PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33960248-8	2021	Implant avoids between 0.75% and 3.53% additional UP per person-year compared to copper IUD and second generation COC, respectively, with an ICER of $2,221 per UP avoided compared to copper IUD.	Cocaine	114-117	cAMP responsive element modulator	Homo sapiens	141-145
32844453-8	2021	Letermovir use for cytomegalovirus prophylaxis was a cost-effective option versus no prophylaxis with base-case analysis ICER $25,046/QALY gained.	letermovir	0-10	cAMP responsive element modulator	Homo sapiens	121-125
32844453-10	2021	The probabilistic sensitivity analysis showed a 92% probability of letermovir producing an ICER below the commonly accepted willingness-to-pay threshold of $100,000/QALY gained.	letermovir	67-77	cAMP responsive element modulator	Homo sapiens	91-95
33879168-7	2021	RESULTS: Imrecoxib was highly cost-effective than diclofenac (the ICER was $401.58 and $492.77 in patients at low and high gastrointestinal and cardiovascular risk, respectively).	Imrecoxib	9-18	cAMP responsive element modulator	Homo sapiens	66-70
33620750-12	2021	The optimal strategy was DAAs+50% HR (ICER $6743/DALY averted compared to DAAs only) under the one-time per capita GDP WTP ($9,698).	daas	25-29	cAMP responsive element modulator	Homo sapiens	38-42
33615360-19	2021	The ICER of Letrozole versus CC was $2809 per additional live birth, whereas the ICER of gonadotrophins versus Letrozole was $53 831 per additional live birth.	Letrozole	12-21	cAMP responsive element modulator	Homo sapiens	4-8
33620750-12	2021	The optimal strategy was DAAs+50% HR (ICER $6743/DALY averted compared to DAAs only) under the one-time per capita GDP WTP ($9,698).	gdp wtp	115-122	cAMP responsive element modulator	Homo sapiens	38-42
33119438-0	2020	ICER"s assessment of lasmiditan, rimegepant, and ubrogepant for acute migraine.	lasmiditan	21-31	cAMP responsive element modulator	Homo sapiens	0-4
32800910-9	2021	RESULTS: The increased cost of dapagliflozin add-on treatment from 17,442 THB (559 USD) to 54,405 THB (1745 USD) was associated with a QALY gain from 6.33 to 6.92 compared to standard therapy, yielding an ICER of 62,090 THB/QALY (1991 USD/QALY).	dapagliflozin	31-44	cAMP responsive element modulator	Homo sapiens	205-209
33474817-12	2021	The ICER of screen-and-test compared to EID was $1340/YLS (CI), $650/YLS (SA) and $670/YLS (Zimbabwe), below the per-capita GDP but above the ICER of 2 versus 1 lifetime ART regimens in all countries.	Guanosine Diphosphate	124-127	cAMP responsive element modulator	Homo sapiens	4-8
33295974-17	2020	In the case of a patient with a BRCA variant, olaparib was the most cost-effective (ICER, $186 777/PF-LYS).	olaparib	46-54	cAMP responsive element modulator	Homo sapiens	84-88
33295974-19	2020	Olaparib-bevacizumab was the most cost-effective in the case of a patient with homologous recombination deficiency without a BRCA variant (ICER, $629 347/PF-LYS), and bevacizumab was the most cost-effective in the case of patient with homologous recombination proficiency (ICER, $557 865/PF-LYS).	olaparib	0-8	cAMP responsive element modulator	Homo sapiens	139-143
33295974-19	2020	Olaparib-bevacizumab was the most cost-effective in the case of a patient with homologous recombination deficiency without a BRCA variant (ICER, $629 347/PF-LYS), and bevacizumab was the most cost-effective in the case of patient with homologous recombination proficiency (ICER, $557 865/PF-LYS).	olaparib	0-8	cAMP responsive element modulator	Homo sapiens	273-277
32656632-9	2020	RESULTS: The discounted ICER for inpatient BKP vs. CMM was $43,455 per QALY gained; for outpatient BKP vs. CMM, $10,922; for inpatient VP vs. CMM, $39,774; and for outpatient VP vs. CMM, $12,293.	5'-O-[(S)-hydroxy{[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine	43-46	cAMP responsive element modulator	Homo sapiens	24-28
33119438-0	2020	ICER"s assessment of lasmiditan, rimegepant, and ubrogepant for acute migraine.	ubrogepant	49-59	cAMP responsive element modulator	Homo sapiens	0-4
33119438-0	2020	ICER"s assessment of lasmiditan, rimegepant, and ubrogepant for acute migraine.	rimegepant sulfate	33-43	cAMP responsive element modulator	Homo sapiens	0-4
32037675-6	2020	RESULTS: Dapagliflozin 5 mg was associated with gains of 0.23 life years and 0.42 QALYs, at an additional cost of $4,240 per person; corresponding to an ICER of $10,143 versus standard of care.	dapagliflozin	9-22	cAMP responsive element modulator	Homo sapiens	153-157
32518952-6	2020	However, using ibrutinib in the first-line led to significantly higher healthcare costs (incremental cost of $612,700), resulting in an ICER of $2,350,041/QALY.	ibrutinib	15-24	cAMP responsive element modulator	Homo sapiens	136-140
32518952-8	2020	In a scenario analysis where ibrutinib was used in the second-line in the delayed ibrutinib arm, first-line ibrutinib had an incremental cost of $478,823, an incremental effectiveness of 0.05 QALYs, and an ICER of $9,810,360/QALY when compared to second-line use.	ibrutinib	29-38	cAMP responsive element modulator	Homo sapiens	206-210
32301360-8	2020	Sensitivity analyses were conducted to explore uncertainties.Results: Sequential treatment of allopurinol 300 mg/day-allopurinol 600 mg/day-probenecid ("standard of care") was cost-effective compared to no ULT, with an ICER of SGD1,584/QALY.	Allopurinol	94-105	cAMP responsive element modulator	Homo sapiens	219-223
32301360-9	2020	Allopurinol300-allopurinol600-probenecid-febuxostat sequence compared to allopurinol300-allopurinol600-probenecid had an ICER of SGD11,400/QALY.	allopurinol300	0-14	cAMP responsive element modulator	Homo sapiens	121-125
32301360-9	2020	Allopurinol300-allopurinol600-probenecid-febuxostat sequence compared to allopurinol300-allopurinol600-probenecid had an ICER of SGD11,400/QALY.	Probenecid	30-40	cAMP responsive element modulator	Homo sapiens	121-125
32664613-8	2020	In obese women, prevention using Levonorgestrel as of age 30 for five years had an ICER of 72,000 EUR/LYG; the ICER for using oral contraceptives for five years as of age 50 was 450,000 EUR/LYG.	Levonorgestrel	33-47	cAMP responsive element modulator	Homo sapiens	83-87
32498573-9	2021	The ICER of osimertinib exceeds the threshold when compared with afatinib.	osimertinib	12-23	cAMP responsive element modulator	Homo sapiens	4-8
32534736-1	2020	ICER corresponds to a group of alternatively spliced Inducible cAMP Early Repressors with high similarity, but multiple roles, including in circadian rhythm, and are involved in attenuation of cAMP-dependent gene expression.	Cyclic AMP	63-67	cAMP responsive element modulator	Homo sapiens	0-4
32534736-1	2020	ICER corresponds to a group of alternatively spliced Inducible cAMP Early Repressors with high similarity, but multiple roles, including in circadian rhythm, and are involved in attenuation of cAMP-dependent gene expression.	Cyclic AMP	193-197	cAMP responsive element modulator	Homo sapiens	0-4
32534736-6	2020	Icer mRNA has a delayed early response to forskolin.	Colforsin	42-51	cAMP responsive element modulator	Homo sapiens	0-4
32534736-10	2020	In conclusion, we show that ICER and ICERgamma have distinct biochemical properties in tissue expression, DNA binding, and response to forskolin.	Colforsin	135-144	cAMP responsive element modulator	Homo sapiens	28-32
32532543-12	2020	All the aforementioned ICER values were lower than the 2017 Korean GDP per capita of US$29,742.839.	Guanosine Diphosphate	67-70	cAMP responsive element modulator	Homo sapiens	23-27
32037675-7	2020	For dapagliflozin 10 mg, incremental life years, QALYs and costs were 0.24, 0.49 and $2,964, respectively; corresponding to an ICER of $6,103 versus standard of care.	dapagliflozin	4-17	cAMP responsive element modulator	Homo sapiens	127-131
31400755-7	2020	DAA at 20% coverage had an ICER of $27,251/QALY.	daa	0-3	cAMP responsive element modulator	Homo sapiens	27-31
32673457-5	2020	For family members in second and third degrees, the ICER was USD$ 19,380.94 and USD$ 55,913.53, respectively, evidenced when applying the GDP per capita.	Guanosine Diphosphate	138-141	cAMP responsive element modulator	Homo sapiens	52-56
31733533-8	2020	Identification of an allelic variant of the cyclic adenosine monophosphate responsive element modulator gene (CREM), linking impulsivity and multiple substance abuse, opens up prospects of mass screening to advice on harm reduction.	Cyclic AMP	44-74	cAMP responsive element modulator	Homo sapiens	110-114
31634796-9	2020	RESULTS: Under the base-case analysis, pemetrexed plus cisplatin had the greatest total cost among 3 regimens, yielding an ICER of 64 369.97 USD/QALY (2 064 989 THB/QALY) compared with gemcitabine plus cisplatin, and ICER of 8649.16 USD/QALY (277 465 THB/QALY) compared with carboplatin plus paclitaxel.	Cisplatin	55-64	cAMP responsive element modulator	Homo sapiens	123-127
31634796-9	2020	RESULTS: Under the base-case analysis, pemetrexed plus cisplatin had the greatest total cost among 3 regimens, yielding an ICER of 64 369.97 USD/QALY (2 064 989 THB/QALY) compared with gemcitabine plus cisplatin, and ICER of 8649.16 USD/QALY (277 465 THB/QALY) compared with carboplatin plus paclitaxel.	Cisplatin	55-64	cAMP responsive element modulator	Homo sapiens	217-221
31650440-10	2020	Using clinical trial data, Dabigatran150 mg (resp. Dabigatran110 mg) as a first-line treatment vs VKAs yielded an ICER of $ 8077/QALY (resp. $ 13,116/QALY).	dabigatran	27-37	cAMP responsive element modulator	Homo sapiens	114-118
31650440-10	2020	Using clinical trial data, Dabigatran150 mg (resp. Dabigatran110 mg) as a first-line treatment vs VKAs yielded an ICER of $ 8077/QALY (resp. $ 13,116/QALY).	dabigatran	51-61	cAMP responsive element modulator	Homo sapiens	114-118
32148492-14	2020	The only cost-effective strategy was paclitaxel monotherapy for all patients, with an ICER of $53,705/QALY.	Paclitaxel	37-47	cAMP responsive element modulator	Homo sapiens	86-90
32293194-7	2020	A scenario analysis with updated olanzapine unit cost suggested an ICER of 7,857 USD/QALY.Conclusions: Amisulpride is likely to be a cost-effective option with increased effectiveness compared with olanzapine in the treatment of schizophrenia patients in China.	Amisulpride	103-114	cAMP responsive element modulator	Homo sapiens	67-71
31999196-5	2020	One-way sensitivity analysis and probabilistic sensitivity analysis (PSA) were conducted to test the robustness of the model on all parameters.Results: In patients with pre-existing atherosclerosis, two years of treatment with clopidogrel and aspirin would yield total QALYs of 8.776 and 8.576 at associated costs of $18,777 ($2,838) and $12,302 ($1,859), respectively, resulting in an ICER of $32,382 ($4,893) per QALY gained.	clopidogrel	227-238	cAMP responsive element modulator	Homo sapiens	386-390
32179138-8	2020	The ICER in Mexico was US$29 618 (CI: 13 869-66 898) per DALY averted, or 3.0 times per capita GDP.	Guanosine Diphosphate	95-98	cAMP responsive element modulator	Homo sapiens	4-8
32179138-9	2020	For Nicaragua, the ICER was US$29 196 (CI: 14294-72181) per DALY averted, or 16.9 times per capita GDP.	Guanosine Diphosphate	99-102	cAMP responsive element modulator	Homo sapiens	19-23
34007618-0	2020	More Unnecessary Imaginary Worlds - Part 4: The ICER Evidence Report for Crizanlizumab, Voxelotor and L-Glutamine for Sickle Cell Disease.	Glutamine	102-113	cAMP responsive element modulator	Homo sapiens	48-52
31001619-8	2020	RESULTS: Use of fidaxomicin for non-severe initial CDI, vancomycin for severe CDI, fidaxomicin for first recurrence, and FMT for subsequent recurrence (Strategy 44) cost an additional $478 for 0.009 QALYS gained per CDI patient, resulting in an ICER of $31,751 per QALY, below the willingness-to-pay threshold of $100,000/QALY.	Fidaxomicin	16-27	cAMP responsive element modulator	Homo sapiens	245-249
31849282-5	2020	Results: Base-case analysis showed "universal ticagrelor use" was cost-effective for an ICER of 33,875 yuan per QALY gained compared with "universal clopidogrel use" of which gained a 1.6932 QALYs at lowest life-long cost of 2450 yuan.	ticagrelor	46-56	cAMP responsive element modulator	Homo sapiens	88-92
32012839-5	2020	Compared with "Treat at F3"; "Treat at F0" exhibited an ICER of US$3780.20/QALY and US$15,145.98/QALY under the DCV+ASV regimen and PegIFN-based regimen; respectively.	daclatasvir	112-115	cAMP responsive element modulator	Homo sapiens	56-60
33262564-0	2020	ICER"s second update to pricing models of remdesivir for COVID-19.	remdesivir	42-52	cAMP responsive element modulator	Homo sapiens	0-4
31322067-10	2019	Transdermal buprenorphine showed an ICER of about US$11,000.00 while pregabalin showed ICER of roughly US$19,200 this is not rough at all and not ICERs but ICER.	Buprenorphine	12-25	cAMP responsive element modulator	Homo sapiens	36-40
31770689-7	2020	RESULTS: Using USD5104 as the threshold of willingness-to-pay per QALY, patient"s self-management of warfarin was cost-effective when compared to usual warfarin care, with an ICER of USD1395/QALY from societal perspective.	Warfarin	101-109	cAMP responsive element modulator	Homo sapiens	175-179
30889012-6	2019	RESULTS: A small increase in the percentage testing every 6 months among all MSM resulted in 490 averted HIV infections and an average ICER of &OV0556;27 900/QALY gained.	Adenosine Monophosphate	144-147	cAMP responsive element modulator	Homo sapiens	135-139
31344552-5	2019	Here we show that the two transcriptional programs that include, respectively, the "activation gene", interleukin 2 (IL2) and "anergy-related genes", EGR2, EGR3, and CREM have different requirements for transmembrane calcium flux.	Calcium	217-224	cAMP responsive element modulator	Homo sapiens	166-170
31344552-7	2019	These "conditions of limited calcium influx" (CLCI) blocked CD3xCD28-induced IL2 expression but only moderately affected induction of the anergy-related genes EGR2, EGR3, and CREM.	clci	46-50	cAMP responsive element modulator	Homo sapiens	175-179
30973181-11	2019	The probability of mirtazapine being cost-effective ranged from 0.75 to 0.99 when the ICER threshold was JPY 5 000 000.	Mirtazapine	19-30	cAMP responsive element modulator	Homo sapiens	86-90
30973181-13	2019	The probability of mirtazapine being cost-effective ranged from 0.55 to 0.83 when the ICER threshold was JPY 5 000 000.	Mirtazapine	19-30	cAMP responsive element modulator	Homo sapiens	86-90
31139520-6	2019	Gene fusions of Ewing sarcoma breakpoint region 1 (EWSR1) with members of the cAMP response element-binding protein family (CREB) of transcription factors (CREB1, activating transcription factor 1 (ATF1), and cAMP response element modulator (CREM)) have been described in histopathologically diverse mesenchymal neoplasms such as AFH, hyalinising clear cell carcinomas of salivary glands, primary pulmonary myxoid sarcoma, and clear cell sarcoma.	Cyclic AMP	78-82	cAMP responsive element modulator	Homo sapiens	242-246
32382247-0	2020	ICER releases evidence report on elexacaftor/tezacaftor/ivacaftor for cystic fibrosis.	elexacaftor	33-44	cAMP responsive element modulator	Homo sapiens	0-4
32382247-0	2020	ICER releases evidence report on elexacaftor/tezacaftor/ivacaftor for cystic fibrosis.	tezacaftor	45-55	cAMP responsive element modulator	Homo sapiens	0-4
32382247-0	2020	ICER releases evidence report on elexacaftor/tezacaftor/ivacaftor for cystic fibrosis.	ivacaftor	56-65	cAMP responsive element modulator	Homo sapiens	0-4
31824183-10	2019	Ivabradine plus standard treatment costs more than standard treatment (71,071 vs 18,736 THB or 2,161.54 vs 569.82 USD), and is more effective (6.08 QALYs vs 5.84 QALYs), yielding an ICER of 214,219 THB/QALY (6,515.16 USD/QALY).	Ivabradine	0-10	cAMP responsive element modulator	Homo sapiens	182-186
31576163-11	2019	Results: From the payer"s perspective, pregabalin-containing treatments were more costly (JPY 61,779 versus JPY 26,428) but also more effective (0.763 QALYs versus 0.727 QALYs) than the usual care, with an ICER of JPY 970,314 per QALY gained.	pregabalin	39-49	cAMP responsive element modulator	Homo sapiens	206-210
30873251-23	2019	For adults with mild to moderate major depression, guided iCBT was associated with increases in both quality-adjusted survival (0.04 quality-adjusted life-years [QALYs]) and cost ($1,257), yielding an ICER of $31,575 per QALY gained when compared with usual care.	icbt	58-62	cAMP responsive element modulator	Homo sapiens	201-205
30873251-24	2019	In adults with anxiety disorders, guided iCBT was also associated with increases in both quality-adjusted survival (0.03 QALYs) and cost ($1,395), yielding an ICER of $43,214 per QALY gained when compared with unguided iCBT.	icbt	41-45	cAMP responsive element modulator	Homo sapiens	159-163
30873251-25	2019	In this population, guided iCBT was associated with an ICER of $26,719 per QALY gained when compared with usual care.	icbt	27-31	cAMP responsive element modulator	Homo sapiens	55-59
30821231-19	2019	Within the restricted EU-label population (symptomatic and progressive MTC with CEA/CTN doubling times of <= 24 months), the ICER for vandetanib is expected to be > $66,000 per QALY gained.	vandetanib	137-147	cAMP responsive element modulator	Homo sapiens	128-132
30821231-28	2019	Within the restricted EU-label population, the ICER for vandetanib is expected to be > $66,000 per QALY gained.	vandetanib	56-66	cAMP responsive element modulator	Homo sapiens	47-51
30196273-9	2019	GSS testing in both symptomatic and asymptomatic MSM compared with GSS in symptomatic MSM only resulted in one prevented epididymitis case (95% UI: 0-2), 1.1 QALY gained (95% UI: 0.1-3.3), $148 000 additional costs (95% UI: $86 000 to-$217 000) and an ICER of $177 000 (95% UI: $67 000-to $705 000) per QALY gained over 10 years.	gss	0-3	cAMP responsive element modulator	Homo sapiens	252-256
30729168-9	2019	Compared to no therapy, alendronate was either dominant or was associated with a low incremental cost per QALY (quality-adjusted life years) gained (ICER)-less than CAN$3,751 based on age and fracture history.	Alendronate	24-35	cAMP responsive element modulator	Homo sapiens	149-153
30729168-10	2019	In comparison with alendronate, both zoledronate and denosumab were either dominated or associated with a high ICER-greater than CAN$660,000 per QALY.	Zoledronic Acid	37-48	cAMP responsive element modulator	Homo sapiens	111-115
30729168-11	2019	For women unable to tolerate bisphosphonates, dependent on age and fracture history, the ICER for zoledronate versus no therapy ranged from CAN$17,770 to CAN$94,365 per QALY.	Zoledronic Acid	98-109	cAMP responsive element modulator	Homo sapiens	89-93
30791790-4	2018	For genotype 1, the highest number of ICER comparison corresponds to sofosbuvir (SOF) triple therapy and SOF-based combinations which reported a cost per QALY systematically ranging from negative to lower than US$100,000 when compared with no treatment or dual therapy or Simeprevir triple therapy.	Sofosbuvir	69-79	cAMP responsive element modulator	Homo sapiens	38-42
30791790-4	2018	For genotype 1, the highest number of ICER comparison corresponds to sofosbuvir (SOF) triple therapy and SOF-based combinations which reported a cost per QALY systematically ranging from negative to lower than US$100,000 when compared with no treatment or dual therapy or Simeprevir triple therapy.	Sofosbuvir	81-84	cAMP responsive element modulator	Homo sapiens	38-42
30791790-4	2018	For genotype 1, the highest number of ICER comparison corresponds to sofosbuvir (SOF) triple therapy and SOF-based combinations which reported a cost per QALY systematically ranging from negative to lower than US$100,000 when compared with no treatment or dual therapy or Simeprevir triple therapy.	Simeprevir	272-282	cAMP responsive element modulator	Homo sapiens	38-42
31158087-8	2018	RESULTS AND LIMITATIONS: The model predicted that docetaxel would extend survival (discounted quality-adjusted survival) by 0.89 yr (0.51) for metastatic PC and 0.78 yr (0.39) for nonmetastatic PC, and would be cost-effective in metastatic PC (ICER $5514/QALY vs SOC) and nonmetastatic PC (higher QALYs, lower costs vs SOC).	Docetaxel	50-59	cAMP responsive element modulator	Homo sapiens	244-248
29691782-10	2018	Adherence to aspirin had an ICER of US$25/QALY in the non-diabetic population, while it saved US$297 per patient over a 5-year period in the type II diabetes population.	Aspirin	13-20	cAMP responsive element modulator	Homo sapiens	28-32
30150402-2	2018	The transcriptional factor, inducible cAMP early repressor/cAMP response element modulator (ICER/CREM), has been shown to be induced in Th17 cells and to be overexpressed in CD4+ T cells from the patients with systemic lupus erythematosus (SLE).	Cyclic AMP	38-42	cAMP responsive element modulator	Homo sapiens	59-90
30498400-11	2018	In order for the ICER for the combined intervention to be within a range of 1 GDP per capita per DALY averted, the annual malaria incidence in the area should be at least 13%, and the protective-effectiveness of combined implementation should be at least 53%.	Guanosine Diphosphate	78-81	cAMP responsive element modulator	Homo sapiens	17-21
29600384-14	2018	The company"s base-case ICER was $46,932 per quality-adjusted life-year (QALY) gained for the comparison of Nab-Pac + Gem versus Gem.	nab-pac	108-115	cAMP responsive element modulator	Homo sapiens	24-28
29600384-14	2018	The company"s base-case ICER was $46,932 per quality-adjusted life-year (QALY) gained for the comparison of Nab-Pac + Gem versus Gem.	4-(N)-lauroylgemcitabine	118-121	cAMP responsive element modulator	Homo sapiens	24-28
29600384-16	2018	The AC concluded that the most plausible ICER for treatment with Nab-Pac + Gem versus Gem was in the range of $41,000-$46,000 per QALY gained.	nab-pac	65-72	cAMP responsive element modulator	Homo sapiens	41-45
30150402-2	2018	The transcriptional factor, inducible cAMP early repressor/cAMP response element modulator (ICER/CREM), has been shown to be induced in Th17 cells and to be overexpressed in CD4+ T cells from the patients with systemic lupus erythematosus (SLE).	Cyclic AMP	38-42	cAMP responsive element modulator	Homo sapiens	92-96
30150402-2	2018	The transcriptional factor, inducible cAMP early repressor/cAMP response element modulator (ICER/CREM), has been shown to be induced in Th17 cells and to be overexpressed in CD4+ T cells from the patients with systemic lupus erythematosus (SLE).	Cyclic AMP	38-42	cAMP responsive element modulator	Homo sapiens	97-101
29958739-10	2018	One-way sensitivity analyses found vaccine cost to be the common and most influential parameter for ICER of each vaccination strategy to become <1 x GDP per capita.	Guanosine Diphosphate	152-155	cAMP responsive element modulator	Homo sapiens	100-104
30209002-19	2018	For GI and lung NETs, we estimated an ICER for everolimus compared with BSC of $44,557 per QALY.	Everolimus	47-57	cAMP responsive element modulator	Homo sapiens	38-42
30233223-15	2018	Overall, based on local ICER thresholds (MXN 184,665; US $10,326), voriconazole was considered a cost-effective option for prophylaxis of IFI in Mexico.	Voriconazole	67-79	cAMP responsive element modulator	Homo sapiens	24-28
30026696-3	2018	Hemizygous mice with a cardiomyocyte-specific overexpression of the human cAMP response element modulator (CREM) isoform IbDeltaC-X spontaneously develop AF on grounds of an arrhythmogenic substrate consisting of alterations in structure, conduction, and calcium handling.	Calcium	255-262	cAMP responsive element modulator	Homo sapiens	74-105
29771512-3	2018	Here, we show that the ATP-dependent enzyme CreM installs the diazo group in cremeomycin via late-stage N-N bond formation using nitrite.	Adenosine Triphosphate	23-26	cAMP responsive element modulator	Homo sapiens	44-48
29771512-3	2018	Here, we show that the ATP-dependent enzyme CreM installs the diazo group in cremeomycin via late-stage N-N bond formation using nitrite.	diazo	62-67	cAMP responsive element modulator	Homo sapiens	44-48
29771512-3	2018	Here, we show that the ATP-dependent enzyme CreM installs the diazo group in cremeomycin via late-stage N-N bond formation using nitrite.	cremeomycin	77-88	cAMP responsive element modulator	Homo sapiens	44-48
29771512-3	2018	Here, we show that the ATP-dependent enzyme CreM installs the diazo group in cremeomycin via late-stage N-N bond formation using nitrite.	Nitrites	129-136	cAMP responsive element modulator	Homo sapiens	44-48
30026696-3	2018	Hemizygous mice with a cardiomyocyte-specific overexpression of the human cAMP response element modulator (CREM) isoform IbDeltaC-X spontaneously develop AF on grounds of an arrhythmogenic substrate consisting of alterations in structure, conduction, and calcium handling.	Calcium	255-262	cAMP responsive element modulator	Homo sapiens	107-111
28716519-8	2018	In the lifetime horizon model, The ICER was $45,046 per QALY for combination treatment compared with simvastatin alone.	Simvastatin	101-112	cAMP responsive element modulator	Homo sapiens	35-39
29925386-2	2018	The cAMP response element (CREM)alpha is known to play a major role in regulation of T cells in SLE, colitis, and EAE.	Cyclic AMP	4-8	cAMP responsive element modulator	Homo sapiens	27-31
29848775-14	2018	BC-GN with an ASP (ICER, -$23,587/quality-adjusted life year), PCR with an ASP (ICER, -$19,833/quality-adjusted life year), and PCR without an ASP (ICER, -$21,039/quality-adjusted life year) were other cost-effective options.	bc-gn	0-5	cAMP responsive element modulator	Homo sapiens	19-23
29603882-8	2018	RESULTS: Compared to SOC, DTG improved 5-year survival from 76.7% to 83.0%, increased life expectancy from 22.0 to 24.8 years (14.0 to 15.5 years, discounted), averted 13,000 transmitted HIV infections over 5 years, increased discounted lifetime care costs from $3040 to $3240, and resulted in a lifetime ICER of $130/YLS, less than 10% of India"s per capita GDP in 2015.	dolutegravir	26-29	cAMP responsive element modulator	Homo sapiens	305-309
29587666-10	2018	RESULTS: In the base-case analysis, the ICER for afatinib versus pemetrexed-cisplatin was SG$137,648 per quality-adjusted life year (QALY) gained and SG$109,172 per life-year gained.	Afatinib	49-57	cAMP responsive element modulator	Homo sapiens	40-44
29587666-10	2018	RESULTS: In the base-case analysis, the ICER for afatinib versus pemetrexed-cisplatin was SG$137,648 per quality-adjusted life year (QALY) gained and SG$109,172 per life-year gained.	Pemetrexed	65-75	cAMP responsive element modulator	Homo sapiens	40-44
29587666-10	2018	RESULTS: In the base-case analysis, the ICER for afatinib versus pemetrexed-cisplatin was SG$137,648 per quality-adjusted life year (QALY) gained and SG$109,172 per life-year gained.	Cisplatin	76-85	cAMP responsive element modulator	Homo sapiens	40-44
29587666-11	2018	One-way sensitivity analysis showed the ICER was most sensitive to variations in the utility values, the cost of afatinib and time horizon.	Afatinib	113-121	cAMP responsive element modulator	Homo sapiens	40-44
29587666-12	2018	Scenario analyses showed that even reducing the cost of afatinib by 50% led to a high ICER which was unlikely to represent a cost-effective use of healthcare resources.	Afatinib	56-64	cAMP responsive element modulator	Homo sapiens	86-90
29329779-4	2018	This analysis indicated increased expression of target genes of cAMP responsive element modulator (CREM) after 24 h treatment with the alpha1-AR agonist phenylephrine, but not the ETR agonist endothelin-1, suggesting a specific role for the alpha1-AR in promoting cAMP production in cardiomyocytes.	Phenylephrine	153-166	cAMP responsive element modulator	Homo sapiens	64-97
29329779-4	2018	This analysis indicated increased expression of target genes of cAMP responsive element modulator (CREM) after 24 h treatment with the alpha1-AR agonist phenylephrine, but not the ETR agonist endothelin-1, suggesting a specific role for the alpha1-AR in promoting cAMP production in cardiomyocytes.	Phenylephrine	153-166	cAMP responsive element modulator	Homo sapiens	99-103
29329779-4	2018	This analysis indicated increased expression of target genes of cAMP responsive element modulator (CREM) after 24 h treatment with the alpha1-AR agonist phenylephrine, but not the ETR agonist endothelin-1, suggesting a specific role for the alpha1-AR in promoting cAMP production in cardiomyocytes.	Cyclic AMP	64-68	cAMP responsive element modulator	Homo sapiens	99-103
29603882-9	2018	DTG maintained an ICER below 50% of India"s per capita GDP as long as the annual three-drug regimen cost was <=$180/year.	dolutegravir	0-3	cAMP responsive element modulator	Homo sapiens	18-22
27752788-8	2017	Sitagliptin, saxagliptin and vildagliptin had an ICER below 25,000 $/QALY, as second-line and as add-ons to metformin, in comparison to sulfonylureas.	Sitagliptin Phosphate	0-11	cAMP responsive element modulator	Homo sapiens	49-53
28741965-8	2018	The cost per QALY gained (ICER) for DTG compared to EFV was $6,939.	dolutegravir	36-39	cAMP responsive element modulator	Homo sapiens	26-30
28117433-7	2018	Genotype-guided treatment was cost-effective compared with universal clopidogrel use (ICER of USD2560/QALY).	Clopidogrel	69-80	cAMP responsive element modulator	Homo sapiens	86-90
27145493-7	2017	Additionally, for patients with high-volume disease, the increased cost and effectiveness were $14 627.75 and 0.69 QALYs in docetaxel + ADT group versus the ADT alone group, and the ICER was $21 199.63 per QALY.	adt	136-139	cAMP responsive element modulator	Homo sapiens	182-186
27752788-8	2017	Sitagliptin, saxagliptin and vildagliptin had an ICER below 25,000 $/QALY, as second-line and as add-ons to metformin, in comparison to sulfonylureas.	saxagliptin	13-24	cAMP responsive element modulator	Homo sapiens	49-53
27752788-8	2017	Sitagliptin, saxagliptin and vildagliptin had an ICER below 25,000 $/QALY, as second-line and as add-ons to metformin, in comparison to sulfonylureas.	Vildagliptin	29-41	cAMP responsive element modulator	Homo sapiens	49-53
28650086-17	2017	The ICER of CDT compared to anticoagulation was $317,042 per QALY gained.	cdt	12-15	cAMP responsive element modulator	Homo sapiens	4-8
28316007-13	2017	For the comparison of treatment with T-VEC versus ipilimumab, the ICER per QALY gained was -$16,367 using the modified Korn method and -$60,271 using the two-step Korn method.	t-vec	37-42	cAMP responsive element modulator	Homo sapiens	66-70
28751244-8	2017	RESULTS: For all EGFR mutation-positive NSCLCs, the afatinib-versus-gefitinib ICER of was $45,211 per quality-adjusted life-year (QALY) (0.170 QALY gain for an incremental cost of $7697).	Afatinib	52-60	cAMP responsive element modulator	Homo sapiens	78-82
28751244-8	2017	RESULTS: For all EGFR mutation-positive NSCLCs, the afatinib-versus-gefitinib ICER of was $45,211 per quality-adjusted life-year (QALY) (0.170 QALY gain for an incremental cost of $7697).	Gefitinib	68-77	cAMP responsive element modulator	Homo sapiens	78-82
28229209-8	2017	The ICER of a second DVIU prior to urethroplasty was $86,280 per unobstructed voider, while the ICER of a third DVIU was $172,205.	dviu	21-25	cAMP responsive element modulator	Homo sapiens	4-8
28914229-19	2017	In the base case using a modified RSS the mean incremental cost was $31,900 for pooled DMTs compared with BSC and the mean incremental quality-adjusted life-years (QALYs) were 0.943, giving an ICER of $33,800 per QALY gained for people with RRMS.	RSS	34-37	cAMP responsive element modulator	Homo sapiens	193-197
28784605-1	2017	BACKGROUND: Reduced expression of genes regulated by the transcription factors CREB/CREM (cAMP response element-binding protein/modulator) is linked to atrial fibrillation (AF) susceptibility in patients.	Cyclic AMP	90-94	cAMP responsive element modulator	Homo sapiens	84-88
27943135-8	2017	Based on the ERG"s preferred base case, the deterministic incremental cost-effectiveness analysis (ICER) for degarelix versus 3-monthly triptorelin was $14,798 per quality-adjusted life-year (QALY) gained.	acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide	109-118	cAMP responsive element modulator	Homo sapiens	99-103
28620949-5	2017	RESULTS: The most cost-effective rescue medication was buccal midazolam (incremental cost-effectiveness ratio ([ICER]: $13.16/SS) followed by nasal midazolam (ICER: $38.19/SS).	Midazolam	62-71	cAMP responsive element modulator	Homo sapiens	112-116
28554192-13	2017	The lifetime analysis suggested that first-line etanercept-methotrexate would result in 0.15 additional lifetime QALY, but this gain would cost an incremental $77 290, leading to an ICER of $521 520 per QALY per patient.	etanercept-methotrexate	48-71	cAMP responsive element modulator	Homo sapiens	182-186
28577884-10	2017	In the laparoscopic permanent contraception cohort, OS is cost-effective with an ICER of $31,432/QALY compared to tubal ligation, and remains cost-effective as long as it reduces ovarian cancer risk by 54%.	Osmium	52-54	cAMP responsive element modulator	Homo sapiens	81-85
28332433-11	2017	The ICER ranged from $10,600-$65,000 per QALY in scenario analyses, including a sub-group analysis limited to patients with prior chemotherapy and crizotinib treatment.	Crizotinib	147-157	cAMP responsive element modulator	Homo sapiens	4-8
27111538-9	2017	Tramadol"s ICER was highly sensitive to its effect on TKA outcomes.	Tramadol	0-8	cAMP responsive element modulator	Homo sapiens	11-15
28680172-8	2017	RESULTS: For treatment lasting 3 months, apixaban represented the most cost-effective DOAC relative to low-molecular-weight heparin (LMWH) + vitamin K antagonist, with an ICER of $7379.66.	apixaban	41-49	cAMP responsive element modulator	Homo sapiens	171-175
28680172-9	2017	For 6 months of treatment, apixaban again represented the most cost-effective treatment, with an ICER of $84.08 per QALY gained, and this drug dominated all the other strategies at 12 months.	apixaban	27-35	cAMP responsive element modulator	Homo sapiens	97-101
27919186-8	2017	RESULTS: NAB-P + GEM was associated with differentials of +0.180 LY and +0.127 QALY gained over GEM at an incremental total cost of $25,965; yielding an ICER of $144,096/LY and ICUR of $204,369/QALY gained.	nab-p	9-14	cAMP responsive element modulator	Homo sapiens	153-157
27919186-9	2017	FOLFIRINOX was associated with differentials of +0.368 LY and +0.249 QALY gained over GEM at an incremental total cost of $93,045; yielding an ICER of $253,162/LY and ICUR of $372,813/QALY gained.	folfirinox	0-10	cAMP responsive element modulator	Homo sapiens	143-147
27919186-11	2017	FOLFIRINOX had an ICER of $358,067/LY and an ICUR of $547,480/QALY gained over NAB-P + GEM.	folfirinox	0-10	cAMP responsive element modulator	Homo sapiens	18-22
28000167-7	2017	RESULTS: Thromboprophylaxis with apixaban was estimated to have a higher cost (US $178.70) and more health benefits (0.0025 QALY) than thromboprophylaxis with enoxaparin over a 5-year time horizon, which resulted in an ICER of US $71,244 per QALY gained and was more than three times the GDP per capita of China in 2014 (US $22,140).	apixaban	33-41	cAMP responsive element modulator	Homo sapiens	219-223
26750641-4	2016	RESULTS: At 30 years, total incremental cost for THC/CBD plus SoC treatment was estimated at $3,836/patient (ICER: $10,891/quality-adjusted life year [QALY]).	Dronabinol	49-52	cAMP responsive element modulator	Homo sapiens	109-113
27822872-0	2017	Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells.	Cyclic AMP	37-67	cAMP responsive element modulator	Homo sapiens	85-89
27822872-3	2017	ICER negatively transcriptional regulators of cAMP activators such as CREM and CREB.	Cyclic AMP	46-50	cAMP responsive element modulator	Homo sapiens	0-4
27822872-3	2017	ICER negatively transcriptional regulators of cAMP activators such as CREM and CREB.	Cyclic AMP	46-50	cAMP responsive element modulator	Homo sapiens	70-74
27822872-9	2017	ICER seems to be responsible for decrease in G1 transition, based on reduced Cdk4 protein, decreased proliferation and functional studies with propidium iodide.	Propidium	143-159	cAMP responsive element modulator	Homo sapiens	0-4
27484440-11	2017	ICER ratio was calculated and found that a cost of INR 61.47 per extra QoL gained by Duloxetine.	Duloxetine Hydrochloride	85-95	cAMP responsive element modulator	Homo sapiens	0-4
27574722-9	2017	The disease stage-stratified ICER analysis found that the pemetrexed/platinum incurred total Medicare costs of $536,424 and $283,560 per observed additional year of life relative to platinum monotherapy and paclitaxel/carboplatin, respectively.	Pemetrexed	58-68	cAMP responsive element modulator	Homo sapiens	29-33
27574722-9	2017	The disease stage-stratified ICER analysis found that the pemetrexed/platinum incurred total Medicare costs of $536,424 and $283,560 per observed additional year of life relative to platinum monotherapy and paclitaxel/carboplatin, respectively.	Platinum	69-77	cAMP responsive element modulator	Homo sapiens	29-33
27770556-12	2017	Although sorafenib use was associated with a survival benefit (HR, 0.61; 95% CI, 0.47-0.79) among patients with decompensated cirrhosis, the median survival benefit was 31 days, and it was not cost-effective (ICER, $224,914 per life year gained).	Sorafenib	9-18	cAMP responsive element modulator	Homo sapiens	209-213
27581246-8	2016	RESULTS: Thromboprophylaxis with apixaban was estimated to have a higher cost (US$68) and more health benefits (0.0006 QALYs) than thromboprophylaxis with enoxaparin over a 5.5-year time horizon, resulting in an ICER of US$108,497 per QALY gained.	apixaban	33-41	cAMP responsive element modulator	Homo sapiens	212-216
26750641-4	2016	RESULTS: At 30 years, total incremental cost for THC/CBD plus SoC treatment was estimated at $3,836/patient (ICER: $10,891/quality-adjusted life year [QALY]).	Cannabidiol	53-56	cAMP responsive element modulator	Homo sapiens	109-113
27282692-5	2016	The ICER of glatiramer acetate with EQ-5D was US$182,291 for The Netherlands and US$153,476 for the UK.	Glatiramer Acetate	12-30	cAMP responsive element modulator	Homo sapiens	4-8
27900262-8	2016	The decrease of both Hdac5 and Hdac6 by hypoxia was associated with altered expression of adipokines and of the inducible cAMP early repressor (Icer), a key repressor that is defective in human and mice obesity.	Cyclic AMP	122-126	cAMP responsive element modulator	Homo sapiens	144-148
27711200-11	2016	In the declining epidemic, dual DAA yielded an ICER of 344 $/QALY while in the stable epidemic dual DAA led to cost-savings.	daa	32-35	cAMP responsive element modulator	Homo sapiens	47-51
27402969-8	2016	RESULTS: Amoxicillin was associated with an ICER of $8216 ($6540) per QALY gained when the cost of resistance was excluded.	Amoxicillin	9-20	cAMP responsive element modulator	Homo sapiens	44-48
27581874-7	2016	RESULTS: LAAO was considered cost-effective compared with aspirin, clopidogrel plus aspirin, and warfarin, with ICER of US$5,115, $2,447, and $6,298 per QALY gained, respectively.	laao	9-13	cAMP responsive element modulator	Homo sapiens	112-116
27552849-11	2016	Given the low ICER per life year gained, DMP COPD may constitute a cost-effective option to promote COPD population health.	dmp	41-44	cAMP responsive element modulator	Homo sapiens	14-18
26899345-3	2016	We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A.	Cyclic AMP	124-128	cAMP responsive element modulator	Homo sapiens	210-214
27273166-5	2016	The target enzyme was immobilised on the silica capillary via Schiff base formation (to give LmNDKb-ICER-Schiff) or affinity attachment (to give LmNDKb-ICER-His).	Silicon Dioxide	41-47	cAMP responsive element modulator	Homo sapiens	152-156
27273166-5	2016	The target enzyme was immobilised on the silica capillary via Schiff base formation (to give LmNDKb-ICER-Schiff) or affinity attachment (to give LmNDKb-ICER-His).	Histidine	157-160	cAMP responsive element modulator	Homo sapiens	152-156
27276081-8	2016	RESULTS: Sofosbuvir/ledipasvir was cost-effective in treatment-experienced patients with an ICER of US$21,612.	Sofosbuvir	9-19	cAMP responsive element modulator	Homo sapiens	92-96
27276081-8	2016	RESULTS: Sofosbuvir/ledipasvir was cost-effective in treatment-experienced patients with an ICER of US$21,612.	ledipasvir	20-30	cAMP responsive element modulator	Homo sapiens	92-96
26595724-12	2016	In the base-case analysis, among patients receiving 8 or 12 weeks of sofosbuvir-ledipasvir treatment, treating all fibrosis stages compared with treating stages F3 and F4 adds 0.73 QALYs and $28,899, for an ICER of $39,475 per QALY gained.	Sofosbuvir	69-79	cAMP responsive element modulator	Homo sapiens	207-211
26525846-10	2016	Incorporating OTC naproxen rather than ibuprofen added 0.01 QALYs and increased costs by $300, resulting in an ICER of $54,800/QALY.	Naproxen	18-26	cAMP responsive element modulator	Homo sapiens	111-115
26525846-11	2016	Using prescription naproxen with OTC PPIs led to an ICER of $76,700/QALY, while use of prescription naproxen with prescription PPIs resulted in an ICER of $252,300/QALY.	Naproxen	100-108	cAMP responsive element modulator	Homo sapiens	147-151
26727369-11	2016	There is 90% probability for ICER to be cost effective at INR 2300 willingness to pay, which is 5.5% of India"s GDP per capita.	Guanosine Diphosphate	112-115	cAMP responsive element modulator	Homo sapiens	29-33
26613118-8	2016	The average ICER per QALY for dasatinib- vs imatinib-initiating sequences is $100,000 for an imatinib-resistant population.	Dasatinib	30-39	cAMP responsive element modulator	Homo sapiens	12-16
26613118-8	2016	The average ICER per QALY for dasatinib- vs imatinib-initiating sequences is $100,000 for an imatinib-resistant population.	Imatinib Mesylate	44-52	cAMP responsive element modulator	Homo sapiens	12-16
26613118-8	2016	The average ICER per QALY for dasatinib- vs imatinib-initiating sequences is $100,000 for an imatinib-resistant population.	Imatinib Mesylate	93-101	cAMP responsive element modulator	Homo sapiens	12-16
26613118-9	2016	The average ICER per QALY for dasatinib- vs nilotinib-initiating sequences is $170,000 for an imatinib-resistant population, and $160,000 for an imatinib-intolerant population.	Dasatinib	30-39	cAMP responsive element modulator	Homo sapiens	12-16
26613118-9	2016	The average ICER per QALY for dasatinib- vs nilotinib-initiating sequences is $170,000 for an imatinib-resistant population, and $160,000 for an imatinib-intolerant population.	nilotinib	44-53	cAMP responsive element modulator	Homo sapiens	12-16
26613118-9	2016	The average ICER per QALY for dasatinib- vs nilotinib-initiating sequences is $170,000 for an imatinib-resistant population, and $160,000 for an imatinib-intolerant population.	Imatinib Mesylate	94-102	cAMP responsive element modulator	Homo sapiens	12-16
26613118-9	2016	The average ICER per QALY for dasatinib- vs nilotinib-initiating sequences is $170,000 for an imatinib-resistant population, and $160,000 for an imatinib-intolerant population.	Imatinib Mesylate	145-153	cAMP responsive element modulator	Homo sapiens	12-16
26595724-18	2016	A 46% reduction in cost of sofosbuvir-ledipasvir therapy decreases the ICER for treating at all fibrosis stages by 48%.	Sofosbuvir	27-37	cAMP responsive element modulator	Homo sapiens	71-75
26595724-18	2016	A 46% reduction in cost of sofosbuvir-ledipasvir therapy decreases the ICER for treating at all fibrosis stages by 48%.	ledipasvir	38-48	cAMP responsive element modulator	Homo sapiens	71-75
26715178-13	2015	The model showed that: over 180 days, fondaparinux dominates enoxaparin, producing similar estimates of QALYs gained and saving $439; over a patient"s lifetime, fondaparinux yields an ICER of $4293/QALY.	Fondaparinux	161-173	cAMP responsive element modulator	Homo sapiens	184-188
26544203-11	2015	The ICER of DCV/ASV compared to PR was US$ 16,635/QALY at a total treatment price of US$ 77,419; US$11,581 /QALY at a price of US$ 58,065; US$ 6,375/QALY at a price of US$ 38,710; and US$ 1,364 /QALY at a price of US$ 19,355.	daclatasvir	12-15	cAMP responsive element modulator	Homo sapiens	4-8
26684327-12	2015	Ranolazine plus SoC resulted in an ICER equal to $4620 per QALY gained, well below the threshold of $34,000 per QALY gained.	Ranolazine	0-10	cAMP responsive element modulator	Homo sapiens	35-39
26544203-11	2015	The ICER of DCV/ASV compared to PR was US$ 16,635/QALY at a total treatment price of US$ 77,419; US$11,581 /QALY at a price of US$ 58,065; US$ 6,375/QALY at a price of US$ 38,710; and US$ 1,364 /QALY at a price of US$ 19,355.	asunaprevir	16-19	cAMP responsive element modulator	Homo sapiens	4-8
26424421-9	2015	RESULTS: The average ICER of paliperidone compared to placebo reached 28,935 EUR/QALY.	Paliperidone Palmitate	29-41	cAMP responsive element modulator	Homo sapiens	21-25
25847572-11	2015	In genotype 3, sofosbuvir had a weighted ICER of $18 761/QALY.	Sofosbuvir	15-25	cAMP responsive element modulator	Homo sapiens	41-45
26424421-11	2015	CONCLUSIONS: Treatment of SAD with paliperidone results in acceptable ICER and high probability of being cost-effective compared to placebo.	Paliperidone Palmitate	35-47	cAMP responsive element modulator	Homo sapiens	70-74
25906420-14	2015	Applying the latest OS data from BREAK-3 to a less complex model structure increased the estimated ICER for dabrafenib compared with dacarbazine from $60,980 to $112,727 per QALY gained.	dabrafenib	108-118	cAMP responsive element modulator	Homo sapiens	99-103
25958192-10	2015	The ICER comparing olanzapine to risperidone was US$5868 per DALY averted.	Olanzapine	19-29	cAMP responsive element modulator	Homo sapiens	4-8
25958192-10	2015	The ICER comparing olanzapine to risperidone was US$5868 per DALY averted.	Risperidone	33-44	cAMP responsive element modulator	Homo sapiens	4-8
26303225-12	2015	The ICER for olaparib maintenance therapy in patients with a BRCA mutation was $258,864 per PF-LYS.	olaparib	13-21	cAMP responsive element modulator	Homo sapiens	4-8
26303225-13	2015	If the cost of olaparib was decreased to $2500 per month, the ICER was $49,584.	olaparib	15-23	cAMP responsive element modulator	Homo sapiens	62-66
26303225-14	2015	For the 4439 patients with wild-type BRCA, the cost of maintenance therapy was $444.2M; the ICER was $600,552 per PF-LYS.	Lysine	117-120	cAMP responsive element modulator	Homo sapiens	92-96
26303225-16	2015	To achieve an ICER of less than $50,000, the cost of olaparib should be $2500 or less per month.	olaparib	53-61	cAMP responsive element modulator	Homo sapiens	14-18
25906420-14	2015	Applying the latest OS data from BREAK-3 to a less complex model structure increased the estimated ICER for dabrafenib compared with dacarbazine from $60,980 to $112,727 per QALY gained.	Dacarbazine	133-144	cAMP responsive element modulator	Homo sapiens	99-103
26243076-11	2015	FINDINGS: First-line tofacitinib used before the standard of care (base-case analysis) increased both treatment costs and QALYs gained versus the standard-of-care treatment sequence, resulting in an ICER of KRW 13,228,910 per QALY.	tofacitinib	21-32	cAMP responsive element modulator	Homo sapiens	199-203
24951606-12	2014	Lobectomy was cost effective when compared with SABR, with an ICER of $55,909.06.	sabr	48-52	cAMP responsive element modulator	Homo sapiens	62-66
25764608-11	2015	The incremental cost effectiveness (ICER) ratio was 2,407,180 baht per QALYs, with a very low probability that robotic prostatectomy would be cost effective at the Thai-willingness-to pay (WTP) threshold of 160,000 baht/ QALY.	baht	62-66	cAMP responsive element modulator	Homo sapiens	36-40
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	Tetracycline	127-139	cAMP responsive element modulator	Homo sapiens	71-75
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	Tetracycline	127-130	cAMP responsive element modulator	Homo sapiens	71-75
24859238-4	2014	A unitary tet-on system that combined a tet-on activator cassette was also developed and was controlled by the human insulin promoter with a responder cassette containing genes encoding ICER Igamma regulated by the TRE promoter.	Tetracycline	10-13	cAMP responsive element modulator	Homo sapiens	186-190
24859238-5	2014	To determine whether dox-enhanced ICER Igamma expression affected insulin production, the unitary tet-on ICER Igamma vector was introduced into a mouse pancreatic beta-cell line and then the cells were treated with 0.1-1 mg/ml dox.	Doxycycline	21-24	cAMP responsive element modulator	Homo sapiens	34-38
24859238-5	2014	To determine whether dox-enhanced ICER Igamma expression affected insulin production, the unitary tet-on ICER Igamma vector was introduced into a mouse pancreatic beta-cell line and then the cells were treated with 0.1-1 mg/ml dox.	Tetracycline	98-101	cAMP responsive element modulator	Homo sapiens	105-109
24859238-8	2014	In addition, porcine transgenic fibroblasts containing dox-inducible ICER Igamma were generated.	Doxycycline	55-58	cAMP responsive element modulator	Homo sapiens	69-73
25820703-11	2015	RESULTS OF BASE-CASE ANALYSIS: The ICER of sofosbuvir-based treatment was less than $100,000 per QALY in cirrhotic patients (genotype 2 or 3 and treatment-naive or treatment-experienced) and in treatment-experienced noncirrhotic patients but was greater than $200,000 per QALY in treatment-naive noncirrhotic patients.	Sofosbuvir	43-53	cAMP responsive element modulator	Homo sapiens	35-39
25820703-12	2015	RESULTS OF SENSITIVITY ANALYSIS: The ICER of sofosbuvir-based therapy for treatment-naive noncirrhotic patients with genotype 2 or 3 infection was less than $100,000 per QALY when the cost of sofosbuvir was reduced by approximately 40% and 60%, respectively.	Sofosbuvir	45-55	cAMP responsive element modulator	Homo sapiens	37-41
25820703-12	2015	RESULTS OF SENSITIVITY ANALYSIS: The ICER of sofosbuvir-based therapy for treatment-naive noncirrhotic patients with genotype 2 or 3 infection was less than $100,000 per QALY when the cost of sofosbuvir was reduced by approximately 40% and 60%, respectively.	Sofosbuvir	192-202	cAMP responsive element modulator	Homo sapiens	37-41
25775312-11	2015	RESULTS OF BASE-CASE ANALYSIS: Sofosbuvir-based therapies added 0.56 QALY relative to the oSOC at an ICER of $55 400 per additional QALY.	Sofosbuvir	31-41	cAMP responsive element modulator	Homo sapiens	101-105
25548525-11	2015	In anaplastic lymphoma kinase-positive nonsquamous advanced NSCLC, the ICER of first-line crizotinib compared with that of chemotherapy was $255,970 per QALY.	Crizotinib	90-100	cAMP responsive element modulator	Homo sapiens	71-75
25548525-12	2015	For maintenance therapy, gefitinib had an ICER of $19,214 per QALY, erlotinib had an ICER of $127,343 per LYG, and pemetrexed had an ICER varying between $183,589 and $205,597 per LYG.	Gefitinib	25-34	cAMP responsive element modulator	Homo sapiens	42-46
25548525-12	2015	For maintenance therapy, gefitinib had an ICER of $19,214 per QALY, erlotinib had an ICER of $127,343 per LYG, and pemetrexed had an ICER varying between $183,589 and $205,597 per LYG.	Erlotinib Hydrochloride	68-77	cAMP responsive element modulator	Homo sapiens	85-89
25548525-12	2015	For maintenance therapy, gefitinib had an ICER of $19,214 per QALY, erlotinib had an ICER of $127,343 per LYG, and pemetrexed had an ICER varying between $183,589 and $205,597 per LYG.	Erlotinib Hydrochloride	68-77	cAMP responsive element modulator	Homo sapiens	85-89
25319314-6	2014	The ICER of rivaroxaban versus warfarin was SG$29,697 (US$26,727) per QALY.	Rivaroxaban	12-23	cAMP responsive element modulator	Homo sapiens	4-8
25319314-9	2014	Deterministic sensitivity analyses showed that the ICER of rivaroxaban versus warfarin was sensitive to cost of rivaroxaban and utilities for rivaroxaban and warfarin.	Rivaroxaban	59-70	cAMP responsive element modulator	Homo sapiens	51-55
25319314-9	2014	Deterministic sensitivity analyses showed that the ICER of rivaroxaban versus warfarin was sensitive to cost of rivaroxaban and utilities for rivaroxaban and warfarin.	Warfarin	78-86	cAMP responsive element modulator	Homo sapiens	51-55
25319314-9	2014	Deterministic sensitivity analyses showed that the ICER of rivaroxaban versus warfarin was sensitive to cost of rivaroxaban and utilities for rivaroxaban and warfarin.	Rivaroxaban	112-123	cAMP responsive element modulator	Homo sapiens	51-55
25319314-9	2014	Deterministic sensitivity analyses showed that the ICER of rivaroxaban versus warfarin was sensitive to cost of rivaroxaban and utilities for rivaroxaban and warfarin.	Rivaroxaban	112-123	cAMP responsive element modulator	Homo sapiens	51-55
25319314-9	2014	Deterministic sensitivity analyses showed that the ICER of rivaroxaban versus warfarin was sensitive to cost of rivaroxaban and utilities for rivaroxaban and warfarin.	Warfarin	158-166	cAMP responsive element modulator	Homo sapiens	51-55
25313181-11	2014	The base-case ICER was $389K/QALY for abiraterone and $547K/QALY for sipuleucel-T. Prednisone dominates both abiraterone and sipuleucel-T in terms of NMB at willingness-to-pay (WTP) thresholds of $400K or less.	abiraterone	38-49	cAMP responsive element modulator	Homo sapiens	14-18
25313181-11	2014	The base-case ICER was $389K/QALY for abiraterone and $547K/QALY for sipuleucel-T. Prednisone dominates both abiraterone and sipuleucel-T in terms of NMB at willingness-to-pay (WTP) thresholds of $400K or less.	Prednisone	83-93	cAMP responsive element modulator	Homo sapiens	14-18
25313181-11	2014	The base-case ICER was $389K/QALY for abiraterone and $547K/QALY for sipuleucel-T. Prednisone dominates both abiraterone and sipuleucel-T in terms of NMB at willingness-to-pay (WTP) thresholds of $400K or less.	abiraterone	109-120	cAMP responsive element modulator	Homo sapiens	14-18
25241380-10	2014	RESULTS: This cost-effectiveness analysis produced an ICER of $3895/QALY for the base-case analysis (vs. warfarin) and of $6697/QALY for the real-world prescribing analysis (vs. mixed comparator).	Warfarin	105-113	cAMP responsive element modulator	Homo sapiens	54-58
24859238-0	2014	Generation of transgenic fibroblasts expressing pancreas-specific and doxycycline-inducible ICER Igamma for the establishment of a porcine model of human diabetes mellitus.	Doxycycline	70-81	cAMP responsive element modulator	Homo sapiens	92-96
24859238-1	2014	Inducible cyclic AMP (cAMP) early repressor (ICER) Igamma acts as an endogenous inhibitor and disrupts the transcriptional regulation of cAMP response element binding protein (CREBP) responsive genes.	Cyclic AMP	10-20	cAMP responsive element modulator	Homo sapiens	45-49
24859238-1	2014	Inducible cyclic AMP (cAMP) early repressor (ICER) Igamma acts as an endogenous inhibitor and disrupts the transcriptional regulation of cAMP response element binding protein (CREBP) responsive genes.	Cyclic AMP	22-26	cAMP responsive element modulator	Homo sapiens	45-49
24859238-1	2014	Inducible cyclic AMP (cAMP) early repressor (ICER) Igamma acts as an endogenous inhibitor and disrupts the transcriptional regulation of cAMP response element binding protein (CREBP) responsive genes.	Cyclic AMP	137-141	cAMP responsive element modulator	Homo sapiens	45-49
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	Doxycycline	43-54	cAMP responsive element modulator	Homo sapiens	71-75
24859238-3	2014	Using the human insulin promoter region, a doxycycline (dox)-inducible ICER Igamma expression system was established using the tetracycline (tet)-controlled transactivator (tTA) with a TA response element (TRE) promoter.	Doxycycline	43-46	cAMP responsive element modulator	Homo sapiens	71-75
24877251-10	2014	Duloxetine accumulated the highest number of quality-adjusted life years (QALYs), with an ICER of $36,291 per QALY versus celecoxib.	Duloxetine Hydrochloride	0-10	cAMP responsive element modulator	Homo sapiens	90-94
24973113-13	2014	The ICER for dabigatran was below $24,000/QALY or $36,000/QALY in 71% or 92%, respectively, of the simulations when compared with "trial-like" warfarin and 100% and 100%, respectively, when compared with "real-world" prescribing.	Dabigatran	13-23	cAMP responsive element modulator	Homo sapiens	4-8
24720775-17	2014	CONCLUSION: Solifenacin would appear to be cost-effective with an ICER of no more than $20,000/QALY.	Solifenacin Succinate	12-23	cAMP responsive element modulator	Homo sapiens	66-70
24935675-7	2014	RESULTS: The model estimated the ICER of apixaban versus warfarin amongst patients who are suitable for warfarin therapy to be SEK 33,458/QALY gained and that of apixaban versus aspirin amongst those unsuitable for warfarin therapy to be SEK 41,453/QALY gained.	apixaban	41-49	cAMP responsive element modulator	Homo sapiens	33-37
24935675-7	2014	RESULTS: The model estimated the ICER of apixaban versus warfarin amongst patients who are suitable for warfarin therapy to be SEK 33,458/QALY gained and that of apixaban versus aspirin amongst those unsuitable for warfarin therapy to be SEK 41,453/QALY gained.	Warfarin	57-65	cAMP responsive element modulator	Homo sapiens	33-37
24935675-7	2014	RESULTS: The model estimated the ICER of apixaban versus warfarin amongst patients who are suitable for warfarin therapy to be SEK 33,458/QALY gained and that of apixaban versus aspirin amongst those unsuitable for warfarin therapy to be SEK 41,453/QALY gained.	Warfarin	104-112	cAMP responsive element modulator	Homo sapiens	33-37
24935675-7	2014	RESULTS: The model estimated the ICER of apixaban versus warfarin amongst patients who are suitable for warfarin therapy to be SEK 33,458/QALY gained and that of apixaban versus aspirin amongst those unsuitable for warfarin therapy to be SEK 41,453/QALY gained.	Warfarin	104-112	cAMP responsive element modulator	Homo sapiens	33-37
24990105-7	2014	The M&T strategy costs US$20,730 per patient and yields a discounted QALY of 15.45, which represents incremental costs and health benefits of US$275 and 0.10 QALYs compared to current practice, and an ICER of US$2,996 per QALY gained.	Adenosine Monophosphate	6-9	cAMP responsive element modulator	Homo sapiens	205-209
24582461-7	2014	RESULTS: Extended duration rivaroxaban resulted in higher treatment costs ($22,645 vs. $22,083) but yielded greater QALYs (16.167 vs. 16.134) as compared to placebo; corresponding to an ICER of $17,030/QALY gained.	Rivaroxaban	27-38	cAMP responsive element modulator	Homo sapiens	186-190
24843377-1	2014	The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents" response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD).	Cyclic AMP	162-192	cAMP responsive element modulator	Homo sapiens	247-278
24843377-1	2014	The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents" response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and rs12775799 within cAMP response element-modulator (CREM) variants in bipolar disorder (BD) and major depressive disorder (MDD).	Cyclic AMP	162-192	cAMP responsive element modulator	Homo sapiens	280-284
23420082-7	2014	Mean total costs of treatment per patient and month were 1,015 $ under LAI-RIS and 395 $ under LAI-FLX, resulting in an ICER of 3,088 $ (95% CI [-913 $; 3,551 $]) for an avoided hospital day per patient and month in the base case scenario with a 15.1% probability of LAI-FLX being the dominant treatment strategy.	lai-flx	95-102	cAMP responsive element modulator	Homo sapiens	120-124
24252132-7	2014	RESULTS: Compared to no screening, the UDHQ avoids 0.02 TTB cases per 100,000 RBC transfusions at an ICER of $160,000/QALY whereas recipient risk-targeted strategy using antibody/PCR avoids 1.62 TTB cases per 100,000 RBC transfusions at an ICER of $713,000/QALY compared to the UDHQ.	udhq	39-43	cAMP responsive element modulator	Homo sapiens	101-105
24252132-7	2014	RESULTS: Compared to no screening, the UDHQ avoids 0.02 TTB cases per 100,000 RBC transfusions at an ICER of $160,000/QALY whereas recipient risk-targeted strategy using antibody/PCR avoids 1.62 TTB cases per 100,000 RBC transfusions at an ICER of $713,000/QALY compared to the UDHQ.	udhq	39-43	cAMP responsive element modulator	Homo sapiens	240-244
24125103-13	2014	Adjuvant lapatinib becomes cost-effective at the 0.879 hazard ratio where the ICER is $44 825/QALY.	Lapatinib	9-18	cAMP responsive element modulator	Homo sapiens	78-82
24670522-7	2014	The ICER of "PEG/RBV trial" compared with "dual therapy" was $37 500/QALY.	Polyethylene Glycols	13-16	cAMP responsive element modulator	Homo sapiens	4-8
24670522-7	2014	The ICER of "PEG/RBV trial" compared with "dual therapy" was $37 500/QALY.	Ribavirin	17-20	cAMP responsive element modulator	Homo sapiens	4-8
24438715-8	2014	RESULTS: On comparing the platinum-based group versus no chemotherapy, we found that the ICER was $30,073/QALY and $58,151/QALY for early- and late-stage disease, respectively, while other nonplatinum and platinum plus taxane groups were dominated (less effective and more costly).	Platinum	26-34	cAMP responsive element modulator	Homo sapiens	89-93
24672804-4	2014	ICER is an immediate early gene, which is rapidly induced by the cyclic AMP (cAMP) signaling cascade.	Cyclic AMP	65-75	cAMP responsive element modulator	Homo sapiens	0-4
24672804-4	2014	ICER is an immediate early gene, which is rapidly induced by the cyclic AMP (cAMP) signaling cascade.	Cyclic AMP	77-81	cAMP responsive element modulator	Homo sapiens	0-4
24672804-7	2014	Inappropriate induction of ICER accounts for pancreatic beta-cells dysfunction and ultimately death elicited by chronic hyperglycemia, fatty acids, and oxidized LDL.	Fatty Acids	135-146	cAMP responsive element modulator	Homo sapiens	27-31
24168919-8	2014	The ICER of PG-AC was 2843 USD/QALY.	pg-ac	12-17	cAMP responsive element modulator	Homo sapiens	4-8
24168919-9	2014	The ICER of PG-AC would exceed 50 000 USD/QALY if the monthly cost of NOAC was more than USD285 or the risk of stroke with NOAC versus warfarin was more than 0.93.	pg-ac	12-17	cAMP responsive element modulator	Homo sapiens	4-8
24168919-9	2014	The ICER of PG-AC would exceed 50 000 USD/QALY if the monthly cost of NOAC was more than USD285 or the risk of stroke with NOAC versus warfarin was more than 0.93.	N(4)-octadecyl-1-arabinofuranosylcytosine	70-74	cAMP responsive element modulator	Homo sapiens	4-8
24168919-9	2014	The ICER of PG-AC would exceed 50 000 USD/QALY if the monthly cost of NOAC was more than USD285 or the risk of stroke with NOAC versus warfarin was more than 0.93.	N(4)-octadecyl-1-arabinofuranosylcytosine	123-127	cAMP responsive element modulator	Homo sapiens	4-8
24168919-9	2014	The ICER of PG-AC would exceed 50 000 USD/QALY if the monthly cost of NOAC was more than USD285 or the risk of stroke with NOAC versus warfarin was more than 0.93.	Warfarin	135-143	cAMP responsive element modulator	Homo sapiens	4-8
24438715-8	2014	RESULTS: On comparing the platinum-based group versus no chemotherapy, we found that the ICER was $30,073/QALY and $58,151/QALY for early- and late-stage disease, respectively, while other nonplatinum and platinum plus taxane groups were dominated (less effective and more costly).	Platinum	192-200	cAMP responsive element modulator	Homo sapiens	89-93
24438715-8	2014	RESULTS: On comparing the platinum-based group versus no chemotherapy, we found that the ICER was $30,073/QALY and $58,151/QALY for early- and late-stage disease, respectively, while other nonplatinum and platinum plus taxane groups were dominated (less effective and more costly).	taxane	219-225	cAMP responsive element modulator	Homo sapiens	89-93
24438715-10	2014	For patients 85 years or older, platinum plus taxane, however, was not dominated by the platinum-based group, with an ICER of $133,892/QALY.	Platinum	32-40	cAMP responsive element modulator	Homo sapiens	118-122
24438715-10	2014	For patients 85 years or older, platinum plus taxane, however, was not dominated by the platinum-based group, with an ICER of $133,892/QALY.	taxane	46-52	cAMP responsive element modulator	Homo sapiens	118-122
24049452-11	2013	ICER for lurasidone versus risperidone was $25,884/relapse-related hospitalization avoided.	Lurasidone Hydrochloride	9-19	cAMP responsive element modulator	Homo sapiens	0-4
24100545-1	2013	Human cyclic AMP response modulator proteins (CREMs) are encoded by the CREM gene, which generates 30 or more different CREM protein isoforms.	Cyclic AMP	6-16	cAMP responsive element modulator	Homo sapiens	46-50
24100545-1	2013	Human cyclic AMP response modulator proteins (CREMs) are encoded by the CREM gene, which generates 30 or more different CREM protein isoforms.	Cyclic AMP	6-16	cAMP responsive element modulator	Homo sapiens	72-76
23701917-12	2013	Analysis of sputum mRNA suggested engagement of pharmacology, based on increased expression of cAMP-dependent genes including amphiregulin and CREM in subjects receiving GSK256066.	Cyclic AMP	95-99	cAMP responsive element modulator	Homo sapiens	143-147
23500045-8	2013	The results unambiguously show that the CREM sequence folds into a G-quadruplex structure in the presence of a physiological concentration of potassium ions.	Potassium	142-151	cAMP responsive element modulator	Homo sapiens	40-44
24000086-10	2013	According to the base-case analysis, using dual therapy as the comparator, the alternative IL28B-guided therapy presents a more favorable ICER ($18,079/QALY for boceprevir and $25,914/QALY for telaprevir) than the universal triple therapy option ($27,594/QALY for boceprevir and $33,751/QALY for telaprevir), with an ICER clearly below the efficiency threshold for medical interventions in the Spanish setting.	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	161-171	cAMP responsive element modulator	Homo sapiens	138-142
24000086-10	2013	According to the base-case analysis, using dual therapy as the comparator, the alternative IL28B-guided therapy presents a more favorable ICER ($18,079/QALY for boceprevir and $25,914/QALY for telaprevir) than the universal triple therapy option ($27,594/QALY for boceprevir and $33,751/QALY for telaprevir), with an ICER clearly below the efficiency threshold for medical interventions in the Spanish setting.	telaprevir	193-203	cAMP responsive element modulator	Homo sapiens	138-142
24000086-10	2013	According to the base-case analysis, using dual therapy as the comparator, the alternative IL28B-guided therapy presents a more favorable ICER ($18,079/QALY for boceprevir and $25,914/QALY for telaprevir) than the universal triple therapy option ($27,594/QALY for boceprevir and $33,751/QALY for telaprevir), with an ICER clearly below the efficiency threshold for medical interventions in the Spanish setting.	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	264-274	cAMP responsive element modulator	Homo sapiens	138-142
24000086-10	2013	According to the base-case analysis, using dual therapy as the comparator, the alternative IL28B-guided therapy presents a more favorable ICER ($18,079/QALY for boceprevir and $25,914/QALY for telaprevir) than the universal triple therapy option ($27,594/QALY for boceprevir and $33,751/QALY for telaprevir), with an ICER clearly below the efficiency threshold for medical interventions in the Spanish setting.	telaprevir	296-306	cAMP responsive element modulator	Homo sapiens	138-142
23663281-9	2013	RESULTS: Base case analyses revealed that agomelatine is a dominant therapy for MDD relative to escitalopram, fluoxetine and sertraline, and it appeared to be cost-effective compared to venlafaxine (ICER: $547/QALY).	agomelatine	42-53	cAMP responsive element modulator	Homo sapiens	199-203
23718933-12	2013	The ICER for RT/GC+GC was $97,799 per PF-LYS.	Lysine	41-44	cAMP responsive element modulator	Homo sapiens	4-8
23718933-15	2013	When the cost of chemotherapy was decreased by 50%, the ICER was below $50,000 at $41,774 per PF-LYS.	pf-lys	94-100	cAMP responsive element modulator	Homo sapiens	56-60
22113645-3	2013	CGRP inhibits effector functions of various immune cells and dampens inflammation by distinct pathways involving the amplification of IL-10 production and/or the induction of the transcriptional repressor inducible cAMP early repressor (ICER).	Cyclic AMP	215-219	cAMP responsive element modulator	Homo sapiens	237-241
23321266-18	2013	The CTA strategy was the most cost-effective strategy for minority accrual (ICER: US$908).	Chlorotrianisene	4-7	cAMP responsive element modulator	Homo sapiens	76-80
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	23-27
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	29-62
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	80-84
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	86-116
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Melatonin	166-175	cAMP responsive element modulator	Homo sapiens	23-27
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Melatonin	166-175	cAMP responsive element modulator	Homo sapiens	29-62
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Melatonin	166-175	cAMP responsive element modulator	Homo sapiens	80-84
23443664-2	2013	cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about its influence in other organs.	Melatonin	166-175	cAMP responsive element modulator	Homo sapiens	86-116
23443664-6	2013	The expression of both Icer and Per1 genes responded to cAMP stimuli in an immediate-early fashion.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	23-27
23443664-9	2013	Indeed, Per1 expression is up-regulated in cells ectopically expressing antisense Icer, and mobility shift experiments identified ICER binding to cAMP-responsive elements of the Per1 promoter.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	82-86
23443664-9	2013	Indeed, Per1 expression is up-regulated in cells ectopically expressing antisense Icer, and mobility shift experiments identified ICER binding to cAMP-responsive elements of the Per1 promoter.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	130-134
22414987-7	2013	Event-free survival gain per patient was 0.89 (range, 0.11-3.0) years in Bail-out SES with an NNT of 4.6 (CI: 2.5-25.6) and a corresponding ICER of 6,518<euro> (range 1,685-10,112<euro>).	Selenium	82-85	cAMP responsive element modulator	Homo sapiens	140-144
23538186-9	2013	RESULTS: The model estimated an ICER of $59,473 for duloxetine over naproxen.	Duloxetine Hydrochloride	52-62	cAMP responsive element modulator	Homo sapiens	32-36
23538186-9	2013	RESULTS: The model estimated an ICER of $59,473 for duloxetine over naproxen.	Naproxen	68-76	cAMP responsive element modulator	Homo sapiens	32-36
23538186-11	2013	In subpopulations at a higher risk of NSAID-related AEs, the ICER over naproxen was $33,105 or lower.	Naproxen	71-79	cAMP responsive element modulator	Homo sapiens	61-65
23329426-5	2013	It is argued that the CEAC is still a useful tool in describing and quantifying uncertainty around the ICER, especially in combination with other tools such as plots on the CE plane and value-of-information analysis.	ceac	22-26	cAMP responsive element modulator	Homo sapiens	103-107
23182811-6	2013	A series of one-way sensitivity analyses show that the ICER is most sensitive to the probability of achieving haemoglobin (Hb) targets using supplemental iron with a consequential decrease in the standard ESA doses and the relative increased risk in all-cause mortality associated with low Hb levels (Hb < 9.0 g/dL).	Iron	154-158	cAMP responsive element modulator	Homo sapiens	55-59
23331845-15	2013	CTCA appeared to be the most cost-effective strategy for patients with a negative troponin, with an ICER of $11,041/QALY.	ctca	0-4	cAMP responsive element modulator	Homo sapiens	100-104
22608115-7	2013	RESULTS: The main ICER was -$1244, indicating the societal economic gain for each additional case of remission when administering ICBT.	icbt	130-134	cAMP responsive element modulator	Homo sapiens	18-22
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Galantamine	119-131	cAMP responsive element modulator	Homo sapiens	16-20
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Tacrine	133-140	cAMP responsive element modulator	Homo sapiens	16-20
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Propidium	142-151	cAMP responsive element modulator	Homo sapiens	16-20
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Rivastigmine	157-169	cAMP responsive element modulator	Homo sapiens	16-20
22552298-2	2012	Recently, the overexpression of inducible cyclic AMP (cAMP) early repressor (ICER)             Igamma in rodent pancreatic beta cells was found to induce insulin deficiency and glucagon             overproduction similar to that found in human diabetes mellitus.	Cyclic AMP	42-52	cAMP responsive element modulator	Homo sapiens	77-81
23019580-6	2012	We demonstrate that cAMP response modulator (CREM)alpha contributes to epigenetic remodeling of IL2 in effector memory T cells through the recruitment of DNMT3a.	Cyclic AMP	20-24	cAMP responsive element modulator	Homo sapiens	45-49
22651881-8	2012	The ICER for rivaroxaban was $27,498 per QALY.	Rivaroxaban	13-24	cAMP responsive element modulator	Homo sapiens	4-8
22777393-6	2012	RESULTS: The ICER for men starting chemoprevention at age 50 and continuing to age 75 was $88 800 per QALY when assuming finasteride causes a constant risk reduction across all tumor grades (base case 1) and $142 300 per QALY when assuming a differential treatment effect according to Gleason score (base case 2).	Finasteride	121-132	cAMP responsive element modulator	Homo sapiens	13-17
22577748-13	2012	The estimated ICER for CAS versus CEA treatment was $229,429.	cas	23-26	cAMP responsive element modulator	Homo sapiens	14-18
22552298-2	2012	Recently, the overexpression of inducible cyclic AMP (cAMP) early repressor (ICER)             Igamma in rodent pancreatic beta cells was found to induce insulin deficiency and glucagon             overproduction similar to that found in human diabetes mellitus.	Cyclic AMP	54-58	cAMP responsive element modulator	Homo sapiens	77-81
22552298-2	2012	Recently, the overexpression of inducible cyclic AMP (cAMP) early repressor (ICER)             Igamma in rodent pancreatic beta cells was found to induce insulin deficiency and glucagon             overproduction similar to that found in human diabetes mellitus.	Glucagon	177-185	cAMP responsive element modulator	Homo sapiens	77-81
22552298-3	2012	ICER Igamma with             only a DNA binding domain interrupts the transcriptional regulation of the cAMP             responsive element-binding protein (CREB) target genes.	Cyclic AMP	104-108	cAMP responsive element modulator	Homo sapiens	0-4
22552298-7	2012	Second, ICER Igamma             overexpression controlled by this promoter region significantly blocked the glucose-mediated             insulin transcription, such as that regulated by the viral promoter in the pancreatic             beta cell line, MIN6.	Glucose	108-115	cAMP responsive element modulator	Homo sapiens	8-12
22386572-1	2012	Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders.	Cyclic AMP	74-104	cAMP responsive element modulator	Homo sapiens	187-218
22386572-1	2012	Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders.	Cyclic AMP	74-104	cAMP responsive element modulator	Homo sapiens	220-224
22386572-1	2012	Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders.	Cyclic AMP	106-110	cAMP responsive element modulator	Homo sapiens	187-218
22386572-1	2012	Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders.	Cyclic AMP	106-110	cAMP responsive element modulator	Homo sapiens	220-224
22510021-3	2012	Previous in vitro findings suggest that the cyclic AMP-response element (CRE) modulator (CREM) is involved in control of NIS expression.	Cyclic AMP	44-54	cAMP responsive element modulator	Homo sapiens	89-93
22678893-3	2012	cAMP facilitates the expression and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER), resulting in ICER-mediated suppression of interleukin-2 (IL-2).	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	92-122
22678893-3	2012	cAMP facilitates the expression and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER), resulting in ICER-mediated suppression of interleukin-2 (IL-2).	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	124-128
22678893-3	2012	cAMP facilitates the expression and nuclear function of a potent transcriptional inhibitor, inducible cAMP early repressor (ICER), resulting in ICER-mediated suppression of interleukin-2 (IL-2).	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	144-148
22253417-6	2012	Conversely, overexpression of CREM and YY1 in COS-1 cells resulted in transactivation of STAR reporter gene activity.	carbonyl sulfide	46-49	cAMP responsive element modulator	Homo sapiens	30-34
22531917-4	2012	PGE(2) coupling through EP2 activated the transcription factor inducible cAMP early repressor (ICER), whereas coupling through EP4 receptors activated the cyclic AMP-responsive element-binding protein (CREB).	Prostaglandins E	0-3	cAMP responsive element modulator	Homo sapiens	63-93
22531917-4	2012	PGE(2) coupling through EP2 activated the transcription factor inducible cAMP early repressor (ICER), whereas coupling through EP4 receptors activated the cyclic AMP-responsive element-binding protein (CREB).	Prostaglandins E	0-3	cAMP responsive element modulator	Homo sapiens	95-99
22304338-8	2012	Olanzapine ODT was more cost-effective than olanzapine SOT (ICER: $19,643), more cost-effective than risperidone SOT therapy (ICER: $39,966), and dominant (meaning less costly and more effective) than risperidone ODT and aripiprazole in ODT or SOT formulations.	olanzapine odt	0-14	cAMP responsive element modulator	Homo sapiens	60-64
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	102-106
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	187-191
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	102-106
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	187-191
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	102-106
22044735-1	2012	ICERs proteins (Inducible cAMP Early Repressors) are the most effective endogenous repressors of CREB/CREM/ATF transcription factors family (CREB-cAMP Responsive Element Binding protein, CREM-cAMP Responsive Element Modulator, ATF-Activating Transcription Factor) that have repeatedly been shown to have a prosurvival function.	Cyclic AMP	146-150	cAMP responsive element modulator	Homo sapiens	187-191
22332706-10	2012	For patients receiving 156 mg paliperidone palmitate, the annual incremental cost was $1216 per patient (ICER = $191 per day of relapse averted).	Paliperidone Palmitate	30-52	cAMP responsive element modulator	Homo sapiens	105-109
22332706-11	2012	Inclusion of generic risperidone (market share 18.6%) also resulted in net incremental cost for paliperidone palmitate ($120; ICER = $13).	Risperidone	21-32	cAMP responsive element modulator	Homo sapiens	126-130
22332706-11	2012	Inclusion of generic risperidone (market share 18.6%) also resulted in net incremental cost for paliperidone palmitate ($120; ICER = $13).	Paliperidone Palmitate	96-118	cAMP responsive element modulator	Homo sapiens	126-130
22834986-11	2012	RESULTS: For liraglutide 1.8 mg vs sitagliptin, the ICER was $37,234 per QALY gained, while for liraglutide 1.2 mg vs sitagliptin, the ICER was $25,742 per QALY gained.	Sitagliptin Phosphate	35-46	cAMP responsive element modulator	Homo sapiens	52-56
22136303-13	2012	The ICER for dronedarone relative to class 1c agents was around $19,000 per QALY.	Dronedarone	13-24	cAMP responsive element modulator	Homo sapiens	4-8
21325296-1	2011	PURPOSE: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is found downregulated in acute myeloid leukemia (AML), failing to control cAMP response element binding protein (CREB) transcriptional activity, recently demonstrated to mediate AML progression.	Cyclic AMP	55-59	cAMP responsive element modulator	Homo sapiens	78-82
21642009-0	2011	Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.	Nitric Oxide	0-12	cAMP responsive element modulator	Homo sapiens	79-109
21642009-4	2011	Many of the genes, whose expression was induced by GSNO, contain a cAMP-response element (CRE), of which one encoded the inducible cAMP early repressor (ICER).	S-Nitrosoglutathione	51-55	cAMP responsive element modulator	Homo sapiens	121-158
21642009-4	2011	Many of the genes, whose expression was induced by GSNO, contain a cAMP-response element (CRE), of which one encoded the inducible cAMP early repressor (ICER).	Cyclic AMP	67-71	cAMP responsive element modulator	Homo sapiens	121-158
21642009-7	2011	Pre-treatment of RPaSMC with the intracellular calcium (Ca(2+)) chelator, BAPTA-AM, blocked the induction of ICER gene expression by GSNO.	Calcium	47-54	cAMP responsive element modulator	Homo sapiens	109-113
21642009-7	2011	Pre-treatment of RPaSMC with the intracellular calcium (Ca(2+)) chelator, BAPTA-AM, blocked the induction of ICER gene expression by GSNO.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	74-82	cAMP responsive element modulator	Homo sapiens	109-113
21642009-7	2011	Pre-treatment of RPaSMC with the intracellular calcium (Ca(2+)) chelator, BAPTA-AM, blocked the induction of ICER gene expression by GSNO.	S-Nitrosoglutathione	133-137	cAMP responsive element modulator	Homo sapiens	109-113
21642009-8	2011	The store-operated Ca(2+) channel inhibitors, 2-ABP, and SKF-96365, reduced the GSNO-mediated increase in ICER mRNA levels, while 2-ABP did not inhibit GSNO-induced CREB phosphorylation.	S-Nitrosoglutathione	80-84	cAMP responsive element modulator	Homo sapiens	106-110
21642009-11	2011	The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways.	S-Nitrosoglutathione	25-29	cAMP responsive element modulator	Homo sapiens	17-21
21642009-11	2011	The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways.	Cyclic GMP	93-97	cAMP responsive element modulator	Homo sapiens	17-21
21642009-11	2011	The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways.	Cyclic AMP	102-106	cAMP responsive element modulator	Homo sapiens	17-21
21362464-6	2011	When exposing DC to DNFB versus lipopolysaccharide S (LPS), expression of most discriminating genes CREM and CCR2 was not altered by LPS as opposed to DNFB.	Dinitrofluorobenzene	20-24	cAMP responsive element modulator	Homo sapiens	100-104
22745801-10	2012	ICER of dabigatran 150 mg versus genotype-guided AC would be >USD50,000 (and genotype-guided AC would be most cost-effective) when TTR in genotype-guided AC was >77% and utility value of warfarin was the same or higher than that of dabigatran.	Dabigatran	8-18	cAMP responsive element modulator	Homo sapiens	0-4
22745801-10	2012	ICER of dabigatran 150 mg versus genotype-guided AC would be >USD50,000 (and genotype-guided AC would be most cost-effective) when TTR in genotype-guided AC was >77% and utility value of warfarin was the same or higher than that of dabigatran.	Warfarin	193-201	cAMP responsive element modulator	Homo sapiens	0-4
22745801-10	2012	ICER of dabigatran 150 mg versus genotype-guided AC would be >USD50,000 (and genotype-guided AC would be most cost-effective) when TTR in genotype-guided AC was >77% and utility value of warfarin was the same or higher than that of dabigatran.	Dabigatran	238-248	cAMP responsive element modulator	Homo sapiens	0-4
22264977-7	2012	For anastrazole compared to tamoxifen, incremental life-years gained even ranged from 0.16 to 0.550 with an ICER ranging from $3,958 to $75,331.	Anastrozole	4-15	cAMP responsive element modulator	Homo sapiens	108-112
22264977-7	2012	For anastrazole compared to tamoxifen, incremental life-years gained even ranged from 0.16 to 0.550 with an ICER ranging from $3,958 to $75,331.	Tamoxifen	28-37	cAMP responsive element modulator	Homo sapiens	108-112
21998402-9	2011	Silencing the expression of Icer in 3T3-L1 adipocytes mimicked the results observed in human and mice cells and hampered glucose uptake, thus confirming the requirement of Icer for appropriate adipocyte function.	Glucose	121-128	cAMP responsive element modulator	Homo sapiens	28-32
21547497-11	2011	Induction of ICER was stimulated by oxidative stress, whereas antioxidant treatment with N-acetylcysteine or HDL prevented the rise of ICER elicited by oxidised LDL and restored beta cell functions.	Acetylcysteine	89-105	cAMP responsive element modulator	Homo sapiens	135-139
21615437-10	2011	ASA plus PPI was also more costly than ASA alone, with an ICER of $19000 per life-year saved.	Aspirin	0-3	cAMP responsive element modulator	Homo sapiens	58-62
21719243-2	2011	The primary effectors of this pathway are members of the cAMP response element binding (CREB) family of transcription factors, in particular the CREB-1 and cAMP response element modulator (CREM).	Cyclic AMP	57-61	cAMP responsive element modulator	Homo sapiens	156-187
21719243-2	2011	The primary effectors of this pathway are members of the cAMP response element binding (CREB) family of transcription factors, in particular the CREB-1 and cAMP response element modulator (CREM).	Cyclic AMP	57-61	cAMP responsive element modulator	Homo sapiens	189-193
21196940-8	2011	However, two patients exhibited altered methylation of the CREM gene, which may be either causative or a result of abnormal protmaine replacement.	protmaine	124-133	cAMP responsive element modulator	Homo sapiens	59-63
21325296-1	2011	PURPOSE: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is found downregulated in acute myeloid leukemia (AML), failing to control cAMP response element binding protein (CREB) transcriptional activity, recently demonstrated to mediate AML progression.	Cyclic AMP	23-53	cAMP responsive element modulator	Homo sapiens	78-82
21627338-14	2011	When compared with DFP, the ICER of DFX was $US106 445 per QALY.	Deferasirox	36-39	cAMP responsive element modulator	Homo sapiens	28-32
20228061-5	2010	Isobutylmethylxanthine-dependent activation of protein kinase A triggered the phosphorylation of the transcription factor cAMP-response element-binding protein, which induced the expression of the cAMP-response element-binding protein family repressor cAMP-response element modulator.	Cyclic AMP	122-126	cAMP responsive element modulator	Homo sapiens	252-283
20498303-6	2010	The altered genomic regions showed an overrepresentation of cis-binding sites for ETS and cyclic adenosine monophosphate response elements (CREs) for transcription factors of the CREB/CREM/ATF1 family.	Cyclic AMP	90-120	cAMP responsive element modulator	Homo sapiens	184-188
20925454-11	2010	In case of a 35% reimbursement rate for PHF-W, the ICER was $615 from the MOH perspective, while the use of PHF-W was cost neutral at 10% reimbursement.	phf	40-43	cAMP responsive element modulator	Homo sapiens	51-55
20925454-11	2010	In case of a 35% reimbursement rate for PHF-W, the ICER was $615 from the MOH perspective, while the use of PHF-W was cost neutral at 10% reimbursement.	Tungsten	44-45	cAMP responsive element modulator	Homo sapiens	51-55
20038515-8	2010	If the price of taxane decreased slightly, the ICER would reach some very reasonable levels and this strategy would therefore be much more cost-effective.	taxane	16-22	cAMP responsive element modulator	Homo sapiens	47-51
20228061-5	2010	Isobutylmethylxanthine-dependent activation of protein kinase A triggered the phosphorylation of the transcription factor cAMP-response element-binding protein, which induced the expression of the cAMP-response element-binding protein family repressor cAMP-response element modulator.	Cyclic AMP	197-201	cAMP responsive element modulator	Homo sapiens	252-283
19719912-7	2009	According to national economic burden of CHB-related diseases, the ICER with telbivudine vs lamivudine were 1282 yuan and 31565 yuan for HBeAg-positive and -negative CHB.	Telbivudine	77-88	cAMP responsive element modulator	Homo sapiens	67-71
20507802-11	2010	In the revised model, alitretinoin was reported to have an ICER of 12,931 pounds per QALY gained versus supportive care (placebo).	Alitretinoin	22-34	cAMP responsive element modulator	Homo sapiens	59-63
19543827-2	2009	To determine whether endogenous ICER production represses CRH transcription, we examined the effect of CREM siRNA on forskolin-stimulated ICER formation and CRH transcription in the hypothalamic cell line, 4B, and in primary cultures of hypothalamic neurons.	Colforsin	117-126	cAMP responsive element modulator	Homo sapiens	103-107
19543827-2	2009	To determine whether endogenous ICER production represses CRH transcription, we examined the effect of CREM siRNA on forskolin-stimulated ICER formation and CRH transcription in the hypothalamic cell line, 4B, and in primary cultures of hypothalamic neurons.	Colforsin	117-126	cAMP responsive element modulator	Homo sapiens	138-142
19543827-3	2009	Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide.	Colforsin	136-145	cAMP responsive element modulator	Homo sapiens	32-36
19543827-3	2009	Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide.	Colforsin	136-145	cAMP responsive element modulator	Homo sapiens	128-132
19543827-3	2009	Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide.	Colforsin	188-197	cAMP responsive element modulator	Homo sapiens	32-36
19543827-3	2009	Cotransfection of 4B cells with CREM siRNA and a CRH promoter-driven luciferase reporter gene markedly reduced the induction of ICER by forskolin and potentiated the stimulatory effect of forskolin on CRH promoter activity, compared with cells cotransfected with a nonspecific oligonucleotide.	Oligonucleotides	277-292	cAMP responsive element modulator	Homo sapiens	32-36
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	35-44	cAMP responsive element modulator	Homo sapiens	164-168
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	35-44	cAMP responsive element modulator	Homo sapiens	201-205
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	35-44	cAMP responsive element modulator	Homo sapiens	347-351
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	35-44	cAMP responsive element modulator	Homo sapiens	347-351
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	183-192	cAMP responsive element modulator	Homo sapiens	164-168
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	183-192	cAMP responsive element modulator	Homo sapiens	201-205
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	183-192	cAMP responsive element modulator	Homo sapiens	347-351
19543827-5	2009	As observed during stress in vivo, forskolin-stimulated CRH hnRNA was transient, increasing up to 60 min and declining to near basal values by 3 h. Transfection of CREM siRNA reduced forskolin-induced ICER by about 45% 48-h later and partially reversed the declining phase of CRH hnRNA production at 3 h. The data provide evidence that endogenous ICER formation is required for termination of CRH transcription and support the hypothesis that ICER is part of an intracellular feedback mechanism limiting the activation of CRH transcription during stress.	Colforsin	183-192	cAMP responsive element modulator	Homo sapiens	347-351
19434522-1	2009	The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family.	Cyclic AMP	14-18	cAMP responsive element modulator	Homo sapiens	36-40
19434522-1	2009	The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family.	Cyclic AMP	14-18	cAMP responsive element modulator	Homo sapiens	191-195
20426644-10	2010	The estimated median ICER for CAS versus CEA treatment was $67,891 (-$129,372 to $379,661).	cas	30-33	cAMP responsive element modulator	Homo sapiens	21-25
20018859-5	2010	Dendritic cell expression of ICER was selectively induced by CGRP and elevation of cellular cAMP levels but not by numerous pro- and anti-inflammatory cytokines.	Cyclic AMP	92-96	cAMP responsive element modulator	Homo sapiens	29-33
19933991-9	2010	RESULTS: Excluding stroke, DCP patients lived longer (0.14 life-years, P = NS), experienced more QALYs (0.037, P = NS), and incurred higher total costs (euro 1,415, P = NS), resulting in an ICER of euro 38,243 per QALY gained.	dcp	27-30	cAMP responsive element modulator	Homo sapiens	190-194
19933991-11	2010	DCP had a more favorable effect on CVD+ patients (ICER = euro 14,814) than for CVD- patients (ICER = euro 121,285).	dcp	0-3	cAMP responsive element modulator	Homo sapiens	50-54
19933991-11	2010	DCP had a more favorable effect on CVD+ patients (ICER = euro 14,814) than for CVD- patients (ICER = euro 121,285).	dcp	0-3	cAMP responsive element modulator	Homo sapiens	94-98
20131924-17	2010	Although the ICERs estimated by the manufacturer suggested that alitretinoin may be cost effective for use in the UK NHS, utilizing the alternative HR-QOL estimates resulted in a 2-fold increase in the ICER.	Alitretinoin	64-76	cAMP responsive element modulator	Homo sapiens	13-17
20131924-18	2010	Thus, there was considerable uncertainty as to the true ICER of alitretinoin versus the relevant treatment comparators.	Alitretinoin	64-76	cAMP responsive element modulator	Homo sapiens	56-60
19846022-11	2009	In sensitivity analyses the ICER for lapatinib plus capecitabine compared with capecitabine monotherapy or vinorelbine monotherapy was robust to variation in assumptions.	Lapatinib	37-46	cAMP responsive element modulator	Homo sapiens	28-32
19846022-11	2009	In sensitivity analyses the ICER for lapatinib plus capecitabine compared with capecitabine monotherapy or vinorelbine monotherapy was robust to variation in assumptions.	Capecitabine	52-64	cAMP responsive element modulator	Homo sapiens	28-32
19719912-8	2009	CONCLUSION: According to WHO recommendation for ICER threshold, telbivudine is cost effective in treating HBeAg-positive and -negative CHB, as compared to lamivudine.	Telbivudine	64-75	cAMP responsive element modulator	Homo sapiens	48-52
19284806-8	2009	RESULTS: The ICER for continuous oxygen therapy ($16,124 per quality-adjusted life-year [QALY]) was within bounds considered to be cost-effective, while that of nocturnal oxygen therapy was not ($306,356/QALY).	Oxygen	33-39	cAMP responsive element modulator	Homo sapiens	13-17
19552590-11	2009	The ICER of raltegravir + OBT vs. OBT alone was euro22,908/QALY and euro31,431/QALY for 3- and 5-year use, respectively.	Raltegravir Potassium	12-23	cAMP responsive element modulator	Homo sapiens	4-8
19573471-15	2009	The ICER of 12 months" treatment with clopidogrel varied between 49,436 pounds and 58,691 pounds per QALY.	Clopidogrel	38-49	cAMP responsive element modulator	Homo sapiens	4-8
19150388-6	2009	The expression and activities of CREB/CREM/ATF, Fos/Jun and C/EBPbeta have been demonstrated to be mediated by a plethora of extracellular signals, and the phosphorylation of these proteins at several Ser and Thr residues allows recruitment of the transcriptional coactivator CREB binding protein (CBP) or its functional homolog p300 to the StAR promoter.	Serine	201-204	cAMP responsive element modulator	Homo sapiens	38-42
19150388-6	2009	The expression and activities of CREB/CREM/ATF, Fos/Jun and C/EBPbeta have been demonstrated to be mediated by a plethora of extracellular signals, and the phosphorylation of these proteins at several Ser and Thr residues allows recruitment of the transcriptional coactivator CREB binding protein (CBP) or its functional homolog p300 to the StAR promoter.	Threonine	209-212	cAMP responsive element modulator	Homo sapiens	38-42
19366302-12	2009	QALYs increased by 0.475 years with detemir, with an ICER of $CAN 24 389/QALY.	Insulin Detemir	36-43	cAMP responsive element modulator	Homo sapiens	53-57
19018778-4	2009	These genes included a suppressor of cytokine signalling (SOCS1) and a modulator of cAMP response elements (CREM).	Cyclic AMP	84-88	cAMP responsive element modulator	Homo sapiens	108-112
19284806-9	2009	The estimated ICER for continuous oxygen therapy was robust (95% confidence interval, $13,153-$24,658/QALY) and was more favorable than the ICERs for commonly used medical and surgical therapies for chronic obstructive pulmonary disease.	Oxygen	34-40	cAMP responsive element modulator	Homo sapiens	14-18
19284806-10	2009	The ICER for nocturnal oxygen therapy was sensitive to variation in the mortality rate; it could be as low as $18,267/QALY gained.	Oxygen	23-29	cAMP responsive element modulator	Homo sapiens	4-8
18992303-5	2009	The prolonged culture in high glucose increased inducible cAMP early repressor (ICER) II mRNA and protein levels, and overexpression of ICER II dose-dependently suppressed promoter activities of IL-2, NFAT, and AP-1.	Glucose	30-37	cAMP responsive element modulator	Homo sapiens	80-84
18992303-5	2009	The prolonged culture in high glucose increased inducible cAMP early repressor (ICER) II mRNA and protein levels, and overexpression of ICER II dose-dependently suppressed promoter activities of IL-2, NFAT, and AP-1.	Cyclic AMP	58-62	cAMP responsive element modulator	Homo sapiens	80-84
18992303-6	2009	Moreover, ICER II mRNA expression was transiently induced by stimulation with PMA and ionomycin in normal glucose cultures; however, with high glucose, the induction disappeared.	Tetradecanoylphorbol Acetate	78-81	cAMP responsive element modulator	Homo sapiens	10-14
18992303-6	2009	Moreover, ICER II mRNA expression was transiently induced by stimulation with PMA and ionomycin in normal glucose cultures; however, with high glucose, the induction disappeared.	Ionomycin	86-95	cAMP responsive element modulator	Homo sapiens	10-14
18992303-6	2009	Moreover, ICER II mRNA expression was transiently induced by stimulation with PMA and ionomycin in normal glucose cultures; however, with high glucose, the induction disappeared.	Glucose	106-113	cAMP responsive element modulator	Homo sapiens	10-14
18992303-6	2009	Moreover, ICER II mRNA expression was transiently induced by stimulation with PMA and ionomycin in normal glucose cultures; however, with high glucose, the induction disappeared.	Glucose	143-150	cAMP responsive element modulator	Homo sapiens	10-14
18992303-7	2009	CONCLUSION: These results indicate that ICER II protein accumulates during prolonged culture in high glucose and suppresses IL-2 mRNA expression in Jurkat cells.	Glucose	101-108	cAMP responsive element modulator	Homo sapiens	40-44
18922788-4	2008	BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.	Cyclic AMP	63-92	cAMP responsive element modulator	Homo sapiens	154-158
18717821-7	2008	CT transcriptionally downregulates the AMPs by activating several intracellular signalling pathways involving protein kinase A (PKA), ERK MAPKinase and Cox-2 downstream of cAMP accumulation and inducible cAMP early repressor (ICER) may mediate this role of CT, at least in part.	Adenylyl sulfate	39-43	cAMP responsive element modulator	Homo sapiens	226-230
18717821-7	2008	CT transcriptionally downregulates the AMPs by activating several intracellular signalling pathways involving protein kinase A (PKA), ERK MAPKinase and Cox-2 downstream of cAMP accumulation and inducible cAMP early repressor (ICER) may mediate this role of CT, at least in part.	Cyclic AMP	204-208	cAMP responsive element modulator	Homo sapiens	226-230
18826750-11	2008	The ICER for pioglitazone treatment was $20 171/QALY.	Pioglitazone	13-25	cAMP responsive element modulator	Homo sapiens	4-8
18922788-4	2008	BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.	Cyclic AMP	94-98	cAMP responsive element modulator	Homo sapiens	160-190
18922788-4	2008	BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.	Cyclic AMP	63-92	cAMP responsive element modulator	Homo sapiens	160-190
18922788-4	2008	BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.	Cyclic AMP	94-98	cAMP responsive element modulator	Homo sapiens	154-158
18691996-6	2008	Compared with pravastatin 20 mg, the ICER per percent reduction in LDL-C, TC/HDL-C ratio, TC, TG, ApoB, or ApoB/ApoA-I or increase in HDL-C ranged from $3.89 to $26.07; the value for 1 additional patient achieving the LDL-C goal was $419.75.	Pravastatin	14-25	cAMP responsive element modulator	Homo sapiens	37-41
18725849-7	2008	RESULTS: Inclusion of a utility for menopausal symptoms in the outcome-specific models substantially increased the ICER; at the threshold 5-year breast cancer risk of 1.67%, tamoxifen was dominated.	Tamoxifen	174-183	cAMP responsive element modulator	Homo sapiens	115-119
18691996-6	2008	Compared with pravastatin 20 mg, the ICER per percent reduction in LDL-C, TC/HDL-C ratio, TC, TG, ApoB, or ApoB/ApoA-I or increase in HDL-C ranged from $3.89 to $26.07; the value for 1 additional patient achieving the LDL-C goal was $419.75.	Technetium	74-76	cAMP responsive element modulator	Homo sapiens	37-41
18691996-6	2008	Compared with pravastatin 20 mg, the ICER per percent reduction in LDL-C, TC/HDL-C ratio, TC, TG, ApoB, or ApoB/ApoA-I or increase in HDL-C ranged from $3.89 to $26.07; the value for 1 additional patient achieving the LDL-C goal was $419.75.	Triglycerides	94-96	cAMP responsive element modulator	Homo sapiens	37-41
17189071-5	2007	RESULTS: Relative to no treatment, RT-FU was associated with a cost-effectiveness ratio (ICER) of $68,724/QALY in the base case analysis.	rt-fu	35-40	cAMP responsive element modulator	Homo sapiens	89-93
18180303-0	2008	Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.	Cyclic AMP	90-94	cAMP responsive element modulator	Homo sapiens	152-182
18180303-7	2008	Decrease of alpha1 is dependent upon the inducible cAMP early repressor (ICER) as directly demonstrated by ICER-induced down-regulation of endogenous alpha1-containing GABA(A)Rs at the cell surface of cortical neurons.	gamma-Aminobutyric Acid	168-172	cAMP responsive element modulator	Homo sapiens	41-71
18180303-7	2008	Decrease of alpha1 is dependent upon the inducible cAMP early repressor (ICER) as directly demonstrated by ICER-induced down-regulation of endogenous alpha1-containing GABA(A)Rs at the cell surface of cortical neurons.	gamma-Aminobutyric Acid	168-172	cAMP responsive element modulator	Homo sapiens	73-77
18180303-7	2008	Decrease of alpha1 is dependent upon the inducible cAMP early repressor (ICER) as directly demonstrated by ICER-induced down-regulation of endogenous alpha1-containing GABA(A)Rs at the cell surface of cortical neurons.	gamma-Aminobutyric Acid	168-172	cAMP responsive element modulator	Homo sapiens	107-111
18180303-8	2008	Taken together with the fact that there are less alpha1gamma2-containing GABA(A)Rs in neurons after protein kinase A stimulation and that activation of endogenous dopamine receptors down-regulates alpha1 subunit mRNA levels subsequent to induction of ICER, our studies identify a transcriptional mechanism for regulating the cell surface expression of alpha1-containing GABA(A)Rs that is dependent upon the formation of CREB heterodimers.	gamma-Aminobutyric Acid	370-374	cAMP responsive element modulator	Homo sapiens	251-255
17903394-15	2007	Assumptions regarding the benefits in the taxane arm after the trial follow-up period and the annual rate of recurrence in this period have the most significant influence on the ICER.	taxane	42-48	cAMP responsive element modulator	Homo sapiens	178-182
17712720-10	2007	ICER reduced basal luciferase activity in Y1 cells by 17+/-28%, but completely abolished forskolin stimulation.	Colforsin	89-98	cAMP responsive element modulator	Homo sapiens	0-4
17712720-13	2007	We conclude from these data that transcription factors of the CREB/CREM/ATF family have a moderate effect on human MC2-R promoter activity, but seem to play a minor role in transmitting stimulation of the cAMP pathway to increased MC2-R expression.	Cyclic AMP	205-209	cAMP responsive element modulator	Homo sapiens	67-71
17463330-3	2007	METHODS AND RESULTS: Semi-quantitative RT-PCR and Western blot analysis showed that expression of ICER was increased in beraprost (a prostaglandin I2 analogue)-stimulated VSMCs in a time- and dose-dependent manner.	Epoprostenol	133-149	cAMP responsive element modulator	Homo sapiens	98-102
17463330-5	2007	Beraprost suppressed platelet-derived growth factor-induced thymidine incorporation in VSMCs, which was reversed by transfection of short interfering RNA for ICER, not by scramble RNA.	Thymidine	60-69	cAMP responsive element modulator	Homo sapiens	158-162
17463330-7	2007	The number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling-positive cells was increased and the number of Ki-67-positive cells was decreased in ICER-transduced artery.	deoxyuridine triphosphate	61-65	cAMP responsive element modulator	Homo sapiens	169-173
17372992-1	2007	Here, we report that inducible cAMP early repressor/cAMP response element modulator (ICER/CREM) is induced early in CD25(+)CD4(+) regulatory T cell (T(R)) assays mainly in activated Foxp3(-) effector T cells and this induction correlates with sharp decrease in number of IL-2-expressing T cells.	Cyclic AMP	31-35	cAMP responsive element modulator	Homo sapiens	52-83
17372992-1	2007	Here, we report that inducible cAMP early repressor/cAMP response element modulator (ICER/CREM) is induced early in CD25(+)CD4(+) regulatory T cell (T(R)) assays mainly in activated Foxp3(-) effector T cells and this induction correlates with sharp decrease in number of IL-2-expressing T cells.	Cyclic AMP	31-35	cAMP responsive element modulator	Homo sapiens	85-89
17372992-1	2007	Here, we report that inducible cAMP early repressor/cAMP response element modulator (ICER/CREM) is induced early in CD25(+)CD4(+) regulatory T cell (T(R)) assays mainly in activated Foxp3(-) effector T cells and this induction correlates with sharp decrease in number of IL-2-expressing T cells.	Cyclic AMP	31-35	cAMP responsive element modulator	Homo sapiens	90-94
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Morphine	29-37	cAMP responsive element modulator	Homo sapiens	182-186
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Morphine	29-37	cAMP responsive element modulator	Homo sapiens	188-219
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Morphine	29-37	cAMP responsive element modulator	Homo sapiens	221-225
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	74-78	cAMP responsive element modulator	Homo sapiens	182-186
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	182-186
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	188-219
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	221-225
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	182-186
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	188-219
17227776-4	2007	Herein, we show that chronic morphine treatment results in an increase in cAMP levels with a concurrent up-regulation of the cAMP inducible repressor inducible cAMP early repressor (ICER)/cAMP response element modulator (CREM) and down-regulation of p-cAMP-response element-binding protein (CREB) in activated T cells.	Cyclic AMP	125-129	cAMP responsive element modulator	Homo sapiens	221-225
17227776-5	2007	Furthermore, ICER competes for p-CREB binding to the cAMP-responsive elements (CREs) site.	Cyclic AMP	53-57	cAMP responsive element modulator	Homo sapiens	13-17
17169345-3	2007	Here we found that transient expression of a CREB dominant interfering mutant A-CREB or the inducible cAMP early repressor, ICER, led to the dramatic decrease of exogenously co-expressed CREB in 293 human embryonic kidney cells.	Cyclic AMP	102-106	cAMP responsive element modulator	Homo sapiens	124-128
18179662-5	2008	RESULTS: The ICER for clozapine was 33,240 pound per quality-adjusted life-year (QALY) (range 23,000-70,000 pound for the sensitivity analyses).	Clozapine	22-31	cAMP responsive element modulator	Homo sapiens	13-17
18373637-8	2008	However, a 5 on-1 off strategy was the most cost-effective: lifetime vs. 5 on-1 off entecavir had an ICER of $148,200/QALY.	entecavir	84-93	cAMP responsive element modulator	Homo sapiens	101-105
18431519-6	2008	Mechanistically, kinetin riboside upregulated expression of transcription repressor isoforms of cAMP-response element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes and cis-activation of translocated CCND1, suggesting induction of an overriding repressor activity that blocks multiple oncogenic pathways targeting cyclin D genes.	riboside	25-33	cAMP responsive element modulator	Homo sapiens	96-127
18431519-6	2008	Mechanistically, kinetin riboside upregulated expression of transcription repressor isoforms of cAMP-response element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes and cis-activation of translocated CCND1, suggesting induction of an overriding repressor activity that blocks multiple oncogenic pathways targeting cyclin D genes.	riboside	25-33	cAMP responsive element modulator	Homo sapiens	129-133
17698383-2	2007	The change lies in a cAMP response element (CRE) and alters a binding site for the CREM transcription factor.	Cyclic AMP	21-25	cAMP responsive element modulator	Homo sapiens	83-87
17340624-2	2007	ICER is proposed to downregulate both its own expression, and the expression of other genes, containing cAMP-responsive promoter elements.	Cyclic AMP	104-108	cAMP responsive element modulator	Homo sapiens	0-4
17340624-8	2007	ICER I and IIgamma also repress cAMP-mediated activation of chromogranin A (CgA), indicating that these splice variants may function as negative feedback regulators in CgA synthesis.	Cyclic AMP	32-36	cAMP responsive element modulator	Homo sapiens	0-4
17227776-7	2007	Overexpression of either antisense CREM or CREB plasmid rescued morphine-induced inhibition of IL-2 promoter activity and protein production.	Morphine	64-72	cAMP responsive element modulator	Homo sapiens	35-39
17325142-11	2007	The ICER comparing atropine to the combined regimen was 1.81 (95% CI = -6.31-15.35) and compared to cyclopentolate was 0.59 (95% CI = -3.47-5.47).	Atropine	19-27	cAMP responsive element modulator	Homo sapiens	4-8
17313682-15	2007	When the costs of second line treatment are considered the ICER of AL becomes negative, indicating that there are greater resource savings associated with AL in terms of reduction of costs of complicated malaria treatment.	Aluminum	67-69	cAMP responsive element modulator	Homo sapiens	59-63
17313682-15	2007	When the costs of second line treatment are considered the ICER of AL becomes negative, indicating that there are greater resource savings associated with AL in terms of reduction of costs of complicated malaria treatment.	Aluminum	155-157	cAMP responsive element modulator	Homo sapiens	59-63
17189071-8	2007	The ICER of RT-GEM was most sensitive to utility values, and, at lower efficacy levels, to costs of gemcitabine and treatment-related toxicity.	gemcitabine	100-111	cAMP responsive element modulator	Homo sapiens	4-8
17056544-2	2006	cAMP response element (CRE) modulator (CREM)alpha is an ubiquitously expressed transcription factor and a counterpart of the activator CREB.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	39-43
17960953-9	2007	RESULTS: Assuming an HIT prevalence of 3%, relative to less costly strategies, ordering an antibody test and switching patients to argatroban if the result was positive (Test and Wait) had an ICER of $US163 396/QALY.	argatroban	131-141	cAMP responsive element modulator	Homo sapiens	192-196
17960953-10	2007	Pre-emptive switching to argatroban without antibody testing (No Test and Switch) was the most effective strategy but had an ICER of >$US1 million/QALY relative to the Test and Switch option.	argatroban	25-35	cAMP responsive element modulator	Homo sapiens	125-129
18047388-5	2007	In a modelled analysis based on results of the IDEAL trial, which showed significant reductions in cardiovascular endpoints with high-dose atorvastatin (80 mg/day) compared with conventional-dose simvastatin in patients with stable coronary heart disease, ICER values were below the commonly used cost-effectiveness threshold of euro50,000 per QALY gained in Norway, Sweden and Denmark, but were above this threshold in Finland (2005 values).	Atorvastatin	139-151	cAMP responsive element modulator	Homo sapiens	256-260
18047388-6	2007	A modelled US analysis that also included data from IDEAL and other sources showed an ICER of $US33,400 per QALY gained, assuming the incremental difference in acquisition cost between high-dose atorvastatin and conventional-dose simvastatin was $US1.40/day (2005 value).	Atorvastatin	195-207	cAMP responsive element modulator	Homo sapiens	86-90
18047388-6	2007	A modelled US analysis that also included data from IDEAL and other sources showed an ICER of $US33,400 per QALY gained, assuming the incremental difference in acquisition cost between high-dose atorvastatin and conventional-dose simvastatin was $US1.40/day (2005 value).	Simvastatin	230-241	cAMP responsive element modulator	Homo sapiens	86-90
18047388-10	2007	Another analysis conducted in the US used longer-term data and showed that high-dose atorvastatin versus conventional-dose statin was associated with an ICER of $US12,900 per QALY gained, assuming the daily difference in acquisition cost was $US1.40 (2005 value).	Atorvastatin	85-97	cAMP responsive element modulator	Homo sapiens	153-157
18047388-13	2007	Cost-effectiveness analyses based on major clinical trials comparing atorvastatin with placebo, usual medical care, simvastatin or pravastatin have generally shown that atorvastatin is associated with favourable ICER values, often well below commonly used cost-effectiveness thresholds.	Atorvastatin	169-181	cAMP responsive element modulator	Homo sapiens	212-216
16498408-4	2006	We demonstrate that the transcriptional repressor ICER, which is induced in a PKA-dependent manner by chronic hyperglycemia and cAMP-raising agents, is responsible for the decline of the four genes.	Cyclic AMP	128-132	cAMP responsive element modulator	Homo sapiens	50-54
17065415-0	2006	CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP.	Cyclic AMP	13-17	cAMP responsive element modulator	Homo sapiens	0-4
16357326-10	2006	PGE2 caused the expression of inducible cAMP early repressor (ICER) by a pathway involving PKA and ERK.	Dinoprostone	0-4	cAMP responsive element modulator	Homo sapiens	62-66
17065415-12	2006	CREM is needed to confer cAMP responsiveness in human StAR protein expression.	Cyclic AMP	25-29	cAMP responsive element modulator	Homo sapiens	0-4
16899718-0	2006	Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.	Amphetamine	89-100	cAMP responsive element modulator	Homo sapiens	13-43
16899718-4	2006	In the present study, we investigated the extent to which ICER is induced in the nucleus accumbens by two types of environmental stimuli, stress and amphetamine, and characterized how induction of ICER in this region affects complex behavior.	Amphetamine	149-160	cAMP responsive element modulator	Homo sapiens	58-62
16899718-5	2006	We show that stress and amphetamine each induces ICER expression and that overexpression of ICER in the nucleus accumbens, using viral-mediated gene transfer, increases behavioral responses to both rewarding and aversive emotional stimuli.	Amphetamine	24-35	cAMP responsive element modulator	Homo sapiens	49-53
16899718-5	2006	We show that stress and amphetamine each induces ICER expression and that overexpression of ICER in the nucleus accumbens, using viral-mediated gene transfer, increases behavioral responses to both rewarding and aversive emotional stimuli.	Amphetamine	24-35	cAMP responsive element modulator	Homo sapiens	92-96
16899718-6	2006	For example, ICER overexpression increases sensitivity to amphetamine-stimulated locomotor activity as well as to natural rewards such as sucrose and social grooming.	Amphetamine	58-69	cAMP responsive element modulator	Homo sapiens	13-17
16899718-6	2006	For example, ICER overexpression increases sensitivity to amphetamine-stimulated locomotor activity as well as to natural rewards such as sucrose and social grooming.	Sucrose	138-145	cAMP responsive element modulator	Homo sapiens	13-17
16357326-10	2006	PGE2 caused the expression of inducible cAMP early repressor (ICER) by a pathway involving PKA and ERK.	Dinoprostone	0-4	cAMP responsive element modulator	Homo sapiens	30-60
16498408-5	2006	ICER overexpression diminished the level of Granuphilin, Noc2, Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta-cells in response to secretagogues.	Cyclic AMP	94-98	cAMP responsive element modulator	Homo sapiens	0-4
16498408-6	2006	Moreover, the loss in the expression of the genes of the secretory machinery caused by glucose and cAMP-raising agents was prevented by an antisense construct that reduces ICER levels.	Glucose	87-94	cAMP responsive element modulator	Homo sapiens	172-176
16498408-6	2006	Moreover, the loss in the expression of the genes of the secretory machinery caused by glucose and cAMP-raising agents was prevented by an antisense construct that reduces ICER levels.	Cyclic AMP	99-103	cAMP responsive element modulator	Homo sapiens	172-176
16545208-22	2006	The ICER for PLDH compared with paclitaxel was pound 7033 per quality-adjusted life-year (QALY) in the overall patient population (comprising platinum-sensitive, -refractory and -resistant patients).	Platinum	142-150	cAMP responsive element modulator	Homo sapiens	4-8
16545208-23	2006	The ICER was more favourable in the platinum-sensitive group ( pound 5777 per QALY) and less favourable in the platinum-refractory/resistant group ( pound 9555 per QALY).	Platinum	36-44	cAMP responsive element modulator	Homo sapiens	4-8
16545208-23	2006	The ICER was more favourable in the platinum-sensitive group ( pound 5777 per QALY) and less favourable in the platinum-refractory/resistant group ( pound 9555 per QALY).	Platinum	111-119	cAMP responsive element modulator	Homo sapiens	4-8
16545208-25	2006	Incorporating the results of the additional trial data resulted in less favourable estimates for the ICER for PLDH versus paclitaxel compared with the base-case results.	Paclitaxel	122-132	cAMP responsive element modulator	Homo sapiens	101-105
16545208-26	2006	The ICER of PLDH compared with paclitaxel was pound 20,620 per QALY in the overall patient population, pound 16,183 per QALY in the platinum-sensitive population and pound 26,867 per QALY in the platinum-resistant and -refractory population.	Platinum	132-140	cAMP responsive element modulator	Homo sapiens	4-8
16545208-26	2006	The ICER of PLDH compared with paclitaxel was pound 20,620 per QALY in the overall patient population, pound 16,183 per QALY in the platinum-sensitive population and pound 26,867 per QALY in the platinum-resistant and -refractory population.	Platinum	195-203	cAMP responsive element modulator	Homo sapiens	4-8
16545208-34	2006	The ICER for paclitaxel-platinum combination therapy compared with CAP was pound 20,950 per QALY.	Paclitaxel	13-23	cAMP responsive element modulator	Homo sapiens	4-8
16545208-34	2006	The ICER for paclitaxel-platinum combination therapy compared with CAP was pound 20,950 per QALY.	Platinum	24-32	cAMP responsive element modulator	Homo sapiens	4-8
16545208-50	2006	Incorporating the results of additional trial data gave less favourable estimates for the ICER for PLDH versus paclitaxel monotherapy, compared with the base-case results.	Paclitaxel	111-121	cAMP responsive element modulator	Homo sapiens	90-94
16269517-11	2006	Chromatin immunoprecipitation assays demonstrate a replacement of CREB dimers bound to the inhibin alpha CRE by ICER dimers in ovarian granulosa cells in response to LH signaling.	Luteinizing Hormone	166-168	cAMP responsive element modulator	Homo sapiens	112-116
16556681-8	2006	These novel FSH regulated genes include transcription factors [cAMP responsive element modulator (CREM)/inducible cAMP early repressors (ICER), GATA 6, ZFN 361, Bcl11a, CITED1 and TCF 8] and other regulatory proteins and enzymes (IGF-BP3, syntaxin and PCK1) possibly important for oocyte/granulosa cell interaction and function.	Cyclic AMP	63-67	cAMP responsive element modulator	Homo sapiens	98-102
16451219-3	2006	Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter.	Colforsin	149-158	cAMP responsive element modulator	Homo sapiens	46-50
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Cyclic AMP	68-72	cAMP responsive element modulator	Homo sapiens	22-26
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Cyclic AMP	68-72	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Cyclic AMP	68-72	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Cyclic AMP	68-72	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Colforsin	82-91	cAMP responsive element modulator	Homo sapiens	22-26
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Colforsin	82-91	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Colforsin	82-91	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Colforsin	82-91	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Dinoprostone	96-112	cAMP responsive element modulator	Homo sapiens	22-26
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Dinoprostone	96-112	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Dinoprostone	96-112	cAMP responsive element modulator	Homo sapiens	54-58
16443828-5	2006	Ectopic expression of ICER or induction of endogenous ICER with the cAMP agonists forskolin and prostaglandin E2 resulted in the formation of ICER-containing complexes, including an ICER:CREB heterodimer to the AP-1/CRE-like site and inhibition of MIP-1beta promoter activity.	Dinoprostone	96-112	cAMP responsive element modulator	Homo sapiens	54-58
16443828-6	2006	Our data characterize an important binding site for the dominant-negative regulator ICER in the MIP-1beta promoter and suggest that dynamic changes in the relative levels of ICER and CREB play a crucial role in cAMP-mediated attenuation of MIP-1beta transcription in human T cells.	Cyclic AMP	211-215	cAMP responsive element modulator	Homo sapiens	84-88
16443828-6	2006	Our data characterize an important binding site for the dominant-negative regulator ICER in the MIP-1beta promoter and suggest that dynamic changes in the relative levels of ICER and CREB play a crucial role in cAMP-mediated attenuation of MIP-1beta transcription in human T cells.	Cyclic AMP	211-215	cAMP responsive element modulator	Homo sapiens	174-178
16451219-3	2006	Co-transfection of the inhibitory isoforms of CREM, ICER I and II and CREMbeta, and CRH promoter-luciferase constructs in 4B cells blunted basal and forskolin-stimulated CRH promoter activity, an effect which was abolished by mutation of the CRE of the CRH promoter.	Colforsin	149-158	cAMP responsive element modulator	Homo sapiens	52-56
16451219-4	2006	Western blot analyses and electromobility gel-shift and super-shift showed increases in endogenous ICER after 3 h of incubation with forskolin.	Colforsin	133-142	cAMP responsive element modulator	Homo sapiens	99-103
16451219-6	2006	The study shows that generation of ICER following prolonged stimulation with forskolin, or transfection of an ICER expression vector in hypothalamic cell lines expressing CRH, is associated with CREM binding to the CRH promoter and transcriptional repression.	Colforsin	77-86	cAMP responsive element modulator	Homo sapiens	35-39
16451219-6	2006	The study shows that generation of ICER following prolonged stimulation with forskolin, or transfection of an ICER expression vector in hypothalamic cell lines expressing CRH, is associated with CREM binding to the CRH promoter and transcriptional repression.	Colforsin	77-86	cAMP responsive element modulator	Homo sapiens	195-199
16605284-9	2006	RESULTS: The estimated ICER for losartan versus atenolol was 1337 Canadian dollars per QALY gained (1 Canadian dollar =0.75 US dollars, 2002 values).	Losartan	32-40	cAMP responsive element modulator	Homo sapiens	23-27
17129076-10	2006	In considering males for the base-case age at diagnosis, the ICER for etanercept versus methotrexate was $US85 100 per QALY.	Methotrexate	88-100	cAMP responsive element modulator	Homo sapiens	61-65
16605284-9	2006	RESULTS: The estimated ICER for losartan versus atenolol was 1337 Canadian dollars per QALY gained (1 Canadian dollar =0.75 US dollars, 2002 values).	Atenolol	48-56	cAMP responsive element modulator	Homo sapiens	23-27
16186489-2	2005	Recently, we found that expression of cAMP hydrolyzing phosphodiesterase 3A (PDE3A) was significantly reduced in human failing hearts, accompanied by up-regulation of inducible cAMP early repressor (ICER) expression.	Cyclic AMP	38-42	cAMP responsive element modulator	Homo sapiens	167-204
16103121-0	2005	The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.	Cyclic AMP	38-48	cAMP responsive element modulator	Homo sapiens	84-88
16103121-0	2005	The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.	Cyclic AMP	38-48	cAMP responsive element modulator	Homo sapiens	117-121
16103121-1	2005	The transcription factor cAMP-response element modulator (CREM) protein, plays a major role in cAMP-responsive gene regulation.	Cyclic AMP	25-29	cAMP responsive element modulator	Homo sapiens	58-62
16103121-4	2005	Furthermore we have recently reported that this change in the expression of CREM spliced variants is likely to have important ramifications on the regulation of downstream cAMP-response element-responsive target genes involved in uterine activity during gestation.	Cyclic AMP	172-176	cAMP responsive element modulator	Homo sapiens	76-80
16186489-3	2005	Angiotensin II (Ang II) and the beta-adrenergic receptor agonist isoproterenol (ISO) also induced persistent PDE3A down-regulation and concomitant ICER up-regulation in vitro, which is important in Ang II- and ISO-induced cardiomyocyte apoptosis.	Isoproterenol	65-78	cAMP responsive element modulator	Homo sapiens	147-151
16186489-3	2005	Angiotensin II (Ang II) and the beta-adrenergic receptor agonist isoproterenol (ISO) also induced persistent PDE3A down-regulation and concomitant ICER up-regulation in vitro, which is important in Ang II- and ISO-induced cardiomyocyte apoptosis.	Isoproterenol	80-83	cAMP responsive element modulator	Homo sapiens	147-151
16186489-6	2005	PDE3A down-regulation activated cAMP/PKA signaling, leading to ICER up-regulation via PKA-dependent stabilization of ICER.	Cyclic AMP	32-36	cAMP responsive element modulator	Homo sapiens	63-67
16186489-6	2005	PDE3A down-regulation activated cAMP/PKA signaling, leading to ICER up-regulation via PKA-dependent stabilization of ICER.	Cyclic AMP	32-36	cAMP responsive element modulator	Homo sapiens	117-121
15744818-0	2005	Rolipram, a phosphodiesterase 4 inhibitor, stimulates inducible cAMP early repressor expression in osteoblasts.	Rolipram	0-8	cAMP responsive element modulator	Homo sapiens	54-84
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element modulator	Homo sapiens	213-217
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element modulator	Homo sapiens	219-249
16217122-7	2005	By molecular crosstalk, those different inputs on pinealocytes seem to fine-tune the shape of the melatonin signal, by interacting at various levels with the NE/cAMP/pCREB/ICER pathway.	Melatonin	98-107	cAMP responsive element modulator	Homo sapiens	172-176
16059773-1	2005	CREM, the cyclic adenosine monophosphate (cAMP) responsive element modulator, belongs to a multigene family of cAMP-responsive transcription factors.	Cyclic AMP	42-46	cAMP responsive element modulator	Homo sapiens	0-4
15744818-4	2005	The induction of ICER mRNA expression by rolipram was suppressed by the inhibitors of protein kinase A (PKA) and p38 MAPK, suggesting the involvement of PKA and p38 MAPK activation in ICER expression by rolipram.	Rolipram	41-49	cAMP responsive element modulator	Homo sapiens	17-21
15744818-4	2005	The induction of ICER mRNA expression by rolipram was suppressed by the inhibitors of protein kinase A (PKA) and p38 MAPK, suggesting the involvement of PKA and p38 MAPK activation in ICER expression by rolipram.	Rolipram	41-49	cAMP responsive element modulator	Homo sapiens	184-188
15691874-1	2005	cAMP-response element (CRE) binding (CREB) and modulator (CREM) proteins, activated by protein kinase A-mediated phosphorylation, bind as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	58-62
15782814-5	2005	Simultaneously, adrenergically-induced expression of inducible cAMP early repressor (ICER) negatively regulates aa-nat gene expression and controls the amplitude of melatonin rhythm.	Melatonin	165-174	cAMP responsive element modulator	Homo sapiens	53-83
15782814-5	2005	Simultaneously, adrenergically-induced expression of inducible cAMP early repressor (ICER) negatively regulates aa-nat gene expression and controls the amplitude of melatonin rhythm.	Melatonin	165-174	cAMP responsive element modulator	Homo sapiens	85-89
15701933-13	2004	The research found a median bootstrap ICER estimate of pound sterling 224 From the cost-effectiveness acceptability curve (CEAC) it was found that 89.6% of the cost-effectiveness plane represented a cost saving over the control intervention while 99.9% represented an improvement in effect.	ceac	123-127	cAMP responsive element modulator	Homo sapiens	38-42
15960556-5	2005	RESULTS: The primary analysis suggested that infliximab plus MTX had an ICER of 33,618 pounds per QALY gained.	Methotrexate	61-64	cAMP responsive element modulator	Homo sapiens	72-76
15695103-11	2005	Moreover, from coimmunoprecipitation experiments, this increase in CBP expression would be expected to facilitate the transactivation potential of the cyclic adenosine monophosphate (cAMP)-dependent transcription factors CREB, CREM, and ATF-2.	Cyclic AMP	151-181	cAMP responsive element modulator	Homo sapiens	227-231
15695103-11	2005	Moreover, from coimmunoprecipitation experiments, this increase in CBP expression would be expected to facilitate the transactivation potential of the cyclic adenosine monophosphate (cAMP)-dependent transcription factors CREB, CREM, and ATF-2.	Cyclic AMP	183-187	cAMP responsive element modulator	Homo sapiens	227-231
15474076-1	2004	OBJECTIVE: To evaluate whether defective cyclic adenosine monophosphate responsive element modulator (CREM) expression is the causative factor of spermatid maturation arrest (SMA).	Cyclic AMP	41-71	cAMP responsive element modulator	Homo sapiens	102-106
15384069-1	2004	In morphogenetic dynamics of neurons, and in adaptive physiology of brain function, transcription factors of the cyclicAMP signaling pathway, such as activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role.	Cyclic AMP	113-122	cAMP responsive element modulator	Homo sapiens	226-261
15384069-1	2004	In morphogenetic dynamics of neurons, and in adaptive physiology of brain function, transcription factors of the cyclicAMP signaling pathway, such as activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role.	Cyclic AMP	113-122	cAMP responsive element modulator	Homo sapiens	263-267
15031457-8	2004	RESULTS: Aspirin, a low-cost intervention applicable to a large number of stroke patients (9153 first-ever cases), resulted in modest health benefits (946 DALYs saved) and a mean ICER (based on incidence costs) of US 1421 dollars per DALY saved.	Aspirin	9-16	cAMP responsive element modulator	Homo sapiens	179-183
15232059-7	2004	A compelling amount of data has established that cAMP-response-element modulator (CREM), a transcription factor responsive to the cAMP signal transduction pathway, drives expression of key testis-specific genes.	Cyclic AMP	49-53	cAMP responsive element modulator	Homo sapiens	82-86
15302588-4	2004	We show that a subset of cAMP response element (CRE) binding proteins of the CREM type shuttles within a biologically meaningful time frame, revealing a continuous flow into the cytoplasm that persists during signaling.	Cyclic AMP	25-29	cAMP responsive element modulator	Homo sapiens	77-81
15170357-9	2004	cAMP response element binding and modulator transcription factors (CREB and CREM), typical target proteins of PKA, were expressed in A673 cells, as was the coactivator CREB binding protein (CBP).	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	76-80
14512522-3	2003	In somatic cells activation by CREM requires its phosphorylation at a unique regulatory site (Ser117) and subsequent interaction with the ubiquitous coactivator CBP (cAMP response element binding protein-binding protein).	Cyclic AMP	166-170	cAMP responsive element modulator	Homo sapiens	31-35
12805292-2	2003	Several members of the CREM/ICER (cAMP responsive element modulator/inducible cAMP early repressor) protein family may act as endogenous CREB antagonists.	Cyclic AMP	78-82	cAMP responsive element modulator	Homo sapiens	23-32
12855670-0	2003	ICER-capades: putting cardiac cyclic AMP signaling "on ice".	Adenosine Monophosphate	37-40	cAMP responsive element modulator	Homo sapiens	0-4
12805292-2	2003	Several members of the CREM/ICER (cAMP responsive element modulator/inducible cAMP early repressor) protein family may act as endogenous CREB antagonists.	Cyclic AMP	34-38	cAMP responsive element modulator	Homo sapiens	23-32
12554693-2	2003	CREM mRNA is robustly expressed in human myocardium, and identified isoforms may suppress cAMP response element-mediated transcription.	Cyclic AMP	90-94	cAMP responsive element modulator	Homo sapiens	0-4
12609974-9	2003	Consistent with this finding, IFN-gamma stimulated CK2 activity and the level of phosphorylated cAMP response element-binding protein, which is known to induce ICER gene transcription, and this response was inhibited in the presence of apigenin.	Cyclic AMP	96-100	cAMP responsive element modulator	Homo sapiens	160-164
12609974-10	2003	These studies, therefore, identify a previously uncharacterized pathway, involving the IFN-gamma-mediated stimulation of CK2 activity, activation of cAMP response element-binding protein, and increased production of ICER, which may then play an important role in the inhibition of macrophage gene transcription by this cytokine.	Cyclic AMP	149-153	cAMP responsive element modulator	Homo sapiens	216-220
12626549-5	2003	In addition, as assessed by chromatin immunoprecipitation experiments, antisense CREM prevented the binding of protein 300 and cAMP response element binding protein and promoted the acetylation of histones.	Cyclic AMP	127-131	cAMP responsive element modulator	Homo sapiens	81-85
12626549-8	2003	CREM, in turn, binds protein 300 and cAMP response element binding protein, but CREM is unable to activate its histone acetyltransferase activity, which results in condensation of chromatin and down-regulation of IL-2 production.	Cyclic AMP	37-41	cAMP responsive element modulator	Homo sapiens	0-4
12621361-7	2003	In particular, several events including the low expression of mutant Gs, the induction of phosphodiesterases, that are involved in cAMP degradation, and of the inducible cAMP early repressor (ICER) that represses cAMP induced gene expression, together with a high sensitivity to somatostatin have been characterized in gsp positive tumors.	Cyclic AMP	170-174	cAMP responsive element modulator	Homo sapiens	192-196
12555239-6	2003	Association analysis in an extended sample of German patients (n = 88) revealed a significant excess of the shorter CREM P 2 promoter eight-repeat trinucleotide allele and of genotypes containing the eight-repeat trinucleotide allele in panic disorder (P = 0.02), in particular in panic disorder without agoraphobia (P = 0.001).	trinucleotide	147-160	cAMP responsive element modulator	Homo sapiens	116-120
12637127-11	2003	The ICER for ipratropium over placebo was $273.03; for formoterol 12 microg over ipratropium, $1611.32.	Ipratropium	13-24	cAMP responsive element modulator	Homo sapiens	4-8
12637127-14	2003	The ICER for formoterol 12 microg over placebo was $34.51 per QOL score point.	Formoterol Fumarate	13-23	cAMP responsive element modulator	Homo sapiens	4-8
11701720-2	2001	Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB).	Cyclic AMP	58-62	cAMP responsive element modulator	Homo sapiens	236-269
12218128-10	2002	EMSAs indicate that an activating transcription factor/cAMP response element binding protein/cAMP response element modulator family member, but not phosphorylated cAMP response element binding protein-1, binds to ARE-2.	Cyclic AMP	55-59	cAMP responsive element modulator	Homo sapiens	93-124
12111546-4	2002	Recent work shows how photoperiod, through the hormone melatonin, affects the timing and amplitude of expression of the Per1 gene, as well as other genes such as Icer.	Melatonin	55-64	cAMP responsive element modulator	Homo sapiens	162-166
12530696-7	2002	At the nuclear level, the cAMP pathway regulates transcription mainly by PKA-dependent phosphorylation of the cyclic AMP response element binding (CREB) family of transcription factors (CREB, CREM, and ATF-1).	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	192-196
12530696-7	2002	At the nuclear level, the cAMP pathway regulates transcription mainly by PKA-dependent phosphorylation of the cyclic AMP response element binding (CREB) family of transcription factors (CREB, CREM, and ATF-1).	Cyclic AMP	110-120	cAMP responsive element modulator	Homo sapiens	192-196
12397208-0	2002	Novel leader exons of the cyclic adenosine 3",5"-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates.	Cyclic AMP	26-62	cAMP responsive element modulator	Homo sapiens	91-95
12119268-8	2002	The CREM isoform ICER is stimulated by cAMP, and its expression is increased in Gsp-harboring tumors.	Cyclic AMP	39-43	cAMP responsive element modulator	Homo sapiens	4-8
12119268-8	2002	The CREM isoform ICER is stimulated by cAMP, and its expression is increased in Gsp-harboring tumors.	Cyclic AMP	39-43	cAMP responsive element modulator	Homo sapiens	17-21
11754361-4	2002	ICER is inducible in human peripheral blood CD3(+) T cells, but in CD19(+) B cells, its induction is less responsive to forskolin treatment.	Colforsin	120-129	cAMP responsive element modulator	Homo sapiens	0-4
11781283-7	2002	Aspirin prevents 2952 colorectal cancers and saves 5301 life-years at an ICER of $47,249 per life-year saved compared with no intervention.	Aspirin	0-7	cAMP responsive element modulator	Homo sapiens	73-77
11781283-9	2002	Varying the annual aspirin-related costs between $50 and $200 results in ICER changes between $4617 and $57,080, with the 2 strategies breaking even at $70.	Aspirin	19-26	cAMP responsive element modulator	Homo sapiens	73-77
11781283-10	2002	Applying aspirin chemoprevention plus colonoscopy screening concomitantly yields an ICER of $227,607 per life-year saved compared with screening colonoscopy alone.	Aspirin	9-16	cAMP responsive element modulator	Homo sapiens	84-88
11701720-2	2001	Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB).	Cyclic AMP	58-62	cAMP responsive element modulator	Homo sapiens	271-275
11701720-2	2001	Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB).	Steroids	126-133	cAMP responsive element modulator	Homo sapiens	236-269
11701720-2	2001	Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB).	Cyclic AMP	199-203	cAMP responsive element modulator	Homo sapiens	236-269
11701720-2	2001	Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB).	Cyclic AMP	199-203	cAMP responsive element modulator	Homo sapiens	271-275
11701720-5	2001	On the other hand, mRNA for the inducible cAMP early repressor isoforms, which derive from an internal promoter of CREM gene, was detected in the normal adrenal and in seven of eight adenomas, but in only three of eight carcinomas.	Cyclic AMP	42-46	cAMP responsive element modulator	Homo sapiens	115-119
11466319-1	2001	Inducible cAMP early repressor (ICER) is an important mediator of cAMP antiproliferative activity that acts as a putative tumor suppressor gene product.	Cyclic AMP	10-14	cAMP responsive element modulator	Homo sapiens	32-36
11466319-3	2001	We found that cAMP stabilized ICER protein by inhibiting the mitogen-activated protein kinase (MAPK) cascade.	Cyclic AMP	14-18	cAMP responsive element modulator	Homo sapiens	30-34
11466319-5	2001	ICER phosphorylation was abrogated by inhibition of the MAPK pathway either by cAMP or directly by the MAPK inhibitor PD098059.	Cyclic AMP	79-83	cAMP responsive element modulator	Homo sapiens	0-4
11466319-5	2001	ICER phosphorylation was abrogated by inhibition of the MAPK pathway either by cAMP or directly by the MAPK inhibitor PD098059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	118-126	cAMP responsive element modulator	Homo sapiens	0-4
11466319-6	2001	The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41).	Serine	142-148	cAMP responsive element modulator	Homo sapiens	82-86
11466319-6	2001	The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41).	Serine	142-148	cAMP responsive element modulator	Homo sapiens	123-127
11466319-6	2001	The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41).	Serine	158-161	cAMP responsive element modulator	Homo sapiens	82-86
11466319-6	2001	The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41).	Serine	158-161	cAMP responsive element modulator	Homo sapiens	123-127
11466319-8	2001	This alteration in stability was due to the inability of the Ser-41-mutant ICER to be efficiently ubiquitinated and degraded via the ubiquitin-proteasome pathway.	Serine	61-64	cAMP responsive element modulator	Homo sapiens	75-79
11488943-5	2001	The increasing amount in ICER protein leads ultimately to the termination of mRNA accumulation of cAMP-inducible genes, including the gene for the Aa-nat that controls melatonin production.	Cyclic AMP	98-102	cAMP responsive element modulator	Homo sapiens	25-29
11507053-0	2001	The expression of inducible cAMP early repressor (ICER) is altered in prostate cancer cells and reverses the transformed phenotype of the LNCaP prostate tumor cell line.	Cyclic AMP	28-32	cAMP responsive element modulator	Homo sapiens	50-54
11507053-4	2001	Forced expression of ICER in LNCaP cells caused inhibition of cell growth and thymidine incorporation and halted cells at the G(1) phase of the cell cycle.	Thymidine	78-87	cAMP responsive element modulator	Homo sapiens	21-25
11526370-7	2001	This yields incremental cost-effectiveness ratios (ICERs) for metoprolol relative to conventional therapy alone of $4,140 per life-year gained, and for carvedilol relative to metoprolol, the ICER is $8,394 per life-year gained.	Metoprolol	62-72	cAMP responsive element modulator	Homo sapiens	51-55
11506377-3	2001	In rodents, the cyclic AMP-mediated, temporally sequential up-regulation of two transcription factors, the activator CREB (cyclic AMP-responsive element-binding protein) and the inhibitor ICER (inducible cyclic AMP-dependent early repressor), is the core mechanism to determine rhythmic accumulation of the mRNA encoding for the rate-limiting enzyme in melatonin synthesis, the arylalkylamine N-acetyltransferase (AA-NAT).	Cyclic AMP	16-26	cAMP responsive element modulator	Homo sapiens	188-192
11506377-3	2001	In rodents, the cyclic AMP-mediated, temporally sequential up-regulation of two transcription factors, the activator CREB (cyclic AMP-responsive element-binding protein) and the inhibitor ICER (inducible cyclic AMP-dependent early repressor), is the core mechanism to determine rhythmic accumulation of the mRNA encoding for the rate-limiting enzyme in melatonin synthesis, the arylalkylamine N-acetyltransferase (AA-NAT).	Cyclic AMP	16-26	cAMP responsive element modulator	Homo sapiens	194-240
11506377-3	2001	In rodents, the cyclic AMP-mediated, temporally sequential up-regulation of two transcription factors, the activator CREB (cyclic AMP-responsive element-binding protein) and the inhibitor ICER (inducible cyclic AMP-dependent early repressor), is the core mechanism to determine rhythmic accumulation of the mRNA encoding for the rate-limiting enzyme in melatonin synthesis, the arylalkylamine N-acetyltransferase (AA-NAT).	Melatonin	353-362	cAMP responsive element modulator	Homo sapiens	194-240
11488943-5	2001	The increasing amount in ICER protein leads ultimately to the termination of mRNA accumulation of cAMP-inducible genes, including the gene for the Aa-nat that controls melatonin production.	Melatonin	168-177	cAMP responsive element modulator	Homo sapiens	25-29
11380701-1	2001	CREM is a cAMP-related transcription factor and alternate promotor usage and splicing generate repressor and activator transcripts of CREM within the testis.	Cyclic AMP	10-14	cAMP responsive element modulator	Homo sapiens	0-4
11380701-1	2001	CREM is a cAMP-related transcription factor and alternate promotor usage and splicing generate repressor and activator transcripts of CREM within the testis.	Cyclic AMP	10-14	cAMP responsive element modulator	Homo sapiens	134-138
11344215-6	2001	Moreover, no positive correlation between the levels of CREB and ICER transcripts was observed, suggesting the possible presence of alterations in the mechanisms by which cAMP signaling directs the expression of CREB and/or ICER genes.	Cyclic AMP	171-175	cAMP responsive element modulator	Homo sapiens	224-228
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	66-70
11274533-5	2001	However, double-contrast barium enema examination screening every 3 years plus annual fecal occult blood testing had an ICER of more than $100,000 per life-year saved.	Barium	25-31	cAMP responsive element modulator	Homo sapiens	120-124
11238674-3	2001	Nuclear extracts from stimulated normal T cells display increased binding of phosphorylated cAMP-responsive element binding protein (p-CREB) to the -180 site of the IL-2 promoter, whereas nuclear extracts from stimulated SLE T cells display primarily p-CREM and decreased p-CREB binding.	Cyclic AMP	92-96	cAMP responsive element modulator	Homo sapiens	253-257
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	76-80	cAMP responsive element modulator	Homo sapiens	211-241
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	76-80	cAMP responsive element modulator	Homo sapiens	243-247
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	76-80	cAMP responsive element modulator	Homo sapiens	292-325
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	131-135	cAMP responsive element modulator	Homo sapiens	211-241
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	131-135	cAMP responsive element modulator	Homo sapiens	243-247
11344215-3	2001	We focused on 2 nuclear transcription factors that are final targets of the cAMP-dependent pathway and are positively regulated by cAMP signaling, i.e. the cAMP-responsive element binding protein (CREB) and the inducible cAMP early repressor (ICER), that derives from alternative splicing of cAMP-responsive element modulator gene.	Cyclic AMP	131-135	cAMP responsive element modulator	Homo sapiens	292-325
11274533-4	2001	In average-risk individuals, screening with double-contrast barium enema examination every 3 years, or every 5 years with annual fecal occult blood testing, had an ICER of less than $55,600 per life-year saved.	Barium	60-66	cAMP responsive element modulator	Homo sapiens	164-168
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	72-100
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	137-141
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	76-89	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	91-105	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	143-156	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	143-156	cAMP responsive element modulator	Homo sapiens	40-44
11002260-0	2000	Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear cells.	Cyclic AMP	88-92	cAMP responsive element modulator	Homo sapiens	110-114
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Hydrogen	59-67	cAMP responsive element modulator	Homo sapiens	181-185
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Tyrosine	103-106	cAMP responsive element modulator	Homo sapiens	181-185
10952992-4	2000	Critical to family selective dimerization are intersubunit hydrogen bonds between basic region residue Tyr(307) and leucine zipper residue Glu(312), which are conserved in all CREB/CREM/ATF-1 family members.	Glutamic Acid	139-142	cAMP responsive element modulator	Homo sapiens	181-185
11094064-2	2000	Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for cyclic AMP-dependent derepression of the prodynorphin gene in human neuroblastoma cells.	Cyclic AMP	179-189	cAMP responsive element modulator	Homo sapiens	78-82
11050006-8	2000	CKLiK kinase activity was dependent on Ca(++) and calmodulin as analyzed by in vitro phosphorylation of cyclic adenosine monophosphate responsive element modulator (CREM).	Cyclic AMP	104-134	cAMP responsive element modulator	Homo sapiens	165-169
11079452-2	2000	The cAMP-dependent transcription factor CREM directs in the testis the expression of genes related to the structuring of mature spermatozoa.	Cyclic AMP	4-8	cAMP responsive element modulator	Homo sapiens	40-44
11002260-5	2000	Other less studied family members include the inducible cAMP early repressor (ICER) proteins.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	78-82
11108130-1	2000	The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway.	Cyclic AMP	82-86	cAMP responsive element modulator	Homo sapiens	9-13
10857848-3	2000	It is important that the CD28-responsive element (CD28RE), a composite DNA binding element consisting of NFAT and cyclic AMP-responsive (CRE)-like motifs in position of -160 of IL-2 promoter has the high affinity for ICER binding as well as NFAT/ICER complex formation.	cd28re	50-56	cAMP responsive element modulator	Homo sapiens	217-221
10871653-0	2000	Expression of the cyclic AMP-dependent transcription factors, CREB, CREM and ATF2, in the human myometrium during pregnancy and labour.	Cyclic AMP	18-28	cAMP responsive element modulator	Homo sapiens	68-72
10857848-3	2000	It is important that the CD28-responsive element (CD28RE), a composite DNA binding element consisting of NFAT and cyclic AMP-responsive (CRE)-like motifs in position of -160 of IL-2 promoter has the high affinity for ICER binding as well as NFAT/ICER complex formation.	cd28re	50-56	cAMP responsive element modulator	Homo sapiens	246-250
10857848-3	2000	It is important that the CD28-responsive element (CD28RE), a composite DNA binding element consisting of NFAT and cyclic AMP-responsive (CRE)-like motifs in position of -160 of IL-2 promoter has the high affinity for ICER binding as well as NFAT/ICER complex formation.	Cyclic AMP	114-124	cAMP responsive element modulator	Homo sapiens	217-221
10857848-3	2000	It is important that the CD28-responsive element (CD28RE), a composite DNA binding element consisting of NFAT and cyclic AMP-responsive (CRE)-like motifs in position of -160 of IL-2 promoter has the high affinity for ICER binding as well as NFAT/ICER complex formation.	Cyclic AMP	114-124	cAMP responsive element modulator	Homo sapiens	246-250
10857848-5	2000	Because ICER does not possess a transactivation domain required for the recruitment of CBP/p300, the binding of ICER to CD28RE and/or composite motifs containing CRE-like DNA motifs may lead to uncoupling of CBP/p300 thus extinguishing IL-2 expression as well as expression of numerous other cytokines and chemokines.	cd28re	120-126	cAMP responsive element modulator	Homo sapiens	112-116
10752062-6	2000	The molecular mechanisms involved in rhythmic synthesis of melatonin involve the CREM gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway.	Melatonin	59-68	cAMP responsive element modulator	Homo sapiens	81-85
10634409-13	2000	H295R demonstrates that CREMtau up-regulation can compensate for CREB deficiency to maintain CRE regulation by cAMP and is a model of compensation mechanisms between the members of the CREB/ CREM/ATF-1 family of transcription factors.	Cyclic AMP	111-115	cAMP responsive element modulator	Homo sapiens	24-28
10752062-6	2000	The molecular mechanisms involved in rhythmic synthesis of melatonin involve the CREM gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway.	Cyclic AMP	160-164	cAMP responsive element modulator	Homo sapiens	81-85
10752062-7	2000	The CREM product, ICER, is rhythmically expressed and participates in a transcriptional autoregulatory loop which also controls the amplitude of oscillations of serotonin N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis.	Melatonin	221-230	cAMP responsive element modulator	Homo sapiens	4-8
10752062-7	2000	The CREM product, ICER, is rhythmically expressed and participates in a transcriptional autoregulatory loop which also controls the amplitude of oscillations of serotonin N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis.	Melatonin	221-230	cAMP responsive element modulator	Homo sapiens	18-22
10697414-1	2000	In eukaryotes, transcriptional regulation on stimulation of the adenylate cyclase signaling pathway is mediated by a family of cyclic AMP-responsive nuclear factors, including CREB, CREM, and ATF-1.	Cyclic AMP	127-137	cAMP responsive element modulator	Homo sapiens	182-186
10409662-1	1999	We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs).	Cyclic AMP	83-93	cAMP responsive element modulator	Homo sapiens	122-126
10586058-4	1999	In the present study, we demonstrate that cAMP response element-binding protein/cAMP response element modulator (CREB/CREM), activating transcription factor-2/c-Jun, and Jun-Jun/Oct complexes bind to this site.	Cyclic AMP	42-46	cAMP responsive element modulator	Homo sapiens	80-111
10586058-4	1999	In the present study, we demonstrate that cAMP response element-binding protein/cAMP response element modulator (CREB/CREM), activating transcription factor-2/c-Jun, and Jun-Jun/Oct complexes bind to this site.	Cyclic AMP	42-46	cAMP responsive element modulator	Homo sapiens	118-122
10591614-2	1999	The TNP1 gene-encoding TP1 (transition protein 1) protein contains a cAMP-responsive element (CRE) that serves as binding site for the CRE modulator (CREM).	Cyclic AMP	69-73	cAMP responsive element modulator	Homo sapiens	135-148
10591614-2	1999	The TNP1 gene-encoding TP1 (transition protein 1) protein contains a cAMP-responsive element (CRE) that serves as binding site for the CRE modulator (CREM).	Cyclic AMP	69-73	cAMP responsive element modulator	Homo sapiens	150-154
10449798-5	1999	This study reveals how the duration of photoperiodic time, conveyed through melatonin, is decoded as amplitude of Per1 and ICER (inducible cAMP early repressor) gene expression in the PT.	Melatonin	76-85	cAMP responsive element modulator	Homo sapiens	123-127
10449798-5	1999	This study reveals how the duration of photoperiodic time, conveyed through melatonin, is decoded as amplitude of Per1 and ICER (inducible cAMP early repressor) gene expression in the PT.	Melatonin	76-85	cAMP responsive element modulator	Homo sapiens	129-159
10409662-1	1999	We analyzed a mechanism of transcriptional regulation of the human insulin gene by cyclic AMP response element modulator (CREM) through four cyclic AMP response elements (CREs).	Cyclic AMP	141-151	cAMP responsive element modulator	Homo sapiens	122-126
10373550-4	1999	Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	116-120
10390618-1	1999	The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinases stimulated by cyclic AMP, Ca2+, growth factors and stress signals.	Serine	82-88	cAMP responsive element modulator	Homo sapiens	13-17
10373550-4	1999	Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIgamma, a product of the CREM gene, and hATF5, a novel ATF homolog.	Cyclic AMP	44-54	cAMP responsive element modulator	Homo sapiens	116-120
10390618-1	1999	The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinases stimulated by cyclic AMP, Ca2+, growth factors and stress signals.	Cyclic AMP	122-132	cAMP responsive element modulator	Homo sapiens	13-17
9545284-0	1998	Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes.	Cyclic AMP	42-52	cAMP responsive element modulator	Homo sapiens	34-38
10636469-2	1999	Candidate transcription factors regulating the proenkephalin gene in opposite directions are cAMP-response-element-binding protein (CREB) (when phosphorylated, a positive regulator) and cAMP-responsive modulatory inducible cAMP early repressor (CREM/ICER) (a negative regulator).	Cyclic AMP	186-190	cAMP responsive element modulator	Homo sapiens	245-249
10636469-2	1999	Candidate transcription factors regulating the proenkephalin gene in opposite directions are cAMP-response-element-binding protein (CREB) (when phosphorylated, a positive regulator) and cAMP-responsive modulatory inducible cAMP early repressor (CREM/ICER) (a negative regulator).	Cyclic AMP	186-190	cAMP responsive element modulator	Homo sapiens	250-254
10636469-4	1999	Cotransfection of ICER with ENK-CAT12 into primary hypothalamic cultures produced a decrease in chloramphenicol acetyl transferase (CAT) levels following cAMP or LPS stimulation.	Cyclic AMP	154-158	cAMP responsive element modulator	Homo sapiens	18-22
10636469-5	1999	PhosphoCREB is downregulated and CREM/ICER is upregulated in the PVN by muscimol, suggesting that the regulation of these transcription factors may underlie the inhibitory effect of muscimol on target genes in the PVN.	Muscimol	72-80	cAMP responsive element modulator	Homo sapiens	33-37
10636469-5	1999	PhosphoCREB is downregulated and CREM/ICER is upregulated in the PVN by muscimol, suggesting that the regulation of these transcription factors may underlie the inhibitory effect of muscimol on target genes in the PVN.	Muscimol	72-80	cAMP responsive element modulator	Homo sapiens	38-42
10636469-5	1999	PhosphoCREB is downregulated and CREM/ICER is upregulated in the PVN by muscimol, suggesting that the regulation of these transcription factors may underlie the inhibitory effect of muscimol on target genes in the PVN.	Muscimol	182-190	cAMP responsive element modulator	Homo sapiens	33-37
10636469-5	1999	PhosphoCREB is downregulated and CREM/ICER is upregulated in the PVN by muscimol, suggesting that the regulation of these transcription factors may underlie the inhibitory effect of muscimol on target genes in the PVN.	Muscimol	182-190	cAMP responsive element modulator	Homo sapiens	38-42
9768690-5	1998	The expressions of the cAMP-responsive element-binding protein and CREM genes create different isoforms, which can be divided into two groups: activators or repressors of gene regulation.	Cyclic AMP	23-27	cAMP responsive element modulator	Homo sapiens	67-71
9826119-11	1998	Finally, recent evidence suggests that cAMP-dependent transcription mechanisms may play a role during beta-adrenergic stimulation and cardiomyopathy with heart failure - by means of altered actions of cAMP response element binding protein, the cAMP response element modulator, or the activating transcription factor 1.	Cyclic AMP	39-43	cAMP responsive element modulator	Homo sapiens	244-275
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	74-80	cAMP responsive element modulator	Homo sapiens	39-43
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	74-80	cAMP responsive element modulator	Homo sapiens	147-151
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	119-122	cAMP responsive element modulator	Homo sapiens	39-43
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	119-122	cAMP responsive element modulator	Homo sapiens	147-151
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	136-139	cAMP responsive element modulator	Homo sapiens	39-43
10086359-1	1999	Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP.	Serine	136-139	cAMP responsive element modulator	Homo sapiens	147-151
10086359-6	1999	As ACT bypasses the classical requirements for activation, namely phosphorylation of Ser 117 and interaction with CBP, it represents a new route for transcriptional activation by CREM and CREB.	Serine	85-88	cAMP responsive element modulator	Homo sapiens	179-183
9737722-2	1998	The cAMP response element modulator (CREM) regulates the transcription of cAMP-responsive genes and might be involved in the regulation of cardiac gene expression.	Cyclic AMP	4-8	cAMP responsive element modulator	Homo sapiens	37-41
9545284-2	1998	Here we report that cAMP-mediated attenuation of the transcription of T helper-1-specific cytokine genes in human medullary thymocytes correlates with the induction of the cAMP-mediated transcriptional repressor ICER (inducible cAMP early repressor).	Cyclic AMP	20-24	cAMP responsive element modulator	Homo sapiens	212-216
9545284-2	1998	Here we report that cAMP-mediated attenuation of the transcription of T helper-1-specific cytokine genes in human medullary thymocytes correlates with the induction of the cAMP-mediated transcriptional repressor ICER (inducible cAMP early repressor).	Cyclic AMP	20-24	cAMP responsive element modulator	Homo sapiens	218-248
9545284-2	1998	Here we report that cAMP-mediated attenuation of the transcription of T helper-1-specific cytokine genes in human medullary thymocytes correlates with the induction of the cAMP-mediated transcriptional repressor ICER (inducible cAMP early repressor).	Cyclic AMP	172-176	cAMP responsive element modulator	Homo sapiens	212-216
9545284-2	1998	Here we report that cAMP-mediated attenuation of the transcription of T helper-1-specific cytokine genes in human medullary thymocytes correlates with the induction of the cAMP-mediated transcriptional repressor ICER (inducible cAMP early repressor).	Cyclic AMP	172-176	cAMP responsive element modulator	Homo sapiens	218-248
9545284-5	1998	In extracts prepared from human medullary thymocytes treated with forskolin and ionomycin, these composite sites bind endogenously expressed ICER either singly or in complexes.	Colforsin	66-75	cAMP responsive element modulator	Homo sapiens	141-145
9545284-5	1998	In extracts prepared from human medullary thymocytes treated with forskolin and ionomycin, these composite sites bind endogenously expressed ICER either singly or in complexes.	Ionomycin	80-89	cAMP responsive element modulator	Homo sapiens	141-145
9545284-6	1998	Moreover, in Jurkat cells, ectopically expressed ICER represses transcription from NFAT-mediated, phorbol ester/ionophore-activated IL-2, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha promoters.	Phorbol Esters	98-111	cAMP responsive element modulator	Homo sapiens	49-53
9510006-1	1998	Mice lacking the functional cAMP responsive element modulator (CREM) gene, a component of cAMP-mediated signal transduction, exhibit a specific arrest of round spermatid development although follicle stimulating hormone (FSH) and androgen secretion are not impaired.	Cyclic AMP	28-32	cAMP responsive element modulator	Homo sapiens	63-67
9510963-7	1998	2) The testis-specific cAMP response element modulator (CREM) transcription factor binds a cAMP response element (CRE)-like sequence located at position -433.	Cyclic AMP	23-27	cAMP responsive element modulator	Homo sapiens	56-60
9531892-2	1998	DESIGN: Standard immunohistochemical staining using a rabbit polyclonal antibody against the tau isoform of the cAMP responsive element modulator protein was performed on 5-microM sections of Bouin"s fixed, paraffin-embedded testicular tissue obtained from azoospermic or severely oligozoospermic men for routine clinical purposes.	Paraffin	207-215	cAMP responsive element modulator	Homo sapiens	112-145
9531892-6	1998	INTERVENTION(S): Rabbit polyclonal cAMP responsive element modulator tau antibody was applied to the paraffin-embedded testis sections.	Paraffin	101-109	cAMP responsive element modulator	Homo sapiens	35-68
9395245-7	1997	Importantly, induction by NGF occurs via a subset of the CREs present in the ICER promoter which were previously shown to direct cAMP-inducibility.	Cyclic AMP	129-133	cAMP responsive element modulator	Homo sapiens	77-81
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Colforsin	16-25	cAMP responsive element modulator	Homo sapiens	103-107
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Colforsin	16-25	cAMP responsive element modulator	Homo sapiens	117-121
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Colforsin	16-25	cAMP responsive element modulator	Homo sapiens	123-159
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Glutamic Acid	29-38	cAMP responsive element modulator	Homo sapiens	103-107
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Glutamic Acid	29-38	cAMP responsive element modulator	Homo sapiens	117-121
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Glutamic Acid	29-38	cAMP responsive element modulator	Homo sapiens	123-159
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Cyclic AMP	186-190	cAMP responsive element modulator	Homo sapiens	103-107
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Cyclic AMP	186-190	cAMP responsive element modulator	Homo sapiens	117-121
9517483-4	1997	The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic-AMP Early Repressor), a powerful repressor of cAMP-induced transcription.	Cyclic AMP	186-190	cAMP responsive element modulator	Homo sapiens	123-159
9517483-5	1997	Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate.	Colforsin	125-134	cAMP responsive element modulator	Homo sapiens	18-22
9517483-5	1997	Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate.	Glutamic Acid	139-148	cAMP responsive element modulator	Homo sapiens	18-22
9395245-0	1997	Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor.	Cyclic AMP	62-66	cAMP responsive element modulator	Homo sapiens	104-108
9395245-1	1997	The CREM gene encodes both activators and repressors of cAMP-induced transcription.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	4-8
9395245-3	1997	ICER acts as a dominant negative regulator and is cAMP-inducible in various neuroendocrine cells and tissues.	Cyclic AMP	50-54	cAMP responsive element modulator	Homo sapiens	0-4
9395245-6	1997	This is the first example of cAMP-independent induction of ICER expression.	Cyclic AMP	29-33	cAMP responsive element modulator	Homo sapiens	59-63
9247115-0	1997	Cyclic AMP signalling and cellular proliferation: regulation of CREB and CREM.	Cyclic AMP	0-10	cAMP responsive element modulator	Homo sapiens	64-68
9347618-4	1997	The molecular mechanisms involved in rhythmic synthesis of melatonin involve the cAMP response element modulator (crem) gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway.	Melatonin	59-68	cAMP responsive element modulator	Homo sapiens	81-112
9347618-4	1997	The molecular mechanisms involved in rhythmic synthesis of melatonin involve the cAMP response element modulator (crem) gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway.	Melatonin	59-68	cAMP responsive element modulator	Homo sapiens	114-118
9347618-4	1997	The molecular mechanisms involved in rhythmic synthesis of melatonin involve the cAMP response element modulator (crem) gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway.	Cyclic AMP	81-85	cAMP responsive element modulator	Homo sapiens	114-118
9347618-5	1997	The CREM product, inducible cAMP early repressor (ICER), is rhythmically expressed and participates in a transcriptional autoregulatory loop that also controls the amplitude of oscillations of 5-HT N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis.	Melatonin	248-257	cAMP responsive element modulator	Homo sapiens	4-8
9347618-5	1997	The CREM product, inducible cAMP early repressor (ICER), is rhythmically expressed and participates in a transcriptional autoregulatory loop that also controls the amplitude of oscillations of 5-HT N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis.	Melatonin	248-257	cAMP responsive element modulator	Homo sapiens	18-48
9347618-5	1997	The CREM product, inducible cAMP early repressor (ICER), is rhythmically expressed and participates in a transcriptional autoregulatory loop that also controls the amplitude of oscillations of 5-HT N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis.	Melatonin	248-257	cAMP responsive element modulator	Homo sapiens	50-54
9247115-0	1997	Cyclic AMP signalling and cellular proliferation: regulation of CREB and CREM.	Cyclic AMP	0-10	cAMP responsive element modulator	Homo sapiens	73-77
8994192-8	1997	By in vitro transcription/translation of all six CREM cDNAs, we demonstrated internal translation initiation at three different methionine residues, giving rise to novel short and very short C-terminal proteins comprising DBD I.	Methionine	128-138	cAMP responsive element modulator	Homo sapiens	49-53
8994192-13	1997	In contrast, ICER transcripts were strongly up-regulated in decidualized ES cells in parallel with the induction of dPRL expression.	Einsteinium	73-75	cAMP responsive element modulator	Homo sapiens	13-17
8994192-14	1997	It appears paradoxical that in vivo, in response to a permanent cAMP stimulus, ICER is up-regulated without displaying negative autoregulation of its own gene or suppression of the dPRL promoter.	Cyclic AMP	64-68	cAMP responsive element modulator	Homo sapiens	79-83
8994192-15	1997	Elevated ICER levels in decidualized ES cells may be indicative of the presence of overriding amounts of transcriptional activators such as full length CREM-tau or CREB which, in turn, upon cAMP-induced phosphorylation, contribute to the induction of the dPRL gene.	Cyclic AMP	190-194	cAMP responsive element modulator	Homo sapiens	9-13
8994192-15	1997	Elevated ICER levels in decidualized ES cells may be indicative of the presence of overriding amounts of transcriptional activators such as full length CREM-tau or CREB which, in turn, upon cAMP-induced phosphorylation, contribute to the induction of the dPRL gene.	Cyclic AMP	190-194	cAMP responsive element modulator	Homo sapiens	152-156
8622971-0	1996	cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	47-51
18406739-0	1996	Role of transcription factors CREB and CREM in cAMP-regulated transcription during spermatogenesis.	Cyclic AMP	47-51	cAMP responsive element modulator	Homo sapiens	39-43
18406739-2	1996	Cyclical expression of CREB and CREM in germ and somatic Sertoli cells correlates with the fluctuations in cAMP signaling induced by the pituitary gonadotropic hormones FSH and LH both during sexual maturation of the testis and during the 12-day cycles of spermatogenesis that occur in the adult testis.	Cyclic AMP	107-111	cAMP responsive element modulator	Homo sapiens	32-36
18406739-3	1996	CREB and CREM are expressed at different times during the spermatogenic cycle, undergo programmed sequential switches from activator to repressor isoforms by mechanisms of alternative exon splicing and promoter usage, and are autoregulated by cAMP signaling in opposing directions.	Cyclic AMP	243-247	cAMP responsive element modulator	Homo sapiens	9-13
18406739-4	1996	cAMP response elements located in the promoter of the CREB gene upregulate the expression of activator CREBs, whereas cAMP autoregulatory response elements in the internal promoter of the CREM gene induce expression of repressor CREM isoforms.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	229-233
18406739-4	1996	cAMP response elements located in the promoter of the CREB gene upregulate the expression of activator CREBs, whereas cAMP autoregulatory response elements in the internal promoter of the CREM gene induce expression of repressor CREM isoforms.	Cyclic AMP	118-122	cAMP responsive element modulator	Homo sapiens	188-192
18406739-4	1996	cAMP response elements located in the promoter of the CREB gene upregulate the expression of activator CREBs, whereas cAMP autoregulatory response elements in the internal promoter of the CREM gene induce expression of repressor CREM isoforms.	Cyclic AMP	118-122	cAMP responsive element modulator	Homo sapiens	229-233
8609995-3	1996	ICER levels are regulated by light by means of the suprachiasmatic nucleus (SCN); transcription is induced during darkness by adrenergic input to the pineal gland from the SCN, which activates the ICER promoter using cyclic AMP and the transcriptional activator CREB.	Cyclic AMP	217-227	cAMP responsive element modulator	Homo sapiens	0-4
8609995-3	1996	ICER levels are regulated by light by means of the suprachiasmatic nucleus (SCN); transcription is induced during darkness by adrenergic input to the pineal gland from the SCN, which activates the ICER promoter using cyclic AMP and the transcriptional activator CREB.	Cyclic AMP	217-227	cAMP responsive element modulator	Homo sapiens	197-201
8735279-0	1996	CREM: a master-switch in the transcriptional response to cAMP.	Cyclic AMP	57-61	cAMP responsive element modulator	Homo sapiens	0-4
8735279-1	1996	The CREM gene encodes both repressors and activators of cAMP-dependent transcription in a tissue and developmentally regulated manner.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	4-8
8735279-6	1996	CREM is inducible by activation of the cAMP signalling pathway with the kinetics of an early response gene.	Cyclic AMP	39-43	cAMP responsive element modulator	Homo sapiens	0-4
8735279-10	1996	ICER functions as a powerful repressor of cAMP-induced transcription, and represses the activity of its own promoter, thus constituting a negative autoregulatory loop.	Cyclic AMP	42-46	cAMP responsive element modulator	Homo sapiens	0-4
8622971-3	1996	Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	120-124
8622971-3	1996	Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible cAMP early repressor) previously described in the hypothalamic-pituitary-gonadal axis.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	126-156
8622971-5	1996	Thus, the induction of ICER in T cells may play an important role in the cAMP-induced quiescence and the persistent latency of HTLV-I.	Cyclic AMP	73-77	cAMP responsive element modulator	Homo sapiens	23-27
7479863-1	1995	Transcription factor CREM (cAMP-responsive element modulator) plays a pivotal role in the nuclear response to cAMP in neuroendocrine cells.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	21-25
8650267-0	1996	The nuclear response to cAMP: role of transcription factor CREM.	Cyclic AMP	24-28	cAMP responsive element modulator	Homo sapiens	59-63
7760825-0	1995	Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM.	Cyclic AMP	57-67	cAMP responsive element modulator	Homo sapiens	110-114
7651429-1	1995	We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM.	Cyclic AMP	92-102	cAMP responsive element modulator	Homo sapiens	152-156
7651429-1	1995	We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM.	Cyclic AMP	104-108	cAMP responsive element modulator	Homo sapiens	152-156
7642572-0	1995	The cyclic AMP response elements of the genes for angiotensin converting enzyme and phosphoenolpyruvate carboxykinase (GTP) can mediate transcriptional activation by CREM tau and CREM alpha.	Cyclic AMP	4-14	cAMP responsive element modulator	Homo sapiens	166-170
7642572-0	1995	The cyclic AMP response elements of the genes for angiotensin converting enzyme and phosphoenolpyruvate carboxykinase (GTP) can mediate transcriptional activation by CREM tau and CREM alpha.	Cyclic AMP	4-14	cAMP responsive element modulator	Homo sapiens	179-183
7642572-0	1995	The cyclic AMP response elements of the genes for angiotensin converting enzyme and phosphoenolpyruvate carboxykinase (GTP) can mediate transcriptional activation by CREM tau and CREM alpha.	Guanosine Triphosphate	119-122	cAMP responsive element modulator	Homo sapiens	166-170
7642572-0	1995	The cyclic AMP response elements of the genes for angiotensin converting enzyme and phosphoenolpyruvate carboxykinase (GTP) can mediate transcriptional activation by CREM tau and CREM alpha.	Guanosine Triphosphate	119-122	cAMP responsive element modulator	Homo sapiens	179-183
7642572-1	1995	The potential of the CREM family of proteins to activate transcription of the genes encoding the testis-specific isozyme of angiotensin converting enzyme (ACET) and the gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (GTP) (PEPCK) (EC 4.1.1.32) were investigated.	Guanosine Triphosphate	226-229	cAMP responsive element modulator	Homo sapiens	21-25
7642572-2	1995	Both CREM tau and CREM alpha bind efficiently to the putative cyclic AMP response element (CRE) present in the ACET gene (CRET) and to the CRE in the PEPCK gene.	Cyclic AMP	62-72	cAMP responsive element modulator	Homo sapiens	5-9
7642572-2	1995	Both CREM tau and CREM alpha bind efficiently to the putative cyclic AMP response element (CRE) present in the ACET gene (CRET) and to the CRE in the PEPCK gene.	Cyclic AMP	62-72	cAMP responsive element modulator	Homo sapiens	18-22
7673120-3	1995	This promoter contains two cAMP response element-like motifs that bind the testis-specific transcription factor CREM tau.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	112-116
7673120-5	1995	Here we describe a novel regulatory element, the 111-base pair first intron of the calspermin gene, which is also required for enhancement of transcription by CREM tau via the cAMP response element motifs.	Cyclic AMP	176-180	cAMP responsive element modulator	Homo sapiens	159-163
8531048-8	1995	Recently, the deciphering of molecular determinants regulating expression of cAMP-inducible genes in the mammalian pineal gland, like NAT, c-jun, or the beta-adrenergic receptor suggests a modulation in their transcription by a dual regulatory mechanism: posttranslational activation of the early third messenger CREB (cAMP responsive element binding protein) stimulates, cis-acting cAMP-induced transcriptional upregulation of the late third messenger ICER (inducible cAMP early repressor) inhibits genes with a CRE.	Cyclic AMP	77-81	cAMP responsive element modulator	Homo sapiens	453-457
8531048-8	1995	Recently, the deciphering of molecular determinants regulating expression of cAMP-inducible genes in the mammalian pineal gland, like NAT, c-jun, or the beta-adrenergic receptor suggests a modulation in their transcription by a dual regulatory mechanism: posttranslational activation of the early third messenger CREB (cAMP responsive element binding protein) stimulates, cis-acting cAMP-induced transcriptional upregulation of the late third messenger ICER (inducible cAMP early repressor) inhibits genes with a CRE.	Cyclic AMP	77-81	cAMP responsive element modulator	Homo sapiens	459-489
8531048-8	1995	Recently, the deciphering of molecular determinants regulating expression of cAMP-inducible genes in the mammalian pineal gland, like NAT, c-jun, or the beta-adrenergic receptor suggests a modulation in their transcription by a dual regulatory mechanism: posttranslational activation of the early third messenger CREB (cAMP responsive element binding protein) stimulates, cis-acting cAMP-induced transcriptional upregulation of the late third messenger ICER (inducible cAMP early repressor) inhibits genes with a CRE.	Cyclic AMP	319-323	cAMP responsive element modulator	Homo sapiens	453-457
8531048-8	1995	Recently, the deciphering of molecular determinants regulating expression of cAMP-inducible genes in the mammalian pineal gland, like NAT, c-jun, or the beta-adrenergic receptor suggests a modulation in their transcription by a dual regulatory mechanism: posttranslational activation of the early third messenger CREB (cAMP responsive element binding protein) stimulates, cis-acting cAMP-induced transcriptional upregulation of the late third messenger ICER (inducible cAMP early repressor) inhibits genes with a CRE.	Cyclic AMP	319-323	cAMP responsive element modulator	Homo sapiens	459-489
7923380-0	1994	Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	53-57
7483321-0	1995	cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator.	Cyclic AMP	0-4	cAMP responsive element modulator	Homo sapiens	93-124
7730336-5	1995	Because ATF-1 and CREM are known to bind to cAMP response elements (CRE), this functional sequence was named the kappa E3"-CRE.	Cyclic AMP	44-48	cAMP responsive element modulator	Homo sapiens	18-22
7730336-6	1995	We show that dibutyryl cAMP can increase kappa E3" enhancer activity, and in transient expression assays ATF-1 caused a 4-5-fold increase in the activity of the core enhancer while CREM-alpha expression resulted in repression of enhancer activity.	Cyclic AMP	23-27	cAMP responsive element modulator	Homo sapiens	181-185
7923380-2	1994	Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117.	Serine	86-92	cAMP responsive element modulator	Homo sapiens	15-28
7923380-2	1994	Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117.	Serine	86-92	cAMP responsive element modulator	Homo sapiens	30-34
7923380-6	1994	The macrolide rapamycin, a potent and specific inhibitor of p70S6K in vivo, completely blocks CREM activation induced by serum and by p70S6K.	Macrolides	4-13	cAMP responsive element modulator	Homo sapiens	94-98
7923380-6	1994	The macrolide rapamycin, a potent and specific inhibitor of p70S6K in vivo, completely blocks CREM activation induced by serum and by p70S6K.	Sirolimus	14-23	cAMP responsive element modulator	Homo sapiens	94-98
8206879-0	1994	Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA.	Cyclic AMP	24-34	cAMP responsive element modulator	Homo sapiens	65-70
8056145-0	1994	The key role of CREM in the cAMP signaling pathway in the testis.	Cyclic AMP	28-32	cAMP responsive element modulator	Homo sapiens	16-20
8132092-0	1993	Nuclear response to cyclic AMP: central role of transcription factor CREM (cyclic-AMP-responsive-element modulator).	Cyclic AMP	20-30	cAMP responsive element modulator	Homo sapiens	69-73
8290258-4	1994	We have been studying the cAMP-responsive-element modulator (CREM) gene, which encodes both repressors (CREM alpha, beta and gamma) and an activator (CREM tau) of cAMP-responsive transcription by alternative splicing.	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	61-65
8290258-4	1994	We have been studying the cAMP-responsive-element modulator (CREM) gene, which encodes both repressors (CREM alpha, beta and gamma) and an activator (CREM tau) of cAMP-responsive transcription by alternative splicing.	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	104-108
8290258-4	1994	We have been studying the cAMP-responsive-element modulator (CREM) gene, which encodes both repressors (CREM alpha, beta and gamma) and an activator (CREM tau) of cAMP-responsive transcription by alternative splicing.	Cyclic AMP	26-30	cAMP responsive element modulator	Homo sapiens	104-108
8252624-2	1993	Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway.	Cyclic AMP	56-60	cAMP responsive element modulator	Homo sapiens	20-24
8252624-2	1993	Here we report that CREM is unique within the family of cAMP-responsive promoter element (CRE)-binding factors since it is inducible by activation of the cAMP signaling pathway.	Cyclic AMP	154-158	cAMP responsive element modulator	Homo sapiens	20-24
8132092-0	1993	Nuclear response to cyclic AMP: central role of transcription factor CREM (cyclic-AMP-responsive-element modulator).	Cyclic AMP	20-30	cAMP responsive element modulator	Homo sapiens	75-114
8114765-1	1993	The cAMP-responsive element modulator (CREM) gene encodes a family of transcriptional regulators that bind to promoter sequences activated by increased intracellular cAMP levels.	Cyclic AMP	4-8	cAMP responsive element modulator	Homo sapiens	39-43
7916662-1	1993	The CREM (cyclic AMP-responsive element modulator) gene encodes multiple regulators of the cyclic AMP transcriptional response.	Cyclic AMP	10-20	cAMP responsive element modulator	Homo sapiens	4-8
8114765-6	1993	We show that CREM tau is efficiently phosphorylated at a serine residue at position 117 by the protein kinase-A endogenous to germ cells, indicating that it constitutes a natural target of the adenylyl cyclase pathway during spermatogenesis.	Serine	57-63	cAMP responsive element modulator	Homo sapiens	13-17
8114765-7	1993	Phosphorylation of serine-117 turns CREM tau into a powerful activator.	Serine	19-25	cAMP responsive element modulator	Homo sapiens	36-40
1461747-0	1992	Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes.	Cyclic AMP	0-10	cAMP responsive element modulator	Homo sapiens	71-75
8404858-3	1993	We show that the CREM tau activator is phosphorylated on multiple serine and threonine residues in vivo.	Serine	66-72	cAMP responsive element modulator	Homo sapiens	17-21
8404858-3	1993	We show that the CREM tau activator is phosphorylated on multiple serine and threonine residues in vivo.	Threonine	77-86	cAMP responsive element modulator	Homo sapiens	17-21
8404858-4	1993	Stimulation of various signal transduction pathways by forskolin, TPA or Ca2+ ionophore leads to enhanced phosphorylation of serine 117, concomitant with an increase in the transactivation potential of CREM tau.	Colforsin	55-64	cAMP responsive element modulator	Homo sapiens	202-206
8404858-4	1993	Stimulation of various signal transduction pathways by forskolin, TPA or Ca2+ ionophore leads to enhanced phosphorylation of serine 117, concomitant with an increase in the transactivation potential of CREM tau.	Serine	125-131	cAMP responsive element modulator	Homo sapiens	202-206
8397338-4	1993	ICER is generated from an alternative, intronic promoter and functions as a powerful repressor of cyclic AMP-induced transcription.	Cyclic AMP	98-108	cAMP responsive element modulator	Homo sapiens	0-4
8397338-5	1993	Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.	Cyclic AMP	97-101	cAMP responsive element modulator	Homo sapiens	59-63
8458330-1	1993	The CREM gene (cAMP-responsive element modulator) generates both activators and repressors of cAMP-induced transcription by alternative splicing.	Cyclic AMP	15-19	cAMP responsive element modulator	Homo sapiens	4-8
8458330-7	1993	A minimal CREM repressor, containing only the b-Zip motif, efficiently antagonizes cAMP-induced transcription.	Cyclic AMP	83-87	cAMP responsive element modulator	Homo sapiens	10-14
8458330-8	1993	In addition, phosphorylation may reduce repressor function, as a CREM beta mutant carrying a mutation of the serine phosphoacceptor site (CREM beta 68) represses more efficiently than the wild-type CREM beta.	Serine	109-115	cAMP responsive element modulator	Homo sapiens	65-69
8458330-8	1993	In addition, phosphorylation may reduce repressor function, as a CREM beta mutant carrying a mutation of the serine phosphoacceptor site (CREM beta 68) represses more efficiently than the wild-type CREM beta.	Serine	109-115	cAMP responsive element modulator	Homo sapiens	138-142
8458330-8	1993	In addition, phosphorylation may reduce repressor function, as a CREM beta mutant carrying a mutation of the serine phosphoacceptor site (CREM beta 68) represses more efficiently than the wild-type CREM beta.	Serine	109-115	cAMP responsive element modulator	Homo sapiens	138-142
35457683-11	2022	Nemonoxacin and moxifloxacin were dominant compared with levofloxacin, and the ICER of moxifloxacin compared with nemonoxacin was $551,643, which was much greater than WTP; therefore, nemonoxacin was the most cost-effective option.	Moxifloxacin	87-99	cAMP responsive element modulator	Homo sapiens	79-83
1429597-5	1992	The gene CRE modulator (CREM) encodes both antagonists and an activator of the cAMP transcriptional response by alternative splicing.	Cyclic AMP	79-83	cAMP responsive element modulator	Homo sapiens	9-22
1429597-5	1992	The gene CRE modulator (CREM) encodes both antagonists and an activator of the cAMP transcriptional response by alternative splicing.	Cyclic AMP	79-83	cAMP responsive element modulator	Homo sapiens	24-28
21584557-1	1992	The proteins binding the cAMP responsive elements constitute a family of transcription factors (e.g. CREB 327/341, ATF, HB16, CREM) which operate as dimers and regulate positively and negatively gene expression upon interaction with the cAMP responsive motifs CRE/ATF.	Cyclic AMP	25-29	cAMP responsive element modulator	Homo sapiens	126-130
21584557-1	1992	The proteins binding the cAMP responsive elements constitute a family of transcription factors (e.g. CREB 327/341, ATF, HB16, CREM) which operate as dimers and regulate positively and negatively gene expression upon interaction with the cAMP responsive motifs CRE/ATF.	Cyclic AMP	237-241	cAMP responsive element modulator	Homo sapiens	126-130
1647033-0	1991	Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.	Cyclic AMP	27-31	cAMP responsive element modulator	Homo sapiens	62-66
32834722-0	2020	ICER update to pricing models of remdesivir for COVID-19.	remdesivir	33-43	cAMP responsive element modulator	Homo sapiens	0-4
20492762-24	2010	The new decision model indicated that eplerenone was the most cost-effective strategy for postMI HF (ICER of eplerenone compared with standard care was 4457 pounds per QALY, increasing to 7893 pounds per QALY if treatment continued over the patient"s lifetime); in neither scenario did spironolactone appear cost-effective.	Eplerenone	38-48	cAMP responsive element modulator	Homo sapiens	101-105
20492762-24	2010	The new decision model indicated that eplerenone was the most cost-effective strategy for postMI HF (ICER of eplerenone compared with standard care was 4457 pounds per QALY, increasing to 7893 pounds per QALY if treatment continued over the patient"s lifetime); in neither scenario did spironolactone appear cost-effective.	Eplerenone	109-119	cAMP responsive element modulator	Homo sapiens	101-105
20492762-25	2010	The ICER of eplerenone was consistently under the 20,000-30,000 pounds per QALY threshold used to establish value for money in the NHS.	Eplerenone	12-22	cAMP responsive element modulator	Homo sapiens	4-8
34938728-4	2021	By GSEA cluster analysis, we found that the high expression of CREM was associated with the cancer-associated pathway in GAC.	gsea	3-7	cAMP responsive element modulator	Homo sapiens	63-67
34587969-9	2021	We found treatment with DOACs would result in a large reduction in cost ($USD 1447.22 vs. $USD 3374.70) but a small reduction in QALYs (3.07 QALYs vs. 3.09 QALYs) compared with LMWHs over a 5-year time frame, resulting in an ICER of $USD 112895.50/QALYs.	doacs	24-29	cAMP responsive element modulator	Homo sapiens	225-229
34261344-1	2021	Cyclic AMP element modulator (CREM) is a transcription factor best known for its intricate involvement in spermatogenesis.	Cyclic AMP	0-10	cAMP responsive element modulator	Homo sapiens	30-34
34307303-6	2021	The resulting huAChE+BACE1-ICER/MS was characterized by using acetylcholine (ACh) and JMV2236 as substrates.	Acetylcholine	62-75	cAMP responsive element modulator	Homo sapiens	27-31
34307303-6	2021	The resulting huAChE+BACE1-ICER/MS was characterized by using acetylcholine (ACh) and JMV2236 as substrates.	Acetylcholine	77-80	cAMP responsive element modulator	Homo sapiens	27-31
34307303-6	2021	The resulting huAChE+BACE1-ICER/MS was characterized by using acetylcholine (ACh) and JMV2236 as substrates.	jmv2236	86-93	cAMP responsive element modulator	Homo sapiens	27-31
1370576-3	1992	We have previously described the CREM (cyclic AMP-responsive element modulator) gene which generates, by cell-specific splicing, alternative antagonists of the cAMP transcriptional response.	Cyclic AMP	160-164	cAMP responsive element modulator	Homo sapiens	33-37
1370576-3	1992	We have previously described the CREM (cyclic AMP-responsive element modulator) gene which generates, by cell-specific splicing, alternative antagonists of the cAMP transcriptional response.	Cyclic AMP	160-164	cAMP responsive element modulator	Homo sapiens	39-78
1370576-5	1992	CREM tau differs from the previously characterized CREM antagonists by the coordinate insertion of two glutamine-rich domains that confer transcriptional activation function.	Glutamine	103-112	cAMP responsive element modulator	Homo sapiens	0-4
1370576-5	1992	CREM tau differs from the previously characterized CREM antagonists by the coordinate insertion of two glutamine-rich domains that confer transcriptional activation function.	Glutamine	103-112	cAMP responsive element modulator	Homo sapiens	51-55
1329990-3	1992	Here we discuss the links between the activation of the adenylyl cyclase pathway and the transcriptional response of cAMP-inducible genes that is achieved by the interplay of a multitude of nuclear transcription factors such as CREB and CREM.	Cyclic AMP	117-121	cAMP responsive element modulator	Homo sapiens	237-241
1647033-5	1991	We present evidence that the transcriptional antagonist CRE modulator (CREM) can bind to c-fos CRE and heterodimerize with activator CRE-binding protein, thereby blocking cAMP induction.	Cyclic AMP	171-175	cAMP responsive element modulator	Homo sapiens	56-69
1647033-5	1991	We present evidence that the transcriptional antagonist CRE modulator (CREM) can bind to c-fos CRE and heterodimerize with activator CRE-binding protein, thereby blocking cAMP induction.	Cyclic AMP	171-175	cAMP responsive element modulator	Homo sapiens	71-75
1647033-6	1991	Furthermore, expression of antisense CREM enhances c-fos basal and cAMP-induced transcription.	Cyclic AMP	67-71	cAMP responsive element modulator	Homo sapiens	37-41
34783021-8	2022	RESULTS: RA patients exhibited increased CREM expression (P < 0.0001), which was decreased by methotrexate (P = 0.0223) and biologics (P = 0.0001), but could not be attributed to CREM variants.	Methotrexate	94-106	cAMP responsive element modulator	Homo sapiens	41-45
35418836-8	2022	The accumulation of proBDNF results in signaling that increases the expression of the inducible cAMP early repressor (ICER) protein which then occupies the cAMP response element (CRE)-binding sites within the BDNF promoters II and IV, thus altering normal synaptic plasticity.	Cyclic AMP	156-160	cAMP responsive element modulator	Homo sapiens	86-123
35308676-12	2022	The ICER for prevention of hospitalization with HF with dapagliflozin substitution is INR 1,320,040-1,435,543; INR 4,010,706 with empagliflozin and INR 5,548,000 with canagliflozin.	dapagliflozin	56-69	cAMP responsive element modulator	Homo sapiens	4-8
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	193-203	cAMP responsive element modulator	Homo sapiens	177-181
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	193-203	cAMP responsive element modulator	Homo sapiens	182-186
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	205-209	cAMP responsive element modulator	Homo sapiens	177-181
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	205-209	cAMP responsive element modulator	Homo sapiens	182-186
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	250-254	cAMP responsive element modulator	Homo sapiens	177-181
35041523-3	2022	We identified differential gene expression patterns that are specific to ECs and may influence HIV resistance, including alternative RNA splicing and exon usage variants of the CREM/ICER gene (cyclic AMP (cAMP)-responsive element modulator/inducible cAMP early repressors).	Cyclic AMP	250-254	cAMP responsive element modulator	Homo sapiens	182-186
35089941-10	2022	RESULTS: The ICER for allopurinol versus no ULT was $1,381, when combined with naproxen.	Allopurinol	22-33	cAMP responsive element modulator	Homo sapiens	13-17
35089941-11	2022	Febuxostat yielded the highest utility, but also the highest costs ($4,385 vs. $4,063 for allopurinol), resulting in an ICER of $25,173 when compared to allopurinol.	Febuxostat	0-10	cAMP responsive element modulator	Homo sapiens	120-124