PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2605349-0	1989	Hormonal control of polyamine pools in experimental breast cancer in vivo: correlation with estrogen and progesterone receptor levels.	Polyamines	20-29	progesterone receptor	Rattus norvegicus	105-126
2926313-10	1989	Thus, the tissue retains its ability to respond to progesterone because of a high concentration of progesterone receptor.	Progesterone	51-63	progesterone receptor	Rattus norvegicus	99-120
2770296-7	1989	In the primary culture and in it"s first subculture the cells responded to estradiol with a 2-3-fold increase in progesterone receptor level.	Estradiol	75-84	progesterone receptor	Rattus norvegicus	113-134
2721449-0	1989	Serum and monohydroxytamoxifen inhibit progesterone receptor concentrations in primary rat uterine cells grown in serum-free medium.	monohydroxytamoxifen	10-30	progesterone receptor	Rattus norvegicus	39-60
2721449-4	1989	Uterine cells grown in ITS contain PgR levels that are near maximum (927 +/- 168 fmol/mg protein), and estradiol (0.1 nM; 24 h) causes a 10-50% increase in PgR.	Estradiol	103-112	progesterone receptor	Rattus norvegicus	156-159
2721449-5	1989	Addition of serum or monohydroxytamoxifen for 24 h decreases PgR levels by about 50%, and estrogen can completely overcome the inhibition caused by either serum or monohydroxytamoxifen.	monohydroxytamoxifen	21-41	progesterone receptor	Rattus norvegicus	61-64
2512479-3	1989	The ER and PgR contents markedly decreased following chemo-endocrine therapy and endocrine therapy (TAM), but no significant decrease was achieved by chemotherapy (5-FU) alone.	Tamoxifen	100-103	progesterone receptor	Rattus norvegicus	11-14
2569332-0	1989	Beta-adrenergic receptors in DMBA-induced rat mammary tumors: correlation with progesterone receptor and tumor growth.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	29-33	progesterone receptor	Rattus norvegicus	79-100
2522157-4	1989	Tamoxifen (TAM) (0.1 mg/kg) priming induced PgR more frequently than TAM (0.4 mg/kg) priming.	Tamoxifen	0-9	progesterone receptor	Rattus norvegicus	44-47
2926313-11	1989	It is difficult to attribute this high tissue progesterone receptor concentration to oestradiol stimulation since, even at low levels, oestradiol induces tissue regression.	Estradiol	135-145	progesterone receptor	Rattus norvegicus	46-67
2522157-4	1989	Tamoxifen (TAM) (0.1 mg/kg) priming induced PgR more frequently than TAM (0.4 mg/kg) priming.	Tamoxifen	11-14	progesterone receptor	Rattus norvegicus	44-47
2500626-2	1989	Neither the incidence nor the size of the tumors was affected by the 1,25-(OH)2D3 treatment (1 or 2 micrograms twice a week for 16 weeks) but estrogen and progesterone receptor contents of the tumors were significantly lower in 1,25-(OH)2D3-treated groups as compared to the control group.	Calcitriol	228-240	progesterone receptor	Rattus norvegicus	155-176
2500626-3	1989	These results demonstrate that 1,25-(OH)2D3 at doses producing mild hypercalcemia does not affect the development of DMBA-induced rat mammary tumors but decreases the estrogen and progesterone receptor contents of the tumors.	Calcitriol	31-43	progesterone receptor	Rattus norvegicus	180-201
3123757-3	1987	ER and PRL-R were low but PgR increased significantly in the tumor of the tamoxifen-treated rats.	Tamoxifen	74-83	progesterone receptor	Rattus norvegicus	26-29
3139361-3	1988	The following ranking (low to high) for the RBA of the nuclear (intact cells) progesterone receptor irrespective of the ligand used is found: norethisterone much less than levonorgestrel less than 3-keto-destogestrel less than gestodene.	Norethindrone	142-156	progesterone receptor	Rattus norvegicus	78-99
3139361-3	1988	The following ranking (low to high) for the RBA of the nuclear (intact cells) progesterone receptor irrespective of the ligand used is found: norethisterone much less than levonorgestrel less than 3-keto-destogestrel less than gestodene.	Levonorgestrel	172-186	progesterone receptor	Rattus norvegicus	78-99
3139361-3	1988	The following ranking (low to high) for the RBA of the nuclear (intact cells) progesterone receptor irrespective of the ligand used is found: norethisterone much less than levonorgestrel less than 3-keto-destogestrel less than gestodene.	3-keto-destogestrel	197-216	progesterone receptor	Rattus norvegicus	78-99
3139361-3	1988	The following ranking (low to high) for the RBA of the nuclear (intact cells) progesterone receptor irrespective of the ligand used is found: norethisterone much less than levonorgestrel less than 3-keto-destogestrel less than gestodene.	Gestodene	227-236	progesterone receptor	Rattus norvegicus	78-99
3139361-8	1988	The selectivity indices (ratio of the mean RBA for the progesterone receptor to that of androgen receptor) in intact cells are significantly higher for 3-keto-desogestrel and gestodene than for levonorgestrel and norethisterone.	etonogestrel	152-170	progesterone receptor	Rattus norvegicus	55-76
3139361-8	1988	The selectivity indices (ratio of the mean RBA for the progesterone receptor to that of androgen receptor) in intact cells are significantly higher for 3-keto-desogestrel and gestodene than for levonorgestrel and norethisterone.	Gestodene	175-184	progesterone receptor	Rattus norvegicus	55-76
3139361-8	1988	The selectivity indices (ratio of the mean RBA for the progesterone receptor to that of androgen receptor) in intact cells are significantly higher for 3-keto-desogestrel and gestodene than for levonorgestrel and norethisterone.	Levonorgestrel	194-208	progesterone receptor	Rattus norvegicus	55-76
3139361-8	1988	The selectivity indices (ratio of the mean RBA for the progesterone receptor to that of androgen receptor) in intact cells are significantly higher for 3-keto-desogestrel and gestodene than for levonorgestrel and norethisterone.	Norethindrone	213-227	progesterone receptor	Rattus norvegicus	55-76
3259159-9	1988	The data suggest that the ability of DES treatment to increase AR and PgR concentrations is associated with differentiation and/or the presence of stroma and that it is unrelated to androgen sensitivity.	Diethylstilbestrol	37-40	progesterone receptor	Rattus norvegicus	70-73
3255736-4	1988	The uterine uptake is selectively blocked by simultaneous injection of a large dose of unlabeled steroid, indicating that the uptake is mediated by a high affinity, low capacity binding system, presumably the progesterone receptor.	Steroids	97-104	progesterone receptor	Rattus norvegicus	209-230
3131115-9	1988	Furthermore, treatment with 4-OHA caused a reduction in uterine estrogen receptor and progesterone receptor levels.	formestane	28-33	progesterone receptor	Rattus norvegicus	86-107
3131115-10	1988	The reduction in uterine estrogen and progesterone receptor levels was also counteracted by the concomitant injection of flutamide, but not by enclomiphene.	Flutamide	121-130	progesterone receptor	Rattus norvegicus	38-59
3381634-0	1988	Effect of estradiol on the progesterone receptor and on morphological ultrastructures in the fetal and newborn uterus and ovary of the rat.	Estradiol	10-19	progesterone receptor	Rattus norvegicus	27-48
3381634-5	1988	Estradiol stimulated significantly the progesterone receptor in the fetal uterus at 20 days old.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	39-60
3260860-1	1988	Unsaturated long chain fatty acids are known to inhibit the binding between estrogen and estrogen receptor, or progesterone and progesterone receptor in rat uterus.	unsaturated long chain fatty acids	0-34	progesterone receptor	Rattus norvegicus	128-149
3448706-0	1987	Relationship between occupied form of nuclear estrogen receptor and cytosolic progesterone receptor or DNA synthesis in uteri of estradiol implanted rats.	Estradiol	129-138	progesterone receptor	Rattus norvegicus	78-99
3123757-4	1987	A single administration of 100 micrograms estradiol induced a transient decrease of ER and PRL-R, and an increase of PgR, in the DMBA-tumor.	Estradiol	42-51	progesterone receptor	Rattus norvegicus	117-120
3569136-6	1987	A single injection of progesterone 1 h before the second estradiol administration blocks the second peak of progesterone receptor in the anterior pituitary, but not in the hypothalamus.	Progesterone	22-34	progesterone receptor	Rattus norvegicus	108-129
2949071-7	1987	Parallel to the decreased affinity for the androgen and progesterone receptor in vitro, there was a 3- to 10-fold decrease of the antiandrogenic and progestagenic effect compared to spironolactone in the rat and in the rabbit, respectively.	Spironolactone	182-196	progesterone receptor	Rattus norvegicus	56-77
3720665-7	1986	However, injection of orchiectomized males with 17 beta-estradiol significantly (P less than 0.05) increased progesterone receptor content to 208 +/- 24 fmol/mg DNA.	Estradiol	48-65	progesterone receptor	Rattus norvegicus	109-130
3112670-0	1987	Priming action on progesterone receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma.	Tamoxifen	67-76	progesterone receptor	Rattus norvegicus	18-39
3112670-0	1987	Priming action on progesterone receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma.	7,12-dimethylbenz	84-101	progesterone receptor	Rattus norvegicus	18-39
3112670-0	1987	Priming action on progesterone receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma.	anthracene	104-114	progesterone receptor	Rattus norvegicus	18-39
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	Estradiol	22-31	progesterone receptor	Rattus norvegicus	72-93
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	Tamoxifen	53-62	progesterone receptor	Rattus norvegicus	72-93
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	Tamoxifen	53-62	progesterone receptor	Rattus norvegicus	95-98
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	Tamoxifen	64-67	progesterone receptor	Rattus norvegicus	72-93
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	Tamoxifen	64-67	progesterone receptor	Rattus norvegicus	95-98
3112670-1	1987	The priming action of estradiol and the antiestrogen tamoxifen (TMX) on progesterone receptor (PgR) synthesis has been investigated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor model testing different priming times.	anthracene	159-169	progesterone receptor	Rattus norvegicus	95-98
3112670-5	1987	PgR concentration increased after 3 days of either E2B or TMX administration, but decreased when treatment was prolonged to 7 days.	Tamoxifen	58-61	progesterone receptor	Rattus norvegicus	0-3
3112670-0	1987	Priming action on progesterone receptor synthesis by estradiol and tamoxifen in the 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinoma.	Estradiol	53-62	progesterone receptor	Rattus norvegicus	18-39
3595675-3	1986	In the R-27 cell line after 7 days of culture, the progesterone receptor (PR) concentrations were greatly increased by E3 and E3-3-sulfate; however, tamoxifen did not block this effect.	Estriol	119-121	progesterone receptor	Rattus norvegicus	51-72
3595675-3	1986	In the R-27 cell line after 7 days of culture, the progesterone receptor (PR) concentrations were greatly increased by E3 and E3-3-sulfate; however, tamoxifen did not block this effect.	Estriol	119-121	progesterone receptor	Rattus norvegicus	74-76
3595675-3	1986	In the R-27 cell line after 7 days of culture, the progesterone receptor (PR) concentrations were greatly increased by E3 and E3-3-sulfate; however, tamoxifen did not block this effect.	e3-3-sulfate	126-138	progesterone receptor	Rattus norvegicus	51-72
3595675-3	1986	In the R-27 cell line after 7 days of culture, the progesterone receptor (PR) concentrations were greatly increased by E3 and E3-3-sulfate; however, tamoxifen did not block this effect.	e3-3-sulfate	126-138	progesterone receptor	Rattus norvegicus	74-76
3720665-10	1986	The observation that 17 beta-estradiol modulates aortic progesterone receptor content indicates that rat aortic estrogen receptors are physiologically functional.	Estradiol	21-38	progesterone receptor	Rattus norvegicus	56-77
3724147-1	1986	Exchange assays have been validated to study several forms of the progesterone receptor found to occur in nuclei of rat placenta after extraction with high salt.	Salts	156-160	progesterone receptor	Rattus norvegicus	66-87
3716757-3	1986	A single ip injection of 10 micrograms oestradiol-17 beta (E2) in ovariectomized and adrenalectomized rats resulted in a significant increase in pituitary weight and progesterone receptor (PgR) concentration.	Estradiol	39-57	progesterone receptor	Rattus norvegicus	166-187
3716757-3	1986	A single ip injection of 10 micrograms oestradiol-17 beta (E2) in ovariectomized and adrenalectomized rats resulted in a significant increase in pituitary weight and progesterone receptor (PgR) concentration.	Estradiol	39-57	progesterone receptor	Rattus norvegicus	189-192
3716757-3	1986	A single ip injection of 10 micrograms oestradiol-17 beta (E2) in ovariectomized and adrenalectomized rats resulted in a significant increase in pituitary weight and progesterone receptor (PgR) concentration.	Estradiol	59-61	progesterone receptor	Rattus norvegicus	166-187
3716757-3	1986	A single ip injection of 10 micrograms oestradiol-17 beta (E2) in ovariectomized and adrenalectomized rats resulted in a significant increase in pituitary weight and progesterone receptor (PgR) concentration.	Estradiol	59-61	progesterone receptor	Rattus norvegicus	189-192
3716757-5	1986	However, 1 mg of dexamethasone (Dex) injected before E2, but not after E2 administration, completely inhibited both the increases in pituitary weight and PgR concentration.	Dexamethasone	17-30	progesterone receptor	Rattus norvegicus	154-157
3716757-5	1986	However, 1 mg of dexamethasone (Dex) injected before E2, but not after E2 administration, completely inhibited both the increases in pituitary weight and PgR concentration.	Dexamethasone	32-35	progesterone receptor	Rattus norvegicus	154-157
3716757-10	1986	A single ip injection of 250 micrograms clomiphene citrate (clomiphene) significantly reduced both the pituitary weight and PgR concentration in these animals, but 1 mg of Dex failed to have a similar effect.	Clomiphene	40-58	progesterone receptor	Rattus norvegicus	124-127
3716757-10	1986	A single ip injection of 250 micrograms clomiphene citrate (clomiphene) significantly reduced both the pituitary weight and PgR concentration in these animals, but 1 mg of Dex failed to have a similar effect.	Clomiphene	40-50	progesterone receptor	Rattus norvegicus	124-127
3724147-9	1986	Addition of 10 mM Na molybdate protected all forms of the nuclear progesterone receptor from thermal denaturation and extended the life of the complex 3-4-fold.	na molybdate	18-30	progesterone receptor	Rattus norvegicus	66-87
3724147-15	1986	Thus, the distinctive physicochemical properties responsible for KCl resistant and extractable forms of the nuclear progesterone receptor must reside in other domains of the receptor molecule.	Potassium Chloride	65-68	progesterone receptor	Rattus norvegicus	116-137
2423933-7	1986	In further studies, chlordecone"s effect on the CNS progesterone receptor was examined.	Chlordecone	20-31	progesterone receptor	Rattus norvegicus	52-73
2936712-3	1986	Since estradiol induces progesterone receptor formation, we compared the ventilatory effect of the synthetic progestin medroxyprogesterone acetate (MPA) given in combination with estradiol with the effects of estradiol alone, MPA alone, or vehicle (saline) in ovariectomized rats.	Estradiol	6-15	progesterone receptor	Rattus norvegicus	24-45
2954599-0	1986	Adrenal steroids stimulate growth and progesterone receptor levels in rat uterus and DMBA-induced mammary tumors.	Steroids	8-16	progesterone receptor	Rattus norvegicus	38-59
2954599-1	1986	We have studied the effect of treatment with the adrenal steroids androst-5-ene-3 beta,17 beta-diol (delta 5-diol) and dehydroepiandrosterone (DHEA) on the growth and progesterone receptor levels of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat.	Steroids	57-65	progesterone receptor	Rattus norvegicus	167-188
2954599-1	1986	We have studied the effect of treatment with the adrenal steroids androst-5-ene-3 beta,17 beta-diol (delta 5-diol) and dehydroepiandrosterone (DHEA) on the growth and progesterone receptor levels of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat.	Androstenediol	66-99	progesterone receptor	Rattus norvegicus	167-188
2954599-1	1986	We have studied the effect of treatment with the adrenal steroids androst-5-ene-3 beta,17 beta-diol (delta 5-diol) and dehydroepiandrosterone (DHEA) on the growth and progesterone receptor levels of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat.	delta 5-diol	101-113	progesterone receptor	Rattus norvegicus	167-188
2954599-7	1986	Treatment of ovariectomized animals with delta 5-diol and DHEA caused a marked increase (p less than 0.01) in progesterone receptor levels in both the uteri and DMBA-induced mammary tumors.	delta 5-diol	41-53	progesterone receptor	Rattus norvegicus	110-131
2954599-7	1986	Treatment of ovariectomized animals with delta 5-diol and DHEA caused a marked increase (p less than 0.01) in progesterone receptor levels in both the uteri and DMBA-induced mammary tumors.	Dehydroepiandrosterone	58-62	progesterone receptor	Rattus norvegicus	110-131
2954599-7	1986	Treatment of ovariectomized animals with delta 5-diol and DHEA caused a marked increase (p less than 0.01) in progesterone receptor levels in both the uteri and DMBA-induced mammary tumors.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	161-165	progesterone receptor	Rattus norvegicus	110-131
2935517-4	1985	All the ER(+) and PgR(-) tumors were transformed into PgR(+) after daily treatment with MPA for 2 weeks and then with TAM for another 2 weeks, but tumor regression was modest and none disappeared completely.	Medroxyprogesterone Acetate	88-91	progesterone receptor	Rattus norvegicus	54-57
3081323-2	1986	It is demonstrated that 17-alpha-hydroxyprogesterone capronate (HPC) alone administered once every 6 days reduces estradiol receptor (ER) and progesterone receptor (PR) levels and the frequency of R+ tumours.	17 alpha-Hydroxyprogesterone Caproate	24-62	progesterone receptor	Rattus norvegicus	142-163
3081323-2	1986	It is demonstrated that 17-alpha-hydroxyprogesterone capronate (HPC) alone administered once every 6 days reduces estradiol receptor (ER) and progesterone receptor (PR) levels and the frequency of R+ tumours.	17 alpha-Hydroxyprogesterone Caproate	24-62	progesterone receptor	Rattus norvegicus	165-167
3081323-4	1986	A high level of ER and PR and a high frequency of R+ tumours were observed after a successive administration of insulin, prednisolone, HPC and TS.	Prednisolone	121-133	progesterone receptor	Rattus norvegicus	23-25
3996316-7	1985	Using the 3-day uterine assay in vivo, 4-hydroxytamoxifen partially stimulated progesterone receptor induction in the immature rat, whereas it fully stimulated the same end point in the mature ovariectomized mouse.	hydroxytamoxifen	39-57	progesterone receptor	Rattus norvegicus	79-100
4040590-3	1985	In contrast to previous data significant binding to the progesterone receptor also occurs and future studies with this ligand should employ triamcinolone acetonide to block such binding.	Triamcinolone Acetonide	140-163	progesterone receptor	Rattus norvegicus	56-77
6489258-4	1984	ER is apparently functional at relatively low levels, since estradiol did induce PR synthesis, and cytosolic ER was reduced by estrogen administration.	Estradiol	60-69	progesterone receptor	Rattus norvegicus	81-83
3987619-1	1985	The rat uterus responds to estradiol (E2) and E2 benzoate stimulation with an increase in progesterone receptor production and with growth.	Estradiol	27-36	progesterone receptor	Rattus norvegicus	90-111
3987619-1	1985	The rat uterus responds to estradiol (E2) and E2 benzoate stimulation with an increase in progesterone receptor production and with growth.	e2 benzoate	46-57	progesterone receptor	Rattus norvegicus	90-111
6548377-3	1984	Tamoxifen also binds to anti-estrogen binding site but, unlike N,N-DPPE, binds significantly to estrogen receptor at much lower concentrations and induces MCF-7 progesterone receptor.	Tamoxifen	0-9	progesterone receptor	Rattus norvegicus	161-182
6714156-2	1984	Progesterone receptor is induced within 1 day of 17 beta-estradiol treatment, with maximal response occurring after 2 days of treatment (300-500% of the control value).	Estradiol	49-66	progesterone receptor	Rattus norvegicus	0-21
6465854-6	1984	This increase in the PgR levels is initially dose-dependent up to 10 micrograms of Tamoxifen per day reaching maximal levels after 4 days of treatment.	Tamoxifen	83-92	progesterone receptor	Rattus norvegicus	21-24
6745180-2	1984	Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh medium, no increase in progesterone receptors was observed.	Estradiol	38-55	progesterone receptor	Rattus norvegicus	100-121
6714156-3	1984	Induction of progesterone receptor occurred at physiological 17 beta-estradiol concentrations, with half-maximal response at about 5 X 10(-11) M. 17 beta-Estradiol induced the synthesis of a secreted protein (mol wt, 130,000) in a dose-dependent fashion.	Estradiol	61-78	progesterone receptor	Rattus norvegicus	13-34
6714156-3	1984	Induction of progesterone receptor occurred at physiological 17 beta-estradiol concentrations, with half-maximal response at about 5 X 10(-11) M. 17 beta-Estradiol induced the synthesis of a secreted protein (mol wt, 130,000) in a dose-dependent fashion.	Estradiol	146-163	progesterone receptor	Rattus norvegicus	13-34
6321624-5	1984	However, oestradiol administration caused an induction of these receptors in the immature rat uterus, together with a significant increase in the uterine weight, progesterone receptor level and peroxidase activity.	Estradiol	9-19	progesterone receptor	Rattus norvegicus	162-183
6230984-3	1983	Tamoxifen in contrast to estradiol does not significantly affect tissue growth, while PgR induction is considerably stimulated by Tamoxifen.	Tamoxifen	130-139	progesterone receptor	Rattus norvegicus	86-89
6861693-12	1983	The requirement for maintenance of a background level of estrogen suggests that the inhibitory action of progesterone is mediated through progesterone receptor interactions.	Progesterone	105-117	progesterone receptor	Rattus norvegicus	138-159
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	9,10-Dimethyl-1,2-benzanthracene	32-36	progesterone receptor	Rattus norvegicus	0-22
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	9,10-Dimethyl-1,2-benzanthracene	32-36	progesterone receptor	Rattus norvegicus	24-27
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	Tamoxifen	78-87	progesterone receptor	Rattus norvegicus	0-22
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	Tamoxifen	78-87	progesterone receptor	Rattus norvegicus	24-27
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	Bromocriptine	117-130	progesterone receptor	Rattus norvegicus	0-22
6323151-6	1983	Progesterone receptors (PgR) in DMBA-induced mammary tumors were abolished by tamoxifen and significantly reduced by bromocriptine.	Bromocriptine	117-130	progesterone receptor	Rattus norvegicus	24-27
6323151-7	1983	Combined administration of ovine PRL with tamoxifen attenuated the inhibition of PgR induced by tamoxifen alone, while ER remained undetectable.	Tamoxifen	42-51	progesterone receptor	Rattus norvegicus	81-84
6323151-7	1983	Combined administration of ovine PRL with tamoxifen attenuated the inhibition of PgR induced by tamoxifen alone, while ER remained undetectable.	Tamoxifen	96-105	progesterone receptor	Rattus norvegicus	81-84
6627946-3	1983	RU-486 likely antagonizes progesterone action on the uterus progesterone receptor.	Mifepristone	0-6	progesterone receptor	Rattus norvegicus	60-81
6627946-8	1983	The relative abilities of the various tested steroids to bind to the rat ovary progesterone receptor were: RU-486 greater than or equal to R5020 greater than progesterone.	Steroids	45-53	progesterone receptor	Rattus norvegicus	79-100
6627946-8	1983	The relative abilities of the various tested steroids to bind to the rat ovary progesterone receptor were: RU-486 greater than or equal to R5020 greater than progesterone.	Mifepristone	107-113	progesterone receptor	Rattus norvegicus	79-100
6625605-4	1983	Recovery of progesterone receptor binding was improved by prelabeling with [3H]R5020, by adding 1.5 mM ethylene glycol bis(beta-aminoethylether)N,N"-tetraacetic acid (EGTA) to all buffers, and at high tissue concentrations.	Tritium	76-78	progesterone receptor	Rattus norvegicus	12-33
6625605-4	1983	Recovery of progesterone receptor binding was improved by prelabeling with [3H]R5020, by adding 1.5 mM ethylene glycol bis(beta-aminoethylether)N,N"-tetraacetic acid (EGTA) to all buffers, and at high tissue concentrations.	Egtazic Acid	103-165	progesterone receptor	Rattus norvegicus	12-33
6625605-4	1983	Recovery of progesterone receptor binding was improved by prelabeling with [3H]R5020, by adding 1.5 mM ethylene glycol bis(beta-aminoethylether)N,N"-tetraacetic acid (EGTA) to all buffers, and at high tissue concentrations.	Egtazic Acid	167-171	progesterone receptor	Rattus norvegicus	12-33
6411477-2	1983	DMBA-induced rat mammary tumors were subjected to a treatment of 20 Gy and the ER and PgR concentrations were determined at different time intervals after irradiation.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	0-4	progesterone receptor	Rattus norvegicus	86-89
6574454-1	1983	Antibodies to molybdate-stabilized chicken oviduct progesterone receptor were raised in a Wistar rat and detected by interaction with homogeneous radioiodinated progesterone receptor.	molybdate	14-23	progesterone receptor	Rattus norvegicus	161-182
6833286-0	1983	Action of glycerol and sodium molybdate in stabilization of the progesterone receptor from rat trophoblast.	Glycerol	10-18	progesterone receptor	Rattus norvegicus	64-85
6833286-0	1983	Action of glycerol and sodium molybdate in stabilization of the progesterone receptor from rat trophoblast.	sodium molybdate(VI)	23-39	progesterone receptor	Rattus norvegicus	64-85
6833286-1	1983	This study compares the stabilizing effects of glycerol and sodium molybdate on the progesterone receptor in vitro.	Glycerol	47-55	progesterone receptor	Rattus norvegicus	84-105
6833286-1	1983	This study compares the stabilizing effects of glycerol and sodium molybdate on the progesterone receptor in vitro.	sodium molybdate(VI)	60-76	progesterone receptor	Rattus norvegicus	84-105
6341612-3	1983	Within 72 h following treatment with estrogen, diethylstilbestrol (DES), or C1628, changes in the levels of estrogen receptor (ER) and progesterone receptor (PgR) were evident in both uterine and mammary tumor tissue.	Diethylstilbestrol	47-65	progesterone receptor	Rattus norvegicus	135-156
6885133-0	1983	Metallic copper decreases rat uterine progesterone receptor content and progesterone binding.	metallic	0-8	progesterone receptor	Rattus norvegicus	38-59
6885133-0	1983	Metallic copper decreases rat uterine progesterone receptor content and progesterone binding.	Copper	9-15	progesterone receptor	Rattus norvegicus	38-59
6341612-3	1983	Within 72 h following treatment with estrogen, diethylstilbestrol (DES), or C1628, changes in the levels of estrogen receptor (ER) and progesterone receptor (PgR) were evident in both uterine and mammary tumor tissue.	Diethylstilbestrol	47-65	progesterone receptor	Rattus norvegicus	158-161
6341612-3	1983	Within 72 h following treatment with estrogen, diethylstilbestrol (DES), or C1628, changes in the levels of estrogen receptor (ER) and progesterone receptor (PgR) were evident in both uterine and mammary tumor tissue.	Diethylstilbestrol	67-70	progesterone receptor	Rattus norvegicus	135-156
6341612-3	1983	Within 72 h following treatment with estrogen, diethylstilbestrol (DES), or C1628, changes in the levels of estrogen receptor (ER) and progesterone receptor (PgR) were evident in both uterine and mammary tumor tissue.	Diethylstilbestrol	67-70	progesterone receptor	Rattus norvegicus	158-161
6341612-8	1983	The cytosolic PgR was consistently high in tumors of control rats (42.99 +/- 11.9 fmol/mg protein) and in castrated rats treated with high doses of DES or C1628 (DES, 55.15 +/- 27.0; C1628, 65.07 +/- 9.8 protein).	Diethylstilbestrol	148-151	progesterone receptor	Rattus norvegicus	14-17
7078152-0	1982	Steroid-binding specificity of the progesterone receptor from rat placenta.	Steroids	0-7	progesterone receptor	Rattus norvegicus	35-56
6890442-0	1982	Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol.	Tamoxifen	82-99	progesterone receptor	Rattus norvegicus	26-47
6890442-0	1982	Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol.	LY 117018	101-109	progesterone receptor	Rattus norvegicus	26-47
6890442-0	1982	Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol.	Estradiol	115-124	progesterone receptor	Rattus norvegicus	26-47
6955558-8	1982	This fact plus the finding that testosterone only partially blocked the estradiol-induced increase in uterine progesterone receptor levels suggested stimulation of different cell types by testosterone and estradiol.	Testosterone	32-44	progesterone receptor	Rattus norvegicus	110-131
6955558-8	1982	This fact plus the finding that testosterone only partially blocked the estradiol-induced increase in uterine progesterone receptor levels suggested stimulation of different cell types by testosterone and estradiol.	Estradiol	72-81	progesterone receptor	Rattus norvegicus	110-131
6955558-8	1982	This fact plus the finding that testosterone only partially blocked the estradiol-induced increase in uterine progesterone receptor levels suggested stimulation of different cell types by testosterone and estradiol.	Testosterone	188-200	progesterone receptor	Rattus norvegicus	110-131
6955558-8	1982	This fact plus the finding that testosterone only partially blocked the estradiol-induced increase in uterine progesterone receptor levels suggested stimulation of different cell types by testosterone and estradiol.	Estradiol	205-214	progesterone receptor	Rattus norvegicus	110-131
6181577-4	1982	The number of binding sites of ER and PR was estimated by exchange assay using dextran charcoal.	dextran charcoal	79-95	progesterone receptor	Rattus norvegicus	38-40
6832299-2	1983	However, expression of PA at certain periods, when PgR was undetectable suggests, that the extent of availability of both estradiol and progesterone at target sites may act as controlling factors in synthesis of one protein over another.	Protactinium	23-25	progesterone receptor	Rattus norvegicus	51-54
6955558-2	1982	Progesterone receptor levels were barely detectable in tumors grown in male WF rats but were increased after castration or administration of 17 beta-estradiol.	Estradiol	141-158	progesterone receptor	Rattus norvegicus	0-21
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Testosterone	44-56	progesterone receptor	Rattus norvegicus	91-112
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Testosterone	44-56	progesterone receptor	Rattus norvegicus	218-239
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Dihydrotestosterone	61-80	progesterone receptor	Rattus norvegicus	91-112
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Dihydrotestosterone	61-80	progesterone receptor	Rattus norvegicus	218-239
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Testosterone	68-80	progesterone receptor	Rattus norvegicus	91-112
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Testosterone	68-80	progesterone receptor	Rattus norvegicus	218-239
6955558-4	1982	In tumors grown in intact female rats, both testosterone and dihydrotestosterone decreased progesterone receptor levels in a dose-dependent manner, and testosterone completely blocked the estradiol-induced increase in progesterone receptor levels in tumors from ovariectomized rats.	Estradiol	188-197	progesterone receptor	Rattus norvegicus	218-239
7078152-1	1982	We have attempted to delineate some salient features of the progesterone binding site of the cytosol progesterone receptor (Rp) in rat placenta by studying the binding profile of various chemical modifications of the progesterone molecule (P).	Progesterone	60-72	progesterone receptor	Rattus norvegicus	101-122
7341237-3	1981	Progesterone can be covalently attached to the partially purified progesterone receptor and to uteroglobin, and comigrates with the binding proteins upon electrophoresis in polyacrylamide gels containing sodium dodecyl sulfate.	polyacrylamide	173-187	progesterone receptor	Rattus norvegicus	66-87
7053987-0	1982	Differential stimulation by 17 beta-estradiol and synthetic estrogens of progesterone-receptor and of translocation of estrogen-receptor in rat pituitary and uterus.	Estradiol	28-45	progesterone receptor	Rattus norvegicus	73-94
7053987-6	1982	On the other hand, only 208% and 225% stimulation, respectively, of progesterone-receptor was observed in the uterus after treatment with the synthetic estrogens DM-EE2 and DB-EE2.	dm-ee2	162-168	progesterone receptor	Rattus norvegicus	68-89
7053987-6	1982	On the other hand, only 208% and 225% stimulation, respectively, of progesterone-receptor was observed in the uterus after treatment with the synthetic estrogens DM-EE2 and DB-EE2.	db-ee2	173-179	progesterone receptor	Rattus norvegicus	68-89
7341237-3	1981	Progesterone can be covalently attached to the partially purified progesterone receptor and to uteroglobin, and comigrates with the binding proteins upon electrophoresis in polyacrylamide gels containing sodium dodecyl sulfate.	Sodium Dodecyl Sulfate	204-226	progesterone receptor	Rattus norvegicus	66-87
6894653-8	1981	The latter modifications are likely to increase the specificity of androstane derivatives for receptors other than androgen binding proteins, such as the progesterone receptor.	androstane	67-77	progesterone receptor	Rattus norvegicus	154-175
6971219-5	1981	Progesterone receptor levels were stimulated in the pituitary by repeated injection of 17 beta-estradiol, DM-EE2 and DB-EE2 and to a smaller degree by tamoxifen.	dm-ee2	106-112	progesterone receptor	Rattus norvegicus	0-21
7459886-4	1981	Tamoxifen antagonized this effect of estrogen, although when administered by itself to ovariectomized rats it acted as an agonist, since progesterone receptor levels were induced.	Tamoxifen	0-9	progesterone receptor	Rattus norvegicus	137-158
7459886-6	1981	In uterus from the same animals, tamoxifen also showed both antagonist and agonist properties, although here too there was an apparent dissociation between effects on growth and progesterone receptor levels.	Tamoxifen	33-42	progesterone receptor	Rattus norvegicus	178-199
7459886-7	1981	We conclude from these experiments that: (a) the estrogen receptor complex may be acting at more than one site on the genome; and (b) regulation of progesterone receptor levels by estrogen (or tamoxifen) does not necessarily predict sensitivity of tumor growth to antiestrogens.	Tamoxifen	193-202	progesterone receptor	Rattus norvegicus	148-169
6971219-5	1981	Progesterone receptor levels were stimulated in the pituitary by repeated injection of 17 beta-estradiol, DM-EE2 and DB-EE2 and to a smaller degree by tamoxifen.	Estradiol	87-104	progesterone receptor	Rattus norvegicus	0-21
6971219-5	1981	Progesterone receptor levels were stimulated in the pituitary by repeated injection of 17 beta-estradiol, DM-EE2 and DB-EE2 and to a smaller degree by tamoxifen.	db-ee2	117-123	progesterone receptor	Rattus norvegicus	0-21
6971219-5	1981	Progesterone receptor levels were stimulated in the pituitary by repeated injection of 17 beta-estradiol, DM-EE2 and DB-EE2 and to a smaller degree by tamoxifen.	Tamoxifen	151-160	progesterone receptor	Rattus norvegicus	0-21
7388787-2	1980	The progesterone receptor was absent in 78% of prostate tumors grown in male Copenhagen X Fischer F1 rats but was induced in tumors taken from rats given injections of 25 microgram estradiol benzoate per kg for 10 days.	estradiol 3-benzoate	181-199	progesterone receptor	Rattus norvegicus	4-25
6780953-3	1981	Following DMBA administration to 102 animals, only 60% developed carcinomas of the breast, of which 59 and 50% were ER- an PgR-positive, respectively.	9,10-Dimethyl-1,2-benzanthracene	10-14	progesterone receptor	Rattus norvegicus	123-126
7191796-7	1980	Progesterone receptor synthesis was inhibited by cycloheximide.	Cycloheximide	49-62	progesterone receptor	Rattus norvegicus	0-21
7414049-0	1980	Estrogen-like effects of O,P"-DDT on the progesterone receptor of rat uterine cytosol.	o,p'-DDT	25-33	progesterone receptor	Rattus norvegicus	41-62
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	9,10-Dimethyl-1,2-benzanthracene	13-35	progesterone receptor	Rattus norvegicus	221-242
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	9,10-Dimethyl-1,2-benzanthracene	37-41	progesterone receptor	Rattus norvegicus	121-142
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	9,10-Dimethyl-1,2-benzanthracene	13-35	progesterone receptor	Rattus norvegicus	121-142
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	9,10-Dimethyl-1,2-benzanthracene	37-41	progesterone receptor	Rattus norvegicus	221-242
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	Tamoxifen	174-183	progesterone receptor	Rattus norvegicus	121-142
6775807-4	1980	In rats with dimethylbenzanthracene (DMBA)-induced rat mammary carcinomata, young tumors that are estrogen receptor- and progesterone receptor-rich respond more favorably to tamoxifen that do older estrogen receptor- and progesterone receptor-poor tumors.	Tamoxifen	174-183	progesterone receptor	Rattus norvegicus	221-242
761680-4	1979	Finally, danazol bound to the progesterone receptor of the rat uterus, but controversy continues as the whether danazol possesses progestational, antiprogestational, or no progestational effects.	Danazol	9-16	progesterone receptor	Rattus norvegicus	30-51
6996407-3	1980	In rat uterus a late oestrogenic effect, the synthesis of the progesterone receptor, induced by ethinyloestradiol, is shown to be inhibited by oestriol.	Ethinyl Estradiol	96-113	progesterone receptor	Rattus norvegicus	62-83
6996407-3	1980	In rat uterus a late oestrogenic effect, the synthesis of the progesterone receptor, induced by ethinyloestradiol, is shown to be inhibited by oestriol.	Estriol	143-151	progesterone receptor	Rattus norvegicus	62-83
93289-3	1979	When injected into immature rats, chlordecone translocates estrogen receptor sites to the uterine nucleus, increases uterine weight, and stimulates the synthesis of the progesterone receptor, an estrogen receptor-mediated process.	Chlordecone	34-45	progesterone receptor	Rattus norvegicus	169-190
574672-2	1979	This progesterone receptor was shown to be a thermolabile, saturable protein, which is specific for progestins (R5020 and progesterone), and elutes at the void volume of a Sephadex G-200 column.	sephadex	172-180	progesterone receptor	Rattus norvegicus	5-26
491598-0	1979	Effect of oestradiol benzoate, tamoxifen and monohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division.	estradiol 3-benzoate	10-29	progesterone receptor	Rattus norvegicus	90-111
491598-0	1979	Effect of oestradiol benzoate, tamoxifen and monohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division.	monohydroxytamoxifen	45-65	progesterone receptor	Rattus norvegicus	90-111
201053-1	1977	Daily injections of estradiol or the antiestrogen tamoxifen initially stimulate uterine weight increase and progesterone receptor synthesis, though continued tamoxifen fails to maintain the increased weight.	Estradiol	20-29	progesterone receptor	Rattus norvegicus	108-129
561151-0	1977	Binding of methyltrienolone (R1881) to a progesterone receptor-like component of human prostatic cytosol.	Metribolone	11-27	progesterone receptor	Rattus norvegicus	41-62
624886-1	1978	The synthetic progestogen R5020 (17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione) binds with high affinity (Ka = 8.8 X 10(8) l/mol at 0 degree C) to the progesterone receptor from rat uterine cytosol.	17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione	33-81	progesterone receptor	Rattus norvegicus	154-175
663958-5	1978	The 4S peak was eliminated by competition with unlabeled cortisol leaving a single 6S peak (progesterone receptor).	Hydrocortisone	57-65	progesterone receptor	Rattus norvegicus	92-113
201053-1	1977	Daily injections of estradiol or the antiestrogen tamoxifen initially stimulate uterine weight increase and progesterone receptor synthesis, though continued tamoxifen fails to maintain the increased weight.	Tamoxifen	50-59	progesterone receptor	Rattus norvegicus	108-129
33123315-0	2020	Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP+-Induced Toxicity via Progesterone Receptor Signaling.	puerarin	15-23	progesterone receptor	Rattus norvegicus	112-133
33901612-1	2021	Activation of progesterone receptor (PR) facilitates lordosis 36 to 48 hr after estradiol treatment, but induces concurrent inhibition (CI) when given with estradiol, or sequential inhibition (SI) when given subsequent to the faciliatory time interval.	Estradiol	80-89	progesterone receptor	Rattus norvegicus	14-35
33901612-1	2021	Activation of progesterone receptor (PR) facilitates lordosis 36 to 48 hr after estradiol treatment, but induces concurrent inhibition (CI) when given with estradiol, or sequential inhibition (SI) when given subsequent to the faciliatory time interval.	Estradiol	80-89	progesterone receptor	Rattus norvegicus	37-39
33901612-1	2021	Activation of progesterone receptor (PR) facilitates lordosis 36 to 48 hr after estradiol treatment, but induces concurrent inhibition (CI) when given with estradiol, or sequential inhibition (SI) when given subsequent to the faciliatory time interval.	Estradiol	156-165	progesterone receptor	Rattus norvegicus	14-35
33901612-1	2021	Activation of progesterone receptor (PR) facilitates lordosis 36 to 48 hr after estradiol treatment, but induces concurrent inhibition (CI) when given with estradiol, or sequential inhibition (SI) when given subsequent to the faciliatory time interval.	Estradiol	156-165	progesterone receptor	Rattus norvegicus	37-39
33974468-5	2021	RESULTS: The expressions of PR, PRA, and PRB protein were significantly increased in the eutopic endometrium after low-dose aspirin treatment, and the level of PRB mRNA was also increased while the ratio of PRA/PRB mRNA was decreased in the eutopic endometrium.	Aspirin	124-131	progesterone receptor	Rattus norvegicus	28-30
33987364-9	2021	Moreover, treatment with FA and ICA remarkably down-regulated the serum expression levels of LH, PRL, T, and E2, as well as the mRNA expression levels of ERalpha, PR, ERK1, and ERK2.	icariin	32-35	progesterone receptor	Rattus norvegicus	97-99
33987364-11	2021	Conclusions: Our outcomes revealed that FA and ICA might potentially inhibit ERalpha, PR, ERK1/2, and their phosphorylated proteins via the ERK signaling pathway, thus indicating a positive feedback control for the degree of breast hyperplasia.	icariin	47-50	progesterone receptor	Rattus norvegicus	86-88
33166560-4	2021	To assess the potential role of PR activity on the development of these connections and associated behavior, rats were treated daily from P1 to 7 with PR antagonist, RU486.	Mifepristone	166-171	progesterone receptor	Rattus norvegicus	151-153
33166560-5	2021	RU486 treatment increased the number of reelin-ir cells, suggesting an accumulation of reelin, implicating PR in the regulation of a principle developmental function of CR cells.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	107-109
33166560-6	2021	RU486 also altered the synaptic bouton marker, synaptophysin-ir, in a sex-specific manner, suggesting a role for PR activity in the development of perforant path innervation of the molecular layer (MOL).	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	113-115
33166560-9	2021	These findings reveal a novel role for PR in regulating CR cell function within the MOL, thereby altering development of DG connectivity and behavioral function.	Chromium	56-58	progesterone receptor	Rattus norvegicus	39-41
33123315-2	2020	Objectives: The present study was designed to determine whether botanical drug puerarin could exhibit neuroprotective and neurorestorative activities via PR signaling.	puerarin	79-87	progesterone receptor	Rattus norvegicus	154-156
33123315-10	2020	RU486 and PR-siRNA could inhibit the effect of puerarin.	puerarin	47-55	progesterone receptor	Rattus norvegicus	10-12
33123315-11	2020	Puerarin and progesterone could enhance the PR promoter.	puerarin	0-8	progesterone receptor	Rattus norvegicus	44-46
33123315-11	2020	Puerarin and progesterone could enhance the PR promoter.	Progesterone	13-25	progesterone receptor	Rattus norvegicus	44-46
33123315-12	2020	Conclusion: Puerarin attenuated MPTP- and MPP+-induced toxicity and potentiated neurite outgrowth via PR.	puerarin	12-20	progesterone receptor	Rattus norvegicus	102-104
32640336-6	2020	Both compounds increased the uterine ERalpha protein expression, with no differences at transcript level; and only Gly decreased PR mRNA expression.	Glycine	115-118	progesterone receptor	Rattus norvegicus	129-131
33112549-5	2020	RESULTS: Treatment with sirolimus alone lowered expressions of ER and PgR of breast cancer and reduced tumor size.	Sirolimus	24-33	progesterone receptor	Rattus norvegicus	70-73
32574858-8	2020	The CS/Exos transplantation potently induced (i) endometrium regeneration, (ii) collagen remodeling, (iii) increased the expression of the estrogen receptor alpha/progesterone receptor, and (iv) restored fertility.	Cesium	4-6	progesterone receptor	Rattus norvegicus	163-184
32670203-3	2020	Estradiol from developing ovarian follicles acts on ERalpha-expressing kisspeptin neurons in the rostral periventricular region of the third ventricle (RP3V) to induce PGR expression, and kisspeptin release.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	168-171
32618512-0	2020	Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP1 formation.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	93-114
32618512-6	2020	At last, rats were intraperitoneally injected with progesterone receptor antagonist RU486, then the expression of eNOS and vasodilation function in thoracic aorta and mesenteric artery were measured.	Mifepristone	84-89	progesterone receptor	Rattus norvegicus	51-72
32618512-10	2020	We also observed that progesterone receptor antagonist RU486 reduced eNOS expression and impaired vasodilation in rats.	Mifepristone	55-60	progesterone receptor	Rattus norvegicus	22-43
31452481-9	2019	In addition, expression levels of the oestrogen receptor Ealpha/beta (ERalpha, ERbeta) and progesterone receptor (PR) detected by western blot and enzyme-linked immunosorbent assay (ELISA) were higher in the ADSCs group than in the PBS group.	pbs	232-235	progesterone receptor	Rattus norvegicus	91-112
31901732-8	2020	Moreover, LPS-induced increases in the expression levels of TNF-alpha, IL-1beta and pGR-Ser246 in these brain regions were reduced when the rats were treated with SP600125.	pyrazolanthrone	163-171	progesterone receptor	Rattus norvegicus	84-87
30393115-9	2019	Interestingly, both L and EU from HCB-treated rats exhibited higher estrogen receptor alpha (ERalpha) (immunohistochemistry) and metalloproteases (MMP)-2 and -9 levels (Western Blot), as well as lower progesterone receptor (PR) expression (immunohistochemistry) than in control rats.	Hexachlorobenzene	34-37	progesterone receptor	Rattus norvegicus	201-222
31213288-2	2019	The progestin Nestorone  (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor.	ST 1435	26-45	progesterone receptor	Rattus norvegicus	168-189
30321495-2	2019	The progestin Nestorone  (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor.	ST 1435	14-23	progesterone receptor	Rattus norvegicus	168-189
31568208-6	2019	We found that baicalin could reduce the neurological deficits, infarct volume caused by middle cerebral artery occlusion, increase the expression of NeuN, GFAP, and progesterone receptor in ischemic penumbra and increase the expression of progesterone and adrenocorticotropic hormone level in serum.	baicalin	14-22	progesterone receptor	Rattus norvegicus	165-186
30393115-9	2019	Interestingly, both L and EU from HCB-treated rats exhibited higher estrogen receptor alpha (ERalpha) (immunohistochemistry) and metalloproteases (MMP)-2 and -9 levels (Western Blot), as well as lower progesterone receptor (PR) expression (immunohistochemistry) than in control rats.	Hexachlorobenzene	34-37	progesterone receptor	Rattus norvegicus	224-226
31330414-0	2019	18F-labeled ethisterone derivative for progesterone receptor targeted PET imaging of breast cancer.	Ethisterone	12-23	progesterone receptor	Rattus norvegicus	39-60
31330414-1	2019	PURPOSE: A novel radiolabeled probe 1-(17-[18F]fluoro-3,6,9,12,15-pentaoxaheptadecyl-1H-1,2,3-triazole testosterone ([18F]FPTT) was synthesized and evaluated for PET imaging of progesterone receptor (PR)-positive breast cancer.	1-(17-[18f]fluoro-3,6,9,12,15-pentaoxaheptadecyl-1h-1,2,3-triazole testosterone	36-115	progesterone receptor	Rattus norvegicus	177-198
31330414-1	2019	PURPOSE: A novel radiolabeled probe 1-(17-[18F]fluoro-3,6,9,12,15-pentaoxaheptadecyl-1H-1,2,3-triazole testosterone ([18F]FPTT) was synthesized and evaluated for PET imaging of progesterone receptor (PR)-positive breast cancer.	1-(17-[18f]fluoro-3,6,9,12,15-pentaoxaheptadecyl-1h-1,2,3-triazole testosterone	36-115	progesterone receptor	Rattus norvegicus	200-202
31330414-2	2019	METHODS: The ethinyl group of ethisterone, a PR targeting pharmacophore, was coupled with azide modified PEG-OTs by click chemistry to obtain the labeling precursor.	Ethisterone	30-41	progesterone receptor	Rattus norvegicus	45-47
31330414-2	2019	METHODS: The ethinyl group of ethisterone, a PR targeting pharmacophore, was coupled with azide modified PEG-OTs by click chemistry to obtain the labeling precursor.	Azides	90-95	progesterone receptor	Rattus norvegicus	45-47
31330414-2	2019	METHODS: The ethinyl group of ethisterone, a PR targeting pharmacophore, was coupled with azide modified PEG-OTs by click chemistry to obtain the labeling precursor.	Polyethylene Glycols	105-108	progesterone receptor	Rattus norvegicus	45-47
31330414-13	2019	CONCLUSION: A novel [18F]FPTT probe based on ethisterone modification could be a potential diagnostic agent for PR-positive breast cancer.	Ethisterone	45-56	progesterone receptor	Rattus norvegicus	112-114
29535146-4	2018	In vivo and in vitro studies of the effects of metformin on the regulation of the uterine P4 signaling pathway under PCOS conditions showed that metformin directly inhibits the expression of PGR and ER along with the regulation of several genes that are targeted dependently or independently of PGR-mediated uterine implantation.	Metformin	145-154	progesterone receptor	Rattus norvegicus	191-194
30069875-6	2018	However, virtually all PR cells co-expressed the calcium binding protein, calretinin, and the glycoprotein, reelin, both reliable markers for Cajal-Retzius neurons, a transient population of developmentally critical pioneer neurons that guide synaptogenesis of perforant path afferents and histogenesis of the dentate gyrus.	Calcium	49-56	progesterone receptor	Rattus norvegicus	23-25
29535146-4	2018	In vivo and in vitro studies of the effects of metformin on the regulation of the uterine P4 signaling pathway under PCOS conditions showed that metformin directly inhibits the expression of PGR and ER along with the regulation of several genes that are targeted dependently or independently of PGR-mediated uterine implantation.	Metformin	145-154	progesterone receptor	Rattus norvegicus	295-298
29535146-5	2018	Functionally, metformin treatment corrected the abnormal expression of cell-specific PGR and ER and some PGR-target genes in PCOS-like rats with implantation.	Metformin	14-23	progesterone receptor	Rattus norvegicus	85-88
29535146-5	2018	Functionally, metformin treatment corrected the abnormal expression of cell-specific PGR and ER and some PGR-target genes in PCOS-like rats with implantation.	Metformin	14-23	progesterone receptor	Rattus norvegicus	105-108
29535146-6	2018	Additionally, we documented how metformin contributes to the regulation of the PGR-associated MAPK/ERK/p38 signaling pathway in the PCOS-like rat uterus.	Metformin	32-41	progesterone receptor	Rattus norvegicus	79-82
29037132-5	2017	We found that applying DDT results in altered expression of microRNAs-221, -222, -205, -126a, and -429, their target genes (Pten, Dicer1), as well as genes involved in hormonal carcinogenesis (Esr1, Pgr, Ccnd1, Cyp19a1).	DDT	23-26	progesterone receptor	Rattus norvegicus	199-202
28882474-0	2017	Postpartum inhibition of ovarian steroid action increases aspects of maternal caregiving and reduces medial preoptic area progesterone receptor expression in female rats.	Steroids	33-40	progesterone receptor	Rattus norvegicus	122-143
28882474-7	2017	In a second study, gonadally intact dams were given the PR antagonist, RU 486, and were found to display more kyphosis and less supine nursing compared to controls.	Mifepristone	71-77	progesterone receptor	Rattus norvegicus	56-58
29435821-0	2018	7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERalpha, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway.	daphnetin	0-21	progesterone receptor	Rattus norvegicus	111-113
29435821-0	2018	7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERalpha, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway.	9,10-Dimethyl-1,2-benzanthracene	52-56	progesterone receptor	Rattus norvegicus	111-113
29435821-7	2018	DMBA induces large tumor burden and histological alterations in mammary gland with a subsequent increase in ERalpha, PR, EGFR, IGF1R, Ki-67, proliferating cell nuclear antigen (PCNA ), cytokines, and chemokine expressions.	9,10-Dimethyl-1,2-benzanthracene	0-4	progesterone receptor	Rattus norvegicus	117-119
29127312-7	2017	Progesterone receptor antagonist RU-486 were further applied.	Mifepristone	33-39	progesterone receptor	Rattus norvegicus	0-21
29127312-11	2017	Moreover, progesterone receptor antagonist RU-486 partially reversed the effects of P4 on NF-kappaB pathway.	Mifepristone	43-49	progesterone receptor	Rattus norvegicus	10-31
29037132-7	2017	The data suggest that epigenetic effects induced by DDT as a potential carcinogen may be based on at least two mechanisms: (i) activation of ERalpha followed by altered expression of the target genes encoding receptor Pgr and Ccnd1 as well as impaired expression of Cyp19a1, affecting, thereby, cell hormone balance; and (ii) changed expression of microRNAs resulting in impaired expression of related target genes including reduced level of Cyp19a1 mRNA.	DDT	52-55	progesterone receptor	Rattus norvegicus	218-221
28850381-8	2017	tGR and pGR protein levels in the SDH however, significantly increased on the ipsilateral side of SNL compared to the contralateral side and to naive tissue.	sdh	34-37	progesterone receptor	Rattus norvegicus	8-11
28414589-8	2017	CONCLUSION: The blocking of progesterone receptor on these cells by mifepristone restored IDO expression levels and may constitute evidence of the participation of this hormone through a direct route in these cells.	Mifepristone	68-80	progesterone receptor	Rattus norvegicus	28-49
28260098-6	2017	The downregulated DEGs were highly enriched in female gonad development [e.g. progesterone receptor (Pgr)], and the steroid biosynthesis pathway.	Steroids	116-123	progesterone receptor	Rattus norvegicus	78-99
28387824-7	2017	Kp-10 also reduced dopamine levels in the ME of OVX+EP rats, an effect blocked by the progesterone receptor (PR) antagonist RU486.	Mifepristone	124-129	progesterone receptor	Rattus norvegicus	86-107
28387824-7	2017	Kp-10 also reduced dopamine levels in the ME of OVX+EP rats, an effect blocked by the progesterone receptor (PR) antagonist RU486.	Mifepristone	124-129	progesterone receptor	Rattus norvegicus	109-111
28285967-2	2017	This study aimed to evaluate the immunoexpression of the prognostic factors estrogen receptor alpha (ERalpha), progesterone receptor (PR) and Ki-67, in MNU and DMBA-induced rat mammary tumors, in order to know the model that best suits to woman breast cancer.	Methylnitrosourea	152-155	progesterone receptor	Rattus norvegicus	111-132
28285967-2	2017	This study aimed to evaluate the immunoexpression of the prognostic factors estrogen receptor alpha (ERalpha), progesterone receptor (PR) and Ki-67, in MNU and DMBA-induced rat mammary tumors, in order to know the model that best suits to woman breast cancer.	Methylnitrosourea	152-155	progesterone receptor	Rattus norvegicus	134-136
28285967-8	2017	All MNU and DMBA-induced mammary carcinomas were ER+/PR+, with a higher expression of ERalpha when compared with PR.	Methylnitrosourea	4-7	progesterone receptor	Rattus norvegicus	53-55
28285967-8	2017	All MNU and DMBA-induced mammary carcinomas were ER+/PR+, with a higher expression of ERalpha when compared with PR.	9,10-Dimethyl-1,2-benzanthracene	12-16	progesterone receptor	Rattus norvegicus	53-55
28285967-8	2017	All MNU and DMBA-induced mammary carcinomas were ER+/PR+, with a higher expression of ERalpha when compared with PR.	9,10-Dimethyl-1,2-benzanthracene	12-16	progesterone receptor	Rattus norvegicus	113-115
28285967-9	2017	Tumors" weight, the expression of ERalpha, PR, Ki-67 PI and MAI were higher in MNU-induced mammary carcinomas when compared with the DMBA-induced ones.	Methylnitrosourea	79-82	progesterone receptor	Rattus norvegicus	43-45
28285967-12	2017	In this way, the use of the rat model of MNU-induced mammary tumors is advised in experimental protocols aiming to study more aggressive mammary tumors within the group of double-positive mammary tumors (ER+/PR+).	Methylnitrosourea	41-44	progesterone receptor	Rattus norvegicus	208-210
28260098-6	2017	The downregulated DEGs were highly enriched in female gonad development [e.g. progesterone receptor (Pgr)], and the steroid biosynthesis pathway.	Steroids	116-123	progesterone receptor	Rattus norvegicus	101-104
26923738-4	2016	ATR blocked ovulation and prevented expression of epiregulin and progesterone receptor mRNA in hCG-treated animals.	DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE	95-98	progesterone receptor	Rattus norvegicus	65-86
27389922-7	2016	Pretreatment with mifepristone, a progesterone receptor antagonist and hydroxyflutamid, an androgen receptor antagonist significantly diminished the neuroprotective effects of progesterone and testosterone, respectively.	Mifepristone	18-30	progesterone receptor	Rattus norvegicus	34-55
27389922-7	2016	Pretreatment with mifepristone, a progesterone receptor antagonist and hydroxyflutamid, an androgen receptor antagonist significantly diminished the neuroprotective effects of progesterone and testosterone, respectively.	Testosterone	193-205	progesterone receptor	Rattus norvegicus	34-55
27389922-10	2016	Taken together, progesterone protects neurons via progesterone receptor-dependent genomic pathway, and allopregnanolone is involved in progesterone-mediated neuroprotection.	Progesterone	16-28	progesterone receptor	Rattus norvegicus	50-71
27373230-10	2016	Alcohol-exposed offspring also tended to develop more progesterone receptor (PR)-positive tumors.	Alcohols	0-7	progesterone receptor	Rattus norvegicus	54-75
27373230-10	2016	Alcohol-exposed offspring also tended to develop more progesterone receptor (PR)-positive tumors.	Alcohols	0-7	progesterone receptor	Rattus norvegicus	77-79
27986121-3	2016	METHODS: Eight weeks after the implantation of U87 cells in the cerebral cortex, we administered phosphorothioated antisense oligodeoxynucleotides (ODNs) to silence the expression of PR.	phosphorothioated	97-114	progesterone receptor	Rattus norvegicus	183-185
27986121-3	2016	METHODS: Eight weeks after the implantation of U87 cells in the cerebral cortex, we administered phosphorothioated antisense oligodeoxynucleotides (ODNs) to silence the expression of PR.	Oligodeoxyribonucleotides	125-146	progesterone receptor	Rattus norvegicus	183-185
27035990-3	2016	Characterization of rats with a null mutation at the Pgr locus has forced a reexamination of the role of progesterone in the regulation of the female reproductive cycle.	Progesterone	105-117	progesterone receptor	Rattus norvegicus	53-56
26852374-6	2016	Based on the observed ER and PgR positivity and HER2 negativity within these tumors, MNU-induced mammary adenocarcinomas in female rats appear to be hormonally dependent, similar to human luminal A type breast cancer.	Methylnitrosourea	85-88	progesterone receptor	Rattus norvegicus	29-32
26165333-4	2015	In the current study, the estrogenic effect of 2-ME on CaBP-9k, ERalpha, and progesterone receptor (PR) mRNA levels in the absence and presence of E2 and progesterone (P4) in in vivo and in vitro models was examined.	2-Methoxyestradiol	47-51	progesterone receptor	Rattus norvegicus	77-98
25168884-1	2015	Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-norprogesterone, is an orally active drug with a strong affinity for the progesterone receptor.	nomegestrol acetate	0-19	progesterone receptor	Rattus norvegicus	142-163
25168884-1	2015	Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-norprogesterone, is an orally active drug with a strong affinity for the progesterone receptor.	nomegestrol acetate	21-26	progesterone receptor	Rattus norvegicus	142-163
25168884-1	2015	Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-norprogesterone, is an orally active drug with a strong affinity for the progesterone receptor.	19-norprogesterone	66-84	progesterone receptor	Rattus norvegicus	142-163
26597778-0	2016	Induction and subcellular redistribution of progesterone receptor A and B by tamoxifen in the hypothalamic ventromedial neurons of young adult female Wistar rats.	Tamoxifen	77-86	progesterone receptor	Rattus norvegicus	44-65
26597778-2	2016	We examined the agonistic and antagonistic actions of tamoxifen in this nucleus by analyzing its effects on the total number of PR-immunoreactive neurons, PR mRNA and protein levels, and subcellular location of PRs in ovariectomized Wistar rats.	Tamoxifen	54-63	progesterone receptor	Rattus norvegicus	128-130
26597778-3	2016	The results show that tamoxifen has no agonistic action in the number of PR-immunoreactive neurons, but increases PR expression and labeling in the nucleus and cytoplasm of VMNvl neurons that constitutively express PRs.	Tamoxifen	22-31	progesterone receptor	Rattus norvegicus	114-116
26597778-4	2016	As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein.	Tamoxifen	18-27	progesterone receptor	Rattus norvegicus	98-100
26597778-4	2016	As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein.	Tamoxifen	18-27	progesterone receptor	Rattus norvegicus	131-133
26597778-4	2016	As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein.	Estradiol	52-61	progesterone receptor	Rattus norvegicus	98-100
26597778-4	2016	As an antagonist, tamoxifen partially inhibited the estradiol-dependent increase in the number of PR-immunoreactive neurons and in PR mRNA and protein levels, without interfering with the subcellular location of the protein.	Estradiol	52-61	progesterone receptor	Rattus norvegicus	131-133
26597778-5	2016	We suggest that tamoxifen influence on PR expression in the VMNvl critically depends on the presence or absence of estradiol.	Tamoxifen	16-25	progesterone receptor	Rattus norvegicus	39-41
26597778-5	2016	We suggest that tamoxifen influence on PR expression in the VMNvl critically depends on the presence or absence of estradiol.	Estradiol	115-124	progesterone receptor	Rattus norvegicus	39-41
26165333-7	2015	As inhibitors of ER and PR activity, ICI 182,780 and mifepristone (RU486) were observed to reverse the E2 or 2-ME mediated increase of CaBP-9k and Ltf mRNA expression.	Mifepristone	53-65	progesterone receptor	Rattus norvegicus	24-26
26165333-7	2015	As inhibitors of ER and PR activity, ICI 182,780 and mifepristone (RU486) were observed to reverse the E2 or 2-ME mediated increase of CaBP-9k and Ltf mRNA expression.	Mifepristone	67-72	progesterone receptor	Rattus norvegicus	24-26
26165333-7	2015	As inhibitors of ER and PR activity, ICI 182,780 and mifepristone (RU486) were observed to reverse the E2 or 2-ME mediated increase of CaBP-9k and Ltf mRNA expression.	2-Methoxyestradiol	109-113	progesterone receptor	Rattus norvegicus	24-26
26165333-8	2015	In addition, it was found that 2-ME significantly decreased the levels of ERalpha and increased PR transcripts.	2-Methoxyestradiol	31-35	progesterone receptor	Rattus norvegicus	96-98
26165333-9	2015	Consistent with the in vitro results, the mRNA levels revealed decreased ERalpha and increased PR in in vivo treatment of E2 and 2-ME.	Estradiol	122-124	progesterone receptor	Rattus norvegicus	95-97
26165333-9	2015	Consistent with the in vitro results, the mRNA levels revealed decreased ERalpha and increased PR in in vivo treatment of E2 and 2-ME.	2-Methoxyestradiol	129-133	progesterone receptor	Rattus norvegicus	95-97
26165333-10	2015	These findings demonstrate that the expression of estrogenic markers, CaBP-9k and Ltf, is regulated by 2-ME in in vitro and in vivo models, therefore, estrogenic activi-ties of 2-ME may be increased in females during the estrous cycle via the ER and/or PR-mediated signaling pathway.	2-Methoxyestradiol	103-107	progesterone receptor	Rattus norvegicus	253-255
26165333-10	2015	These findings demonstrate that the expression of estrogenic markers, CaBP-9k and Ltf, is regulated by 2-ME in in vitro and in vivo models, therefore, estrogenic activi-ties of 2-ME may be increased in females during the estrous cycle via the ER and/or PR-mediated signaling pathway.	2-Methoxyestradiol	177-181	progesterone receptor	Rattus norvegicus	253-255
26004213-2	2015	To identify ovulatory specific PGR-regulated genes, a preliminary microarray analysis was performed using rat granulosa cells treated with hCG +- RU486 (PGR antagonist).	Mifepristone	146-151	progesterone receptor	Rattus norvegicus	31-34
26190222-3	2015	RU486 was used to determine if a high dose and/or repeated treatment with EB enhanced proceptivity and reduced the response to mild stress through an intracellular progesterone receptor-mediated process.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	164-185
26190222-3	2015	RU486 was used to determine if a high dose and/or repeated treatment with EB enhanced proceptivity and reduced the response to mild stress through an intracellular progesterone receptor-mediated process.	estradiol 3-benzoate	74-76	progesterone receptor	Rattus norvegicus	164-185
26004213-2	2015	To identify ovulatory specific PGR-regulated genes, a preliminary microarray analysis was performed using rat granulosa cells treated with hCG +- RU486 (PGR antagonist).	Mifepristone	146-151	progesterone receptor	Rattus norvegicus	153-156
26004213-16	2015	P4/PGR mediates the LH-induced increase in Xlr5c-like mRNA.	Luteinizing Hormone	20-22	progesterone receptor	Rattus norvegicus	3-6
24738581-3	2014	From this effort, (R)-14c was identified as a potent nonsteroidal MR antagonist (IC50 = 4.5 nM) with higher than 500-fold selectivity versus PR and other related nuclear hormone receptors, with improved solubility as compared to 2 and pharmacokinetic properties suitable for oral administration.	(r)-14c	18-25	progesterone receptor	Rattus norvegicus	141-143
25926689-2	2015	This inhibitory action of FSH involves a decrease in the stimulatory effect of gonadotrope progesterone receptor (PR) activation, in a ligand-dependent (progesterone) and -independent (GNRH) manner.	Progesterone	91-103	progesterone receptor	Rattus norvegicus	114-116
25926689-3	2015	PR activation and action are mandatory for LH surge, and are dependent on the phosphorylation of serine (Ser) residues.	Serine	97-103	progesterone receptor	Rattus norvegicus	0-2
25926689-3	2015	PR activation and action are mandatory for LH surge, and are dependent on the phosphorylation of serine (Ser) residues.	Serine	105-108	progesterone receptor	Rattus norvegicus	0-2
25897495-3	2015	Here we describe a suppressive interaction between progesterone receptor (onapristone) and estrogen receptor (ICI182780) antagonists and their relation to a rescue phenomenon with concomitant regulation of Hand2, Bmp2 and p-ERK1/2 during the early decidualization steps.	onapristone	74-85	progesterone receptor	Rattus norvegicus	51-72
25897495-5	2015	We found that suppression of progesterone receptor activity by onapristone treatment resulted in resorption of the implantation sites with concomitant decrease in progesterone and estrogen receptors, PCNA, KI67 antigen, DESMIN, CCND3, CX43, Prl8a2, and signaling players such as transcription factor Hand2, Bmp2 mRNAs and p-ERK1/2.	onapristone	63-74	progesterone receptor	Rattus norvegicus	29-50
25152521-1	2014	RU486 is a partial progesterone and estrogen receptor antagonist, functioning to actively silence progesterone receptor gene-associated transcription.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	98-119
25152521-6	2014	Changes in the Pgr gene expression level as a consequence of RU486 administration was evaluated using quantitative real-time reverse transcription polymerase chain reaction.	Mifepristone	61-66	progesterone receptor	Rattus norvegicus	15-18
25152521-7	2014	The progesterone receptor gene and protein expression was ubiquitously decreased throughout pregnancy as a direct consequence of RU486 administration.	Mifepristone	129-134	progesterone receptor	Rattus norvegicus	4-25
25972201-1	2015	It is well-known that indomethacin (the cyclooxygenase 1 & 2 inhibitor) and RU486 (or mifepristone, the progesterone receptor antagonist) block follicular rupture in rats.	Mifepristone	90-102	progesterone receptor	Rattus norvegicus	108-129
25616002-3	2015	In aged ad libitum-fed rats, a decrease in the level of total GR and GR phosphorylated at Ser(232) (pGR) was detected.	Serine	90-93	progesterone receptor	Rattus norvegicus	100-103
25486513-6	2015	Both doses of endosulfan increased the progesterone receptor (PR) expression, whereas the higher dose led additionally to an increase in estrogen receptor alpha (ERalpha).	Endosulfan	14-24	progesterone receptor	Rattus norvegicus	39-60
25486513-6	2015	Both doses of endosulfan increased the progesterone receptor (PR) expression, whereas the higher dose led additionally to an increase in estrogen receptor alpha (ERalpha).	Endosulfan	14-24	progesterone receptor	Rattus norvegicus	62-64
24071475-7	2013	In addition, fluoride exposure significantly increased Eralpha and PgR protein expression levels and LHR protein expression.	Fluorides	13-21	progesterone receptor	Rattus norvegicus	67-70
23353902-7	2013	In both females and males, FLU reversed the nuclear levels of GR and pGR246 without affecting CORT and GR mRNA levels.	Fluoxetine	27-30	progesterone receptor	Rattus norvegicus	69-72
23410115-4	2013	RESULTS: Exposure to genistein and/or vinclozolin resulted in a higher saccharin intake on postnatal day 25 (P < 0.05) linked to a higher number of pro-acinar cells (P < 0.01) and mRNA expression of progesterone receptor, growth factors and gustine (P < 0.01).	Genistein	21-30	progesterone receptor	Rattus norvegicus	205-226
23410115-4	2013	RESULTS: Exposure to genistein and/or vinclozolin resulted in a higher saccharin intake on postnatal day 25 (P < 0.05) linked to a higher number of pro-acinar cells (P < 0.01) and mRNA expression of progesterone receptor, growth factors and gustine (P < 0.01).	vinclozolin	38-49	progesterone receptor	Rattus norvegicus	205-226
23553368-0	2013	Tibolone induces serotonin, estrogen, and progesterone receptor expression but not contractile response to serotonin in the rat uterus.	tibolone	0-8	progesterone receptor	Rattus norvegicus	42-63
23046854-3	2013	One hour before allopregnanolone, rats were injected with the progesterone receptor antagonist, RU486 (11beta-(4-dimethylamino)phenyl-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one), or vehicle.	Mifepristone	96-101	progesterone receptor	Rattus norvegicus	62-83
23153933-3	2013	Two days later, rats were injected subcutaneously (sc) with the progesterone receptor antagonist, CDB4124 (17alpha-acetoxy-21-methoxy-11beta-[4-N,N-dimethyaminopheny]-19-norpregna-4,9-dione-3,20-dione) (60 mg/kg), or vehicle (20% DMSO+propylene glycol).	telapristone acetate	98-105	progesterone receptor	Rattus norvegicus	64-85
23079166-5	2013	Mifepristone, a specific antagonist of progesterone receptor, abolished progesterone"s effect on body mass, inguinal fat mass, and lipogenic enzyme genes expression in inguinal adipose tissue.	Mifepristone	0-12	progesterone receptor	Rattus norvegicus	39-60
23592144-1	2013	Asoprisnil, a member of the selective progesterone receptor modulators, exerts high progesterone receptor selectivity, endometrial targeted advantages and significant anti-implantation effect in rats.	asoprisnil	0-10	progesterone receptor	Rattus norvegicus	38-59
23592144-1	2013	Asoprisnil, a member of the selective progesterone receptor modulators, exerts high progesterone receptor selectivity, endometrial targeted advantages and significant anti-implantation effect in rats.	asoprisnil	0-10	progesterone receptor	Rattus norvegicus	84-105
23211298-0	2012	Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells.	bisphenol A	22-33	progesterone receptor	Rattus norvegicus	86-107
22811025-9	2012	The myometrial response to GEN was more pronounced than that of the luminal epithelium, which may be due to a non-uniform distribution of steroid receptors, in particular the progesterone receptor.	Genistein	27-30	progesterone receptor	Rattus norvegicus	175-196
23010621-2	2012	Several agents lacking affinity for the PR, such as 5beta-reduced progestins, GnRH or prostaglandin E(2) (PGE(2)) facilitate estrous behavior in ovariectomized (ovx), estrogen-primed rats yet their action is blocked by the antiprogestin RU486.	5beta	52-57	progesterone receptor	Rattus norvegicus	40-42
23010621-2	2012	Several agents lacking affinity for the PR, such as 5beta-reduced progestins, GnRH or prostaglandin E(2) (PGE(2)) facilitate estrous behavior in ovariectomized (ovx), estrogen-primed rats yet their action is blocked by the antiprogestin RU486.	Prostaglandins E	106-109	progesterone receptor	Rattus norvegicus	40-42
22634476-7	2012	RU 486, specific antagonist of progesterone receptor, abolished the effect of progesterone on the adipokine mRNA level in inguinal adipose tissue.	Mifepristone	0-6	progesterone receptor	Rattus norvegicus	31-52
22634476-12	2012	Our results suggest that depot- and sex-dependent responsiveness of adipose tissue to the pharmacological dose of progesterone is controlled by both circulating concentration of progesterone and the white adipose tissue progesterone receptor level.	Progesterone	114-126	progesterone receptor	Rattus norvegicus	220-241
23211298-0	2012	Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells.	Parabens	38-45	progesterone receptor	Rattus norvegicus	86-107
23211298-9	2012	Pre-treatment with ICI 182,780, a pure estrogen antagonist, significantly reversed BPA- and IBP-induced CaBP-9k and PR upregulation in GH3 cells.	bisphenol A	83-86	progesterone receptor	Rattus norvegicus	116-118
23211298-9	2012	Pre-treatment with ICI 182,780, a pure estrogen antagonist, significantly reversed BPA- and IBP-induced CaBP-9k and PR upregulation in GH3 cells.	isobutylparaben	92-95	progesterone receptor	Rattus norvegicus	116-118
22147012-0	2012	Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.	Estradiol	127-143	progesterone receptor	Rattus norvegicus	26-47
22326965-0	2012	Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups.	Nicotine	85-93	progesterone receptor	Rattus norvegicus	14-35
22326965-2	2012	Rats were treated with the PR antagonist mifepristone (daily oral gavage 40 mug/g/d) or vehicle between postnatal days 3 and 15.	Mifepristone	41-53	progesterone receptor	Rattus norvegicus	27-29
22127542-12	2012	Both, E(2) and cadmium induced C3 and PR expression, and this was antagonized by ZK191703.	Cadmium	15-22	progesterone receptor	Rattus norvegicus	38-40
22116802-9	2012	Regulation of Mmp10 in cultured rat granulosa cells revealed that the EGF inhibitor AG1478 and the progesterone receptor antagonist RU486 suppressed the induction of Mmp10 mRNA, whereas the prostaglandin inhibitor NS398 had no effect.	Mifepristone	132-137	progesterone receptor	Rattus norvegicus	99-120
22147012-0	2012	Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.	Estradiol	127-143	progesterone receptor	Rattus norvegicus	96-117
22147012-0	2012	Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.	Estradiol	127-143	progesterone receptor	Rattus norvegicus	70-73
22147012-0	2012	Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.	Progesterone	26-38	progesterone receptor	Rattus norvegicus	70-73
22147012-5	2012	Pgr was hormonally responsive only in CA1 pyramidal neurons, and the induction of Pgr by E2 was partly antagonized by P4 only on the 30-d schedule.	Estradiol	89-91	progesterone receptor	Rattus norvegicus	82-85
22147012-8	2012	In neuroprogenitor cells of the DG (immunopositive for bromodeoxyuridine and doublecortin), both Pgrmc1 and Pgr were detected.	Bromodeoxyuridine	55-72	progesterone receptor	Rattus norvegicus	97-100
21810236-8	2011	In addition, melatonin promoted differential regulation of the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and melatonin receptor (MTR) along the reproductive tissues.	Melatonin	13-22	progesterone receptor	Rattus norvegicus	87-108
22076563-10	2012	Expression of the progesterone receptor (PR) gene was similarly induced by combined treatment with OP and IBP.	isobutylparaben	106-109	progesterone receptor	Rattus norvegicus	18-39
22076563-10	2012	Expression of the progesterone receptor (PR) gene was similarly induced by combined treatment with OP and IBP.	isobutylparaben	106-109	progesterone receptor	Rattus norvegicus	41-43
22076563-14	2012	Taken together, these results indicate that combined exposure to OP and IBP has a synergistic effect on the induction of CaBP-9k and PR gene expression via an ER-dependent pathway in GH3 cells.	isobutylparaben	72-75	progesterone receptor	Rattus norvegicus	133-135
21945546-0	2011	Effects of RU486 in the expression of progesterone receptor isoforms in the hypothalamus and the preoptic area of the rat during postpartum estrus.	Mifepristone	11-16	progesterone receptor	Rattus norvegicus	38-59
21945546-3	2011	We studied the regulation of PR expression by its antagonist, RU486 in the hypothalamus and the preoptic area of the rat during postpartum estrus by Western blot.	Mifepristone	62-67	progesterone receptor	Rattus norvegicus	29-31
21740945-0	2011	Progesterone receptor isoforms differentially regulate the expression of tryptophan and tyrosine hydroxylase and glutamic acid decarboxylase in the rat hypothalamus.	Tryptophan	73-83	progesterone receptor	Rattus norvegicus	0-21
21810236-8	2011	In addition, melatonin promoted differential regulation of the estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and melatonin receptor (MTR) along the reproductive tissues.	Melatonin	13-22	progesterone receptor	Rattus norvegicus	110-112
21543556-1	2011	The recently discovered selective nonsteroidal progesterone receptor (PR) antagonist 4-[3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile (PF-02413873) was characterized in metabolism studies in vitro, in preclinical pharmacokinetics in rat and dog, and in an initial pharmacokinetic study in human volunteers.	4-(3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl)oxy-2,6-dimethylbenzonitrile	85-180	progesterone receptor	Rattus norvegicus	47-68
21543556-1	2011	The recently discovered selective nonsteroidal progesterone receptor (PR) antagonist 4-[3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile (PF-02413873) was characterized in metabolism studies in vitro, in preclinical pharmacokinetics in rat and dog, and in an initial pharmacokinetic study in human volunteers.	4-(3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl)oxy-2,6-dimethylbenzonitrile	85-180	progesterone receptor	Rattus norvegicus	70-72
21543556-1	2011	The recently discovered selective nonsteroidal progesterone receptor (PR) antagonist 4-[3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile (PF-02413873) was characterized in metabolism studies in vitro, in preclinical pharmacokinetics in rat and dog, and in an initial pharmacokinetic study in human volunteers.	4-(3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl)oxy-2,6-dimethylbenzonitrile	182-193	progesterone receptor	Rattus norvegicus	47-68
21543556-1	2011	The recently discovered selective nonsteroidal progesterone receptor (PR) antagonist 4-[3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy-2,6-dimethylbenzonitrile (PF-02413873) was characterized in metabolism studies in vitro, in preclinical pharmacokinetics in rat and dog, and in an initial pharmacokinetic study in human volunteers.	4-(3-cyclopropyl-1-(methylsulfonylmethyl)-5-methyl-1H-pyrazol-4-yl)oxy-2,6-dimethylbenzonitrile	182-193	progesterone receptor	Rattus norvegicus	70-72
21086199-0	2011	Involvement of rat gonadotrope progesterone receptor in the ovary-mediated inhibitory action of FSH on LH synthesis.	Luteinizing Hormone	103-105	progesterone receptor	Rattus norvegicus	31-52
21440892-3	2011	The effect is blocked by pretreatment with progesterone receptor (PR) antagonist, RU486.	Mifepristone	82-87	progesterone receptor	Rattus norvegicus	43-64
21440892-3	2011	The effect is blocked by pretreatment with progesterone receptor (PR) antagonist, RU486.	Mifepristone	82-87	progesterone receptor	Rattus norvegicus	66-68
21635894-15	2011	Finally, the progesterone receptor antagonist, RU486, attenuated progesterone"s protection against restraint.	Mifepristone	47-52	progesterone receptor	Rattus norvegicus	13-34
21086199-2	2011	A reduced gondadotrope progesterone receptor (PR) phosphorylation/activation is likely to be the main causative factor involved in GnSAF bioactivity on LH release.	Luteinizing Hormone	152-154	progesterone receptor	Rattus norvegicus	23-44
21086199-2	2011	A reduced gondadotrope progesterone receptor (PR) phosphorylation/activation is likely to be the main causative factor involved in GnSAF bioactivity on LH release.	Luteinizing Hormone	152-154	progesterone receptor	Rattus norvegicus	46-48
21086199-4	2011	Thus, the purpose of the present work was to evaluate the involvement of PR in the inhibitory effects of GnSAF on LH synthesis in cycling rats.	Luteinizing Hormone	114-116	progesterone receptor	Rattus norvegicus	73-75
21086199-7	2011	These results indicate that PR is involved in ovarian GnSAF effect on LH content probably at a post-transcriptional level.	Luteinizing Hormone	70-72	progesterone receptor	Rattus norvegicus	28-30
20950620-2	2011	Adult female rats were treated with the PR antagonist, RU486 (1.25 and 5 mg), 3 h after parturition and sexual behavior was evaluated throughout the first postpartum day.	Mifepristone	55-60	progesterone receptor	Rattus norvegicus	40-42
21473877-0	2011	Estrogen receptor alpha is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens.	Parabens	101-109	progesterone receptor	Rattus norvegicus	76-97
21473877-7	2011	In the GH3 cells, a large increase in PR mRNA and protein was observed in a concentration-dependent manner after parabens treatment that was effectively blocked in the presence of antagonist of 17beta-estradiol (fulvestrant).	Parabens	113-121	progesterone receptor	Rattus norvegicus	38-40
21473877-7	2011	In the GH3 cells, a large increase in PR mRNA and protein was observed in a concentration-dependent manner after parabens treatment that was effectively blocked in the presence of antagonist of 17beta-estradiol (fulvestrant).	Estradiol	194-210	progesterone receptor	Rattus norvegicus	38-40
21473877-9	2011	To confirm that ERalpha signaling is involved in parabens induction of CaBP-9k and PR mRNA and protein, we treated GH3 cells with an antiestrogen, fulvestrant, which blocked the paraben-induced upregulation of CaBP-9k and PR.	Parabens	49-57	progesterone receptor	Rattus norvegicus	83-85
21473877-9	2011	To confirm that ERalpha signaling is involved in parabens induction of CaBP-9k and PR mRNA and protein, we treated GH3 cells with an antiestrogen, fulvestrant, which blocked the paraben-induced upregulation of CaBP-9k and PR.	Parabens	49-56	progesterone receptor	Rattus norvegicus	83-85
21473877-9	2011	To confirm that ERalpha signaling is involved in parabens induction of CaBP-9k and PR mRNA and protein, we treated GH3 cells with an antiestrogen, fulvestrant, which blocked the paraben-induced upregulation of CaBP-9k and PR.	Parabens	49-56	progesterone receptor	Rattus norvegicus	222-224
21473877-10	2011	Taken together, these results indicate that CaBP-9k and PR is induced by parabens via the ER pathway in GH3 cell line.	Parabens	73-81	progesterone receptor	Rattus norvegicus	56-58
21248286-12	2011	Expression of progesterone receptor A (PGR) was induced in the presence of resveratrol.	Resveratrol	75-86	progesterone receptor	Rattus norvegicus	14-37
21248286-12	2011	Expression of progesterone receptor A (PGR) was induced in the presence of resveratrol.	Resveratrol	75-86	progesterone receptor	Rattus norvegicus	39-42
21248290-7	2011	Treatment with the progesterone antagonist onapristone and/or the estrogen antagonist faslodex reduced the extent of decidual tissue and downregulated the levels of PGR and ESR1.	onapristone	43-54	progesterone receptor	Rattus norvegicus	165-168
21248290-7	2011	Treatment with the progesterone antagonist onapristone and/or the estrogen antagonist faslodex reduced the extent of decidual tissue and downregulated the levels of PGR and ESR1.	Fulvestrant	86-94	progesterone receptor	Rattus norvegicus	165-168
20605140-11	2011	CONCLUSION(S): Our findings suggest that melatonin may attenuate proliferation in ovarian structures and increase the number of luteal bodies as well as the levels of progesterone receptor.	Melatonin	41-50	progesterone receptor	Rattus norvegicus	167-188
20699413-8	2010	Expression of vascular endothelial growth factor receptor-1, estrogen receptor alpha, and progesterone receptor was also lower in hyperplastic mammary tissue in N-EL-, N-ONE-, and MGA-treated animals.	Megestrol Acetate	180-183	progesterone receptor	Rattus norvegicus	90-111
24900294-0	2011	Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.	3-aryl indoles	6-20	progesterone receptor	Rattus norvegicus	24-45
24900294-1	2011	We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids.	3-aryl indoles	54-68	progesterone receptor	Rattus norvegicus	95-116
24900294-1	2011	We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids.	3-aryl indoles	54-68	progesterone receptor	Rattus norvegicus	118-120
20057162-4	2010	The mRNA expression of the progesterone receptor (PR) in the preoptic area (POA) hypothalamus was higher in the experimental groups than in the control group after ovariectomy and stimulation with estradiol benzoate.	estradiol 3-benzoate	197-215	progesterone receptor	Rattus norvegicus	27-48
19818377-1	2010	Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	37-58
19818377-1	2010	Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	60-63
19818377-1	2010	Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH.	Luteinizing Hormone	174-176	progesterone receptor	Rattus norvegicus	37-58
19818377-1	2010	Progesterone, acting via the nuclear progesterone receptor (PGR), reduces apoptosis in periovulatory granulosa cells, and is a likely mediator of the anti-atretic actions of LH.	Luteinizing Hormone	174-176	progesterone receptor	Rattus norvegicus	60-63
20057162-4	2010	The mRNA expression of the progesterone receptor (PR) in the preoptic area (POA) hypothalamus was higher in the experimental groups than in the control group after ovariectomy and stimulation with estradiol benzoate.	estradiol 3-benzoate	197-215	progesterone receptor	Rattus norvegicus	50-52
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	pyrrolidine	180-191	progesterone receptor	Rattus norvegicus	108-110
20453473-4	2010	In addition, pituitaries from AIS- and NIS-injected rats were incubated and studied for PR-dependent LH secretion parameters: LH-releasing hormone (LHRH)-stimulated LH secretion, progesterone-potentiated LHRH-stimulated LH secretion and LHRH self-priming.	Luteinizing Hormone	101-103	progesterone receptor	Rattus norvegicus	88-90
19654335-8	2009	In the effect of parabens on CaBP-9k expression through PR mediation, a significantly increased expression of uterine PR gene, a well-known ER-regulating gene, at both transcriptional and translational levels was indicated in the highest dose of isopropyl- and butylparaben.	Parabens	17-25	progesterone receptor	Rattus norvegicus	56-58
19654335-8	2009	In the effect of parabens on CaBP-9k expression through PR mediation, a significantly increased expression of uterine PR gene, a well-known ER-regulating gene, at both transcriptional and translational levels was indicated in the highest dose of isopropyl- and butylparaben.	Parabens	17-25	progesterone receptor	Rattus norvegicus	118-120
19654335-8	2009	In the effect of parabens on CaBP-9k expression through PR mediation, a significantly increased expression of uterine PR gene, a well-known ER-regulating gene, at both transcriptional and translational levels was indicated in the highest dose of isopropyl- and butylparaben.	isopropyl- and butylparaben	246-273	progesterone receptor	Rattus norvegicus	56-58
19654335-8	2009	In the effect of parabens on CaBP-9k expression through PR mediation, a significantly increased expression of uterine PR gene, a well-known ER-regulating gene, at both transcriptional and translational levels was indicated in the highest dose of isopropyl- and butylparaben.	isopropyl- and butylparaben	246-273	progesterone receptor	Rattus norvegicus	118-120
19654335-10	2009	This result indicates that CaBP-9k expression may involve with PR mediates in the estrogenic effect of paraben in immature rat uteri.	Parabens	103-110	progesterone receptor	Rattus norvegicus	63-65
19654335-11	2009	Taken together, parabens exhibited an estrogen-like property in vivo, which may be mediated by a PR and/or ER-alpha signaling pathway.	Parabens	16-24	progesterone receptor	Rattus norvegicus	97-99
19595590-0	2009	Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.	pyrrolidine	34-45	progesterone receptor	Rattus norvegicus	52-73
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	Amides	40-45	progesterone receptor	Rattus norvegicus	52-73
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	Amides	40-45	progesterone receptor	Rattus norvegicus	75-77
19595590-2	2009	Members of this class of N-alkylpyrrolidines demonstrate potent and highly selective partial agonism of the progesterone receptor, and one of these analogs was shown to be efficacious upon oral dosing in the OVX rat model of estrogen opposition.	n-alkylpyrrolidines	25-44	progesterone receptor	Rattus norvegicus	108-129
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	Amides	40-45	progesterone receptor	Rattus norvegicus	108-110
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	pyrrolidine	180-191	progesterone receptor	Rattus norvegicus	52-73
19595590-1	2009	Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed.	pyrrolidine	180-191	progesterone receptor	Rattus norvegicus	75-77
19217285-0	2009	Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.	pseudo-steroids	33-48	progesterone receptor	Rattus norvegicus	73-94
19389837-6	2009	To further explore Timp1 and Timp3 regulation, cells were cultured with the progesterone receptor antagonist RU486, which blocked the hCG induction of Timp3 expression, whereas the epidermal growth factor receptor tyrosine kinase inhibitor AG1478 blocked the hCG stimulation of both Timp1 and Timp3 expression.	Mifepristone	109-114	progesterone receptor	Rattus norvegicus	76-97
19450598-5	2009	Finally, we investigated the role of the high levels of progesterone typical of lactation in the suppression of estrogen-induced sexual behavior by transient blockade of the progesterone receptor using RU486.	Mifepristone	202-207	progesterone receptor	Rattus norvegicus	174-195
19460436-11	2009	Ormeloxifene also showed inhibitory effects on uterine ER-ERE binding and estrogen-induced expression of progesterone receptor.	ormeloxifene	0-12	progesterone receptor	Rattus norvegicus	105-126
19008332-0	2009	Bioconversion of norethisterone, a progesterone receptor agonist into estrogen receptor agonists in osteoblastic cells.	Norethindrone	17-31	progesterone receptor	Rattus norvegicus	35-56
19208546-1	2009	In this study, it was hypothesized that progesterone (P4) acts as a survival factor primarily by actions of the classic nuclear progesterone receptor (PGR) signaling pathway in rat periovulatory granulosa cells.	Progesterone	40-52	progesterone receptor	Rattus norvegicus	128-149
19208546-1	2009	In this study, it was hypothesized that progesterone (P4) acts as a survival factor primarily by actions of the classic nuclear progesterone receptor (PGR) signaling pathway in rat periovulatory granulosa cells.	Progesterone	40-52	progesterone receptor	Rattus norvegicus	151-154
19208546-9	2009	However, cotreatment with PGR antagonists protected cells from the additional effects of cyanoketone, indicating partial agonist effects of the antagonists and a dominating role for PGR in P4-mediated regulation of apoptosis.	Cyanoketone	89-100	progesterone receptor	Rattus norvegicus	26-29
19141682-7	2009	Administration of indomethacin to cyclic female rats disturbed ovulation and resulted in a dramatic drop in ovarian KiSS-1, but not GPR54, cyclooxygenase-2 (COX-2), or progesterone receptor, mRNA levels at the time of ovulation; an effect mimicked by the selective COX-2 inhibitor NS398 and rescued by coadministration of PGE(2).	Indomethacin	18-30	progesterone receptor	Rattus norvegicus	168-189
18539027-1	2008	Replacement of the 7-CH2 group of natural steroid with an oxygen atom led to identification of unnatural 7-oxa-steroids as potent and selective progesterone receptor antagonists.	7-oxa-steroids	105-119	progesterone receptor	Rattus norvegicus	144-165
18790044-6	2008	PR, ERalpha and C3 expression levels were modified in most of the endosulfan-treated groups, showing an identical pattern of expression to the NUE(2)-group.	Endosulfan	66-76	progesterone receptor	Rattus norvegicus	0-2
18553958-0	2008	A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.	7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno(3,4-f)quinoline	65-157	progesterone receptor	Rattus norvegicus	32-53
18539027-1	2008	Replacement of the 7-CH2 group of natural steroid with an oxygen atom led to identification of unnatural 7-oxa-steroids as potent and selective progesterone receptor antagonists.	Steroids	42-49	progesterone receptor	Rattus norvegicus	144-165
18539027-1	2008	Replacement of the 7-CH2 group of natural steroid with an oxygen atom led to identification of unnatural 7-oxa-steroids as potent and selective progesterone receptor antagonists.	Oxygen	58-64	progesterone receptor	Rattus norvegicus	144-165
18318463-0	2008	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).	pyrrole-oxindole	34-50	progesterone receptor	Rattus norvegicus	51-72
18403144-4	2008	Pretreated with three dosages of PGR water extract (0.75, 1.5 and 3g/kg, po) for 5 days, male Wistar rats (220-240 g) were intoxicated by phenylisothiocyanate (PITC, 100mg/kg, po) 24h before probes intravenous injection.	Water	37-42	progesterone receptor	Rattus norvegicus	33-36
18318463-0	2008	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).	5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile	95-187	progesterone receptor	Rattus norvegicus	51-72
18318463-0	2008	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).	5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile	189-199	progesterone receptor	Rattus norvegicus	51-72
18318463-1	2008	We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers.	3,3-dialkyl-5-aryloxindole	33-59	progesterone receptor	Rattus norvegicus	70-91
18318463-1	2008	We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers.	3,3-dialkyl-5-aryloxindole	33-59	progesterone receptor	Rattus norvegicus	93-95
18095567-10	2007	CONCLUSION: Lactational exposure to soy isoflavones could induce adverse effects on ovary development in neonate rats, which mechanisms may, at least, partically involved with modification of mRNA transcription for ER and PR.	Isoflavones	40-51	progesterone receptor	Rattus norvegicus	222-224
18274955-0	2008	Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin Delta 13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670.	alpha,beta-unsaturated ketone	150-179	progesterone receptor	Rattus norvegicus	91-94
18274955-0	2008	Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin Delta 13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670.	aryl propionic acid	186-205	progesterone receptor	Rattus norvegicus	91-94
18274955-0	2008	Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin Delta 13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670.	Cesium	244-246	progesterone receptor	Rattus norvegicus	91-94
18274955-8	2008	In addition to catalysing the biological reduction of eicosanoids, including prostaglandins, leukotrienes, and lipoxins, LTB(4) 12-HD/PGR was also determined to function as a xenobiotic-metabolizing enzyme.	Eicosanoids	54-65	progesterone receptor	Rattus norvegicus	134-137
18274955-8	2008	In addition to catalysing the biological reduction of eicosanoids, including prostaglandins, leukotrienes, and lipoxins, LTB(4) 12-HD/PGR was also determined to function as a xenobiotic-metabolizing enzyme.	Prostaglandins	77-91	progesterone receptor	Rattus norvegicus	134-137
18274955-8	2008	In addition to catalysing the biological reduction of eicosanoids, including prostaglandins, leukotrienes, and lipoxins, LTB(4) 12-HD/PGR was also determined to function as a xenobiotic-metabolizing enzyme.	Leukotrienes	93-105	progesterone receptor	Rattus norvegicus	134-137
17932647-6	2007	Further experiments dealt with the underlying mechanisms and revealed a rapid mode of action (50 mumol/l progesterone, reduction in insulin-stimulated glucose oxidation after 30 min: -29 +/- 7%, p < 0.01) not affected by blockers of gene expression or the nuclear progesterone receptor.	Progesterone	105-117	progesterone receptor	Rattus norvegicus	267-288
17640996-9	2007	In ovariectomized rats, low doses of TSC [10 or 20 mg/kg body weight (bw)] increased uterine wet weight (1.7- and 2.1-fold), and induced the expression of progesterone receptor and complement C3 in the uterus (2- and 26-fold) and mammary gland (4.4- and 15-fold).	tsc	37-40	progesterone receptor	Rattus norvegicus	155-176
18208546-0	2008	Endogenous oestradiol regulates progesterone receptor expression in the brain of female rat fetuses: what is the source of oestradiol?	Estradiol	11-21	progesterone receptor	Rattus norvegicus	32-53
18274955-0	2008	Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin Delta 13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670.	Leukotrienes	0-11	progesterone receptor	Rattus norvegicus	91-94
18001329-7	2007	In the progesterone-facilitation model, the LH response to GnRH injection was increased 2.5-3-fold (P < 0.05), an effect suppressed by the progesterone receptor antagonist, mifepristone.	Luteinizing Hormone	44-46	progesterone receptor	Rattus norvegicus	142-163
18001329-7	2007	In the progesterone-facilitation model, the LH response to GnRH injection was increased 2.5-3-fold (P < 0.05), an effect suppressed by the progesterone receptor antagonist, mifepristone.	Mifepristone	176-188	progesterone receptor	Rattus norvegicus	142-163
17681796-0	2007	5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist.	5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile	0-94	progesterone receptor	Rattus norvegicus	163-184
17681796-1	2007	We have recently discovered 5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (14) as a potent, selective, and orally active non-steroidal progesterone receptor (PR) agonist.	5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile	28-122	progesterone receptor	Rattus norvegicus	184-205
17681796-1	2007	We have recently discovered 5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (14) as a potent, selective, and orally active non-steroidal progesterone receptor (PR) agonist.	5-(3-cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile	28-122	progesterone receptor	Rattus norvegicus	207-209
17342739-2	2007	The mechanisms involved are unclear but progesterone receptor (PGR) antagonists have been shown to inhibit cholesterol synthesis and induce apoptosis.	Cholesterol	107-118	progesterone receptor	Rattus norvegicus	40-61
17342739-2	2007	The mechanisms involved are unclear but progesterone receptor (PGR) antagonists have been shown to inhibit cholesterol synthesis and induce apoptosis.	Cholesterol	107-118	progesterone receptor	Rattus norvegicus	63-66
17342739-5	2007	It has been suggested that PGR antagonists in a similar manner induce apoptosis by decreasing cholesterol synthesis and thereby protein isoprenylation.	Cholesterol	94-105	progesterone receptor	Rattus norvegicus	27-30
17342739-6	2007	In this study we hypothesized that the mechanism by which the nuclear PGR antagonist Org 31,710 induces apoptosis in rat periovulatory granulosa cells, is by decreasing cholesterol synthesis and thereby general cell protein isoprenylation.	Cholesterol	169-180	progesterone receptor	Rattus norvegicus	70-73
17342739-12	2007	In conclusion, we demonstrate that the PGR antagonist inhibits cholesterol synthesis in granulosa cells but reduced protein isoprenylation is not the mediating mechanism of increased apoptosis as previously hypothesized.	Cholesterol	63-74	progesterone receptor	Rattus norvegicus	39-42
17332059-1	2007	Progesterone (P), acting through progesterone receptor (PR) isoforms A and B, plays an important role in normal mammary gland development and is implicated in the etiology of breast cancer.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	33-54
17109827-2	2006	It has been postulated that cocaine"s modulation of serum progesterone levels may in turn alter progesterone receptor activity, thereby contributing to cocaine-induced alterations of neuronal functions and genomic regulations.	Cocaine	28-35	progesterone receptor	Rattus norvegicus	96-117
17400808-0	2007	The integrated action of oestrogen receptor isoforms and sites with progesterone receptor in the gonadotrope modulates LH secretion: evidence from tamoxifen-treated ovariectomized rats.	Luteinizing Hormone	119-121	progesterone receptor	Rattus norvegicus	68-89
17400808-0	2007	The integrated action of oestrogen receptor isoforms and sites with progesterone receptor in the gonadotrope modulates LH secretion: evidence from tamoxifen-treated ovariectomized rats.	Tamoxifen	147-156	progesterone receptor	Rattus norvegicus	68-89
17400808-6	2007	Results showed that i) EB and DPN potentiated the negative feedback of TX on basal LH release; ii) DPN reduced TX-induced PR expression; iii) EB and PPT blocked TX-elicited LHRH self-priming and iv) ZK299 reduced LHRH-stimulated LH secretion and blocked LHRH self-priming.	diarylpropionitrile	99-102	progesterone receptor	Rattus norvegicus	122-124
17400808-6	2007	Results showed that i) EB and DPN potentiated the negative feedback of TX on basal LH release; ii) DPN reduced TX-induced PR expression; iii) EB and PPT blocked TX-elicited LHRH self-priming and iv) ZK299 reduced LHRH-stimulated LH secretion and blocked LHRH self-priming.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	149-152	progesterone receptor	Rattus norvegicus	122-124
17356170-0	2007	A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.	asoprisnil	46-56	progesterone receptor	Rattus norvegicus	70-91
17356170-3	2007	We present the crystal structures of progesterone receptor (PR) ligand binding domain complexed with asoprisnil and the corepressors nuclear receptor corepressor (NCoR) and SMRT.	asoprisnil	101-111	progesterone receptor	Rattus norvegicus	37-58
17356170-5	2007	These structures show PR in a different conformation than PR complexed with progesterone (P4).	Progesterone	76-88	progesterone receptor	Rattus norvegicus	58-60
17356170-6	2007	We profiled asoprisnil in PR-dependent assays to understand further the PR-mediated mechanism of action.	asoprisnil	12-22	progesterone receptor	Rattus norvegicus	26-28
17356170-6	2007	We profiled asoprisnil in PR-dependent assays to understand further the PR-mediated mechanism of action.	asoprisnil	12-22	progesterone receptor	Rattus norvegicus	72-74
17356170-10	2007	Unlike RU486, NCoR binding to asoprisnil-bound PR could be displaced with equal affinity by NCoR or TIF2 peptides.	asoprisnil	30-40	progesterone receptor	Rattus norvegicus	47-49
17244199-2	2007	One physiological function of oestradiol is the induction of progesterone receptor (PR) expression in a variety of behaviourally relevant brain regions, including the ventromedial nucleus of the hypothalamus (VMN), the medial preoptic nucleus of the preoptic area (MPOA), the arcuate nucleus (ARC) and the medial central grey (MCG).	Estradiol	30-40	progesterone receptor	Rattus norvegicus	61-82
17244199-2	2007	One physiological function of oestradiol is the induction of progesterone receptor (PR) expression in a variety of behaviourally relevant brain regions, including the ventromedial nucleus of the hypothalamus (VMN), the medial preoptic nucleus of the preoptic area (MPOA), the arcuate nucleus (ARC) and the medial central grey (MCG).	Estradiol	30-40	progesterone receptor	Rattus norvegicus	84-86
17244199-4	2007	In previous studies, we have found that two of these nuclear receptor coactivators, steroid receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), are important in ER-mediated induction of PR in the VMN and in steroid-dependent behaviours.	Steroids	84-91	progesterone receptor	Rattus norvegicus	197-199
17244199-9	2007	These results, taken together with the findings that virtually all oestradiol-induced PR containing cells in the brain express ER, suggest that these neurones represent sites of functional interaction of nuclear receptor coactivators with ovarian steroid receptors in the brain.	Estradiol	67-77	progesterone receptor	Rattus norvegicus	86-88
17109827-2	2006	It has been postulated that cocaine"s modulation of serum progesterone levels may in turn alter progesterone receptor activity, thereby contributing to cocaine-induced alterations of neuronal functions and genomic regulations.	Progesterone	58-70	progesterone receptor	Rattus norvegicus	96-117
17109827-2	2006	It has been postulated that cocaine"s modulation of serum progesterone levels may in turn alter progesterone receptor activity, thereby contributing to cocaine-induced alterations of neuronal functions and genomic regulations.	Cocaine	152-159	progesterone receptor	Rattus norvegicus	96-117
17003284-6	2006	Exposure of E(2)-treated pituitary cells to 200 nM progesterone for 6 h decreased both PR-A and PR-B levels in rat cells, but had no effect on PR isoform expression in mouse cells even when exposure was extended to 12 h. The low level of PR expression found in LbetaT2 gonadotropes was unaffected by E(2), alone or with progesterone.	Progesterone	51-63	progesterone receptor	Rattus norvegicus	87-89
16934845-0	2006	Novel phosphorus-containing 17beta-side chain mifepristone analogues as progesterone receptor antagonists.	Phosphorus	6-16	progesterone receptor	Rattus norvegicus	72-93
16934845-0	2006	Novel phosphorus-containing 17beta-side chain mifepristone analogues as progesterone receptor antagonists.	Mifepristone	46-58	progesterone receptor	Rattus norvegicus	72-93
16934845-1	2006	A novel series of steroidal compounds were designed and synthesized with various phosphorus-containing groups on the 17beta-side chain as progesterone receptor antagonists.	Phosphorus	81-91	progesterone receptor	Rattus norvegicus	138-159
16934845-4	2006	Some of these compounds are more potent than mifepristone, with a better selectivity profile in differentiating progesterone receptor from glucocorticoid receptor.	Mifepristone	45-57	progesterone receptor	Rattus norvegicus	112-133
17003284-8	2006	Functionally, E(2)-stimulated changes in PR mRNA isoform ratios in rat, mouse or LbetaT2 cells correlated with the degree of progesterone augmentation of GnRH-stimulated LH secretion in these models.	Estradiol	14-18	progesterone receptor	Rattus norvegicus	41-43
17003284-8	2006	Functionally, E(2)-stimulated changes in PR mRNA isoform ratios in rat, mouse or LbetaT2 cells correlated with the degree of progesterone augmentation of GnRH-stimulated LH secretion in these models.	Luteinizing Hormone	170-172	progesterone receptor	Rattus norvegicus	41-43
16837612-1	2006	In the rat, administration of tamoxifen (TX) in the absence of oestrogen (E) induces LHRH self-priming, the progesterone receptor (PR)-dependent property of LHRH that increases gonadotrope responsiveness to itself.	Tamoxifen	30-39	progesterone receptor	Rattus norvegicus	108-129
16825604-9	2006	Treatment with RU486, a progesterone receptor (PR) antagonist, completely blocked P4-induced CaT1 mRNA, indicating that P4 regulates CaT1 mRNA expression via a PR-mediated pathway.	Mifepristone	15-20	progesterone receptor	Rattus norvegicus	24-45
16825604-9	2006	Treatment with RU486, a progesterone receptor (PR) antagonist, completely blocked P4-induced CaT1 mRNA, indicating that P4 regulates CaT1 mRNA expression via a PR-mediated pathway.	Mifepristone	15-20	progesterone receptor	Rattus norvegicus	47-49
16825604-9	2006	Treatment with RU486, a progesterone receptor (PR) antagonist, completely blocked P4-induced CaT1 mRNA, indicating that P4 regulates CaT1 mRNA expression via a PR-mediated pathway.	Mifepristone	15-20	progesterone receptor	Rattus norvegicus	160-162
16818706-8	2006	RU-486 delayed the latency period and decreased tumor incidence in animals exposed to MPA at 4 weeks after DMBA treatment, indicating that the progesterone receptor may be partially responsible for transmission of proliferative signals.	Mifepristone	0-6	progesterone receptor	Rattus norvegicus	143-164
16837612-0	2006	Oestradiol-17beta inhibits tamoxifen-induced LHRH self-priming blocking hormone-dependent and ligand-independent activation of the gonadotrope progesterone receptor in the rat.	Estradiol	0-17	progesterone receptor	Rattus norvegicus	143-164
16837612-0	2006	Oestradiol-17beta inhibits tamoxifen-induced LHRH self-priming blocking hormone-dependent and ligand-independent activation of the gonadotrope progesterone receptor in the rat.	Tamoxifen	27-36	progesterone receptor	Rattus norvegicus	143-164
16942525-12	2006	CONCLUSION: Estradiol down-regulated ERalpha and up-regulated PR expression in the vagina, suggesting this may be a mechanism to prevent continued proliferation of the epithelium by surges of estradiol during the estrous cycle.	Estradiol	192-201	progesterone receptor	Rattus norvegicus	62-64
16837612-1	2006	In the rat, administration of tamoxifen (TX) in the absence of oestrogen (E) induces LHRH self-priming, the progesterone receptor (PR)-dependent property of LHRH that increases gonadotrope responsiveness to itself.	Tamoxifen	30-39	progesterone receptor	Rattus norvegicus	131-133
16837612-2	2006	The oestrogen-dependent PR can be phosphorylated/activated by progesterone (P4) and, in the absence of the cognate ligand, by intracellular LHRH signals, particularly cAMP/protein kinase A.	Progesterone	62-74	progesterone receptor	Rattus norvegicus	24-26
16837612-2	2006	The oestrogen-dependent PR can be phosphorylated/activated by progesterone (P4) and, in the absence of the cognate ligand, by intracellular LHRH signals, particularly cAMP/protein kinase A.	Cyclic AMP	167-171	progesterone receptor	Rattus norvegicus	24-26
16837883-8	2006	Vaginal progesterone receptor protein was increased fivefold by estradiol and all three SERMs tested.	Estradiol	64-73	progesterone receptor	Rattus norvegicus	8-29
16233985-3	2006	The stimulatory action of progesterone on nitric oxide synthase (NOS) activity was maintained even in the presence of an antagonist of progesterone receptor, compound RU486.	Mifepristone	167-172	progesterone receptor	Rattus norvegicus	135-156
16837889-11	2006	The high doses of E(2) and 8-PN caused secretion in the mammary gland, whereas proliferation and progesterone receptor expression were stimulated by both E(2) doses and the high 8-PN dose.	8-prenylnaringenin	178-182	progesterone receptor	Rattus norvegicus	97-118
16595727-1	2006	In the absence of estrogen (E), the selective E receptor modulator tamoxifen (TX) has two agonist effects in the rat pituitary: induction of progesterone receptor (PR)-dependent GnRH self-priming in the gonadotrope, and stimulation of prolactin (PRL) secretion in the lactotrope.	Tamoxifen	67-76	progesterone receptor	Rattus norvegicus	141-162
16595727-1	2006	In the absence of estrogen (E), the selective E receptor modulator tamoxifen (TX) has two agonist effects in the rat pituitary: induction of progesterone receptor (PR)-dependent GnRH self-priming in the gonadotrope, and stimulation of prolactin (PRL) secretion in the lactotrope.	Tamoxifen	67-76	progesterone receptor	Rattus norvegicus	164-166
16414171-11	2006	PBDE 99 also influenced baseline levels of PR, IGF-I and ER beta mRNAs in ovariectomized, vehicle-injected controls.	2,2',4,4',5-brominated diphenyl ether	0-7	progesterone receptor	Rattus norvegicus	43-45
16284289-6	2005	Progesterone exerted a stimulatory effect through the progesterone receptor on the induction of ROS generation processes and intracellular pathways, resulting in TGF-beta1 expression and HSC activation, and fibrogenic effects were inhibited by oestradiol.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	54-75
16461543-2	2006	Since LC neurons are responsive to estradiol, which induces progesterone receptor (PR) expression, this study aimed to investigate whether LC neurons express the alpha-estradiol receptor (alphaER) and PR as well as comparing such responses to that observed in the preoptic area (POA).	Estradiol	35-44	progesterone receptor	Rattus norvegicus	60-81
16461543-2	2006	Since LC neurons are responsive to estradiol, which induces progesterone receptor (PR) expression, this study aimed to investigate whether LC neurons express the alpha-estradiol receptor (alphaER) and PR as well as comparing such responses to that observed in the preoptic area (POA).	Estradiol	35-44	progesterone receptor	Rattus norvegicus	83-85
16461543-12	2006	This profile of alphaER and PR expression might be related to the ability of estradiol and progesterone in regulating the activity of LC neurons, which could be associated to the control mechanisms of LH and prolactin release.	Progesterone	91-103	progesterone receptor	Rattus norvegicus	28-30
17033158-6	2006	The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective.	4-nonylphenol	109-111	progesterone receptor	Rattus norvegicus	18-39
17033158-6	2006	The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective.	bisphenol A	117-128	progesterone receptor	Rattus norvegicus	18-39
17033158-6	2006	The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective.	Estradiol	133-142	progesterone receptor	Rattus norvegicus	18-39
17033158-6	2006	The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective.	bisphenol A	148-159	progesterone receptor	Rattus norvegicus	18-39
16284289-6	2005	Progesterone exerted a stimulatory effect through the progesterone receptor on the induction of ROS generation processes and intracellular pathways, resulting in TGF-beta1 expression and HSC activation, and fibrogenic effects were inhibited by oestradiol.	Reactive Oxygen Species	96-99	progesterone receptor	Rattus norvegicus	54-75
16284289-6	2005	Progesterone exerted a stimulatory effect through the progesterone receptor on the induction of ROS generation processes and intracellular pathways, resulting in TGF-beta1 expression and HSC activation, and fibrogenic effects were inhibited by oestradiol.	Estradiol	244-254	progesterone receptor	Rattus norvegicus	54-75
15456929-3	2004	142, 203-214, have reported that administration of 5-150 mg/kg/day BPA to immature rats leads to increases in uterine peroxidase activity and progesterone receptor (PR) protein levels in the absence of a uterotrophic response.	bisphenol A	67-70	progesterone receptor	Rattus norvegicus	142-163
16145313-9	2005	17beta-estradiol, but not the SSE, down-regulated uterine epithelial progesterone receptor (PR), compared with ovariectomized rats.	Estradiol	0-16	progesterone receptor	Rattus norvegicus	69-90
16145313-9	2005	17beta-estradiol, but not the SSE, down-regulated uterine epithelial progesterone receptor (PR), compared with ovariectomized rats.	Estradiol	0-16	progesterone receptor	Rattus norvegicus	92-94
16145313-10	2005	In the stromal compartment, progesterone receptor expression was fully up-regulated by 17beta-estradiol treatment and, to a lesser extent, by SSE treatment.	Estradiol	87-103	progesterone receptor	Rattus norvegicus	28-49
15914137-8	2005	In immature rats, ormeloxifene caused a dose-dependent increase in cytosolic PR levels; ormeloxifene given along with E(2) (0.1 mug) for 3 days caused a significant reduction in concentration of PRs at 10 mug and higher doses.	ormeloxifene	18-30	progesterone receptor	Rattus norvegicus	77-79
21783553-0	2005	Sex- and region-specific alterations of progesterone receptor mRNA levels and estrogen sensitivity in rat brain following developmental exposure to the estrogenic UV filter 4-methylbenzylidene camphor.	4-methylbenzylidene	173-192	progesterone receptor	Rattus norvegicus	40-61
21783553-0	2005	Sex- and region-specific alterations of progesterone receptor mRNA levels and estrogen sensitivity in rat brain following developmental exposure to the estrogenic UV filter 4-methylbenzylidene camphor.	Camphor	193-200	progesterone receptor	Rattus norvegicus	40-61
15743919-0	2005	Endocrinological properties of two novel nonsteroidal progesterone receptor modulators, CP8816 and CP8863.	CP8816	88-94	progesterone receptor	Rattus norvegicus	54-75
15743919-0	2005	Endocrinological properties of two novel nonsteroidal progesterone receptor modulators, CP8816 and CP8863.	CP8863	99-105	progesterone receptor	Rattus norvegicus	54-75
15743919-3	2005	Both CP8816 and CP8863 demonstrated selective binding to progesterone receptor and partial agonistic activity in a progesterone-dependent endogenous alkaline phosphatase expression assay.	CP8816	5-11	progesterone receptor	Rattus norvegicus	57-78
15743919-3	2005	Both CP8816 and CP8863 demonstrated selective binding to progesterone receptor and partial agonistic activity in a progesterone-dependent endogenous alkaline phosphatase expression assay.	CP8863	16-22	progesterone receptor	Rattus norvegicus	57-78
15743919-9	2005	Thus, these progesterone receptor modulator profiles suggest that CP8863 and CP8816 are good candidate compounds for treatment of hormone-dependent gynecological disorders.	CP8863	66-72	progesterone receptor	Rattus norvegicus	12-33
15743919-9	2005	Thus, these progesterone receptor modulator profiles suggest that CP8863 and CP8816 are good candidate compounds for treatment of hormone-dependent gynecological disorders.	CP8816	77-83	progesterone receptor	Rattus norvegicus	12-33
15385411-0	2005	Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro.	Cholesterol	63-74	progesterone receptor	Rattus norvegicus	0-21
15385411-8	2005	These results show that PR antagonists reduce cholesterol synthesis in periovulatory granulosa cells and that cholesterol synthesis is important for granulosa cell survival.	Cholesterol	46-57	progesterone receptor	Rattus norvegicus	24-26
15976009-10	2005	Collectively, these findings provide evidence that progesterone receptor-dependent receptivity is, in part, dependent on PAC1 receptors for intracellular VMN signaling and delineate a novel, steroid-dependent mechanism for a feed-forward reinforcement of steroid receptor-dependent reproductive receptivity.	Steroids	191-198	progesterone receptor	Rattus norvegicus	51-72
15642783-0	2005	Gonadotrope oestrogen receptor-alpha and -beta and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion.	estradiol 3-benzoate	124-143	progesterone receptor	Rattus norvegicus	51-72
15642783-0	2005	Gonadotrope oestrogen receptor-alpha and -beta and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion.	Tamoxifen	145-154	progesterone receptor	Rattus norvegicus	51-72
15642783-0	2005	Gonadotrope oestrogen receptor-alpha and -beta and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion.	Raloxifene Hydrochloride	158-168	progesterone receptor	Rattus norvegicus	51-72
15642783-0	2005	Gonadotrope oestrogen receptor-alpha and -beta and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion.	Luteinizing Hormone	198-200	progesterone receptor	Rattus norvegicus	51-72
15642783-6	2005	As in pro-oestrus, pituitaries from OVX rats treated with EB exhibited GnRH-stimulated LH secretion, immunohistochemical PR expression and GnRH self-priming.	ethylbenzene	58-60	progesterone receptor	Rattus norvegicus	121-123
15456929-3	2004	142, 203-214, have reported that administration of 5-150 mg/kg/day BPA to immature rats leads to increases in uterine peroxidase activity and progesterone receptor (PR) protein levels in the absence of a uterotrophic response.	bisphenol A	67-70	progesterone receptor	Rattus norvegicus	165-167
14645109-8	2004	Treatment of pregnant rats with the progesterone receptor antagonist RU486 on Day 19 induced preterm labor on Day 20 and a premature increase in mRNA levels of collagen IV, fibronectin, and laminin.	Mifepristone	69-74	progesterone receptor	Rattus norvegicus	36-57
15344660-1	2004	Competition of a number of progesterone 16alpha,17alpha-cycloalkane derivatives with 3H-labeled ligands for the binding sites of the rat uterine progesterone receptor, uterine pentaranophilin, and blood serum pentaranophilin was studied.	progesterone 16alpha	27-47	progesterone receptor	Rattus norvegicus	145-166
15344660-1	2004	Competition of a number of progesterone 16alpha,17alpha-cycloalkane derivatives with 3H-labeled ligands for the binding sites of the rat uterine progesterone receptor, uterine pentaranophilin, and blood serum pentaranophilin was studied.	17alpha-cycloalkane	48-67	progesterone receptor	Rattus norvegicus	145-166
15344660-1	2004	Competition of a number of progesterone 16alpha,17alpha-cycloalkane derivatives with 3H-labeled ligands for the binding sites of the rat uterine progesterone receptor, uterine pentaranophilin, and blood serum pentaranophilin was studied.	Tritium	85-87	progesterone receptor	Rattus norvegicus	145-166
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	4-7	progesterone receptor	Rattus norvegicus	41-43
14763995-0	2004	p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats.	4-nonylphenol	0-13	progesterone receptor	Rattus norvegicus	77-98
14763995-0	2004	p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats.	4-tert-octylphenol	15-33	progesterone receptor	Rattus norvegicus	77-98
14763995-0	2004	p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized rats.	bisphenol A	38-49	progesterone receptor	Rattus norvegicus	77-98
14763995-5	2004	In a second experiment to study the time-course of the effects of BPA on PR mRNA, the ovariectomized rats were given a subcutaneous injection of 10 mg of BPA and killed 0, 6, 12 and 24 h after injection.	bisphenol A	66-69	progesterone receptor	Rattus norvegicus	73-75
14763995-8	2004	In the temporal cortex, BPA significantly decreased PR mRNA, but NP and OP produced no significant changes.	bisphenol A	24-27	progesterone receptor	Rattus norvegicus	52-54
14763995-9	2004	The second experiment revealed that, in the frontal cortex, BPA induced a significant increase in PR mRNA expression at 6 h after injection, which lasted until 24 h after injection.	bisphenol A	60-63	progesterone receptor	Rattus norvegicus	98-100
14763995-10	2004	In the temporal cortex, PR mRNA expression was significantly decreased 6 h after injection of BPA and was still significantly low 24 h after injection.	bisphenol A	94-97	progesterone receptor	Rattus norvegicus	24-26
14709783-6	2004	In pregnant dams treated with genistein (GEN; 15 mg/kg body weight) by gavage, from Gestational Day 14 through weaning, PR expression in the uterine glandular epithelium from 2-month-old GEN-treated females (postexposure) was also significantly increased.	Genistein	30-39	progesterone receptor	Rattus norvegicus	120-122
14709783-7	2004	Diethylstilbesterol (DES) also stimulated uterine PR expression only in the glandular but not luminal epithelial cells.	Diethylstilbestrol	0-19	progesterone receptor	Rattus norvegicus	50-52
14709783-7	2004	Diethylstilbesterol (DES) also stimulated uterine PR expression only in the glandular but not luminal epithelial cells.	Diethylstilbestrol	21-24	progesterone receptor	Rattus norvegicus	50-52
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	4-7	progesterone receptor	Rattus norvegicus	112-114
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	12-15	progesterone receptor	Rattus norvegicus	41-43
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	12-15	progesterone receptor	Rattus norvegicus	112-114
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	diarylpropionitrile	16-19	progesterone receptor	Rattus norvegicus	41-43
15205556-8	2004	EB, PPT and PPT+DPN treatments increased PR mRNA and the number and intensity of nuclei immunoreactive (IR) for PR in gonadotropes, and reduced the number of gonadectomy cells.	diarylpropionitrile	16-19	progesterone receptor	Rattus norvegicus	112-114
15205556-10	2004	DPN alone had only a significant E-like effect on gonadectomy cells and IR-PR, but not on GnRH self-priming.	diarylpropionitrile	0-3	progesterone receptor	Rattus norvegicus	75-77
14967892-8	2003	In rats on P18, 17beta-estradiol injection did not change PR mRNA levels after sham-operation but induced an increase in PR mRNA levels of rats ovariectomized 6 h before the treatment.	Estradiol	16-32	progesterone receptor	Rattus norvegicus	121-123
14672731-2	2003	In the present study, its affinity to the progesterone receptor (PgR), the androgen receptor (AR) and the estrogen receptor (ER) was re-evaluated and compared to those obtained for progesterone (P) and several progestins.	Progesterone	42-54	progesterone receptor	Rattus norvegicus	65-68
12929590-7	2003	However, estrogen receptor alpha (ER alpha)- and progesterone receptor (PgR)-positive cells, p63-positive cells and proliferating cell nuclear antigen (PCNA)-labeling index were lower in genistein-exposed TEBs.	Genistein	187-196	progesterone receptor	Rattus norvegicus	49-70
14667974-5	2003	In additional experiments, utilizing agonists and antagonists of PR and GABAA receptor, we have observed that progesterone and its derivatives control Po gene expression via the PR, while tetrahydroprogesterone modulates the expression of PMP22 through the GABAA receptor.	Progesterone	110-122	progesterone receptor	Rattus norvegicus	65-67
14667974-5	2003	In additional experiments, utilizing agonists and antagonists of PR and GABAA receptor, we have observed that progesterone and its derivatives control Po gene expression via the PR, while tetrahydroprogesterone modulates the expression of PMP22 through the GABAA receptor.	Progesterone	110-122	progesterone receptor	Rattus norvegicus	178-180
12969244-0	2003	Changes in progesterone receptor isoforms content in the rat brain during the oestrous cycle and after oestradiol and progesterone treatments.	Estradiol	103-113	progesterone receptor	Rattus norvegicus	11-32
12969244-1	2003	We studied the effects of oestradiol and progesterone on progesterone receptor (PR) isoform content in the brain of ovariectomized rats and in intact rats during the oestrous cycle by Western blot analysis.	Progesterone	41-53	progesterone receptor	Rattus norvegicus	57-78
12969244-2	2003	In the hypothalamus and the preoptic area of ovariectomized rats, PR-A and PR-B content was increased by oestradiol, whereas progesterone significantly diminished the content of both PR isoforms after 3 h of treatment in the hypothalamus, but not in the preoptic area.	Estradiol	105-115	progesterone receptor	Rattus norvegicus	66-68
12969244-7	2003	These results indicate that the expression of PR isoforms is differentially regulated by sex steroid hormones in a regionally specific manner.	Steroids	93-109	progesterone receptor	Rattus norvegicus	46-48
12918018-2	2003	The objective of the present study was to determine PR protein and gene expression pattern in preoptic-anterior hypothalamic area (POA-AHA) and hypothalamus (HYP), after estradiol or testosterone treatment during the postnatal critical period of sexual differentiation of the rat brain (defeminized animals).	Testosterone	183-195	progesterone receptor	Rattus norvegicus	52-54
12918018-7	2003	We observed that PR mRNA expression was increased in POA-AHA and HYP of the animals treated with estradiol or testosterone 3 hours after treatments, compared with the vehicle-treated control group.	Estradiol	97-106	progesterone receptor	Rattus norvegicus	17-19
12918018-7	2003	We observed that PR mRNA expression was increased in POA-AHA and HYP of the animals treated with estradiol or testosterone 3 hours after treatments, compared with the vehicle-treated control group.	Testosterone	110-122	progesterone receptor	Rattus norvegicus	17-19
12918018-8	2003	We also found a significant increase in PR mRNA and protein expression in POA-AHA and HYP on the day of VO in both estradiol and testosterone defeminized rats.	Estradiol	115-124	progesterone receptor	Rattus norvegicus	40-42
12918018-10	2003	The overall results suggest that estradiol and testosterone treatment during the postnatal critical period of sexual differentiation of the brain modifies the regulation of the PR mRNA and protein expression during early onset of maturity.	Testosterone	47-59	progesterone receptor	Rattus norvegicus	177-179
12929590-7	2003	However, estrogen receptor alpha (ER alpha)- and progesterone receptor (PgR)-positive cells, p63-positive cells and proliferating cell nuclear antigen (PCNA)-labeling index were lower in genistein-exposed TEBs.	Genistein	187-196	progesterone receptor	Rattus norvegicus	72-75
12929590-10	2003	The present findings suggest that administration of genistein in the perinatal period has protective effects against MNU-induced mammary carcinoma in Sprague-Dawley rats, via reduction of levels of ER alpha- and/or PgR-positive cells (presumed progenitor cells of mammary carcinomas), p63-positive mammary progenitor/stem cells (involved in cell renewal) and PCNA-positive cells (necessary for cell proliferation).	Genistein	52-61	progesterone receptor	Rattus norvegicus	215-218
12657271-0	2003	Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.	6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones	6-49	progesterone receptor	Rattus norvegicus	103-124
12798354-0	2003	Regulation of progesterone receptor isoforms expression by sex steroids in the rat lung.	Steroids	63-71	progesterone receptor	Rattus norvegicus	14-35
12798354-1	2003	In this work, we determined the expression pattern and the hormonal regulation of progesterone receptor (PR) isoforms in the rat lung of ovariectomized female rats after estradiol (E2) and progesterone (P4) treatments.	Estradiol	170-179	progesterone receptor	Rattus norvegicus	82-103
12798354-1	2003	In this work, we determined the expression pattern and the hormonal regulation of progesterone receptor (PR) isoforms in the rat lung of ovariectomized female rats after estradiol (E2) and progesterone (P4) treatments.	Estradiol	170-179	progesterone receptor	Rattus norvegicus	105-107
12798354-1	2003	In this work, we determined the expression pattern and the hormonal regulation of progesterone receptor (PR) isoforms in the rat lung of ovariectomized female rats after estradiol (E2) and progesterone (P4) treatments.	Progesterone	82-94	progesterone receptor	Rattus norvegicus	105-107
12419537-3	2002	We hypothesize that the PE state may develop due to a diminished level of estrogen-induced progesterone receptor (PR) expression in the hypothalamus that prevents progesterone from stimulating LH regulating circuits.	Progesterone	91-103	progesterone receptor	Rattus norvegicus	114-116
12535155-0	2003	Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats.	bisphenol A	0-11	progesterone receptor	Rattus norvegicus	22-43
12535155-1	2003	Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats.	bisphenol A	27-38	progesterone receptor	Rattus norvegicus	80-101
12535155-1	2003	Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats.	bisphenol A	27-38	progesterone receptor	Rattus norvegicus	103-105
12535155-1	2003	Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats.	bisphenol A	40-43	progesterone receptor	Rattus norvegicus	80-101
12535155-1	2003	Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats.	bisphenol A	40-43	progesterone receptor	Rattus norvegicus	103-105
12535155-2	2003	In the present study, we examined whether BPA also induced expression of PR proteins in both the POA and the ventromedial hypothalamic nucleus (VMH), and whether those proteins were involved in the induction of sexual behaviour.	bisphenol A	42-45	progesterone receptor	Rattus norvegicus	73-75
12535155-8	2003	Furthermore, BPA induced a dose-dependent increase in the number of PR immunoreactive cells in both the POA and the VMH, demonstrating that the number of PR cells was significantly increased by as little as 100 microg of BPA.	bisphenol A	13-16	progesterone receptor	Rattus norvegicus	68-70
12535155-8	2003	Furthermore, BPA induced a dose-dependent increase in the number of PR immunoreactive cells in both the POA and the VMH, demonstrating that the number of PR cells was significantly increased by as little as 100 microg of BPA.	bisphenol A	13-16	progesterone receptor	Rattus norvegicus	154-156
12535155-8	2003	Furthermore, BPA induced a dose-dependent increase in the number of PR immunoreactive cells in both the POA and the VMH, demonstrating that the number of PR cells was significantly increased by as little as 100 microg of BPA.	bisphenol A	221-224	progesterone receptor	Rattus norvegicus	68-70
12535155-8	2003	Furthermore, BPA induced a dose-dependent increase in the number of PR immunoreactive cells in both the POA and the VMH, demonstrating that the number of PR cells was significantly increased by as little as 100 microg of BPA.	bisphenol A	221-224	progesterone receptor	Rattus norvegicus	154-156
12535155-10	2003	The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus.	bisphenol A	32-35	progesterone receptor	Rattus norvegicus	133-135
12475720-2	2003	The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 10 times weaker in binding and half as potent in transactivation of PR; 3alpha- and 3beta-hydroxytibolone did not bind or activate PR.	tibolone	94-102	progesterone receptor	Rattus norvegicus	66-87
12475720-2	2003	The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 10 times weaker in binding and half as potent in transactivation of PR; 3alpha- and 3beta-hydroxytibolone did not bind or activate PR.	tibolone	94-102	progesterone receptor	Rattus norvegicus	175-177
12475720-2	2003	The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 10 times weaker in binding and half as potent in transactivation of PR; 3alpha- and 3beta-hydroxytibolone did not bind or activate PR.	tibolone	94-102	progesterone receptor	Rattus norvegicus	175-177
12388156-9	2002	Tamoxifen delayed parturition and inhibited the increase in PR-total without affecting PR-B mRNA.	Tamoxifen	0-9	progesterone receptor	Rattus norvegicus	60-62
12388156-10	2002	RU-486 caused early parturition associated with increased PR-total mRNA, with no change in PR-B.	Mifepristone	0-6	progesterone receptor	Rattus norvegicus	58-60
12419537-3	2002	We hypothesize that the PE state may develop due to a diminished level of estrogen-induced progesterone receptor (PR) expression in the hypothalamus that prevents progesterone from stimulating LH regulating circuits.	Luteinizing Hormone	193-195	progesterone receptor	Rattus norvegicus	91-112
12419537-3	2002	We hypothesize that the PE state may develop due to a diminished level of estrogen-induced progesterone receptor (PR) expression in the hypothalamus that prevents progesterone from stimulating LH regulating circuits.	Luteinizing Hormone	193-195	progesterone receptor	Rattus norvegicus	114-116
12385821-7	2002	In addition, E(2)-stimulated transactivation of an estrogen-response-element reporter gene as well as E(2)-induced upregulation of the PR were also inhibited by PR ligands.	Estradiol	13-17	progesterone receptor	Rattus norvegicus	135-137
12457037-4	2002	Estradiol-induced PR expression in the preoptic area and the hippocampus, whereas progesterone did not modify the effect of estradiol.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	18-20
12457039-2	2002	Since GAD(67) is the major synthetic enzyme for the inhibitory transmitter, gamma-aminobutyric acid, the finding raised the possibility that the endogenous activation of the progesterone receptor may act to restrain GAD(67) expression during the natural preovulatory gonadotropin surge during proestrus in the rat, thereby allowing GnRH secretion and the resultant LH surge.	gamma-Aminobutyric Acid	76-99	progesterone receptor	Rattus norvegicus	174-195
12457039-3	2002	To test this hypothesis, the progesterone receptor antagonist, RU486, was administered to regularly cycling proestrous rats and the effect on GAD(67) and GAD(65) mRNA levels in the preoptic area (POA) and medial basal hypothalamus (MBH) was examined.	Mifepristone	63-68	progesterone receptor	Rattus norvegicus	29-50
12385821-7	2002	In addition, E(2)-stimulated transactivation of an estrogen-response-element reporter gene as well as E(2)-induced upregulation of the PR were also inhibited by PR ligands.	Estradiol	13-17	progesterone receptor	Rattus norvegicus	161-163
12385821-7	2002	In addition, E(2)-stimulated transactivation of an estrogen-response-element reporter gene as well as E(2)-induced upregulation of the PR were also inhibited by PR ligands.	Estradiol	102-106	progesterone receptor	Rattus norvegicus	135-137
12385821-7	2002	In addition, E(2)-stimulated transactivation of an estrogen-response-element reporter gene as well as E(2)-induced upregulation of the PR were also inhibited by PR ligands.	Estradiol	102-106	progesterone receptor	Rattus norvegicus	161-163
12215663-9	2002	CPA caused effects consistent with its mixed AR antagonist/progesterone receptor agonist activity: it decreased ASG weights, caused hormonal alterations (increased T and E2; decreased FSH), and caused spermatid retention.	Cyproterone Acetate	0-3	progesterone receptor	Rattus norvegicus	59-80
12372000-11	2002	These findings suggest that differences in steroid secretion by the neonatal male and female gonads are responsible for producing sex differences in the level of PR expression in the postnatal MPN.	Steroids	43-50	progesterone receptor	Rattus norvegicus	162-164
12238914-0	2002	6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.	6-aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones	0-46	progesterone receptor	Rattus norvegicus	115-136
12238914-1	2002	Novel 6-aryl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones were synthesized and tested as progesterone receptor (PR) antagonists.	6-aryl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones	6-51	progesterone receptor	Rattus norvegicus	83-104
12238914-1	2002	Novel 6-aryl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones were synthesized and tested as progesterone receptor (PR) antagonists.	6-aryl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones	6-51	progesterone receptor	Rattus norvegicus	106-108
12238914-2	2002	These compounds were potent and showed good selectivity for PR over other steroid receptors such as the glucocorticoid and androgen receptors (e.g., greater than 80-fold selectivity at PR for 4h).	4h	192-194	progesterone receptor	Rattus norvegicus	60-62
12238914-2	2002	These compounds were potent and showed good selectivity for PR over other steroid receptors such as the glucocorticoid and androgen receptors (e.g., greater than 80-fold selectivity at PR for 4h).	4h	192-194	progesterone receptor	Rattus norvegicus	185-187
12189189-8	2002	Immunoblotting analyis of mammary gland extracts demonstrated increased epidermal growth factor receptor (EGFR) and progesterone receptor (PR) expression following treatment with EB or genistein.	estradiol 3-benzoate	179-181	progesterone receptor	Rattus norvegicus	116-137
12189189-8	2002	Immunoblotting analyis of mammary gland extracts demonstrated increased epidermal growth factor receptor (EGFR) and progesterone receptor (PR) expression following treatment with EB or genistein.	estradiol 3-benzoate	179-181	progesterone receptor	Rattus norvegicus	139-141
12189189-8	2002	Immunoblotting analyis of mammary gland extracts demonstrated increased epidermal growth factor receptor (EGFR) and progesterone receptor (PR) expression following treatment with EB or genistein.	Genistein	185-194	progesterone receptor	Rattus norvegicus	116-137
12189189-8	2002	Immunoblotting analyis of mammary gland extracts demonstrated increased epidermal growth factor receptor (EGFR) and progesterone receptor (PR) expression following treatment with EB or genistein.	Genistein	185-194	progesterone receptor	Rattus norvegicus	139-141
12379440-1	2002	We studied the effects of estradiol (E2) and progesterone (P) on progesterone receptor (PR) isoforms gene expression in the brain of ovariectomised female and gonadectomised male rats by RT-PCR analysis.	Progesterone	45-57	progesterone receptor	Rattus norvegicus	65-86
12379440-1	2002	We studied the effects of estradiol (E2) and progesterone (P) on progesterone receptor (PR) isoforms gene expression in the brain of ovariectomised female and gonadectomised male rats by RT-PCR analysis.	Progesterone	45-57	progesterone receptor	Rattus norvegicus	88-90
12379440-7	2002	These results demonstrate a clear sexual dimorphism in the regulation of PR isoforms expression by sex steroid hormones in the rat brain, suggesting that this sex difference contributes to the sexually dimorphic effects of P in the rat brain.	Steroids	103-110	progesterone receptor	Rattus norvegicus	73-75
12065892-6	2002	Estradiol-induced increases in the number of progesterone receptor-immunoreactive cells in the hypothalamic ventromedial nucleus and the medial preoptic area were not inhibited by this dose of ICI but were inhibited by 500 microg/day tamoxifen, an antiestrogen that can cross the blood-brain barrier.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	45-66
12080023-7	2002	In contrast, administration of the progesterone receptor antagonist RU486 (10 mg/kg s.c.) on Day 19 induced preterm labor and a premature increase in mRNA levels of c-fos, fra-1, fra-2, and junB.	Mifepristone	68-73	progesterone receptor	Rattus norvegicus	35-56
12106699-8	2002	In contrast, tamoxifen exhibits antagonist properties with respect to estrogen-induction of progesterone receptor mRNA in the medial preoptic nucleus.	Tamoxifen	13-22	progesterone receptor	Rattus norvegicus	92-113
12065892-6	2002	Estradiol-induced increases in the number of progesterone receptor-immunoreactive cells in the hypothalamic ventromedial nucleus and the medial preoptic area were not inhibited by this dose of ICI but were inhibited by 500 microg/day tamoxifen, an antiestrogen that can cross the blood-brain barrier.	Tamoxifen	234-243	progesterone receptor	Rattus norvegicus	45-66
11804181-0	2001	Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea.	vorozole	34-42	progesterone receptor	Rattus norvegicus	59-80
11958787-0	2002	Pregna-D"-pentarane structure influences progesterone receptor affinity for DNA.	d"-pentarane	7-19	progesterone receptor	Rattus norvegicus	41-62
11958787-1	2002	Electrophoretic mobility shift assay was used to determine whether pregna-D"-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containing oligonucleotide duplexes and to measure the affinity of this interaction.	d"-pentaranes	74-87	progesterone receptor	Rattus norvegicus	94-115
11958787-1	2002	Electrophoretic mobility shift assay was used to determine whether pregna-D"-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containing oligonucleotide duplexes and to measure the affinity of this interaction.	d"-pentaranes	74-87	progesterone receptor	Rattus norvegicus	117-119
11958787-1	2002	Electrophoretic mobility shift assay was used to determine whether pregna-D"-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containing oligonucleotide duplexes and to measure the affinity of this interaction.	Oligonucleotides	196-211	progesterone receptor	Rattus norvegicus	94-115
11958787-1	2002	Electrophoretic mobility shift assay was used to determine whether pregna-D"-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containing oligonucleotide duplexes and to measure the affinity of this interaction.	Oligonucleotides	196-211	progesterone receptor	Rattus norvegicus	117-119
11958787-2	2002	The formation of DNA-protein complexes in low salt medium was progesterone-related ligand-, temperature-, and PR-dependent, and specific for HRE.	low salt	42-50	progesterone receptor	Rattus norvegicus	110-112
11958787-3	2002	The highest affinity of PR to DNA (equilibrium K(a) = 0.420 +/- 0.185 nM(-1)) was found in the presence of the partial agonist/antagonist RU486, while the lowest affinity (K(a) = 0.074 +/- 0.013 nM(-1)) was demonstrated with the full agonist 6alpha-methyl-16alpha,17alpha-cyclohexanoprogesterone.	Mifepristone	138-143	progesterone receptor	Rattus norvegicus	24-26
11958787-3	2002	The highest affinity of PR to DNA (equilibrium K(a) = 0.420 +/- 0.185 nM(-1)) was found in the presence of the partial agonist/antagonist RU486, while the lowest affinity (K(a) = 0.074 +/- 0.013 nM(-1)) was demonstrated with the full agonist 6alpha-methyl-16alpha,17alpha-cyclohexanoprogesterone.	6alpha-methyl-16alpha	242-263	progesterone receptor	Rattus norvegicus	24-26
11958787-3	2002	The highest affinity of PR to DNA (equilibrium K(a) = 0.420 +/- 0.185 nM(-1)) was found in the presence of the partial agonist/antagonist RU486, while the lowest affinity (K(a) = 0.074 +/- 0.013 nM(-1)) was demonstrated with the full agonist 6alpha-methyl-16alpha,17alpha-cyclohexanoprogesterone.	17alpha-cyclohexanoprogesterone	264-295	progesterone receptor	Rattus norvegicus	24-26
11859003-0	2002	Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.	6-aryl benzoxazines	79-98	progesterone receptor	Rattus norvegicus	20-41
11859003-1	2002	Novel 6-aryl benzoxazines were prepared and examined as progesterone receptor (PR) modulators.	6-aryl benzoxazines	6-25	progesterone receptor	Rattus norvegicus	56-77
11859003-1	2002	Novel 6-aryl benzoxazines were prepared and examined as progesterone receptor (PR) modulators.	6-aryl benzoxazines	6-25	progesterone receptor	Rattus norvegicus	79-81
11859003-2	2002	In contrast to the structurally related 6-aryl dihydroquinoline PR antagonists, the 6-aryl benzoxazines were potent PR agonists.	6-aryl benzoxazines	84-103	progesterone receptor	Rattus norvegicus	116-118
11859003-3	2002	Compounds 4e, 5b, and 6a with the 2,4,4-trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxazine core were the most potent PR agonists in the series with sub-nanomolar activities (EC(50) 0.20-0.35nM).	2,4,4-trimethyl-1,4-dihydro-2h-benzo[d][1,3]oxazine	34-85	progesterone receptor	Rattus norvegicus	112-114
11999716-3	2002	Both male and female pituitary protein extracts demonstrated an increase in nuclear protein binding activity to a progesterone receptor-oestrogen response element following oestradiol benzoate treatment.	estradiol 3-benzoate	173-192	progesterone receptor	Rattus norvegicus	114-135
11999716-6	2002	Oestradiol benzoate treatment also led to a significant increase in specific binding of hypothalamic nuclear proteins to the progesterone receptor oestrogen response element from both females and male hypothalamic extracts.	estradiol 3-benzoate	0-19	progesterone receptor	Rattus norvegicus	125-146
11804181-0	2001	Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea.	Methylnitrosourea	126-148	progesterone receptor	Rattus norvegicus	59-80
11804181-10	2001	All carcinomas from vorozole-treated rats expressed PR (2.5-60.2%) and correlation between ER and PR content was numerically greater in carcinomas from vorozole-treated animals (r = 0.42, p = 0.09).	vorozole	20-28	progesterone receptor	Rattus norvegicus	52-54
11804181-10	2001	All carcinomas from vorozole-treated rats expressed PR (2.5-60.2%) and correlation between ER and PR content was numerically greater in carcinomas from vorozole-treated animals (r = 0.42, p = 0.09).	vorozole	20-28	progesterone receptor	Rattus norvegicus	98-100
11804181-10	2001	All carcinomas from vorozole-treated rats expressed PR (2.5-60.2%) and correlation between ER and PR content was numerically greater in carcinomas from vorozole-treated animals (r = 0.42, p = 0.09).	vorozole	152-160	progesterone receptor	Rattus norvegicus	98-100
11748029-4	2001	Compared with controls, treatment with DES (10 microg) induced loss of epithelial and stromal androgen receptor (AR) immunoexpression coincident with induction of stromal progesterone receptor (PR) immunoexpression and upregulation of stromal immunoexpression of estrogen receptor-alpha (ERalpha).	Diethylstilbestrol	39-42	progesterone receptor	Rattus norvegicus	171-192
11748029-4	2001	Compared with controls, treatment with DES (10 microg) induced loss of epithelial and stromal androgen receptor (AR) immunoexpression coincident with induction of stromal progesterone receptor (PR) immunoexpression and upregulation of stromal immunoexpression of estrogen receptor-alpha (ERalpha).	Diethylstilbestrol	39-42	progesterone receptor	Rattus norvegicus	194-196
11748029-7	2001	Tamoxifen and flutamide induced PR and slightly upregulated ERalpha immunoexpression but had only a minor or no effect on AR expression and the stromal:epithelial ratio, though flutamide retarded normal development of the SVs.	Tamoxifen	0-9	progesterone receptor	Rattus norvegicus	32-34
11748029-7	2001	Tamoxifen and flutamide induced PR and slightly upregulated ERalpha immunoexpression but had only a minor or no effect on AR expression and the stromal:epithelial ratio, though flutamide retarded normal development of the SVs.	Flutamide	14-23	progesterone receptor	Rattus norvegicus	32-34
11474214-0	2001	The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats.	butylbenzyl phthalate	25-47	progesterone receptor	Rattus norvegicus	91-112
11566438-9	2001	The model was also used to evaluate trimegestone (TMG), a new steroidal progestin, that has been shown to be a potent and selective progesterone receptor agonist.	trimegestone	36-48	progesterone receptor	Rattus norvegicus	132-153
11566438-9	2001	The model was also used to evaluate trimegestone (TMG), a new steroidal progestin, that has been shown to be a potent and selective progesterone receptor agonist.	trimegestone	50-53	progesterone receptor	Rattus norvegicus	132-153
11474214-0	2001	The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats.	bisphenol A	52-63	progesterone receptor	Rattus norvegicus	91-112
11474214-6	2001	We also found that injection of BPA significantly increased PR mRNA in the POA and anterior pituitary, while injection of BBP increased PR mRNA in the POA and anterior pituitary, although the increase in the anterior pituitary was not significant.	bisphenol A	32-35	progesterone receptor	Rattus norvegicus	60-62
11218048-7	2001	EE2 increased messenger ribonucleic acid (mRNA) levels of uterine PR and induced peroxidase activity.	ribonucleic	24-35	progesterone receptor	Rattus norvegicus	66-68
11369298-5	2001	Correlation among the mRNA expression levels of PACAP, dPRP and the progesterone receptor and the coordinated inhibitory actions of the anti-progesterone (RU-486) suggest that there is also correlated time-dependent steroid regulation of the mRNA levels of PACAP, dPRP and the progesterone receptor in the decidual and pregnant uteri.	Mifepristone	155-161	progesterone receptor	Rattus norvegicus	68-89
11369298-5	2001	Correlation among the mRNA expression levels of PACAP, dPRP and the progesterone receptor and the coordinated inhibitory actions of the anti-progesterone (RU-486) suggest that there is also correlated time-dependent steroid regulation of the mRNA levels of PACAP, dPRP and the progesterone receptor in the decidual and pregnant uteri.	Mifepristone	155-161	progesterone receptor	Rattus norvegicus	277-298
11369298-5	2001	Correlation among the mRNA expression levels of PACAP, dPRP and the progesterone receptor and the coordinated inhibitory actions of the anti-progesterone (RU-486) suggest that there is also correlated time-dependent steroid regulation of the mRNA levels of PACAP, dPRP and the progesterone receptor in the decidual and pregnant uteri.	Steroids	216-223	progesterone receptor	Rattus norvegicus	68-89
11369298-5	2001	Correlation among the mRNA expression levels of PACAP, dPRP and the progesterone receptor and the coordinated inhibitory actions of the anti-progesterone (RU-486) suggest that there is also correlated time-dependent steroid regulation of the mRNA levels of PACAP, dPRP and the progesterone receptor in the decidual and pregnant uteri.	Steroids	216-223	progesterone receptor	Rattus norvegicus	277-298
11399792-8	2001	Estrogen stimulation of the TCDD-exposed glands induced progesterone receptor expression and mammary gland differentiation as measured by a shift in distribution from terminal end buds and terminal ducts to Types I and II lobules.	Polychlorinated Dibenzodioxins	28-32	progesterone receptor	Rattus norvegicus	56-77
11294976-11	2001	PR (B) was significantly increased by all injected doses of genistein or estrone and by the higher dietary dose (1000 mg genistein/kg AIN-76A).	Genistein	60-69	progesterone receptor	Rattus norvegicus	0-2
11294976-11	2001	PR (B) was significantly increased by all injected doses of genistein or estrone and by the higher dietary dose (1000 mg genistein/kg AIN-76A).	Estrone	73-80	progesterone receptor	Rattus norvegicus	0-2
11294976-11	2001	PR (B) was significantly increased by all injected doses of genistein or estrone and by the higher dietary dose (1000 mg genistein/kg AIN-76A).	Genistein	121-130	progesterone receptor	Rattus norvegicus	0-2
11294976-12	2001	PR (A) was significantly increased by injected doses of genistein (16.6 and 5.0 microg/g BW).	Genistein	56-65	progesterone receptor	Rattus norvegicus	0-2
11158625-0	2001	Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.	Dronabinol	61-89	progesterone receptor	Rattus norvegicus	0-21
11058452-9	2000	RU486, a progesterone receptor antagonist, enhanced supraoptic neurone Fos expression in late pregnancy, indicating progesterone receptor-mediated actions.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	9-30
11226710-7	2001	These results indicate a differential expression pattern of PR isoforms in the male rat brain and suggest that the tissue-specific expression of PR-A and PR-B is important for the appropriate response of each cerebral region to progesterone.	Progesterone	228-240	progesterone receptor	Rattus norvegicus	60-62
11058452-9	2000	RU486, a progesterone receptor antagonist, enhanced supraoptic neurone Fos expression in late pregnancy, indicating progesterone receptor-mediated actions.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	116-137
10385422-0	1999	Fluctuating estrogen and progesterone receptor expression in brainstem norepinephrine neurons through the rat estrous cycle.	Norepinephrine	71-85	progesterone receptor	Rattus norvegicus	25-46
11026564-7	2000	DES induction of PR immunoexpression was evident after a single injection (on day 3) and at 18-35 days the intensity of immunoexpression was DES dose-dependent; rats treated neonatally with 0.1 microg DES showed no detectable PR immunoexpression at any age.	desacetyluvaricin	0-3	progesterone receptor	Rattus norvegicus	226-228
11026564-11	2000	In DES-treated rats, immunoexpression of PR in the reproductive tract decreased progressively in intensity from days 18-35 and was non-detectable in adulthood.	desacetyluvaricin	3-6	progesterone receptor	Rattus norvegicus	41-43
10537124-3	1999	In estradiol-treated ovariectomized rats, approximately 80% of NT/neuromedin N mRNA-expressing cells in sections through the dorsomedial division of the ARC and approximately 60% of such cells in sections through the ventrolateral division of the ARC were found to contain PR mRNA.	Estradiol	3-12	progesterone receptor	Rattus norvegicus	273-275
10965915-0	2000	Progesterone regulation of the progesterone receptor in rat gonadotropes.	Progesterone	0-12	progesterone receptor	Rattus norvegicus	31-52
10965915-1	2000	For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone.	Progesterone	25-37	progesterone receptor	Rattus norvegicus	48-50
10965915-1	2000	For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone.	Progesterone	25-37	progesterone receptor	Rattus norvegicus	90-92
10965915-8	2000	RU486 completely blocked progesterone-induced PR down-regulation.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	46-48
10965915-10	2000	When cells were coincubated with progesterone and the proteasome inhibitor, MG132 (1 microM), the expected decrease in PR protein was abrogated.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	76-81	progesterone receptor	Rattus norvegicus	119-121
10965915-11	2000	In summary, progesterone leads to a rapid and extensive reduction in nuclear PR protein in gonadotropes.	Progesterone	12-24	progesterone receptor	Rattus norvegicus	77-79
10965915-14	2000	These dynamic changes in nuclear PR levels coincide with the temporal extent of the preovulatory LH surge in rats and could provide a basis for progesterone"s biphasic action on LH secretion.	Luteinizing Hormone	97-99	progesterone receptor	Rattus norvegicus	33-35
10965915-14	2000	These dynamic changes in nuclear PR levels coincide with the temporal extent of the preovulatory LH surge in rats and could provide a basis for progesterone"s biphasic action on LH secretion.	Luteinizing Hormone	178-180	progesterone receptor	Rattus norvegicus	33-35
10828856-7	2000	Treatment of rats during dioestrus and pro-oestrus with the specific antioestrogens LY117018 and RU58668 decreased the luteolytic effects of PRL and progesterone and the number of luteal endothelial cells immunostained for PR.	LY 117018	84-92	progesterone receptor	Rattus norvegicus	141-143
10828856-7	2000	Treatment of rats during dioestrus and pro-oestrus with the specific antioestrogens LY117018 and RU58668 decreased the luteolytic effects of PRL and progesterone and the number of luteal endothelial cells immunostained for PR.	RU 58668	97-104	progesterone receptor	Rattus norvegicus	141-143
11026564-7	2000	DES induction of PR immunoexpression was evident after a single injection (on day 3) and at 18-35 days the intensity of immunoexpression was DES dose-dependent; rats treated neonatally with 0.1 microg DES showed no detectable PR immunoexpression at any age.	desacetyluvaricin	0-3	progesterone receptor	Rattus norvegicus	17-19
10746653-16	2000	Immunohistochemistry confirmed the effectiveness of PR antisense oligonucleotides in blocking PR expression.	Oligonucleotides	65-81	progesterone receptor	Rattus norvegicus	94-96
10658644-6	2000	Since tetrahydroprogesterone does not bind to the progesterone receptor but is a ligand for the GABAA receptor, the hypothesis has been put forward that part of the steroidal effects reported might occur not through the classical progesterone receptor, but rather via an interaction with the GABAA receptor.	Allopregnanolone	6-28	progesterone receptor	Rattus norvegicus	230-251
10537148-2	1999	To further understand the molecular mechanism(s) by which PR plays a role critical for granulosa cell functions, we wanted to identify progesterone-induced genes in granulosa cells.	Progesterone	135-147	progesterone receptor	Rattus norvegicus	58-60
10537148-8	1999	This time difference in cAMP-responsive expression of the PR and PACAP genes is due, at least in part, to the requirement of ongoing protein synthesis for PACAP expression, as demonstrated by the inhibitory effect of cycloheximide on cAMP-induced PACAP, but not PR, mRNA levels.	Cyclic AMP	24-28	progesterone receptor	Rattus norvegicus	58-60
10537148-8	1999	This time difference in cAMP-responsive expression of the PR and PACAP genes is due, at least in part, to the requirement of ongoing protein synthesis for PACAP expression, as demonstrated by the inhibitory effect of cycloheximide on cAMP-induced PACAP, but not PR, mRNA levels.	Cyclic AMP	24-28	progesterone receptor	Rattus norvegicus	262-264
10537148-8	1999	This time difference in cAMP-responsive expression of the PR and PACAP genes is due, at least in part, to the requirement of ongoing protein synthesis for PACAP expression, as demonstrated by the inhibitory effect of cycloheximide on cAMP-induced PACAP, but not PR, mRNA levels.	Cycloheximide	217-230	progesterone receptor	Rattus norvegicus	58-60
10537148-8	1999	This time difference in cAMP-responsive expression of the PR and PACAP genes is due, at least in part, to the requirement of ongoing protein synthesis for PACAP expression, as demonstrated by the inhibitory effect of cycloheximide on cAMP-induced PACAP, but not PR, mRNA levels.	Cycloheximide	217-230	progesterone receptor	Rattus norvegicus	262-264
10537148-8	1999	This time difference in cAMP-responsive expression of the PR and PACAP genes is due, at least in part, to the requirement of ongoing protein synthesis for PACAP expression, as demonstrated by the inhibitory effect of cycloheximide on cAMP-induced PACAP, but not PR, mRNA levels.	Cyclic AMP	234-238	progesterone receptor	Rattus norvegicus	58-60
10537148-10	1999	This compound blocked cAMP-induced PACAP mRNA expression in a dose-dependent manner, indicating that PR activation is required for PACAP gene expression in granulosa cells.	Cyclic AMP	22-26	progesterone receptor	Rattus norvegicus	101-103
10526259-10	1999	Similarly, in a tamoxifen (0.03mg/kg)-treated group a decline was noticed in cytosolic ER with a mild increase in nuclear PR.	Tamoxifen	16-25	progesterone receptor	Rattus norvegicus	122-124
10526103-9	1999	The differential effects of progesterone may be due to differential expression of progesterone receptor isoforms or metabolites in specific brain areas suggesting that selective modulation of NMDA receptor-dependent epileptiform activity may play a role in hormonal effects on epileptogenesis.	Progesterone	28-40	progesterone receptor	Rattus norvegicus	82-103
10465261-5	1999	Treatment with estradiol (48 h) stimulated progesterone receptor (PR) messenger RNA expression and binding to [3H]R5020, a synthetic progestin.	Estradiol	15-24	progesterone receptor	Rattus norvegicus	43-64
10465261-5	1999	Treatment with estradiol (48 h) stimulated progesterone receptor (PR) messenger RNA expression and binding to [3H]R5020, a synthetic progestin.	Estradiol	15-24	progesterone receptor	Rattus norvegicus	66-68
10465261-5	1999	Treatment with estradiol (48 h) stimulated progesterone receptor (PR) messenger RNA expression and binding to [3H]R5020, a synthetic progestin.	Tritium	111-113	progesterone receptor	Rattus norvegicus	43-64
10465261-5	1999	Treatment with estradiol (48 h) stimulated progesterone receptor (PR) messenger RNA expression and binding to [3H]R5020, a synthetic progestin.	Tritium	111-113	progesterone receptor	Rattus norvegicus	66-68
10385422-7	1999	Experiments in ovariectomized, estrogen-treated and estrogen-plus progesterone-treated rats revealed that PR immunoreactivity in A2 neurons was induced strongly by estrogen treatment, whereas progesterone had no significant effect.	Progesterone	66-78	progesterone receptor	Rattus norvegicus	106-108
10381541-6	1999	It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region.	Dihydrotestosterone	85-88	progesterone receptor	Rattus norvegicus	49-51
10381541-6	1999	It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region.	Dihydrotestosterone	85-88	progesterone receptor	Rattus norvegicus	136-138
10381541-6	1999	It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region.	Steroids	194-201	progesterone receptor	Rattus norvegicus	49-51
10381541-6	1999	It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region.	Steroids	194-201	progesterone receptor	Rattus norvegicus	136-138
10494488-0	1999	Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites.	Norethindrone	101-115	progesterone receptor	Rattus norvegicus	14-35
10494488-2	1999	The aim of this work was to investigate the estrogenic properties of norethisterone (NET) and its A-ring-reduced derivatives by determining progesterone receptor (PR) and c-fos mRNA content of two estrogen-regulated genes in the uterus of ovariectomized rats.	Norethindrone	69-83	progesterone receptor	Rattus norvegicus	140-161
10494488-2	1999	The aim of this work was to investigate the estrogenic properties of norethisterone (NET) and its A-ring-reduced derivatives by determining progesterone receptor (PR) and c-fos mRNA content of two estrogen-regulated genes in the uterus of ovariectomized rats.	Norethindrone	69-83	progesterone receptor	Rattus norvegicus	163-165
10494488-4	1999	The highest PR and c-fos mRNA content was observed 3 h and 2 h after 17 beta-estradiol administration, respectively.	Estradiol	72-86	progesterone receptor	Rattus norvegicus	12-14
10218985-0	1999	Steroid regulation of progesterone receptor expression in cultured rat gonadotropes.	Steroids	0-7	progesterone receptor	Rattus norvegicus	22-43
10218985-3	1999	Northern blot of poly(A+) RNA extracts showed multiple PR messenger RNA (mRNA) transcripts between 4.8-10.2 kb; E2 treatment led to a 5- to 6-fold increase in the predominant PR mRNA transcripts (5.1 and 10.1 kb).	Poly A	17-25	progesterone receptor	Rattus norvegicus	55-57
10048465-0	1999	Cyclic GMP may potentiate lordosis behaviour by progesterone receptor activation.	Cyclic GMP	0-10	progesterone receptor	Rattus norvegicus	48-69
10048465-12	1999	RU486, a progesterone receptor antagonist, was used to assess whether the stimulatory effects of cGMP are mediated through the progesterone receptor.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	9-30
10048465-15	1999	These data show that cGMP facilitates lordosis through activation of PKG and the progesterone receptor.	Cyclic GMP	21-25	progesterone receptor	Rattus norvegicus	81-102
9870258-6	1998	The physiological role of progresterone in the induction of the preovulatory gonadotropin surge has been demonstrated by the attenuation of the progesterone-induced surge and the endogenous proestrus surge by progesterone receptor antagonist RU486 and the progesterone synthesis inhibitor trilostane.	progresterone	26-39	progesterone receptor	Rattus norvegicus	209-230
9926835-0	1998	Progesterone receptor isoforms are differentially regulated by sex steroids in the rat forebrain.	Steroids	67-75	progesterone receptor	Rattus norvegicus	0-21
9870258-6	1998	The physiological role of progresterone in the induction of the preovulatory gonadotropin surge has been demonstrated by the attenuation of the progesterone-induced surge and the endogenous proestrus surge by progesterone receptor antagonist RU486 and the progesterone synthesis inhibitor trilostane.	Mifepristone	242-247	progesterone receptor	Rattus norvegicus	209-230
9742655-13	1998	The androgen and progesterone receptor systems were less selective in that 17 beta-estradiol activated these systems within 3 orders of magnitude of the primary ligand.	Estradiol	75-92	progesterone receptor	Rattus norvegicus	17-38
9795281-0	1998	Interactions of 16alpha,17alpha-cyclohexane derivatives of progesterone with the progesterone receptor from rat uterus.	16alpha	16-23	progesterone receptor	Rattus norvegicus	81-102
9795281-0	1998	Interactions of 16alpha,17alpha-cyclohexane derivatives of progesterone with the progesterone receptor from rat uterus.	17alpha-cyclohexane	24-43	progesterone receptor	Rattus norvegicus	81-102
9795281-0	1998	Interactions of 16alpha,17alpha-cyclohexane derivatives of progesterone with the progesterone receptor from rat uterus.	Progesterone	59-71	progesterone receptor	Rattus norvegicus	81-102
9795281-1	1998	Pregna-D"-pentaranes, 16alpha,17alpha-cyclohexanoprogesterone and 6alpha-methyl-16alpha,17alpha-cyclohexanoprogestero ne, were found to specifically interact with the progesterone receptor of soluble fraction from rat uterus.	pregna-d"-pentaranes	0-20	progesterone receptor	Rattus norvegicus	167-188
9795281-1	1998	Pregna-D"-pentaranes, 16alpha,17alpha-cyclohexanoprogesterone and 6alpha-methyl-16alpha,17alpha-cyclohexanoprogestero ne, were found to specifically interact with the progesterone receptor of soluble fraction from rat uterus.	17alpha-cyclohexanoprogesterone	30-61	progesterone receptor	Rattus norvegicus	167-188
9795281-1	1998	Pregna-D"-pentaranes, 16alpha,17alpha-cyclohexanoprogesterone and 6alpha-methyl-16alpha,17alpha-cyclohexanoprogestero ne, were found to specifically interact with the progesterone receptor of soluble fraction from rat uterus.	6alpha-methyl-16alpha	66-87	progesterone receptor	Rattus norvegicus	167-188
9717846-1	1998	Expression of progesterone receptor (PR) mRNA in granulosa cells of ovarian preovulatory follicles is induced by LH (1, 2) and is essential for ovulation (3).	Luteinizing Hormone	113-115	progesterone receptor	Rattus norvegicus	14-35
9717846-1	1998	Expression of progesterone receptor (PR) mRNA in granulosa cells of ovarian preovulatory follicles is induced by LH (1, 2) and is essential for ovulation (3).	Luteinizing Hormone	113-115	progesterone receptor	Rattus norvegicus	37-39
9717846-2	1998	Although 17beta-estradiol (E) can induce PR mRNA and activate PR promoter-reporter constructs in other cell types, the effects of E in granulosa cells appear to be indirect.	Estradiol	9-25	progesterone receptor	Rattus norvegicus	41-43
9717846-2	1998	Although 17beta-estradiol (E) can induce PR mRNA and activate PR promoter-reporter constructs in other cell types, the effects of E in granulosa cells appear to be indirect.	Estradiol	9-25	progesterone receptor	Rattus norvegicus	62-64
9717846-4	1998	Rather, induction of PR mRNA depends on the differentiation of granulosa cells in response to E and a physiological amount of FSH followed by exposure to agonists (elevated levels of LH, FSH, and forskolin) that markedly increase cAMP.	Luteinizing Hormone	183-185	progesterone receptor	Rattus norvegicus	21-23
9717846-4	1998	Rather, induction of PR mRNA depends on the differentiation of granulosa cells in response to E and a physiological amount of FSH followed by exposure to agonists (elevated levels of LH, FSH, and forskolin) that markedly increase cAMP.	Colforsin	196-205	progesterone receptor	Rattus norvegicus	21-23
9717846-4	1998	Rather, induction of PR mRNA depends on the differentiation of granulosa cells in response to E and a physiological amount of FSH followed by exposure to agonists (elevated levels of LH, FSH, and forskolin) that markedly increase cAMP.	Cyclic AMP	230-234	progesterone receptor	Rattus norvegicus	21-23
9717846-5	1998	Induction of PR mRNA by forskolin is blocked by the A-kinase inhibitor H89 and cycloheximide but not by the E antagonist, ICI 164,384.	Colforsin	24-33	progesterone receptor	Rattus norvegicus	13-15
9717846-5	1998	Induction of PR mRNA by forskolin is blocked by the A-kinase inhibitor H89 and cycloheximide but not by the E antagonist, ICI 164,384.	Cycloheximide	79-92	progesterone receptor	Rattus norvegicus	13-15
9717846-7	1998	When distal and proximal PR promoter-reporter constructs that are responsive to E in other cell types were transiently transfected into differentiated granulosa cells, forskolin, but not E, induced activity.	Colforsin	168-177	progesterone receptor	Rattus norvegicus	25-27
9717846-11	1998	The GC-rich region of the distal PR promoter bound Sp1 and Sp3 but not C/EBPalpha/beta, indicating that factors binding to ERE3 interact synergistically with Sp1/Sp3 to confer increased responsiveness of the distal promoter to forskolin.	Colforsin	227-236	progesterone receptor	Rattus norvegicus	33-35
9780328-6	1998	Furthermore, blocking progesterone actions with progesterone receptor antagonists RU-486 or ZK98299 without affecting PRL secretion inhibited apoptosis but did not affect the accumulation of macrophages, whether treatment was started on the morning of metestrus (blocking diestrous and proestrous progesterone) or on proestrus (blocking only proestrous progesterone).	Mifepristone	82-88	progesterone receptor	Rattus norvegicus	48-69
9863568-4	1998	The distribution studies revealed that PR-mediated uptake in the uterus and ovaries could only be demonstrated for Z-[123I]IPG2.	z-[123i]ipg2	115-127	progesterone receptor	Rattus norvegicus	39-41
9863568-8	1998	Mammary tumour uptake of Z-[123I]IPG2 in the mammary tumour-bearing rat was also found to be PR-specific.	z-[123i]ipg2	25-37	progesterone receptor	Rattus norvegicus	93-95
9863568-10	1998	In conclusion, Z-[123I]IPG2, which displayed high binding affinity for both the human and rat PR in vitro, showed specific PR-mediated target tissue uptake in rats and rabbits in vivo, the uptake selectivity being highest in the latter.	z-[123i]ipg2	15-27	progesterone receptor	Rattus norvegicus	94-96
9863568-10	1998	In conclusion, Z-[123I]IPG2, which displayed high binding affinity for both the human and rat PR in vitro, showed specific PR-mediated target tissue uptake in rats and rabbits in vivo, the uptake selectivity being highest in the latter.	z-[123i]ipg2	15-27	progesterone receptor	Rattus norvegicus	123-125
9603245-2	1998	These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486.	Steroids	18-25	progesterone receptor	Rattus norvegicus	79-100
9603245-2	1998	These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486.	Steroids	18-25	progesterone receptor	Rattus norvegicus	102-104
9603245-2	1998	These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486.	Mifepristone	118-124	progesterone receptor	Rattus norvegicus	79-100
9603245-2	1998	These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486.	Mifepristone	118-124	progesterone receptor	Rattus norvegicus	102-104
9603252-0	1998	Regulation of the progesterone receptor and estrogen receptor in decidua basalis by progesterone and estradiol during pregnancy.	Estradiol	101-110	progesterone receptor	Rattus norvegicus	18-39
9165013-1	1997	Previous in vivo studies from our laboratory indicated that administration of the antiprogestin RU486 on proestrus suppresses both the preovulatory gonadotropin surges and the secondary FSH surge, suggesting a role for the progesterone receptor (PR) in the generation of these surges.	Mifepristone	96-101	progesterone receptor	Rattus norvegicus	223-244
9644551-0	1998	[Interaction of 16alpha,17alpha-cyclopropanoprogesterone with progesterone receptor of the rat uterus].	16alpha	16-23	progesterone receptor	Rattus norvegicus	62-83
9644551-0	1998	[Interaction of 16alpha,17alpha-cyclopropanoprogesterone with progesterone receptor of the rat uterus].	17alpha-cyclopropanoprogesterone	24-56	progesterone receptor	Rattus norvegicus	62-83
9389575-8	1997	Uterine, vaginal and tumoral estrogen and progesterone receptor levels were reduced markedly following treatment with EM-800.	EM 800	118-124	progesterone receptor	Rattus norvegicus	42-63
9459197-6	1997	Treatment of ovariectomized rats with estradiol resulted in high PR levels in the myometrium and stroma cells but low PR immunoreactivity in the epithelial cells.	Estradiol	38-47	progesterone receptor	Rattus norvegicus	65-67
9459197-6	1997	Treatment of ovariectomized rats with estradiol resulted in high PR levels in the myometrium and stroma cells but low PR immunoreactivity in the epithelial cells.	Estradiol	38-47	progesterone receptor	Rattus norvegicus	118-120
9459197-7	1997	The ER-mediated repression of the PR immunoreactivity was evidently restricted to the uterine epithelium, as we found that in the epithelial cells of the mammary gland and in cells of N-nitrosomethylurea-induced mammary carcinomas the PR expression was induced by estrogens and was blocked by the pure antiestrogen ZM 182780.	Fulvestrant	315-324	progesterone receptor	Rattus norvegicus	34-36
9328167-9	1997	Simvastatin feeding produced an increased development of ER- PgR- tumours and a reduced incidence of ER+ PgR+ tumours.	Simvastatin	0-11	progesterone receptor	Rattus norvegicus	61-64
9328167-9	1997	Simvastatin feeding produced an increased development of ER- PgR- tumours and a reduced incidence of ER+ PgR+ tumours.	Simvastatin	0-11	progesterone receptor	Rattus norvegicus	105-108
9389534-1	1997	Progesterone receptor (PR) messenger RNA (mRNA) is concentrated in neurons of the preoptic area and other regions of the rat hypothalamus where it is colocalized with the estrogen receptor and regulated by changes in the steroid hormonal milieu.	Steroids	221-228	progesterone receptor	Rattus norvegicus	0-21
9389534-1	1997	Progesterone receptor (PR) messenger RNA (mRNA) is concentrated in neurons of the preoptic area and other regions of the rat hypothalamus where it is colocalized with the estrogen receptor and regulated by changes in the steroid hormonal milieu.	Steroids	221-228	progesterone receptor	Rattus norvegicus	23-25
9389534-3	1997	The present studies used in situ hybridization to ascertain the time course of PR mRNA regulation in the medial preoptic nucleus by 17beta-estradiol, determine the effective dose required to elicit a response, and compare the efficacy of 17beta-estradiol with a variety of estrogenic or antiestrogenic compounds.	Estradiol	132-148	progesterone receptor	Rattus norvegicus	79-81
9389534-4	1997	The first series of studies revealed that the treatment of ovariectomized rats with 17beta-estradiol resulted in an increase in PR expression within 2 h, after which it remained elevated until 10 h postinjection and then returned to baseline levels.	Estradiol	84-100	progesterone receptor	Rattus norvegicus	128-130
9389534-5	1997	When ovariectomized rats were injected with 25-1000 ng/kg of 17beta-estradiol and euthanized 6 h later, a dose-dependent increase in the level of PR mRNA was observed, with a maximal response at 1000 ng/kg and an EC50 of 93.5 ng/kg.	Estradiol	61-77	progesterone receptor	Rattus norvegicus	146-148
9389534-7	1997	17Beta-estradiol, diethylstilbestrol, and 17alpha-estradiol all significantly increased the level of PR mRNA, although the degree of induction varied with each compound.	Estradiol	0-16	progesterone receptor	Rattus norvegicus	101-103
9389534-7	1997	17Beta-estradiol, diethylstilbestrol, and 17alpha-estradiol all significantly increased the level of PR mRNA, although the degree of induction varied with each compound.	Diethylstilbestrol	18-36	progesterone receptor	Rattus norvegicus	101-103
9389534-7	1997	17Beta-estradiol, diethylstilbestrol, and 17alpha-estradiol all significantly increased the level of PR mRNA, although the degree of induction varied with each compound.	alfatradiol	42-59	progesterone receptor	Rattus norvegicus	101-103
9389534-9	1997	In contrast, when tamoxifen or raloxifene, but not ICI 182,780, was administered in the antagonist mode, a significant dose-related decrease in the estradiol-induced level of PR mRNA was seen in the preoptic area.	Tamoxifen	18-27	progesterone receptor	Rattus norvegicus	175-177
9389534-9	1997	In contrast, when tamoxifen or raloxifene, but not ICI 182,780, was administered in the antagonist mode, a significant dose-related decrease in the estradiol-induced level of PR mRNA was seen in the preoptic area.	Raloxifene Hydrochloride	31-41	progesterone receptor	Rattus norvegicus	175-177
9389534-9	1997	In contrast, when tamoxifen or raloxifene, but not ICI 182,780, was administered in the antagonist mode, a significant dose-related decrease in the estradiol-induced level of PR mRNA was seen in the preoptic area.	Estradiol	148-157	progesterone receptor	Rattus norvegicus	175-177
9389534-10	1997	The results of these studies clearly demonstrate that PR mRNA expression in the rat preoptic area is rapidly stimulated by a small dose of 17beta-estradiol.	Estradiol	139-155	progesterone receptor	Rattus norvegicus	54-56
9165013-1	1997	Previous in vivo studies from our laboratory indicated that administration of the antiprogestin RU486 on proestrus suppresses both the preovulatory gonadotropin surges and the secondary FSH surge, suggesting a role for the progesterone receptor (PR) in the generation of these surges.	Mifepristone	96-101	progesterone receptor	Rattus norvegicus	246-248
8921337-11	1996	For instance, the full estrogen receptor antagonist ICI decreased ER (to almost 0) and PR levels, but has no uterotrophic effects, while TAM decreases ER (to almost 0) and increases PR with uterotrophic effects.	Tamoxifen	137-140	progesterone receptor	Rattus norvegicus	182-184
8961269-9	1996	Finally, cocaine facilitation of behavior was blocked by both antiprogestin RU486 and progesterone receptor AS microinjected into either the third ventricle or the VMN.	Cocaine	9-16	progesterone receptor	Rattus norvegicus	86-107
8961269-10	1996	Collectively, the data provide strong evidence for cocaine modulation of reproductive behavior through presynaptic cocaine-sensitive dopamine transporters and postsynaptic D5 dopamine receptor mediation of progesterone receptor-dependent behavior in rat central nervous system.	Cocaine	51-58	progesterone receptor	Rattus norvegicus	206-227
8922878-3	1996	In the present study the affinity of drospirenone to the progesterone receptor (PR), the androgen receptor (AR), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), and the estrogen receptor (ER) was re-evaluated by steroid binding assays and compared to those obtained for the natural hormone progesterone.	drospirenone	37-49	progesterone receptor	Rattus norvegicus	57-78
8922878-3	1996	In the present study the affinity of drospirenone to the progesterone receptor (PR), the androgen receptor (AR), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), and the estrogen receptor (ER) was re-evaluated by steroid binding assays and compared to those obtained for the natural hormone progesterone.	drospirenone	37-49	progesterone receptor	Rattus norvegicus	80-82
8922878-4	1996	Drospirenone displayed high affinity to PR and MR and low binding to AR, similar to progesterone.	drospirenone	0-12	progesterone receptor	Rattus norvegicus	40-42
8853395-1	1996	Previous studies have demonstrated antiglucocorticoid actions for the progesterone receptor antagonist RU-486.	Mifepristone	103-109	progesterone receptor	Rattus norvegicus	70-91
8845038-0	1996	Vinclozolin does not alter progesterone receptor (PR) function in vivo despite inhibition of PR binding by its metabolites in vitro.	vinclozolin	0-11	progesterone receptor	Rattus norvegicus	93-95
8845038-3	1996	As steroid hormone receptors exhibit promiscuity in their ability to bind different ligands, the present study evaluated the ability of these vinclozolin metabolites to bind to the estrogen (ER) and progesterone (PR) receptors in vitro, and to alter ER and PR function following in vivo exposure.	vinclozolin	142-153	progesterone receptor	Rattus norvegicus	213-215
8845038-6	1996	Subsequent in vivo studies to evaluate the potential of vinclozolin to alter ER or PR function demonstrate that, (1) the estrogen-dependent increases in uterine weight and PR induction were not altered by vinclozolin; (2) the distribution of nuclear and cytosolic PR was not altered following short-term vinclozolin exposure; and (3) vinclozolin did not disrupt ovulation in cycling female rats.	vinclozolin	56-67	progesterone receptor	Rattus norvegicus	83-85
8845038-7	1996	These studies indicate that although vinclozolin metabolites can compete for binding to the PR in vitro, concentrations of these metabolites do not reach sufficient levels to disrupt female reproductive function following short-term in vivo exposure to vinclozolin.	vinclozolin	37-48	progesterone receptor	Rattus norvegicus	92-94
9275423-1	1996	OBJECTIVE: To study the influence of subdermal implantation of levonorgestrel (LNG) on the levels of estradiol receptor (ER) and progesterone receptor (PR) in ovaries and endometrium of rats.	Levonorgestrel	63-77	progesterone receptor	Rattus norvegicus	129-150
9275423-1	1996	OBJECTIVE: To study the influence of subdermal implantation of levonorgestrel (LNG) on the levels of estradiol receptor (ER) and progesterone receptor (PR) in ovaries and endometrium of rats.	Levonorgestrel	63-77	progesterone receptor	Rattus norvegicus	152-154
9275423-1	1996	OBJECTIVE: To study the influence of subdermal implantation of levonorgestrel (LNG) on the levels of estradiol receptor (ER) and progesterone receptor (PR) in ovaries and endometrium of rats.	Levonorgestrel	79-82	progesterone receptor	Rattus norvegicus	129-150
9275423-1	1996	OBJECTIVE: To study the influence of subdermal implantation of levonorgestrel (LNG) on the levels of estradiol receptor (ER) and progesterone receptor (PR) in ovaries and endometrium of rats.	Levonorgestrel	79-82	progesterone receptor	Rattus norvegicus	152-154
8932736-0	1996	Ovarian steroid regulation of estrogen and progesterone receptor messenger ribonucleic acid in the anteroventral periventricular nucleus of the rat.	Steroids	8-15	progesterone receptor	Rattus norvegicus	43-64
8756415-1	1996	To characterize the signaling pathway by which the neurotransmitter dopamine modulates progesterone receptor (PR) activation, the steroid-dependent behavior lordosis was used in estrogen-primed ovariectomized Sprague-Dawley rats with stereotaxic implanted third ventricle cannulas.	Dopamine	68-76	progesterone receptor	Rattus norvegicus	87-108
8756415-1	1996	To characterize the signaling pathway by which the neurotransmitter dopamine modulates progesterone receptor (PR) activation, the steroid-dependent behavior lordosis was used in estrogen-primed ovariectomized Sprague-Dawley rats with stereotaxic implanted third ventricle cannulas.	Dopamine	68-76	progesterone receptor	Rattus norvegicus	110-112
8756415-8	1996	Finally, facilitation of sex behavior by D1-like agonists was blocked by the antiprogestin RU38486 and PR antisense oligonucleotide.	Oligonucleotides	116-131	progesterone receptor	Rattus norvegicus	103-105
8886628-0	1996	Blockade of the estrogen induced increase in progesterone receptor caused by propylthiouracil, an anti-thyroid drug, in a transplantable pituitary tumor in rats.	Propylthiouracil	77-93	progesterone receptor	Rattus norvegicus	45-66
8886628-4	1996	When the host rats were treated with propylthiouracil (PTU), an anti-thyroid drug, the induction of PR after an E2 injection was completely blocked.	Propylthiouracil	37-53	progesterone receptor	Rattus norvegicus	100-102
8886628-4	1996	When the host rats were treated with propylthiouracil (PTU), an anti-thyroid drug, the induction of PR after an E2 injection was completely blocked.	Propylthiouracil	55-58	progesterone receptor	Rattus norvegicus	100-102
8886628-10	1996	Our findings suggest that PTU lower the ER level and suppresses the short term estrogenic actions such as PR induction after an E2 injection.	Propylthiouracil	26-29	progesterone receptor	Rattus norvegicus	106-108
8734471-2	1996	In this report, we show that progesterone receptor (PR), in the presence of progesterone (P) directly represses rat gonadotropin releasing hormone (rGnRH) gene transcription.	Progesterone	29-41	progesterone receptor	Rattus norvegicus	52-54
8734471-5	1996	Cotransfection of a mutant progesterone receptor that lacks a functional DNA binding region (hPRcys) abolished repression of the rGnRH promoter by P. Gel mobility shift assays confirmed that PR directly binds to the DNA fragments -171/-126, -126/-73, and -111/-73, which encompass the negative progesterone response element (nPRE) of the rGnRH promoter.	Progesterone	27-39	progesterone receptor	Rattus norvegicus	94-96
8758696-1	1996	The effect of L-TYR on rat uterine cytosol estradiol and progesterone receptor contents was studied.	Tyrosine	14-19	progesterone receptor	Rattus norvegicus	57-78
8758696-7	1996	Threonine could also decrease, to some extent, the uterine cytosol progesterone receptor content at estrus and dioestrus phases.	Threonine	0-9	progesterone receptor	Rattus norvegicus	67-88
8758696-9	1996	The present observation indicates that L-TYR appears to affect the synthesis of the cytosol estradiol and progesterone receptor in the rat uterus independent, however, of endogenous ovarian sex hormones, since the effect is still present in the ovariectomized animals.	Tyrosine	39-44	progesterone receptor	Rattus norvegicus	106-127
7857875-1	1995	In previous studies, we observed that aromatase inhibitor 4-hydroxy-androstenedione (4-OHA) treatment significantly decreased estrogen (ER) and progesterone receptor (PR) concentrations in the uterus of ovariectomized (OVX) rats.	formestane	58-83	progesterone receptor	Rattus norvegicus	144-165
7588292-0	1995	Cis-regulatory elements conferring cyclic 3",5"-adenosine monophosphate responsiveness of the progesterone receptor gene in transfected rat granulosa cells.	cyclic 3",5"-adenosine monophosphate	35-71	progesterone receptor	Rattus norvegicus	94-115
7588292-1	1995	We have previously shown that both pituitary gonadotropins and forskolin induce progesterone receptor (PR) messenger RNA expression at the level of transcription in granulosa cells of the rat ovary.	Colforsin	63-72	progesterone receptor	Rattus norvegicus	80-101
7588292-1	1995	We have previously shown that both pituitary gonadotropins and forskolin induce progesterone receptor (PR) messenger RNA expression at the level of transcription in granulosa cells of the rat ovary.	Colforsin	63-72	progesterone receptor	Rattus norvegicus	103-105
7588292-2	1995	To determine the DNA regulatory elements that are important for cAMP-induced transcription of the PR gene in the ovary, we examined the cAMP-induced activity of promoter sequences in rat granulosa cells transfected with various fusion constructs containing PRB promoter sequences linked to the luciferase reporter gene.	Cyclic AMP	64-68	progesterone receptor	Rattus norvegicus	98-100
7503800-1	1995	Treatment of immature 21-day-old female Sprague-Dawley rats with 17 beta-estradiol (E2) (0.5 microgram/rat) caused a significant increase in uterine wet weight, DNA synthesis, progesterone receptor (PR) binding, and peroxidase activity.	Estradiol	65-82	progesterone receptor	Rattus norvegicus	176-197
7503800-1	1995	Treatment of immature 21-day-old female Sprague-Dawley rats with 17 beta-estradiol (E2) (0.5 microgram/rat) caused a significant increase in uterine wet weight, DNA synthesis, progesterone receptor (PR) binding, and peroxidase activity.	Estradiol	65-82	progesterone receptor	Rattus norvegicus	199-201
7503800-1	1995	Treatment of immature 21-day-old female Sprague-Dawley rats with 17 beta-estradiol (E2) (0.5 microgram/rat) caused a significant increase in uterine wet weight, DNA synthesis, progesterone receptor (PR) binding, and peroxidase activity.	Estradiol	84-86	progesterone receptor	Rattus norvegicus	176-197
7503800-1	1995	Treatment of immature 21-day-old female Sprague-Dawley rats with 17 beta-estradiol (E2) (0.5 microgram/rat) caused a significant increase in uterine wet weight, DNA synthesis, progesterone receptor (PR) binding, and peroxidase activity.	Estradiol	84-86	progesterone receptor	Rattus norvegicus	199-201
7503800-3	1995	However, in rats cotreated with E2 (0.5 microgram/rat) plus naringenin (30 mg/rat); there was a significant decrease in E2-induced uterine wet weight, DNA synthesis, PR binding, and peroxidase activity, indicating that naringenin exhibits antiestrogenic activity in the immature rodent uterus.	naringenin	60-70	progesterone receptor	Rattus norvegicus	166-168
7581174-1	1995	We have evaluated 6 alpha-[18F]fluoroprogesterone as a potential imaging agent for progesterone receptor (PgR)-positive breast cancer.	alpha-[18f]fluoroprogesterone	20-49	progesterone receptor	Rattus norvegicus	83-104
7581174-1	1995	We have evaluated 6 alpha-[18F]fluoroprogesterone as a potential imaging agent for progesterone receptor (PgR)-positive breast cancer.	alpha-[18f]fluoroprogesterone	20-49	progesterone receptor	Rattus norvegicus	106-109
7581174-3	1995	The relative binding affinity (RBA) of 6 alpha-fluoroprogesterone (1) to PgR is 11 (R5020 = 100), and its binding selectivity index (BSI, i.e. the ratio of the RBA to the non-specific binding, NSB) is 14.4; these values are similar to those of progesterone.	alpha-fluoroprogesterone	41-65	progesterone receptor	Rattus norvegicus	73-76
7581174-3	1995	The relative binding affinity (RBA) of 6 alpha-fluoroprogesterone (1) to PgR is 11 (R5020 = 100), and its binding selectivity index (BSI, i.e. the ratio of the RBA to the non-specific binding, NSB) is 14.4; these values are similar to those of progesterone.	Progesterone	53-65	progesterone receptor	Rattus norvegicus	73-76
7581174-4	1995	17 alpha-Acetoxy-6 alpha-fluoroprogesterone (2) was also prepared by the same method, but was not used for fluorine-18 labeling studies because its binding affinity for PgR is very low (0.9).	17 alpha-acetoxy-6 alpha-fluoroprogesterone	0-43	progesterone receptor	Rattus norvegicus	169-172
7750284-3	1995	In the present study the affinity of gestodene to the progesterone receptor (PR), the androgen receptor (AR), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR) and the estrogen receptor (ER) was re-evaluated by steroid binding assays and compared to those obtained for 3-keto-desogestrel and progesterone.	Gestodene	37-46	progesterone receptor	Rattus norvegicus	54-75
7750284-3	1995	In the present study the affinity of gestodene to the progesterone receptor (PR), the androgen receptor (AR), the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR) and the estrogen receptor (ER) was re-evaluated by steroid binding assays and compared to those obtained for 3-keto-desogestrel and progesterone.	Gestodene	37-46	progesterone receptor	Rattus norvegicus	77-79
8603037-6	1996	The induction of DNA-binding and transcriptional activation of the progesterone receptor requires intracellular oxidation of the neurosteroids into progesterone receptor-active 5 alpha-pregnane steroids.	alpha-pregnane steroids	179-202	progesterone receptor	Rattus norvegicus	67-88
8603037-6	1996	The induction of DNA-binding and transcriptional activation of the progesterone receptor requires intracellular oxidation of the neurosteroids into progesterone receptor-active 5 alpha-pregnane steroids.	alpha-pregnane steroids	179-202	progesterone receptor	Rattus norvegicus	148-169
7534703-6	1995	To determine whether the lack of PR mRNA in the rat CL is due to progesterone-induced down-regulation of PR mRNA or to low levels of estrogen, aminoglutethimide was used to block the synthesis of progesterone in the presence and absence of exogenous estrogen, and PR mRNA levels were examined in the CL as well as the placenta.	Progesterone	65-77	progesterone receptor	Rattus norvegicus	105-107
7534703-6	1995	To determine whether the lack of PR mRNA in the rat CL is due to progesterone-induced down-regulation of PR mRNA or to low levels of estrogen, aminoglutethimide was used to block the synthesis of progesterone in the presence and absence of exogenous estrogen, and PR mRNA levels were examined in the CL as well as the placenta.	Progesterone	65-77	progesterone receptor	Rattus norvegicus	105-107
7857875-1	1995	In previous studies, we observed that aromatase inhibitor 4-hydroxy-androstenedione (4-OHA) treatment significantly decreased estrogen (ER) and progesterone receptor (PR) concentrations in the uterus of ovariectomized (OVX) rats.	formestane	58-83	progesterone receptor	Rattus norvegicus	167-169
7857875-1	1995	In previous studies, we observed that aromatase inhibitor 4-hydroxy-androstenedione (4-OHA) treatment significantly decreased estrogen (ER) and progesterone receptor (PR) concentrations in the uterus of ovariectomized (OVX) rats.	formestane	85-90	progesterone receptor	Rattus norvegicus	144-165
7857875-1	1995	In previous studies, we observed that aromatase inhibitor 4-hydroxy-androstenedione (4-OHA) treatment significantly decreased estrogen (ER) and progesterone receptor (PR) concentrations in the uterus of ovariectomized (OVX) rats.	formestane	85-90	progesterone receptor	Rattus norvegicus	167-169
7857875-3	1995	After 2 weeks of 4-OHA treatment both ER and PR were reduced in mammary tumors, as well as in uteri of intact animals (P < 0.05).	formestane	17-22	progesterone receptor	Rattus norvegicus	45-47
7857875-6	1995	Treatment of OVX rats with estradiol (0.2 microgram/ml) restored tumor PR concentrations to the level of the control, whereas ER levels were increased to concentrations slightly higher than the control.	Estradiol	27-36	progesterone receptor	Rattus norvegicus	71-73
7857875-10	1995	Treatment with 4-OHA reduced mRNA levels of ER and PR in uterus and tumors in intact and OVX animals.	formestane	15-20	progesterone receptor	Rattus norvegicus	51-53
7857875-11	1995	Levels of tumor mRNA of both ER and PR were inhibited by 4-OHA treatment in estradiol treated OVX rats.	formestane	57-62	progesterone receptor	Rattus norvegicus	36-38
7857875-11	1995	Levels of tumor mRNA of both ER and PR were inhibited by 4-OHA treatment in estradiol treated OVX rats.	Estradiol	76-85	progesterone receptor	Rattus norvegicus	36-38
7857875-12	1995	Thus, 4-OHA appears to inhibit ER and PR concentrations in mammary tumors of the rat by reducing transcription.	formestane	6-11	progesterone receptor	Rattus norvegicus	38-40
8089603-13	1994	4) Primate monkey studies: SHR, especially PR, was localized mostly in the preoptic hypothalamic region and hypophysis in contrast with its wide distribution in the rat brain, suggesting the more limited feedback site of progesterone in women.	Progesterone	221-233	progesterone receptor	Rattus norvegicus	43-45
7925102-0	1994	Inhibition of rat sexual behavior by antisense oligonucleotides to the progesterone receptor.	Oligonucleotides	47-63	progesterone receptor	Rattus norvegicus	71-92
7925102-4	1994	In vitro binding assays of the cytosol progesterone receptors demonstrated a 52.2% reduction of PRs in the hypothalamus of animals that received antisense oligonucleotides, suggesting a reduction in PR synthesis.	Oligonucleotides	155-171	progesterone receptor	Rattus norvegicus	96-98
7925102-5	1994	These data suggest that a threshold level of estrogen-induced hypothalamic PR is critical in the regulation of progesterone-facilitated sexual behavior in female rats.	Progesterone	111-123	progesterone receptor	Rattus norvegicus	75-77
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	Atrazine	27-35	progesterone receptor	Rattus norvegicus	91-112
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	Simazine	37-45	progesterone receptor	Rattus norvegicus	91-112
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	diaminochlorotriazine	50-54	progesterone receptor	Rattus norvegicus	91-112
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	Estradiol	214-223	progesterone receptor	Rattus norvegicus	91-112
7932848-7	1994	Oral doses of 300 mg/kg of atrazine, simazine, or DACT significantly reduced expression of progesterone receptor binding in cytosol fractions prepared from uteri of ovariectomized rats injected sc with 1 microgram estradiol; 50 mg/kg triazine was not effective in this case.	Triazines	234-242	progesterone receptor	Rattus norvegicus	91-112
7915049-4	1994	The facilitory effect of the neurotransmitter was blocked by progesterone receptor antagonists, a D1 receptor antagonist, or antisense oligonucleotides to the progesterone receptor.	Oligonucleotides	135-151	progesterone receptor	Rattus norvegicus	159-180
8126569-3	1994	When applied 12 but not 24 hr after estradiol, the PR antisense treatment significantly reduced iordosis behavior, measured either as a reflex or in a mating behavior test.	Estradiol	36-45	progesterone receptor	Rattus norvegicus	51-53
7984148-3	1994	We found that a pulse of GnRH administered to gonadotrope-enriched pituitary cells cultured in medium containing charcoal-treated serum plus estradiol (E2) potentiated the LH secretory response to subsequent GnRH pulses, and this potentiation could be blocked by a PR antagonist, RU486, in the absence of progesterone.	Estradiol	141-150	progesterone receptor	Rattus norvegicus	265-267
7984148-3	1994	We found that a pulse of GnRH administered to gonadotrope-enriched pituitary cells cultured in medium containing charcoal-treated serum plus estradiol (E2) potentiated the LH secretory response to subsequent GnRH pulses, and this potentiation could be blocked by a PR antagonist, RU486, in the absence of progesterone.	Luteinizing Hormone	172-174	progesterone receptor	Rattus norvegicus	265-267
7984148-5	1994	To directly test whether stimulation with either GnRH or a cAMP analog results in transactivation of the endogenous PR, we used rat anterior pituitary cells cultured in the presence of E2 and transfected with reporter plasmids containing progesterone-responsive elements (PRE) and either a E1b or a thymidine kinase (tk) promoter linked to the chloramphenicol acetyltransferase (CAT) gene.	Cyclic AMP	59-63	progesterone receptor	Rattus norvegicus	116-118
7984148-12	1994	A simple interpretation of these data is that a GnRH-triggered signaling cascade can result in progesterone-independent transactivation of the PR.	Progesterone	95-107	progesterone receptor	Rattus norvegicus	143-145
8019941-0	1994	Protooncogene, growth factor, growth factor receptor, and estrogen and progesterone receptor gene expression in the immature rat uterus after treatment with estrogen and tamoxifen.	Tamoxifen	170-179	progesterone receptor	Rattus norvegicus	71-92
8243259-12	1993	Our results demonstrate that 1) NPY facilitates LHRH-induced LH surges on the afternoon of proestrus; 2) presumptive progesterone receptor blockade by RU486 completely prevents NPY"s potentiating effects; and 3) NPY is without effect on the morning of proestrus, before the afternoon surge of progesterone.	Mifepristone	151-156	progesterone receptor	Rattus norvegicus	117-138
8299566-0	1994	Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3",5"-monophosphate in rat granulosa cells.	Cyclic AMP	66-102	progesterone receptor	Rattus norvegicus	18-39
8299566-3	1994	Gonadotropins also effectively induce PR mRNA expression in primary cultures of rat granulosa cells, and this action can be mimicked by agents that elevate intracellular cAMP (forskolin or 8-bromo-cAMP).	Cyclic AMP	170-174	progesterone receptor	Rattus norvegicus	38-40
8299566-3	1994	Gonadotropins also effectively induce PR mRNA expression in primary cultures of rat granulosa cells, and this action can be mimicked by agents that elevate intracellular cAMP (forskolin or 8-bromo-cAMP).	Colforsin	176-185	progesterone receptor	Rattus norvegicus	38-40
8299566-3	1994	Gonadotropins also effectively induce PR mRNA expression in primary cultures of rat granulosa cells, and this action can be mimicked by agents that elevate intracellular cAMP (forskolin or 8-bromo-cAMP).	8-Bromo Cyclic Adenosine Monophosphate	189-201	progesterone receptor	Rattus norvegicus	38-40
8299566-5	1994	The cAMP-induced PR mRNA expression in rat granulosa cells is blocked by an inhibitor of transcription, but not by an inhibitor of protein synthesis.	Cyclic AMP	4-8	progesterone receptor	Rattus norvegicus	17-19
8299566-7	1994	However, when luciferase fusion genes containing a 1375-basepair rat PR gene promoter were transiently transfected into rat granulosa cells, luciferase activity could be stimulated several-fold by hCG or forskolin, but not by estrogen.	Colforsin	204-213	progesterone receptor	Rattus norvegicus	69-71
8299566-8	1994	These results indicate that gonadotropins, most likely acting through a pathway mediated by cAMP, are able to stimulate transcription of the PR gene in rat granulosa cells and suggest a mechanism for regulating the intraovarian actions of progesterone.	Cyclic AMP	92-96	progesterone receptor	Rattus norvegicus	141-143
8299566-8	1994	These results indicate that gonadotropins, most likely acting through a pathway mediated by cAMP, are able to stimulate transcription of the PR gene in rat granulosa cells and suggest a mechanism for regulating the intraovarian actions of progesterone.	Progesterone	239-251	progesterone receptor	Rattus norvegicus	141-143
8169558-5	1994	The cell-specific distribution of these proteins was determined in the rat uterus during early pregnancy and after injection of the progesterone receptor antagonist mifepristone (RU 486) at days 1 and 2 post coitum (p.c.)	Mifepristone	165-177	progesterone receptor	Rattus norvegicus	132-153
8243259-4	1993	On proestrus, hourly blood samples were collected from 1100-2100 h. At 1230 h, rats received a sc injection of the progesterone receptor antagonist RU486 (6 mg/kg BW) or oil.	Mifepristone	148-153	progesterone receptor	Rattus norvegicus	115-136
8245220-11	1993	(7) Treatment of intact rats with the progesterone receptor antagonist, RU 486, during the proestrus phase of the estrous cycle inhibits the proestrus to estrus drop in spine density.	Mifepristone	72-78	progesterone receptor	Rattus norvegicus	38-59
8300755-8	1993	The intensity of the PR but not the RBF-1 staining was markedly down-regulated in these cells at 2 and 6 h after treatment of the animals with progesterone (P).	Progesterone	143-155	progesterone receptor	Rattus norvegicus	21-23
7693394-1	1993	The antigestagen mifepristone (RU 486) acts by blocking the progesterone receptor.	Mifepristone	17-29	progesterone receptor	Rattus norvegicus	60-81
7693394-1	1993	The antigestagen mifepristone (RU 486) acts by blocking the progesterone receptor.	Mifepristone	31-37	progesterone receptor	Rattus norvegicus	60-81
8344215-2	1993	The present study was undertaken to determine the effects of various agonists (LH, FSH, forskolin, and GnRH) known to stimulate ovulation on their abilities to induce progesterone receptor (PR) mRNA and protein in rat preovulatory follicles and in cultured rat granulosa cells exhibiting a preovulatory phenotype.	Colforsin	88-97	progesterone receptor	Rattus norvegicus	167-188
8344215-2	1993	The present study was undertaken to determine the effects of various agonists (LH, FSH, forskolin, and GnRH) known to stimulate ovulation on their abilities to induce progesterone receptor (PR) mRNA and protein in rat preovulatory follicles and in cultured rat granulosa cells exhibiting a preovulatory phenotype.	Colforsin	88-97	progesterone receptor	Rattus norvegicus	190-192
8344215-9	1993	These results provide direct evidence that agonists stimulating diverse intracellular pathways can induce PR in granulosa cells, that progesterone plays a functional role in the luteinization process triggered by the LH surge, and that the effects are mediated at least in part by induction of PR.	Progesterone	134-146	progesterone receptor	Rattus norvegicus	294-296
1317780-5	1992	In rat anterior pituitary cells cultured in the absence of progesterone, it was found that the progesterone receptor antagonist RU486 (2 nM) inhibits LHRH self-potentiation induced by hourly pulses of 1 nM LHRH.	Mifepristone	128-133	progesterone receptor	Rattus norvegicus	95-116
8504742-2	1993	In the present study, we used immature ovariectomized rats to examine the regulation of PR gene expression and growth in the uterus by estradiol (E2) as well as hormonal modulators of E2 action, namely progesterone (P), the antiestrogen LY117018 (LY), and the antiprogestin RU486.	Estradiol	135-144	progesterone receptor	Rattus norvegicus	88-90
1493716-6	1992	Sucrose density gradient centrifugation of the 3H-dihydrospirorenone-labeled myometrial cytosol showed that the dihydrospirorenone binding components sedimented in the 4S and 8S region which is typical for the progesterone receptor under low salt conditions.	3h-dihydrospirorenone	47-68	progesterone receptor	Rattus norvegicus	210-231
1390280-0	1992	Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus.	Danazol	35-42	progesterone receptor	Rattus norvegicus	0-21
1390280-3	1992	Uteri from danazol-treated rats showed a doubling of progesterone receptor concentrations compared with the control uteri.	Danazol	11-18	progesterone receptor	Rattus norvegicus	53-74
8361336-1	1993	Antisense oligonucleotides were utilized to interfere with the synthesis of progesterone receptor.	Oligonucleotides	10-26	progesterone receptor	Rattus norvegicus	76-97
1353410-5	1992	Carcinomas induced by neu in ovariectomized rats had down-regulated estrogen receptor and progesterone receptor, while those induced by ras had only down-regulated progesterone receptor.	Ethylnitrosourea	22-25	progesterone receptor	Rattus norvegicus	90-111
1584221-9	1992	When added in combination with E2, TAM acted as a classical antiestrogen, partially blocking the induction of PR by E2.	Tamoxifen	35-38	progesterone receptor	Rattus norvegicus	110-112
1584221-10	1992	To determine whether the inabilities of TAM to stimulate cell proliferation and induce PR were a function of TAM concentration, dose-response experiments were performed.	Tamoxifen	40-43	progesterone receptor	Rattus norvegicus	87-89
1584221-11	1992	TAM at concentrations ranging from 10(-8)-10(-6) M was effective in inducing PRL mRNA, but at none of the tested concentrations was TAM effective in stimulating cell proliferation or inducing PR.	Tamoxifen	0-3	progesterone receptor	Rattus norvegicus	77-79
1562510-3	1992	Although the roles of progesterone and the progesterone receptor in control of cell growth remain unclear, it was found in progesterone receptor positive mammary carcinoma cell lines that the antiprogestin, Mifepristone, had an inhibitory effect on cell growth and a growth-inhibiting action on the DMBA-induced mammary carcinoma of the rat.	Mifepristone	207-219	progesterone receptor	Rattus norvegicus	43-64
1562510-3	1992	Although the roles of progesterone and the progesterone receptor in control of cell growth remain unclear, it was found in progesterone receptor positive mammary carcinoma cell lines that the antiprogestin, Mifepristone, had an inhibitory effect on cell growth and a growth-inhibiting action on the DMBA-induced mammary carcinoma of the rat.	Mifepristone	207-219	progesterone receptor	Rattus norvegicus	123-144
1313194-1	1992	Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in uterine wet weight and cytosolic and nuclear estrogen receptor (ER) and progesterone receptor (PR) levels in immature female Sprague-Dawley rats.	6-nitro-1,3,8-trichlorodibenzofuran	18-53	progesterone receptor	Rattus norvegicus	181-202
1313194-1	1992	Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in uterine wet weight and cytosolic and nuclear estrogen receptor (ER) and progesterone receptor (PR) levels in immature female Sprague-Dawley rats.	6-nitro-1,3,8-trichlorodibenzofuran	18-53	progesterone receptor	Rattus norvegicus	204-206
1313194-1	1992	Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in uterine wet weight and cytosolic and nuclear estrogen receptor (ER) and progesterone receptor (PR) levels in immature female Sprague-Dawley rats.	6-nitro-1,3,8-trichlorodibenzofuran	55-61	progesterone receptor	Rattus norvegicus	181-202
1313194-1	1992	Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in uterine wet weight and cytosolic and nuclear estrogen receptor (ER) and progesterone receptor (PR) levels in immature female Sprague-Dawley rats.	6-nitro-1,3,8-trichlorodibenzofuran	55-61	progesterone receptor	Rattus norvegicus	204-206
1313194-4	1992	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity.	Polychlorinated Dibenzodioxins	0-35	progesterone receptor	Rattus norvegicus	230-232
1313194-4	1992	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity.	Polychlorinated Dibenzodioxins	37-41	progesterone receptor	Rattus norvegicus	230-232
1313194-4	1992	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), which exhibits a broad spectrum of antiestrogenic effects in the female rat uterus, inhibited the 17 beta-estradiol-induced increase in uterine wet weights, cytosolic and nuclear ER and PR levels, peroxidase activity, and EGF receptor binding activity.	Estradiol	145-159	progesterone receptor	Rattus norvegicus	230-232
1958508-1	1991	The antiprogestin RU486 has been shown to inhibit the growth of a number of tumor cell lines and solid tumors which contain significant concentrations of progesterone receptor (PgR).	Mifepristone	18-23	progesterone receptor	Rattus norvegicus	154-175
1958508-1	1991	The antiprogestin RU486 has been shown to inhibit the growth of a number of tumor cell lines and solid tumors which contain significant concentrations of progesterone receptor (PgR).	Mifepristone	18-23	progesterone receptor	Rattus norvegicus	177-180
1958508-7	1991	RU486 treatment alone suppressed PgR content and resulted in only insignificant inhibition of growth.	Mifepristone	0-5	progesterone receptor	Rattus norvegicus	33-36
1958508-8	1991	However, when significant PgR concentrations were maintained by combined treatment with DES, RU486 significantly suppressed tumor growth (0.01 less than P less than 0.05 vs controls).	Diethylstilbestrol	88-91	progesterone receptor	Rattus norvegicus	26-29
1958508-8	1991	However, when significant PgR concentrations were maintained by combined treatment with DES, RU486 significantly suppressed tumor growth (0.01 less than P less than 0.05 vs controls).	Mifepristone	93-98	progesterone receptor	Rattus norvegicus	26-29
1839136-0	1991	Inhibition of the tocolytic activity of atrial natriuretic factor by progesterone and potentiation by progesterone receptor antagonist RU486 in rats.	Mifepristone	135-140	progesterone receptor	Rattus norvegicus	102-123
1664743-3	1991	This study examined whether the inhibition of uterine contraction by progesterone and its metabolites was progesterone receptor-mediated or gamma amino butyric acidA (GABAA) receptor-mediated.	Progesterone	69-81	progesterone receptor	Rattus norvegicus	106-127
1874194-1	1991	In this study we have examined the effect of population density on the ability of 17 beta-estradiol (E2) to induce PRL mRNA, DNA synthesis, and progesterone receptor in GH4C1 pituitary tumor cells.	Estradiol	82-99	progesterone receptor	Rattus norvegicus	144-165
1664743-9	1991	The effect of 5 beta-pregnane-3,20-dione and progesterone was effectively blocked by RU486 but not by picrotoxin, suggesting that their actions were mediated through the progesterone receptor system.	5-alpha-Dihydroprogesterone	14-40	progesterone receptor	Rattus norvegicus	170-191
1664743-9	1991	The effect of 5 beta-pregnane-3,20-dione and progesterone was effectively blocked by RU486 but not by picrotoxin, suggesting that their actions were mediated through the progesterone receptor system.	Progesterone	45-57	progesterone receptor	Rattus norvegicus	170-191
1664743-9	1991	The effect of 5 beta-pregnane-3,20-dione and progesterone was effectively blocked by RU486 but not by picrotoxin, suggesting that their actions were mediated through the progesterone receptor system.	Mifepristone	85-90	progesterone receptor	Rattus norvegicus	170-191
1926229-2	1991	Scatchard plot analysis of the equilibrium binding data showed that [3H]NOM-Ac binds to uterine PgR with a Kd of 5.44 +/- 1.27 nM and a Bmax of 1.51 +/- 0.11 pmol/mg protein.	Tritium	69-71	progesterone receptor	Rattus norvegicus	96-99
1884369-0	1991	Preclinical evaluation of a positron emitting progestin ([18F]fluoro-16 alpha-methyl-19-norprogesterone) for imaging progesterone receptor positive tumours with positron emission tomography.	fluoro-16 alpha-methyl-19-norprogesterone	62-103	progesterone receptor	Rattus norvegicus	117-138
1840636-3	1991	We used the polymerase chain reaction to clone the steroid-binding domain of the rat PR from uterine cDNA and used this as a probe to isolate a larger cDNA from a rat placental cDNA library.	Steroids	51-58	progesterone receptor	Rattus norvegicus	85-87
1840636-13	1991	This transient, hormonally regulated, and cell-specific expression of the PR gene in the rat ovary strongly suggests an important intraovarian function for progesterone during the rat reproductive cycle.	Progesterone	156-168	progesterone receptor	Rattus norvegicus	74-76
1926229-3	1991	Analysis of dissociation kinetics showed that [3H]NOM-Ac dissociates slowly from the PgR, k - 1 = 4.9 +/- 0.5 10(-5) s-1.	Tritium	47-49	progesterone receptor	Rattus norvegicus	85-88
1706263-7	1991	Although estrogen, cAMP, and insulin-like growth factor I (IGF-I) may act via different pathways to increase PR, the effects evoked by maximally effective concentrations of these agents are not additive implying involvement of a common component.	Cyclic AMP	19-23	progesterone receptor	Rattus norvegicus	109-111
1706263-8	1991	The increases in PR evoked by estradiol, cAMP, or IGF-I are markedly suppressed by treatment with antiestrogen (ICI 164,384) or the cyclic nucleotide-dependent protein kinase inhibitor H8 or the protein kinase A inhibitor PKI, indicating the involvement of the estrogen receptor and phosphorylation pathways in PR regulation by these three agents.	Estradiol	30-39	progesterone receptor	Rattus norvegicus	17-19
1706263-0	1991	Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3",5"-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitors.	Cyclic AMP	76-112	progesterone receptor	Rattus norvegicus	0-21
1706263-8	1991	The increases in PR evoked by estradiol, cAMP, or IGF-I are markedly suppressed by treatment with antiestrogen (ICI 164,384) or the cyclic nucleotide-dependent protein kinase inhibitor H8 or the protein kinase A inhibitor PKI, indicating the involvement of the estrogen receptor and phosphorylation pathways in PR regulation by these three agents.	Estradiol	30-39	progesterone receptor	Rattus norvegicus	311-313
1706263-3	1991	In these primary cultures of uterine cells isolated from 19-day-old immature rats, 8-bromo-cAMP evokes significant increases in PR by 8 h with maximal increases by 24 h. This time course and magnitude of PR stimulation are similar to those evoked by maximally effective concentrations of estradiol (3 x 10(-9) M) or IGF-I (20 ng/ml).	8-Bromo Cyclic Adenosine Monophosphate	83-95	progesterone receptor	Rattus norvegicus	128-130
1706263-3	1991	In these primary cultures of uterine cells isolated from 19-day-old immature rats, 8-bromo-cAMP evokes significant increases in PR by 8 h with maximal increases by 24 h. This time course and magnitude of PR stimulation are similar to those evoked by maximally effective concentrations of estradiol (3 x 10(-9) M) or IGF-I (20 ng/ml).	8-Bromo Cyclic Adenosine Monophosphate	83-95	progesterone receptor	Rattus norvegicus	204-206
1706263-8	1991	The increases in PR evoked by estradiol, cAMP, or IGF-I are markedly suppressed by treatment with antiestrogen (ICI 164,384) or the cyclic nucleotide-dependent protein kinase inhibitor H8 or the protein kinase A inhibitor PKI, indicating the involvement of the estrogen receptor and phosphorylation pathways in PR regulation by these three agents.	Cyclic AMP	41-45	progesterone receptor	Rattus norvegicus	17-19
1706263-8	1991	The increases in PR evoked by estradiol, cAMP, or IGF-I are markedly suppressed by treatment with antiestrogen (ICI 164,384) or the cyclic nucleotide-dependent protein kinase inhibitor H8 or the protein kinase A inhibitor PKI, indicating the involvement of the estrogen receptor and phosphorylation pathways in PR regulation by these three agents.	Cyclic AMP	41-45	progesterone receptor	Rattus norvegicus	311-313
1706263-9	1991	The present studies identify cAMP, as well as estrogen and IGF-I, as important regulators of the level of PR in uterine cells and suggest that multiple factors, including those affecting intracellular cAMP levels, might influence responsiveness to progestins via regulation of the intracellular PR content.	Cyclic AMP	29-33	progesterone receptor	Rattus norvegicus	106-108
1706263-9	1991	The present studies identify cAMP, as well as estrogen and IGF-I, as important regulators of the level of PR in uterine cells and suggest that multiple factors, including those affecting intracellular cAMP levels, might influence responsiveness to progestins via regulation of the intracellular PR content.	Cyclic AMP	29-33	progesterone receptor	Rattus norvegicus	295-297
1706263-9	1991	The present studies identify cAMP, as well as estrogen and IGF-I, as important regulators of the level of PR in uterine cells and suggest that multiple factors, including those affecting intracellular cAMP levels, might influence responsiveness to progestins via regulation of the intracellular PR content.	Cyclic AMP	201-205	progesterone receptor	Rattus norvegicus	106-108
2068588-4	1991	Furthermore, administration of tyrosine to the uterine lumen decreased significantly the contents of progesterone receptor in proestrus, oestrus and diestrus, but not in metestrus.	Tyrosine	31-39	progesterone receptor	Rattus norvegicus	101-122
2068588-5	1991	It is suggested that tyrosine might exert a certain regulatory influence on the progesterone receptor content in rat uterine endometrium.	Tyrosine	21-29	progesterone receptor	Rattus norvegicus	80-101
2090671-1	1990	19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR).	19-norprogesterone	0-19	progesterone receptor	Rattus norvegicus	114-117
1995287-4	1991	A "9 S" PR was observed in the cytosol and a "4-5 S" PR was found in the nuclear high salt, tungstate ions containing extract of estradiol-treated cells.	Salts	86-90	progesterone receptor	Rattus norvegicus	53-55
1995287-4	1991	A "9 S" PR was observed in the cytosol and a "4-5 S" PR was found in the nuclear high salt, tungstate ions containing extract of estradiol-treated cells.	tungstate	92-101	progesterone receptor	Rattus norvegicus	53-55
1995287-4	1991	A "9 S" PR was observed in the cytosol and a "4-5 S" PR was found in the nuclear high salt, tungstate ions containing extract of estradiol-treated cells.	Estradiol	129-138	progesterone receptor	Rattus norvegicus	53-55
1995287-5	1991	When the antiprogestin [3H]RU486 was used instead of [3H]R5020 as a ligand, a 9 S PR was also found in the cytosol, but a nonactivated "8.5 S" receptor complex was identified in the high salt nuclear fraction in presence of tungstate ions.	Tritium	24-26	progesterone receptor	Rattus norvegicus	82-84
1995287-5	1991	When the antiprogestin [3H]RU486 was used instead of [3H]R5020 as a ligand, a 9 S PR was also found in the cytosol, but a nonactivated "8.5 S" receptor complex was identified in the high salt nuclear fraction in presence of tungstate ions.	Mifepristone	27-32	progesterone receptor	Rattus norvegicus	82-84
1995287-5	1991	When the antiprogestin [3H]RU486 was used instead of [3H]R5020 as a ligand, a 9 S PR was also found in the cytosol, but a nonactivated "8.5 S" receptor complex was identified in the high salt nuclear fraction in presence of tungstate ions.	Tritium	54-56	progesterone receptor	Rattus norvegicus	82-84
1995287-6	1991	The levels of PR, as measured by whole cell assay, were significantly increased when glial cells were cultured in the presence of 50 nM estradiol, as compared to nonestradiol-treated controls.	Estradiol	136-145	progesterone receptor	Rattus norvegicus	14-16
1995287-6	1991	The levels of PR, as measured by whole cell assay, were significantly increased when glial cells were cultured in the presence of 50 nM estradiol, as compared to nonestradiol-treated controls.	nonestradiol	162-174	progesterone receptor	Rattus norvegicus	14-16
1995287-7	1991	The estrogen induction of PR was suppressed by the antiestrogen tamoxifen, but tamoxifen by itself had no effect on PR concentration.	Tamoxifen	64-73	progesterone receptor	Rattus norvegicus	26-28
1995287-9	1991	The PR was visualized inside glial cells by immunohistochemical studies with a monoclonal antibody specific for the B-form of PR (KC 146), which was recognized by fluorescein-linked or biotinylated secondary antibodies.	Fluorescein	163-174	progesterone receptor	Rattus norvegicus	4-6
1995287-11	1991	This is the first demonstration of PR in rat glial cells, and we present evidence of its induction by estradiol in primary cultures.	Estradiol	102-111	progesterone receptor	Rattus norvegicus	35-37
1825621-11	1991	These results suggest that the effect of histidine on ER and PgR levels is probably specific for tumour tissue and is not due to a direct activity.	Histidine	41-50	progesterone receptor	Rattus norvegicus	61-64
1949047-2	1991	Treatment of the animals with 17 beta-estradiol (0.33 mumol/kg X 2) caused an increase in uterine cytosolic and nuclear estrogen and progesterone receptor levels, uterine peroxidase activity, uterine wet weights and uterine epidermal growth factor (EGF) receptor binding activity and steady state EGF receptor mRNA levels.	Estradiol	30-47	progesterone receptor	Rattus norvegicus	133-154
2090671-1	1990	19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR).	19-norprogesterone	0-19	progesterone receptor	Rattus norvegicus	91-112
1848992-6	1991	Treatment of OVX rats with 17 beta-estradiol (E2) alone or in combination with progesterone (P) caused a highly significant increase in beta-adrenergic and progesterone receptor levels, as well as tumor growth.	Estradiol	27-44	progesterone receptor	Rattus norvegicus	156-177
1848992-6	1991	Treatment of OVX rats with 17 beta-estradiol (E2) alone or in combination with progesterone (P) caused a highly significant increase in beta-adrenergic and progesterone receptor levels, as well as tumor growth.	Progesterone	79-91	progesterone receptor	Rattus norvegicus	156-177
1848992-11	1991	The positive correlation observed between changes in beta-adrenergic receptor concentration, progesterone receptor levels and tumor growth indicates a high sensitivity of the beta-adrenergic receptor population of DMBA-induced rat mammary tumors to the hormonal milieu, and suggests that the beta-adrenergic receptor system may represent a valuable parameter of hormone responsiveness.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	214-218	progesterone receptor	Rattus norvegicus	93-114
2090671-1	1990	19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR).	19-norprogesterone	21-25	progesterone receptor	Rattus norvegicus	91-112
2090671-1	1990	19-nor-progesterone (19NP) is a potent progestagen which possesses a high affinity for the progesterone receptor (PgR).	19-norprogesterone	21-25	progesterone receptor	Rattus norvegicus	114-117
2090671-7	1990	Strikingly, the protection of the free 17 alpha-hydroxyl group of NOM by an acetate led to a potent progestin with high affinity for PgR.	Acetates	76-83	progesterone receptor	Rattus norvegicus	133-136
2263962-0	1990	[The comparison of the binding of Ru486 to progesterone receptor of pituitary and endometrium in ovariectomized rat].	Mifepristone	34-39	progesterone receptor	Rattus norvegicus	43-64
2128946-0	1990	Estrogen and progesterone receptor levels in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in each week--check points about experimental studies using DMBA-induced tumors.	7,12-dimethylbenz	45-62	progesterone receptor	Rattus norvegicus	13-34
2128946-0	1990	Estrogen and progesterone receptor levels in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in each week--check points about experimental studies using DMBA-induced tumors.	anthracene	65-75	progesterone receptor	Rattus norvegicus	13-34
2128946-0	1990	Estrogen and progesterone receptor levels in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in each week--check points about experimental studies using DMBA-induced tumors.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	163-167	progesterone receptor	Rattus norvegicus	13-34
2128782-6	1990	After treatment, the estrogen receptor (ER) and progesterone receptor (PgR) levels decreased significantly in the groups treated with TAM alone and the combination of 5-FU and TAM but remained unchanged in the group treated with 5-FU alone.	Tamoxifen	134-137	progesterone receptor	Rattus norvegicus	48-69
2128782-6	1990	After treatment, the estrogen receptor (ER) and progesterone receptor (PgR) levels decreased significantly in the groups treated with TAM alone and the combination of 5-FU and TAM but remained unchanged in the group treated with 5-FU alone.	Tamoxifen	134-137	progesterone receptor	Rattus norvegicus	71-74
2128782-6	1990	After treatment, the estrogen receptor (ER) and progesterone receptor (PgR) levels decreased significantly in the groups treated with TAM alone and the combination of 5-FU and TAM but remained unchanged in the group treated with 5-FU alone.	Fluorouracil	167-171	progesterone receptor	Rattus norvegicus	48-69
2128782-6	1990	After treatment, the estrogen receptor (ER) and progesterone receptor (PgR) levels decreased significantly in the groups treated with TAM alone and the combination of 5-FU and TAM but remained unchanged in the group treated with 5-FU alone.	Fluorouracil	167-171	progesterone receptor	Rattus norvegicus	71-74
2128782-6	1990	After treatment, the estrogen receptor (ER) and progesterone receptor (PgR) levels decreased significantly in the groups treated with TAM alone and the combination of 5-FU and TAM but remained unchanged in the group treated with 5-FU alone.	Tamoxifen	176-179	progesterone receptor	Rattus norvegicus	71-74
2128782-7	1990	The decreases in the ER and PgR levels in responsive tumors after treatment were considerably greater in the groups greated with TAM alone and the combination of 5-FU and TAM than in the group treated with 5-FU alone.	Tamoxifen	129-132	progesterone receptor	Rattus norvegicus	28-31
2128782-7	1990	The decreases in the ER and PgR levels in responsive tumors after treatment were considerably greater in the groups greated with TAM alone and the combination of 5-FU and TAM than in the group treated with 5-FU alone.	Fluorouracil	162-166	progesterone receptor	Rattus norvegicus	28-31
2128782-7	1990	The decreases in the ER and PgR levels in responsive tumors after treatment were considerably greater in the groups greated with TAM alone and the combination of 5-FU and TAM than in the group treated with 5-FU alone.	Tamoxifen	171-174	progesterone receptor	Rattus norvegicus	28-31
2128782-7	1990	The decreases in the ER and PgR levels in responsive tumors after treatment were considerably greater in the groups greated with TAM alone and the combination of 5-FU and TAM than in the group treated with 5-FU alone.	Fluorouracil	206-210	progesterone receptor	Rattus norvegicus	28-31
2263962-2	1990	Thirty minutes after administration of Ru486 (2 mg/kg) the binding sites of progesterone receptor in both tissues showed a significant initial decrease, and then gradually reached the lowest level in 2 h. Afterwards the levels of progesterone receptor began to increase.	Mifepristone	39-44	progesterone receptor	Rattus norvegicus	76-97
2263962-2	1990	Thirty minutes after administration of Ru486 (2 mg/kg) the binding sites of progesterone receptor in both tissues showed a significant initial decrease, and then gradually reached the lowest level in 2 h. Afterwards the levels of progesterone receptor began to increase.	Mifepristone	39-44	progesterone receptor	Rattus norvegicus	230-251
2263962-3	1990	The results suggested that Ru486 could interact with progesterone receptor in both tissues.	Mifepristone	27-32	progesterone receptor	Rattus norvegicus	53-74
2263962-4	1990	However, the binding ability of Ru486 for different tissue was not exactly the same, and Ru486 binding to the progesterone receptor in endometrium might be easier.	Mifepristone	89-94	progesterone receptor	Rattus norvegicus	110-131
2326286-5	1990	Danazol also increased pituitary progesterone receptor levels, an estrogen-sensitive end point.	Danazol	0-7	progesterone receptor	Rattus norvegicus	33-54
2156667-14	1990	The progesterone receptor antagonist RU486 administered alone had no effect on serum LH or FSH levels.	Mifepristone	37-42	progesterone receptor	Rattus norvegicus	4-25
2289744-1	1990	The characteristics of binding (Kinetic and equilibrium binding analysis) of nomegestrol acetate (NOM, 17 alpha-acetoxy-6 alpha-methyl-19-nor-pregna-4.6-diene-3.20-dione) to the progesterone receptor (PgR) in rat uterine cytosolic fraction were determined in comparison to progesterone (P), to fully appreciate the amplitude and specificity of the induced biological response.	nomegestrol acetate	77-96	progesterone receptor	Rattus norvegicus	178-199
2289744-1	1990	The characteristics of binding (Kinetic and equilibrium binding analysis) of nomegestrol acetate (NOM, 17 alpha-acetoxy-6 alpha-methyl-19-nor-pregna-4.6-diene-3.20-dione) to the progesterone receptor (PgR) in rat uterine cytosolic fraction were determined in comparison to progesterone (P), to fully appreciate the amplitude and specificity of the induced biological response.	nomegestrol acetate	77-96	progesterone receptor	Rattus norvegicus	201-204
2289744-1	1990	The characteristics of binding (Kinetic and equilibrium binding analysis) of nomegestrol acetate (NOM, 17 alpha-acetoxy-6 alpha-methyl-19-nor-pregna-4.6-diene-3.20-dione) to the progesterone receptor (PgR) in rat uterine cytosolic fraction were determined in comparison to progesterone (P), to fully appreciate the amplitude and specificity of the induced biological response.	.6-diene-3.20-dione	150-169	progesterone receptor	Rattus norvegicus	178-199
1690881-1	1990	The R3327 HI experimental prostatic carcinoma was serially transplanted through six generations of castrated host rats to examine changes in the capacity to synthesize progesterone receptor (PgR) in response to diethylstilbestrol (DES) stimulation during progression from a well-differentiated state containing a significant stromal component to a poorly differentiated state with virtually no stroma.	Diethylstilbestrol	211-229	progesterone receptor	Rattus norvegicus	168-189
2341287-2	1990	Two of these are fluorine-substituted analogs of the potent progestin R5020 (promegestone), derived from (21S)-hydroxy R 5020 (RU 27987) and (21R)-hydroxy R 5020 (RU 27988), known metabolites of R 5020, which have affinities for PgR that are 116 and 4%, respectively (relative to R 5020 = 100%).	Fluorine	17-25	progesterone receptor	Rattus norvegicus	229-232
2341287-2	1990	Two of these are fluorine-substituted analogs of the potent progestin R5020 (promegestone), derived from (21S)-hydroxy R 5020 (RU 27987) and (21R)-hydroxy R 5020 (RU 27988), known metabolites of R 5020, which have affinities for PgR that are 116 and 4%, respectively (relative to R 5020 = 100%).	Promegestone	77-89	progesterone receptor	Rattus norvegicus	229-232
2341287-4	1990	Fluoride ion displacement, followed by acid-catalyzed deprotection, furnished in good yield the epimeric fluoroanalogs, (21S)- and (21R)-fluro R 5020 (1 and 2, affinities for PgR, 11 and 45%, respectively).	Fluorides	0-8	progesterone receptor	Rattus norvegicus	175-178
1690881-1	1990	The R3327 HI experimental prostatic carcinoma was serially transplanted through six generations of castrated host rats to examine changes in the capacity to synthesize progesterone receptor (PgR) in response to diethylstilbestrol (DES) stimulation during progression from a well-differentiated state containing a significant stromal component to a poorly differentiated state with virtually no stroma.	Diethylstilbestrol	211-229	progesterone receptor	Rattus norvegicus	191-194
1690881-1	1990	The R3327 HI experimental prostatic carcinoma was serially transplanted through six generations of castrated host rats to examine changes in the capacity to synthesize progesterone receptor (PgR) in response to diethylstilbestrol (DES) stimulation during progression from a well-differentiated state containing a significant stromal component to a poorly differentiated state with virtually no stroma.	Diethylstilbestrol	231-234	progesterone receptor	Rattus norvegicus	168-189
1690881-1	1990	The R3327 HI experimental prostatic carcinoma was serially transplanted through six generations of castrated host rats to examine changes in the capacity to synthesize progesterone receptor (PgR) in response to diethylstilbestrol (DES) stimulation during progression from a well-differentiated state containing a significant stromal component to a poorly differentiated state with virtually no stroma.	Diethylstilbestrol	231-234	progesterone receptor	Rattus norvegicus	191-194
1690881-3	1990	The capacity for PgR synthesis in response to DES treatment fell progressively, but did not reach statistical significance during the first four generations.	Diethylstilbestrol	46-49	progesterone receptor	Rattus norvegicus	17-20
3613575-0	1987	Estradiol-induced progesterone receptor synthesis in normal and diabetic ovariectomized rat uterus.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	18-39
9283049-0	1997	Progesterone receptor participates in the stimulatory effect of LHRH, prostaglandin E2, and cyclic AMP on lordosis and proceptive behaviours in rats.	Dinoprostone	70-86	progesterone receptor	Rattus norvegicus	0-21
9283049-0	1997	Progesterone receptor participates in the stimulatory effect of LHRH, prostaglandin E2, and cyclic AMP on lordosis and proceptive behaviours in rats.	Cyclic AMP	92-102	progesterone receptor	Rattus norvegicus	0-21
9283049-3	1997	Results suggest that the estrus-inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.	Dinoprostone	57-61	progesterone receptor	Rattus norvegicus	111-132
9283049-3	1997	Results suggest that the estrus-inducing action of LHRH, PGE2 and db cAMP occurs through the activation of the progesterone receptor.	Cyclic AMP	69-73	progesterone receptor	Rattus norvegicus	111-132
34904297-10	2022	Finally, antagonism of either AVPV PGR or Src blocked the ability of PGR or Src activation to induce an LH surge in estradiol-primed ovx/adx rats.	Estradiol	116-125	progesterone receptor	Rattus norvegicus	69-72
34850077-8	2021	Finally, we demonstrated that NAC selectively normalized uterine leukemia inhibitory factor, osteopontin/secreted phosphoprotein 1, progesterone receptor, and homeobox A11 mRNA expression and placental estrogen related receptor beta and trophoblast specific protein alpha mRNA expression.	Acetylcysteine	30-33	progesterone receptor	Rattus norvegicus	132-153
34904297-0	2022	Progesterone receptor-Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats.	neuroprogesterone	60-77	progesterone receptor	Rattus norvegicus	0-21
34904297-6	2022	Estradiol treatment increased the number of PGR immunopositive cells and PGR and Src colocalization.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	44-47
34904297-6	2022	Estradiol treatment increased the number of PGR immunopositive cells and PGR and Src colocalization.	Estradiol	0-9	progesterone receptor	Rattus norvegicus	73-76
34904297-7	2022	Furthermore, estradiol treatment increased the number of AVPV cells that had extranuclear PGR and Src in close proximity (< 40 nm).	Estradiol	13-22	progesterone receptor	Rattus norvegicus	90-93
34164810-5	2021	Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG).	Lithium	96-103	progesterone receptor	Rattus norvegicus	21-23
34164810-5	2021	Finally, we assessed PR regulation of epileptic seizures and status epilepticus (SE) induced by lithium-pilocarpine in female rats with the global deletion of PRs (PR knockout; PRKO) using video electroencephalography (-EEG).	Pilocarpine	104-115	progesterone receptor	Rattus norvegicus	21-23