PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28559392-0	2017	Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension.	Salts	92-96	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	62-69
11983491-1	2002	Licorice-derivatives such as glycyrrhizic acid (GA) competitively inhibit 11 beta-hydroxysteroid dehydrogenase(11 beta-HSD) type 2 (11-HSD2) enzymatic activity, and chronic clinical use often results in pseudoaldosteronism.	Glycyrrhizic Acid	29-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	132-139
11983491-1	2002	Licorice-derivatives such as glycyrrhizic acid (GA) competitively inhibit 11 beta-hydroxysteroid dehydrogenase(11 beta-HSD) type 2 (11-HSD2) enzymatic activity, and chronic clinical use often results in pseudoaldosteronism.	Glycyrrhizic Acid	48-50	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	132-139
10232677-6	1999	Consistent with the expression of 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes glucocorticoids to inactive 11-dehydroderivates, carbenoxolone potentiated the corticosterone-stimulated Isc.	Carbenoxolone	145-158	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	34-76
10232677-6	1999	Consistent with the expression of 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes glucocorticoids to inactive 11-dehydroderivates, carbenoxolone potentiated the corticosterone-stimulated Isc.	Corticosterone	175-189	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	34-76
34251271-12	2021	Aldosterone-independent MR activation is probably mediated by glucocorticoids due to low expression of 11beta-HSD2.	Aldosterone	0-11	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	103-114
33813843-0	2021	Decreased 11beta-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice.	Nicotine	96-104	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	10-52
33813843-3	2021	We hypothesized that nicotine-induced blood pressure elevation is in part mediated by change in renal 11beta-HSD2 leading to higher MR (mineralocorticoid receptor) occupancy.	Nicotine	21-29	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	102-113
33813843-4	2021	Here, we show that nicotine exposure markedly decreased the expression and activity of renal 11beta-HSD2 and increased the mean systolic arterial pressure in C57BL/6J mice.	Nicotine	19-27	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	93-104
33813843-5	2021	Reduction of renal 11beta-HSD2 expression by nicotine was correlated with the suppression of C/EBPbeta (CCAAT/enhancer-binding protein-beta) and activation of Akt protein kinase phosphorylation (pThr308Akt/PKB) within the kidney.	Nicotine	45-53	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	19-30
33813843-8	2021	Suppression of Akt/PKB activation by spironolactone was accompanied by upregulation of renal C/EBPbeta and amelioration of nicotine-mediated reduction of 11beta-HSD2.	Spironolactone	37-51	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	154-165
33813843-8	2021	Suppression of Akt/PKB activation by spironolactone was accompanied by upregulation of renal C/EBPbeta and amelioration of nicotine-mediated reduction of 11beta-HSD2.	Nicotine	123-131	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	154-165
33813843-9	2021	Addition of nicotine to mouse renal cortical collecting duct M1 cells downregulated 11beta-HSD2 and stimulated MR expression, and these effects are likely mediated by activation of Akt coupled inhibition of C/EBPbeta.	Nicotine	12-20	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	84-95
33813843-10	2021	These findings suggest that nicotine-mediated suppression of 11beta-HSD2 in the kidney may contribute to the development of nicotine/smoking-induced hypertension through decreasing the intrarenal deactivation of glucocorticoids.	Nicotine	28-36	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	61-72
33813843-10	2021	These findings suggest that nicotine-mediated suppression of 11beta-HSD2 in the kidney may contribute to the development of nicotine/smoking-induced hypertension through decreasing the intrarenal deactivation of glucocorticoids.	Nicotine	124-132	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	61-72
33866550-16	2021	In comparison with untreated animals, BEA decreased GC and 11-betaHSD1 expression while increasing 11-betaHSD2 expression.	16-bromoepiandrosterone	38-41	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	99-110
32395877-3	2020	Data from hepatocytes derived from Hnf1a knock-out mice demonstrated dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which regulates glucocorticoid availability and action in target tissues, together with 11beta-HSD2 and steroid A-ring reductases, 5alpha- and 5beta-reductase.	Steroids	100-107	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	232-243
32765692-1	2020	11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2) is one of the key enzymes in glucocorticoid metabolism, which can inactivate local corticosterone and regulate the level of active glucocorticoid in tissues.	Corticosterone	135-149	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	39-50
32765692-2	2020	The expression of 11beta-HSD2 and its regulatory pathway serve an important role in the apoptosis of steroid induced osteonecrosis of the femoral head (SANFH).	Steroids	101-108	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	18-29
32765692-3	2020	The present study aimed to identify the regulatory effects of cAMP on the expression of Sp1 transcription factor (Sp1) and 11beta-HSD2 in osteocytes at the cellular level.	Cyclic AMP	62-66	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	123-134
32765692-8	2020	The aforementioned results indicated that intracellular cAMP levels significantly regulated the expression of Sp1 and 11beta-HSD2 in mouse osteocytes and osteoblasts.	Cyclic AMP	56-60	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	118-129
31600723-0	2020	Progesterone-regulated Hsd11b2 as a barrier to balance mouse uterine corticosterone.	Progesterone	0-12	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	23-30
31600723-0	2020	Progesterone-regulated Hsd11b2 as a barrier to balance mouse uterine corticosterone.	Corticosterone	69-83	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	23-30
31600723-3	2020	11beta-Hydroxysteroid dehydrogenases type I and II (Hsd11b1/Hsd11b2) are main enzymes for regulating local level of GCs.	Hydroxysteroids	0-21	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	60-67
31600723-7	2020	We found that Hsd11b2 is highly expressed in endometrial stromal cells on days 3 and 4 of pregnancy and mainly upregulated by progesterone (P4).	Progesterone	126-138	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	14-21
31600723-10	2020	The uterine level of Corticosterone (Cort) is regulated by Hsd11b2 during preimplantation.	Corticosterone	21-35	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	59-66
31600723-10	2020	The uterine level of Corticosterone (Cort) is regulated by Hsd11b2 during preimplantation.	Corticosterone	21-25	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	59-66
30990748-9	2019	We generated mice with an Hsd11b2 placental-specific disruption (Hsd11b2PKO) and observed moderately elevated corticosterone levels in offspring, along with increased body weight.	Corticosterone	110-124	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	26-33
30343334-2	2019	Aldosterone boosts the activity of neurons that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a hallmark of aldosterone-sensitive cells.	Aldosterone	122-133	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	56-99
30343334-2	2019	Aldosterone boosts the activity of neurons that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a hallmark of aldosterone-sensitive cells.	Aldosterone	122-133	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	101-105
27733368-2	2017	NCC activity can be stimulated by aldosterone administration, and the mechanism is assumed to depend on the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which inactivates glucocorticoids that would otherwise occupy aldosterone receptors.	Aldosterone	34-45	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	159-170
12925564-3	2003	It has been suggested that 11HSD2 influences vascular function directly by limiting glucocorticoid-mediated inhibition of endothelium-derived nitric oxide.	Nitric Oxide	142-154	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	27-33
12925564-10	2003	Incubation in medium containing l-arginine reversed the endothelial cell dysfunction associated with 11HSD2 inactivation.	Arginine	32-42	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	101-107
10760057-2	2000	In aldosterone target tissues, like the epithelial cells of the distal colon and the principal cells of the collecting ducts in the kidney, the MR is protected from glucocorticoids by the action of the enzyme 11beta-hydroxysteroid-dehydrogenase type 2 (11betaOHSD2), allowing aldosterone to specifically activate the receptor.	Aldosterone	3-14	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	209-264
9099907-7	1997	Using an in-house mouse 11beta-HSD2 cDNA and NAD-dependent activity studies, 11 beta-HSD2 was expressed in epithelial cells of colon, renal collecting ducts, ovary, and adrenal, but was absent in liver, spleen, testis and heart.	NAD	45-48	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	77-89
9099907-12	1997	The sexual-dimorphic expression 11 beta-HSD2 in kidney and colon may reflect male-female differences in sodium homeostasis, and the absent expression of 11 beta-HSD2 in late gestation may facilitate glucocorticoid-dependent maturation of mouse fetal tissues.	Sodium	104-110	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	32-44
35506380-2	2022	Although aldosterone activates MR to increase epithelial sodium channel (ENaC) activity, glucocorticoids also activate MR but are metabolized by 11betaHSD2 (11beta-hydroxysteroid dehydrogenase type 2).	Aldosterone	9-20	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	145-155
35506380-2	2022	Although aldosterone activates MR to increase epithelial sodium channel (ENaC) activity, glucocorticoids also activate MR but are metabolized by 11betaHSD2 (11beta-hydroxysteroid dehydrogenase type 2).	Aldosterone	9-20	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	157-199
35506380-2	2022	Although aldosterone activates MR to increase epithelial sodium channel (ENaC) activity, glucocorticoids also activate MR but are metabolized by 11betaHSD2 (11beta-hydroxysteroid dehydrogenase type 2).	Sodium	57-63	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	145-155
35506380-2	2022	Although aldosterone activates MR to increase epithelial sodium channel (ENaC) activity, glucocorticoids also activate MR but are metabolized by 11betaHSD2 (11beta-hydroxysteroid dehydrogenase type 2).	Sodium	57-63	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	157-199
34057472-5	2021	In this study, we comparative analyzed the expression of genes for progesterone converting enzymes (Cytochrome(CYP)11B1, CYP21A2, Hydroxysteroid(HSD)11B2) and cortisol receptor (NR3C1) in VF and NVF granulosa cells.	Progesterone	67-79	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	130-153
33420760-4	2021	In a second cohort of mice, we measured the expression of 3 genes that code for steroidogenic enzymes that regulate corticosterone levels (Cyp11b1, Hsd11b1, and Hsd11b2) in the HPC, CC, and HYP.	Corticosterone	116-130	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	161-168
33387577-7	2021	Exchange of the C-terminus and substitution of residues Leu170,Ile172 in mouse 11beta-HSD2 by the corresponding residues His170,Glu172 of the human enzyme resulted in a gain of sensitivity to itraconazole and posaconazole, resembling human 11beta-HSD2.	Itraconazole	192-204	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	79-90
33387577-7	2021	Exchange of the C-terminus and substitution of residues Leu170,Ile172 in mouse 11beta-HSD2 by the corresponding residues His170,Glu172 of the human enzyme resulted in a gain of sensitivity to itraconazole and posaconazole, resembling human 11beta-HSD2.	posaconazole	209-221	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	79-90
30302860-6	2019	Finally, our in vivo study elucidated that inhibition of 11betaHSD2 with pharmacological inhibitor, Glycyrrhetinic acid (GA) could significantly diminish tumorigenesis in a well-studied in vivo mouse model of NMSC.	Glycyrrhetinic Acid	100-119	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	57-67
30302860-6	2019	Finally, our in vivo study elucidated that inhibition of 11betaHSD2 with pharmacological inhibitor, Glycyrrhetinic acid (GA) could significantly diminish tumorigenesis in a well-studied in vivo mouse model of NMSC.	Glycyrrhetinic Acid	121-123	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	57-67
30212527-0	2018	Antenatal exposure to betamethasone induces placental 11beta-hydroxysteroid dehydrogenase type 2 expression and the adult metabolic disorders in mice.	Betamethasone	22-35	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	54-96
30212527-4	2018	Exposure of pregnant dams to betamethasone significantly increases the expression of placental 11beta-HSD2 but not 11beta-HSD1, and decreases the weights of fetuses but not placentas.	Betamethasone	29-42	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	95-106
30212527-7	2018	The present study demonstrates that exposure of pregnant dams to betamethasone induces the expression of placental 11beta-HSD2 but not 11beta-HSD1, leads to fetal IUGR and causes adult metabolic disorders, providing evidence for fetal origins of adult diseases and the potential role of placental 11beta-HSD2 in them.	Betamethasone	65-78	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	115-126
30212527-7	2018	The present study demonstrates that exposure of pregnant dams to betamethasone induces the expression of placental 11beta-HSD2 but not 11beta-HSD1, leads to fetal IUGR and causes adult metabolic disorders, providing evidence for fetal origins of adult diseases and the potential role of placental 11beta-HSD2 in them.	Betamethasone	65-78	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	297-308
28698139-1	2017	The aim of the present study was to confirm the role of 11beta-hydroxysteroid dehydrogenases type 2(11beta-HSD-2) in steroid induced osteonecrosis of the femoral head(SANFH).	Steroids	70-77	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	100-112
28698139-3	2017	After overexpressed 11beta-HSD-2 successfully, we induced cell apoptosis by dexamethasone (DXM).	Dexamethasone	76-89	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	20-32
28698139-3	2017	After overexpressed 11beta-HSD-2 successfully, we induced cell apoptosis by dexamethasone (DXM).	Dexamethasone	91-94	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	20-32
28698139-10	2017	In our study, we concluded that 11beta-HSD-2 plays an important role in the development of bone or osteoblast cell apoptosis, and the decreased expression of 11beta-HSD-2 may aggravate steroid induced bone/osteoblast cell apoptosis.	Steroids	185-192	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	158-170
28559392-1	2017	Genome-wide analysis of renal sodium-transporting system has identified specific variations of Mendelian hypertensive disorders, including HSD11B2 gene variants in apparent mineralocorticoid excess.	Sodium	30-36	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	139-146
28320863-8	2017	Both basal and phorbol 12-myristate 13-acetate (PMA)-induced NADPH oxidase activity were increased in RacET and correlated positively with 11beta-HSD2 expression (r = 0.788 and r = 0.843, respectively).	Tetradecanoylphorbol Acetate	15-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	139-150
28320863-8	2017	Both basal and phorbol 12-myristate 13-acetate (PMA)-induced NADPH oxidase activity were increased in RacET and correlated positively with 11beta-HSD2 expression (r = 0.788 and r = 0.843, respectively).	Tetradecanoylphorbol Acetate	48-51	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	139-150
28320863-11	2017	Cardiomyocyte transfection with 11beta-HSD2 siRNA abolished the aldosterone-induced CTGF up-regulation.	Aldosterone	64-75	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	32-43
28320863-12	2017	Aldosterone-stimulated MR nuclear translocation was blocked by the 11beta-HSD2 inhibitor carbenoxolone.	Carbenoxolone	89-102	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	67-78
27918529-0	2017	HSD2 neurons in the hindbrain drive sodium appetite.	Sodium	36-42	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-4
28191869-6	2017	Remarkably, reinstatement of 11beta-HSD2 expression, or AMFR loss, reverses enzalutamide resistance in mouse xenograft tumors.	enzalutamide	76-88	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-40
27918529-2	2017	Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger.	Sodium	213-219	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	88-130
27918529-2	2017	Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger.	Sodium	213-219	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	132-136
27918529-3	2017	These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.	Sodium	65-71	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	6-10
27918529-3	2017	These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.	Sodium	144-150	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	6-10
26978742-4	2016	Here, we tested the effects on alcohol intake of the 11beta-HSD inhibitor carbenoxolone (CBX, 18beta-glycyrrhetinic acid 3beta-O-hemisuccinate), which has been extensively used in the clinic for the treatment of gastritis and peptic ulcer and is active on both 11beta-HSD1 and 11beta-HSD2 isoforms.	Carbenoxolone	74-87	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	277-288
27798095-7	2016	11beta-HSD2, the enzyme that inactivates glucocorticoids to increase MR selectivity for aldosterone, is also increased in dystrophic muscle tissues.	Aldosterone	88-99	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
27185937-9	2016	Pravastatin administration from E6.5, which increases placental vascular endothelial growth factor A and, thus, vascularization, increased placental fetal capillary volume, ameliorated the aberrant umbilical cord velocity, normalized fetal weight, and improved the cardiac function of Hsd11b2(-/-) fetuses.	Pravastatin	0-11	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	285-292
26951843-0	2016	Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.	Salts	52-56	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	24-31
26951843-6	2016	When offered saline to drink, Hsd11b2.BKO mice consumed 3 times more sodium than controls and became hypertensive.	Sodium Chloride	13-19	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	30-37
26951843-6	2016	When offered saline to drink, Hsd11b2.BKO mice consumed 3 times more sodium than controls and became hypertensive.	Sodium	69-75	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	30-37
26951843-10	2016	Salt sensitivity in Hsd11b2.BKO mice was not caused by impaired renal sodium excretion or volume expansion; pressor responses to phenylephrine were enhanced and baroreflexes impaired in these animals.	Salts	0-4	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	20-27
26951843-11	2016	CONCLUSIONS: Reduced 11betaHSD2 activity in the brain does not intrinsically cause hypertension, but it promotes a hunger for salt and a transition from salt resistance to salt sensitivity.	Salts	126-130	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	21-31
26951843-11	2016	CONCLUSIONS: Reduced 11betaHSD2 activity in the brain does not intrinsically cause hypertension, but it promotes a hunger for salt and a transition from salt resistance to salt sensitivity.	Salts	153-157	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	21-31
26951843-11	2016	CONCLUSIONS: Reduced 11betaHSD2 activity in the brain does not intrinsically cause hypertension, but it promotes a hunger for salt and a transition from salt resistance to salt sensitivity.	Salts	153-157	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	21-31
26951843-12	2016	Our data suggest that 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor-dependent pathway.	Salts	60-64	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	22-32
26951843-12	2016	Our data suggest that 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor-dependent pathway.	Sodium	117-123	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	22-32
26978742-6	2016	The CBX diastereomer 18alpha-glycyrrhetinic acid 3beta-O-hemisuccinate (alphaCBX), which we found to be selective for 11beta-HSD2, was also effective in reducing alcohol drinking in mice.	Carbenoxolone	4-7	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	118-129
26978742-6	2016	The CBX diastereomer 18alpha-glycyrrhetinic acid 3beta-O-hemisuccinate (alphaCBX), which we found to be selective for 11beta-HSD2, was also effective in reducing alcohol drinking in mice.	Carbenoxolone	21-70	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	118-129
26978742-6	2016	The CBX diastereomer 18alpha-glycyrrhetinic acid 3beta-O-hemisuccinate (alphaCBX), which we found to be selective for 11beta-HSD2, was also effective in reducing alcohol drinking in mice.	alphacbx	72-80	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	118-129
25434283-10	2015	With lung explants incubated with [(3)H]-corticosterone as substrate, [(3)H]-4-pregnen-21-ol-3,11,20-trione (11-dehydrocorticosterone), the product of 11beta-HSD2, accumulated in higher proportion on GD 15.5 than at later developmental time points.	[(3)h]-4-pregnen-21-ol-3,11,20-trione	70-107	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	151-162
27158392-4	2016	Inhibitor of 11betaHSD2 glycyrrhizic acid (GA) significantly reduced the liver metastasis of colorectal cancers cells seeded in the Appendix serous of the nude mice.	Glycyrrhizic Acid	24-41	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	13-23
27158392-4	2016	Inhibitor of 11betaHSD2 glycyrrhizic acid (GA) significantly reduced the liver metastasis of colorectal cancers cells seeded in the Appendix serous of the nude mice.	Glycyrrhizic Acid	43-45	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	13-23
26855884-5	2015	Compared to males, females were resistant to arsenic induced changes in GR, 11beta-Hsd-1 and 11beta-Hsd-2 protein levels despite observed elevations in Nr3c1 and Hsd11b2 mRNA.	Arsenic	45-52	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	162-169
26741814-6	2016	Reduced expression of 11beta-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	22-33
22777941-11	2012	This study shows that reduced 11beta-hydroxysteroid dehydrogenase type 2 causes salt sensitivity of blood pressure because of impaired renal natriuretic capacity.	Salts	80-84	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	30-72
24490674-11	2014	We also found decreased expression levels of 11beta-hydroxysteroid dehydrogenase type 2, suggesting that corticosterone is apt to bind to MR.	Corticosterone	105-119	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	45-87
23986571-7	2013	In contrast, both routes of dex treatment from D14 to D19 increased placental Hsd11b2 expression and labyrinthine maternal vessel volume.	Dexamethasone	28-31	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	78-85
25459689-10	2015	This suggests that arsenic exposure may alter GR expression levels as a consequence of a prolonged developmental imbalance between 11beta-HSD1 and 11beta-HSD2 protein expression despite decreased 11HSDB2 mRNA.	Arsenic	19-26	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	147-158
24469458-4	2014	11beta-HSD2 converts cortisol to receptor-inactive metabolites allowing aldosterone occupancy of MR. 11beta-HSD2 was up-regulated by arrhythmic pacing in cultured cardiomyocytes and in a mouse model of spontaneous AF (RacET).	Aldosterone	72-83	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
24424066-9	2014	Reduced SCGRKO testicular expression of Hsd11b2, encoding an enzyme for corticosterone inactivation, supports a dynamic coupling between Hsd11b and androgen production.	Corticosterone	72-86	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	40-47
24096962-3	2013	The cortisol/cortisone (F/E) ratio in humans and the corticosterone/11-dehydrocorticosterone (B/A) ratio in mice are markers of the activity of HSD11B2.	Hydrocortisone	4-12	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	144-151
24096962-3	2013	The cortisol/cortisone (F/E) ratio in humans and the corticosterone/11-dehydrocorticosterone (B/A) ratio in mice are markers of the activity of HSD11B2.	Cortisone	13-22	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	144-151
24096962-3	2013	The cortisol/cortisone (F/E) ratio in humans and the corticosterone/11-dehydrocorticosterone (B/A) ratio in mice are markers of the activity of HSD11B2.	Corticosterone	53-67	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	144-151
24096962-3	2013	The cortisol/cortisone (F/E) ratio in humans and the corticosterone/11-dehydrocorticosterone (B/A) ratio in mice are markers of the activity of HSD11B2.	11-dehydrocorticosterone	68-92	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	144-151
23880315-4	2013	The first is placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is known to protect the fetus from exposure to high cortisol levels and subsequently FGR, and the second the cadmium binding/sequestering proteins metallotheionein (MT)-I and -II.	Hydrocortisone	146-154	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	74-85
23880315-4	2013	The first is placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is known to protect the fetus from exposure to high cortisol levels and subsequently FGR, and the second the cadmium binding/sequestering proteins metallotheionein (MT)-I and -II.	Cadmium	203-210	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	74-85
21282561-0	2011	Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure.	Salts	42-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-7
22777941-0	2012	Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice.	Salts	61-65	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	81-88
22777941-7	2012	In Hsd11b2(+/-) mice, the natriuretic response to increased dietary sodium content was blunted, and epithelial sodium channel activity persisted.	Sodium	68-74	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	3-10
22777941-8	2012	High-sodium diet also reduced renal blood flow and increased blood pressure in Hsd11b2(+/-) mice.	Sodium	5-11	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	79-86
22777941-9	2012	Aldosterone was modulated by dietary sodium in both genotypes, and salt sensitivity in Hsd11b2(+/-) mice was associated with increased plasma corticosterone levels.	Salts	67-71	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	87-94
22777941-9	2012	Aldosterone was modulated by dietary sodium in both genotypes, and salt sensitivity in Hsd11b2(+/-) mice was associated with increased plasma corticosterone levels.	Corticosterone	142-156	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	87-94
22777941-10	2012	Chronic administration of an epithelial sodium channel blocker or a glucocorticoid receptor antagonist prevented salt sensitivity in Hsd11b2(+/-) mice, whereas mineralocorticoid receptor blockade with spironolactone did not.	Salts	113-117	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	133-140
22042385-6	2012	Indeed, global removal of 11beta-HSD2, an enzyme that inactivates glucocorticoids, increases anxiety- and depressive-like behaviour in mice; however, in this case the phenotype is not accompanied by overt perturbation in the HPA axis but, intriguingly, alterations in serotonergic and catecholamine pathways are maintained in this programming model.	Catecholamines	285-298	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	26-37
21880714-0	2011	Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells.	triterpenoids	36-49	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	102-112
21880714-2	2011	Ligand fitting of five different triterpenoids to 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) was analyzed with a molecular modeling method, and glycyrrhetinic acid (GA) was the best-fitted triterpenoid to the ligand binding site in 11betaHSD2.	triterpenoids	33-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	94-104
21880714-2	2011	Ligand fitting of five different triterpenoids to 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) was analyzed with a molecular modeling method, and glycyrrhetinic acid (GA) was the best-fitted triterpenoid to the ligand binding site in 11betaHSD2.	Glycyrrhetinic Acid	157-176	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	94-104
21880714-2	2011	Ligand fitting of five different triterpenoids to 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) was analyzed with a molecular modeling method, and glycyrrhetinic acid (GA) was the best-fitted triterpenoid to the ligand binding site in 11betaHSD2.	Glycyrrhetinic Acid	157-176	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	245-255
21880714-2	2011	Ligand fitting of five different triterpenoids to 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) was analyzed with a molecular modeling method, and glycyrrhetinic acid (GA) was the best-fitted triterpenoid to the ligand binding site in 11betaHSD2.	triterpenoid TP-222	33-45	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	94-104
21880714-6	2011	Furthermore, GA exhibited a strong inhibitory effect on 11betaHSD2 activity in the tumor cells.	Glycyrrhetinic Acid	13-15	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	56-66
21880714-8	2011	To the best of our knowledge, this is the first report on in silico prediction of the toxic effects of triterpenoids on tumor cells by 11betaHSD2 inhibition.	triterpenoids	103-116	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	135-145
21282561-8	2011	After 21 days of high-sodium feeding, Hsd11b2(+/-) mice had an increased heart weight.	Sodium	22-28	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	38-45
22622456-2	2012	Null mutations in the encoding gene, HSD11B2, cause apparent mineralocorticoid excess, in which hypertension is thought to reflect volume expansion secondary to sodium retention.	Sodium	161-167	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	37-44
21667072-1	2012	Molecular docking and structural analysis of the cofactor-protein interaction between NAD(+) and human (h) or mouse (m) 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) were performed with the molecular operating environment (MOE).	NAD	86-92	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	120-162
21667072-1	2012	Molecular docking and structural analysis of the cofactor-protein interaction between NAD(+) and human (h) or mouse (m) 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) were performed with the molecular operating environment (MOE).	NAD	86-92	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	164-174
21667072-2	2012	11betaHSD1 (PDB code: 3HFG) was selected as a template for the 3D structure modeling of 11betaHSD2.	3hfg	22-26	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	88-98
22004954-8	2011	The mRNA expressions of placental 11beta-HSD-2 were dose-dependently reduced in dexamethasone groups, particularly, the mRNA decreased to 22.2% in 8.0mg/kg dexamethasone group, as compared with the control (P=0.15).	Dexamethasone	80-93	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	34-46
22004954-8	2011	The mRNA expressions of placental 11beta-HSD-2 were dose-dependently reduced in dexamethasone groups, particularly, the mRNA decreased to 22.2% in 8.0mg/kg dexamethasone group, as compared with the control (P=0.15).	Dexamethasone	156-169	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	34-46
21282561-11	2011	In Hsd11b2(+/-) mice, high-sodium feeding caused suppression of aldosterone and a moderate but sustained increase in corticosterone.	Sodium	27-33	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	3-10
21282561-4	2011	Polymorphisms in HSD11B2 are associated with salt sensitivity of blood pressure in normotensives.	Salts	45-49	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	17-24
21282561-6	2011	A high-sodium diet caused a rapid and sustained increase in blood pressure in Hsd11b2(+/-) mice but not in wild-type littermates.	Sodium	7-13	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	78-85
19720048-4	2009	Interestingly, MEHP inhibited Hsd11b2 mRNA level and 11beta-HSD2 enzyme activity in LbetaT2 cells at as low as 10(-7)M. Corticosterone (CORT) at a concentration of 10(-6)M significantly inhibited LbetaT2 cell proliferation after 2-day culture, and 10(-6)M RU486, an antagonist of glucocorticoid receptor (GR), reversed this inhibition.	mono-(2-ethylhexyl)phthalate	15-19	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	30-37
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	137-151	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	153-157	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	218-222	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	11-dehydrocorticosterone	227-251	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	11-dehydrocorticosterone	253-258	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
19696010-2	2010	The enzymes hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1) and HSD11B2 catalyze the interconversion of inactive cortisone and active cortisol, which is a biologically active glucorticoid and ligand for the receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1).	Cortisone	116-125	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	67-74
21106873-11	2011	Similarly, aldosterone increased vascular cell adhesion molecule 1 expression in mouse aortic endothelial cells, an effect mimicked by corticosterone only in the presence of an 11beta-HSD2 inhibitor.	Aldosterone	11-22	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	177-188
21106873-11	2011	Similarly, aldosterone increased vascular cell adhesion molecule 1 expression in mouse aortic endothelial cells, an effect mimicked by corticosterone only in the presence of an 11beta-HSD2 inhibitor.	Corticosterone	135-149	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	177-188
19720048-4	2009	Interestingly, MEHP inhibited Hsd11b2 mRNA level and 11beta-HSD2 enzyme activity in LbetaT2 cells at as low as 10(-7)M. Corticosterone (CORT) at a concentration of 10(-6)M significantly inhibited LbetaT2 cell proliferation after 2-day culture, and 10(-6)M RU486, an antagonist of glucocorticoid receptor (GR), reversed this inhibition.	mono-(2-ethylhexyl)phthalate	15-19	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	53-64
19720048-7	2009	MEHP may participate in the glucocorticoid metabolism in LbetaT2 cells through inhibition of 11beta-HSD2 enzyme activity.	mono-(2-ethylhexyl)phthalate	0-4	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	93-104
18162527-6	2008	Because expression of 11beta-hydroxysteroid dehydrogenase type 2, was much higher in the mouse ovary than in the testis, conversion of testosterone into 11-KT may occur more efficiently in the ovary.	Testosterone	135-147	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	22-64
19409113-8	2009	Four reporter gene plasmids containing various lengths of Hsd11b2 promoter region were constructed and transfected into mouse Leydig tumor cells to investigate the effect of LH on Hsd11b2 transcription.	Luteinizing Hormone	174-176	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	180-187
18845627-9	2009	Furthermore, at E18, placental glucose transport to 11beta-HSD2(-/-) offspring was markedly reduced, correlating with lower fetal weight and a decrease in glucose transporter 3 expression.	Glucose	31-38	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	52-63
18032795-1	2008	The syndrome of apparent mineralocorticoid excess arises from nonfunctional mutations in 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), an enzyme that inactivates cortisol and confers aldosterone specificity on the mineralocorticoid receptor.	Aldosterone	194-205	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	133-143
18032795-6	2008	By 80 days of age, however, channel activity was abolished and 11betaHSD2(-/-) mice lost salt.	Salts	89-93	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	63-73
18032795-8	2008	Instead, urinary catecholamine levels in 11betaHSD2(-/-) mice were double those in wild-type mice, and alpha1-adrenergic receptor blockade rescued the hypertensive phenotype, suggesting that vasoconstriction contributes to the sustained hypertension in this model.	Catecholamines	17-30	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	41-51
16413106-8	2006	11Beta-HSD2 acts as a dehydrogenase, inactivating corticosterone or cortisol through conversion to 11-dehydrocorticosterone and cortisone.	Corticosterone	50-64	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	NAD	4-8	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	11beta	96-102	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	Hydrocortisone	116-124	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	Corticosterone	129-143	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	adrenosterone	153-159	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
18032795-1	2008	The syndrome of apparent mineralocorticoid excess arises from nonfunctional mutations in 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), an enzyme that inactivates cortisol and confers aldosterone specificity on the mineralocorticoid receptor.	Hydrocortisone	173-181	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	133-143
16413106-8	2006	11Beta-HSD2 acts as a dehydrogenase, inactivating corticosterone or cortisol through conversion to 11-dehydrocorticosterone and cortisone.	Hydrocortisone	68-76	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
16413106-8	2006	11Beta-HSD2 acts as a dehydrogenase, inactivating corticosterone or cortisol through conversion to 11-dehydrocorticosterone and cortisone.	11-dehydrocorticosterone	99-123	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
16413106-8	2006	11Beta-HSD2 acts as a dehydrogenase, inactivating corticosterone or cortisol through conversion to 11-dehydrocorticosterone and cortisone.	Cortisone	128-137	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
16254034-3	2006	We found that 11beta-HSD2, as well as -HSD1, was expressed in the cells and that its inhibition by carbenoxolone significantly improved the negative feedback effect of glucocorticoid.	Carbenoxolone	99-112	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	14-25
16254034-5	2006	These effects are most likely attributable to inhibition of 11beta-HSD2 because only cortisol, a substrate of 11beta-HSD2, was present in these experimental conditions.	Hydrocortisone	85-93	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	60-71
16254034-5	2006	These effects are most likely attributable to inhibition of 11beta-HSD2 because only cortisol, a substrate of 11beta-HSD2, was present in these experimental conditions.	Hydrocortisone	85-93	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	110-121
16289840-6	2006	When exogenous corticosterone was administered to the pups between postnatal days 4 and 13, 11beta-hydroxysteroid dehydrogenase type 2(-/-) mice were more sensitive, showing further inhibition of cerebellar growth while the wildtype mice were not affected.	Corticosterone	15-29	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	92-134
16289840-7	2006	Upon withdrawal of exogenous steroid, there was a rebound growth spurt so that at day 21 postnatally, the cerebellar size in 11beta-hydroxysteroid dehydrogenase type 2-/- mice was similar to untreated mice of the same genotype.	Steroids	29-36	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	125-167
15743993-2	2005	Mineralocorticoid specificity is ensured by 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes cortisol or corticosterone into inactive metabolites that are unable to bind MR and/or GR.	Hydrocortisone	106-114	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	44-86
15743993-2	2005	Mineralocorticoid specificity is ensured by 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes cortisol or corticosterone into inactive metabolites that are unable to bind MR and/or GR.	Corticosterone	118-132	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	44-86
15743993-6	2005	At 3 h, the corticosterone dose-response curve was shifted to the right compared with that of aldosterone by more than two log concentrations, an effect that was fully reverted in the presence of the 11beta-hydroxysteroid dehydrogenase type 2 inhibitor carbenoxolone.	Corticosterone	12-26	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	200-242
15743993-6	2005	At 3 h, the corticosterone dose-response curve was shifted to the right compared with that of aldosterone by more than two log concentrations, an effect that was fully reverted in the presence of the 11beta-hydroxysteroid dehydrogenase type 2 inhibitor carbenoxolone.	Carbenoxolone	253-266	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	200-242
16289840-1	2006	11beta-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-42
16289840-1	2006	11beta-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives.	Hydrocortisone	139-147	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-42
15199296-8	2004	Renal sodium retention in liver cirrhosis, nephrotic syndrome and hypoxia have been linked to 11beta-HSD2 reduced activity.	Sodium	6-12	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	94-105