, acetylation of histone 3-Lys9 was increased by the S1P lyase inhibitor 4-deoxypyridoxine.	4-deoxypyridoxine	90-107	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
22933630-1	2012	Gradients of the sphingolipid sphingosine-1-phosphate (S1P) are responsible for the egress of lymphocytes from lymph nodes by activating the S1P1 receptor expressed on the surface of lymphocytes.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	141-145
22933630-1	2012	Gradients of the sphingolipid sphingosine-1-phosphate (S1P) are responsible for the egress of lymphocytes from lymph nodes by activating the S1P1 receptor expressed on the surface of lymphocytes.	sphingosine 1-phosphate	55-58	sphingosine-1-phosphate receptor 1	Mus musculus	141-145
22732087-8	2012	Prostaglandin levels increased over 6h, while S1P and sphingosine level decreased during the same time, which makes an induction of prostanoid synthesis by S1P in zymosan-induced inflammation unlikely.	Prostaglandins	132-142	sphingosine-1-phosphate receptor 1	Mus musculus	156-159
22732087-8	2012	Prostaglandin levels increased over 6h, while S1P and sphingosine level decreased during the same time, which makes an induction of prostanoid synthesis by S1P in zymosan-induced inflammation unlikely.	Zymosan	163-170	sphingosine-1-phosphate receptor 1	Mus musculus	156-159
22732087-1	2012	Sphingosine-1-phosphate (S1P) is generated through phosphorylation of sphingosine by two sphingosine kinases (SPHK-1 and -2).	Sphingosine	70-81	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22855711-2	2012	Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from kidney IRI occurs in S1P3-deficient mice.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	83-89
22732087-3	2012	In addition, S1P induces cyclooxygenase-2 (COX-2) expression and the synthesis of proinflammatory prostanoids in several cell types.	Prostaglandins	98-109	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
22781001-1	2012	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in immunity, inflammation, angiogenesis, and cancer.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22884261-3	2012	Through chemical isolation and activity profiling, we identified serum-derived sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) as small molecule activators of YAP.	sphingosine 1-phosphate	79-102	sphingosine-1-phosphate receptor 1	Mus musculus	104-107
22221312-4	2012	KEY RESULTS: Stimulation with the TZDs, troglitazone and rosiglitazone, led to increased S1P levels in rat mesangial cells.	Thiazolidinediones	34-38	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
22707406-2	2012	We show that this communication occurs via sphingosine 1-phosphate (S1P) generated systemically by sphingosine kinase 1 (SK1), rather than via tumour-derived S1P.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
22753935-11	2012	The downregulation of S1PR1 and SPL1 expression in alcohol-consuming, melanoma-bearing mice could be associated with compromised egress of B cells from the spleen.	Alcohols	51-58	sphingosine-1-phosphate receptor 1	Mus musculus	22-27
22664872-1	2012	Sphingosine-1-phosphate (S1P) is lipid messenger involved in the regulation of embryonic development, immune system functions, and many other physiological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22773559-8	2012	CONCLUSIONS: Two percent isoflurane can suppress post-SAH blood-brain barrier disruption, which may be mediated by sphingosine kinase 1 expression and sphingosine-1-phosphate receptor-1/3 activation.	Isoflurane	25-35	sphingosine-1-phosphate receptor 1	Mus musculus	151-187
22698985-7	2012	Mice receiving fenofibrate had reduced suprarenal aortic diameter, reduced aortic arch Sudan IV staining, higher serum HDL levels, increased serum S1P concentrations, and increased aortic Akt1 and eNOS activities compared with control mice.	Fenofibrate	15-26	sphingosine-1-phosphate receptor 1	Mus musculus	147-150
22698985-8	2012	Macrophages, T lymphocytes, and apoptotic cells were less evident and eNOS, iNOS, and S1P receptors 1 and 3 were up-regulated in aortas from mice receiving fenofibrate.	Fenofibrate	156-167	sphingosine-1-phosphate receptor 1	Mus musculus	86-107
22698985-9	2012	The present findings suggest that fenofibrate antagonizes AngII-induced AAA and atherosclerosis by up-regulating serum HDL and S1P levels, with associated activation of NO-producing enzymes and reduction of aortic inflammation.	Fenofibrate	34-45	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
22221312-4	2012	KEY RESULTS: Stimulation with the TZDs, troglitazone and rosiglitazone, led to increased S1P levels in rat mesangial cells.	Troglitazone	40-52	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
22221312-4	2012	KEY RESULTS: Stimulation with the TZDs, troglitazone and rosiglitazone, led to increased S1P levels in rat mesangial cells.	Rosiglitazone	57-70	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
22221312-6	2012	GW-9662, a PPARgamma antagonist, inhibited the stimulating effect of TZDs on SK-1 mRNA and activity levels and intracellular S1P concentrations.	2-chloro-5-nitrobenzanilide	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	125-128
22500954-0	2012	Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).	1,2,4-Thiadiazole	19-36	sphingosine-1-phosphate receptor 1	Mus musculus	86-128
22393932-2	2012	In this study, we examined whether the formation of sphingosine 1-phosphate (S1P), a ceramide metabolite, is associated with this apoptotic pathway.	sphingosine 1-phosphate	52-75	sphingosine-1-phosphate receptor 1	Mus musculus	77-80
22393932-2	2012	In this study, we examined whether the formation of sphingosine 1-phosphate (S1P), a ceramide metabolite, is associated with this apoptotic pathway.	Ceramides	85-93	sphingosine-1-phosphate receptor 1	Mus musculus	77-80
22393932-6	2012	Ethanol exposure in 7-day-old mice induced sphingosine kinase 2 activation and increased the brain level of S1P transiently 2-4 h after exposure, followed by caspase 3 activation that peaked around 8 h after exposure.	Ethanol	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	108-111
22393932-8	2012	These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain.	Ethanol	28-35	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
22393932-8	2012	These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain.	Ethanol	158-165	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
22228496-2	2012	Circulating ceramide (Cer) and sphingosine 1-phosphate (S1P) are elevated in genetically obese (ob/ob) mice.	sphingosine 1-phosphate	31-54	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
22500954-0	2012	Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).	1,2,4-Thiadiazole	19-36	sphingosine-1-phosphate receptor 1	Mus musculus	130-136
22500954-1	2012	A novel series of 1,2,4-thiadiazole compounds was discovered as selective S1P(1) agonists.	1,2,4-Thiadiazole	18-35	sphingosine-1-phosphate receptor 1	Mus musculus	74-80
22265714-1	2012	Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking via type-1 S1P receptor (S1P(1)) and participates in many pathological conditions.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22354109-3	2012	By staining tumour-derived single cell suspensions with antibodies specific to ceramide and sphingosine 1-phosphate (S1P) followed by flow cytometry, we were able to document changes in the levels of these two key SLs in cancer cells and tumour-associated macrophages (TAMs) of mouse SCCVII tumours following PDT.	sphingosine 1-phosphate	92-115	sphingosine-1-phosphate receptor 1	Mus musculus	117-120
22389505-6	2012	Interestingly, rises in S1P correlate with increased glucose-stimulated insulin secretion (GSIS).	Glucose	53-60	sphingosine-1-phosphate receptor 1	Mus musculus	24-27
22389505-10	2012	Altogether, our data suggest that glucose activates SphK2 in pancreatic beta cells leading to a rise in S1P levels, which is important for GSIS.	Glucose	34-41	sphingosine-1-phosphate receptor 1	Mus musculus	104-107
22389505-0	2012	Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.	Glucose	40-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22389505-4	2012	Our studies in MIN6 cells and mouse pancreatic islets demonstrate that glucose stimulates an intracellular rise in the sphingolipid, sphingosine 1-phosphate (S1P), whereas the levels of ceramide and sphingomyelin remain unchanged.	Glucose	71-78	sphingosine-1-phosphate receptor 1	Mus musculus	158-161
22389505-5	2012	The increase in S1P levels by glucose is due to activation of sphingosine kinase 2 (SphK2).	Glucose	30-37	sphingosine-1-phosphate receptor 1	Mus musculus	16-19
22265714-1	2012	Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking via type-1 S1P receptor (S1P(1)) and participates in many pathological conditions.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
22265714-1	2012	Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking via type-1 S1P receptor (S1P(1)) and participates in many pathological conditions.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	88-94
22265714-2	2012	We developed a novel type S1P(1)-selective antagonist, TASP0251078, which is structurally unrelated to S1P.	3-chloro-N-((1R)-1-(4-ethyl-5-methoxy-4H-1,2,4-triazol-3-yl)ethyl)-4-fluorobenzenesulfonamide	55-66	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
22265714-3	2012	This competitive antagonist inhibited binding of S1P to S1P(1) resulting in reduced signaling downstream of S1P(1), including GTPgammaS-binding and cAMP formation.	Cyclic AMP	148-152	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
22265714-3	2012	This competitive antagonist inhibited binding of S1P to S1P(1) resulting in reduced signaling downstream of S1P(1), including GTPgammaS-binding and cAMP formation.	Cyclic AMP	148-152	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
22265714-3	2012	This competitive antagonist inhibited binding of S1P to S1P(1) resulting in reduced signaling downstream of S1P(1), including GTPgammaS-binding and cAMP formation.	Cyclic AMP	148-152	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
22265714-4	2012	TASP0251078 also inhibited S1P-induced cellular responses such as chemotaxis and receptor-internalization.	3-chloro-N-((1R)-1-(4-ethyl-5-methoxy-4H-1,2,4-triazol-3-yl)ethyl)-4-fluorobenzenesulfonamide	0-11	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
22178384-0	2012	Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
22279055-0	2012	S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.	Reactive Oxygen Species	78-81	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22279055-5	2012	Importantly, we found that S1P induced SDF-1 secretion from BM stromal cells including Nestin(+) mesenchymal stem cells via reactive oxygen species (ROS) signaling.	Reactive Oxygen Species	124-147	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
22279055-5	2012	Importantly, we found that S1P induced SDF-1 secretion from BM stromal cells including Nestin(+) mesenchymal stem cells via reactive oxygen species (ROS) signaling.	Reactive Oxygen Species	149-152	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
22279055-6	2012	Moreover, elevated ROS production by hematopoietic progenitor cells is also regulated by S1P.	Reactive Oxygen Species	19-22	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
22279055-7	2012	Our findings reveal that the S1P/S1P(1) axis regulates progenitor cell egress and mobilization via activation of ROS signaling on both hematopoietic progenitors and BM stromal cells, and SDF-1 release.	Reactive Oxygen Species	113-116	sphingosine-1-phosphate receptor 1	Mus musculus	29-32
22279055-7	2012	Our findings reveal that the S1P/S1P(1) axis regulates progenitor cell egress and mobilization via activation of ROS signaling on both hematopoietic progenitors and BM stromal cells, and SDF-1 release.	Reactive Oxygen Species	113-116	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
22406534-1	2012	The bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) promotes the egress of newly formed T cells from the thymus and the release of immature B cells from the bone marrow.	Lysophospholipids	14-30	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
22406534-1	2012	The bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) promotes the egress of newly formed T cells from the thymus and the release of immature B cells from the bone marrow.	sphingosine 1-phosphate	40-63	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
22234485-1	2012	Sphingosine 1-phosphate (S1P), a lysosphingolipid associated with high-density lipoprotein (HDL), contributes to the anti-atherogenic potential attributed to this lipoprotein.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22234485-1	2012	Sphingosine 1-phosphate (S1P), a lysosphingolipid associated with high-density lipoprotein (HDL), contributes to the anti-atherogenic potential attributed to this lipoprotein.	Sphingolipids	33-49	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22178384-2	2012	In this study the effect of the bioactive sphingolipid sphingosine 1-phosphate (S1P) on the proliferative and migratory response of murine satellite cells has been examined.	Sphingolipids	42-54	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
22178384-2	2012	In this study the effect of the bioactive sphingolipid sphingosine 1-phosphate (S1P) on the proliferative and migratory response of murine satellite cells has been examined.	sphingosine 1-phosphate	55-78	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
22178384-3	2012	S1P was found to stimulate labeled thymidine incorporation in a phosphatidylinositol 3-kinase-dependent manner.	Thymidine	35-44	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22298596-1	2012	Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that promotes breast cancer progression by diverse mechanisms that remain somewhat unclear.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21769103-5	2012	We found that the concentrations of sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) increase in the BM after conditioning for transplantation and that both S1P and, as we show here for the first time, C1P are potent chemoattractants for HSPCs.	ceramide 1-phosphate	70-90	sphingosine-1-phosphate receptor 1	Mus musculus	169-172
22049516-4	2012	We also demonstrate that the S1P(1) agonist SEW2871 increases AMD3100-induced HSC and progenitor cell mobilization.	SEW2871	44-51	sphingosine-1-phosphate receptor 1	Mus musculus	29-32
22919395-2	2012	To investigate the mechanism(s) responsible, we profiled inflammatory biomarkers and circulating levels of the bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) in control and anemic mice with or without LPS-induced systemic inflammation.	Lysophospholipids	121-137	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
22919395-2	2012	To investigate the mechanism(s) responsible, we profiled inflammatory biomarkers and circulating levels of the bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) in control and anemic mice with or without LPS-induced systemic inflammation.	sphingosine 1-phosphate	147-170	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
21980034-6	2012	Endothelial cells treated with alphavbeta3 antibodies were evaluated for sphingosine-1 phosphate (S1P)-mediated alterations in barrier function, cytoskeletal arrangement, and integrin localization.	sphingosine 1-phosphate	73-96	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
22153936-0	2012	Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.	1,2-DIHYDRONAPHTHALENE	63-81	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
22131329-1	2012	Sphingosine 1-phosphate (S1P) regulates lymphocyte trafficking through the type 1 sphingosine 1-phosphate receptor (S1P(1)) and participates in many pathological conditions, including autoimmune diseases.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	75-122
22131329-2	2012	We developed a novel S1P(1)-selective antagonist, TASP0277308, which is structurally unrelated to S1P.	TASP0277308	50-61	sphingosine-1-phosphate receptor 1	Mus musculus	21-27
21302134-2	2012	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that enhances vascular barrier function and has anti-inflammatory effects.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22020265-5	2012	METHODS AND RESULTS: Human epithelial colorectal CaCo2 cells stimulated in vitro with S1P revealed a decrease of transepithelial resistance and enhanced transport of FITC labeled OVA.	Fluorescein-5-isothiocyanate	166-170	sphingosine-1-phosphate receptor 1	Mus musculus	86-89
23029087-3	2012	However, the response of these cells to the S1PR1-specific agonist SEW2871 was only reduced on the first day after T cell activation with normal receptor-mediated Akt-phosphorylation restored by day 3.	SEW2871	67-74	sphingosine-1-phosphate receptor 1	Mus musculus	44-49
21632869-1	2011	Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration.	Phospholipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22723910-1	2012	Sphingosine-1-phosphate (S1P), a sphingolipid metabolite that is produced inside the cells, regulates a variety of physiological and pathological responses via S1P receptors (S1P1-5).	Sphingolipids	33-45	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22723910-1	2012	Sphingosine-1-phosphate (S1P), a sphingolipid metabolite that is produced inside the cells, regulates a variety of physiological and pathological responses via S1P receptors (S1P1-5).	Sphingolipids	33-45	sphingosine-1-phosphate receptor 1	Mus musculus	175-181
21848514-2	2011	S1P, which signals via a set of five G-protein-coupled receptors (S1P1-S1P5), is formed by the action of two SphKs (sphingosine kinases) from Sph (sphingosine).	Sphingosine	116-127	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
21944699-1	2011	BACKGROUND: Apolipoprotein M (apoM) has been identified as a specific sphingosine-1-phosphate (S1P) binding protein of HDL.	sphingosine 1-phosphate	70-93	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21944699-7	2011	S1P levels in apoB-depleted plasma correlated significantly with HDL-cholesterol and less so with apoM both if apoA-I plasma concentrations were below the median.	Cholesterol	69-80	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
21864273-2	2011	Investigations of sphingosine kinases (SphK) and sphingosine 1 phosphate (S1P) in TNFalpha driven murine models of rheumatoid arthritis (RA), identified SphK/S1P as important intermediaries in TNFalpha mediated synovial proinflammatory pathways.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
22314562-12	2011	Sphingosine, a direct precursor of S1P, in a high dose is cardiotoxic.	Sphingosine	0-11	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
22314562-14	2011	Therefore, the two latter sphingolipids may counteract, to a certain degree, the cardioprotective action of S1P.	Sphingolipids	26-39	sphingosine-1-phosphate receptor 1	Mus musculus	108-111
21798372-0	2011	The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.	W146	51-55	sphingosine-1-phosphate receptor 1	Mus musculus	4-38
21798372-8	2011	Our study demonstrates that a S1P1 antagonist, W146, induces a significant but transient blood lymphopenia in mice and a parallel increase in CD4+ and CD8+ lymphocytes in lymph nodes.	W146	47-51	sphingosine-1-phosphate receptor 1	Mus musculus	30-34
21712494-4	2011	Sphingolipid involvement in murine RILI was confirmed by radiation-induced increases in lung expression of sphingosine kinase (SphK) isoforms 1 and 2 and increases in the ratio of ceramide to sphingosine 1-phosphate (S1P) and dihydro-S1P (DHS1P) levels in plasma, bronchoalveolar lavage fluid, and lung tissue.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	217-220
21712494-4	2011	Sphingolipid involvement in murine RILI was confirmed by radiation-induced increases in lung expression of sphingosine kinase (SphK) isoforms 1 and 2 and increases in the ratio of ceramide to sphingosine 1-phosphate (S1P) and dihydro-S1P (DHS1P) levels in plasma, bronchoalveolar lavage fluid, and lung tissue.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	234-237
21632869-1	2011	Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration.	Phospholipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	100-103
21632869-1	2011	Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and migration.	Phospholipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	100-103
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	Fingolimod Hydrochloride	100-106	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	Fingolimod Hydrochloride	100-106	sphingosine-1-phosphate receptor 1	Mus musculus	227-230
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	Fingolimod Hydrochloride	108-118	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	Fingolimod Hydrochloride	108-118	sphingosine-1-phosphate receptor 1	Mus musculus	227-230
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol	120-170	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
21632869-3	2011	An impetus for the characterization of S1P-initiated signaling effects came with the discovery that FTY720 [fingolimod; 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] modulates the immune system by acting as an agonist at S1P(1).	2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol	120-170	sphingosine-1-phosphate receptor 1	Mus musculus	227-230
21632869-5	2011	Here, we present a pharmacological profile of a lead S1P(1/3) antagonist prodrug, 1-(hydroxymethyl)-3-(3-octylphenyl)cyclobutane (VPC03090).	1-(hydroxymethyl)-3-(3-octylphenyl)cyclobutane	82-128	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane	94-145	sphingosine-1-phosphate receptor 1	Mus musculus	260-263
21632869-6	2011	VPC03090 is phosphorylated by sphingosine kinase 2 to form the competitive antagonist species 3-(3-octylphenyl)-1-(phosphonooxymethyl)cyclobutane (VPC03090-P) as observed in guanosine 5"-O-(3-[(35)S]thio)triphosphate binding assays, with effects on downstream S1P receptor signaling confirmed by Western blot and calcium mobilization assays.	VPC03090-P	147-157	sphingosine-1-phosphate receptor 1	Mus musculus	260-263
21641216-0	2011	Discovery of S1P agonists with a dihydronaphthalene scaffold.	1,2-DIHYDRONAPHTHALENE	33-51	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
21136155-3	2011	Our new studies suggest that ceramide and its derivative, sphingosine-1-phosphate (S1P), act synergistically on embryonic stem (ES) cell differentiation.	Ceramides	29-37	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
21136155-6	2011	In contrast, ES cell-derived NPCs expressed S1P1 and were protected in the presence of S1P or its pro-drug analog FTY720.	Einsteinium	13-15	sphingosine-1-phosphate receptor 1	Mus musculus	44-48
21136155-6	2011	In contrast, ES cell-derived NPCs expressed S1P1 and were protected in the presence of S1P or its pro-drug analog FTY720.	Einsteinium	13-15	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
21148740-5	2011	LPS challenge of wild-type mice receiving 2-acetyl-4(5)-[1(R),2(S),3(R),4-tetrahydroxybutyl]-imidazole to inhibit S1PL or S1PL(+/-) mice resulted in increased S1P levels in lung tissue and bronchoalveolar lavage fluids and reduced lung injury and inflammation.	2-acetyl-4(5)-[1(r),2(s),3(r),4-tetrahydroxybutyl]-imidazole	42-102	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
21641216-2	2011	Cinnamyl derivative 1 was modified to improve S1P(1) agonistic activity as well as selectivity over S1P(3) agonistic activity.	cinnamyl	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
21641216-2	2011	Cinnamyl derivative 1 was modified to improve S1P(1) agonistic activity as well as selectivity over S1P(3) agonistic activity.	cinnamyl	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	100-103
21641216-3	2011	Dihydronaphthalene derivative 10d was identified as a potent S1P(1) receptor agonist with high selectivity against S1P(3) and enhanced efficacy in lowering peripheral lymphocyte counts in mice.	1,2-DIHYDRONAPHTHALENE	0-18	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
21256191-1	2011	BACKGROUND: Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite synthesized after stimulation with growth factors or cytokines.	Sphingolipids	47-59	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
21145832-12	2011	Furthermore, the effect of S1P was mimicked by SEW2871 (an S1P(1) agonist), and blocked by suramin (an S1P(3) antagonist) and by silencing S1P(1,3) expression.	SEW2871	47-54	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
21145832-12	2011	Furthermore, the effect of S1P was mimicked by SEW2871 (an S1P(1) agonist), and blocked by suramin (an S1P(3) antagonist) and by silencing S1P(1,3) expression.	SEW2871	47-54	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
21145832-12	2011	Furthermore, the effect of S1P was mimicked by SEW2871 (an S1P(1) agonist), and blocked by suramin (an S1P(3) antagonist) and by silencing S1P(1,3) expression.	SEW2871	47-54	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
21145832-12	2011	Furthermore, the effect of S1P was mimicked by SEW2871 (an S1P(1) agonist), and blocked by suramin (an S1P(3) antagonist) and by silencing S1P(1,3) expression.	SEW2871	47-54	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
21145832-12	2011	Furthermore, the effect of S1P was mimicked by SEW2871 (an S1P(1) agonist), and blocked by suramin (an S1P(3) antagonist) and by silencing S1P(1,3) expression.	Suramin	91-98	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
21145832-13	2011	In contrast, JTE-013 (an S1P(2) antagonist) and silencing of S1P(2) expression enhanced S1P-induced migration.	JTE 013	13-20	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21335477-1	2011	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
22140630-1	2011	This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
22140630-3	2011	The S1P(4) receptor agonists phytosphingosine-1-phospate and VPC23153, but not the dual S1P(1 and 3) receptor agonist VPC24191, caused dose-dependent vasoconstrictions.	phytosphingosine-1-phospate	29-56	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
21606363-1	2011	Protection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity.	sphingosine 1-phosphate	57-80	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
21335477-9	2011	When given overnight at 25 mg/l in drinking water, THI raised S1P levels and reduced SPL activity (n = 5, P &lt; 0.01).	2-acetyl-4(5)-tetrahydroxybutylimidazole	51-54	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
21335477-12	2011	Pretreatment with an S1P1 and S1P3 receptor antagonist partially reversed the effects of THI.	2-acetyl-4(5)-tetrahydroxybutylimidazole	89-92	sphingosine-1-phosphate receptor 1	Mus musculus	21-43
21435724-7	2011	To further characterize SphK1-dependent IL-12p70 regulation we exogenously applied S1P, SEW2871 and the new potent S1P1 agonist CYM5442.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	128-135	sphingosine-1-phosphate receptor 1	Mus musculus	115-119
21256191-7	2011	RESULTS: This study demonstrates, in NIH 3T3 fibroblasts, a novel redox regulated mechanism of S1P-induced activation of ERK 1/2 related to NADPH oxidase activity and intracellular H(2)O(2) level increase with PDGF receptor tyrosine kinase involvement through a transactivation mechanism.	Hydrogen Peroxide	181-189	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21251196-1	2011	BACKGROUND: Platelets release the immune-modulating lipid sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	58-81	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
21251196-3	2011	OBJECTIVES: The present study investigates the function of thromboxane (TX) for platelet S1P secretion during platelet activation and the consequences for monocyte chemotaxis.	Thromboxanes	59-70	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
21251196-4	2011	METHODS: S1P was detected using thin-layer chromatography in [(3)H]sphingosine-labeled platelets and by mass spectrometry.	[(3)h]sphingosine	61-78	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
21251196-7	2011	Acetylsalicylic acid (ASA) and two structurally unrelated reversible cyclooxygenase inhibitors diclofenac and ibuprofen suppressed S1P release.	Aspirin	0-20	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
21251196-7	2011	Acetylsalicylic acid (ASA) and two structurally unrelated reversible cyclooxygenase inhibitors diclofenac and ibuprofen suppressed S1P release.	Aspirin	22-25	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
21251196-7	2011	Acetylsalicylic acid (ASA) and two structurally unrelated reversible cyclooxygenase inhibitors diclofenac and ibuprofen suppressed S1P release.	Ibuprofen	110-119	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
21251196-8	2011	Oral ASA (500-mg single dose or 100 mg over 3 days) attenuated S1P release from platelets in healthy human volunteers ex vivo.	Aspirin	5-8	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
21251196-10	2011	S1P release was increased by the TX receptor (TP) agonist U-46619, and inhibited by the TP antagonist ramatroban and by inhibitors of ABC-transport.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid	58-65	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
21251196-11	2011	Furthermore, thrombin-induced release of S1P was attenuated in platelets from TP-deficient mice.	neotetrazolium	78-80	sphingosine-1-phosphate receptor 1	Mus musculus	41-44
20959514-1	2011	The potent lipid mediator sphingosine-1-phosphate (S1P) regulates diverse physiological processes by binding to 5 specific GPCRs, although it also has intracellular targets.	sphingosine 1-phosphate	26-49	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
21209394-2	2011	Accumulating evidence suggests that the bioactive sphingolipids, such as sphingosine-1-phosphate (S1P) and its generating enzyme, sphingosine kinase 1 (SphK1) play pivotal roles in several important biological functions including promoting tumor growth and carcinogenesis.	Sphingolipids	50-63	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
21209394-8	2011	Remarkably, we found that the genetic loss of SphK1, which reduced S1P generation, significantly prevented 4-NQO-induced HNSCC carcinogenesis, with decreased tumor incidence, multiplicity, and volume when compared with controls.	4-Nitroquinoline-1-oxide	107-112	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
21292568-1	2011	D-erythro-sphingosine (Sph) and its phosphorylated product, d-erythro-sphingosine 1-phosphate (S1P) are sphingolipids mediating numerous cellular processes.	Sphingosine	0-21	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21292568-1	2011	D-erythro-sphingosine (Sph) and its phosphorylated product, d-erythro-sphingosine 1-phosphate (S1P) are sphingolipids mediating numerous cellular processes.	Sphingosine	23-26	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21292568-1	2011	D-erythro-sphingosine (Sph) and its phosphorylated product, d-erythro-sphingosine 1-phosphate (S1P) are sphingolipids mediating numerous cellular processes.	sphingosine 1-phosphate	60-93	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21292568-1	2011	D-erythro-sphingosine (Sph) and its phosphorylated product, d-erythro-sphingosine 1-phosphate (S1P) are sphingolipids mediating numerous cellular processes.	Sphingolipids	104-117	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
21292568-11	2011	The method was applied to simultaneously determine the Sph and S1P levels in mouse kidney, human plasma, and HEK 293 cells treated with tumor necrosis factor-alpha (TNF-alpha) and N,N-dimethylsphingosine (DMS).	N,N-dimethylsphingosine	180-203	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
21292568-12	2011	The S1P levels increased in cells treated with TNF-alpha whereas decreased in cells treated with DMS.	N,N-dimethylsphingosine	97-100	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
21289303-1	2011	Sphingosine 1-phosphate (S1P) initiates T and B cell exit from lymphoid tissues by activating the S1P(1) receptor on lymphocytes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21289303-1	2011	Sphingosine 1-phosphate (S1P) initiates T and B cell exit from lymphoid tissues by activating the S1P(1) receptor on lymphocytes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
21289303-4	2011	Although Sphingomab blocked S1P(1)-mediated calcium flux and receptor downregulation by S1P in vitro, plasma from Sphingomab-treated mice demonstrated a 4-fold increase in S1P concentration and largely retained its stimulating activity on S1P receptors.	Calcium	44-51	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
21173151-1	2011	Sphingosine-1-phosphate (S1P) lyase catalyzes the degradation of S1P, a potent signaling lysosphingolipid.	Sphingolipids	89-105	sphingosine-1-phosphate receptor 1	Mus musculus	0-23
21173151-1	2011	Sphingosine-1-phosphate (S1P) lyase catalyzes the degradation of S1P, a potent signaling lysosphingolipid.	Sphingolipids	89-105	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21173151-1	2011	Sphingosine-1-phosphate (S1P) lyase catalyzes the degradation of S1P, a potent signaling lysosphingolipid.	Sphingolipids	89-105	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
21258214-1	2011	The balance between the pro-apoptotic lipids ceramide and sphingosine and the pro-survival lipid sphingosine 1-phosphate (S1P) is termed the "sphingosine rheostat".	sphingosine 1-phosphate	97-120	sphingosine-1-phosphate receptor 1	Mus musculus	122-125
21258214-1	2011	The balance between the pro-apoptotic lipids ceramide and sphingosine and the pro-survival lipid sphingosine 1-phosphate (S1P) is termed the "sphingosine rheostat".	Sphingosine	97-108	sphingosine-1-phosphate receptor 1	Mus musculus	122-125
21258214-2	2011	Two isozymes, sphingosine kinase 1 and 2 (SK1 and SK2), are responsible for phosphorylation of pro-apoptotic sphingosine to form pro-survival S1P.	Sphingosine	14-25	sphingosine-1-phosphate receptor 1	Mus musculus	142-145
21258214-7	2011	We also measured levels of S1P in the plasma of mice treated with two different doses of ABC294640 and sorafenib.	Sorafenib	103-112	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
21687504-4	2011	JTE-013 and BML-241 (also known as CAY10444), used extensively as specific S1P(2) and S1P(3) receptors antagonists respectively, are cases in point.	CAY10444	35-43	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
21687504-4	2011	JTE-013 and BML-241 (also known as CAY10444), used extensively as specific S1P(2) and S1P(3) receptors antagonists respectively, are cases in point.	CAY10444	35-43	sphingosine-1-phosphate receptor 1	Mus musculus	86-89
21687504-5	2011	When analyzing S1P-induced vasoconstriction in mouse basilar artery, we observed that JTE-013 inhibited not only the effect of S1P, but also the effect of U46619, endothelin-1 or high KCl; JTE-013 strongly inhibited responses to S1P in S1P(2) receptor knockout mice.	JTE 013	86-93	sphingosine-1-phosphate receptor 1	Mus musculus	15-18
21687504-5	2011	When analyzing S1P-induced vasoconstriction in mouse basilar artery, we observed that JTE-013 inhibited not only the effect of S1P, but also the effect of U46619, endothelin-1 or high KCl; JTE-013 strongly inhibited responses to S1P in S1P(2) receptor knockout mice.	JTE 013	86-93	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
21687504-5	2011	When analyzing S1P-induced vasoconstriction in mouse basilar artery, we observed that JTE-013 inhibited not only the effect of S1P, but also the effect of U46619, endothelin-1 or high KCl; JTE-013 strongly inhibited responses to S1P in S1P(2) receptor knockout mice.	JTE 013	86-93	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
21687504-5	2011	When analyzing S1P-induced vasoconstriction in mouse basilar artery, we observed that JTE-013 inhibited not only the effect of S1P, but also the effect of U46619, endothelin-1 or high KCl; JTE-013 strongly inhibited responses to S1P in S1P(2) receptor knockout mice.	JTE 013	86-93	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
21687504-7	2011	Another putative S1P(1/3) receptor antagonist, VPC23019, does not inhibit S1P(3)-mediated vasoconstriction.	VPC23019	47-55	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20709140-4	2011	These enzymes also hydrolyze extracellular sphingosine 1-phosphate (S1P), a potent signal for cell division, survival and angiogenesis.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
21829623-1	2011	Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like proliferation, death, migration and cytokine production.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21556483-2	2011	Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21556483-2	2011	Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	76-89	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	91-94	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	159-162	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
22096531-1	2011	BACKGROUND: Lysophospholipids such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are important signaling molecules that can regulate a wide range of cellular responses.	Lysophospholipids	12-29	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
20935081-9	2011	Specific S1P1 agonism in lungs contributes significantly to anti-inflammatory activities of sphingosine-1-phosphate therapeutics by suppressing chemokine release in the airways, and may be of clinical relevance.	sphingosine 1-phosphate	92-115	sphingosine-1-phosphate receptor 1	Mus musculus	9-13
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	48-52
21876704-2	2011	The cardinal members of this signalling molecule group are sphingosylphosphorylcholine (SPC), lysophosphatidic acid (LPA), and sphingosine 1-phosphate (S1P) which are, at least in part, homologous to each other.	sphingosine 1-phosphate	127-150	sphingosine-1-phosphate receptor 1	Mus musculus	152-155
21118968-1	2010	A previous in vitro study showed that sphingosine-1-phosphate (S1P), a ceramide antagonist, preserved endothelial cells in culture from radiation-induced apoptosis.	Ceramides	71-79	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	0-10	sphingosine-1-phosphate receptor 1	Mus musculus	150-154
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	133-143	sphingosine-1-phosphate receptor 1	Mus musculus	48-52
24900286-0	2011	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS. We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity.	benzofuran	133-143	sphingosine-1-phosphate receptor 1	Mus musculus	150-154
24900286-1	2011	1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with &gt;1000x selectivity over S1P3.	1-((4-(5-benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid	0-82	sphingosine-1-phosphate receptor 1	Mus musculus	100-104
20458606-1	2010	Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive lysophospholipids that affect various cellular processes through G protein-coupled receptors.	Lysophospholipids	76-93	sphingosine-1-phosphate receptor 1	Mus musculus	57-60
20938668-1	2010	Ethanolamine is a biogenic amine found naturally in the body as part of membrane lipids and as a metabolite of the cardioprotective substances, sphingosine-1-phosphate (S1P) and anandamide.	Ethanolamine	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	169-172
20938668-1	2010	Ethanolamine is a biogenic amine found naturally in the body as part of membrane lipids and as a metabolite of the cardioprotective substances, sphingosine-1-phosphate (S1P) and anandamide.	Amines	7-12	sphingosine-1-phosphate receptor 1	Mus musculus	169-172
20646989-0	2010	Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway.	Berberine	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
20646989-3	2010	Sphingosine kinase-Sphingosine 1-phosphate (SphK-S1P) signaling pathway has been implicated in the pathogenesis of diabetic nephropathy (DN).	sphingosine 1-phosphate	19-42	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
20646989-9	2010	These findings suggest that the inhibitory effect of BBR on the activation of SphK-S1P signaling pathway in diabetic mouse kidney is a novel mechanism by which BBR partly exerts renoprotective effects on DN.	Berberine	53-56	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
20646989-9	2010	These findings suggest that the inhibitory effect of BBR on the activation of SphK-S1P signaling pathway in diabetic mouse kidney is a novel mechanism by which BBR partly exerts renoprotective effects on DN.	Berberine	160-163	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
20802177-4	2010	A similar reduction of the late-phase reaction was observed by a sphingosine-1-phosphate G protein-coupled receptor (S1P1)-selective agonist, SEW2871.	SEW2871	142-149	sphingosine-1-phosphate receptor 1	Mus musculus	117-121
20688834-2	2010	These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	144-167	sphingosine-1-phosphate receptor 1	Mus musculus	169-172
19749179-2	2010	Extending our previous finding that the intravenous administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR(1), we determine that a direct intratracheal or intravenous administration of S1P, or a selective S1P receptor (S1PR(1)) agonist (SEW-2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung.	Sphingolipids	74-86	sphingosine-1-phosphate receptor 1	Mus musculus	131-134
19749179-2	2010	Extending our previous finding that the intravenous administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR(1), we determine that a direct intratracheal or intravenous administration of S1P, or a selective S1P receptor (S1PR(1)) agonist (SEW-2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung.	Sphingolipids	74-86	sphingosine-1-phosphate receptor 1	Mus musculus	215-222
19749179-2	2010	Extending our previous finding that the intravenous administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR(1), we determine that a direct intratracheal or intravenous administration of S1P, or a selective S1P receptor (S1PR(1)) agonist (SEW-2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung.	Sphingolipids	74-86	sphingosine-1-phosphate receptor 1	Mus musculus	215-218
19749179-2	2010	Extending our previous finding that the intravenous administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR(1), we determine that a direct intratracheal or intravenous administration of S1P, or a selective S1P receptor (S1PR(1)) agonist (SEW-2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung.	Sphingolipids	74-86	sphingosine-1-phosphate receptor 1	Mus musculus	215-218
19749179-2	2010	Extending our previous finding that the intravenous administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR(1), we determine that a direct intratracheal or intravenous administration of S1P, or a selective S1P receptor (S1PR(1)) agonist (SEW-2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung.	Sphingolipids	74-86	sphingosine-1-phosphate receptor 1	Mus musculus	332-339
20435688-6	2010	S1P-induced vasoconstriction was reduced by 64% by concomitant administration of the Rho-kinase inhibitor Y27632 (10 microM).	Y 27632	106-112	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
20554039-4	2010	The S1P-mediated contraction was abolished by JTE-013, a selective S1P receptor 2 (S1PR2) antagonist, but not by W123, a selective S1PR1 antagonist, and BML-241, a selective S1PR3 antagonist.	JTE 013	46-53	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
20554039-5	2010	The S1P-mediated contraction observed in BSMs of the control mice was also inhibited by Y-27632, a Rho-kinase inhibitor, suggesting that the contraction is mediated via activations of S1PR2 and probably its downstream Rho-kinase.	Y 27632	88-95	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
20522601-1	2010	Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that regulates numerous key cardiovascular functions.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	51-57	sphingosine-1-phosphate receptor 1	Mus musculus	206-209
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	51-57	sphingosine-1-phosphate receptor 1	Mus musculus	263-266
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	51-57	sphingosine-1-phosphate receptor 1	Mus musculus	263-266
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	Y 27632	161-167	sphingosine-1-phosphate receptor 1	Mus musculus	206-209
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	Y 27632	161-167	sphingosine-1-phosphate receptor 1	Mus musculus	263-266
20522601-10	2010	Treatment with the phospholipase C (PLC) inhibitor U73122, the protein kinase C (PKC) inhibitor RO-318425, or the Rho-associated protein kinase (ROCK) inhibitor Y27632 all significantly inhibited HDL3- and S1P-mediated PAI-1 release, suggesting that HDL3- and/or S1P-stimulated PAI-1 secretion from 3T3 cells is mediated by activation of multiple, downstream signaling pathways of S1P(2).	Y 27632	161-167	sphingosine-1-phosphate receptor 1	Mus musculus	263-266
20584883-4	2010	We characterize a knockin mouse (S1p1r(S5A/S5A)) in which the C-terminal serine-rich S1P(1) motif, which is important for S1P(1) internalization but dispensable for S1P(1) signaling, is mutated.	Serine	73-79	sphingosine-1-phosphate receptor 1	Mus musculus	85-91
20584883-4	2010	We characterize a knockin mouse (S1p1r(S5A/S5A)) in which the C-terminal serine-rich S1P(1) motif, which is important for S1P(1) internalization but dispensable for S1P(1) signaling, is mutated.	Serine	73-79	sphingosine-1-phosphate receptor 1	Mus musculus	122-128
20584883-4	2010	We characterize a knockin mouse (S1p1r(S5A/S5A)) in which the C-terminal serine-rich S1P(1) motif, which is important for S1P(1) internalization but dispensable for S1P(1) signaling, is mutated.	Serine	73-79	sphingosine-1-phosphate receptor 1	Mus musculus	122-128
20206620-2	2010	The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role in developmental angiogenesis.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
20123033-3	2010	Bacterial LPS increases the activity of sphingosine kinase 1 (SK1), which catalyzes formation of sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	97-120	sphingosine-1-phosphate receptor 1	Mus musculus	122-125
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	sphingosine 1-phosphate	7-30	sphingosine-1-phosphate receptor 1	Mus musculus	32-35
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	sphingosine 1-phosphate	7-30	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	Sphingosine	7-18	sphingosine-1-phosphate receptor 1	Mus musculus	32-35
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	Sphingosine	7-18	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	Sphingosine	145-148	sphingosine-1-phosphate receptor 1	Mus musculus	32-35
20207939-1	2010	Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown.	Sphingosine	145-148	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
20207939-7	2010	Such SPH and S1P increases were inhibited by the alkaline ceramidase inhibitor D-e-MAPP, suggesting that alkaline ceramidases have a role in the generation of SPH and S1P in erythroid cells.	2-(N-myristoylamino)-1-phenyl-1-propanol	79-87	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
20207939-7	2010	Such SPH and S1P increases were inhibited by the alkaline ceramidase inhibitor D-e-MAPP, suggesting that alkaline ceramidases have a role in the generation of SPH and S1P in erythroid cells.	2-(N-myristoylamino)-1-phenyl-1-propanol	79-87	sphingosine-1-phosphate receptor 1	Mus musculus	167-170
20207939-9	2010	Collectively, these results suggest that alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes.	Sphingosine	105-108	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
20206620-9	2010	The effects of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methylester, showed that PLGA-S1P-induced blood flow stimulation was partially dependent on nitric oxide.	Nitric Oxide	19-31	sphingosine-1-phosphate receptor 1	Mus musculus	106-109
20206620-9	2010	The effects of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methylester, showed that PLGA-S1P-induced blood flow stimulation was partially dependent on nitric oxide.	Nitric Oxide	168-180	sphingosine-1-phosphate receptor 1	Mus musculus	106-109
20407207-5	2010	Injection of S1P into Sphk1-/- mice increased histamine clearance and promoted recovery from anaphylaxis.	Histamine	46-55	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
19556602-1	2010	Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that plays important roles in allergic responses, including asthma.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
20407207-7	2010	Mice lacking the S1P receptor S1PR2 also showed a delay in plasma histamine clearance and a poor recovery from anaphylaxis.	Histamine	66-75	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20407207-10	2010	Thus, SphK1-produced S1P regulates blood pressure, histamine clearance, and recovery from anaphylaxis in a manner that involves S1PR2.	Histamine	51-60	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
20097939-8	2010	These results demonstrate that S1P lyase is a key regulator of the levels of multiple sphingolipid substrates and reveal functional links between the sphingolipid metabolic pathway and other lipid metabolic pathways that may be mediated by shared lipid substrates and changes in gene expression programs.	Sphingolipids	86-98	sphingosine-1-phosphate receptor 1	Mus musculus	31-34
20220090-6	2010	In contrast to wild-type mice, SK2(-/-) mice exhibited attenuated lymphopenia after S1P-lyase inhibition by 4-deoxypyridoxine (DOP).	4-deoxypyridoxine	108-125	sphingosine-1-phosphate receptor 1	Mus musculus	84-87
20220090-6	2010	In contrast to wild-type mice, SK2(-/-) mice exhibited attenuated lymphopenia after S1P-lyase inhibition by 4-deoxypyridoxine (DOP).	4-deoxypyridoxine	127-130	sphingosine-1-phosphate receptor 1	Mus musculus	84-87
20220090-8	2010	Low S1P concentrations in lymphoid tissues of DOP-treated SK2(-/-) mice were accompanied by higher S1P concentrations in blood, suggesting that SK2(-/-) mice display defective S1P transport from blood into lymphoid tissues.	4-deoxypyridoxine	46-49	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
20220090-8	2010	Low S1P concentrations in lymphoid tissues of DOP-treated SK2(-/-) mice were accompanied by higher S1P concentrations in blood, suggesting that SK2(-/-) mice display defective S1P transport from blood into lymphoid tissues.	4-deoxypyridoxine	46-49	sphingosine-1-phosphate receptor 1	Mus musculus	99-102
20220090-8	2010	Low S1P concentrations in lymphoid tissues of DOP-treated SK2(-/-) mice were accompanied by higher S1P concentrations in blood, suggesting that SK2(-/-) mice display defective S1P transport from blood into lymphoid tissues.	4-deoxypyridoxine	46-49	sphingosine-1-phosphate receptor 1	Mus musculus	99-102
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	sphingoid base phosphates	16-41	sphingosine-1-phosphate receptor 1	Mus musculus	45-68
20097939-8	2010	These results demonstrate that S1P lyase is a key regulator of the levels of multiple sphingolipid substrates and reveal functional links between the sphingolipid metabolic pathway and other lipid metabolic pathways that may be mediated by shared lipid substrates and changes in gene expression programs.	Sphingolipids	150-162	sphingosine-1-phosphate receptor 1	Mus musculus	31-34
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	sphingoid base phosphates	16-41	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
20061445-1	2010	Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P).	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	214-217
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	phosphorylethanolamine	92-111	sphingosine-1-phosphate receptor 1	Mus musculus	45-68
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	phosphorylethanolamine	92-111	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	Aldehydes	124-132	sphingosine-1-phosphate receptor 1	Mus musculus	45-68
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	Aldehydes	124-132	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	Sphingolipids	170-182	sphingosine-1-phosphate receptor 1	Mus musculus	45-68
20097939-1	2010	The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.	Sphingolipids	170-182	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
20097939-4	2010	Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol.	Sphingolipids	122-134	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20097939-4	2010	Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol.	Phospholipids	154-167	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20097939-4	2010	Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol.	triacyglycerol	169-183	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20097939-4	2010	Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol.	Diglycerides	185-199	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20097939-4	2010	Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol.	Cholesterol	205-216	sphingosine-1-phosphate receptor 1	Mus musculus	17-20
20061445-2	2010	Many growth factors and inflammatory cytokines promote the cleavage of sphingomyelin and ceramide leading to rapid elevation of S1P levels through the action of sphingosine kinases (SK1 and SK2).	Ceramides	89-97	sphingosine-1-phosphate receptor 1	Mus musculus	128-131
20061445-4	2010	We have identified an aryladamantane compound, termed ABC294640 [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], that selectively inhibits SK2 activity in vitro, acting as a competitive inhibitor with respect to sphingosine with a K(i) of 9.8 muM, and attenuates S1P formation in intact cells.	aryladamantane	22-36	sphingosine-1-phosphate receptor 1	Mus musculus	291-294
20061445-1	2010	Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	189-212	sphingosine-1-phosphate receptor 1	Mus musculus	214-217
20061445-2	2010	Many growth factors and inflammatory cytokines promote the cleavage of sphingomyelin and ceramide leading to rapid elevation of S1P levels through the action of sphingosine kinases (SK1 and SK2).	Sphingomyelins	71-84	sphingosine-1-phosphate receptor 1	Mus musculus	128-131
20152803-0	2010	Altered expression of sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 in mouse hippocampus after kainic acid treatment.	Kainic Acid	109-120	sphingosine-1-phosphate receptor 1	Mus musculus	47-81
20061445-4	2010	We have identified an aryladamantane compound, termed ABC294640 [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], that selectively inhibits SK2 activity in vitro, acting as a competitive inhibitor with respect to sphingosine with a K(i) of 9.8 muM, and attenuates S1P formation in intact cells.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide	54-63	sphingosine-1-phosphate receptor 1	Mus musculus	291-294
20061445-4	2010	We have identified an aryladamantane compound, termed ABC294640 [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], that selectively inhibits SK2 activity in vitro, acting as a competitive inhibitor with respect to sphingosine with a K(i) of 9.8 muM, and attenuates S1P formation in intact cells.	3-(4-chlorophenyl)-adamantane-1-carboxylic acid	65-112	sphingosine-1-phosphate receptor 1	Mus musculus	291-294
20061445-4	2010	We have identified an aryladamantane compound, termed ABC294640 [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], that selectively inhibits SK2 activity in vitro, acting as a competitive inhibitor with respect to sphingosine with a K(i) of 9.8 muM, and attenuates S1P formation in intact cells.	pyridin-4-ylmethyl)amide	114-138	sphingosine-1-phosphate receptor 1	Mus musculus	291-294
20061445-4	2010	We have identified an aryladamantane compound, termed ABC294640 [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], that selectively inhibits SK2 activity in vitro, acting as a competitive inhibitor with respect to sphingosine with a K(i) of 9.8 muM, and attenuates S1P formation in intact cells.	Sphingosine	240-251	sphingosine-1-phosphate receptor 1	Mus musculus	291-294
20036321-6	2010	Moreover, addition of sphingosine 1 phosphate (S1P), a breakdown product of sphingolipid metabolism, increased the expression levels of TNF-alpha, IL-1beta and iNOS and production of TNF-alpha and NO in activated microglia.	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
20036321-6	2010	Moreover, addition of sphingosine 1 phosphate (S1P), a breakdown product of sphingolipid metabolism, increased the expression levels of TNF-alpha, IL-1beta and iNOS and production of TNF-alpha and NO in activated microglia.	Sphingolipids	76-88	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
20061542-9	2010	ERK1/2 activation was through an S1P(1) subtype receptor-G(i) protein-dependent pathway, whereas the activation of Akt was inhibited by CAY10444, indicating mediation by S1P(3) subtype receptors.	CAY10444	136-144	sphingosine-1-phosphate receptor 1	Mus musculus	170-173
19965812-4	2010	METHODS: Concurrent to VEGFR blockade in mice, S1P signaling augmentation was achieved via treatment with the S1P precursor sphingosine, S1P agonist FTY720, or S1P receptor-1 (S1PR1) agonist SEW2871.	SEW2871	191-198	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
19913094-3	2010	Extracellular S1P activates specific G protein-coupled receptors while intracellular S1P can mobilize Ca2+ from thapsigargin-sensitive stores.	Thapsigargin	112-124	sphingosine-1-phosphate receptor 1	Mus musculus	85-88
19913094-6	2010	Measurements with fura-2-loaded cells in suspension revealed that resting [Ca2+]i was elevated and agonist-induced [Ca2+]i increases were augmented in S1P lyase-deficient MEFs both in the presence and absence of extracellular Ca2+.	Fura-2	18-24	sphingosine-1-phosphate receptor 1	Mus musculus	151-154
19913094-7	2010	Importantly, [Ca2+]i increases and Ca2+ mobilization induced by the SERCA inhibitor, thapsigargin, were augmented, indicating enhanced Ca2+ storage in S1P lyase-deficient MEFs.	Thapsigargin	85-97	sphingosine-1-phosphate receptor 1	Mus musculus	151-154
19913094-9	2010	The area under the time course of thapsigargin-induced [Ca2+]i increases, reflecting overall Ca2+ release, was significantly increased by more than 50% in both rapidly and slowly responding S1P lyase-deficient cells.	Thapsigargin	34-46	sphingosine-1-phosphate receptor 1	Mus musculus	190-193
20174580-1	2010	B lymphocyte egress from secondary lymphoid organs requires sphingosine-1-phosphate (S1P) and S1P receptor-1 (S1P1).	sphingosine 1-phosphate	60-83	sphingosine-1-phosphate receptor 1	Mus musculus	85-88
19965812-2	2010	The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism.	Ceramides	36-45	sphingosine-1-phosphate receptor 1	Mus musculus	90-93
19965812-2	2010	The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism.	Ceramides	36-44	sphingosine-1-phosphate receptor 1	Mus musculus	90-93
19965812-7	2010	Administration of sphingosine decreased the ceramide-to-S1P ratio in the lung and inhibited alveolar space enlargement, along with activation of prosurvival signaling pathways and decreased lung parenchyma cell apoptosis.	Sphingosine	18-29	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
19965812-4	2010	METHODS: Concurrent to VEGFR blockade in mice, S1P signaling augmentation was achieved via treatment with the S1P precursor sphingosine, S1P agonist FTY720, or S1P receptor-1 (S1PR1) agonist SEW2871.	Sphingosine	124-135	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
19773225-3	2010	METHODS AND RESULTS: Using a classical biochemical strategy, we isolated and identified sphingosine-1 phosphate (S1P) as a proliferative factor present in the plasma of patients with Fabry disease.	sphingosine 1-phosphate	88-111	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
19965812-4	2010	METHODS: Concurrent to VEGFR blockade in mice, S1P signaling augmentation was achieved via treatment with the S1P precursor sphingosine, S1P agonist FTY720, or S1P receptor-1 (S1PR1) agonist SEW2871.	Sphingosine	124-135	sphingosine-1-phosphate receptor 1	Mus musculus	110-113
19965812-4	2010	METHODS: Concurrent to VEGFR blockade in mice, S1P signaling augmentation was achieved via treatment with the S1P precursor sphingosine, S1P agonist FTY720, or S1P receptor-1 (S1PR1) agonist SEW2871.	Sphingosine	124-135	sphingosine-1-phosphate receptor 1	Mus musculus	110-113
19965812-4	2010	METHODS: Concurrent to VEGFR blockade in mice, S1P signaling augmentation was achieved via treatment with the S1P precursor sphingosine, S1P agonist FTY720, or S1P receptor-1 (S1PR1) agonist SEW2871.	Fingolimod Hydrochloride	149-155	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
20042570-3	2010	The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P(1)R).	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
20042570-3	2010	The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P(1)R).	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	114-128
20042570-3	2010	The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P(1)R).	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
20042570-6	2010	We identify the signaling mechanisms used by S1P(2)R in macrophages, involving the second messenger cAMP and inhibition of Akt phosphorylation.	Cyclic AMP	100-104	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
20026661-1	2010	Lymphocyte egress from lymph nodes (LNs) is dependent on sphingosine-1-phosphate (S1P), but the cellular source of this S1P is not defined.	sphingosine 1-phosphate	57-80	sphingosine-1-phosphate receptor 1	Mus musculus	82-85
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	Sphingolipids	42-54	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	Sphingolipids	42-54	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
20060809-1	2010	Sphingosine 1-phosphate (S1P) is a potent sphingolipid mediator that acts through five cognate G protein-coupled receptors (S1P(1)-S1P(5)) and regulates many critical biological processes.	Sphingolipids	42-54	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
20060809-4	2010	In this study, we investigated the potential role of S1P(2) in streptozotocin (STZ)-induced apoptosis of pancreatic beta-cells and progression of diabetes.	Streptozocin	63-77	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
20060809-4	2010	In this study, we investigated the potential role of S1P(2) in streptozotocin (STZ)-induced apoptosis of pancreatic beta-cells and progression of diabetes.	Streptozocin	79-82	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
20060809-5	2010	S1P(2)-deficient (S1P(2)(-/-)) mice displayed a greater survive ability, lower blood glucose levels, and smaller numbers of TUNEL-positive apoptotic beta-cells to administration of a high dose of STZ than wild-type (WT) mice.	Glucose	85-92	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
20060809-5	2010	S1P(2)-deficient (S1P(2)(-/-)) mice displayed a greater survive ability, lower blood glucose levels, and smaller numbers of TUNEL-positive apoptotic beta-cells to administration of a high dose of STZ than wild-type (WT) mice.	Glucose	85-92	sphingosine-1-phosphate receptor 1	Mus musculus	18-21
20060809-5	2010	S1P(2)-deficient (S1P(2)(-/-)) mice displayed a greater survive ability, lower blood glucose levels, and smaller numbers of TUNEL-positive apoptotic beta-cells to administration of a high dose of STZ than wild-type (WT) mice.	Streptozocin	196-199	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
20060809-5	2010	S1P(2)-deficient (S1P(2)(-/-)) mice displayed a greater survive ability, lower blood glucose levels, and smaller numbers of TUNEL-positive apoptotic beta-cells to administration of a high dose of STZ than wild-type (WT) mice.	Streptozocin	196-199	sphingosine-1-phosphate receptor 1	Mus musculus	18-21
20060809-6	2010	S1P(2)(-/-) mice showed higher insulin/glucose ratios (an index of relative insulin deficiency) and larger insulin-positive islet areas to administration of a low dose of STZ than WT mice.	Glucose	39-46	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
20060809-6	2010	S1P(2)(-/-) mice showed higher insulin/glucose ratios (an index of relative insulin deficiency) and larger insulin-positive islet areas to administration of a low dose of STZ than WT mice.	Streptozocin	171-174	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
20060809-7	2010	Moreover, administration of JTE-013, a S1P(2)-specific antagonist, to WT mice ameliorated STZ-induced blood glucose elevation and reduced the incidence of diabetes.	JTE 013	28-35	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
20060809-7	2010	Moreover, administration of JTE-013, a S1P(2)-specific antagonist, to WT mice ameliorated STZ-induced blood glucose elevation and reduced the incidence of diabetes.	Streptozocin	90-93	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
20060809-8	2010	Our findings indicate that blockade of S1P(2) signaling attenuates STZ-induced apoptosis of pancreatic beta-cells and decreases the incidence of diabetes.	Streptozocin	67-70	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
19603543-3	2009	We report here that mutant mice engineered to selectively lack S1P in plasma displayed increased vascular leak and impaired survival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and exposure to related inflammatory challenges.	Histamine	206-215	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
19618460-5	2009	One potential immune modulating compound, sphingosine-1-phosphate (S1P), was recently highlighted in both tumor growth and immune modulation.	sphingosine 1-phosphate	42-65	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
19228106-1	2009	Recent evidence suggests that sphingosine 1-phosphate (S1P) regulates self-renewal of human embryonic stem (ES) cells and differentiation of mouse embryoid bodies (derived from mouse ES cells) to cardiomyocytes.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
19228106-6	2009	The treatment of ES cells with phytosphingosine 1-phosphate (phyto-S1P), which we show here is an agonist of the S1P(5) receptor, stimulated ERK-1/2 activation.	Einsteinium	17-19	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
19228106-6	2009	The treatment of ES cells with phytosphingosine 1-phosphate (phyto-S1P), which we show here is an agonist of the S1P(5) receptor, stimulated ERK-1/2 activation.	Einsteinium	17-19	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
19228106-6	2009	The treatment of ES cells with phytosphingosine 1-phosphate (phyto-S1P), which we show here is an agonist of the S1P(5) receptor, stimulated ERK-1/2 activation.	phytosphingosine-1-phosphate	31-59	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
19228106-6	2009	The treatment of ES cells with phytosphingosine 1-phosphate (phyto-S1P), which we show here is an agonist of the S1P(5) receptor, stimulated ERK-1/2 activation.	phytosphingosine-1-phosphate	31-59	sphingosine-1-phosphate receptor 1	Mus musculus	113-116
19228106-8	2009	The S1P-dependent activation of ERK-1/2 was sensitive to inhibition by pertussis toxin (uncouples the G-protein, G(i) from GPCR), bisindolylmaleimide I (PKC inhibitor), and PP2 (c-Src inhibitor), but was not reduced by LY29004 (PI3K inhibitor) suggesting that S1P uses G(i)-, PKC-, and c-Src-dependent mechanisms to activate the ERK-1/2 pathway in ES cells.	bisindolylmaleimide I	130-151	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
19228106-8	2009	The S1P-dependent activation of ERK-1/2 was sensitive to inhibition by pertussis toxin (uncouples the G-protein, G(i) from GPCR), bisindolylmaleimide I (PKC inhibitor), and PP2 (c-Src inhibitor), but was not reduced by LY29004 (PI3K inhibitor) suggesting that S1P uses G(i)-, PKC-, and c-Src-dependent mechanisms to activate the ERK-1/2 pathway in ES cells.	ly29004	219-226	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
19608972-8	2009	Chelation of calcium does not affect the activation of RhoA by S1P, whereas blockade of Rho by C3 exotoxin partially inhibits the mobilization of calcium by S1P.	Calcium	146-153	sphingosine-1-phosphate receptor 1	Mus musculus	157-160
19608972-10	2009	We further conclude that transcriptional regulation of SMA by S1P in vitro requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular calcium stores.	Calcium	139-146	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
19608972-10	2009	We further conclude that transcriptional regulation of SMA by S1P in vitro requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular calcium stores.	Calcium	166-173	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
19596980-1	2009	Sphingosine kinase (SphK) phosphorylates sphingosine into sphingosine-1-phosphate (S1P).	Sphingosine	41-52	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
19596980-1	2009	Sphingosine kinase (SphK) phosphorylates sphingosine into sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	58-81	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
19489538-2	2009	S1PL catalyzes the irreversible decomposition of sphingosine-1-phosphate (S1P) by a retro-aldol fragmentation that yields hexadecanaldehyde and phosphoethanolamine.	hexadecanal	122-139	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
19489538-2	2009	S1PL catalyzes the irreversible decomposition of sphingosine-1-phosphate (S1P) by a retro-aldol fragmentation that yields hexadecanaldehyde and phosphoethanolamine.	phosphorylethanolamine	144-163	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
19489538-4	2009	Mechanistic studies of lymphoid tissue following oral administration of 2-acetyl-4(5)-(1(R),2(S),3(R),4-tetrahydroxybutyl)-imidazole (THI) 3 showed a clear relationship between reduced lyase activity, elevated S1P levels, and lower levels of circulating lymphocytes.	2-acetyl-4(5)-(1(r),2(s),3(r),4-tetrahydroxybutyl)-imidazole	72-132	sphingosine-1-phosphate receptor 1	Mus musculus	210-213
19874715-2	2009	Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration.	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
19874715-2	2009	Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration.	Sphingolipids	67-79	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
19608972-7	2009	S1P-stimulated SMA expression requires S1P2R-dependent activation of RhoA and mobilization of calcium from intracellular stores.	Calcium	94-101	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
19592667-2	2009	We previously demonstrated the potent barrier-enhancing effects of both sphingosine 1-phosphate (S1P) and the structurally similar compound FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] in inflammatory lung injury.	sphingosine 1-phosphate	72-95	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
19228708-3	2009	Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, regulates the function of numerous cell types.	Lysophospholipids	43-59	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
19433984-3	2009	S1P stimulation of ERK was completely inhibited by an S1P1/3 subtype receptor antagonist (VPC23019), by a Gi protein inhibitor (pertussis toxin) and by a mitogen-activated protein kinase/ERK kinase inhibitor (PD98059).	VPC23019	90-98	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
19433984-3	2009	S1P stimulation of ERK was completely inhibited by an S1P1/3 subtype receptor antagonist (VPC23019), by a Gi protein inhibitor (pertussis toxin) and by a mitogen-activated protein kinase/ERK kinase inhibitor (PD98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	209-216	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
19433984-5	2009	The selective S1P1 agonist SEW2871 also induced ERK phosphorylation.	SEW2871	27-34	sphingosine-1-phosphate receptor 1	Mus musculus	14-18
19017750-1	2009	Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury.	sphingosine 1-phosphate	33-56	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
19158154-1	2009	Anti-lymphocyte antibodies (Abs) that suppress T-cell chemotactic and other responses to sphingosine 1-phosphate (S1P), but not to chemokines, were found in a lymphopenic patient with recurrent infections.	sphingosine 1-phosphate	89-112	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
19158154-4	2009	Human purified anti-S1P(1) Abs decreased mouse blood lymphocyte levels by a mean of 72%, suppressed mouse T-cell chemotaxis to S1P in vivo, and significantly reduced the severity of dextran sodium sulfate-induced colitis in mice.	dextran sodium sulfate	182-204	sphingosine-1-phosphate receptor 1	Mus musculus	20-23
19234089-1	2009	The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P) pathway, known to determine the fate and growth of various cell types, can enhance cardiac myocyte survival in vitro and provide cardioprotection in acute ex vivo heart preparations.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
19282351-5	2009	In cardiac myocytes, the S1P1 receptor subtype is the predominant subtype expressed, and the activation of this receptor inhibits cAMP formation and antagonizes adrenergic receptor-mediated contractility.	Cyclic AMP	130-134	sphingosine-1-phosphate receptor 1	Mus musculus	25-29
19251691-2	2009	Based on earlier findings with the lyase-stable, semi-synthetic, cis-4-methylsphingosine phosphate, we hypothesized that accumulation of S1P above a certain threshold induces neuronal apoptosis.	cis-4-methylsphingosine phosphate	65-98	sphingosine-1-phosphate receptor 1	Mus musculus	137-140
19251691-4	2009	These conclusions are based on the finding that incubation of lyase-deficient neurons with either sphingosine or S1P results in a similar elevation in cellular S1P; however, only S1P addition to the culture medium induces apoptosis.	Sphingosine	98-109	sphingosine-1-phosphate receptor 1	Mus musculus	160-163
19251691-4	2009	These conclusions are based on the finding that incubation of lyase-deficient neurons with either sphingosine or S1P results in a similar elevation in cellular S1P; however, only S1P addition to the culture medium induces apoptosis.	Sphingosine	98-109	sphingosine-1-phosphate receptor 1	Mus musculus	160-163
19251691-6	2009	Although the cells produced S1P from both exogenously added sphingosine as well as sphingosine derived from exogenous S1P, the S1P from these two sources were not equivalent, because the former was primarily produced by SK1, whereas the latter was mainly formed by SK2 (as also was cis-4-methylsphingosine phosphate), based on studies in neurons lacking SK1 or SK2 activity.	Sphingosine	83-94	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
19251691-6	2009	Although the cells produced S1P from both exogenously added sphingosine as well as sphingosine derived from exogenous S1P, the S1P from these two sources were not equivalent, because the former was primarily produced by SK1, whereas the latter was mainly formed by SK2 (as also was cis-4-methylsphingosine phosphate), based on studies in neurons lacking SK1 or SK2 activity.	Sphingosine	83-94	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
19251691-8	2009	In this model, S1P accumulated due to a defective lyase, however, this cause of toxicity might also be important in other cases, as illustrated by the neurotoxicity of cis-4-methylsphingosine phosphate.	cis-4-methylsphingosine phosphate	168-201	sphingosine-1-phosphate receptor 1	Mus musculus	15-18
19234089-9	2009	The S1P(1)-specific agonism with oral SEW2871 during the first 2-wk after MI reduced apoptosis in the RM and resulted in improved myocardial function, as reflected in the echocardiographic measurement of fractional shortening.	SEW2871	38-45	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
19234089-9	2009	The S1P(1)-specific agonism with oral SEW2871 during the first 2-wk after MI reduced apoptosis in the RM and resulted in improved myocardial function, as reflected in the echocardiographic measurement of fractional shortening.	Inositol	74-76	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
19285924-1	2009	Sphingosine-1-phosphate (S1P) is an important sphingolipid signaling molecule that regulates numerous cellular processes.	Sphingolipids	46-58	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
19285924-2	2009	In this paper we report a new method to quantify the levels of S1P in biological samples that relies on derivatization with naphthalene-2,3-dicarboxaldehyde (NDA) and quantification by reverse-phase high performance liquid chromatography (HPLC).	2,3-naphthalenedicarboxaldehyde	124-156	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
19285924-2	2009	In this paper we report a new method to quantify the levels of S1P in biological samples that relies on derivatization with naphthalene-2,3-dicarboxaldehyde (NDA) and quantification by reverse-phase high performance liquid chromatography (HPLC).	2,3-naphthalenedicarboxaldehyde	158-161	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
19150609-0	2009	Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog.	sphingosine 1-phosphate	15-38	sphingosine-1-phosphate receptor 1	Mus musculus	86-90
19150609-0	2009	Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog.	sphingosine 1-phosphate	109-132	sphingosine-1-phosphate receptor 1	Mus musculus	86-90
19150609-1	2009	Chemical lead 2 (CL2) is the first non-sphingosine-1-phosphate (Sph-1-P) analog type antagonist of endothelial differentiation gene-1 (Edg-1/S1P(1)), which is a member of the Sph-1-P receptor family.	Chlorine	17-20	sphingosine-1-phosphate receptor 1	Mus musculus	135-140
19150609-1	2009	Chemical lead 2 (CL2) is the first non-sphingosine-1-phosphate (Sph-1-P) analog type antagonist of endothelial differentiation gene-1 (Edg-1/S1P(1)), which is a member of the Sph-1-P receptor family.	sphingosine 1-phosphate	39-62	sphingosine-1-phosphate receptor 1	Mus musculus	135-140
19150609-1	2009	Chemical lead 2 (CL2) is the first non-sphingosine-1-phosphate (Sph-1-P) analog type antagonist of endothelial differentiation gene-1 (Edg-1/S1P(1)), which is a member of the Sph-1-P receptor family.	sph-1-p	64-71	sphingosine-1-phosphate receptor 1	Mus musculus	135-140
18955732-1	2009	Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P(2)) in hepatocytes in rats in vitro.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
19204730-6	2009	Intravital two-photon imaging of bone tissues showed that a potent S1P(1) agonist, SEW2871, stimulated motility of osteoclast precursor-containing monocytoid populations in vivo.	SEW2871	83-90	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
18955732-1	2009	Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P(2)) in hepatocytes in rats in vitro.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	211-214
18955732-3	2009	Nuclear 5-bromo-2"-deoxy-uridine labeling, proliferating cell nuclear antigen (PCNA) staining in hepatocytes, and the ratio of liver weight to body weight were enhanced at 48 h in S1P(2)-deficient mice after a single carbon tetrachloride (CCl(4)) injection.	Bromodeoxyuridine	8-32	sphingosine-1-phosphate receptor 1	Mus musculus	180-183
18955732-3	2009	Nuclear 5-bromo-2"-deoxy-uridine labeling, proliferating cell nuclear antigen (PCNA) staining in hepatocytes, and the ratio of liver weight to body weight were enhanced at 48 h in S1P(2)-deficient mice after a single carbon tetrachloride (CCl(4)) injection.	Carbon Tetrachloride	217-237	sphingosine-1-phosphate receptor 1	Mus musculus	180-183
18955732-3	2009	Nuclear 5-bromo-2"-deoxy-uridine labeling, proliferating cell nuclear antigen (PCNA) staining in hepatocytes, and the ratio of liver weight to body weight were enhanced at 48 h in S1P(2)-deficient mice after a single carbon tetrachloride (CCl(4)) injection.	Cefaclor	239-242	sphingosine-1-phosphate receptor 1	Mus musculus	180-183
18955732-4	2009	After dimethylnitrosamine (DMN) administration with a lethal dose, PCNA staining in hepatocytes was enhanced at 48 h and survival rate was higher in S1P(2)-deficient mice.	Dimethylnitrosamine	6-25	sphingosine-1-phosphate receptor 1	Mus musculus	149-152
18955732-4	2009	After dimethylnitrosamine (DMN) administration with a lethal dose, PCNA staining in hepatocytes was enhanced at 48 h and survival rate was higher in S1P(2)-deficient mice.	Dimethylnitrosamine	27-30	sphingosine-1-phosphate receptor 1	Mus musculus	149-152
18955732-6	2009	After chronic CCl(4) administration, fibrosis was less apparent, with reduced expression of smooth-muscle alpha-actin-positive cells in the livers of S1P(2)-deficient mice, suggesting that S1P(2) inactivation ameliorated CCl(4)-induced fibrosis due to the decreased accumulation of hepatic stellate cells.	Cefaclor	14-17	sphingosine-1-phosphate receptor 1	Mus musculus	150-153
18955732-6	2009	After chronic CCl(4) administration, fibrosis was less apparent, with reduced expression of smooth-muscle alpha-actin-positive cells in the livers of S1P(2)-deficient mice, suggesting that S1P(2) inactivation ameliorated CCl(4)-induced fibrosis due to the decreased accumulation of hepatic stellate cells.	Cefaclor	14-17	sphingosine-1-phosphate receptor 1	Mus musculus	189-192
18955732-6	2009	After chronic CCl(4) administration, fibrosis was less apparent, with reduced expression of smooth-muscle alpha-actin-positive cells in the livers of S1P(2)-deficient mice, suggesting that S1P(2) inactivation ameliorated CCl(4)-induced fibrosis due to the decreased accumulation of hepatic stellate cells.	Cefaclor	221-224	sphingosine-1-phosphate receptor 1	Mus musculus	189-192
19276615-1	2009	Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
19276615-1	2009	Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death.	Ceramides	35-43	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
19276615-1	2009	Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death.	Arachidonic Acid	183-199	sphingosine-1-phosphate receptor 1	Mus musculus	118-121
19091959-9	2009	Incubation of diabetic NOD EC with S1P and the S1P(1)-selective agonist SEW2871 significantly increased expression of MKP-3 and reduced ERK1/2 phosphorylation, while incubation with the S1P(1)/S1P(3) antagonist VPC23019 decreased the expression of MKP-3, both results supporting a role for S1P(1) in MKP-3 regulation.	SEW2871	72-79	sphingosine-1-phosphate receptor 1	Mus musculus	47-53
19091959-9	2009	Incubation of diabetic NOD EC with S1P and the S1P(1)-selective agonist SEW2871 significantly increased expression of MKP-3 and reduced ERK1/2 phosphorylation, while incubation with the S1P(1)/S1P(3) antagonist VPC23019 decreased the expression of MKP-3, both results supporting a role for S1P(1) in MKP-3 regulation.	SEW2871	72-79	sphingosine-1-phosphate receptor 1	Mus musculus	186-192
19091959-9	2009	Incubation of diabetic NOD EC with S1P and the S1P(1)-selective agonist SEW2871 significantly increased expression of MKP-3 and reduced ERK1/2 phosphorylation, while incubation with the S1P(1)/S1P(3) antagonist VPC23019 decreased the expression of MKP-3, both results supporting a role for S1P(1) in MKP-3 regulation.	SEW2871	72-79	sphingosine-1-phosphate receptor 1	Mus musculus	186-192
18805787-5	2008	Intrathecal application of S1P or sphinganine 1-phosphate (dihydro-S1P) reduced the pain-related (nociceptive) behavior in the formalin assay.	dihydrosphingosine 1-phosphate	34-57	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
18824518-1	2009	Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) and is a critical regulator of sphingolipid-mediated functions.	Sphingosine	44-55	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
18824518-1	2009	Sphingosine kinase 1 (SphK1) phosphorylates sphingosine to form sphingosine-1-phosphate (S1P) and is a critical regulator of sphingolipid-mediated functions.	Sphingolipids	125-137	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
18824518-3	2009	Also, our previous studies implicated the SphK1/S1P pathway in the induction of the arachidonic acid cascade, a major inflammatory pathway involved in colon carcinogenesis.	Arachidonic Acid	84-100	sphingosine-1-phosphate receptor 1	Mus musculus	48-51
18824518-7	2009	In the azoxymethane (AOM) murine model of colon cancer, SphK1 and S1P were significantly elevated in colon cancer tissues compared to normal mucosa.	Azoxymethane	7-19	sphingosine-1-phosphate receptor 1	Mus musculus	66-69
18757288-5	2008	Endogenous NPC migration toward the insult was evaluated after ventricular administration of the S1P(2)R antagonist JTE-013.	(2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid	116-119	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
19309565-1	2009	Sphingosine 1-phosphate (S1P) is a natural lysophospholipid able to enhance antimycobacterial innate immune response.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
19309565-1	2009	Sphingosine 1-phosphate (S1P) is a natural lysophospholipid able to enhance antimycobacterial innate immune response.	Lysophospholipids	43-59	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
19119317-1	2009	BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism.	sphingosine 1-phosphate	64-87	sphingosine-1-phosphate receptor 1	Mus musculus	12-15
19119317-1	2009	BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the terminal step of sphingolipid catabolism.	Sphingolipids	118-130	sphingosine-1-phosphate receptor 1	Mus musculus	12-15
19017993-1	2008	Sphingosine kinase (SphK) is a key enzyme in the sphingolipid metabolic pathway responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P).	Sphingolipids	49-61	sphingosine-1-phosphate receptor 1	Mus musculus	154-157
19017993-1	2008	Sphingosine kinase (SphK) is a key enzyme in the sphingolipid metabolic pathway responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P).	Sphingosine	112-123	sphingosine-1-phosphate receptor 1	Mus musculus	154-157
19017993-1	2008	Sphingosine kinase (SphK) is a key enzyme in the sphingolipid metabolic pathway responsible for phosphorylating sphingosine into sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	129-152	sphingosine-1-phosphate receptor 1	Mus musculus	154-157
19017993-3	2008	Recently, S1P(1) receptor was found to be expressed in rheumatoid arthritis (RA) synovium, and S1P signaling via S1P(1) enhances synoviocyte proliferation, COX-2 expression, and prostaglandin E(2) production.	Prostaglandins E	178-193	sphingosine-1-phosphate receptor 1	Mus musculus	10-13
19017993-3	2008	Recently, S1P(1) receptor was found to be expressed in rheumatoid arthritis (RA) synovium, and S1P signaling via S1P(1) enhances synoviocyte proliferation, COX-2 expression, and prostaglandin E(2) production.	Prostaglandins E	178-193	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
19017993-3	2008	Recently, S1P(1) receptor was found to be expressed in rheumatoid arthritis (RA) synovium, and S1P signaling via S1P(1) enhances synoviocyte proliferation, COX-2 expression, and prostaglandin E(2) production.	Prostaglandins E	178-193	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
18393631-3	2008	We previously demonstrated that sphingosine-1-phosphate (S1P) plays an important role in survival and proliferation of hESCs.	sphingosine 1-phosphate	32-55	sphingosine-1-phosphate receptor 1	Mus musculus	57-60
18805787-5	2008	Intrathecal application of S1P or sphinganine 1-phosphate (dihydro-S1P) reduced the pain-related (nociceptive) behavior in the formalin assay.	Formaldehyde	127-135	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
18805787-5	2008	Intrathecal application of S1P or sphinganine 1-phosphate (dihydro-S1P) reduced the pain-related (nociceptive) behavior in the formalin assay.	Formaldehyde	127-135	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
18805787-6	2008	S1P and dihydro-S1P inhibited cyclic AMP (cAMP) synthesis, a key second messenger of spinal nociceptive processing, in spinal cord neurons.	Cyclic AMP	30-40	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18805787-6	2008	S1P and dihydro-S1P inhibited cyclic AMP (cAMP) synthesis, a key second messenger of spinal nociceptive processing, in spinal cord neurons.	Cyclic AMP	30-40	sphingosine-1-phosphate receptor 1	Mus musculus	16-19
18805787-6	2008	S1P and dihydro-S1P inhibited cyclic AMP (cAMP) synthesis, a key second messenger of spinal nociceptive processing, in spinal cord neurons.	Cyclic AMP	42-46	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18805787-6	2008	S1P and dihydro-S1P inhibited cyclic AMP (cAMP) synthesis, a key second messenger of spinal nociceptive processing, in spinal cord neurons.	Cyclic AMP	42-46	sphingosine-1-phosphate receptor 1	Mus musculus	16-19
18805787-7	2008	By combining fluorescence resonance energy transfer (FRET)-based cAMP measurements with Multi Epitope Ligand Cartography (MELC), we showed that S1P decreased cAMP synthesis in excitatory dorsal horn neurons.	Cyclic AMP	65-69	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
18805787-7	2008	By combining fluorescence resonance energy transfer (FRET)-based cAMP measurements with Multi Epitope Ligand Cartography (MELC), we showed that S1P decreased cAMP synthesis in excitatory dorsal horn neurons.	Cyclic AMP	158-162	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
18805787-8	2008	Accordingly, intrathecal application of dihydro-S1P abolished the cAMP-dependent phosphorylation of NMDA receptors in the outer laminae of the spinal cord.	Cyclic AMP	66-70	sphingosine-1-phosphate receptor 1	Mus musculus	48-51
18805787-9	2008	Taken together, the data show that S1P modulates spinal nociceptive processing through inhibition of neuronal cAMP synthesis.	Cyclic AMP	110-114	sphingosine-1-phosphate receptor 1	Mus musculus	35-38
18849324-1	2008	The lipid mediator sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SPHK)-induced phosphorylation of sphingosine, is known to stabilize interendothelial junctions and prevent microvessel leakiness.	Sphingosine	19-30	sphingosine-1-phosphate receptor 1	Mus musculus	44-47
18172856-0	2008	S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.	sphingosine 1-phosphate	49-72	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	zwitterionic	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	zwitterionic	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Phosphates	56-65	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Phosphates	56-65	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Amines	70-75	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Amines	70-75	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	sphingosine 1-phosphate	86-109	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	sphingosine 1-phosphate	86-109	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Arginine	129-132	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Arginine	129-132	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Glutamic Acid	137-140	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Glutamic Acid	137-140	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
18703638-8	2008	S1P produced dose-dependent increase in COX-2 expression, resulting in increased PGE(2) release from SEMFs.	Dinoprostone	81-87	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18385762-1	2008	Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, regulates multiple cellular responses such as Ca(2+) signaling, growth, survival, and differentiation.	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
18359884-1	2008	Sphingosine 1-phosphate (S1P) produced by sphingosine kinase (SPHK) is implicated in acute immunoresponses, however, mechanisms of SPHK/S1P signaling in the pathogenesis of bronchial asthma are poorly understood.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
18359884-1	2008	Sphingosine 1-phosphate (S1P) produced by sphingosine kinase (SPHK) is implicated in acute immunoresponses, however, mechanisms of SPHK/S1P signaling in the pathogenesis of bronchial asthma are poorly understood.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	136-139
18359884-7	2008	DMS or SK-I inhalation resulted in a decrease in S1P amounts in BAL fluid to basal levels, accompanied by decreased eosinophil infiltration and peroxidase activity.	N,N-dimethylsphingosine	0-3	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
18359884-7	2008	DMS or SK-I inhalation resulted in a decrease in S1P amounts in BAL fluid to basal levels, accompanied by decreased eosinophil infiltration and peroxidase activity.	sk-i	7-11	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
18172856-1	2008	Sphingosine 1-phosphate (S1P) is the natural ligand for a specific family of G protein-coupled receptors (-Rs).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
18172856-4	2008	Clearance of S1P, but not sphingosine (Sph) was inhibited with the protein phosphatase inhibitor sodium orthovanadate.	Sodium orthovanadate	97-117	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
18172856-5	2008	Fluorescence microscopy and flow cytometry using fluorescently labeled S1P and Sph showed a major cellular uptake of Sph, but not S1P.	Sphingosine	117-120	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
18172856-7	2008	Sub cellular fractionation resulted in dephosphorylation of S1P to Sph by nuclear, membrane, and cytosolic fractions.	Sphingosine	67-70	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
18178871-1	2008	Sphingosine-1-phosphate (S1P) is now emerging as a potent lipid mediator produced by mast cells that contributes to inflammatory and allergic responses.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
18187460-1	2008	AIMS: The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration, proliferation, and capillary-like tube formation in vitro.	Lysophospholipids	10-26	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
18026125-1	2008	BACKGROUND AND PURPOSE: Sphingosine 1-phosphate (S1P) selectively and potently constricts isolated cerebral arteries, but this response has not been pharmacologically characterized.	sphingosine 1-phosphate	24-47	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
18058233-1	2008	A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).	Sphingolipids	91-103	sphingosine-1-phosphate receptor 1	Mus musculus	245-248
18058233-1	2008	A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	220-243	sphingosine-1-phosphate receptor 1	Mus musculus	245-248
18058233-9	2008	S1P levels were also elevated in the DSS group and significantly reduced by drug treatment.	Dextran Sulfate	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18024550-4	2008	S1P(1) was shown to be involved by using the S1P(1)-selective agonist SEW2871 on myocytes isolated from S1P(3)-null mice.	SEW2871	70-77	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
18024550-4	2008	S1P(1) was shown to be involved by using the S1P(1)-selective agonist SEW2871 on myocytes isolated from S1P(3)-null mice.	SEW2871	70-77	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
18024550-4	2008	S1P(1) was shown to be involved by using the S1P(1)-selective agonist SEW2871 on myocytes isolated from S1P(3)-null mice.	SEW2871	70-77	sphingosine-1-phosphate receptor 1	Mus musculus	45-48
18024550-7	2008	Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits).	Acetylcholine	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	139-142
18024550-7	2008	Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits).	Acetylcholine	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	157-160
18024550-8	2008	Mathematical modeling of the effects of S1P on APD in the mouse ventricle suggests that shortening of APD (e.g., as induced by I(K(ACh))) can reduce L-type calcium current and thus can decrease the intracellular Ca(2+) concentration ([Ca(2+)](i)) transient.	Acetylcholine	131-134	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
18024550-8	2008	Mathematical modeling of the effects of S1P on APD in the mouse ventricle suggests that shortening of APD (e.g., as induced by I(K(ACh))) can reduce L-type calcium current and thus can decrease the intracellular Ca(2+) concentration ([Ca(2+)](i)) transient.	Calcium	156-163	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
18024550-10	2008	In summary, these findings suggest that the negative inotropy observed in S1P-treated adult mouse ventricular myocytes may consist of two distinctive components: 1) one pathway that acts via G(i) to reduce L-type calcium channel current, blunt calcium-induced calcium release, and decrease [Ca(2+)](i); and 2) a second pathway that acts via G(i) to activate I(K(ACh)) and reduce APD.	Calcium	213-220	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
18024550-10	2008	In summary, these findings suggest that the negative inotropy observed in S1P-treated adult mouse ventricular myocytes may consist of two distinctive components: 1) one pathway that acts via G(i) to reduce L-type calcium channel current, blunt calcium-induced calcium release, and decrease [Ca(2+)](i); and 2) a second pathway that acts via G(i) to activate I(K(ACh)) and reduce APD.	Calcium	244-251	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
18024550-10	2008	In summary, these findings suggest that the negative inotropy observed in S1P-treated adult mouse ventricular myocytes may consist of two distinctive components: 1) one pathway that acts via G(i) to reduce L-type calcium channel current, blunt calcium-induced calcium release, and decrease [Ca(2+)](i); and 2) a second pathway that acts via G(i) to activate I(K(ACh)) and reduce APD.	Acetylcholine	362-365	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
18178864-11	2008	Our data underscore the importance of S1P in AC-mediated immune regulation, by stabilizing COX-2 mRNA in macrophages, a prerequisite for PGE2 formation.	Dinoprostone	137-141	sphingosine-1-phosphate receptor 1	Mus musculus	38-41
18258856-1	2008	Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
18258856-1	2008	Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	119-122
18026195-9	2008	Sphingolipid profiles in tumour tissue also showed increased levels of S1P.	Sphingolipids	0-12	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
18026125-6	2008	JTE-013 inhibited not only S1P-induced vasoconstriction, but also KCl-, U46619- and endothelin-1-induced constriction.	JTE 013	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
18026125-11	2008	The purported S1P(2) receptor antagonist JTE-013 does not appear to be selective, at least in rodents.	JTE 013	41-48	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
17931360-1	2007	Sphingosine 1-phosphate (S1P) is accumulated in lipoproteins, especially high-density lipoprotein (HDL), in plasma.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17898040-3	2007	We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.	Isoflurane	31-41	sphingosine-1-phosphate receptor 1	Mus musculus	128-131
17898040-3	2007	We sought to determine whether isoflurane stimulates sphingosine kinase (SK) activity and synthesis of sphingosine-1-phosphate (S1P) in renal proximal tubule cells to mediate renal protection via the S1P signaling pathway.	Isoflurane	31-41	sphingosine-1-phosphate receptor 1	Mus musculus	200-203
17898040-5	2007	This protection with isoflurane was reversed by SK inhibitors (DMS and SKI-II) as well as an S1P(1) receptor antagonist (VPC23019).	Isoflurane	21-31	sphingosine-1-phosphate receptor 1	Mus musculus	93-96
17898040-5	2007	This protection with isoflurane was reversed by SK inhibitors (DMS and SKI-II) as well as an S1P(1) receptor antagonist (VPC23019).	VPC23019	121-129	sphingosine-1-phosphate receptor 1	Mus musculus	93-96
17898040-8	2007	Finally, isoflurane increased the generation of S1P in HK-2 cells.	Isoflurane	9-19	sphingosine-1-phosphate receptor 1	Mus musculus	48-51
17898040-9	2007	Taken together, our findings indicate that isoflurane activates SK in renal tubule cells and initiates S1P--&gt;S1P(1) receptor signaling to mediate the renal protective effects.	Isoflurane	43-53	sphingosine-1-phosphate receptor 1	Mus musculus	103-106
17898040-9	2007	Taken together, our findings indicate that isoflurane activates SK in renal tubule cells and initiates S1P--&gt;S1P(1) receptor signaling to mediate the renal protective effects.	Isoflurane	43-53	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
17965716-3	2007	The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P1, regulates the recirculation of T and B lymphocytes.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	79-83
17965716-3	2007	The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P1, regulates the recirculation of T and B lymphocytes.	sphingosine 1-phosphate	21-44	sphingosine-1-phosphate receptor 1	Mus musculus	79-83
17931360-3	2007	The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and HDL-like lipoprotein formation, stimulated extracellular S1P accumulation in the presence of its precursor sphingosine.	Tretinoin	37-50	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
17931360-3	2007	The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and HDL-like lipoprotein formation, stimulated extracellular S1P accumulation in the presence of its precursor sphingosine.	Bucladesine	55-69	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
17931360-3	2007	The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP, which induce apolipoprotein E (apoE) synthesis and HDL-like lipoprotein formation, stimulated extracellular S1P accumulation in the presence of its precursor sphingosine.	Sphingosine	229-240	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
17931360-5	2007	S1P release from astrocytes was inhibited by the treatment of the cells with glybenclamide or small interfering RNAs specific to ATP-binding cassette transporter A1 (ABCA1).	Glyburide	77-90	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
17931360-6	2007	Astrocytes from Abca1-/- mice also showed impairment of retinoic acid/dibutyryl cAMP-induced S1P release in association with the blockage of HDL-like lipoprotein formation.	Cyclic AMP	80-84	sphingosine-1-phosphate receptor 1	Mus musculus	93-96
17610857-1	2007	OBJECTIVE: Sphingosine kinase (SphK) is a key enzyme in the synthesis of sphingosine 1-phosphate (S1P), a bioactive sphingolipid.	sphingosine 1-phosphate	73-96	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
17577630-5	2007	One of the protein kinase C (PKC) inhibitors, Go6976, suppressed the LPA- and S1P-stimulated NGF synthesis by 70 and 80%, respectively.	Go 6976	46-52	sphingosine-1-phosphate receptor 1	Mus musculus	78-81
17709403-2	2007	In particular, bioactive lipids such as sphingosine-1-phosphate (S1P) bind to cognate G protein-coupled receptors (GPCRs) and modulate leukocyte trafficking and homeostasis.	sphingosine 1-phosphate	40-63	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
17991617-1	2007	Sphingosine 1-phosphate (S1P), a lysophospholipid mediator that signals through G protein-coupled receptors, regulates a wide plethora of biological responses such as angiogenesis and immune cell trafficking.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17991617-1	2007	Sphingosine 1-phosphate (S1P), a lysophospholipid mediator that signals through G protein-coupled receptors, regulates a wide plethora of biological responses such as angiogenesis and immune cell trafficking.	Lysophospholipids	33-49	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17991617-3	2007	In this report, we describe a new method to selectively enrich S1P and dihydro-S1P from biological samples by the Fe(3+) gel immobilized metal affinity chromatography (IMAC).	ferric sulfate	114-120	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
17991617-3	2007	In this report, we describe a new method to selectively enrich S1P and dihydro-S1P from biological samples by the Fe(3+) gel immobilized metal affinity chromatography (IMAC).	ferric sulfate	114-120	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
17991617-4	2007	The eluted S1P from IMAC was dephosphorylated, derivatized with o-phthalaldehyde (OPA), and detected by high-performance liquid chromatography (HPLC) coupled to a fluorescence detector.	imidazoleacetic acid	20-24	sphingosine-1-phosphate receptor 1	Mus musculus	11-14
17991617-4	2007	The eluted S1P from IMAC was dephosphorylated, derivatized with o-phthalaldehyde (OPA), and detected by high-performance liquid chromatography (HPLC) coupled to a fluorescence detector.	o-Phthalaldehyde	64-80	sphingosine-1-phosphate receptor 1	Mus musculus	11-14
17991617-7	2007	We also show that dihydro-S1P was the major sphingoid base phosphate secreted from HUVEC over expressed with Sphk1 cDNA.	sphingoid base phosphate	44-68	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
17991617-8	2007	Pharmcological antagonists of ABC transporters, glyburide and MK-571 attenuated endogenous S1P release.	Glyburide	48-57	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
17991617-8	2007	Pharmcological antagonists of ABC transporters, glyburide and MK-571 attenuated endogenous S1P release.	verlukast	62-68	sphingosine-1-phosphate receptor 1	Mus musculus	91-94
17991617-10	2007	IMAC-based affinity-enrichment coupled with a HPLC-based separation and detection system is a rapid and sensitive method to accurately quantify S1P.	imidazoleacetic acid	0-4	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
17610857-1	2007	OBJECTIVE: Sphingosine kinase (SphK) is a key enzyme in the synthesis of sphingosine 1-phosphate (S1P), a bioactive sphingolipid.	Sphingolipids	116-128	sphingosine-1-phosphate receptor 1	Mus musculus	98-101
17337593-9	2007	Lowering FBS concentrations from 10% to 0.1% increased S1P(2), whereas supplementation with either PDGF-BB or Rho-associated protein kinase inhibitor Y-27632 significantly elevated S1P(3) levels.	Y 27632	150-157	sphingosine-1-phosphate receptor 1	Mus musculus	181-184
17643267-1	2007	BACKGROUND: Blood platelets store sphingosine 1-phosphate (S1P) abundantly and release this bioactive lipid extracellularly.	sphingosine 1-phosphate	34-57	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
17341687-1	2007	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid produced by sphingosine kinase (SphK1 and 2).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17341687-1	2007	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid produced by sphingosine kinase (SphK1 and 2).	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17293497-1	2007	Sphingosine 1-phosphate (S1P) is released at sites of tissue injury and effects cellular responses through activation of G protein-coupled receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17307336-1	2007	Lysophosphatidic acid (LPA) stimulates sphingosine-1-phosphate (S1P)-sensitive motility in NIH3T3 clone7 cells.	lysophosphatidic acid	0-21	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
17307336-1	2007	Lysophosphatidic acid (LPA) stimulates sphingosine-1-phosphate (S1P)-sensitive motility in NIH3T3 clone7 cells.	lysophosphatidic acid	23-26	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
17307336-1	2007	Lysophosphatidic acid (LPA) stimulates sphingosine-1-phosphate (S1P)-sensitive motility in NIH3T3 clone7 cells.	sphingosine 1-phosphate	39-62	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
17442922-1	2007	Sphingosine 1-phosphate (S1P) in blood and lymph controls T cell traffic and proliferation through type 1 S1P receptor (S1P(1)) signals, but suppression of IFN-gamma generation has been the only consistently observed effect on T cell cytokines.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17322125-5	2007	We found that S1P administration on nonsensitized mouse bronchi does not cause any direct effect on bronchial tone, while a significant increase in Ach-induced contraction occurs after S1P challenge.	Acetylcholine	148-151	sphingosine-1-phosphate receptor 1	Mus musculus	185-188
17442922-1	2007	Sphingosine 1-phosphate (S1P) in blood and lymph controls T cell traffic and proliferation through type 1 S1P receptor (S1P(1)) signals, but suppression of IFN-gamma generation has been the only consistently observed effect on T cell cytokines.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	106-109
17442922-1	2007	Sphingosine 1-phosphate (S1P) in blood and lymph controls T cell traffic and proliferation through type 1 S1P receptor (S1P(1)) signals, but suppression of IFN-gamma generation has been the only consistently observed effect on T cell cytokines.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	120-126
17320845-11	2007	CONCLUSION: As the effect of GM-1 is blocked both at the receptor and the G-protein (Gi) levels, we conclude that S1P generated by GM-1 treatment must be exported from the cell and acts in a paracrine or autocrine manner to couple with its cognate receptor.	G(M1) Ganglioside	29-33	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
17337447-9	2007	In addition, TCDD exposure alters the expression of several factors comprising the KLF2 regulon, including Edg1/S1P(1), beta(7) integrin, CD52, Cdkn2d (cyclin-dependent kinase inhibitor 2D), s100a4, and IL10R alpha.	Polychlorinated Dibenzodioxins	13-17	sphingosine-1-phosphate receptor 1	Mus musculus	107-111
17331465-1	2007	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid (LPL) ligand that binds endothelial differentiation gene (Edg) family G-protein-coupled receptors and has been implicated as an important regulator in endothelial cells during inflammation processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17331465-1	2007	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid (LPL) ligand that binds endothelial differentiation gene (Edg) family G-protein-coupled receptors and has been implicated as an important regulator in endothelial cells during inflammation processes.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17331465-1	2007	Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid (LPL) ligand that binds endothelial differentiation gene (Edg) family G-protein-coupled receptors and has been implicated as an important regulator in endothelial cells during inflammation processes.	Lysophospholipids	63-66	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17404269-1	2007	Sphingosine 1-phosphate (S1P) is a natural lipid mediator that regulates immune cell traffic, Ab production, and T cell cytokine generation by mechanisms that enhance Th2 activities.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17320845-1	2007	OBJECTIVES: Activation of sphingosine kinase (SphK), which has two known isoforms, is responsible for the synthesis of sphingosine 1-phosphate (S1P), a cell survival factor.	sphingosine 1-phosphate	119-142	sphingosine-1-phosphate receptor 1	Mus musculus	144-147
17215483-1	2007	The blood constituent sphingosine 1-phosphate (S1P) is a specific ligand for five G-protein-coupled receptors designated S1P(1-5).	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	monoganglioside	153-168	sphingosine-1-phosphate receptor 1	Mus musculus	268-271
17320845-2	2007	We tested the following hypotheses: 1] cardiac myocytes null for the SphK1 gene are more vulnerable to the stress of hypoxia+glucose deprivation; 2] the monoganglioside GM-1, which activates SphK via protein kinase C epsilon, is ineffective in SphK1-null myocytes; 3] S1P generated by SphK activation requires cellular export to be cardioprotective.	G(M1) Ganglioside	169-173	sphingosine-1-phosphate receptor 1	Mus musculus	268-271
17320845-10	2007	In wildtype cells, enhanced survival produced by GM-1 was abrogated by pretreatment either with 300 nM of the S1P(1) receptor-selective antagonist VPC23019 or with 100 ng/ml of pertussis toxin for 16 h before exposure to hypoxia+glucose deprivation.	G(M1) Ganglioside	49-53	sphingosine-1-phosphate receptor 1	Mus musculus	110-113
17215483-1	2007	The blood constituent sphingosine 1-phosphate (S1P) is a specific ligand for five G-protein-coupled receptors designated S1P(1-5).	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	121-124
17339438-0	2007	Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.	sphingosine 1-phosphate	52-75	sphingosine-1-phosphate receptor 1	Mus musculus	77-80
17449940-1	2007	The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects.	Sphingolipids	14-26	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
17449940-7	2007	Interestingly, the ERK pathway inhibitor, UO126, reversed the apoptotic effects of S1P on B16 melanoma cells.	U 0126	42-47	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
17339438-8	2007	S1P at 10-1000 nM induced a marked migration and significantly enhanced the endocytosis of FITC-dextran in mature but not immature DCs.	fluorescein isothiocyanate dextran	91-103	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
17339438-0	2007	Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.	sphingosine 1-phosphate	52-75	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
17339438-9	2007	Pretreatment with (S)-FTY720-P at 0.1 microM or higher resulted in a significant inhibition of S1P-induced migration and endocytosis in mature DCs, whereas SEW2871 up to 100 microM did not show any clear effect.	FTY 720P	18-30	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
17339438-0	2007	Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.	sphingosine 1-phosphate	52-75	sphingosine-1-phosphate receptor 1	Mus musculus	126-129
17339438-1	2007	Dendritic cells (DCs) and lymphocytes are known to show a migratory response to the phospholipid mediator, sphingosine 1-phosphate (S1P).	Phospholipids	84-96	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
17339438-1	2007	Dendritic cells (DCs) and lymphocytes are known to show a migratory response to the phospholipid mediator, sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	107-130	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
17339438-4	2007	A potent S1P receptor agonist, the (S)-enantiomer of FTY720-phosphate [(S)-FTY720-P], at 0.1 nM or higher and a selective S1P receptor type 1 (S1P(1)) agonist, SEW2871, at 0.1 muM or higher induced a dose-dependent down-regulation of S1P(1).	FTY 720P	53-69	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
17098744-3	2007	Sphingosine 1-phosphate (S1P), a sphingolipid released from activated platelets, stimulates COX-2 induction and activates G-protein-coupled receptors coupled to Galpha family members.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17361098-3	2007	An important sphingolipid metabolite is sphingosine-1-phosphate (S1P), which acts through G protein-coupled receptors present on mammalian cells, thereby stimulating cell proliferation, angiogenesis and inhibiting apoptosis.	Sphingolipids	13-25	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
17361098-3	2007	An important sphingolipid metabolite is sphingosine-1-phosphate (S1P), which acts through G protein-coupled receptors present on mammalian cells, thereby stimulating cell proliferation, angiogenesis and inhibiting apoptosis.	sphingosine 1-phosphate	40-63	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
17361098-5	2007	S1P is irreversibly degraded by S1P lyase (SPL), an enzyme that is highly expressed in enterocytes, where it is involved in metabolism of dietary sphingolipids.	Sphingolipids	146-159	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
17158356-5	2007	Of note, treatment of BMCs derived from S1P3-/- mice with S1P did not rescue blood flow recovery.	bmcs	22-26	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
17158356-10	2007	CONCLUSIONS: S1P agonists might serve as sensitizers of CXCR4-mediated signaling and may be applied in clinical progenitor cell therapy to improve EPC or BMC function in patients with coronary artery disease.	bmc	154-157	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
17242884-1	2007	Sphingosine kinases (SphKs) catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P).	Sphingosine	60-71	sphingosine-1-phosphate receptor 1	Mus musculus	100-103
17242884-2	2007	Together with other sphingolipid metabolizing enzymes, SphKs regulate the balance of the lipid mediators, ceramide, sphingosine, and S1P.	Sphingolipids	20-32	sphingosine-1-phosphate receptor 1	Mus musculus	133-136
17098744-3	2007	Sphingosine 1-phosphate (S1P), a sphingolipid released from activated platelets, stimulates COX-2 induction and activates G-protein-coupled receptors coupled to Galpha family members.	Sphingolipids	33-45	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17098744-12	2007	S1P injection induced COX-2 in the lungs and livers of mice and increased plasma prostaglandin E(2), and these effects were prevented by Galpha(12) deficiency.	Dinoprostone	81-99	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
17146975-1	2006	Activation of Sphingosine kinase (Sphk) increases a bioactive lipid, sphingosine 1-phosphate (S1P) and has been observed in a variety of cancer cells.	sphingosine 1-phosphate	69-92	sphingosine-1-phosphate receptor 1	Mus musculus	94-97
17242282-1	2007	BACKGROUND: Numerous in vitro studies suggest that sphingosine 1-phosphate (S1P), a bioactive lysosphingolipid associated with high-density lipoproteins, accounts at least partly for the potent antiinflammatory properties of high-density lipoprotein and, thereby, contributes to the antiatherogenic potential attributed to high-density lipoproteins.	Sphingolipids	94-110	sphingosine-1-phosphate receptor 1	Mus musculus	76-79
18039015-3	2007	One sphingomyelin derivate, sphingosine-1-phosphate (S1P), has attracted particular attention for its effect on epidermal cells, which differs from those on most other cell types.	Sphingomyelins	4-17	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
17023430-2	2006	We show here that not only the chemokines CXCL12 and CXCL13 but also the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) enhance adhesion of murine follicular and marginal zone B cells to ICAM-1 in vitro.	Lysophospholipids	73-90	sphingosine-1-phosphate receptor 1	Mus musculus	116-119
17023430-2	2006	We show here that not only the chemokines CXCL12 and CXCL13 but also the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) enhance adhesion of murine follicular and marginal zone B cells to ICAM-1 in vitro.	sphingosine 1-phosphate	91-114	sphingosine-1-phosphate receptor 1	Mus musculus	116-119
17023430-5	2006	We used G(12)/G(13)- or G(q)/G(11)-deficient B cells to study the role of these G-protein families in lysophospholipid-induced adhesion and found that the pro-adhesive effects of LPA and S1P are completely abrogated in G(12)/G(13)-deficient marginal zone B cells, reduced in G(12)/G(13)-deficient follicular B cells, and normal in G(q)/G(11)-deficient B cells.	Lysophospholipids	102-118	sphingosine-1-phosphate receptor 1	Mus musculus	187-190
17257496-1	2006	Sphingosine 1-phosphate (S1P), a pleiotropic lysophospholipid, regulates signal transduction pathway via G-protein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17257496-1	2006	Sphingosine 1-phosphate (S1P), a pleiotropic lysophospholipid, regulates signal transduction pathway via G-protein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	140-146
17257496-1	2006	Sphingosine 1-phosphate (S1P), a pleiotropic lysophospholipid, regulates signal transduction pathway via G-protein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
17257496-1	2006	Sphingosine 1-phosphate (S1P), a pleiotropic lysophospholipid, regulates signal transduction pathway via G-protein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes.	Lysophospholipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	140-146
17257496-5	2006	In D10.G4.1 and EL-4.IL-2 cells, S1P-induced migration was almost completely inhibited by pretreatment with pertussis toxin, Clostoridium difficile toxin B, and (S)-enantiomer of FTY720-phosphate, a potent agonist at S1P1 and S1P4.	FTY 720P	179-195	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
16980623-1	2006	Sphingosine kinase (Sphk) enzymes are important in intracellular sphingolipid metabolism as well as in the biosynthesis of sphingosine 1-phosphate (S1P), an extracellular lipid mediator.	sphingosine 1-phosphate	123-146	sphingosine-1-phosphate receptor 1	Mus musculus	148-151
16945494-1	2006	Sphingosine 1-phosphate (S1P) is an endogenous growth factor with potent effects on many different cell types.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
16623665-1	2006	Sphingosine 1-phosphate (S1P), produced by Sphks (sphingosine kinases), is a multifunctional lipid mediator that regulates immune cell trafficking and vascular development.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
16982942-6	2006	In vivo, HDL- and S1P-mediated cardioprotection was dependent on nitric oxide (NO) and the S1P3 lysophospholipid receptor, because it was abolished by pharmacological NO synthase inhibition and was completely absent in S1P3-deficient mice.	Nitric Oxide	65-77	sphingosine-1-phosphate receptor 1	Mus musculus	18-21
16960101-0	2006	Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	121-125
16960101-8	2006	The S1P1 receptor-specific agonist SEW2871 inhibited monocyte adhesion to diabetic aortas.	SEW2871	35-42	sphingosine-1-phosphate receptor 1	Mus musculus	4-8
16831409-1	2006	OBJECTIVE: N, N-Dimethylsphingosine (DMS) is recognized as an inhibitor of sphingosine kinase (SphK), a key enzyme responsible for the formation of sphingosine-1-phosphate (S1P).	N,N-dimethylsphingosine	11-35	sphingosine-1-phosphate receptor 1	Mus musculus	173-176
16831409-1	2006	OBJECTIVE: N, N-Dimethylsphingosine (DMS) is recognized as an inhibitor of sphingosine kinase (SphK), a key enzyme responsible for the formation of sphingosine-1-phosphate (S1P).	dms	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	173-176
16831409-1	2006	OBJECTIVE: N, N-Dimethylsphingosine (DMS) is recognized as an inhibitor of sphingosine kinase (SphK), a key enzyme responsible for the formation of sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	148-171	sphingosine-1-phosphate receptor 1	Mus musculus	173-176
16936207-6	2006	In contrast to the adipose tissue, plasma levels of total sphingomyelin, ceramide, sphingosine, and sphingosine 1-phosphate (S1P) were elevated in ob/ob mice.	sphingosine 1-phosphate	100-123	sphingosine-1-phosphate receptor 1	Mus musculus	125-128
16846788-6	2006	Secondly, inverse agonism of the S1P(1) receptor with SB649146 to eliminate the constitutive activity of the S1P(1) receptor reduced the PDGF-induced activation of p42/p44 MAPK in MEF.	sb649146	54-62	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
16632640-1	2006	Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the expense of proapoptotic ceramide.	Sphingolipids	40-52	sphingosine-1-phosphate receptor 1	Mus musculus	161-164
16632640-1	2006	Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the expense of proapoptotic ceramide.	sphingosine 1-phosphate	136-159	sphingosine-1-phosphate receptor 1	Mus musculus	161-164
16632640-1	2006	Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the expense of proapoptotic ceramide.	Ceramides	197-205	sphingosine-1-phosphate receptor 1	Mus musculus	161-164
16829954-1	2006	Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	165-169
16846788-6	2006	Secondly, inverse agonism of the S1P(1) receptor with SB649146 to eliminate the constitutive activity of the S1P(1) receptor reduced the PDGF-induced activation of p42/p44 MAPK in MEF.	sb649146	54-62	sphingosine-1-phosphate receptor 1	Mus musculus	109-112
16846788-7	2006	Thirdly, SB649146 inhibited the migration of MEF in response to the selective S1P(1) receptor agonist, SEW2871 or PDGF.	sb649146	9-17	sphingosine-1-phosphate receptor 1	Mus musculus	78-81
16314531-1	2005	Sphingosine-1-phosphate (S1P), an important sphingolipid metabolite, regulates diverse cellular processes, including cell survival, growth, and differentiation.	Sphingolipids	44-56	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
16631609-1	2006	Sphingosine 1-phosphate (S1P) is a ligand for S1P family receptors (S1P(1)-S1P(5)).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	68-74
16572108-0	2006	S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.	SEW2871	26-33	sphingosine-1-phosphate receptor 1	Mus musculus	0-5
16572108-2	2006	Sphingosine 1-phospate (S1P) maintains endothelial cell integrity and inhibits lymphocyte egress via the specific S1P(1) receptor, and may play a role in reducing ischemic renal injury.	sphingosine 1-phospate	0-22	sphingosine-1-phosphate receptor 1	Mus musculus	114-119
16572108-3	2006	We examined the protective effects of a newly identified S1P(1)-selective agonist, SEW2871, on mouse renal I/R injury.	SEW2871	83-90	sphingosine-1-phosphate receptor 1	Mus musculus	57-62
16553609-1	2006	Sphingosine-1-phosphate (S1P) is a potent and pleiotropic bioactive lysophospholipid mostly released by activated platelets that acts on its target cells through its own G protein-coupled receptors.	Lysophospholipids	68-84	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
16357178-3	2005	In vitro, docetaxel and camptothecin induced strong inhibition of SphK1 and elevation of the ceramide/S1P ratio only in cell lines sensitive to these drugs.	Docetaxel	10-19	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
16357178-3	2005	In vitro, docetaxel and camptothecin induced strong inhibition of SphK1 and elevation of the ceramide/S1P ratio only in cell lines sensitive to these drugs.	Camptothecin	24-36	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
16357178-7	2005	Docetaxel induced a stronger SphK1 inhibition and ceramide/S1P ratio elevation than camptothecin.	Docetaxel	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	59-62
16301618-3	2005	Although changes in circulating monocytes were not observed with overnight exposure to FTY720, we saw a significant increase in S1P receptor 1 (S1P1)-expressing CD68+ macrophages in subcapsular sinuses of FTY-P-treated MLNs.	FTY 720P	205-210	sphingosine-1-phosphate receptor 1	Mus musculus	128-142
16301618-3	2005	Although changes in circulating monocytes were not observed with overnight exposure to FTY720, we saw a significant increase in S1P receptor 1 (S1P1)-expressing CD68+ macrophages in subcapsular sinuses of FTY-P-treated MLNs.	FTY 720P	205-210	sphingosine-1-phosphate receptor 1	Mus musculus	144-148
16301618-5	2005	The sinus volume and number of S1P1-positive cells within sinuses were also increased by FTY-P.	FTY 720P	89-94	sphingosine-1-phosphate receptor 1	Mus musculus	31-35
16301618-6	2005	High endothelial venules and lymphatic endothelium expressed high levels of S1P1, and treatment with FTY-P resulted in intense staining and colocalization of CD31, beta-catenin, and zona occludens 1 in junctions between sinus cells.	FTY 720P	101-106	sphingosine-1-phosphate receptor 1	Mus musculus	76-80
16403835-9	2006	The protective effect of FTY-720 was reversed with VPC-44116, a selective S1P1 receptor antagonist.	Fingolimod Hydrochloride	25-32	sphingosine-1-phosphate receptor 1	Mus musculus	74-78
16403835-9	2006	The protective effect of FTY-720 was reversed with VPC-44116, a selective S1P1 receptor antagonist.	VPC44116	51-60	sphingosine-1-phosphate receptor 1	Mus musculus	74-78
16403835-10	2006	Furthermore, SEW-2871, a selective S1P1 agonist, significantly decreased plasma creatinine in a dose-response manner with a maximal reduction of approximately 70% with a dose of 10 mg/kg.	SEW2871	13-21	sphingosine-1-phosphate receptor 1	Mus musculus	35-39
16403835-10	2006	Furthermore, SEW-2871, a selective S1P1 agonist, significantly decreased plasma creatinine in a dose-response manner with a maximal reduction of approximately 70% with a dose of 10 mg/kg.	Creatinine	80-90	sphingosine-1-phosphate receptor 1	Mus musculus	35-39
16682274-1	2006	Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P).	Lysophospholipids	0-17	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
16682274-1	2006	Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	110-133	sphingosine-1-phosphate receptor 1	Mus musculus	135-138
16510307-1	2006	This study shows that sphingosine 1-phosphate (S1P) exerts an anti-migratory action in C2C12 myoblasts by reducing directional cell motility and fully abrogating the chemotactic response to insulin-like growth factor-1.	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
16510307-6	2006	Since S1P was previously shown to inhibit myoblast proliferation and stimulate myogenesis, the here identified novel biological activity is in favour of a complex physiological role of the sphingolipid in the process of muscle repair.	Sphingolipids	189-201	sphingosine-1-phosphate receptor 1	Mus musculus	6-9
16212624-7	2005	Administration of the selective S1PR1 agonist SEW2871 significantly enhanced circulating DC numbers.	SEW2871	46-53	sphingosine-1-phosphate receptor 1	Mus musculus	32-37
16093248-1	2005	Immunotherapeutic drugs that mimic sphingosine 1-phosphate (S1P) disrupt lymphocyte trafficking and cause T helper and T effector cells to be retained in secondary lymphoid tissue and away from sites of inflammation.	sphingosine 1-phosphate	35-58	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
16093248-2	2005	The prototypical therapeutic agent, 2-alkyl-2-amino-1,3-propanediol (FTY720), stimulates S1P signaling pathways only after it is phosphorylated by one or more unknown kinases.	2-alkyl-2-amino-1,3-propanediol	36-67	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
16093248-2	2005	The prototypical therapeutic agent, 2-alkyl-2-amino-1,3-propanediol (FTY720), stimulates S1P signaling pathways only after it is phosphorylated by one or more unknown kinases.	Fingolimod Hydrochloride	69-75	sphingosine-1-phosphate receptor 1	Mus musculus	89-92
16148028-4	2005	Non-sulfatable mutant (Y19,22F)S1P1 endows T cells with lower-affinity binding of [32P]S1P than wild-type S1P1 and transduces lesser effects of S1P on chemotaxis, chemokine-elicited chemotaxis, and T cell receptor-mediated proliferation and cytokine generation.	Phosphorus-32	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	87-90
16148028-1	2005	The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues.	sphingosine 1-phosphate	11-34	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
16148028-1	2005	The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues.	sphingosine 1-phosphate	11-34	sphingosine-1-phosphate receptor 1	Mus musculus	69-73
16148028-1	2005	The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues.	sphingosine 1-phosphate	11-34	sphingosine-1-phosphate receptor 1	Mus musculus	69-72
16148028-5	2005	Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P.	Tyrosine	19-27	sphingosine-1-phosphate receptor 1	Mus musculus	14-18
16148028-5	2005	Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P.	Tyrosine	19-27	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
16148028-6	2005	Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic.	Tyrosine	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	22-26
16148028-6	2005	Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic.	Tyrosine	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
16118221-3	2005	Evidence suggests that FTY720-phosphate-induced activation of S1P1 is responsible for its mechanism of action.	Fingolimod Hydrochloride	23-29	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
16148028-3	2005	However, results now show that lack of sulfation of tyrosines 19 and 22 of the extracellular N terminus of S1P1 diminishes high-affinity S1P binding and decreases S1P signaling of T cell migration and other functions.	Tyrosine	52-61	sphingosine-1-phosphate receptor 1	Mus musculus	107-111
16148028-3	2005	However, results now show that lack of sulfation of tyrosines 19 and 22 of the extracellular N terminus of S1P1 diminishes high-affinity S1P binding and decreases S1P signaling of T cell migration and other functions.	Tyrosine	52-61	sphingosine-1-phosphate receptor 1	Mus musculus	107-110
16148028-3	2005	However, results now show that lack of sulfation of tyrosines 19 and 22 of the extracellular N terminus of S1P1 diminishes high-affinity S1P binding and decreases S1P signaling of T cell migration and other functions.	Tyrosine	52-61	sphingosine-1-phosphate receptor 1	Mus musculus	137-140
16148028-4	2005	Non-sulfatable mutant (Y19,22F)S1P1 endows T cells with lower-affinity binding of [32P]S1P than wild-type S1P1 and transduces lesser effects of S1P on chemotaxis, chemokine-elicited chemotaxis, and T cell receptor-mediated proliferation and cytokine generation.	Phosphorus-32	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	31-35
16148028-4	2005	Non-sulfatable mutant (Y19,22F)S1P1 endows T cells with lower-affinity binding of [32P]S1P than wild-type S1P1 and transduces lesser effects of S1P on chemotaxis, chemokine-elicited chemotaxis, and T cell receptor-mediated proliferation and cytokine generation.	Phosphorus-32	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	31-34
16386642-1	2005	Phosphorylated FTY720 is an analog of Sphingosine 1 Phosphate (S1P) with immunosuppressive activity that negatively regulates the expression of S1P-Receptor 1.	Fingolimod Hydrochloride	15-21	sphingosine-1-phosphate receptor 1	Mus musculus	144-158
16386642-1	2005	Phosphorylated FTY720 is an analog of Sphingosine 1 Phosphate (S1P) with immunosuppressive activity that negatively regulates the expression of S1P-Receptor 1.	sphingosine 1-phosphate	38-61	sphingosine-1-phosphate receptor 1	Mus musculus	144-158
16118221-3	2005	Evidence suggests that FTY720-phosphate-induced activation of S1P1 is responsible for its mechanism of action.	Phosphates	30-39	sphingosine-1-phosphate receptor 1	Mus musculus	62-66
15659717-7	2005	Moreover, SPH was not effective in Ca(2+)-free solutions, in agreement with the hypothesis that SPH action is dependent on its conversion to S1P by the Ca(2+)-requiring enzyme SK.	Sphingosine	10-13	sphingosine-1-phosphate receptor 1	Mus musculus	141-144
16151014-4	2005	We found that S1P abundance in lymphoid tissues of mice is normally low but increases more than 100-fold after THI treatment and that this treatment inhibits the S1P-degrading enzyme S1P lyase.	2-acetyl-4(5)-tetrahydroxybutylimidazole	111-114	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
15870184-1	2005	Sphingosine-1-phosphate (S1P) and its receptor S1P1 control T-cell egress from thymus and secondary lymphoid organs (SLOs).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	47-51
15968000-2	2005	Sphingosine 1-phosphate (S1P) is a lipid mediator synthesized and/or stored in mast cells, platelets, and epithelial cells, with production up-regulated by the proinflammatory cytokines IL-1 and TNF.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15659717-2	2005	Sphingosine (SPH) and sphingosine 1-phosphate (S1P) are two major sphingomyelin derivatives present at high levels in blood.	Sphingomyelins	66-79	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
16046470-1	2005	Sphingosine 1-phosphate (S1P) has diverse effects on T cells that are mediated by the predominant S1P1 and S1P4 G protein-coupled receptors (GPCRs).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
16046470-1	2005	Sphingosine 1-phosphate (S1P) has diverse effects on T cells that are mediated by the predominant S1P1 and S1P4 G protein-coupled receptors (GPCRs).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	98-102
16116182-1	2005	Sphingosine-1-phosphate (S1P) represents a potent modulator of diverse cellular activities, including lymphocyte trafficking and maintenance of lymphocyte homeostasis.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15659717-6	2005	Interestingly, N,N-dimethylsphingosine, an inhibitor of SPH kinase (SK), abolished the effect of supplemented SPH but not that of S1P, suggesting that SPH acts through its conversion to S1P.	N,N-dimethylsphingosine	15-38	sphingosine-1-phosphate receptor 1	Mus musculus	186-189
15659717-7	2005	Moreover, SPH was not effective in Ca(2+)-free solutions, in agreement with the hypothesis that SPH action is dependent on its conversion to S1P by the Ca(2+)-requiring enzyme SK.	Sphingosine	96-99	sphingosine-1-phosphate receptor 1	Mus musculus	141-144
15659717-6	2005	Interestingly, N,N-dimethylsphingosine, an inhibitor of SPH kinase (SK), abolished the effect of supplemented SPH but not that of S1P, suggesting that SPH acts through its conversion to S1P.	Sphingosine	56-59	sphingosine-1-phosphate receptor 1	Mus musculus	186-189
15659717-6	2005	Interestingly, N,N-dimethylsphingosine, an inhibitor of SPH kinase (SK), abolished the effect of supplemented SPH but not that of S1P, suggesting that SPH acts through its conversion to S1P.	Sphingosine	110-113	sphingosine-1-phosphate receptor 1	Mus musculus	186-189
15938718-1	2005	Sphingosine 1-phosphate (S1P) functions as a ligand for the S1P/EDG family receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15938718-1	2005	Sphingosine 1-phosphate (S1P) functions as a ligand for the S1P/EDG family receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	60-63
15728255-4	2005	The cytoskeletal response was dependent on the extracellular action of S1P through its specific surface receptors, since the intracellular delivery of the sphingolipid by microinjection was unable to modify the actin cytoskeletal assembly.	Sphingolipids	155-167	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
15927078-3	2005	A pathway that has been shown to be activated via MR and to increase [Ca2+]i includes the activation of sphingosine kinases (SPHK) and the generation of the bioactive sphingolipid sphingosine 1-phosphate (S1P).	sphingolipid sphingosine 1-phosphate	167-203	sphingosine-1-phosphate receptor 1	Mus musculus	205-208
15716590-5	2005	Expression of LPA2 is accompanied by LPA-induced sphingosine-1-phosphate (S1P) production.	lysophosphatidic acid	14-17	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
15716590-6	2005	Because luteal cells, in the presence of the sphingosine kinase inhibitor dihydrosphingosine, can overcome the inhibitory effects of LPA on steroid synthesis, we suggest the possible requirement of intracellular S1P production.	safingol	74-92	sphingosine-1-phosphate receptor 1	Mus musculus	212-215
15716590-6	2005	Because luteal cells, in the presence of the sphingosine kinase inhibitor dihydrosphingosine, can overcome the inhibitory effects of LPA on steroid synthesis, we suggest the possible requirement of intracellular S1P production.	lysophosphatidic acid	133-136	sphingosine-1-phosphate receptor 1	Mus musculus	212-215
15716590-8	2005	Surprisingly, however, exogenous S1P inhibits agonist-stimulated progesterone in both cell types by inhibiting cyclic AMP accumulation, suggesting different mechanisms of action.	Progesterone	65-77	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
15716590-8	2005	Surprisingly, however, exogenous S1P inhibits agonist-stimulated progesterone in both cell types by inhibiting cyclic AMP accumulation, suggesting different mechanisms of action.	Cyclic AMP	111-121	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
15764699-3	2005	Here, we show that the bioactive lipid sphingosine 1-phosphate (S1P), which acts through the S1P2 receptor (S1P2R) G protein-coupled receptor (GPCR) to inhibit cell migration, utilizes PTEN as a signaling intermediate.	sphingosine 1-phosphate	39-62	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
15761190-2	2005	Sphingosine-1-phosphate (S1P) is a sphingolipid that binds to G protein-coupled receptors on endothelial cells (ECs).	Sphingolipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15870293-1	2005	Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, is the ligand for five specific G protein-coupled receptors, named S1P(1) to S1P(5).	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15870293-1	2005	Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, is the ligand for five specific G protein-coupled receptors, named S1P(1) to S1P(5).	Sphingolipids	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	135-141
15545521-7	2004	Because we have recently identified sphingosine 1-phosphate (S1P) as an important vasoactive component contained in HDL, we measured myocardial perfusion after administration of S1P in vivo.	sphingosine 1-phosphate	36-59	sphingosine-1-phosphate receptor 1	Mus musculus	61-64
15625079-3	2005	The S1P-dependent diminution of serum-induced labeled thymidine incorporation was abrogated by antisense oligodeoxyribonucleotides (ODN) to S1P2, but not to S1P1 or S1P3 receptor, also expressed in C2C12 cells, implicating S1P2 in the biological response.	Thymidine	54-63	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
15625079-3	2005	The S1P-dependent diminution of serum-induced labeled thymidine incorporation was abrogated by antisense oligodeoxyribonucleotides (ODN) to S1P2, but not to S1P1 or S1P3 receptor, also expressed in C2C12 cells, implicating S1P2 in the biological response.	Oligodeoxyribonucleotides	105-130	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
15728452-1	2005	Signaling by sphingosine 1-phosphate (S1P) through its receptor S1P(1) has recently been shown to promote thymocyte egress.	sphingosine 1-phosphate	13-36	sphingosine-1-phosphate receptor 1	Mus musculus	64-70
15699128-1	2005	The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) normally transduces S1P effects on lymph node (LN) egress and tissue migration of naive lymphocytes.	sphingosine 1-phosphate	11-34	sphingosine-1-phosphate receptor 1	Mus musculus	69-73
15459201-1	2004	Sphingosine-1-phosphate (S1P), a lipid signaling molecule that regulates many cellular functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase.	Sphingosine	118-129	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15459201-1	2004	Sphingosine-1-phosphate (S1P), a lipid signaling molecule that regulates many cellular functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase.	Adenosine Triphosphate	134-137	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15583019-3	2004	Here we show that a receptor for the lysophospholipid sphingosine-1-phosphate (S1P), S1P(3), is required for normal numbers of splenic immature and MZ B cells, and for S1P-induced chemotaxis of MZ B cells.	Lysophospholipids	37-53	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
15583019-3	2004	Here we show that a receptor for the lysophospholipid sphingosine-1-phosphate (S1P), S1P(3), is required for normal numbers of splenic immature and MZ B cells, and for S1P-induced chemotaxis of MZ B cells.	Lysophospholipids	37-53	sphingosine-1-phosphate receptor 1	Mus musculus	85-88
15583019-3	2004	Here we show that a receptor for the lysophospholipid sphingosine-1-phosphate (S1P), S1P(3), is required for normal numbers of splenic immature and MZ B cells, and for S1P-induced chemotaxis of MZ B cells.	Lysophospholipids	37-53	sphingosine-1-phosphate receptor 1	Mus musculus	85-88
15707407-1	2005	The sphingolipid drug FTY720 displays structural similarity to S1P and efficacy as an immunosuppressant in models of autoimmune disease and in solid organ transplantation.	Sphingolipids	4-16	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
15728487-7	2005	Most notably, we also identified the lysophospholipid sphingosine 1-phosphate (S1P) as a potent chemoattractant for immature LC, which expressed mRNA transcripts of lysophospholipid receptors S1P(1-4).	Lysophospholipids	37-53	sphingosine-1-phosphate receptor 1	Mus musculus	79-82
15728487-7	2005	Most notably, we also identified the lysophospholipid sphingosine 1-phosphate (S1P) as a potent chemoattractant for immature LC, which expressed mRNA transcripts of lysophospholipid receptors S1P(1-4).	Lysophospholipids	37-53	sphingosine-1-phosphate receptor 1	Mus musculus	192-195
15728487-8	2005	Additional experiments with specific ASO showed that the Galpha(i)-coupled receptors S1P(1) and S1P(3) were dominantly involved in the S1P-induced migration.	Oligonucleotides, Antisense	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	85-88
15728487-8	2005	Additional experiments with specific ASO showed that the Galpha(i)-coupled receptors S1P(1) and S1P(3) were dominantly involved in the S1P-induced migration.	Oligonucleotides, Antisense	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
15728487-8	2005	Additional experiments with specific ASO showed that the Galpha(i)-coupled receptors S1P(1) and S1P(3) were dominantly involved in the S1P-induced migration.	Oligonucleotides, Antisense	37-40	sphingosine-1-phosphate receptor 1	Mus musculus	96-99
15684337-1	2005	Sphingosine kinase (SPHK) catalyzes sphingosine phosphorylation to form a bioactive lipid mediator, sphingosine-1-phosphate (S1P).	Sphingosine	36-47	sphingosine-1-phosphate receptor 1	Mus musculus	125-128
15292266-1	2004	Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the S1P subfamily of G-protein-coupled Edg receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15292266-1	2004	Sphingosine 1-phosphate (S1P) is a lipid agonist that regulates smooth muscle cell (SMC) and endothelial cell functions by activating several members of the S1P subfamily of G-protein-coupled Edg receptors.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	157-160
15292266-5	2004	In SMC and 10T1/2 cells, S1P treatment up-regulated the activities of several transiently transfected SMC-specific promoters, and these effects were inhibited by the Rho-kinase inhibitor, Y-27632.	Y 27632	188-195	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
14982946-1	2004	The lysophospholipid (LPL) growth factors sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are generated by macrophages, dendritic cells, mast cells, and platelets, which leads to lymph and plasma concentrations of 0.1-1 microM.	Lysophospholipids	4-20	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
15109308-2	2004	Recent studies have shown that sphingosine 1-phosphate (S1P), generated by the action of sphingosine kinase (SphK) on Sph, also possesses biological activity, acting as an intracellular messenger, as well as an extracellular ligand for specific membrane receptors.	sphingosine 1-phosphate	31-54	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
15109308-2	2004	Recent studies have shown that sphingosine 1-phosphate (S1P), generated by the action of sphingosine kinase (SphK) on Sph, also possesses biological activity, acting as an intracellular messenger, as well as an extracellular ligand for specific membrane receptors.	Sphingosine	109-112	sphingosine-1-phosphate receptor 1	Mus musculus	56-59
15109308-3	2004	At present, however, it is not clear whether the biological effects elicited by Sph are attributable to its conversion into S1P.	Sphingosine	80-83	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
15109308-4	2004	In the present study, we show that Sph significantly stimulated phospholipase D (PLD) activity in mouse C2C12 myoblasts via a previously unrecognized mechanism that requires the conversion of Sph into S1P and its subsequent action as extracellular ligand.	Sphingosine	35-38	sphingosine-1-phosphate receptor 1	Mus musculus	201-204
15109308-6	2004	Moreover, the crucial role of SphK-derived S1P in the activation of PLD by Sph was confirmed by the observed potentiated effect of Sph in myoblasts where SphK1 was overexpressed, and the attenuated response in cells transfected with the dominant negative form of SphK1.	Sphingosine	30-33	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
15109308-6	2004	Moreover, the crucial role of SphK-derived S1P in the activation of PLD by Sph was confirmed by the observed potentiated effect of Sph in myoblasts where SphK1 was overexpressed, and the attenuated response in cells transfected with the dominant negative form of SphK1.	Sphingosine	75-78	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
15109308-7	2004	Notably, the measurement of S1P formation in vivo by employing labelled ATP revealed that cell-associated SphK activity in the extracellular compartment largely contributed to the transformation of Sph into S1P, with the amount of SphK released into the medium being negligible.	Adenosine Triphosphate	72-75	sphingosine-1-phosphate receptor 1	Mus musculus	28-31
15191888-2	2004	Sphingosine kinase-1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1 phosphate (S1P), a sphingolipid metabolite that plays important roles in angiogenesis, inflammation, and cell growth.	Sphingosine	57-68	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
15191888-2	2004	Sphingosine kinase-1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1 phosphate (S1P), a sphingolipid metabolite that plays important roles in angiogenesis, inflammation, and cell growth.	sphingosine 1-phosphate	72-95	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
15191888-2	2004	Sphingosine kinase-1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1 phosphate (S1P), a sphingolipid metabolite that plays important roles in angiogenesis, inflammation, and cell growth.	Sphingolipids	105-117	sphingosine-1-phosphate receptor 1	Mus musculus	97-100
15191888-9	2004	Treatment of endothelial cells with the p38 MAPK inhibitor SB-203580 suppressed S1P-induced MCP-1 protein secretion.	SB 203580	59-68	sphingosine-1-phosphate receptor 1	Mus musculus	80-83
15258895-1	2004	The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes.	Lysophospholipids	4-21	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
15258895-1	2004	The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes.	sphingosine 1-phosphate	22-45	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
15541015-5	2004	5 The S1P3 receptor antagonist suramin (100 microM) significantly inhibited responses to S1P and SPC in rats but not in mice, and did not affect noradrenaline responses in either species.	Suramin	31-38	sphingosine-1-phosphate receptor 1	Mus musculus	6-9
15541015-8	2004	Responses to S1P and SPC differ between both species with regard to suramin-sensitivity indicating involvement of different receptor subtypes for lysosphingolipids in both species.	Suramin	68-75	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
14982946-1	2004	The lysophospholipid (LPL) growth factors sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are generated by macrophages, dendritic cells, mast cells, and platelets, which leads to lymph and plasma concentrations of 0.1-1 microM.	Lysophospholipids	22-25	sphingosine-1-phosphate receptor 1	Mus musculus	67-70
15084513-1	2004	Sphingosine 1-phosphate (S1P) evokes T cell chemotaxis at 1-100 nM and inhibits chemotaxis to chemokines at 300 nM-1 uM through their predominant S1P1 G protein-coupled receptor (R).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15020292-5	2004	S1P produced an approximately 40-50% reduction in LPS-mediated extravasation of Evans blue dye albumin, bronchoalveolar lavage protein content, and lung tissue myeloperoxidase activity (reflecting phagocyte infiltration).	Evans Blue	80-94	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
15020292-6	2004	Consistent with systemic barrier enhancement, S1P significantly decreased Evans blue dye albumin extravasation and myeloperoxidase content in renal tissues of LPS-treated mice.	Evans Blue	74-88	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
15084513-1	2004	Sphingosine 1-phosphate (S1P) evokes T cell chemotaxis at 1-100 nM and inhibits chemotaxis to chemokines at 300 nM-1 uM through their predominant S1P1 G protein-coupled receptor (R).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	146-150
15084513-3	2004	CD4+25+ T cell suppression of 3H-thymidine uptake and IL-2 generation by CD4+25- T cells stimulated with anti-T cell receptor antibodies without S1P was enhanced significantly by S1P at normal blood and lymph concentrations.	3h-thymidine	30-42	sphingosine-1-phosphate receptor 1	Mus musculus	179-182
15143482-1	2004	Sphingosine 1-phosphate (S1P), a polar sphingolipid metabolite, is involved in a wide spectrum of biological processes, including Ca(++) mobilization, cell growth, differentiation, motility, and cytoskeleton organization.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15143482-1	2004	Sphingosine 1-phosphate (S1P), a polar sphingolipid metabolite, is involved in a wide spectrum of biological processes, including Ca(++) mobilization, cell growth, differentiation, motility, and cytoskeleton organization.	Sphingolipids	39-51	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
14657000-2	2004	We investigated the potential interaction between sphingosine-1-phosphate (S1P) and platelet-derived growth factor (PDGF) in the Akt signaling pathway.	sphingosine 1-phosphate	50-73	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
15063179-3	2004	Sphingosine 1-phosphate, a platelet-derived lipid mediator, regulates angiogenesis and vascular maturation via its action on the G-protein-coupled receptor S1P(1) (also known as EDG-1).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	156-162
15063179-3	2004	Sphingosine 1-phosphate, a platelet-derived lipid mediator, regulates angiogenesis and vascular maturation via its action on the G-protein-coupled receptor S1P(1) (also known as EDG-1).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	178-183
14719124-2	2004	Previously, we have shown that several secretion products from platelets and mast cells such as histamine, sphingosine-1-phosphate (S1P), and lysophosphatidic acid (LPA) have chemotactic activity towards immature human DC.	sphingosine 1-phosphate	107-130	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
15134901-1	2004	Sphingosine 1-phosphate (S1P) type 1G protein-coupled receptors (S1P1 GPCRs) are specific high-affinity transducers for this lipid growth factor and cellular mediator.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	65-69
14732717-4	2004	A potent, S1P(1)-receptor selective agonist structurally unrelated to S1P was found to activate multiple signals triggered by S1P, including guanosine 5"-3-O-(thio)triphosphate binding, calcium flux, Akt and ERK1/2 phosphorylation, and stimulation of migration of S1P(1)- but not S1P(3)-expressing cells in vitro.	Guanosine 5'-O-(3-Thiotriphosphate)	141-176	sphingosine-1-phosphate receptor 1	Mus musculus	10-13
14657000-6	2004	Importantly, S1P induced a Gi-dependent tyrosine phosphorylation of PDGFR in HEY cells.	Tyrosine	40-48	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
14657000-4	2004	In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of S1P and PDGFR in MEFs.	6,7-dimethoxy-3-phenylquinoxaline	119-125	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
14657000-4	2004	In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of S1P and PDGFR in MEFs.	6,7-dimethoxy-3-phenylquinoxaline	119-125	sphingosine-1-phosphate receptor 1	Mus musculus	140-143
14584038-1	2004	We have previously shown that sphingosine 1-phosphate (S1P) can induce intracellular Ca(2+) mobilization and cell contraction in C2C12 myoblasts and that the two phenomena are temporally unrelated.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
14689477-3	2004	Sphingosine kinase (SPHK) is an enzyme that converts sphingosine (Sph) into sphingosine-1-phosphate (S1P).	Sphingosine	53-64	sphingosine-1-phosphate receptor 1	Mus musculus	101-104
14689477-3	2004	Sphingosine kinase (SPHK) is an enzyme that converts sphingosine (Sph) into sphingosine-1-phosphate (S1P).	Sphingosine	0-3	sphingosine-1-phosphate receptor 1	Mus musculus	101-104
14689477-3	2004	Sphingosine kinase (SPHK) is an enzyme that converts sphingosine (Sph) into sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	76-99	sphingosine-1-phosphate receptor 1	Mus musculus	101-104
15655330-7	2004	Exogenous S1P-induced myoblastic cell contraction was temporally unrelated to S1P-induced intracellular Ca(2+) increase; cell contraction occurred within 5-8 s from stimulation, whereas intracellular Ca(2+) increase was evident only after 15-25 s. To support the Ca(2+) independence of myoblastic cell contraction, the cells were pretreated with a Ca(2+) chelator, BAPTA/AM, prior to stimulation with S1P.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	365-370	sphingosine-1-phosphate receptor 1	Mus musculus	10-13
14584038-7	2004	Experimental evidence demonstrating the involvement of Rho pathway in S1P-stimulated myoblast contraction included: the activation/translocation of RhoA to the membrane in response to agonist-stimulation in cells depleted of Ca(2+) and the inhibition of dynamic changes of the actin cytoskeleton in cells where Rho functions had been inhibited either by overexpression of RhoGDI, a physiological inhibitor of GDP dissociation from Rho proteins, or by pretreatment with Y-27632, a specific Rho kinase inhibitor.	Guanosine Diphosphate	409-412	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
14584038-7	2004	Experimental evidence demonstrating the involvement of Rho pathway in S1P-stimulated myoblast contraction included: the activation/translocation of RhoA to the membrane in response to agonist-stimulation in cells depleted of Ca(2+) and the inhibition of dynamic changes of the actin cytoskeleton in cells where Rho functions had been inhibited either by overexpression of RhoGDI, a physiological inhibitor of GDP dissociation from Rho proteins, or by pretreatment with Y-27632, a specific Rho kinase inhibitor.	Y 27632	469-476	sphingosine-1-phosphate receptor 1	Mus musculus	70-73
12963721-1	2003	Sphingosine 1-phosphate (S1P) is the ligand for a family of specific G protein-coupled receptors (GPCRs) that regulate a wide variety of important cellular functions, including growth, survival, cytoskeletal rearrangements, and cell motility.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
15165038-1	2004	S1P1 (also known as EDG-1) is a G-protein coupled receptor for the bioactive lipid, sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	84-107	sphingosine-1-phosphate receptor 1	Mus musculus	0-4
15165038-1	2004	S1P1 (also known as EDG-1) is a G-protein coupled receptor for the bioactive lipid, sphingosine-1-phosphate (S1P).	sphingosine 1-phosphate	84-107	sphingosine-1-phosphate receptor 1	Mus musculus	20-25
14500646-3	2003	Uptake of [(3)H]thymidine by mouse CD4 T cells stimulated with anti-CD3 mAbs plus either anti-CD28 or IL-7 was inhibited up to 50% by 10(-9)-10(-6) M S1P.	[(3)h]thymidine	10-25	sphingosine-1-phosphate receptor 1	Mus musculus	150-153
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	Ceramides	25-33	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	Ceramides	25-33	sphingosine-1-phosphate receptor 1	Mus musculus	86-89
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	c8-ceramine	42-53	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	c8-ceramine	42-53	sphingosine-1-phosphate receptor 1	Mus musculus	86-89
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	ceramine	45-53	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
14608042-2	2003	Apoptosis induced by the ceramide analog, C8-ceramine, was inhibited by S1P (ceramine/S1P).	ceramine	45-53	sphingosine-1-phosphate receptor 1	Mus musculus	86-89
14608042-3	2003	Stress activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK) activation was significantly higher after ceramine and ceramine/S1P treatments.	ceramine	125-133	sphingosine-1-phosphate receptor 1	Mus musculus	134-137
14608042-4	2003	Ceramine/S1P treatment also significantly increased ERK activation and MKP-1 protein levels.	ceramine	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
14608042-5	2003	ERK activation was required for the inhibition of apoptosis by S1P as shown using the mitogen-activated protein kinase kinase inhibitor, PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	137-144	sphingosine-1-phosphate receptor 1	Mus musculus	63-66
14500646-4	2003	Suppression by S1P required Ca(2+) signaling and was reduced by intracellular cAMP.	Cyclic AMP	78-82	sphingosine-1-phosphate receptor 1	Mus musculus	15-18
12810709-2	2003	We investigated mechanisms for inhibition of B16 melanoma cell migration and invasion by sphingosine-1-phosphate (S1P), which is the ligand for the Edg family G protein-coupled receptors and also implicated as an intracellular second messenger.	sphingosine 1-phosphate	89-112	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
14500380-4	2003	We now extend the substrate specificity to sphingosylphosphorylcholine (SPC), which ATX hydrolyzes to sphingosine-1-phosphate (S1P).	sphingosine phosphorylcholine	43-70	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
14500380-4	2003	We now extend the substrate specificity to sphingosylphosphorylcholine (SPC), which ATX hydrolyzes to sphingosine-1-phosphate (S1P).	sphingosine phosphorylcholine	72-75	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
12763936-3	2003	KRX-725 mimics the effects of sphingosine 1-phosphate (S1P), the natural ligand of S1P3, by triggering a Gi-dependent MEK-ERK (mitogen-activated protein kinase kinase and extracellular signal-regulated kinase) signal transduction pathway.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
12943676-1	2003	Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediator, sphingosine 1-phosphate (S1P).	Sphingosine	41-52	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
12943676-1	2003	Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediator, sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	89-112	sphingosine-1-phosphate receptor 1	Mus musculus	114-117
12810709-5	2003	In addition, JTE013 abrogated the inhibition by sphingosine, which is the S1P precursor but not an agonist for S1P receptors, indicating that the sphingosine effects were mediated via S1P2 stimulation, most likely by S1P that was converted from sphingosine.	JTE 013	13-19	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
12810709-5	2003	In addition, JTE013 abrogated the inhibition by sphingosine, which is the S1P precursor but not an agonist for S1P receptors, indicating that the sphingosine effects were mediated via S1P2 stimulation, most likely by S1P that was converted from sphingosine.	Sphingosine	48-59	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
12810709-5	2003	In addition, JTE013 abrogated the inhibition by sphingosine, which is the S1P precursor but not an agonist for S1P receptors, indicating that the sphingosine effects were mediated via S1P2 stimulation, most likely by S1P that was converted from sphingosine.	Sphingosine	146-157	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
12810709-5	2003	In addition, JTE013 abrogated the inhibition by sphingosine, which is the S1P precursor but not an agonist for S1P receptors, indicating that the sphingosine effects were mediated via S1P2 stimulation, most likely by S1P that was converted from sphingosine.	Sphingosine	146-157	sphingosine-1-phosphate receptor 1	Mus musculus	74-77
12890694-5	2003	Sphingosine-1-phosphate (S1P) induced both COX-2 and PGE2 in a dose-responsive manner with an apparent ED50 of 100-300 nM.	Dinoprostone	53-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12890694-10	2003	By contrast, cells treated with RNAi to S1P lyase or S1P phosphatase enhanced COX-2 induction leading to enhanced generation of PGE2.	Dinoprostone	128-132	sphingosine-1-phosphate receptor 1	Mus musculus	40-43
12890694-10	2003	By contrast, cells treated with RNAi to S1P lyase or S1P phosphatase enhanced COX-2 induction leading to enhanced generation of PGE2.	Dinoprostone	128-132	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
12890694-11	2003	Treatment with SK1 RNAi also abolished the effects of exogenous sphingosine and ceramide on PGE2, revealing that the action of sphingosine and ceramide are due to intracellular metabolism into S1P.	Sphingosine	127-138	sphingosine-1-phosphate receptor 1	Mus musculus	193-196
12890694-11	2003	Treatment with SK1 RNAi also abolished the effects of exogenous sphingosine and ceramide on PGE2, revealing that the action of sphingosine and ceramide are due to intracellular metabolism into S1P.	Ceramides	143-151	sphingosine-1-phosphate receptor 1	Mus musculus	193-196
12890694-12	2003	Collectively, these results provide novel evidence that SK1 and S1P are necessary for TNF to induce COX-2 and PGE2 production.	Dinoprostone	110-114	sphingosine-1-phosphate receptor 1	Mus musculus	64-67
12782628-1	2003	Sphingosine 1-phosphate (S1P) from mononuclear phagocytes and platelets signals T cells predominantly through S1P1 G protein-coupled receptors (Rs) to enhance survival, stimulate and suppress migration, and inhibit other immunologically relevant responses.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12782628-1	2003	Sphingosine 1-phosphate (S1P) from mononuclear phagocytes and platelets signals T cells predominantly through S1P1 G protein-coupled receptors (Rs) to enhance survival, stimulate and suppress migration, and inhibit other immunologically relevant responses.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	110-114
12782628-5	2003	The same PKCepsilon inhibitors blocked S1P-evoked increases in T cell nuclear levels of c-Fos and phosphorylated c-Jun and JunD after 24 h, but not 1 h. A mixture of c-Fos plus c-Jun antisense oligonucleotides prevented late recovery of down-regulated CT and CI, without affecting S1P induction of down-regulation.	Oligonucleotides	193-209	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
12782628-6	2003	Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a selective inhibitor of PKCepsilon after 24 h, but not 1 h. Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation.	Threonine	24-33	sphingosine-1-phosphate receptor 1	Mus musculus	11-14
12782628-6	2003	Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a selective inhibitor of PKCepsilon after 24 h, but not 1 h. Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation.	Threonine	24-33	sphingosine-1-phosphate receptor 1	Mus musculus	53-57
12782628-6	2003	Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a selective inhibitor of PKCepsilon after 24 h, but not 1 h. Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation.	Threonine	24-33	sphingosine-1-phosphate receptor 1	Mus musculus	194-198
12782628-6	2003	Similarly, S1P-elicited threonine phosphorylation of S1P1 Rs was suppressed by a selective inhibitor of PKCepsilon after 24 h, but not 1 h. Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation.	Threonine	24-33	sphingosine-1-phosphate receptor 1	Mus musculus	53-56
12665551-3	2003	Therefore, we investigated the actions of S1P on melanin synthesis using a spontaneously immortalized mouse melanocyte cell line, Mel-Ab.	Melanins	49-56	sphingosine-1-phosphate receptor 1	Mus musculus	42-45
12742827-5	2003	S1P-induced vasodilation is abrogated by removal of endothelium or by the addition of the NOS inhibitor N(omega)-monomethyl-l-arginine but is not affected by the cyclooxygenase inhibitor indomethacin, nor by the blockade of K(+) channels by using 4-aminopyridine.	omega-N-Methylarginine	104-134	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12742827-5	2003	S1P-induced vasodilation is abrogated by removal of endothelium or by the addition of the NOS inhibitor N(omega)-monomethyl-l-arginine but is not affected by the cyclooxygenase inhibitor indomethacin, nor by the blockade of K(+) channels by using 4-aminopyridine.	Indomethacin	187-199	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12742827-5	2003	S1P-induced vasodilation is abrogated by removal of endothelium or by the addition of the NOS inhibitor N(omega)-monomethyl-l-arginine but is not affected by the cyclooxygenase inhibitor indomethacin, nor by the blockade of K(+) channels by using 4-aminopyridine.	4-Aminopyridine	247-262	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12742827-6	2003	S1P-induced vasodilation is attenuated by pertussis toxin, by the phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin, and by the calcium chelator BAPTA.	Wortmannin	115-125	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12742827-6	2003	S1P-induced vasodilation is attenuated by pertussis toxin, by the phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin, and by the calcium chelator BAPTA.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	155-160	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
12742827-7	2003	With the use of high-sensitivity protein immunoblots in extracts from single pressurized vessels, we found that S1P, but not bradykinin, promotes the phosphorylation of eNOS at Ser(1179).	Serine	177-180	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
12742827-8	2003	Maximum S1P-induced eNOS Ser(1179) phosphorylation was reached at the time of maximum vasorelaxation, but enzyme phosphorylation persisted for several minutes after vasodilation had resolved.	Serine	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	8-11
12742827-10	2003	Taken together, our findings demonstrate that S1P, an important intercellular mediator of platelet-vessel wall interactions, is a effective arteriolar vasodilator that acts via G protein-dependent, calcium-sensitive, and PI3-kinase-modulated signaling pathways.	Calcium	198-205	sphingosine-1-phosphate receptor 1	Mus musculus	46-49
12842709-2	2003	In this study we examined the effect of sphingosine-1-phosphate (S1P), a platelet-derived bioactive lysophospholipid that is believed to specifically stimulate EC migration and tube formation, on the angiogenic properties of MSC.	Lysophospholipids	100-116	sphingosine-1-phosphate receptor 1	Mus musculus	65-68
12842709-7	2003	Ilomastat, a broad-spectrum MMP inhibitor, antagonized several angiogenic and S1P-mediated events in MSC.	ilomastat	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	78-81
12842709-10	2003	In addition, anti-angiogenic agents such as Ilomastat, Neovastat, and green tea polyphenol epigallocatechin-3-gallate antagonized the S1P-induced migration of MSC as well as that of transfected COS-7 cells overexpressing the recombinant receptor for S1P, EDG-1.	polyphenol epigallocatechin-3-gallate	80-117	sphingosine-1-phosphate receptor 1	Mus musculus	134-137
12842709-10	2003	In addition, anti-angiogenic agents such as Ilomastat, Neovastat, and green tea polyphenol epigallocatechin-3-gallate antagonized the S1P-induced migration of MSC as well as that of transfected COS-7 cells overexpressing the recombinant receptor for S1P, EDG-1.	polyphenol epigallocatechin-3-gallate	80-117	sphingosine-1-phosphate receptor 1	Mus musculus	250-253
12842709-10	2003	In addition, anti-angiogenic agents such as Ilomastat, Neovastat, and green tea polyphenol epigallocatechin-3-gallate antagonized the S1P-induced migration of MSC as well as that of transfected COS-7 cells overexpressing the recombinant receptor for S1P, EDG-1.	polyphenol epigallocatechin-3-gallate	80-117	sphingosine-1-phosphate receptor 1	Mus musculus	255-260
12842709-10	2003	In addition, anti-angiogenic agents such as Ilomastat, Neovastat, and green tea polyphenol epigallocatechin-3-gallate antagonized the S1P-induced migration of MSC as well as that of transfected COS-7 cells overexpressing the recombinant receptor for S1P, EDG-1.	cos-7	194-199	sphingosine-1-phosphate receptor 1	Mus musculus	134-137
12665551-9	2003	These results indicate that the ERK pathway is potently involved in the melanogenic signaling cascade, and that S1P-induced ERK activation contributes to reduced melanin synthesis via MITF degradation.	Melanins	162-169	sphingosine-1-phosphate receptor 1	Mus musculus	112-115
12665551-10	2003	Therefore, we suggest that S1P reduces melanin synthesis by ERK activation, MITF phosphorylation and degradation, and by the subsequent downregulation of tyrosinase and TRP-1 production.	Melanins	39-46	sphingosine-1-phosphate receptor 1	Mus musculus	27-30
12665551-4	2003	This study shows that S1P significantly inhibits melanin synthesis in a concentration-dependent manner, and also that the activity of tyrosinase was reduced in S1P-treated cells.	Melanins	49-56	sphingosine-1-phosphate receptor 1	Mus musculus	22-25
12665551-4	2003	This study shows that S1P significantly inhibits melanin synthesis in a concentration-dependent manner, and also that the activity of tyrosinase was reduced in S1P-treated cells.	Melanins	49-56	sphingosine-1-phosphate receptor 1	Mus musculus	160-163
12665551-5	2003	In contrast, a specific extracellular signal-regulated protein kinase (ERK) pathway inhibitor, PD98059, increased tyrosinase activity and melanin production, and PD98059 also restored the S1P-induced reduction of tyrosinase activity and pigmentation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	95-102	sphingosine-1-phosphate receptor 1	Mus musculus	188-191
12665551-5	2003	In contrast, a specific extracellular signal-regulated protein kinase (ERK) pathway inhibitor, PD98059, increased tyrosinase activity and melanin production, and PD98059 also restored the S1P-induced reduction of tyrosinase activity and pigmentation.	Melanins	138-145	sphingosine-1-phosphate receptor 1	Mus musculus	188-191
12665551-5	2003	In contrast, a specific extracellular signal-regulated protein kinase (ERK) pathway inhibitor, PD98059, increased tyrosinase activity and melanin production, and PD98059 also restored the S1P-induced reduction of tyrosinase activity and pigmentation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	162-169	sphingosine-1-phosphate receptor 1	Mus musculus	188-191
12665551-8	2003	PD98059 was found to prevent the S1P-induced MITF phosphorylation and degradation and to abrogate the S1P-induced downregulation of tyrosinase and of tyrosinase-related protein 1 (TRP1) production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	33-36
12665551-8	2003	PD98059 was found to prevent the S1P-induced MITF phosphorylation and degradation and to abrogate the S1P-induced downregulation of tyrosinase and of tyrosinase-related protein 1 (TRP1) production.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	102-105
12646631-2	2003	We recently demonstrated that FTY-phosphate, the active metabolite of FTY720, acts as a full agonist for sphingosine-1-phosphate (S1P) receptors.	fty-phosphate	30-43	sphingosine-1-phosphate receptor 1	Mus musculus	130-133
12833634-1	2003	Sphingosine 1-phosphate (S1P) is a powerful bioactive sphingolipid recently recognized to act as extracellular ligand for various subtypes of G protein-coupled receptors belonging to the S1P family.	Sphingolipids	54-66	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12833634-1	2003	Sphingosine 1-phosphate (S1P) is a powerful bioactive sphingolipid recently recognized to act as extracellular ligand for various subtypes of G protein-coupled receptors belonging to the S1P family.	Sphingolipids	54-66	sphingosine-1-phosphate receptor 1	Mus musculus	187-190
12468451-1	2002	Sphingosine 1-phosphate (S1P) from platelets and macrophages stimulates migration and enhances survival of T cells.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12446603-1	2002	The naturally occurring phospholipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) have recently emerged as bioactive compounds that exert mitogenic effects in many cell types, including osteoblasts.	Phospholipids	24-37	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
12446603-1	2002	The naturally occurring phospholipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) have recently emerged as bioactive compounds that exert mitogenic effects in many cell types, including osteoblasts.	sphingosine 1-phosphate	70-93	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
12446603-3	2002	Using terminal deoxynucleotidyl transferase-mediated deoxyuridine 5"-triphosphate nick-end labeling and DNA fragmentation assays, we found that both LPA and S1P dose-dependently inhibited (by at least 50% and 40%, respectively) the apoptosis induced by serum withdrawal in cultures of primary calvarial rat osteoblasts and SaOS-2 cells.	deoxyuridine triphosphate	53-81	sphingosine-1-phosphate receptor 1	Mus musculus	157-160
12557151-1	2003	BACKGROUND &amp; AIMS: Sphingosine 1-phosphate (S1P), a ligand for G protein-coupled endothelial differentiation gene-1 (Edg-1), Edg-3, Edg-5, Edg-6, and Edg-8, elicits a variety of responses by cells.	Adenosine Monophosphate	12-15	sphingosine-1-phosphate receptor 1	Mus musculus	48-51
12557151-1	2003	BACKGROUND &amp; AIMS: Sphingosine 1-phosphate (S1P), a ligand for G protein-coupled endothelial differentiation gene-1 (Edg-1), Edg-3, Edg-5, Edg-6, and Edg-8, elicits a variety of responses by cells.	sphingosine 1-phosphate	23-46	sphingosine-1-phosphate receptor 1	Mus musculus	48-51
12505153-1	2003	Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, signals via G protein-coupled receptors (GPCR).	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
14870969-1	2003	Sphingosine 1-phosphate (S1P) activates a subset of plasma membrane receptors of the endothelial differentiation gene family (EdgRs) in many cell types.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
14870969-8	2003	Suramin (200 microM) significantly reduced, by approximately 90%, the effects of S1P on ICM and I(Ca), suggesting that most of S1P action occurred via Edg-3Rs.	Suramin	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	81-84
14870969-8	2003	Suramin (200 microM) significantly reduced, by approximately 90%, the effects of S1P on ICM and I(Ca), suggesting that most of S1P action occurred via Edg-3Rs.	Suramin	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	127-130
12006579-1	2002	Five cognate G protein-coupled receptors (S1P(1-5)) have been shown to mediate various cellular effects of sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	107-130	sphingosine-1-phosphate receptor 1	Mus musculus	42-45
12363041-5	2002	However, for the first time, in S1P-stimulated NIH 3T3 cells, increased levels of GCS-HS mRNA were shown to be related to increases in the reduced glutathione synthesis rate similar to those obtained after PMA and PDGF stimulation.	Glutathione	147-158	sphingosine-1-phosphate receptor 1	Mus musculus	32-35
12006579-1	2002	Five cognate G protein-coupled receptors (S1P(1-5)) have been shown to mediate various cellular effects of sphingosine 1-phosphate (S1P).	sphingosine 1-phosphate	107-130	sphingosine-1-phosphate receptor 1	Mus musculus	132-135
12006579-6	2002	Wild-type MEFs were responsive to S1P in activation of Rho and phospholipase C (PLC), intracellular calcium mobilization, and inhibition of forskolin-activated adenylyl cyclase.	Calcium	100-107	sphingosine-1-phosphate receptor 1	Mus musculus	34-37
12006579-6	2002	Wild-type MEFs were responsive to S1P in activation of Rho and phospholipase C (PLC), intracellular calcium mobilization, and inhibition of forskolin-activated adenylyl cyclase.	Colforsin	140-149	sphingosine-1-phosphate receptor 1	Mus musculus	34-37
11697799-5	2001	Of the Edg receptors known to bind SPH derivatives in other cell types, MC3T3-E1 cells were found to express transcripts encoding Edg-1 and Edg-5 but not Edg-3, Edg-6, or Edg-8.	Sphingosine	35-38	sphingosine-1-phosphate receptor 1	Mus musculus	130-135
12003800-1	2002	Sphingosine-1-phosphate (S1P) protects neonatal rat cardiac myocytes from hypoxic damage through unknown signaling pathways.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12069829-1	2002	Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5.	lysophosphatidic acid	0-21	sphingosine-1-phosphate receptor 1	Mus musculus	154-158
12069829-1	2002	Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5.	lysophosphatidic acid	23-26	sphingosine-1-phosphate receptor 1	Mus musculus	154-158
12069829-1	2002	Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5.	sphingosine 1-phosphate	32-55	sphingosine-1-phosphate receptor 1	Mus musculus	154-158
12069835-1	2002	The biological roles of phospholipid growth factors lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) have been broadly investigated.	Phospholipids	24-36	sphingosine-1-phosphate receptor 1	Mus musculus	109-112
12038970-1	2002	Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are blood-borne lysophospholipids with a wide spectrum of biological activities, which include stimulation of cell growth, prevention of apoptosis, regulation of actin cytoskeleton, and modulation of cell shape, cell migration, and invasion.	Lysophospholipids	78-95	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
12062172-1	2002	Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite that regulates diverse biological functions.	Sphingolipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11839279-2	2002	Neuronal N1E-115 cells show dramatic neurite retraction and cell rounding in response to serum factors such as lysophosphatidic acid (LPA), sphingosine-1 phosphate (S1P), and thrombin, due to activation of the RhoA-Rho kinase pathway.	sphingosine 1-phosphate	140-163	sphingosine-1-phosphate receptor 1	Mus musculus	165-168
11788469-5	2002	S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of NOS.	NG-Nitroarginine Methyl Ester	157-192	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11788469-5	2002	S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of NOS.	NG-Nitroarginine Methyl Ester	157-192	sphingosine-1-phosphate receptor 1	Mus musculus	105-108
11788469-5	2002	S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of NOS.	NG-Nitroarginine Methyl Ester	194-200	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11788469-5	2002	S1P increased capillary ingrowth into subcutaneously implanted Matrigel plugs in mice, and the effect of S1P was significantly reduced in mice that received N(G)-nitro- L-arginine methyl ester (L-NAME), an inhibitor of NOS.	NG-Nitroarginine Methyl Ester	194-200	sphingosine-1-phosphate receptor 1	Mus musculus	105-108
11788469-6	2002	S1P stimulated EC migration and tube formation on Matrigel, which processes were significantly decreased by inhibition of activities of PI3K, Akt, or eNOS, whereas treatment with LY294002, a PI3K inhibitor, but not L-NAME, inhibited EC viability and proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	179-187	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11694603-7	2001	With the addition of S1P with NOE and MAPP as well as with ceramide, treatments reduced the apoptotic response by 30 and 35%, respectively; whereas the addition of S1P with the DMS only and ceramide with DMS treatments reduced the apoptotic response by 60 and 70%, respectively.	Ceramides	190-198	sphingosine-1-phosphate receptor 1	Mus musculus	21-24
11694603-8	2001	Studies using labeled ceramide demonstrated ceramide was metabolized to S1P.	Ceramides	22-30	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
11694603-8	2001	Studies using labeled ceramide demonstrated ceramide was metabolized to S1P.	Ceramides	44-52	sphingosine-1-phosphate receptor 1	Mus musculus	72-75
11697799-10	2001	The data support a model in which SPP and SPC bind Edg-1 and/or Edg-5 receptors in osteoblasts leading to the release of Ca2+ from the ER through IP3-gated channels.	Inositol 1,4,5-Trisphosphate	146-149	sphingosine-1-phosphate receptor 1	Mus musculus	51-56
11422447-1	2001	Sphingosine-1-phosphate (S1P) is a potent lysophospholipid mediator mostly released by activated platelets.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11467306-1	2001	Sphingosine-1-phosphate (S1P) is a potent lysophospholipid mediator mostly released by activated platelets.	Lysophospholipids	42-58	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11422447-1	2001	Sphingosine-1-phosphate (S1P) is a potent lysophospholipid mediator mostly released by activated platelets.	Lysophospholipids	42-58	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11467306-5	2001	S1P stimulated thymidine incorporation and induced activation of extracellular signal-regulated kinases (Erks).	Thymidine	15-24	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11422447-5	2001	S1P stimulated thymidine incorporation and induced activation of extracellular signal-regulated kinases (Erks).	Thymidine	15-24	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11467306-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	Phorbol Esters	108-121	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11422447-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	Phorbol Esters	108-121	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11467306-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11422447-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	133-141	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11467306-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	Phorbol Esters	146-159	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11422447-7	2001	The S1P-evoked activation of Erk1 was totally blocked in astrocytes pretreated with a combination of either phorbol ester (24 h) and LY294002, or phorbol ester (24 h) and pertussis toxin (PTX).	Phorbol Esters	146-159	sphingosine-1-phosphate receptor 1	Mus musculus	4-7
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	Cyclic AMP	218-228	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11467306-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	Cyclic AMP	218-228	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	107-115	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11467306-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Inositol Phosphates	42-61	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11467306-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Calcium	90-97	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11467306-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Thapsigargin	119-131	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11467306-13	2001	Probably, Gi/Go protein activation and phosphoinositide hydrolysis are early events that regulate the activation of Erks by S1P.	Phosphatidylinositols	39-55	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	Cyclic AMP	218-228	sphingosine-1-phosphate receptor 1	Mus musculus	39-42
11422447-10	2001	In contrast, the stimulatory effect of S1P on astrocyte proliferation was totally blocked by either PTX or LY294002, but not by a downregulation of protein kinase C. S1P dramatically inhibited the evoked production of cyclic AMP, a response that was impaired by PTX.	Cyclic AMP	218-228	sphingosine-1-phosphate receptor 1	Mus musculus	166-169
11422447-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Inositol Phosphates	42-61	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11422447-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Calcium	90-97	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11422447-11	2001	Finally, S1P stimulated the production of inositol phosphates and increased intracellular calcium by mobilization from thapsigargin-sensitive stores.	Thapsigargin	119-131	sphingosine-1-phosphate receptor 1	Mus musculus	9-12
11422447-13	2001	Probably, Gi/Go protein activation and phosphoinositide hydrolysis are early events that regulate the activation of Erks by S1P.	Phosphatidylinositols	39-55	sphingosine-1-phosphate receptor 1	Mus musculus	124-127
10544002-1	1999	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite abundantly stored in platelets and released upon platelet activation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11284444-1	2001	Sphingosine-1-phosphate (S1P) is a phospholipid that acts through G-protein-coupled plasma membrane receptors and induces a broad spectrum of cellular responses, including proliferation, migration, differentiation and apoptosis.	Phospholipids	35-47	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
11284444-2	2001	Here we report that in NIH3T3 and C3H10T1/2 mouse fibroblasts S1P activates a Ca2+-dependent, voltage-independent K+ current (EC50-value 113 nM) that is blocked by the K+ channel blockers charybdotoxin, margatoxin, and iberiotoxin.	Charybdotoxin	188-201	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
11284444-2	2001	Here we report that in NIH3T3 and C3H10T1/2 mouse fibroblasts S1P activates a Ca2+-dependent, voltage-independent K+ current (EC50-value 113 nM) that is blocked by the K+ channel blockers charybdotoxin, margatoxin, and iberiotoxin.	iberiotoxin	219-230	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
11284444-4	2001	Recently, we showed that lysophosphatidic acid (LPA), a serum lipid with similar biological effects compared to those of S1P, can activate a Ca2+-dependent K+ current in NIH3T3 cells that has identical properties compared to the one that is activated by S1P.	lysophosphatidic acid	25-46	sphingosine-1-phosphate receptor 1	Mus musculus	121-124
11284444-4	2001	Recently, we showed that lysophosphatidic acid (LPA), a serum lipid with similar biological effects compared to those of S1P, can activate a Ca2+-dependent K+ current in NIH3T3 cells that has identical properties compared to the one that is activated by S1P.	lysophosphatidic acid	25-46	sphingosine-1-phosphate receptor 1	Mus musculus	254-257
11284444-4	2001	Recently, we showed that lysophosphatidic acid (LPA), a serum lipid with similar biological effects compared to those of S1P, can activate a Ca2+-dependent K+ current in NIH3T3 cells that has identical properties compared to the one that is activated by S1P.	lysophosphatidic acid	48-51	sphingosine-1-phosphate receptor 1	Mus musculus	254-257
11036869-8	2000	Two microM U73122 (phospholipase C inhibitor) completely deleted 10 microM S1P-induced stimulation of insulin secretion for 10 minutes, but U73343 (an inactive analogue of U73122) did not.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	11-17	sphingosine-1-phosphate receptor 1	Mus musculus	75-78
11036869-9	2000	S1P dose-dependently inhibited intracellular cyclic AMP levels.	Cyclic AMP	45-55	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
11036869-11	2000	These data suggested that PTX-sensitive G-protein-dependent pathway may, at least in part, be involved in an increase of non-glucose stimulated insulin secretion by S1P through the activation of phospholipase C-Ca2+ system.	Glucose	125-132	sphingosine-1-phosphate receptor 1	Mus musculus	165-168
10544002-1	1999	Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite abundantly stored in platelets and released upon platelet activation.	Sphingolipids	45-57	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
10544002-9	1999	Further, the MEK inhibitor U0126 markedly inhibited S1P-induced tube formation but S1P-induced migration was not affected by inhibition of ERK and p38 MAPK.	U 0126	27-32	sphingosine-1-phosphate receptor 1	Mus musculus	52-55
10334873-7	1999	Ethanol-plus-S1P-induced DNA synthesis was partially inhibited by both PD 98059 (50 microM) and rapamycin (10 nM), inhibitors of p42/p44 MAP kinase kinase and mTOR/p70 S6 kinases, respectively.	Ethanol	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
10334873-1	1999	In mouse embryo NIH 3T3 fibroblasts, ethanol (60-80 mM) was found to enhance the stimulatory effects of sphingosine 1-phosphate (S1P) on both DNA synthesis and cell proliferation.	Ethanol	37-44	sphingosine-1-phosphate receptor 1	Mus musculus	129-132
10334873-7	1999	Ethanol-plus-S1P-induced DNA synthesis was partially inhibited by both PD 98059 (50 microM) and rapamycin (10 nM), inhibitors of p42/p44 MAP kinase kinase and mTOR/p70 S6 kinases, respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	71-79	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
10334873-2	1999	Well-detectable potentiating effects of ethanol on S1P-induced mitogenesis required the presence of calcium (&gt;1 mM) and zinc (20-40 microM) in the incubation medium.	Ethanol	40-47	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
10334873-7	1999	Ethanol-plus-S1P-induced DNA synthesis was partially inhibited by both PD 98059 (50 microM) and rapamycin (10 nM), inhibitors of p42/p44 MAP kinase kinase and mTOR/p70 S6 kinases, respectively.	Sirolimus	96-105	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
10334873-2	1999	Well-detectable potentiating effects of ethanol on S1P-induced mitogenesis required the presence of calcium (&gt;1 mM) and zinc (20-40 microM) in the incubation medium.	Calcium	100-107	sphingosine-1-phosphate receptor 1	Mus musculus	51-54
10334873-3	1999	The amphibian tetrapeptide bombesin, which is known to mobilize intracellular calcium in fibroblasts, had no effect alone, but it approximately doubled the combined stimulatory effects of ethanol and S1P on DNA synthesis.	Calcium	78-85	sphingosine-1-phosphate receptor 1	Mus musculus	200-203
10334873-8	1999	The results indicate that in NIH 3T3 fibroblasts, ethanol can enhance the mitogenic effects of S1P by a zinc- and calcium-dependent mechanism involving both the rapamycin-sensitive p70 S6 kinase-dependent and the c-Raf-1/MAP kinase-dependent growth regulatory pathways.	Ethanol	50-57	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
10334873-4	1999	The synergistic mitogenic effects of ethanol and S1P were also slightly enhanced, rather than inhibited, by the alcohol dehydrogenase inhibitor 4-methylpyrazole (5 mM).	Fomepizole	144-160	sphingosine-1-phosphate receptor 1	Mus musculus	49-52
10334873-8	1999	The results indicate that in NIH 3T3 fibroblasts, ethanol can enhance the mitogenic effects of S1P by a zinc- and calcium-dependent mechanism involving both the rapamycin-sensitive p70 S6 kinase-dependent and the c-Raf-1/MAP kinase-dependent growth regulatory pathways.	Calcium	114-121	sphingosine-1-phosphate receptor 1	Mus musculus	95-98
10334873-5	1999	Of the various growth regulatory enzymes examined, ethanol detectably enhanced the stimulatory effects of S1P on the phosphosphorylation (activation) of p42/p44 mitogen-activated protein (MAP) kinases, but not of p38 MAP kinase.	Ethanol	51-58	sphingosine-1-phosphate receptor 1	Mus musculus	106-109
10334873-6	1999	Cotreatment of fibroblasts with ethanol for 10 min also enhanced the stimulatory effects of S1P on the activities of c-Raf-1 kinase and p70 S6 kinase, but neither S1P nor ethanol had effects on phosphatidylinositol 3"-kinase and Akt/PKB kinase activities.	Ethanol	32-39	sphingosine-1-phosphate receptor 1	Mus musculus	92-95
33807180-1	2021	Sphingosine kinase-1 (Sphk1) and its product, sphingosine-1-phosphate (S1P) are important regulators of cardiac growth and function.	sphingosine 1-phosphate	46-69	sphingosine-1-phosphate receptor 1	Mus musculus	71-74
33940233-2	2021	Here, we evaluated whether ponesimod, an S1P1 modulator, affects inflammation in experimental autoimmune encephalomyelitis (EAE) and investigated Th1/Th2/Th17/Treg cell subsets.	ponesimod	27-36	sphingosine-1-phosphate receptor 1	Mus musculus	41-45
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	sphingosine 1-phosphate	43-66	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	phosphatidylethanolamine	121-145	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	Water	189-194	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
9371692-1	1997	In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells.	Ethanolamine	133-145	sphingosine-1-phosphate receptor 1	Mus musculus	68-71
9371692-2	1997	In [14C]ethanolamine-labelled cells, S1P (0.5-5 microM) stimulated PLD-mediated hydrolysis of PtdEtn 1.5-2.1-fold.	Carbon-14	4-7	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
9371692-2	1997	In [14C]ethanolamine-labelled cells, S1P (0.5-5 microM) stimulated PLD-mediated hydrolysis of PtdEtn 1.5-2.1-fold.	Ethanolamine	8-20	sphingosine-1-phosphate receptor 1	Mus musculus	37-40
9371692-4	1997	S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.	Phosphorylcholine	80-94	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
9371692-4	1997	S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.	Phosphorylcholine	96-100	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
9371692-4	1997	S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.	Adenosine Triphosphate	112-115	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
9371692-4	1997	S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.	Tetradecanoylphorbol Acetate	119-122	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
9371692-6	1997	In contrast, 5-20 microM concentrations of ethanolamine, which correspond to normal blood ethanolamine levels in humans, strongly inhibited DNA synthesis induced by S1P plus PCho via a MAP kinase-dependent mechanism; importantly, less or no inhibition was observed with 50-100 microM concentrations of ethanolamine.	Ethanolamine	43-55	sphingosine-1-phosphate receptor 1	Mus musculus	165-168
9371692-7	1997	At 5-50 microM concentrations, ethanolamine also inhibited the synergistic mitogenic effects of both S1P plus insulin (22-27% inhibition) and PCho plus ATP (45-73% inhibition) but not those of S1P plus PMA or S1P plus ATP.	Ethanolamine	31-43	sphingosine-1-phosphate receptor 1	Mus musculus	101-104
9371692-9	1997	Increased formation of ethanolamine by PLD-mediated PtdEtn hydrolysis or by other means may be required for maximal stimulation of DNA synthesis by S1P in the presence of insulin, and particularly PCho.	Ethanolamine	23-35	sphingosine-1-phosphate receptor 1	Mus musculus	148-151
8665846-1	1996	Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid implicated in mitogenesis and cytoskeletal remodelling, but its mechanism of action is poorly understood.	Sphingolipids	45-61	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
8665846-2	1996	We report here that in N1E-115 neuronal cells, S1P mimics the G protein-coupled receptor agonist lysophosphatidic acid (LPA) in rapidly inducing neurite retraction and soma rounding, a process driven by Rho-dependent contraction of the actin cytoskeleton.	lysophosphatidic acid	97-118	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
8665846-2	1996	We report here that in N1E-115 neuronal cells, S1P mimics the G protein-coupled receptor agonist lysophosphatidic acid (LPA) in rapidly inducing neurite retraction and soma rounding, a process driven by Rho-dependent contraction of the actin cytoskeleton.	lysophosphatidic acid	120-123	sphingosine-1-phosphate receptor 1	Mus musculus	47-50
8665846-3	1996	S1P is approximately 100-fold more potent than LPA in evoking these shape changes, with an EC50 as low as 1.5 nM.	lysophosphatidic acid	47-50	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
8665846-5	1996	As with LPA, S1P action is inhibited by suramin and subject to homologous desensitization; however, the responses to S1P and LPA do not show cross-desensitization.	Suramin	40-47	sphingosine-1-phosphate receptor 1	Mus musculus	13-16
8665846-7	1996	Thus, S1P and LPA may belong to an emerging family of bioactive lysophospholipids that act through distinct G protein-coupled receptors to mediate similar actions.	Lysophospholipids	64-81	sphingosine-1-phosphate receptor 1	Mus musculus	6-9
34815755-5	2022	Expressions of sphingosine-1-phosphate (S1P) receptors (S1PR)1-4 and protease-activated receptor 1 (PAR1) were measured by reverse transcription-quantitative PCR and western blotting in mice with UUO and TGF-beta induced HK-2 cells.	sphingosine 1-phosphate	15-38	sphingosine-1-phosphate receptor 1	Mus musculus	56-64
34798130-0	2022	Sphingosine-1-phosphate receptor 1 agonist SEW2871 alters membrane properties of late-firing somatostatin expressing neurons in the central lateral amygdala.	SEW2871	43-50	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
34535564-1	2021	Ozanimod, a sphingosine-1 phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), is approved for the treatment of relapsing multiple sclerosis (MS) in multiple countries.	ozanimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	106-129
34855990-6	2021	Mitogenic factor, sphingosine-1-phosphate (S1P) was increased in congestive liver and expression of sphingosine kinase 1 (SphK1), a major synthetase of S1P, was increased in capillarized LSECs after pIVCL.	sphingosine 1-phosphate	18-41	sphingosine-1-phosphate receptor 1	Mus musculus	43-46
34109517-0	2021	Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.	Ethanol	92-99	sphingosine-1-phosphate receptor 1	Mus musculus	19-24
34109517-2	2021	Therefore, this study aimed to explore whether sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor 1 (S1PR1) signaling pathway functions in lung injury caused by acute ethanol intoxication-enhanced sepsis, as well as its underlying mechanism.	sphingosine 1-phosphate	76-99	sphingosine-1-phosphate receptor 1	Mus musculus	106-120
34109517-2	2021	Therefore, this study aimed to explore whether sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor 1 (S1PR1) signaling pathway functions in lung injury caused by acute ethanol intoxication-enhanced sepsis, as well as its underlying mechanism.	sphingosine 1-phosphate	76-99	sphingosine-1-phosphate receptor 1	Mus musculus	122-127
34109517-2	2021	Therefore, this study aimed to explore whether sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor 1 (S1PR1) signaling pathway functions in lung injury caused by acute ethanol intoxication-enhanced sepsis, as well as its underlying mechanism.	Ethanol	188-195	sphingosine-1-phosphate receptor 1	Mus musculus	106-120
34109517-2	2021	Therefore, this study aimed to explore whether sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor 1 (S1PR1) signaling pathway functions in lung injury caused by acute ethanol intoxication-enhanced sepsis, as well as its underlying mechanism.	Ethanol	188-195	sphingosine-1-phosphate receptor 1	Mus musculus	122-127
34109517-10	2021	In addition, EtOH could activate the SphK1/S1P/S1PR1 pathway in CLP mice.	Ethanol	13-17	sphingosine-1-phosphate receptor 1	Mus musculus	47-52
34474613-7	2022	Selective S1P receptor 3 antagonist TY 52156 markedly reduced both MCA vasoconstriction induced by exogenous S1P and arachnoid-dependent basal tone increase.	1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone	36-44	sphingosine-1-phosphate receptor 1	Mus musculus	109-112
34911793-1	2022	BACKGROUND AND OBJECTIVES: To investigate whether the formation or retention of meningeal ectopic lymphoid tissue (mELT) can be inhibited by the sphingosine 1-phosphate receptor 1,5 modulator siponimod (BAF312) in a murine model of multiple sclerosis (MS).	siponimod	192-201	sphingosine-1-phosphate receptor 1	Mus musculus	145-179
34911793-1	2022	BACKGROUND AND OBJECTIVES: To investigate whether the formation or retention of meningeal ectopic lymphoid tissue (mELT) can be inhibited by the sphingosine 1-phosphate receptor 1,5 modulator siponimod (BAF312) in a murine model of multiple sclerosis (MS).	siponimod	203-209	sphingosine-1-phosphate receptor 1	Mus musculus	145-179
34535564-6	2021	Hence, in the experimental autoimmune encephalomyelitis model, ozanimod exposures sufficient to engage S1P1, but not S1P5, resulted in reduced circulating lymphocytes, disease scores, and body weight loss; reduced inflammation, demyelination, and apoptotic cell counts in the spinal cord; and reduced circulating levels of the neuronal degeneration marker, neurofilament light.	ozanimod	63-71	sphingosine-1-phosphate receptor 1	Mus musculus	103-107
34535564-10	2021	Ozanimod can thus be used as a selective S1P1 agonist in mouse models of multiple sclerosis to define efficacies driven by S1P1 but not S1P5 Based on readouts for experimental autoimmune encephalomyelitis and cuprizone intoxication, S1P1 modulation is neuroprotective but S1P5 activity may be required for remyelination.	ozanimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	41-45
34535564-10	2021	Ozanimod can thus be used as a selective S1P1 agonist in mouse models of multiple sclerosis to define efficacies driven by S1P1 but not S1P5 Based on readouts for experimental autoimmune encephalomyelitis and cuprizone intoxication, S1P1 modulation is neuroprotective but S1P5 activity may be required for remyelination.	ozanimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	233-237
34535564-1	2021	Ozanimod, a sphingosine-1 phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), is approved for the treatment of relapsing multiple sclerosis (MS) in multiple countries.	ozanimod	0-8	sphingosine-1-phosphate receptor 1	Mus musculus	131-135
34535564-1	2021	Ozanimod, a sphingosine-1 phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), is approved for the treatment of relapsing multiple sclerosis (MS) in multiple countries.	sphingosine 1-phosphate	12-35	sphingosine-1-phosphate receptor 1	Mus musculus	106-129
34534447-3	2021	Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR1) on CD82KO HSPCs.	plerixafor	138-145	sphingosine-1-phosphate receptor 1	Mus musculus	222-256
34839819-3	2021	Cenerimod, a potent, selective and orally active sphingosine-1-phosphate receptor 1 modulator, inhibits the egress of lymphocytes into the circulation.	jervine	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	49-83
34858827-6	2021	In addition, the caerin gel treatment recruits almost two-fold more activated CD8+ T cells to the TME, relative to the untreated tumour, which shows a synergistic effect derived from the regulation of S1pr1, Ccr7, Ms4a4b and Gimap family expression.	caerin	17-23	sphingosine-1-phosphate receptor 1	Mus musculus	201-206
34561229-7	2021	Specifically, CD69-independent increases in sphingosine-1-phosphate (S1P) receptor 1-negative naive and central memory T cells occurred in these lymph nodes.	sphingosine 1-phosphate	44-67	sphingosine-1-phosphate receptor 1	Mus musculus	69-84
34534447-3	2021	Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR1) on CD82KO HSPCs.	plerixafor	138-145	sphingosine-1-phosphate receptor 1	Mus musculus	258-263
34542010-3	2021	Here, we consider whether the sphingosine-1-phosphate (S1P) pathway could constitute such a route.	sphingosine 1-phosphate	30-53	sphingosine-1-phosphate receptor 1	Mus musculus	55-58
34934406-8	2021	Ex vivo biodistribution data showed that the uptake of (18F)TZ4877 was increased 30.6%, 54.3%, 74.3%, and 115.3% in the liver, kidney, pancreas, and thymus of the infected mice, respectively, compared to that in normal control mice, indicating that S1PR1 is involved in the early immune response to bacterial infection.	tz4877	60-66	sphingosine-1-phosphate receptor 1	Mus musculus	249-254
34934406-9	2021	NIBR-0213 or S1PR1-specific DsiRNA pretreatment reduced the tissue uptake of (18F)TZ4877, suggesting that uptake of (18F)TZ4877 is specific.	tz4877	82-88	sphingosine-1-phosphate receptor 1	Mus musculus	13-18
34934406-9	2021	NIBR-0213 or S1PR1-specific DsiRNA pretreatment reduced the tissue uptake of (18F)TZ4877, suggesting that uptake of (18F)TZ4877 is specific.	tz4877	121-127	sphingosine-1-phosphate receptor 1	Mus musculus	13-18
34934406-11	2021	Particularly, compared to control mice, a 39% increase of (18F)TZ4877 uptake was observed in the infected muscle of S. aureus mice, indicating that S1PR1 expression was directly involved in the inflammatory response to infection.	tz4877	63-69	sphingosine-1-phosphate receptor 1	Mus musculus	148-153
34934406-14	2021	PET with S1PR1-specific radiotracer (18F)TZ4877 could provide a noninvasive tool for detecting the early S1PR1 immune response to infectious diseases.	tz4877	41-47	sphingosine-1-phosphate receptor 1	Mus musculus	9-14
34934406-14	2021	PET with S1PR1-specific radiotracer (18F)TZ4877 could provide a noninvasive tool for detecting the early S1PR1 immune response to infectious diseases.	tz4877	41-47	sphingosine-1-phosphate receptor 1	Mus musculus	105-110
34934406-5	2021	The changes of S1PR1 expression in response to bacterial infection and blocking treatment were assessed using ex vivo biodistribution and in vivo positron emission tomography (PET) after intravenous injection of an S1PR1-specific radiotracer (18F)TZ4877.	tz4877	247-253	sphingosine-1-phosphate receptor 1	Mus musculus	15-20
34934406-5	2021	The changes of S1PR1 expression in response to bacterial infection and blocking treatment were assessed using ex vivo biodistribution and in vivo positron emission tomography (PET) after intravenous injection of an S1PR1-specific radiotracer (18F)TZ4877.	tz4877	247-253	sphingosine-1-phosphate receptor 1	Mus musculus	215-220
34603029-9	2021	Diabetic animals treated with fingolimod plus Ex 26 (S1PR1 selective blocker) had VEGFR1, VEGFR2, and VEGFA levels between diabetic mice group and the group of diabetic mice treated with fingolimod alone.	Fingolimod Hydrochloride	30-40	sphingosine-1-phosphate receptor 1	Mus musculus	53-58
34638955-1	2021	Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
34638955-1	2021	Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
34638955-1	2021	Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation.	Sphingolipids	116-128	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
34638955-1	2021	Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation.	Sphingolipids	116-128	sphingosine-1-phosphate receptor 1	Mus musculus	83-86
34352381-4	2021	Sphingosine-1-phosphate (S1P) is a central bioactive lipid of sphingolipid metabolism, which serves a pivotal role in regulating numerous physiological and pathological processes.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	25-28
34603029-1	2021	This study aimed to investigate the interactions between fingolimod, a sphingosine 1-phosphate receptor (S1PR) agonist, and melanocortin receptors 1 and 5 (MCR1, MCR5).	Fingolimod Hydrochloride	57-67	sphingosine-1-phosphate receptor 1	Mus musculus	105-109
34603029-1	2021	This study aimed to investigate the interactions between fingolimod, a sphingosine 1-phosphate receptor (S1PR) agonist, and melanocortin receptors 1 and 5 (MCR1, MCR5).	sphingosine 1-phosphate	71-94	sphingosine-1-phosphate receptor 1	Mus musculus	105-109
34603029-9	2021	Diabetic animals treated with fingolimod plus Ex 26 (S1PR1 selective blocker) had VEGFR1, VEGFR2, and VEGFA levels between diabetic mice group and the group of diabetic mice treated with fingolimod alone.	Fingolimod Hydrochloride	187-197	sphingosine-1-phosphate receptor 1	Mus musculus	53-58
34484174-1	2021	Sphingosine-1-phosphate (S1P) is a phospholipid that regulates pleiotropic biological activities and exerts extracellular functions by binding to five specific G-protein-coupled receptors, S1P receptors (S1PR) 1-5.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	204-211
34415189-11	2021	Furthermore, selective S1P1 agonist limited inflammatory markers CCL2 and TNF-alpha and accelerated reparative markers ARG-1 and YM-1 in macrophages in the presence of Kdo2-Lipid A (KLA; potent inflammatory stimulant).	Kdo2-lipid A	168-180	sphingosine-1-phosphate receptor 1	Mus musculus	23-27
34415189-11	2021	Furthermore, selective S1P1 agonist limited inflammatory markers CCL2 and TNF-alpha and accelerated reparative markers ARG-1 and YM-1 in macrophages in the presence of Kdo2-Lipid A (KLA; potent inflammatory stimulant).	Kdo2-lipid A	182-185	sphingosine-1-phosphate receptor 1	Mus musculus	23-27
34502385-3	2021	In this study, we used the immortalized renal interstitial fibroblast cell line FAIK F3-5 to investigate the ability of the bioactive sphingolipid sphingosine 1-phosphate (S1P) to stimulate Epo production and to reveal the mechanism involved.	sphingosine 1-phosphate	147-170	sphingosine-1-phosphate receptor 1	Mus musculus	172-175
34502385-4	2021	Stimulation of cells with exogenous S1P under normoxic conditions (21% O2) led to a dose-dependent increase in Epo mRNA and protein levels and subsequent release of Epo into the medium.	Oxygen	71-73	sphingosine-1-phosphate receptor 1	Mus musculus	36-39
34502385-7	2021	Furthermore, the approved S1P receptor modulator FTY720, and its active form FTY720-phosphate, both exerted a similar effect on Epo expression as S1P.	Fingolimod Hydrochloride	49-55	sphingosine-1-phosphate receptor 1	Mus musculus	26-29
34502385-8	2021	The effect of S1P on Epo was antagonized by the selective S1P1 and S1P3 antagonists NIBR-0213 and TY-52156, but not by the S1P2 antagonist JTE-013.	NIBR-0213	84-93	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
34502385-8	2021	The effect of S1P on Epo was antagonized by the selective S1P1 and S1P3 antagonists NIBR-0213 and TY-52156, but not by the S1P2 antagonist JTE-013.	NIBR-0213	84-93	sphingosine-1-phosphate receptor 1	Mus musculus	58-62
34502385-8	2021	The effect of S1P on Epo was antagonized by the selective S1P1 and S1P3 antagonists NIBR-0213 and TY-52156, but not by the S1P2 antagonist JTE-013.	1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone	98-106	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
34500564-0	2021	ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo.	st-2191	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	82-86
34500564-0	2021	ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo.	oxy-fingolimod	50-64	sphingosine-1-phosphate receptor 1	Mus musculus	82-86
34500564-3	2021	S1P1 modulators, such as fingolimod, disrupt this recycling by inducing persistent S1P1 internalization and receptor degradation, which results in blocked egress of T cells from the secondary lymphoid tissues.	Fingolimod Hydrochloride	25-35	sphingosine-1-phosphate receptor 1	Mus musculus	0-4
34500564-3	2021	S1P1 modulators, such as fingolimod, disrupt this recycling by inducing persistent S1P1 internalization and receptor degradation, which results in blocked egress of T cells from the secondary lymphoid tissues.	Fingolimod Hydrochloride	25-35	sphingosine-1-phosphate receptor 1	Mus musculus	83-87
34500564-5	2021	Here, we report on a novel anellated bismorpholino derivative of oxy-fingolimod, named ST-2191, which exerts selective S1P1 agonist and functional antagonist potency.	bismorpholino	37-50	sphingosine-1-phosphate receptor 1	Mus musculus	119-123
34500564-5	2021	Here, we report on a novel anellated bismorpholino derivative of oxy-fingolimod, named ST-2191, which exerts selective S1P1 agonist and functional antagonist potency.	oxy-fingolimod	65-79	sphingosine-1-phosphate receptor 1	Mus musculus	119-123
34500564-5	2021	Here, we report on a novel anellated bismorpholino derivative of oxy-fingolimod, named ST-2191, which exerts selective S1P1 agonist and functional antagonist potency.	st-2191	87-94	sphingosine-1-phosphate receptor 1	Mus musculus	119-123
34502385-8	2021	The effect of S1P on Epo was antagonized by the selective S1P1 and S1P3 antagonists NIBR-0213 and TY-52156, but not by the S1P2 antagonist JTE-013.	1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone	98-106	sphingosine-1-phosphate receptor 1	Mus musculus	58-62
34484174-1	2021	Sphingosine-1-phosphate (S1P) is a phospholipid that regulates pleiotropic biological activities and exerts extracellular functions by binding to five specific G-protein-coupled receptors, S1P receptors (S1PR) 1-5.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	204-211
34484174-9	2021	Reduced uptake of 99mTc-HYNIC-S1PR1mAb in SK-HEP-1 was observed in tumor-bearing nude mice pretreated with fingolimod, which binds competitively to the receptors, especially S1PR1.	Technetium	18-23	sphingosine-1-phosphate receptor 1	Mus musculus	30-35
34484174-9	2021	Reduced uptake of 99mTc-HYNIC-S1PR1mAb in SK-HEP-1 was observed in tumor-bearing nude mice pretreated with fingolimod, which binds competitively to the receptors, especially S1PR1.	Technetium	18-23	sphingosine-1-phosphate receptor 1	Mus musculus	174-179
34484174-9	2021	Reduced uptake of 99mTc-HYNIC-S1PR1mAb in SK-HEP-1 was observed in tumor-bearing nude mice pretreated with fingolimod, which binds competitively to the receptors, especially S1PR1.	Fingolimod Hydrochloride	107-117	sphingosine-1-phosphate receptor 1	Mus musculus	30-35
34484174-9	2021	Reduced uptake of 99mTc-HYNIC-S1PR1mAb in SK-HEP-1 was observed in tumor-bearing nude mice pretreated with fingolimod, which binds competitively to the receptors, especially S1PR1.	Fingolimod Hydrochloride	107-117	sphingosine-1-phosphate receptor 1	Mus musculus	174-179
35406433-1	2022	Sphingosine 1-phosphate (S1P), a bioactive lipid, interacts with five widely expressed G protein-coupled receptors (S1P1-5), regulating a variety of downstream signaling pathways with overlapping but also opposing functions.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	116-122
34177891-10	2021	FTY720 treatment in the absence of EAE resulted in overall downregulation of S1PR1 and S1PR3, while S1PR5 exhibited a dose-dependent upregulation.	Fingolimod Hydrochloride	0-6	sphingosine-1-phosphate receptor 1	Mus musculus	77-82
35609189-1	2022	Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways.	sphingosine 1-phosphate	0-23	sphingosine-1-phosphate receptor 1	Mus musculus	120-126
35609189-1	2022	Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	120-126
35354603-1	2022	BACKGROUND AND OBJECTIVES: Siponimod is an oral, selective sphingosine-1-phosphate receptor-1/5 modulator approved for treatment of multiple sclerosis.	siponimod	27-36	sphingosine-1-phosphate receptor 1	Mus musculus	59-95
34343038-0	2022	Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-Induced Pulmonary Fibrosis.	Bleomycin	112-121	sphingosine-1-phosphate receptor 1	Mus musculus	29-63
34343038-8	2022	Following a low dose intratracheal bleomycin challenge, EC-S1pr1-/- mice had increased and persistent vascular permeability compared to wild-type mice, which was strongly correlated with the amount and localization of resulting pulmonary fibrosis.	Bleomycin	35-44	sphingosine-1-phosphate receptor 1	Mus musculus	59-64
35406433-1	2022	Sphingosine 1-phosphate (S1P), a bioactive lipid, interacts with five widely expressed G protein-coupled receptors (S1P1-5), regulating a variety of downstream signaling pathways with overlapping but also opposing functions.	sphingosine 1-phosphate	25-28	sphingosine-1-phosphate receptor 1	Mus musculus	116-122
35077170-2	2022	We designed and synthesized triazole and isoxazoline derivatives to discover a novel S1P1 agonist for MS treatment.	Triazoles	28-36	sphingosine-1-phosphate receptor 1	Mus musculus	85-89
35077170-2	2022	We designed and synthesized triazole and isoxazoline derivatives to discover a novel S1P1 agonist for MS treatment.	Isoxazoline	41-52	sphingosine-1-phosphate receptor 1	Mus musculus	85-89
35173110-0	2022	MiR-363-3p/S1PR1 axis inhibits sepsis-induced acute lung injury via the inactivation of NF-kappaB signaling.	mir-363	0-7	sphingosine-1-phosphate receptor 1	Mus musculus	11-16
35144528-0	2022	Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model.	Nitroglycerin	85-98	sphingosine-1-phosphate receptor 1	Mus musculus	0-34
35173110-7	2022	Downregulation of miR-363-3p suppressed sphingosine-1-phosphate receptor 1 (S1PR1) expression in lung tissues and subsequently inactivated the nuclear factor kappa-B ligand (NF-kappaB) signaling.	mir-363-3p	18-28	sphingosine-1-phosphate receptor 1	Mus musculus	40-74
35173110-7	2022	Downregulation of miR-363-3p suppressed sphingosine-1-phosphate receptor 1 (S1PR1) expression in lung tissues and subsequently inactivated the nuclear factor kappa-B ligand (NF-kappaB) signaling.	mir-363-3p	18-28	sphingosine-1-phosphate receptor 1	Mus musculus	76-81
35144528-10	2022	RESULTS: Our results showed that the expression of S1PR1 was increased after NTG injection and S1PR1 was colocalized with in neurons and glial cells in the TCC.	Nitroglycerin	77-80	sphingosine-1-phosphate receptor 1	Mus musculus	51-56
35144528-11	2022	The S1PR1 antagonist W146 alleviated NTG-induced hyperalgesia and suppressed the upregulation of CGRP, c-fos and pSTAT3 in the TCC.	W146	21-25	sphingosine-1-phosphate receptor 1	Mus musculus	4-9
35144528-14	2022	CONCLUSIONS: Our results indicate that inhibiting S1PR1 signal could alleviate central sensitization and inhibit microglia activity caused by chronic NTG administration via STAT3 signal pathway, which provide a new clue for the clinical treatment of CM.	Nitroglycerin	150-153	sphingosine-1-phosphate receptor 1	Mus musculus	50-55
35055052-11	2022	CFTR correction with C18 attenuated the HF-associated alterations in pulmonary CFTR expression and, hence, led to lower pulmonary S1P levels, which was accompanied by reduced lung inflammation.	1-octadecene	21-24	sphingosine-1-phosphate receptor 1	Mus musculus	130-133
34986275-4	2022	Studies confirmed ponesimod"s selectivity for S1P1 without comparable engagement to the other S1PR subtypes (S1P2,3,4,5 ).	ponesimod	18-27	sphingosine-1-phosphate receptor 1	Mus musculus	46-50
34986275-5	2022	Ponesimod showed pharmacological properties of acute agonism followed by chronic functional antagonism of S1P1 .	ponesimod	0-9	sphingosine-1-phosphate receptor 1	Mus musculus	106-110