PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32688367-5	2020	Similar to previous results with R,S-ketamine, administration of L-655,709 increased levels of GluA1 in the mPFC and, blockade of such receptors by direct administration of NBQX into the mPFC blocked the sustained AD-like effect of L-655,708.	L-655	65-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	95-100
32343420-3	2020	We observed that following NMDA, but not DHPG preconditioning, the expression of GluA1 was significantly reduced and this reduction appeared to be associated with the internalization of AMPA receptors.	N-Methylaspartate	27-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
32343420-8	2020	In conclusion, preconditioning with NMDA or DHPG promotes differential neuroprotective mechanisms: NMDA by internalization of GluA1-AMPA receptors, DHPG by producing the endocannabinoid 2-AG.	N-Methylaspartate	36-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
32343420-8	2020	In conclusion, preconditioning with NMDA or DHPG promotes differential neuroprotective mechanisms: NMDA by internalization of GluA1-AMPA receptors, DHPG by producing the endocannabinoid 2-AG.	3,5-dihydroxyphenylglycine	44-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
32343420-8	2020	In conclusion, preconditioning with NMDA or DHPG promotes differential neuroprotective mechanisms: NMDA by internalization of GluA1-AMPA receptors, DHPG by producing the endocannabinoid 2-AG.	N-Methylaspartate	99-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
32688367-7	2020	These experiments indicate that the sustained AD-like effects of L-655,708 require protein synthesis and plasticity of GluA1 glutamate receptors in the mPFC.	Leucine	65-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
32664002-10	2020	Moreover, long-term potentiation was decreased in both the excitatory postsynaptic potential and the population spike in RA-treated rats, presumably a consequence of the reduced glur1 transcript level.	Tretinoin	121-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	178-183
33184769-4	2022	We find that both cortical and hippocampal tissue exhibit changes in glutamate receptor subunit expression, including GluA1 and GluN2B, suggesting that SDs in healthy brain tissue may have a role in plasticity.	sds	152-155	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
32594591-3	2020	Our recent data reveal heightened expression of AMPA receptor (AMPAR) GluA1 subunit in rat ventral tegmental area (VTA), which occurs concurrently with social stress-induced amphetamine (AMPH) cross-sensitization.	Amphetamine	174-185	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
32781725-5	2020	In the present study, we found that AMPAR antagonists (perampanel and GYKI 52466) decreased glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) surface expression in the epileptic rat hippocampus.	perampanel	55-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
32781725-5	2020	In the present study, we found that AMPAR antagonists (perampanel and GYKI 52466) decreased glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) surface expression in the epileptic rat hippocampus.	GYKI 52466	70-80	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
32781725-5	2020	In the present study, we found that AMPAR antagonists (perampanel and GYKI 52466) decreased glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) surface expression in the epileptic rat hippocampus.	Glutamic Acid	92-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
32386416-4	2020	The intrathecal injection of Ro25-6981 (a specific antagonist of GluN2B) or Tat-NR2B9c (a mimetic peptide disrupting the interaction between PSD-95 and GluN2B) induced an antihyperalgesic effect and blocked the increased expression of Tyr1472-GluN2B, CaMKII, GluR1, Thr286-CaMKII, and Ser831-GluR1 in the spinal cords; the increase in spinal cord PSD-95 was not affected.	Ro 25-6981	29-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	259-264
32386416-4	2020	The intrathecal injection of Ro25-6981 (a specific antagonist of GluN2B) or Tat-NR2B9c (a mimetic peptide disrupting the interaction between PSD-95 and GluN2B) induced an antihyperalgesic effect and blocked the increased expression of Tyr1472-GluN2B, CaMKII, GluR1, Thr286-CaMKII, and Ser831-GluR1 in the spinal cords; the increase in spinal cord PSD-95 was not affected.	Ro 25-6981	29-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	292-297
32594591-8	2020	Furthermore, wildtype overexpression of GluA1 in VTA DA neurons had the opposite effect; locomotor-activating effects of AMPH were significantly augmented, even in the absence of stress.	Dopamine	53-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	40-45
32594591-8	2020	Furthermore, wildtype overexpression of GluA1 in VTA DA neurons had the opposite effect; locomotor-activating effects of AMPH were significantly augmented, even in the absence of stress.	Amphetamine	121-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	40-45
32563935-6	2020	Our results showed that CUMS-induced depression-like behaviors were accompanied by a decrease in spine density in pyramidal neurons of both the hippocampal CA3 area and the mPFC, and an increase in spine density in both the neurons of BLA and the medium spiny neurons (MSNs) of the NAc, as well as a decrease in the levels of the AMPA receptor subunit GluA1 and Kalirin-7 in the hippocampus compared with the control group.	cums	24-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	352-357
32563935-8	2020	of Dhmc to the CUMS-exposed rats ameliorated CUMS-induced depression-like behaviors and reversed CUMS-mediated alterations in spine density and the levels of both GluA1 and Kalirin-7.	7,8-dihydroxy-4-methylcoumarin	3-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	163-168
32828906-10	2020	Moreover, PCC-0105002 altered signaling downstream of NMDAR and thus functionally and structurally attenuating synaptic plasticity through respective regulation of the NR2B/GluR1/CaMKIIalpha and Rac1/RhoA pathways.	pcc-0105002	10-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-178
32848709-7	2020	Furthermore, the abnormal activation of the D1/PKA/DARPP-32 cascade is paralleled by increased phosphorylation of the GluA1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor at the PKA Ser845 site.	alpha-amino-3-hydroxy-5-methyl-4-	139-172	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
31997814-5	2020	Additionally, we assessed the colocalization of astrocyte plasma membrane labeling with immunoreactivity for AMPA-(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) glutamate receptor 1, an AMPA receptor subunit and established neuronal marker of excitatory synapses, as a metric of astrocyte-synapse proximity.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	115-171	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-193
32594591-3	2020	Our recent data reveal heightened expression of AMPA receptor (AMPAR) GluA1 subunit in rat ventral tegmental area (VTA), which occurs concurrently with social stress-induced amphetamine (AMPH) cross-sensitization.	Amphetamine	187-191	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
32594591-5	2020	The present study evaluated the effects of intermittent social defeat stress on GluA1 expression in VTA dopamine (DA) neurons, then utilized Cre-dependent virus-mediated gene transfer to determine the functional role of homomeric GluA1-AMPARs in these neurons.	Dopamine	104-112	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
32594591-6	2020	Social defeat stress exposure induced GluA1 expression in VTA DA neurons, as demonstrated by a greater density of GluA1/ tyrosine hydroxylase (TH) double-labeling in VTA neurons in stressed rats.	Tyrosine	121-129	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
31821553-9	2020	Furthermore, nicotine exposure promoted autophosphorylation of Ca2+ /calmodulin-dependent kinase II (CaMKII) and serine 831 phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit GluA1.	Nicotine	13-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	214-219
33344690-9	2020	However, fasudil decreased synaptic GluA1 Ser831 phosphorylation in stressed animals.	fasudil	9-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	36-41
32353458-6	2020	Treatment with iTBS significantly improved the spatial cognitive function of RHRSPs, increased the expression of NR2B, p-CaMKIIalpha and GluR1 in the hippocampus, and decreased the proliferation of astrocytes and microglia.	itbs	15-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	137-142
32353458-7	2020	Our results showed that iTBS treatment had a beneficial effect on the cognitive impairments induced by cerebral small vessel disease, potentially through the activation of the NR2B-CaMKII pathway, an increase in GluR1 expression and the suppression of astrocyte and microglial activation.	itbs	24-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	212-217
32147481-0	2020	Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.	evodiamine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	48-53
32147481-0	2020	Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.	Nitroglycerin	63-76	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	48-53
32147481-12	2020	Furthermore, EVO suppressed total protein expression of the AMPA receptor GluA1 and its phosphorylation at Ser831 and Ser845.	evodiamine	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
32147481-13	2020	CONCLUSIONS: This study showed that EVO inhibits the migraine-like pain response and that this beneficial effect might be attributed to the regulation of nNOS and suppression of the AMPA receptor GluA1.	evodiamine	36-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	196-201
31821553-9	2020	Furthermore, nicotine exposure promoted autophosphorylation of Ca2+ /calmodulin-dependent kinase II (CaMKII) and serine 831 phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit GluA1.	Nicotine	13-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	229-234
31994358-11	2020	CONCLUSION: These data demonstrate that adenosine A1 receptors maintain an inhibitory tone on GluA1 S845 phosphorylation under normal conditions.	Adenosine	40-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
32130432-13	2020	RESULTS: Ifenprodil rapidly ameliorated depressive-like behaviors in the FST and SPT, activated mTOR signaling, dephosphorylated eukaryotic elongation factor 2, enhanced BDNF expression, and promoted the synthesis of the synaptic protein GluA1 synthesis after acute administration.	ifenprodil	9-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	238-243
32265648-8	2020	Pharmacologically, microinfusion of the glutamate receptor 1 (GluR1) antagonist NASPM into vlPAG mimicked the depression-like behaviors.	vlpag	91-96	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	40-60
32265648-8	2020	Pharmacologically, microinfusion of the glutamate receptor 1 (GluR1) antagonist NASPM into vlPAG mimicked the depression-like behaviors.	vlpag	91-96	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
32390837-8	2020	Intriguingly, the berberine treatment with or without extinction training altered expression of plasticity-related proteins such as brain-derived neurotrophic factor (BDNF), AMPA receptors (GluA1 and GluA2) in the nucleus accumbens (NAc).	Berberine	18-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	190-195
31994358-0	2020	Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	16-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
31994358-0	2020	Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain.	Adenosine	64-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
32076842-0	2020	Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.	desloratadine	0-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
31994358-6	2020	RESULTS: A systemic injection of the A1 antagonist DPCPX induced an increase in phosphorylation of AMPA receptor GluA1 subunits at a PKA-dependent site, serine 845 (S845), in the two subdivisions of the striatum, the caudate putamen, and nucleus accumbens.	1,3-dipropyl-8-cyclopentylxanthine	51-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	113-118
31994358-6	2020	RESULTS: A systemic injection of the A1 antagonist DPCPX induced an increase in phosphorylation of AMPA receptor GluA1 subunits at a PKA-dependent site, serine 845 (S845), in the two subdivisions of the striatum, the caudate putamen, and nucleus accumbens.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	99-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	113-118
31994358-6	2020	RESULTS: A systemic injection of the A1 antagonist DPCPX induced an increase in phosphorylation of AMPA receptor GluA1 subunits at a PKA-dependent site, serine 845 (S845), in the two subdivisions of the striatum, the caudate putamen, and nucleus accumbens.	cholecystokinin C-terminal flanking peptide	153-159	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	113-118
31376158-10	2020	Thus, NYX-2925 concentrations that increase synaptic GluN2B facilitated the chemical long-term potentiation induced insertion of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunit levels.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	138-194	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	204-209
32076842-0	2020	Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	60-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
32076842-9	2020	Desloratadine ameliorated olfactory dysfunction in AR rats and decreased GluR1 expression in AR rats.	desloratadine	0-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
32076842-11	2020	The expression of AMPA receptor subunit GluR1 in olfactory bulb was associated with olfactory disorder.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	18-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	40-45
31706797-6	2020	At the molecular level, ketamine i) decreased GluN2B, GluA1 and mGluR5 receptors in hippocampus, ii) decreased GluA1 and mGluR5 but increased GluN2B in nucleus accumbens and iii) increased GluN2B and mGluR5 in amygdala.	Ketamine	24-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
31706797-6	2020	At the molecular level, ketamine i) decreased GluN2B, GluA1 and mGluR5 receptors in hippocampus, ii) decreased GluA1 and mGluR5 but increased GluN2B in nucleus accumbens and iii) increased GluN2B and mGluR5 in amygdala.	Ketamine	24-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
31705923-0	2020	Spinal SNAP-25 regulates membrane trafficking of GluA1-containing AMPA receptors in spinal injury-induced neuropathic pain in rats.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	66-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
31863796-5	2020	In contrast, pain decreased the GluA1/GluA2 ratio in the CeA of rats with MSA.	msa	74-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
31863796-6	2020	Microinjection of NASPM, a selective inhibitor of homomeric GluA1-AMPARs, into CeA inhibited morphine intake.	Morphine	93-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
31863796-7	2020	Furthermore, viral overexpression of GluA1 protein in CeA maintained morphine intake at a higher level than controls and reversed the pain-induced reduction in morphine intake.	Morphine	69-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
31863796-7	2020	Furthermore, viral overexpression of GluA1 protein in CeA maintained morphine intake at a higher level than controls and reversed the pain-induced reduction in morphine intake.	Morphine	160-168	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
31705923-12	2020	GluA1-containing AMPA receptor inhibition relieved mechanical allodynia and thermal hyperalgesia after SNL.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	17-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
31705923-15	2020	However, the mechanism of GluA1-containing AMPA receptor membrane trafficking mediated by SNAP-25 phosphorylation in neuropathic pain deserves further exploration.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	43-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	26-31
31757887-1	2019	It is well established that Rab11-dependent recycling endosomes drive the activity-dependent delivery of AMPA receptors (AMPARs) into synapses during long-term potentiation (LTP).	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	105-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-127
32013842-9	2020	Recent studies suggest a mechanistic model in which concurrent stimulation of D1 and GluA2-lacking AMPA receptors enables increased stimulus-induced trafficking of GluA1/GluA2 AMPARs into the postsynaptic density, thereby increasing the incentive effects of food, drugs, and associated cues.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	99-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	164-169
31398381-7	2020	Using an integrative approach combing electrophysiological and cellular mechanisms, the results showed that the impaired eCB-LTD, abnormal mGluR-mediated LTD (mGluR-LTD) and decreased removal of AMPAR subunits GluA1 and GluA2 were reversed by URB597 in the prefrontal cortex (PFC) of VPA-exposed offspring.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	243-249	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	195-200
31398381-7	2020	Using an integrative approach combing electrophysiological and cellular mechanisms, the results showed that the impaired eCB-LTD, abnormal mGluR-mediated LTD (mGluR-LTD) and decreased removal of AMPAR subunits GluA1 and GluA2 were reversed by URB597 in the prefrontal cortex (PFC) of VPA-exposed offspring.	Valproic Acid	284-287	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	195-200
31398381-8	2020	Taken together, these results provide the first evidence that rescue of the ASD-like phenotype by URB597 is mediated by enhancing the mechanism of removal of AMPAR subunits GluA1/2 underlying AEA signaling in the PFC in a VPA-induced model of ASD.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	98-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	158-163
31398381-8	2020	Taken together, these results provide the first evidence that rescue of the ASD-like phenotype by URB597 is mediated by enhancing the mechanism of removal of AMPAR subunits GluA1/2 underlying AEA signaling in the PFC in a VPA-induced model of ASD.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	98-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-178
31394143-10	2019	GluR1 AMPAr subunit levels were higher in the purified and sucrose groups tested at 24 hours compared to the non-tested and control values.	Sucrose	59-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
31394143-10	2019	GluR1 AMPAr subunit levels were higher in the purified and sucrose groups tested at 24 hours compared to the non-tested and control values.	Sucrose	59-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	6-11
31394143-11	2019	GluR1 levels subsequently declined at the 7- and 14-day abstinence periods in the purified and sucrose tested and non-tested groups compared to control values.	Sucrose	95-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
30222904-4	2019	The non-specific group I orthosteric agonist dihydroxyphenylglycine (10 min) decreased cell surface GluA1 but not GluA2, indicating CP-AMPAR internalization.	3,4-dihydroxyphenylglycol	45-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
31335998-6	2019	Striatal levels of GLUR1 were measured as a l-dopa-induced postsynaptic change that is under tumor necrosis factor-alpha control.	Levodopa	44-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
31335998-9	2019	l-Dopa-induced angiogenesis was inhibited in both basal ganglia nuclei, and l-dopa-induced GLUR1 overexpression in the dorsolateral striatum was restored to normal levels.	Levodopa	76-82	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
31251995-2	2019	Here we found that lesions of the substantia nigra pars compacta (SNc) in rats induced depressive-like behaviors, and intra-LHb injection of CP-AMPAR antagonist Naspm produced antidepressant-like effects in SNc sham-lesioned and SNc-lesioned rats, however, the doses inducing these effects in SNc-lesioned rats were lower than that of SNc sham-lesioned rats.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	124-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
31251995-6	2019	Our findings indicate that blockade of LHb CP-AMPARs produces antidepressant-like effects, which attribute to decreased firing activity of LHb neurons and increased levels of dopamine and serotonin in the mPFC, and provide further evidence that LHb CP-AMPARs regulate the firing activity of pVTA dopaminergic neurons and MRN serotonergic neurons indirectly via the RMTg.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	39-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-52
31251995-6	2019	Our findings indicate that blockade of LHb CP-AMPARs produces antidepressant-like effects, which attribute to decreased firing activity of LHb neurons and increased levels of dopamine and serotonin in the mPFC, and provide further evidence that LHb CP-AMPARs regulate the firing activity of pVTA dopaminergic neurons and MRN serotonergic neurons indirectly via the RMTg.	Dopamine	175-183	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-52
31251995-6	2019	Our findings indicate that blockade of LHb CP-AMPARs produces antidepressant-like effects, which attribute to decreased firing activity of LHb neurons and increased levels of dopamine and serotonin in the mPFC, and provide further evidence that LHb CP-AMPARs regulate the firing activity of pVTA dopaminergic neurons and MRN serotonergic neurons indirectly via the RMTg.	Serotonin	188-197	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-52
31251995-6	2019	Our findings indicate that blockade of LHb CP-AMPARs produces antidepressant-like effects, which attribute to decreased firing activity of LHb neurons and increased levels of dopamine and serotonin in the mPFC, and provide further evidence that LHb CP-AMPARs regulate the firing activity of pVTA dopaminergic neurons and MRN serotonergic neurons indirectly via the RMTg.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	139-142	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-52
31251995-6	2019	Our findings indicate that blockade of LHb CP-AMPARs produces antidepressant-like effects, which attribute to decreased firing activity of LHb neurons and increased levels of dopamine and serotonin in the mPFC, and provide further evidence that LHb CP-AMPARs regulate the firing activity of pVTA dopaminergic neurons and MRN serotonergic neurons indirectly via the RMTg.	rmtg	365-369	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-52
31619586-7	2019	IT doses of anti-GluR1 and anti-Gabra1 ASOs markedly reduced the mRNA and protein levels of their respective neurotransmitter receptor protein targets by 2 weeks and anti-Gabra1 ASOs also reduced binding of the GABAA receptor PET ligand 18F-flumazenil in the brain over 4 weeks.	Flumazenil F-18	237-251	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	17-22
31430547-0	2019	Chemokine CCL7 regulates spinal phosphorylation of GluA1-containing AMPA receptor via interleukin-18 in remifentanil-induced hyperalgesia in rats.	Remifentanil	104-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
31430547-8	2019	RESULTS: We reported that acute exposure to remifentanil caused and maintained behavioral RIH with up-regulation of expression in CCL7/CCR2 and IL-18/IL-18R and the phosphorylation of GluA1 in the dorsal horn.	Remifentanil	44-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
31430547-12	2019	CONCLUSION: Our current findings demonstrate that spinal CCL7/CCR2 modulation of GluA1-containing AMPA receptor activation via IL-18 and IL-18R over-expression is an important pathogenesis of remifentanil-induced hyperalgesia in rats.	Remifentanil	192-204	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
30956255-6	2019	Our data showed that xylazine influenced the level of adenosine triphosphate (ATP) ase and cyclic adenosine monophosphate (cAMP), and regulated the expression of GluR1, ERK, PKA, cAMP-response element binding protein (CREB), and brain derived neurotrophic factor (BDNF) in the nervous system.	Xylazine	21-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	162-167
30222904-7	2019	Thus, LY367385 (24 hr) increased surface GluA1 without affecting GluA2, whereas MTEP (24 hr) had no effect.	alpha-methyl-4-carboxyphenylglycine	6-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
30222904-9	2019	Consistent with this, the LY367385-induced increase in surface GluA1 was blocked by anisomycin (translation inhibitor) or 4-(diethylamino)-benzaldehyde (RA synthesis inhibitor).	alpha-methyl-4-carboxyphenylglycine	26-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
30222904-9	2019	Consistent with this, the LY367385-induced increase in surface GluA1 was blocked by anisomycin (translation inhibitor) or 4-(diethylamino)-benzaldehyde (RA synthesis inhibitor).	Anisomycin	84-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
30222904-9	2019	Consistent with this, the LY367385-induced increase in surface GluA1 was blocked by anisomycin (translation inhibitor) or 4-(diethylamino)-benzaldehyde (RA synthesis inhibitor).	4-(diethylamino)benzaldehyde	122-151	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
30222904-9	2019	Consistent with this, the LY367385-induced increase in surface GluA1 was blocked by anisomycin (translation inhibitor) or 4-(diethylamino)-benzaldehyde (RA synthesis inhibitor).	Tretinoin	153-155	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
31209728-6	2019	Results showed that membrane expression of GluA1 and GluA2 in the vmPFC was decreased following the recent retrieval, while the membrane expression of GluA1 and GluA2 in the vmPFC was increased following the remote retrieval of morphine-associated memory.	Morphine	228-236	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
31209728-6	2019	Results showed that membrane expression of GluA1 and GluA2 in the vmPFC was decreased following the recent retrieval, while the membrane expression of GluA1 and GluA2 in the vmPFC was increased following the remote retrieval of morphine-associated memory.	Morphine	228-236	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	151-156
31181370-7	2019	We observed a robust (1.2-2.0x greater than sedentary) increase in tyrosine phosphorylation of AMPA (GluA1,2) and NMDA (GluN2A,B) receptor subunits, and a clear indication that exercise preferentially affects pPKA over pCaMKII.	Tyrosine	67-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	101-108
30328550-4	2019	The aims of the present work were to (1) assess whether extracellular cGMP reverses the alterations in membrane expression of GluA1 and GluA2 in hippocampus of hyperammonemic rats ex vivo and (2) identify the underlying mechanisms.	Cyclic GMP	70-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
31272380-7	2019	Because the IA test is known to be dependent on the long-term potentiation (LTP) of the hippocampus and the trafficking of the GluR1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor into the synapses, the effects of 1.2 MAC desflurane on these phenomena were evaluated on day 1.	Desflurane	256-266	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	127-132
31272380-11	2019	Moreover, immunoblotting analysis of synaptic GluR1 expression revealed that desflurane exposure significantly suppressed GluR1 delivery to the synapses after IA training.	Desflurane	77-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
31272380-11	2019	Moreover, immunoblotting analysis of synaptic GluR1 expression revealed that desflurane exposure significantly suppressed GluR1 delivery to the synapses after IA training.	Desflurane	77-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
31272380-12	2019	CONCLUSION: Exposure to a relatively high concentration of desflurane caused reversible learning and memory impairment in young adult rats associated with suppression of GluR1 delivery to the synapses in the hippocampus.	Desflurane	59-69	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	170-175
30328550-8	2019	Extracellular cGMP also restores membrane expression of GluA1 increasing its phosphorylation at Ser831 because it restores CaMKII membrane association and phosphorylation in Thr286.	Cyclic GMP	14-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
30414958-10	2019	Paclitaxel also upregulated the expression of glutamate receptor subunits GluR1 and NR2B, decreased the expression of K+-Cl- cotransporter, and induced mechanical allodynia in rats.	Paclitaxel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
30498893-8	2019	Here, we show that cocaine SA decreased PrL-NA core spine head diameter, nuclear Fos-IR and pCREB-IR, and GluA1-IR and GluA2-IR in putative mushroom-type spines 2 h after the end of cocaine SA, whereas the opposite occurred following 1 week of abstinence.	cocaine sa	19-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
30747310-6	2019	It is suggested that NR1, NR2A, NR2B and GluR1are involved in learning and memory and that their expression alterations maybe correlated with the occurrence and development of CID in diabetic rats induced by streptozotocin.	Streptozocin	208-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
30881292-10	2019	These findings suggest that perampanel may regulate AMPA receptor functionality via not only blockade of AMPA receptor but also the regulations of multiple molecules (CAMKII, PKA, JNK, and pPP2B)-mediated GluA1 phosphorylations without negative effects on cognition, although the effects of perampanel on PKC, PP1, and PP2A activities were different between normal and epileptic rats.	perampanel	291-301	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	205-210
30508566-6	2019	After the pretreatment of AMPA antagonist (NBQX), PFOS decreased the expression of GluA1 and GluA2 and increased internal cellular calcium at much lower levels than that in the neurons without NBQX treatment.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	43-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
30733663-9	2018	We found that only GluA1 and mGluR5 expression levels were significantly increased after EtOH withdrawal and, in neuroprotection experiments, we observed that AMPA and mGluR5 antagonists attenuated EtOH withdrawal-induced toxicity.	Ethanol	89-93	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
30733663-9	2018	We found that only GluA1 and mGluR5 expression levels were significantly increased after EtOH withdrawal and, in neuroprotection experiments, we observed that AMPA and mGluR5 antagonists attenuated EtOH withdrawal-induced toxicity.	Ethanol	198-202	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
30508566-4	2019	Meanwhile, PFOS decreased the mRNA levels of AMPA receptor subunits GluA1 and GluA2, and the protein amounts in the membrane, with the total GluA1 and GluA2 protein amounts increased, indicating the internalization of AMPA receptors.	perfluorooctane sulfonic acid	11-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-73
30881292-0	2019	Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats.	perampanel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
30881292-2	2019	In normal animals, perampanel affected GluA1 expression/phosphorylation, PKC, CAMKII, PKA, ERK1/2, JNK, and PPs activities.	perampanel	19-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
30881292-4	2019	Perampanel enhanced phospho (p)-GluA1-S831 and -S845 ratios (phosphoprotein/total protein), while it reduced GluA1 expression.	perampanel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
30881292-4	2019	Perampanel enhanced phospho (p)-GluA1-S831 and -S845 ratios (phosphoprotein/total protein), while it reduced GluA1 expression.	perampanel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
30881292-5	2019	Perampanel also increased pCAMKII and pPKA ratios, which phosphorylate GluA1-S831 and -S845 site, respectively.	perampanel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
30881292-6	2019	Perampanel elevated pJNK and pPP2B ratios, which phosphorylates and dephosphorylates both GluA1-S831 and -S845 sits.	perampanel	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
30881292-10	2019	These findings suggest that perampanel may regulate AMPA receptor functionality via not only blockade of AMPA receptor but also the regulations of multiple molecules (CAMKII, PKA, JNK, and pPP2B)-mediated GluA1 phosphorylations without negative effects on cognition, although the effects of perampanel on PKC, PP1, and PP2A activities were different between normal and epileptic rats.	perampanel	28-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	205-210
30858801-10	2019	Bicuculline reverses the changes in membrane expression of AMPA receptor subunits GluA1 and GluA2 and of the NR2B (but not NR1 and NR2A) subunit of NMDA receptors.	Bicuculline	0-11	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
30508566-4	2019	Meanwhile, PFOS decreased the mRNA levels of AMPA receptor subunits GluA1 and GluA2, and the protein amounts in the membrane, with the total GluA1 and GluA2 protein amounts increased, indicating the internalization of AMPA receptors.	perfluorooctane sulfonic acid	11-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	141-146
30508566-5	2019	Furthermore, tests in the primary hippocampal neurons also support the decreased mRNA levels of GluA1 and GluA2 induced by PFOS.	perfluorooctane sulfonic acid	123-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
30508566-6	2019	After the pretreatment of AMPA antagonist (NBQX), PFOS decreased the expression of GluA1 and GluA2 and increased internal cellular calcium at much lower levels than that in the neurons without NBQX treatment.	perfluorooctane sulfonic acid	50-54	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
30189229-5	2018	The present study aimed to investigate the mRNA expression of excitatory amino acid transporters 1-3 (EAATs) and the subunits of the NMDA (GluN1, GluN2a, and GluN2b) and AMPA (GluA1 and GluA2) glutamate receptors following status epilepticus in a rat lithium-pilocarpine model.	lithium-pilocarpine	251-270	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	176-181
30989956-8	2019	At the same time,SPJ could enhance the membrane expression of AMPA receptor( Glu A1 and Glu A2),and increase the expression of p-CAMKIIand p-CREB in aging rats.SPJ could improve cognitive decline of natural aging rats,and its mechanism may be related to regulating NLRP3 inflammasome,thus regulating the membrane expression of AMPA receptor,and enhancing the expression phosphorylation of CAMKII and CREB.	(3R,3'R)-N~1~,N~1~'-butane-1,4-diyldibutane-1,3-diamine	17-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-83
30857476-4	2019	Inhibition of both PKCiota/lambda and downstream substrates p62/GluA1 resulted in male-specific reversals of intramuscular acidic saline-induced allodynia, while female animals continued to display allodynia.	Sodium Chloride	130-136	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	64-69
30092246-5	2018	In the postsynaptic density, cocaine reduced the expression of the NMDA receptor subunits GluN1, GluN2A and GluN2B as well as of the AMPA GluA1 and GluA2 subunits.	Cocaine	29-36	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	138-143
29802834-2	2018	In this study, we investigated the effect of methyl cinnamate (MC), a flavoring agent widely used in food and commodity industry, on CCI-induced upregulation of spinal AMPARs and pain hypersensitive behaviors.	methyl cinnamate	45-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	168-174
29953886-5	2018	Surface and cytosolic glutamate receptor 1 (GluR1) alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression were analyzed using Western blotting.	3-hydroxy-5-methyl-4-isoxazolepropionic	63-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-42
29802834-6	2018	MC treatment reversed CCI-induced upregulation of GluR2, GluR3 and phosphorylation of GluR1.	methyl cinnamate	0-2	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
29802834-2	2018	In this study, we investigated the effect of methyl cinnamate (MC), a flavoring agent widely used in food and commodity industry, on CCI-induced upregulation of spinal AMPARs and pain hypersensitive behaviors.	methyl cinnamate	63-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	168-174
30128074-3	2018	Herein, we describe the discovery, lead optimization, and preclinical characterization of 5-arylbenzimidazolone and oxindole-based negative modulators of AMPARs associated with TARP gamma-8, the primary TARP found in hippocampus.	5-arylbenzimidazolone	90-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-160
29802834-6	2018	MC treatment reversed CCI-induced upregulation of GluR2, GluR3 and phosphorylation of GluR1.	CCI	22-25	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
30044968-3	2018	Synaptic activity and variations in intracellular calcium levels bidirectionally modulate GluA1 transport.	Calcium	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
30044968-4	2018	Chemical long-term potentiation (cLTP) initially induces a halt in GluA1 transport, followed by a sustained increase, while acute glutamate uncaging on synaptic spines arrests vesicular movements.	cltp	33-37	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	67-72
30116207-4	2018	Further mechanistic investigation revealed that repeated sevoflurane exposure impaired long-term potentiation (LTP), downregulated the expression of certain synaptogenesis-related proteins (GluR1, PSD95) and upregulated proteins related to endoplasmic reticulum (ER) stress in the hippocampus.	Sevoflurane	57-68	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	190-195
30104957-0	2018	Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens.	Cocaine	46-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
30104957-0	2018	Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens.	Serine	184-190	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
30104957-2	2018	The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration.	Serine	154-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-126
30104957-2	2018	The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration.	Serine	154-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
30104957-2	2018	The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration.	Cocaine	228-235	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-126
30104957-2	2018	The present study determined if activation of protein kinase G (PKG) contributes to the phosphorylation of AMPA receptor GluA1 subunit at the position of serine 831 (GluA1-S831) in the rat nucleus accumbens (NAc) after repeated cocaine administration.	Cocaine	228-235	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
30104957-4	2018	injections of cocaine (20 mg/kg) once a day for seven consecutive days significantly increased the level of phosphorylated (p)GluA1-S831.	Cocaine	14-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
30104957-6	2018	Repeated cocaine administration increased PKG binding activity to GluA1.	Cocaine	9-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	66-71
30104957-7	2018	This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1.	Cocaine	59-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	17-22
30104957-7	2018	This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1.	Cocaine	59-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
30104957-7	2018	This increase in GluA1-S831 phosphorylation after repeated cocaine administration was decreased by the intra-NAc infusion of the synthetic peptide (Tat-tagged interfering peptide (Tat-GluA1-i)), that interferes with the binding of PKG to GluA1.	Cocaine	59-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
30104957-9	2018	These findings suggest that activated PKG, after repeated exposure to cocaine, binds to AMPA receptor GluA1 and is required for the phosphorylation of S831, contributing to behavioral changes.	Cocaine	70-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	102-107
30128074-3	2018	Herein, we describe the discovery, lead optimization, and preclinical characterization of 5-arylbenzimidazolone and oxindole-based negative modulators of AMPARs associated with TARP gamma-8, the primary TARP found in hippocampus.	2-oxindole	116-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-160
30128074-4	2018	High-throughput screen lead 4 was optimized for potency and brain penetration to provide benzimidazolone 3, JNJ-55511118.1 Replacement of the benzimidazolone core in 3 with an oxindole mitigated reactive metabolite formation and led to the identification of 18 (GluA1/gamma-8 pIC50 = 9.7).	benzimidazolone	89-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	262-267
30128074-4	2018	High-throughput screen lead 4 was optimized for potency and brain penetration to provide benzimidazolone 3, JNJ-55511118.1 Replacement of the benzimidazolone core in 3 with an oxindole mitigated reactive metabolite formation and led to the identification of 18 (GluA1/gamma-8 pIC50 = 9.7).	2-oxindole	176-184	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	262-267
28948570-6	2018	Since GluN2B, via inhibition of ERK, regulates the membrane expression of GluA1, we measured ERK2 phosphorylation in the crude synaptosomal fraction of these brain regions, which was significantly reduced suggesting that ketamine-induced phosphorylation of alphaCaMKII promotes GluN2B (S1303) phosphorylation that, in turn, inhibits ERK 2 signaling, an effect that results in reduced membrane expression and phosphorylation of GluA1.	Ketamine	221-229	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
29578864-10	2018	Protein kinase Mzeta inhibitor reduced remifentanil-induced hyperalgesia, Kalirin-7 expression, and GluA1 trafficking.	Remifentanil	39-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
29578864-14	2018	CONCLUSIONS: Spinal protein kinase Mzeta regulation of GluA1-containing AMPA receptor trafficking and spine morphology via Kalirin-7 overexpression is a fundamental pathogenesis of remifentanil-induced hyperalgesia in rats.	Remifentanil	181-193	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
28948570-6	2018	Since GluN2B, via inhibition of ERK, regulates the membrane expression of GluA1, we measured ERK2 phosphorylation in the crude synaptosomal fraction of these brain regions, which was significantly reduced suggesting that ketamine-induced phosphorylation of alphaCaMKII promotes GluN2B (S1303) phosphorylation that, in turn, inhibits ERK 2 signaling, an effect that results in reduced membrane expression and phosphorylation of GluA1.	Ketamine	221-229	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	427-432
28948570-7	2018	Taken together, our findings point to alphaCaMKII autophosphorylation as a critical signature of ketamine self-administration providing an intracellular mechanism to explain the different effects caused by alphaCaMKII autophosphorylation on the post-synaptic GluN2B- and GluA1-mediated functions.	Ketamine	97-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	271-276
29521680-0	2018	Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration.	Cocaine	94-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
29899033-5	2018	Contrary to a prevailing view on the LTD expression by endocytosis enhancement, the LTD induction by NMDA application only transiently enhanced endocytosis of SEP-tagged GluA1 subunits of AMPAR, which was counteracted by simultaneous augmentation of exocytosis.	N-Methylaspartate	101-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	170-175
29506051-5	2018	By analyzing a P7 rat model of cerebral HI and an in vitro ischemic (oxygen glucose deprivation) model, we found that GSK-3beta inhibitors (GSK-3beta siRNA or lithium chloride) activated mTORC1 signaling, leading to increased expression of synaptic proteins, including synapsin 1, PSD95, and GluR1, and the microtubule-associated protein Tau and decreased expression of the axonal injury-associated protein amyloid precursor protein.	Lithium Chloride	159-175	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	292-297
29723577-6	2018	Exposing Sprague-Dawley rats to CIH for 8 h/day for 3 weeks significantly enhanced the expression level of GluA1 mRNA as well as GluR1 protein in the carotid body.	cih	32-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
29723577-6	2018	Exposing Sprague-Dawley rats to CIH for 8 h/day for 3 weeks significantly enhanced the expression level of GluA1 mRNA as well as GluR1 protein in the carotid body.	cih	32-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
29501527-9	2018	We also found that retigabine alleviated acute stress-induced spatial memory retrieval impairment through adjusting the aberrance of USP2, its upstream regulators (PGC-1alpha, E4BP4 and beta-catenin) and its downstream targets (mTOR, autophagy and GluA1).	ezogabine	19-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	248-253
29317777-1	2018	Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs).	Cocaine	118-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	188-193
29317777-1	2018	Previous work indicated that activation of D1-like dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a process involving the activation of PKA and GluA1-containing AMPA receptors (AMPARs).	Cocaine	118-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	221-227
29317777-8	2018	This viral-mediated attenuation of cocaine reinstatement was accompanied by decreased phosphorylation of GluA1-containing AMPARs and attenuated AMPAR eEPSCs.	Cocaine	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
29317777-8	2018	This viral-mediated attenuation of cocaine reinstatement was accompanied by decreased phosphorylation of GluA1-containing AMPARs and attenuated AMPAR eEPSCs.	Cocaine	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-128
29521680-2	2018	In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microinjections of leptin in this site followed by acute administration of cocaine.	Cocaine	169-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
29521680-3	2018	Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine.	Serine	108-114	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
29521680-3	2018	Interestingly, leptin in the NAcc core significantly blocks the increase of GluA1 phosphorylation levels at serine 845 induced by acute administration of cocaine.	Cocaine	154-161	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
28849293-8	2018	CCI also facilitated miniature excitatory postsynaptic potential of dorsal horn substantia gelatinosa neurons, increased phosphorylation of glutamate receptor subunit GluA1 and synapsin at the synapse, and induced mechanic allodynia.	CCI	0-3	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	167-172
29434817-9	2018	Remifentanil infusion led to upregulation of membrane expression of the AMPAR subunit GluR1 and DOR (P=0.003 and 0.001, respectively) no change in total GluR1 and DOR expression levels (P=0.244 and 0.531, respectively).	Remifentanil	0-12	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
29440309-6	2018	TAK-915 at 10 mg/kg significantly upregulated the phosphorylation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid receptor subunit GluR1 in the rat hippocampus.	TAK-915	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
29432883-4	2018	We found that a systemic injection of a M4 antagonist tropicamide increased AMPA receptor GluA1 subunit phosphorylation at a protein kinase A-dependent site (S845) in the striatum.	Tropicamide	54-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
29432883-11	2018	Blockade of the M4-mediated inhibition significantly augments constitutive and dopamine-stimulated GluA1 S845 phosphorylation.	Dopamine	79-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
29229558-9	2018	Biochemical analysis demonstrated that delta-GABAARs activation by THIP decreased the synaptic expression and phosphorylation of AMPA receptor GluA1 subunit in formalin-injected rats, and meanwhile, increased synaptic GluA2 content, allowing the switch of GluA2-lacking AMPA receptors to GluA2-containing ones at synapses.	gaboxadol	67-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
29242119-3	2018	We found that an agonist selective for Galphas-coupled dopamine D1 receptors, SKF81297, increased AMPA receptor GluA1 subunit phosphorylation at a protein kinase A-sensitive site (S845), while SKF81297 had no effect on GluA1 phosphorylation at S831.	galphas	39-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
29242119-3	2018	We found that an agonist selective for Galphas-coupled dopamine D1 receptors, SKF81297, increased AMPA receptor GluA1 subunit phosphorylation at a protein kinase A-sensitive site (S845), while SKF81297 had no effect on GluA1 phosphorylation at S831.	galphas	39-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	219-224
29242119-3	2018	We found that an agonist selective for Galphas-coupled dopamine D1 receptors, SKF81297, increased AMPA receptor GluA1 subunit phosphorylation at a protein kinase A-sensitive site (S845), while SKF81297 had no effect on GluA1 phosphorylation at S831.	SK and F 81297	78-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
29242119-3	2018	We found that an agonist selective for Galphas-coupled dopamine D1 receptors, SKF81297, increased AMPA receptor GluA1 subunit phosphorylation at a protein kinase A-sensitive site (S845), while SKF81297 had no effect on GluA1 phosphorylation at S831.	SK and F 81297	78-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	219-224
29242119-10	2018	Additionally, coadministered SFK81297 and quinpirole increased the abundance of mPFC GluA1 at extrasynaptic sites.	Quinpirole	42-52	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	85-90
29242119-12	2018	The indirect mechanism involves M4 receptors which generally counteract the effect of dopamine on GluA1 phosphorylation.	Dopamine	86-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
29434817-0	2018	Delta-opioid receptor inhibition prevents remifentanil-induced post-operative hyperalgesia via regulating GluR1 trafficking and AMPA receptor function.	Remifentanil	42-54	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
29434817-2	2018	A previous study by our group suggested that the trafficking and function of glutamate receptor 1 (GluR1) subunits contributes to remifentanil-induced hyperalgesia by regulating the phosphorylation of GluR1 in dorsal horn neurons.	Remifentanil	130-142	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-97
29434817-2	2018	A previous study by our group suggested that the trafficking and function of glutamate receptor 1 (GluR1) subunits contributes to remifentanil-induced hyperalgesia by regulating the phosphorylation of GluR1 in dorsal horn neurons.	Remifentanil	130-142	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
29434817-2	2018	A previous study by our group suggested that the trafficking and function of glutamate receptor 1 (GluR1) subunits contributes to remifentanil-induced hyperalgesia by regulating the phosphorylation of GluR1 in dorsal horn neurons.	Remifentanil	130-142	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	201-206
29422059-10	2018	The changes in membrane expression of GluA1 and GluA2 are reversed by blocking the IL-1 receptor with IL-1Ra or by inhibiting Src with PP2.	pp2	135-138	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
29434817-10	2018	Selective DOR inhibitor naltrindole caused a reduction of remifentanil-induced hyperalgesia, which was accompanied by downregulation of membrane levels of GluR1 in the spinal cord (P=0.0013).	naltrindole	24-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
29434817-13	2018	Combined behavioral, western blot and electrophysiological evidence indicated that remifentanil-induced hyperalgesia was mediated by DOR activation, followed by phosphorylation-dependent GluR1 trafficking and AMPAR function enhancement in the spinal cord.	Remifentanil	83-95	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	187-192
29174736-11	2018	Such findings suggest that GluA1 ser845 phosphorylation may be a trigger event for scopolamine"s actions, and that PKA may represent a novel target for the treatment of depressive symptoms.	Scopolamine	83-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-32
29174736-2	2018	Animal experiments have proven that scopolamine induces mTOR pathway activation in an AMPAR dependent manner.	Scopolamine	36-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
29174736-3	2018	The present study aimed to determine the role of PKA in scopolamine-induced potentiation of AMPAR, as well as in mTOR pathway activation and rapid antidepressant effects.	Scopolamine	56-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
29161812-8	2017	Furthermore, in addition to the increased protein kinase A phosphorylation of the AMPAR subunit GluR1 (an indicator of AMPAR insertion in neurons), treatment with individual optimal doses of d-serine and ketamine also increased adaptin beta2-NMDAR association (an indicator of the intracellular endocytic machinery and subsequent internalization of NMDARs).	D-serine	191-199	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
29174736-4	2018	METHODS: We utilized electrophysiological recording, Western blotting, and behavior tests to examine the effects of scopolamine, the selective M2 cholinergic receptor antagonist methoctramine, and H89, a PKA specific inhibitor on AMPAR potentiation, mTOR pathway activation, and behavioral responses in a rat depression model of learned helplessness.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	197-200	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
29174736-5	2018	RESULTS: Scopolamine (1muM) rapidly increased AMPAR-fEPSP amplitudes and membrane GluA1 expression in CA1 region of hippocampal slices, both of which were abolished by H89.	Scopolamine	9-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
29174736-6	2018	Moreover, scopolamine promoted AMPAR phosphorylation on GluA1 ser845, a PKA site involved in GluA1 membrane insertion.	Scopolamine	10-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	31-36
29174736-6	2018	Moreover, scopolamine promoted AMPAR phosphorylation on GluA1 ser845, a PKA site involved in GluA1 membrane insertion.	Scopolamine	10-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
29174736-6	2018	Moreover, scopolamine promoted AMPAR phosphorylation on GluA1 ser845, a PKA site involved in GluA1 membrane insertion.	Scopolamine	10-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	93-98
29112674-0	2018	Interleukin-10 and PD150606 modulate expression of AMPA receptor GluA1 and GluA2 subunits under hypoxic conditions.	PD 150606	19-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
29107806-7	2018	We show that changes in GluA2 and GluA1 membrane expression in hyperammonemia would be due to enhanced NMDA receptors activation which reduces cGMP levels and phosphodiesterase 2 (PDE2) activity, resulting in increased cAMP levels.	Cyclic GMP	143-147	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	34-39
29107806-7	2018	We show that changes in GluA2 and GluA1 membrane expression in hyperammonemia would be due to enhanced NMDA receptors activation which reduces cGMP levels and phosphodiesterase 2 (PDE2) activity, resulting in increased cAMP levels.	Cyclic AMP	219-223	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	34-39
29196318-0	2018	Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior.	Cocaine	68-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
29196318-1	2018	Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
29196318-1	2018	Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine.	Dopamine	99-107	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
29196318-1	2018	Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine.	Cocaine	163-170	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
29196318-3	2018	In this study, we used viral-mediated expression of a dominant-negative GluN1 subunit (HSV-dnGluN1) in VTA neurons to study the effect of transient NMDAR inactivation on the GluA1 increases induced by chronic cocaine self-administration in male rats.	Cocaine	209-216	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
29196318-4	2018	We found that dnGluN1 expression in the VTA limited to the 3 weeks of cocaine self-administration prevents the subsequent increase in tissue GluA1 levels when compared with control infusions of HSV-LacZ.	Cocaine	70-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	141-146
29196318-7	2018	Together, these data suggest that NMDARs mediate cocaine-induced increases in VTA GluA1 expression, but such transient NMDAR inactivation also leads to compensatory scaling of synaptic AMPA receptors that enhance the motivational for cocaine.SIGNIFICANCE STATEMENT Dopamine neurons in the ventral tegmental area (VTA) are critical substrates of drug rewards.	Cocaine	49-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
29161812-8	2017	Furthermore, in addition to the increased protein kinase A phosphorylation of the AMPAR subunit GluR1 (an indicator of AMPAR insertion in neurons), treatment with individual optimal doses of d-serine and ketamine also increased adaptin beta2-NMDAR association (an indicator of the intracellular endocytic machinery and subsequent internalization of NMDARs).	Ketamine	204-212	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
29019029-8	2017	In addition, PS inhibited the expression levels of GluA1-3 subunits of AMPARs in the offspring hippocampus, while Hippocampal acetylation could reverse this effect by increasing GluA1-3 expression.	ps	13-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
29019029-10	2017	Hippocampal acetylation may improve PS-induced offspring depression-like behavior through the enhanced expression of AMPARs (GluA1-3 subunits).	ps	36-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	125-130
28578480-7	2017	We found that GSM exposure decreased phosphorylation at two residues on the GluA1 AMPAR subunit (serine 831 and 845).	S-methyl glutathione	14-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
28906345-0	2017	Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain.	Folic Acid	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	95-115
28906345-5	2017	Our results showed that CUMS caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-HT concentration, BDNF, and GluR1 expression in the hippocampus and association cortex.	cums	24-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	152-157
28906345-6	2017	In conclusion, the results showed that folic acid significantly improved depression-like behaviors in CUMS-induced rats, and its antidepressant effects might be related to the increase of brain 5-HT concentration, BDNF and GluR1 expression, and repair of synaptic organization in the brain.	Folic Acid	39-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	223-228
28865912-4	2017	Glutamatergic synapses in LHb neurons largely express GluA1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that can be modulated by Ca2+/calmodulin-dependent protein II (CaMKII).	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	26-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
28865912-4	2017	Glutamatergic synapses in LHb neurons largely express GluA1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that can be modulated by Ca2+/calmodulin-dependent protein II (CaMKII).	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	26-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	119-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	119-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	119-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	Ethanol	126-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	Ethanol	126-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
28865912-6	2017	Western blotting revealed a higher level of phosphorylated AMPAR GluA1 subunit at a CaMKII locus (GluA1-Ser831) in the LHb of ethanol-withdrawn rats than that of age-matched naive counterparts.	Ethanol	126-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
28865912-9	2017	These results demonstrate that CaMKII-AMPAR signaling in the LHb exemplifies a molecular basis for depressive-like symptoms during ethanol withdrawal and that inhibition of this signaling pathway may offer a new therapeutic approach to address the comorbidity of alcohol abuse and depression.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	61-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
28865912-9	2017	These results demonstrate that CaMKII-AMPAR signaling in the LHb exemplifies a molecular basis for depressive-like symptoms during ethanol withdrawal and that inhibition of this signaling pathway may offer a new therapeutic approach to address the comorbidity of alcohol abuse and depression.	Ethanol	131-138	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
28578480-7	2017	We found that GSM exposure decreased phosphorylation at two residues on the GluA1 AMPAR subunit (serine 831 and 845).	Serine	97-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
28578480-8	2017	The GSM-induced changes in gene expressions, microglia, and GluA1 phosphorylation did not persist 72 h after RF exposure and were not observed in the absence of LPS pretreatment.	S-methyl glutathione	4-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
28366471-9	2017	Roflumilast treatment (1nM delivered 6h post-injury) significantly increased total AMPA glutamate receptor 1 (GluR1) subunit expression, phosphorylation of the GluR1 subunit at the serine-831 site, and phosphorylation of stargazin at the serine-239/240 site upon LTP induction, measured 24h following injury.	Serine	181-187	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	160-165
28916629-2	2017	We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced GluA1 receptor levels that have been hypothesized to support memory.	trichostatin A	21-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	131-136
28916629-2	2017	We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced GluA1 receptor levels that have been hypothesized to support memory.	trichostatin A	37-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	131-136
28916629-5	2017	Immunoblot analysis showed that GluA1 receptor membrane expression in the olfactory bulbs of the TSA-treated group was significantly increased at 48 h unlike control rats without TSA.	trichostatin A	97-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
28916629-5	2017	Immunoblot analysis showed that GluA1 receptor membrane expression in the olfactory bulbs of the TSA-treated group was significantly increased at 48 h unlike control rats without TSA.	trichostatin A	179-182	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
28412220-5	2017	Levels of GluA1 and GluA4 from dorsal spinal membrane fractions increased in carrageenan-injected rats compared to controls.	Carrageenan	77-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	10-15
28735061-4	2017	We found that CUS in rats induced CRH over-expression accompanied by significant GluR1 up-regulation in the hypothalamic PVN and GluR1 co-localized with CRH in the PVN area.	cus	14-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
28735061-4	2017	We found that CUS in rats induced CRH over-expression accompanied by significant GluR1 up-regulation in the hypothalamic PVN and GluR1 co-localized with CRH in the PVN area.	cus	14-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
28479397-9	2017	However, males and females administered 5 mg/kg ketamine displayed increased protein expression of AMPA receptors (GluA1).	Ketamine	48-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	115-120
28495973-4	2017	Intra-NAc xCT knockdown prevented ceftriaxone from attenuating reinstatement and from upregulating GLT-1 and resulted in increased surface expression of AMPA receptor subunits GluA1 and GluA2.	nac	6-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	176-181
28495973-6	2017	In the absence of cocaine or ceftriaxone treatment, xCT knockdown in the NAc increased the expression of both GluA1 and GluA2 without affecting GLT-1 expression while GLT-1 knockdown had no effect.	nac	73-76	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	110-115
28852612-6	2017	Meanwhile, LTP-related glutamate receptors, NMDA receptor 2A (NR2A) and AMPA receptor 1 (GluR1), are significantly downregulated in BPA-exposed rats.	bisphenol A	132-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
28559974-13	2017	The results of Western blot showed that melatonin attenuated the up-regulation of NR2B-containing N-methyl-D-aspartate receptors, GluR1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor as well as phosphorylation of GluR1 at Ser831, and Ca2+/calmodulin-dependent protein kinase II-alpha in SD rats.	Melatonin	40-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	130-135
28559974-13	2017	The results of Western blot showed that melatonin attenuated the up-regulation of NR2B-containing N-methyl-D-aspartate receptors, GluR1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor as well as phosphorylation of GluR1 at Ser831, and Ca2+/calmodulin-dependent protein kinase II-alpha in SD rats.	Melatonin	40-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	247-252
28223211-4	2017	On the other hand, exposure to amphetamine significantly slowed mEPSC decay times and increased levels in the PSD of PKA and CaMKII as well as phosphorylation by these kinases of the GluA1 S845 and S831 residues selectively in this cellular compartment.	Amphetamine	31-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	183-188
28223211-6	2017	Rather than increase the number of surface and synaptic AMPA receptors as with cocaine, this mechanism could increase NAcc medium spiny neuron reactivity to glutamate afferents by increasing the phosphorylation state of critical regulatory sites in the AMPA receptor GluA1 subunit in the PSD.	nacc medium	118-129	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	267-272
28223211-6	2017	Rather than increase the number of surface and synaptic AMPA receptors as with cocaine, this mechanism could increase NAcc medium spiny neuron reactivity to glutamate afferents by increasing the phosphorylation state of critical regulatory sites in the AMPA receptor GluA1 subunit in the PSD.	Glutamic Acid	157-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	267-272
28092020-10	2017	Notably, minocycline also triggered downregulation of H3K9me2 expression and restored expression of NR1, GluR1, and GluR2.	Minocycline	9-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
27678087-8	2017	Similar effects were detected in cultured rat hippocampal neurons: Acute vortioxetine increased S845 GluA1 phosphorylation without changing S831 GluA1 phosphorylation or the total GluA1 protein level.	Vortioxetine	73-85	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	101-106
27573357-6	2017	Additionally, we observed that primary blast exposure reduced total alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor 1 (GluR1) subunit expression and phosphorylation of the GluR1 subunit at the serine-831 site.	methyl-4-isoxazolepropionic	92-119	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
27573357-6	2017	Additionally, we observed that primary blast exposure reduced total alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor 1 (GluR1) subunit expression and phosphorylation of the GluR1 subunit at the serine-831 site.	Serine	228-234	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
26384129-10	2017	Cocaine self-administration alone decreased total GluA1 and/or pSer845GluA1 expression in basolateral amygdala and nucleus accumbens.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-55
28469656-7	2017	Additionally, 3-methyladenine pretreatment blocked the hypoxia-ischemia-induced upregulation of GluR1 and downregulation of GluR2 in the hippocampus.	3-methyladenine	14-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
28469656-8	2017	By contrast, rapamycin further elevated hippocampal GluR1 levels and exacerbated decreased GluR2 expression levels in neonates with HIBD.	Sirolimus	13-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
27616342-8	2017	Rats that were subjected to SPS exhibited a large increase in pSer845-GluA1 and total GluA1 levels in the mPFC, while no significant change in the NAc.	Sodium phenolsulfonate	28-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
27616342-8	2017	Rats that were subjected to SPS exhibited a large increase in pSer845-GluA1 and total GluA1 levels in the mPFC, while no significant change in the NAc.	Sodium phenolsulfonate	28-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
27189876-9	2017	JZL184 administration significantly attenuated the increased pGluR1S845/GluR1 and pERK 1/2/ERK and the increases in miniature excitatory postsynaptic potential (mEPSC) frequency and amplitude observed in layer 5 pyramidal neurons at 10 days post-TBI.	JZL 184	0-6	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
26384129-10	2017	Cocaine self-administration alone decreased total GluA1 and/or pSer845GluA1 expression in basolateral amygdala and nucleus accumbens.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
26814839-3	2016	The phosphorylation states of specific serine residues on the GluA1 and GluA2 AMPAR subunits are considered critical post-translational modifications that regulate AMPAR activity and subcellular trafficking.	Serine	39-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
27060412-7	2017	In sum, our in vivo data support an existence of a dynamic DA-ACh balance in the striatum which actively modulates GluA1 AMPAR phosphorylation and trafficking.	Dopamine	59-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	115-120
27060412-7	2017	In sum, our in vivo data support an existence of a dynamic DA-ACh balance in the striatum which actively modulates GluA1 AMPAR phosphorylation and trafficking.	Acetylcholine	62-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	115-120
29075535-4	2017	We hypothesized that the PKMzeta-GluR1 pathway in the ACC may be involved in anxiety-like behaviors of chronic inflammatory pain and that the mechanism of EA regulation of pain emotion may involve the PKMzeta pathway in the ACC.	pkmzeta	25-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-38
27796078-0	2016	Withdrawal from Chronic Nicotine Exposure Produces Region-Specific Tolerance to Alcohol-Stimulated GluA1 Phosphorylation.	Nicotine	24-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
27796078-0	2016	Withdrawal from Chronic Nicotine Exposure Produces Region-Specific Tolerance to Alcohol-Stimulated GluA1 Phosphorylation.	Alcohols	80-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
27796078-4	2016	We examined regional neuroadaptations in nicotine-experienced versus nonexperienced animals, focusing on changes in phosphorylation of the AMPA glutamate channel subunit GluA1 in reward-related brain regions as excitatory neuroadaptations are heavily implicated in both alcohol and nicotine addiction.	Alcohols	270-277	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	170-175
27796078-4	2016	We examined regional neuroadaptations in nicotine-experienced versus nonexperienced animals, focusing on changes in phosphorylation of the AMPA glutamate channel subunit GluA1 in reward-related brain regions as excitatory neuroadaptations are heavily implicated in both alcohol and nicotine addiction.	Nicotine	282-290	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	170-175
27796078-5	2016	RESULTS: During withdrawal, nicotine exposure and alcohol challenge (1 g/kg) interactively produced neuroadaptations in GluA1 phosphorylation in a brain region-dependent manner.	Nicotine	28-36	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
27796078-5	2016	RESULTS: During withdrawal, nicotine exposure and alcohol challenge (1 g/kg) interactively produced neuroadaptations in GluA1 phosphorylation in a brain region-dependent manner.	Alcohols	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
27796078-6	2016	Alcohol robustly increased protein kinase A-mediated phosphorylation of GluA1 at serine 845 in multiple regions.	Alcohols	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
27796078-6	2016	Alcohol robustly increased protein kinase A-mediated phosphorylation of GluA1 at serine 845 in multiple regions.	Serine	81-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
27796078-8	2016	This interactive effect suggests a molecular tolerance to alcohol-stimulated phosphorylation of GluA1 in the context of nicotine dependence.	Alcohols	58-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
27796078-8	2016	This interactive effect suggests a molecular tolerance to alcohol-stimulated phosphorylation of GluA1 in the context of nicotine dependence.	Nicotine	120-128	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
27998384-10	2016	CONCLUSION: The RAS PI3K/PKB GluR1 S831 and S845 signal transduction pathway may be involved in the inhibition of hippocampal LTP by aluminum exposure in rats.	Aluminum	133-141	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	29-34
26814839-3	2016	The phosphorylation states of specific serine residues on the GluA1 and GluA2 AMPAR subunits are considered critical post-translational modifications that regulate AMPAR activity and subcellular trafficking.	Serine	39-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	78-83
26814839-3	2016	The phosphorylation states of specific serine residues on the GluA1 and GluA2 AMPAR subunits are considered critical post-translational modifications that regulate AMPAR activity and subcellular trafficking.	Serine	39-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	164-169
26814839-5	2016	Here, we examined the dynamics of phosphorylation at three AMPAR serine residues (ser831-GluA1, ser845-GluA1, and ser880-GluA2) in four brain regions [amygdala, medial prefrontal cortex (mPFC), dorsal hippocampus, and ventral hippocampus] of the rat during the hour following behavioral stress.	Serine	65-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
26957131-9	2016	CONCLUSIONS: Our findings implicate a role for synaptic proteins synapsin-1, postsynaptic density protein 95, and glutamate receptor 1 and medial prefrontal cortex spine density in the antidepressant effects of ketamine in male rats subjected to IS but not in female rats subjected to IS, suggesting dissimilar underlying mechanisms for efficacy of ketamine in the two sexes.	Ketamine	211-219	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-134
26867505-6	2016	LTP causes phosphorylation of Ser-831 on GluA1 subunits of AMPARs that increases the single-channel conductance of AMPARs.	Serine	30-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
27422357-5	2016	At cellular level, the expression of the NMDA receptor subunit, GluN2B, as well as the levels of the AMPA subunits, GluA1 and GluA2, were significantly increased in hippocampal post-synaptic fractions from THC-exposed rats compared to controls.	Dronabinol	206-209	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	116-121
27537764-11	2016	Besides, remifentanil infusion increased the expression of PICK1 mRNA and protein (P < .0001) and the membrane GluR1 and GluR2 internalization in spinal dorsal horn neurons (P < .0011).	Remifentanil	9-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
27345386-9	2016	In addition, LEV treatment can alleviate the SE-induced abnormal GluR1 phosphorylation at Ser(831) site, which may contribute to the rescue of synaptic transmission.	Levetiracetam	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
27345386-9	2016	In addition, LEV treatment can alleviate the SE-induced abnormal GluR1 phosphorylation at Ser(831) site, which may contribute to the rescue of synaptic transmission.	Selenium	45-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
27345386-9	2016	In addition, LEV treatment can alleviate the SE-induced abnormal GluR1 phosphorylation at Ser(831) site, which may contribute to the rescue of synaptic transmission.	Serine	90-93	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
26867505-6	2016	LTP causes phosphorylation of Ser-831 on GluA1 subunits of AMPARs that increases the single-channel conductance of AMPARs.	Serine	30-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-65
26867505-6	2016	LTP causes phosphorylation of Ser-831 on GluA1 subunits of AMPARs that increases the single-channel conductance of AMPARs.	Serine	30-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	115-121
26867505-8	2016	LTP involves the insertion of new AMPARs into the synapse and the internalization of AMPARs is associated with dephosphorylation of Ser-845 on GluA1 and caspase-3 activity.	Serine	132-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	85-91
26867505-8	2016	LTP involves the insertion of new AMPARs into the synapse and the internalization of AMPARs is associated with dephosphorylation of Ser-845 on GluA1 and caspase-3 activity.	Serine	132-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
27225765-5	2016	Here, we show that microinjection of the AMPAR antagonist NBQX into the NAc shell of morphine-dependent rats prevented naloxone-induced conditioned place aversions and decreases in sensitivity to brain stimulation reward, but had no effect on somatic withdrawal signs.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	58-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
27225765-5	2016	Here, we show that microinjection of the AMPAR antagonist NBQX into the NAc shell of morphine-dependent rats prevented naloxone-induced conditioned place aversions and decreases in sensitivity to brain stimulation reward, but had no effect on somatic withdrawal signs.	Morphine	85-93	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
27225765-8	2016	Naloxone decreased the surface/intracellular ratio and synaptosomal membrane levels of NAc GluA1 in morphine-dependent rats, suggesting a compensatory removal of AMPARs from synaptic zones.	Morphine	100-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
27225765-9	2016	Together, these findings indicate that chronic morphine increases synaptic availability of GluA1-containing AMPARs in the NAc, which is necessary for triggering negative-affective states in response to naloxone.	Morphine	47-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
27225765-5	2016	Here, we show that microinjection of the AMPAR antagonist NBQX into the NAc shell of morphine-dependent rats prevented naloxone-induced conditioned place aversions and decreases in sensitivity to brain stimulation reward, but had no effect on somatic withdrawal signs.	Naloxone	119-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
27225765-9	2016	Together, these findings indicate that chronic morphine increases synaptic availability of GluA1-containing AMPARs in the NAc, which is necessary for triggering negative-affective states in response to naloxone.	Morphine	47-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-114
27225765-9	2016	Together, these findings indicate that chronic morphine increases synaptic availability of GluA1-containing AMPARs in the NAc, which is necessary for triggering negative-affective states in response to naloxone.	Naloxone	202-210	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
27225765-6	2016	Using a protein cross-linking approach, we found that the surface/intracellular ratio of NAc GluA1, but not GluA2, increased with morphine treatment, suggesting postsynaptic insertion of GluA2-lacking AMPARs.	Morphine	130-138	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	93-98
27225765-9	2016	Together, these findings indicate that chronic morphine increases synaptic availability of GluA1-containing AMPARs in the NAc, which is necessary for triggering negative-affective states in response to naloxone.	Naloxone	202-210	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-114
27225765-6	2016	Using a protein cross-linking approach, we found that the surface/intracellular ratio of NAc GluA1, but not GluA2, increased with morphine treatment, suggesting postsynaptic insertion of GluA2-lacking AMPARs.	Morphine	130-138	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	201-207
27225765-13	2016	We use a rat model of morphine dependence to show that GluA1 subunits of AMPA glutamate receptors in the nucleus accumbens (NAc), a brain region critical for modulating affective states, are necessary for aversive effects of morphine withdrawal.	Morphine	22-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
27225765-7	2016	Consistent with this, 1-naphthylacetyl spermine trihydrochloride (NASPM), an antagonist of GluA2-lacking AMPARs, attenuated naloxone-induced decreases in sensitivity to brain stimulation reward.	NASPM trihydrochloride	22-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-111
27225765-13	2016	We use a rat model of morphine dependence to show that GluA1 subunits of AMPA glutamate receptors in the nucleus accumbens (NAc), a brain region critical for modulating affective states, are necessary for aversive effects of morphine withdrawal.	Morphine	225-233	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
27225765-14	2016	Using biochemical methods in NAc tissue, we show that morphine dependence increases cell surface expression of GluA1, suggesting that neurons in this area are primed for increased AMPA receptor activation upon withdrawal.	Morphine	54-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
27225765-7	2016	Consistent with this, 1-naphthylacetyl spermine trihydrochloride (NASPM), an antagonist of GluA2-lacking AMPARs, attenuated naloxone-induced decreases in sensitivity to brain stimulation reward.	Naspm	66-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-111
27225765-7	2016	Consistent with this, 1-naphthylacetyl spermine trihydrochloride (NASPM), an antagonist of GluA2-lacking AMPARs, attenuated naloxone-induced decreases in sensitivity to brain stimulation reward.	Naloxone	124-132	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-111
27225765-8	2016	Naloxone decreased the surface/intracellular ratio and synaptosomal membrane levels of NAc GluA1 in morphine-dependent rats, suggesting a compensatory removal of AMPARs from synaptic zones.	Naloxone	0-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
27225765-8	2016	Naloxone decreased the surface/intracellular ratio and synaptosomal membrane levels of NAc GluA1 in morphine-dependent rats, suggesting a compensatory removal of AMPARs from synaptic zones.	Naloxone	0-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	162-168
27118769-10	2016	Increased number of the phosphorylated GluR1-IR cells was observed in the trigeminal spinal subnucleus caudalis of dry-tongue rats, and the number of phosphorylated GluR1-IR cells was significantly reduced in PD98059-administrated rats compared to the vehicle-administrated tongue-dry rats.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	209-216	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
26787483-7	2016	Our results reveal that Al treatment produces a dose-dependent suppression of LTP and decreases in the AMPAR subunits GluR1 and GluR2, in both membrane and total cell extracts.	Aluminum	24-26	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
26700433-7	2016	Since we previously showed that the A1R agonist N(6)-cyclopentyladenosine (CPA) reduced both A1Rs and GluA2/GluA1 AMPARs, we hypothesized that the observed impaired synaptic plasticity in middle-aged brains is regulated by A1R-mediated AMPAR internalization by clathrin-mediated endocytosis.	N(6)-cyclopentyladenosine	48-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
26700433-7	2016	Since we previously showed that the A1R agonist N(6)-cyclopentyladenosine (CPA) reduced both A1Rs and GluA2/GluA1 AMPARs, we hypothesized that the observed impaired synaptic plasticity in middle-aged brains is regulated by A1R-mediated AMPAR internalization by clathrin-mediated endocytosis.	N(6)-cyclopentyladenosine	48-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-120
26700433-7	2016	Since we previously showed that the A1R agonist N(6)-cyclopentyladenosine (CPA) reduced both A1Rs and GluA2/GluA1 AMPARs, we hypothesized that the observed impaired synaptic plasticity in middle-aged brains is regulated by A1R-mediated AMPAR internalization by clathrin-mediated endocytosis.	N(6)-cyclopentyladenosine	75-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
26700433-7	2016	Since we previously showed that the A1R agonist N(6)-cyclopentyladenosine (CPA) reduced both A1Rs and GluA2/GluA1 AMPARs, we hypothesized that the observed impaired synaptic plasticity in middle-aged brains is regulated by A1R-mediated AMPAR internalization by clathrin-mediated endocytosis.	N(6)-cyclopentyladenosine	75-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-120
26700433-8	2016	Following cLTP, we found a significant increase in GluA1 and GluA2 surface expression in young rats, which was blunted in middle-aged brains or in young brains pretreated with CPA.	cltp	10-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
26700433-8	2016	Following cLTP, we found a significant increase in GluA1 and GluA2 surface expression in young rats, which was blunted in middle-aged brains or in young brains pretreated with CPA.	N(6)-cyclopentyladenosine	176-179	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
27038592-6	2016	Incubation with chronic EtOH for 7 days and its removal from the medium induced a significant decrease in GluA1 and GluA2 expression levels; a significant reduction in the expression of synaptophysin and GluN2A was observed only after EtOH withdrawal.	Ethanol	24-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
26961610-5	2016	Treatment of cultured rat cortical neurons with 1 or 10 microM methoxychlor and fenvalerate for 9 days selectively decreased GluR2 protein expression; the expression of other AMPA receptor subunits GluR1, GluR3, and GluR4 did not change under the same conditions.	Methoxychlor	63-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	198-203
26961610-5	2016	Treatment of cultured rat cortical neurons with 1 or 10 microM methoxychlor and fenvalerate for 9 days selectively decreased GluR2 protein expression; the expression of other AMPA receptor subunits GluR1, GluR3, and GluR4 did not change under the same conditions.	fenvalerate	80-91	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	198-203
26455878-4	2016	In EC, we found 4h SD remarkably reduced surface expression of GluA1, while there was an increase in the surface expression of GluA2 and GluA3.	4h	16-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
26626486-2	2016	We recently showed a novel mechanism by which A1R activation with N(6)-cyclopentyl adenosine (CPA) induced GluA1 and GluA2 AMPA receptor (AMPAR) endocytosis and adenosine-induced persistent synaptic depression (APSD) in rat hippocampus.	N(6)-cyclopentyladenosine	66-92	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
26626486-2	2016	We recently showed a novel mechanism by which A1R activation with N(6)-cyclopentyl adenosine (CPA) induced GluA1 and GluA2 AMPA receptor (AMPAR) endocytosis and adenosine-induced persistent synaptic depression (APSD) in rat hippocampus.	N(6)-cyclopentyladenosine	94-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
26626486-2	2016	We recently showed a novel mechanism by which A1R activation with N(6)-cyclopentyl adenosine (CPA) induced GluA1 and GluA2 AMPA receptor (AMPAR) endocytosis and adenosine-induced persistent synaptic depression (APSD) in rat hippocampus.	Adenosine	83-92	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
26674878-6	2015	In contrast, intrathecal administration of BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine) (a novel Fbxo3 inhibitor) prevented SNL-induced Fbxl2 ubiquitination and subsequent TFAF2 de-ubiquitination to ameliorate behavioral allodynia via antagonizing TRAF2/TNIK/GluR1 signaling.	BC-1215	43-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	283-288
26912994-3	2016	The aim of this work was to study the time course of changes in the expression of GluR1 and GluR2 subunits of glutamate amino-acid-3-hydroxy-5-methyl-isoxazol-4-propionic acid (AMPA) receptors in rat hippocampus induced by NMDA intrahippocampal injection.	N-Methylaspartate	223-227	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
26912994-8	2016	In addition, NMDA injection induced distinct changes in GluR1 and GluR2 expression over the time.	N-Methylaspartate	13-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
26639425-6	2016	Moreover, the expression of GluR1 in the IL and NAc remarkably increased after treatment with PEPA during the reinstatement.	nac	48-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
26577399-7	2016	In the dentate gyrus, CPZ at >=0.1% or 0.4% decreased the transcript levels for Gria1, Grin2a and Ptgs2, genes related to the synapse and synaptic transmission, and the number of GRIA1(+) and GRIN2A(+) hilar gamma-aminobutyric acid (GABA)-ergic interneurons and cyclooxygenase-2(+) granule cells.	gamma-Aminobutyric Acid	211-234	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
26577399-7	2016	In the dentate gyrus, CPZ at >=0.1% or 0.4% decreased the transcript levels for Gria1, Grin2a and Ptgs2, genes related to the synapse and synaptic transmission, and the number of GRIA1(+) and GRIN2A(+) hilar gamma-aminobutyric acid (GABA)-ergic interneurons and cyclooxygenase-2(+) granule cells.	gamma-Aminobutyric Acid	236-240	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
26915317-11	2016	Ketamine alone did not affect the betaCaMKII and membrane GluR1 protein expressions in the habenula, but increased membrane GluR1 protein expression in the prefrontal cortex of WKY rats.	Ketamine	0-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	124-129
26915317-13	2016	The underlying mechanisms of imipramine"s anti-depressive effect may be associated with the down-regulation of betaCaMKII and membrane GluR1 in the habenula, as well as the up-regulation of membrane GluR1 in the prefrontal cortex.	Imipramine	29-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	135-140
26915317-13	2016	The underlying mechanisms of imipramine"s anti-depressive effect may be associated with the down-regulation of betaCaMKII and membrane GluR1 in the habenula, as well as the up-regulation of membrane GluR1 in the prefrontal cortex.	Imipramine	29-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	199-204
26674878-6	2015	In contrast, intrathecal administration of BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine) (a novel Fbxo3 inhibitor) prevented SNL-induced Fbxl2 ubiquitination and subsequent TFAF2 de-ubiquitination to ameliorate behavioral allodynia via antagonizing TRAF2/TNIK/GluR1 signaling.	n1,n2-bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine	52-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	283-288
25589145-7	2015	RESULTS: In experiment 1, CPP expression in AL rats was associated with elevated pSer845-GluA1, GluA1, and GluA2 in NAc.	Aluminum	44-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
25349168-2	2015	AMPARs are tetrameric protein complexes that consist of GluA1-4 subunits, of which GluA2 imparts calcium permeability.	Calcium	97-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
25656447-5	2015	CONCLUSIONS AND CLINICAL RELEVANCE: A series of additional protein modifications were observed and in particular, tyrosine and tryptophan nitrations on GluA1 were detected that may raise questions on additional regulation mechanisms for AMPARs in addition to phosphorylations.	Tyrosine	114-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	152-157
25656447-5	2015	CONCLUSIONS AND CLINICAL RELEVANCE: A series of additional protein modifications were observed and in particular, tyrosine and tryptophan nitrations on GluA1 were detected that may raise questions on additional regulation mechanisms for AMPARs in addition to phosphorylations.	Tryptophan	127-137	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	152-157
25656447-5	2015	CONCLUSIONS AND CLINICAL RELEVANCE: A series of additional protein modifications were observed and in particular, tyrosine and tryptophan nitrations on GluA1 were detected that may raise questions on additional regulation mechanisms for AMPARs in addition to phosphorylations.	Tryptophan	127-137	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	237-243
26370265-6	2015	Moreover, an enhanced inward rectification of AMPAR current by nicotine suggested a functional role of calcium permeable and GluA1 containing AMPAR.	Nicotine	63-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	125-130
26370265-8	2015	Finally, the intracellular inclusion of synthetic peptide designed to block GluA1 subunit of AMPAR at CAMKII, PKC or PKA phosphorylation site, as well as corresponding kinase inhibitor, blocked nicotinic augmentation of AMPA/NMDA ratio.	N-Methylaspartate	225-229	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
26370265-9	2015	These results have revealed that nicotine increases AMPAR current by modulating the phosphorylation state of GluA1 which is dependent on alpha7-nAChR and intracellular calcium.	Nicotine	33-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
26370265-9	2015	These results have revealed that nicotine increases AMPAR current by modulating the phosphorylation state of GluA1 which is dependent on alpha7-nAChR and intracellular calcium.	Calcium	168-175	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
26297535-5	2015	Furthermore, Zn administered 3 h before the decapitation increased the level of brain derived neurotrophic factor (BDNF), GluA1 and synapsin I.	Zinc	13-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
26297535-6	2015	An elevated level of GluA1 and synapsin I was still observed 24 h after the Zn treatment, although Zn did not produce any effects in the FST at that time point.	Zinc	76-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	21-26
26098845-8	2015	This is due to reduced activation of soluble guanylate cyclase and the formation of cGMP, leading to lower activation of cGMP-dependent protein kinase and phosphorylation of GluR1 in Ser845, which results in lower insertion of AMPA receptors in the synaptic membrane and a lower magnitude of LTP.	Cyclic GMP	84-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
25589145-7	2015	RESULTS: In experiment 1, CPP expression in AL rats was associated with elevated pSer845-GluA1, GluA1, and GluA2 in NAc.	Aluminum	44-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
25589145-9	2015	In experiment 3, pSer845-GluA1 following a CPP test was higher in NAc synaptic membranes of FR relative to AL rats.	Aluminum	107-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
25589145-11	2015	CONCLUSIONS: Results support a scheme in which pSer845-GluA1 in NAc core underlies expression of cocaine CPP and does so by stabilizing or trafficking Ca(2+)-permeable AMPARs to the synaptic membrane.	Cocaine	97-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
25589145-11	2015	CONCLUSIONS: Results support a scheme in which pSer845-GluA1 in NAc core underlies expression of cocaine CPP and does so by stabilizing or trafficking Ca(2+)-permeable AMPARs to the synaptic membrane.	Cocaine	97-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	168-174
26136945-9	2015	Consistently, GLGZD inhibited ischemia-induced apoptosis and downregulated the expression of GluR1.	glgzd	14-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	93-98
25800309-7	2015	In a biochemical experiment which paralleled the sucrose behavioral experiment, rats with a history of sucrose intake during FR displayed increased abundance of pSer845-GluA1, GluA2, and GluA3 in the NAc PSD relative to rats with a history of FR without sucrose access and rats that had been AL throughout, whether they had a history of episodic sucrose intake or not.	Sucrose	103-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
25800309-7	2015	In a biochemical experiment which paralleled the sucrose behavioral experiment, rats with a history of sucrose intake during FR displayed increased abundance of pSer845-GluA1, GluA2, and GluA3 in the NAc PSD relative to rats with a history of FR without sucrose access and rats that had been AL throughout, whether they had a history of episodic sucrose intake or not.	Sucrose	103-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
25800309-7	2015	In a biochemical experiment which paralleled the sucrose behavioral experiment, rats with a history of sucrose intake during FR displayed increased abundance of pSer845-GluA1, GluA2, and GluA3 in the NAc PSD relative to rats with a history of FR without sucrose access and rats that had been AL throughout, whether they had a history of episodic sucrose intake or not.	Sucrose	103-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
25800309-8	2015	A history of FR, with or without a history of sucrose intake, was associated with increased abundance of GluA1.	Sucrose	46-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
25800309-9	2015	A terminal 15-min bout of sucrose intake produced a further increase in pSer845-GluA1 and GluA2 in subjects with a history of sucrose intake during FR.	Sucrose	26-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
25800309-9	2015	A terminal 15-min bout of sucrose intake produced a further increase in pSer845-GluA1 and GluA2 in subjects with a history of sucrose intake during FR.	Sucrose	126-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
26124936-9	2015	Further studies also observed a significant increase in the expression of GluR1 and NR2B, as well as enhanced glutamatergic transmission in the dorsal horn neurons in rats treated with oxaliplatin.	Oxaliplatin	185-196	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
25689263-16	2015	Thus, amphetamine can upregulate GluA1 phosphorylation and surface trafficking of GluA1 in hippocampal neurons in vivo.	Amphetamine	6-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-38
25689263-16	2015	Thus, amphetamine can upregulate GluA1 phosphorylation and surface trafficking of GluA1 in hippocampal neurons in vivo.	Amphetamine	6-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
25689263-5	2015	We found that AMPH markedly increased phosphorylation of AMPA receptor GluA1 subunits at serine 845 (S845) in the hippocampus.	Amphetamine	14-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
25689263-5	2015	We found that AMPH markedly increased phosphorylation of AMPA receptor GluA1 subunits at serine 845 (S845) in the hippocampus.	Serine	89-95	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
25689263-9	2015	In contrast to S845, serine 831 phosphorylation of GluA1 and serine 880 phosphorylation of GluA2 were not altered by AMPH.	Serine	21-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
25689263-10	2015	In addition, surface expression of hippocampal GluA1 was up-regulated, while the amount of intracellular GluA1 fraction was concurrently reduced in response to AMPH.	Amphetamine	160-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
25689263-13	2015	Acute AMPH administration induces dose-, time-, site-, and subunit-dependent phosphorylation of AMPA receptors and facilitates surface trafficking of GluA1 AMPA receptors in hippocampal neurons in vivo.	Amphetamine	6-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	150-155
25689263-14	2015	Acute injection of amphetamine increased phosphorylation of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunits at a protein kinase A (PKA)-sensitive site (S845) in the rat hippocampus.	Amphetamine	19-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	133-138
25792422-0	2015	Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro.	Glutamic Acid	10-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	45-50
25792422-0	2015	Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro.	Glutamic Acid	10-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
25792422-4	2015	Here, we use real-time quantitative PCR (RT-qPCR), to determine the effect of prolonged glutamate excitotoxicity on the expression of mRNA encoding for GluR1 and AMPA receptor regulatory proteins in dissociated rat retinal cultures that include neuronal (retinal ganglion cell (RGCs)) and glial (Muller) cell populations.	Glutamic Acid	88-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	152-157
25792422-5	2015	mRNA levels of GluR1 and regulators of the GluR1 subunit of AMPA receptors, including Sap97, Cnih2 and Cnih3, decreased following 6, 24 and 48 h incubation with 5 mM glutamate: related regulators not associated with GluR1 were unaffected.	Glutamic Acid	166-175	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
25792422-5	2015	mRNA levels of GluR1 and regulators of the GluR1 subunit of AMPA receptors, including Sap97, Cnih2 and Cnih3, decreased following 6, 24 and 48 h incubation with 5 mM glutamate: related regulators not associated with GluR1 were unaffected.	Glutamic Acid	166-175	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
25792422-5	2015	mRNA levels of GluR1 and regulators of the GluR1 subunit of AMPA receptors, including Sap97, Cnih2 and Cnih3, decreased following 6, 24 and 48 h incubation with 5 mM glutamate: related regulators not associated with GluR1 were unaffected.	Glutamic Acid	166-175	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
25792422-6	2015	In contrast, GluR1 protein, assessed immunohistochemically, was increased in both RGCs and Muller cells after 24 h glutamate exposure: western blotting analysis was inconclusive.	Glutamic Acid	115-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-18
25792422-7	2015	Reductions in mRNA of GluR1 and associated regulators occurred prior to cell death, which was first detected at 24 h, and substantial by 48 h. Exposure to glutamate acutely increased the intracellular calcium concentration in the cultures and by 24 h, reactive oxygen species were increased.	Glutamic Acid	155-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-27
25792422-7	2015	Reductions in mRNA of GluR1 and associated regulators occurred prior to cell death, which was first detected at 24 h, and substantial by 48 h. Exposure to glutamate acutely increased the intracellular calcium concentration in the cultures and by 24 h, reactive oxygen species were increased.	Calcium	201-208	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-27
25792422-7	2015	Reductions in mRNA of GluR1 and associated regulators occurred prior to cell death, which was first detected at 24 h, and substantial by 48 h. Exposure to glutamate acutely increased the intracellular calcium concentration in the cultures and by 24 h, reactive oxygen species were increased.	Reactive Oxygen Species	252-275	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-27
25792422-8	2015	Our data suggest a negative feedback mechanism in retinal cells, that down-regulates transcription of genes encoding GluR1 regulatory proteins in response to glutamate exposure.	Glutamic Acid	158-167	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	117-122
25792422-10	2015	Therapeutic strategies targeting calcium permeable AMPA receptors should take into account that increases in GluR1 protein are not necessarily associated with increases in associated mRNA levels over time.	Calcium	33-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
25746394-9	2015	CONCLUSIONS: Arc/Arg3.1 in the NAc shell mediates the reconsolidation of morphine-associated context memory via up-regulating the level of membrane of GluR1, for which the local activation of the ERK-CREB signal pathway, as an upstream mechanism of Arc/Arg3.1, is required.	Morphine	73-81	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	151-156
25746394-0	2015	NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required.	Morphine	57-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
25475532-2	2015	This change in AMPAR subunit composition leads to an increase in surface expression of GluA2-lacking Ca(2+) /Zn(2+) permeable AMPARs.	Zinc	109-115	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
25746394-6	2015	Intra-NAc shell infusion U0126, an inhibitor of the Mitogen-activated protein kinase kinase (MEK), prevented the retrieval-induced up-regulation of pERK1/2, pCREB, Arc/Arg3.1, and membrane GluR1 immediately after retrieval of morphine CPP.	U 0126	25-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	189-194
25299527-4	2015	Moreover, combining exercise with administration led to increased phosphorylated-Ser831-GluR1.These results suggest that bryostatin-1 facilitated exercise-induced paralysis recovery, which is possibly mediated by synaptic plasticity related to an increase in synaptic transmission efficiency.	bryostatin 1	121-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
24831997-0	2015	Effects of low-dose ketamine combined with propofol on phosphorylation of AMPA receptor GluR1 subunit and GABAA receptor in hippocampus of stressed rats receiving electroconvulsive shock.	Ketamine	20-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
24831997-0	2015	Effects of low-dose ketamine combined with propofol on phosphorylation of AMPA receptor GluR1 subunit and GABAA receptor in hippocampus of stressed rats receiving electroconvulsive shock.	Propofol	43-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
24831997-1	2015	OBJECTIVES: To investigate the effects of low-dose ketamine combined with propofol on the antidepressant efficacy in stressed rats undergoing electroconvulsive shock (ECS) and its impact on phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit glutamate receptor 1 (GluR1) and gamma-aminobutyric acid receptor subunit A (GABAAR).	Ketamine	51-59	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	284-304
24831997-1	2015	OBJECTIVES: To investigate the effects of low-dose ketamine combined with propofol on the antidepressant efficacy in stressed rats undergoing electroconvulsive shock (ECS) and its impact on phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit glutamate receptor 1 (GluR1) and gamma-aminobutyric acid receptor subunit A (GABAAR).	Ketamine	51-59	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	306-311
24831997-10	2015	CONCLUSIONS: Low-dose ketamine combined with propofol may play a role in enhancing the antidepressant efficacy of ECS in stressed rats, ameliorating the cognitive impairment associated with ECS by balancing the expression of p-GluR1 and p-GABAAR in the hippocampus of stressed rats.	Ketamine	22-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	227-232
24831997-10	2015	CONCLUSIONS: Low-dose ketamine combined with propofol may play a role in enhancing the antidepressant efficacy of ECS in stressed rats, ameliorating the cognitive impairment associated with ECS by balancing the expression of p-GluR1 and p-GABAAR in the hippocampus of stressed rats.	Propofol	45-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	227-232
25172309-2	2015	We assessed whether excitotoxicity induced by neonatal treatment with monosodium glutamate in rats at postnatal age of 1, 3, 5, and 7 modifies the hippocampal expression of the NMDAR subunit NR1 and the AMPAR subunits GluR1/GluR2 at postnatal days 8, 10, 12, and 14.	Sodium Glutamate	70-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	203-208
25172309-2	2015	We assessed whether excitotoxicity induced by neonatal treatment with monosodium glutamate in rats at postnatal age of 1, 3, 5, and 7 modifies the hippocampal expression of the NMDAR subunit NR1 and the AMPAR subunits GluR1/GluR2 at postnatal days 8, 10, 12, and 14.	Sodium Glutamate	70-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
25475532-2	2015	This change in AMPAR subunit composition leads to an increase in surface expression of GluA2-lacking Ca(2+) /Zn(2+) permeable AMPARs.	Zinc	109-115	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-132
25281318-6	2015	Adult animals exposed to THC during adolescence also showed increased AMPA gluA1 with no changes in gluA2 subunits.	Dronabinol	25-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	75-80
25716866-4	2015	In the central nucleus of amygdala (CeA), a limbic structure critically involved in the affective dimension of pain, proteins of GluA1 subunits of glutamate AMPA receptors were upregulated during morphine withdrawal, and viral knockdown of CeA GluA1 eliminated the morphine-seeking behavior in withdrawn rats of the pain group.	Morphine	196-204	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
25716866-4	2015	In the central nucleus of amygdala (CeA), a limbic structure critically involved in the affective dimension of pain, proteins of GluA1 subunits of glutamate AMPA receptors were upregulated during morphine withdrawal, and viral knockdown of CeA GluA1 eliminated the morphine-seeking behavior in withdrawn rats of the pain group.	Morphine	265-273	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
25716866-7	2015	These results suggest direct MeCp2 repression of GluA1 function as a likely mechanism for morphine-seeking behavior maintained by long-lasting affective pain after morphine withdrawal.	Morphine	90-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
25716866-7	2015	These results suggest direct MeCp2 repression of GluA1 function as a likely mechanism for morphine-seeking behavior maintained by long-lasting affective pain after morphine withdrawal.	Morphine	164-172	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
25575796-5	2015	In addition, the AMPA receptor subunit GluR1 protein expression at cytomembrane was downregulated, whereas the expression of GluR2 and GluR3 was upregulated after BPV(pic) treatment.	cytomembrane	67-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
25498917-5	2015	Following the neuro-functional abnormality, we detected that SO2 inhalation reduced the expression of Arc and glutamate receptor subunits (GluR1, GluR2, NR1, NR2A, and NR2B) with a concentration-dependent property in comparison to controls.	Sulfur Dioxide	61-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
25126703-7	2014	RESULTS: Membrane AMPAR subunit GluR1 was upregulated in the spinal cord in remifentanil-induced postoperative hyperalgesia rats (275 +- 36.54 [mean +- SD] vs 100 +- 9.53, P = 0.0009).	Remifentanil	76-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
25126703-8	2014	Selective GSK-3beta inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 +- 23.51 vs 119 +- 14.74, P = 0.0027; 254 +- 23.51 vs 124 +- 9.35, P = 0.0032).	Lithium Chloride	32-36	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
25126703-8	2014	Selective GSK-3beta inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 +- 23.51 vs 119 +- 14.74, P = 0.0027; 254 +- 23.51 vs 124 +- 9.35, P = 0.0032).	tdzd	41-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
25126703-8	2014	Selective GSK-3beta inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 +- 23.51 vs 119 +- 14.74, P = 0.0027; 254 +- 23.51 vs 124 +- 9.35, P = 0.0032).	Remifentanil	69-81	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
25126703-11	2014	CONCLUSIONS: These results indicate that amelioration of remifentanil-induced postoperative hyperalgesia by GSK-3beta inhibition is attributed to downregulated AMPAR GluR1 expression in the membrane fraction and inhibition of AMPAR function via altering pGluR1 and Rab5 expression in the spinal dorsal horn.	Remifentanil	57-69	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
24909673-2	2014	Both ketamine and an mGlu2/3 receptor antagonist reportedly increase the expression of GluR1, an AMPA receptor subunit, within 24h, which may account for the sustained enhancement of excitatory synaptic transmission following ketamine administration.	Ketamine	5-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
24532248-9	2014	The results showed that developmental hypothyroxinemia as well as developmental hypothyroidism decreased the phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1) at serine 831 and serine 845 in hippocampal CA1 region.	Serine	174-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	164-169
24532248-12	2014	Taken together, our results suggest that the increased levels of PP1 caused by developmental hypothyroxinemia or hypothyroidism may account for the dephosphorylation of GluR1 at serine 831 and serine 845, which may contribute to HFS-induced LTD in hippocampal CA1 region.	Serine	178-184	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
24909673-2	2014	Both ketamine and an mGlu2/3 receptor antagonist reportedly increase the expression of GluR1, an AMPA receptor subunit, within 24h, which may account for the sustained enhancement of excitatory synaptic transmission following ketamine administration.	Ketamine	226-234	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
24966334-1	2014	The enhanced AMPA receptor phosphorylation at GluA1 serine 831 sites in the central pain-modulating system plays a pivotal role in descending pain facilitation after inflammation, but the underlying mechanisms remain unclear.	Serine	52-58	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
24903590-8	2014	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor GluR1 was co-precipitated with brevican and versican.	hydroxy-	14-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
24966334-3	2014	Western blot analysis showed an increase in GluA1 phosphorylation at Ser-831 but not at Ser-845.	Serine	69-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	44-49
24966334-8	2014	Under the same conditions, blockade of TrkB receptor functions, phospholipase C, or PKC impaired GluA1 phosphorylation at Ser-831 and decreased excitatory postsynaptic currents mediated by GluA2-lacking AMPA receptors.	Serine	122-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
24966334-9	2014	Taken together, these results suggest that epigenetic up-regulation of BDNF by peripheral inflammation induces GluR1 phosphorylation at Ser-831 sites through activation of the phospholipase C-PKC signaling cascade, leading to the trafficking of GluA1 to pain-modulating neuronal synapses.	Serine	136-139	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
24820113-7	2014	Furthermore, maternal BPA exposure decreased the mRNA and protein expressions of synaptophysin, PSD-95, spinophilin, GluR1 and NMDAR1 in the hippocampus of male offspring on PND 21.	bisphenol A	22-25	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	117-122
25017011-2	2014	miR-92a strongly repressed the translation of GluA1 receptors by binding the 3" untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5.	Tetrodotoxin	210-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
25017011-2	2014	miR-92a strongly repressed the translation of GluA1 receptors by binding the 3" untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5.	Tetrodotoxin	210-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
25017011-2	2014	miR-92a strongly repressed the translation of GluA1 receptors by binding the 3" untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5.	Tetrodotoxin	210-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	128-133
24535653-8	2014	RESULTS: FR increased GluA1 in the PSD, and D-amphetamine increased p-Ser845-GluA1, GluA1, GluA2, but not GluA3, with a greater effect in FR than AL rats.	Dextroamphetamine	44-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-82
24535653-8	2014	RESULTS: FR increased GluA1 in the PSD, and D-amphetamine increased p-Ser845-GluA1, GluA1, GluA2, but not GluA3, with a greater effect in FR than AL rats.	Dextroamphetamine	44-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-82
24535653-11	2014	The D-amphetamine-induced increase in synaptic p-Ser845-GluA1, GluA1, and GluA2 may contribute to the rewarding effect of D-amphetamine, but may also be a mechanism of synaptic strengthening and behavior modification.	Dextroamphetamine	4-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
24535653-11	2014	The D-amphetamine-induced increase in synaptic p-Ser845-GluA1, GluA1, and GluA2 may contribute to the rewarding effect of D-amphetamine, but may also be a mechanism of synaptic strengthening and behavior modification.	Dextroamphetamine	4-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
24535653-11	2014	The D-amphetamine-induced increase in synaptic p-Ser845-GluA1, GluA1, and GluA2 may contribute to the rewarding effect of D-amphetamine, but may also be a mechanism of synaptic strengthening and behavior modification.	Dextroamphetamine	122-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
24535653-11	2014	The D-amphetamine-induced increase in synaptic p-Ser845-GluA1, GluA1, and GluA2 may contribute to the rewarding effect of D-amphetamine, but may also be a mechanism of synaptic strengthening and behavior modification.	Dextroamphetamine	122-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
25031403-5	2014	Using biotinylation and membrane fractionation assays, prolonged CPA incubation showed significant depletion of GluA2/GluA1 surface expression from hippocampal brain slices and cultured neurons.	N(6)-cyclopentyladenosine	65-68	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
25031403-6	2014	Tat-GluA2-3Y peptide or dynamin inhibitor Dynasore prevented CPA-induced GluA2/GluA1 internalization.	N(6)-cyclopentyladenosine	61-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	79-84
25031403-9	2014	Tat-GluA2-3Y peptide or A1R antagonist 8-cyclopentyl-1,3-dipropylxanthine also prevented hypoxia-mediated GluA2/GluA1 internalization.	1,3-dipropyl-8-cyclopentylxanthine	39-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
24239129-7	2014	Chromatin immunoprecipitation-polymerase chain reaction revealed that METH decreased enrichment of acetylated histone H4 on GluA1, GluA2, and GluN1 promoters.	Methamphetamine	70-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	124-129
24239129-8	2014	Methamphetamine exposure also increased repressor element-1 silencing transcription factor (REST) corepressor 1, methylated CpG binding protein 2, and histone deacetylase 2 enrichment, but not of sirtuin 1 or sirtuin 2, onto GluA1 and GluA2 gene sequences.	Methamphetamine	0-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	225-230
24239129-10	2014	Surprisingly, methylated DNA immunoprecipitation and hydroxymethylated DNA immunoprecipitation-polymerase chain reaction revealed METH-induced decreased enrichment of 5-methylcytosine and 5-hydroxymethylcytosine at GluA1 and GluA2 promoter sequences.	Methamphetamine	130-134	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	215-220
24966661-8	2014	At 8 weeks of diabetes, the content of GluA1 phosphorylated at serine 831 or serine 845 in the retina increased, compared to age-matched controls.	Serine	63-69	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
24662915-7	2014	After intraperitoneal administration with 7,8-DHF (5 mg/kg) once daily for a consecutive 14days, we found that chronic 7,8-DHF treatment significantly enhanced the activation of phosphorylated TrkB at the Y515 and Y816 sites, increased the phosphorylation levels of TrkB downstream signal cascades including ERK1/2, CaMKII, CREB and GluR1, and promoted hippocampal synaptic plasticity, which in turn rescued performance in spatial working learning.	6,7-dihydroxyflavone	119-126	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	333-338
24966661-8	2014	At 8 weeks of diabetes, the content of GluA1 phosphorylated at serine 831 or serine 845 in the retina increased, compared to age-matched controls.	Serine	77-83	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
24469593-7	2014	Rapamycin reduced drug seeking in signaled non-drug-available periods, PR responding, and cue-induced reinstatement, with these effects linked to reduced mTORC1 activity, total CAMKIIalpha, and GluA1 AMPAR levels in the NACsh.	Sirolimus	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	194-199
24469593-9	2014	These effects appear to involve a role for mTORC1 in the regulation of GluA1 AMPARs and CAMKIIalpha in the NACsh.	nacsh	107-112	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
24884762-13	2014	The tetraethylammonium-induced GluR1 phosphorylation and trafficking were abolished in the hippocampal slices of rats after surgery.	Tetraethylammonium	4-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	31-36
24884762-15	2014	The incubation of control hippocampal slices with IL-1beta and IL-6 abolished tetraethylammonium-induced GluR1 trafficking and phosphorylation.	Tetraethylammonium	78-96	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
24884762-16	2014	Lidocaine minimally affected the effects of IL-1beta on GluR1 trafficking.	Lidocaine	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
24847227-3	2014	The study also examined, by immunoblotting, whether acquisition and expression of lithium-induced CTA resulted in modified levels of phosphorylation of glutamate receptor subunits (NR1 and GluR1) and Thr(34)- and Thr(75-Dopamine-and-cAMP-Regulated) PhosphoProtein (DARPP-32).	Lithium	82-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	189-194
24712995-8	2014	Supporting this hypothesis, decreasing BDNF signaling with the extracellular BDNF scavenger TrkB-Fc prevented the scaling down of GluA1 and GluA2 surface levels in NAc neurons normally produced by bicuculline.	Bicuculline	197-208	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	130-135
24275700-6	2014	Accordingly, we demonstrated that chronic LiCl, but not aripiprazole, decreased phosphorylation of CREB at the Ser133 site and NA1 at the Ser896 site in the prefrontal cortex and GluA1 at the Ser831 site and NA2B at the Ser1303 site in the ventral striatum.	Lithium Chloride	42-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	179-184
24748330-7	2014	Western blot analysis of the DRGs revealed that CCI resulted in a 35% increase in GluA1 and a 60% decrease in GluA2, the AMPA receptor subunits, compared to uninjured controls.	CCI	48-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
24561222-7	2014	We also confirmed that elevated CaMKII autophosphorylation in the mPFC causes increased phosphorylation of the CaMKII substrate alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid-type glutamate receptor subunit 1 (GluR1) (Ser-831).	Serine	227-230	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	189-217
24561222-7	2014	We also confirmed that elevated CaMKII autophosphorylation in the mPFC causes increased phosphorylation of the CaMKII substrate alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid-type glutamate receptor subunit 1 (GluR1) (Ser-831).	Serine	227-230	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	219-224
24625397-6	2014	RESULTS: Acute Al treatment produced dose-dependent suppression of LTP in the rat hippocampus and dose-dependent decreases of GluR1 and GluR2 in membrane extracts; however, no similar changes were found in the total cell extracts, which suggests decreased trafficking of AMPA receptor subunits from intracellular pools to synaptic sites in the hippocampus.	Aluminum	15-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
24342568-6	2014	Moreover, muscimol infused into CA1 before extinction training resulted in impaired extinction and down-regulation of NR2B activity and phosphorylated GluR1 (at Ser845) in CA1, and the expression levels of NR2B and GluR1 were decreased significantly in the basolateral amygdala (BLA).	Muscimol	10-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	151-156
24342568-6	2014	Moreover, muscimol infused into CA1 before extinction training resulted in impaired extinction and down-regulation of NR2B activity and phosphorylated GluR1 (at Ser845) in CA1, and the expression levels of NR2B and GluR1 were decreased significantly in the basolateral amygdala (BLA).	Muscimol	10-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	215-220
24345425-6	2014	These changes were associated with increased activation of the trkB-Akt pathway resulting in enhanced pmTOR and pS6 kinase, which ultimately produced an up-regulation of Arc and a consequent reduction of GluA1 expression in the mPFC of PD 90 cocaine-treated rats.	Cocaine	242-249	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	204-209
24501347-6	2014	Pharmacological and genetic manipulation of the cells, in combination with fluorescence-recovery-after-photobleaching experiments, revealed that nicotine, acting through alpha7-containing nicotinic acetylcholine receptors on the postsynaptic neuron, induces the stabilization and accumulation of GluA1-containing AMPA receptors on dendritic spines.	Nicotine	145-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	296-301
24231469-0	2014	Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration.	Amphetamine	118-129	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	20-25
24381264-1	2014	Serine phosphorylation of AMPA receptor (AMPAR) subunits GluA1 and GluA2 modulates AMPAR trafficking during long-term changes in strength of hippocampal excitatory transmission required for normal learning and memory.	Serine	0-6	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
24201449-0	2014	Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration.	Morphine	126-134	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	31-51
24201449-2	2014	Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin.	Cocaine	157-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-35
24201449-2	2014	Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin.	Cocaine	157-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
24201449-2	2014	Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin.	Methamphetamine	166-181	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-35
24201449-2	2014	Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin.	Methamphetamine	166-181	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
24201449-4	2014	In our present study, alterations in GluR1 expression and GluR1 phosphorylation at serine 845 (Ser845) and serine 831 (Ser831) in multiple limbic brain regions of rats were measured following context-induced drug craving after 1 or 10 days of withdrawal from intravenous morphine self-administration.	Serine	83-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
24201449-7	2014	These results suggest that time-dependent and region-specific changes in phosphorylation of GluR1 at Ser845, but not Ser831, are involved in the drug-seeking behavior elicited by re-exposure to the morphine-associated context.	Morphine	198-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
24231469-3	2014	By phosphorylating specific serine resides in AMPA receptor subunits (GluA1 and GluA2), various protein kinases regulate subcellular/subsynaptic expression and function of the receptor.	Serine	28-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
24231469-6	2014	We found that acute injection of amphetamine induced a rapid and relatively sustained increase in GluA1 S845 phosphorylation at both synaptic and extrasynaptic sites in the striatum.	Amphetamine	33-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
23974710-0	2013	GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal.	Serine	25-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
24377717-6	2014	Two drugs that prevent radiation-induced cognitive impairment in rats, the angiotensin type-1 receptor blocker, L-158,809, and the angiotensin converting enzyme inhibitor, ramipril, reversed the fractionated whole-brain irradiation-induced Homer1a expression at 48 h in the hippocampus and cortex and restored glutamate receptor 1 and protein kinase Cgamma to the levels in sham-irradiated controls at 2 months after fractionated whole-brain irradiation.	l-158	112-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	310-330
24377717-6	2014	Two drugs that prevent radiation-induced cognitive impairment in rats, the angiotensin type-1 receptor blocker, L-158,809, and the angiotensin converting enzyme inhibitor, ramipril, reversed the fractionated whole-brain irradiation-induced Homer1a expression at 48 h in the hippocampus and cortex and restored glutamate receptor 1 and protein kinase Cgamma to the levels in sham-irradiated controls at 2 months after fractionated whole-brain irradiation.	Ramipril	172-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	310-330
24285907-6	2013	We find, in addition, that this increase in GluA1 levels leads to the formation of calcium-permeable AMPA receptors (CPARs).	Calcium	83-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	44-49
24285907-6	2013	We find, in addition, that this increase in GluA1 levels leads to the formation of calcium-permeable AMPA receptors (CPARs).	cpars	117-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	44-49
24967301-5	2013	Results indicate that, during nasal stimulation with ammonia vapors in urethane-anesthetized Sprague-Dawley rats, activated neurons within the superficial MDH coexpress the AMPA glutamate receptor subunits GluA1 (95.8%) and GluA2/3 (88.2%), the NMDA glutamate receptor subunits GluN1 (89.1%) and GluN2A (41.4%), and NK1 receptors (64.0%).	Ammonia	53-60	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	206-211
24967301-5	2013	Results indicate that, during nasal stimulation with ammonia vapors in urethane-anesthetized Sprague-Dawley rats, activated neurons within the superficial MDH coexpress the AMPA glutamate receptor subunits GluA1 (95.8%) and GluA2/3 (88.2%), the NMDA glutamate receptor subunits GluN1 (89.1%) and GluN2A (41.4%), and NK1 receptors (64.0%).	Urethane	71-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	206-211
24118589-8	2013	CONCLUSIONS & INFERENCES: The underlying mechanism of acid-induced cortical sensitization involves upregulation and CaMKII-mediated phosphorylation of GluA1.	Adenosine Monophosphate	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
24079996-0	2013	Different locomotor sensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats.	Cocaine	56-63	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	127-132
24392579-6	2013	GluR1 immunoreactivity of the soma and cell processes indicates that Lugaro cells have functional ionotropic glutamate receptors that regulate calcium levels.	Calcium	143-150	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
23747591-0	2013	Regulation of phosphorylation of synaptic and extrasynaptic GluA1 AMPA receptors in the rat forebrain by amphetamine.	Amphetamine	105-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
23747591-6	2013	We found that acute AMPH administration elevated GluA1 S845 phosphorylation in the defined synaptic membrane from the striatum in a dose-dependent manner.	Amphetamine	20-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
23747591-7	2013	AMPH also induced a comparable increase in S845 phosphorylation in the extrasynaptic fraction of striatal GluA1.	Amphetamine	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
23747591-9	2013	In contrast, S831 phosphorylation was not altered in synaptic and extrasynaptic GluA1 in striatal neurons and synaptic GluA1 in mPFC neurons in response to AMPH, although a moderate increase in S831 phosphorylation was seen in extrasynaptic GluA1 in the mPFC after an AMPH injection at a high dose.	Amphetamine	156-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
23747591-9	2013	In contrast, S831 phosphorylation was not altered in synaptic and extrasynaptic GluA1 in striatal neurons and synaptic GluA1 in mPFC neurons in response to AMPH, although a moderate increase in S831 phosphorylation was seen in extrasynaptic GluA1 in the mPFC after an AMPH injection at a high dose.	Amphetamine	156-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
23747591-12	2013	S845 is a primary site where phosphorylation of GluA1 is upregulated by AMPH in striatal and mPFC neurons at both synaptic and extrasynaptic compartments.	Amphetamine	72-76	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	48-53
23711322-5	2013	Acute morphine decreased GluA1 and GluA2 surface expression in mPFC and GluA1 in NAc.	Morphine	6-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
23711322-5	2013	Acute morphine decreased GluA1 and GluA2 surface expression in mPFC and GluA1 in NAc.	Morphine	6-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
23603403-9	2013	In addition, there was a selective decrease in AMPAR phosphorylation levels at serine site 831 but not 845 on the GluR1 subunit ipsilaterally with a trend toward a decrease contralaterally.	Serine	79-85	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	47-52
23603403-9	2013	In addition, there was a selective decrease in AMPAR phosphorylation levels at serine site 831 but not 845 on the GluR1 subunit ipsilaterally with a trend toward a decrease contralaterally.	Serine	79-85	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
23296627-4	2013	The mRNAs encoding all four AMPAR subunits were detected in the somata and dendrites of CA3 and CA1 pyramidal cells and those of six classes of CA1 gamma-aminobutyric acid (GABA)ergic interneurons.	gamma-Aminobutyric Acid	173-177	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
23583340-0	2013	Protein kinase G increases AMPA receptor GluR1 phosphorylation at serine 845 after repeated cocaine administration in the rat nucleus accumbens.	Serine	66-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
23583340-0	2013	Protein kinase G increases AMPA receptor GluR1 phosphorylation at serine 845 after repeated cocaine administration in the rat nucleus accumbens.	Cocaine	92-99	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	24-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	24-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	136-141
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	Serine	124-130	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	Serine	124-130	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	136-141
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	Cocaine	250-257	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
23583340-1	2013	The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration.	Cocaine	250-257	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	136-141
23583340-3	2013	The inhibition of PKG also attenuated Ca(2+)-calmodulin-dependent protein kinases II (CaMKII) phosphorylation, however inhibition of CaMKII with KN62 (20 nmol) did not alter the phosphorylation state of GluR1-Ser845.	KN 62	145-149	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	203-208
23583340-5	2013	These findings suggest that the AMPA receptor provides a PKG-sensitive phosphorylation site on GluR1-Ser845 in the NAc after repeated cocaine, thus contributing to behavioral alterations.	Cocaine	134-141	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	95-100
23494293-7	2013	Our results suggest the presence of an attenuation of AMPARs" post-synaptic excitatory response to glutamate after PILO treatment, thus conferring neuronal protection from the excitotoxic conditions observed in the SE.	Glutamic Acid	99-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-60
23551217-5	2013	Moreover, DCS administration significantly increased GluA1, GluN1, GluN2A, and GluN2B expression in the mPFC.	Cycloserine	10-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	53-58
22999489-7	2013	Furthermore, PPT treatment also improved ovariectomy-induced hippocampal synapse loss and up-regulated the levels of synaptic proteins (synapsin I, NR2A and GluR1) and the activates of CaMK Pialpha, ERK and Akt.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	157-162
23490331-6	2013	Unexpectedly, we found a significant increase in the phosphorylation of synapsin I (Ser 603) and GluR1 (Ser 831) in the same experiment.	Serine	104-107	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
23334104-0	2013	Activation of protein kinase C is required for AMPA receptor GluR1 phosphorylation at serine 845 in the dorsal striatum following repeated cocaine administration.	Serine	86-92	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	61-66
23334104-0	2013	Activation of protein kinase C is required for AMPA receptor GluR1 phosphorylation at serine 845 in the dorsal striatum following repeated cocaine administration.	Cocaine	139-146	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	61-66
23334104-2	2013	OBJECTIVES: It is well known that phosphorylation of AMPA receptor GluR1 subunit at serine 845 (S845) is regulated by protein kinase A downstream to dopamine D1 receptors in the striatum.	Serine	84-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	67-72
23334104-3	2013	This study was performed to determine whether GluR1-S845 phosphorylation in the rat dorsal striatum is altered by repeated cocaine via a signaling mechanism involving glutamate receptor-associated and Ca(2+)-dependent protein kinases.	Cocaine	123-130	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
23334104-4	2013	RESULTS: Systemic administration of cocaine (20 mg/kg, once a day for 7 days) upregulated GluR1-S845 phosphorylation.	Cocaine	36-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
23334104-8	2013	CONCLUSIONS: These findings suggest that phosphorylation of AMPA receptors at GluR1-S845 is upregulated by interactions of glutamate receptor-coupled Ca(2+)-dependent protein kinases following repeated cocaine administration in the dorsal striatum.	Cocaine	202-209	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	78-83
23085477-5	2013	Phosphorylation of GluA1 at Ser(845) was increased in the vmPFC and nucleus accumbens (NAc).	Serine	28-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
23303054-5	2013	Cell surface biotinylation studies showed that both GLYX-13 and ketamine led to increases in both NR2B and GluR1 protein levels, as measured by Western analysis, whereas no changes were seen in mRNA expression (microarray and qRT-PCR).	GLYX-13 peptide	52-59	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
23303054-5	2013	Cell surface biotinylation studies showed that both GLYX-13 and ketamine led to increases in both NR2B and GluR1 protein levels, as measured by Western analysis, whereas no changes were seen in mRNA expression (microarray and qRT-PCR).	Ketamine	64-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
23352852-0	2013	Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naive rats, but not cocaine-experienced rats.	Cocaine	6-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
23352852-1	2013	Transport of GluA1-containing AMPA glutamate receptors to synapses in the nucleus accumbens, a process that involves phosphorylation of key serine residues by CaMKII, is associated with the reinstatement of cocaine-seeking behavior.	Serine	140-146	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-18
23352852-1	2013	Transport of GluA1-containing AMPA glutamate receptors to synapses in the nucleus accumbens, a process that involves phosphorylation of key serine residues by CaMKII, is associated with the reinstatement of cocaine-seeking behavior.	Cocaine	207-214	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-18
23352852-11	2013	These results indicate that acute exposure to cocaine in drug naive rats increased CaMKII-mediated phosphorylation of GluA1-containing AMPA receptors in the DL striatum, an effect that was not observed during cocaine priming-induced reinstatement of drug seeking.	Cocaine	46-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
23352852-12	2013	It is possible; therefore, that increased phosphorylation of CaMKII and GluA1 following acute cocaine is a compensatory mechanism in the DL striatum.	Cocaine	94-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
23354537-8	2013	Rats that expressed a persistent CPP had elevated levels of p-ERK1, GluA1, and p-Ser845-GluA1 in NAc core, and the latter correlated with CPP expression.	nac	97-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
23554493-4	2013	We report that in rat, repeated daily ingestion of a 25% sucrose solution transiently elevated spontaneous locomotion and potentiated accumbens core synapses through incorporation of Ca(2+)-permeable AMPA receptors (CPARs), which are GluA1-containing, GluA2-lacking AMPARs.	Sucrose	57-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	234-239
23554493-4	2013	We report that in rat, repeated daily ingestion of a 25% sucrose solution transiently elevated spontaneous locomotion and potentiated accumbens core synapses through incorporation of Ca(2+)-permeable AMPA receptors (CPARs), which are GluA1-containing, GluA2-lacking AMPARs.	Sucrose	57-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	266-272
23554493-5	2013	Electrophysiological, biochemical, and quantitative electron microscopy studies revealed that sucrose training (7 d) induced a stable (>24 h) intraspinous GluA1 population, and that in these rats a single sucrose stimulus rapidly (5 min) but transiently (<24 h) elevated GluA1 at extrasynaptic sites.	Sucrose	94-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	158-163
23554493-5	2013	Electrophysiological, biochemical, and quantitative electron microscopy studies revealed that sucrose training (7 d) induced a stable (>24 h) intraspinous GluA1 population, and that in these rats a single sucrose stimulus rapidly (5 min) but transiently (<24 h) elevated GluA1 at extrasynaptic sites.	Sucrose	94-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	277-282
23554493-7	2013	Significantly, a 7 d protocol of daily ingestion of a 3% solution of saccharin, a noncaloric sweetener, induced synaptic GluA1 similarly to 25% sucrose ingestion.	Saccharin	69-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-126
23392471-2	2013	It has been demonstrated in this model that the phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit is increased 1 h after pilocarpine treatment.	-3-hydroxy-5-methyl-4-isoxazolepropionic acid	82-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
23392471-2	2013	It has been demonstrated in this model that the phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit is increased 1 h after pilocarpine treatment.	Pilocarpine	181-192	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	65-68	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	65-68	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	65-68	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	95-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	95-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
23392471-8	2013	Key findings include an increase in the phosphorylation of GluR1-Ser(845) in the Ctx and GluR1-Ser(831) in the Hip at different times during the acute period, and a decrease in the total content of the GluR1 subunit in the Ctx in the latent period.	Serine	95-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
23360446-3	2013	This was accomplished by a combination of behavioral pharmacology, microdialysis measures of extracellular dopamine and glutamate, and Western blotting for GluR1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor (AMPAR).	methyl radical	201-207	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	156-161
23360446-3	2013	This was accomplished by a combination of behavioral pharmacology, microdialysis measures of extracellular dopamine and glutamate, and Western blotting for GluR1 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor (AMPAR).	4-isoxazolepropionic acid	208-233	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	156-161
23360446-7	2013	Further implicating glutamate, the locomotor response to AMPAR stimulation in the core was potentiated, but not in the shell of pre-stressed animals, and this was accompanied by an increase in NAc GluR1 surface expression.	Glutamic Acid	20-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	197-202
23983471-9	2013	Phosphorylated levels of GluR1 at Serine-845 (pGluR1S845) levels were determined by western blot.	Serine	34-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
23345231-3	2013	In CeA neurons, we found that CeA GluA1 expression was significantly increased 2 h after conditioning treatment with morphine, but not 24 h after the conditioning when the behavior of conditioned place reference (CPP) was fully established in rats.	Morphine	117-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	34-39
23345231-4	2013	Adenoviral overexpression of GluA1 subunits in CeA accelerated associative learning, as shown by reduced minimum time of morphine conditioning required for CPP acquisition and by facilitated CPP extinction through extinction training with no morphine involved.	Morphine	121-129	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	29-34
23345217-1	2013	Amphetamine exposure transiently increases Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) alpha expression in the nucleus accumbens (NAcc) shell and this persistently increases local GluA1 S831 phosphorylation and enhances behavioral responding to the drug.	Amphetamine	0-11	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	191-196
23345217-4	2013	Remarkably, this transient inhibition of CaMKII activity produced a long-lasting reversal of the increased GluA1 S831 phosphorylation levels in NAcc shell and persistently blocked the enhanced locomotor response to and self-administration of amphetamine normally observed in rats previously exposed to the drug.	Amphetamine	242-253	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
24381641-11	2013	XYS decoction and CNQX showed significant improvement behavioral changes and the ultrastructural damage of the hippocampus CA1; XYS decoction also reversed CIS-induced decreases in GluR2 mRNA and increases in GluR1 mRNA in the hippocampus CA1 as well as CNQX.	6-Cyano-7-nitroquinoxaline-2,3-dione	18-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	209-214
23271319-10	2013	Furthermore, PMQ significantly activated the Akt/cAMP response element-binding protein pathway and increased the expression of memory-related proteins in the downstream part of the Akt/cAMP response element-binding protein pathway, such as synaptophysin and glutamate receptor 1.	pmq	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	258-278
23223299-2	2012	We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target.	Serine	107-113	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
23117296-0	2013	Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002.	Fatty Acids, Nonesterified	73-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	14-19
23223299-2	2012	We showed previously that hypoxia-induced seizures in a neonatal rat model induce rapid phosphorylation of serine-831 (S831) and Serine 845 (S845) sites of the AMPA receptor GluR1 subunit and later neuronal hyperexcitability and epilepsy, suggesting that seizure-induced posttranslational modifications may represent a novel therapeutic target.	Serine	129-135	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
22243518-5	2012	As the study progressed, our aims grew to include the question, whether carrageenan-induced GluA1 subunit trafficking was downstream of Akt phosphorylation.	Carrageenan	72-83	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
22980744-6	2012	GSK-650394 (an SGK1 activation antagonist, 1, 10, and 30 muM, 10 muL/rat, intrathecally) dose-dependently prevented CFA-induced pain behavior and the associated SGK1 phosphorylation, GluR1 trafficking, and protein-protein interactions at 1 day after CFA administration.	2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic acid	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	183-188
22980744-7	2012	Intrathecal 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, an AMPAR antagonist, 1, 3, and 10 muM, 10 muL/rat) attenuated the hyperalgesia and GluR1 trafficking caused by CFA; however, it had no effect on SGK1 phosphorylation.	6-Cyano-7-nitroquinoxaline-2,3-dione	12-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
22980744-7	2012	Intrathecal 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, an AMPAR antagonist, 1, 3, and 10 muM, 10 muL/rat) attenuated the hyperalgesia and GluR1 trafficking caused by CFA; however, it had no effect on SGK1 phosphorylation.	6-Cyano-7-nitroquinoxaline-2,3-dione	50-54	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
23100433-7	2012	Importantly, we report that inhibition of AMPARs in the DMS attenuates operant self-administration of ethanol, but not of sucrose.	Ethanol	102-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	42-48
22915106-6	2012	Here, we show that endogenous GluA1 is rapidly inserted at the synaptic plasma membrane of rat hippocampal neurons immediately after stimulation with elevated glycine, a treatment known to induce LTP.	Glycine	159-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
22334120-8	2012	Nevertheless, the CORT-treated rats tended to have more yohimbine-induced impulsive responses at low doses on this task, which was not found to be due to increased pCREB in the lOFC, but could be related to a higher expression/activity of the AMPA receptor subunit GluR1.	Yohimbine	56-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	265-270
22449381-2	2012	Previous studies using animal models show that repeated administration of l-DOPA results in alterations of some signaling molecules, including DeltaFosB, phospho-DARPP32 and phosoho-GluA1 (also referred to as GluR1 or GluR-A) AMPA receptor subunits.	Levodopa	74-80	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	209-214
22449381-2	2012	Previous studies using animal models show that repeated administration of l-DOPA results in alterations of some signaling molecules, including DeltaFosB, phospho-DARPP32 and phosoho-GluA1 (also referred to as GluR1 or GluR-A) AMPA receptor subunits.	Levodopa	74-80	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-224
22449381-8	2012	In agreement with the behavioral analysis, 7-nitroindazole reduced the l-DOPA-induced increases in DeltaFosB, phospho-DARPP32 and phospho-GluA1 AMPA receptor subunit levels in the striatum of 6-hydroxydopamine-lesioned rats.	7-nitroindazole	43-58	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	138-143
22449381-8	2012	In agreement with the behavioral analysis, 7-nitroindazole reduced the l-DOPA-induced increases in DeltaFosB, phospho-DARPP32 and phospho-GluA1 AMPA receptor subunit levels in the striatum of 6-hydroxydopamine-lesioned rats.	Levodopa	71-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	138-143
22302822-0	2012	JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1.	Calcium	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	35-40
22243518-9	2012	In marked contrast, carrageenan induced-trafficking of the GluA1 receptor subunit increased equivalently in both treatment groups.	Carrageenan	20-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
23100433-6	2012	LTP is mediated by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic administration of ethanol, as well as cycles of excessive ethanol consumption and withdrawal, produced a long-lasting increase in synaptic localization of the GluR1 and GluR2 subunits of AMPARs in the DMS.	Ethanol	133-140	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	274-279
23100433-6	2012	LTP is mediated by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic administration of ethanol, as well as cycles of excessive ethanol consumption and withdrawal, produced a long-lasting increase in synaptic localization of the GluR1 and GluR2 subunits of AMPARs in the DMS.	Ethanol	133-140	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	302-308
23100433-6	2012	LTP is mediated by the insertion of AMPAR subunits into the synaptic membrane, and we found that repeated systemic administration of ethanol, as well as cycles of excessive ethanol consumption and withdrawal, produced a long-lasting increase in synaptic localization of the GluR1 and GluR2 subunits of AMPARs in the DMS.	Ethanol	173-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	274-279
22882295-4	2012	In the NAc from the stress plus cocaine group we observed a decrease in the phosphorylation of two ABPs, cofilin and cortactin, and an increase in the PSD size and the surface expression of GluR1, consistent with a more highly branched actin cytoskeleton.	Cocaine	32-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	190-195
22882295-9	2012	Furthermore, by regulating GluR1 expression in the NAc, elevated actin cycling contributes to the expression of cross-sensitization between stress and cocaine, while stress-induced changes in the Pfc were not associated with cross-sensitization.	Cocaine	151-158	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-32
22487868-8	2012	However, after combination therapy with diazepam and mild hypothermia for 8h, the expression of GluR1 was decreased and GluR2 was increased relative to the levels of diazepam alone treated juveniles.	Diazepam	40-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
22449381-2	2012	Previous studies using animal models show that repeated administration of l-DOPA results in alterations of some signaling molecules, including DeltaFosB, phospho-DARPP32 and phosoho-GluA1 (also referred to as GluR1 or GluR-A) AMPA receptor subunits.	Levodopa	74-80	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	182-187
21876464-0	2011	P-chlorophenylalanine increases glutamate receptor 1 transcription in rat amygdala.	Fenclonine	0-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-52
23185117-0	2012	Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats.	Levodopa	0-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	103-108
23185117-0	2012	Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats.	Benserazide	9-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	103-108
23185117-0	2012	Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats.	Levodopa	42-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	103-108
23185117-0	2012	Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats.	Oxidopamine	123-129	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	103-108
23185117-13	2012	The levels of GluR1 at serine-831 (pGluR1S831) and serine-845 (pGluR1S845) were determined by Western blot.	Serine	23-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	14-19
22119624-6	2012	Repetitive SD enhanced the production of dark neurons, reduced the mean volume of normal neurons, increased the number of apoptotic neurons, and enhanced expression of the NR(2B) subunit of NMDA receptors as well as the GluR1 subunit of AMPA receptors in various regions of the juvenile rat brain.	SD 0006	11-13	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	220-225
22830051-3	2012	After 2 days of withdrawal, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphorylates GluA1 subunits at Ser(831), increasing channel conductance.	Serine	116-119	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
22655064-9	2012	The acute cocaine-induced increases in NMDARs in dSTR of LCRs may help to explain the more ready development of locomotor sensitization and susceptibility to addiction-like behaviors in rats that initially exhibit little or no cocaine-induced activation, whereas the AMPAR increases after repeated cocaine may relate to recruitment of more dorsal striatal circuits and maintenance of the marked cocaine-induced locomotor activation observed in all of the rats.	Cocaine	10-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	267-272
22470488-5	2012	This RAB-dependent GluA1 trafficking requires phosphorylation and activation of phosphoinositol-3-phosphate-5-kinase (PIKfyve) and the generation of PI(3,5)P(2).	pi(3,5)p	149-157	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
22470488-9	2012	Our findings demonstrate for the first time an involvement of PIKfyve and PI(3,5)P(2) in NMDA receptor-triggered synaptic GluA1 trafficking.	pi(3,5)p	74-82	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
21839792-5	2011	Especially in P/FC, FLX had the main effect on GluA2 and GluA4 subunits, reaching a 5-fold increase after the drug washout; RBX mostly affected GluA1 and GluA3, reaching a 4-fold increase at the end of the treatment.	Reboxetine	124-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
21276808-8	2011	Levels of GluA1 phosphorylated at serine 845 (pS845 GluA1) were significantly increased in biotinylated tissue and in an extrasynaptic membrane-enriched fraction.	Serine	34-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	10-15
21276808-8	2011	Levels of GluA1 phosphorylated at serine 845 (pS845 GluA1) were significantly increased in biotinylated tissue and in an extrasynaptic membrane-enriched fraction.	Serine	34-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
21876464-5	2011	Using quantitative reverse transcriptase-polymerase chain reaction, we found that rats treated with P-chlorophenylalanine, an inhibitor of tyrosine-5-hydroxylase, resulted in a 21-fold increase in glutamate receptor 1 (GluR1) mRNA expression in the amygdala.	Fenclonine	100-121	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	197-217
21876464-5	2011	Using quantitative reverse transcriptase-polymerase chain reaction, we found that rats treated with P-chlorophenylalanine, an inhibitor of tyrosine-5-hydroxylase, resulted in a 21-fold increase in glutamate receptor 1 (GluR1) mRNA expression in the amygdala.	Fenclonine	100-121	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	219-224
21746893-4	2011	To block the synaptic delivery of endogenous AMPARs, we expressed a fragment of the GluR1-cytoplasmic tail (the 14-aa GluR1 membrane-proximal region with two serines mutated to phospho-mimicking aspartates: MPR-DD).	Serine	158-165	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
21824141-7	2011	Moreover, our results suggest that copper increases GluA1 subunit levels of the AMPA receptor through the anchorage of AMPA receptors to the plasma membrane as a result of PSD-95 accumulation.	Copper	35-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-57
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	63-77	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
22108330-1	2011	OBJECTIVE: The present study aimed to test whether exposure to benzo(a)pyrene [B(a)P] affects spatial learning and short-term memory by modulating the expression of the Gria1 and Grin2a glutamate receptor subunit genes in the hippocampus.	Benzo(a)pyrene	79-84	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
21425350-6	2011	Brief intake of sucrose increased GluR1 in the PSD, regardless of dietary condition, though the net effect was greater in FR than AL subjects.	Sucrose	16-23	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	34-39
21425350-8	2011	This set of results suggests that in FR subjects, sucrose may have primarily increased delivery of GluR1/GluR2 heteromers to the PSD, while in AL subjects sucrose increased delivery of GluR2-lacking channels.	Sucrose	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
21497621-3	2011	Many intracellular proteins, including alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1 and the cyclic AMP response element-binding protein (CREB), in hippocampus contribute to memory formation.	4-isoxazolepropionic	70-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
21746893-4	2011	To block the synaptic delivery of endogenous AMPARs, we expressed a fragment of the GluR1-cytoplasmic tail (the 14-aa GluR1 membrane-proximal region with two serines mutated to phospho-mimicking aspartates: MPR-DD).	Serine	158-165	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
21746893-4	2011	To block the synaptic delivery of endogenous AMPARs, we expressed a fragment of the GluR1-cytoplasmic tail (the 14-aa GluR1 membrane-proximal region with two serines mutated to phospho-mimicking aspartates: MPR-DD).	Aspartic Acid	195-205	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
21640333-0	2011	Enhanced cocaine-conditioned place preference and associated brain regional levels of BDNF, p-ERK1/2 and p-Ser845-GluA1 in food-restricted rats.	Cocaine	9-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
21640333-8	2011	On the other hand, FR rats, whether injected with cocaine or vehicle, displayed elevated p-ERK1/2 and p-Ser845-GluA1 in dorsal hippocampus.	Cocaine	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
21309958-0	2011	Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration.	Cocaine	117-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-39
21309958-6	2011	In comparison, animals trained to self-administer sucrose displayed a similar increase in ERK, but not GluR(1) (S845) , phosphorylation following reexposure to a sucrose-paired environment three weeks later, indicating that GluR(1) (S845) phosphorylation did not result solely from lever press behavior per se.	Sucrose	50-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	224-231
21309958-8	2011	These results suggest that time-dependent emergence of context-associated GluR(1) (S845) phosphorylation in the nucleus accumbens core may contribute to the persistence of cocaine-seeking behavior, whereas ERK phosphorylation may be a consequence of this behavior.	Cocaine	172-179	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-81
21461922-5	2011	The time course of changes in GluR1 phosphorylation correlated with the time course of changes in motor behavior after withdrawal of chronic levodopa therapy.	Levodopa	141-149	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
21692887-3	2011	The latter could reflect enhancement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) transmission, because AMPARs in the NAc mediate some cocaine-induced behaviors.	Cocaine	167-174	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	136-142
20942997-8	2011	Following re-exposure to a cocaine-paired context, surface expression of the AMPA-type glutamate receptor GluR1 was significantly reduced whereas GluR2 was significantly increased in the dlCPu, independent of Arc antisense ODN infusion.	Cocaine	27-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
21216391-6	2011	Among them, GluA1 and GluA3 are preferentially upregulated in their palmitoylation levels by a systemic injection of cocaine.	Cocaine	117-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	12-17
21539895-0	2011	Differential regulation of AMPA receptor GluA1 phosphorylation at serine 831 and 845 associated with activation of NMDA receptor subpopulations.	Serine	66-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
21539895-2	2011	Accumulating evidence demonstrates that two serine sites, S831 and S845, on the AMPA receptor GluA1 subunit, are phosphorylation-regulated and profoundly involved in NMDA receptor-dependent synaptic plasticity.	Serine	44-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
21539895-5	2011	In this study, we demonstrated transiently increased phosphorylation of GluA1 at S831 and persistently decreased phosphorylation of GluA1 at S845 by bath application of NMDA to hippocampal slices from rats.	N-Methylaspartate	169-173	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
21539895-5	2011	In this study, we demonstrated transiently increased phosphorylation of GluA1 at S831 and persistently decreased phosphorylation of GluA1 at S845 by bath application of NMDA to hippocampal slices from rats.	N-Methylaspartate	169-173	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-137
21439793-8	2011	GluR1 protein was significantly decreased in CCI and PTE groups compared to control (p=0.003, and p=0.001, respectively), and in the PTE group compared to the CCI group (p=0.036).	CCI	45-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
21439793-8	2011	GluR1 protein was significantly decreased in CCI and PTE groups compared to control (p=0.003, and p=0.001, respectively), and in the PTE group compared to the CCI group (p=0.036).	CCI	159-162	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
21461922-8	2011	The results suggest that Ser-845 GluR1 phosphorylation within parvalbumin-positive neurons contributes to the persistence of the motor response alterations produced by chronic intermittent dopaminergic stimulation.	Serine	25-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-38
21613507-2	2011	Here we show that daily intravenous cocaine self-administration, but not passive cocaine administration, induces dynamic upregulation of the AMPA glutamate receptor subunits GluR1 and GluR2 in the ventral tegmental area (VTA) of rats.	Cocaine	36-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
21613507-4	2011	We investigated the functional significance of GluR1 upregulation in the VTA on cocaine self-administration using localized viral-mediated gene transfer.	Cocaine	80-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	47-52
21613507-5	2011	Overexpression of GluR1(WT) in rat VTA primarily infected dopamine neurons (75%) and increased AMPA receptor-mediated membrane rectification in these neurons with AMPA application.	Dopamine	58-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	18-23
21613507-7	2011	In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement.	Cocaine	3-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
21613507-7	2011	In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement.	Cocaine	116-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
21613507-7	2011	In cocaine self-administering animals, overexpression of GluR1(WT) in the VTA markedly increased the motivation for cocaine injections on a progressive ratio schedule of cocaine reinforcement.	Cocaine	116-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
21613507-8	2011	In contrast, overexpression of protein kinase A-resistant GluR1(S845A) in the VTA reduced peak rates of cocaine self-administration on a fixed ratio reinforcement schedule.	Cocaine	104-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
21182898-2	2011	We also measured GluA1 phosphorylated at serine 845 (pS845 GluA1) and serine 831 (pS831 GluA1).	Serine	41-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	17-22
21490976-5	2011	In the current experiments, we build upon this signaling cascade by determining that PGE2 induces phosphorylation of the AMPA receptor subunit, GluR1, which leads to increased AMPA receptor insertion at the membrane.	Dinoprostone	85-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
21490976-6	2011	Treating female pups on the day of birth with PGE2 induced the phosphorylation of GluR1 at the PKA-sensitive site within 2 hours of treatment, an effect that was blocked by co-administration of the PKA/AKAP inhibitor, HT31 with PGE2.	Dinoprostone	46-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
21490976-6	2011	Treating female pups on the day of birth with PGE2 induced the phosphorylation of GluR1 at the PKA-sensitive site within 2 hours of treatment, an effect that was blocked by co-administration of the PKA/AKAP inhibitor, HT31 with PGE2.	Dinoprostone	228-232	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
21490976-7	2011	Brief treatment of mixed neuronal/glial POA cultures with PGE2 or the cAMP/PKA stimulator, forskolin, increased membrane associated GluR1 in both neurons and glia.	Dinoprostone	58-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-137
21490976-7	2011	Brief treatment of mixed neuronal/glial POA cultures with PGE2 or the cAMP/PKA stimulator, forskolin, increased membrane associated GluR1 in both neurons and glia.	Cyclic AMP	70-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-137
21490976-7	2011	Brief treatment of mixed neuronal/glial POA cultures with PGE2 or the cAMP/PKA stimulator, forskolin, increased membrane associated GluR1 in both neurons and glia.	Colforsin	91-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-137
21282008-3	2011	Using patch-clamp recording combined with Ca(2+) imaging and cobalt staining, we found that, under normal conditions, an extrasynaptic pool of AMPARs in rat substantia gelatinosa (SG) neurons of spinal dorsal horn predominantly consists of GluR2-containing Ca(2+)-impermeable receptors.	Cobalt	61-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-149
21175880-5	2011	Repeated morphine treatment decreased surface expression of GluA1 in the medial prefrontal cortex without affecting levels of GluA2.	Morphine	9-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
20963825-7	2010	In the LA of unpaired rats, for which the CS was never associated with the US, GluR1 immunoreactivity decreased 84% at excitatory shaft synapses.	Cesium	42-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	79-84
20953906-0	2011	Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain.	Serine	69-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-0	2011	Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain.	Serine	84-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-1	2011	Previous studies have demonstrated that the enhanced levels of phosphorylated alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are involved in central sensitization of inflammatory pain.	Serine	166-172	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	148-153
20953906-1	2011	Previous studies have demonstrated that the enhanced levels of phosphorylated alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are involved in central sensitization of inflammatory pain.	Serine	166-169	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	148-153
20953906-1	2011	Previous studies have demonstrated that the enhanced levels of phosphorylated alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are involved in central sensitization of inflammatory pain.	Serine	198-204	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	148-153
20953906-1	2011	Previous studies have demonstrated that the enhanced levels of phosphorylated alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are involved in central sensitization of inflammatory pain.	Serine	185-188	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	148-153
20953906-5	2011	Meanwhile, the expression of pGluR1-Ser-845 and GluR1 in ipsilateral spinal cord dorsal horn remained unchanged.	Serine	36-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	69-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	69-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	273-278
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	84-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	69-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	69-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	273-278
20953906-8	2011	These results indicate that the phosphorylation of GluR1 subunits at Serine-831 and Serine-845 sites might be differentially regulated following surgical procedures and support a neurobiological mechanism of post-operative pain involved in phosphorylation of AMPA subunits GluR1-Ser-831, but not pGluR1-Ser-845.	Serine	84-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
20953906-9	2011	Our study suggests that the therapeutic targeting the phosphorylation regulation of AMPA receptor GluR1 subunit at Serine-831 site would be potentially significant for treating postoperative pain.	Serine	115-121	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-103
21966506-6	2011	We also analyzed the effects of stimulation (KCl and glutamate) and inhibition (APV/TTX) on rat mature neuronal cultures (DIV26): stimulation with KCl led to an overall down-regulation of GluR1 and GluR3 AMPA receptor subunits and an up-regulation of the GluR2 subunit.	Potassium Chloride	147-150	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	188-193
21966506-7	2011	Similarly, glutamate treatment induced a significant down-regulation of GluR1 together with an up-regulation of GluR2.	Glutamic Acid	11-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
21966506-8	2011	In contrast, the chronic blockade of neuronal activity that resulted from APV/TTX treatment up-regulated GluR1 and GluR3 with a parallel down-regulation of GluR2 and GluR4.	Tetrodotoxin	78-81	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
21821968-10	2011	Furthermore, nefiracetam-induced LTP enhancement was closely associated with calcium/calmodulin-dependent protein kinase II (CaMKII) activation with concomitant increase in phosphorylation of AMPA-type glutamate receptor subunit 1 (GluA1) (Ser-831) as a postsynaptic CaMKII substrate.	nefiracetam	13-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	232-237
20600170-9	2010	In the ventral tegmental area, cocaine self-administration elevated glutamatergic receptor subunits NR1 and GluR1 and scaffolding protein PSD95, but not GABA(A)beta, protein levels.	Cocaine	31-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
20853509-1	2010	Benzodiazepine withdrawal-anxiety is associated with enhanced alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)-mediated glutamatergic transmission in rat hippocampal CA1 synapses due to enhanced synaptic insertion and phosphorylation of GluA1 homomers.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	262-267
20445501-10	2010	Synaptic insertion and subsequent CaMKII alpha-mediated Ser(831) phosphorylation of GluA1 homomers contribute to benzodiazepine withdrawal-induced AMPAR potentiation and may represent an important hippocampal pathway mediating both drug-induced and activity-dependent plasticity.	Benzodiazepines	113-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
20554014-9	2010	Further, pre-administration of BBG inhibited increased expression of the microglial marker Iba-1, phosphorylated p38 (p-p38), interleukin 1beta (IL-1beta) and GluR1 following TSS.	bbg	31-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	159-164
20574537-3	2010	Further, we show that rats given intra-LA infusion of either the NR2B-selective antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor Rp-8-Br-PET-cGMPS exhibit significant decreases in training-induced expression of GluR1, synaptophysin, and synapsin immunoreactivity in the LA, while those rats infused with the PKG activator 8-Br-cGMP exhibit a significant increase in these proteins in the LA.	ifenprodil	91-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
20445501-1	2010	Benzodiazepine withdrawal anxiety is associated with potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal neurons attributable to increased synaptic incorporation of GluA1-containing AMPARs.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	237-242
20445501-1	2010	Benzodiazepine withdrawal anxiety is associated with potentiation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal neurons attributable to increased synaptic incorporation of GluA1-containing AMPARs.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	254-260
20445501-8	2010	Both GluA1 expression levels and CaMKII alpha-mediated GluA1 Ser(831) phosphorylation were increased in PSD-subfractions from 2-day FZP-withdrawn rats.	Serine	61-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
20445501-10	2010	Synaptic insertion and subsequent CaMKII alpha-mediated Ser(831) phosphorylation of GluA1 homomers contribute to benzodiazepine withdrawal-induced AMPAR potentiation and may represent an important hippocampal pathway mediating both drug-induced and activity-dependent plasticity.	Serine	56-59	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
20574537-3	2010	Further, we show that rats given intra-LA infusion of either the NR2B-selective antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor Rp-8-Br-PET-cGMPS exhibit significant decreases in training-induced expression of GluR1, synaptophysin, and synapsin immunoreactivity in the LA, while those rats infused with the PKG activator 8-Br-cGMP exhibit a significant increase in these proteins in the LA.	Cyclic GMP	160-165	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
20574537-3	2010	Further, we show that rats given intra-LA infusion of either the NR2B-selective antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor Rp-8-Br-PET-cGMPS exhibit significant decreases in training-induced expression of GluR1, synaptophysin, and synapsin immunoreactivity in the LA, while those rats infused with the PKG activator 8-Br-cGMP exhibit a significant increase in these proteins in the LA.	8-br	151-155	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
20574537-5	2010	Finally, we show that intra-LA infusions of the ROCK inhibitor Y-27632 or the CaMKII inhibitor KN-93 impair training-induced expression of GluR1, synapsin, and synaptophysin in the LA.	Y 27632	63-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
20574537-5	2010	Finally, we show that intra-LA infusions of the ROCK inhibitor Y-27632 or the CaMKII inhibitor KN-93 impair training-induced expression of GluR1, synapsin, and synaptophysin in the LA.	KN 93	95-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
20074623-8	2010	Consistent with increased CaMKII autophosphorylation, AMPA-type glutamate receptor subunit 1 (GluR1) (Ser-831) phosphorylation as a CaMKII postsynaptic substrate significantly increased after 10 or 50 min of treatment, whereas synapsin I (Ser-603) phosphorylation as a presynaptic substrate increased at 10 min in the hippocampal CA1 region.	Serine	102-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
20074623-8	2010	Consistent with increased CaMKII autophosphorylation, AMPA-type glutamate receptor subunit 1 (GluR1) (Ser-831) phosphorylation as a CaMKII postsynaptic substrate significantly increased after 10 or 50 min of treatment, whereas synapsin I (Ser-603) phosphorylation as a presynaptic substrate increased at 10 min in the hippocampal CA1 region.	Serine	239-242	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
19629758-0	2010	Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation.	Cocaine	38-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
19913087-8	2010	GluR1 subunit expression was markedly decreased at 48 h after one or two exposures to 200 microM glutamate (by 44.57+/-3.6%, 45.07+/-3.69%) whereas GluR2 subunit expression was reduced by a lesser amount (25.7 57+/-3.8%).	Glutamic Acid	97-106	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
19629758-5	2010	Under both paradigms, established cocaine sensitization under non-silenced conditions was associated with enhanced PSD-95 and synapsin I protein expression as well as enhanced Ser(845) phosphorylation of the GluR1 subunit on withdrawal day.	Cocaine	34-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	208-213
19629758-5	2010	Under both paradigms, established cocaine sensitization under non-silenced conditions was associated with enhanced PSD-95 and synapsin I protein expression as well as enhanced Ser(845) phosphorylation of the GluR1 subunit on withdrawal day.	Serine	176-179	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	208-213
19647050-4	2009	Our results showed that stimulation of D1 receptor by the specific agonist SKF38393 (10 microM) in PFC and hippocampal slices significantly increased the phosphorylation state of NR1ser897 and NR2Bser1303 subunits of NMDA receptor and of the GLUR1 (ser831 and ser845) subunit of AMPA receptor, as well as of ERK1/2, but not of DARPP-32.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	75-83	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	242-247
20858955-5	2010	Ibuprofen prevents LTP impairment by Abeta by restoring guanylate cyclase activation and increase in cGMP and, subsequently, activation of protein kinase G, phosphorylation of GluR1 in Ser845 and synaptic expression of AMPA receptors.	Ibuprofen	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	176-181
19482045-1	2009	1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho) (1 microM) enhanced long-term depression (LTD), a synaptic plasticity relevant to learning and memory, in the CA1 region of rat hippocampal slices, where expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluR1 on the plasma membrane was decreased.	1-palmitoyl-2-oleoylphosphatidylcholine	0-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	314-319
19931598-3	2010	Systemically administered SKF-82958, or brief ingestion of a 10% sucrose solution, increased NAc GluR1 phosphorylation on Ser845, but not Ser831, with a greater effect in FR than AL rats.	Sucrose	65-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
19761793-8	2009	We used this approach as an example for applications to quantify the expression of GluR1 and GluR2 subunit mRNAs of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in the hippocampus of untreated rats, and after intraperitoneal application of the organo-arsenic compound dimethyl arsenic acid.	-isoxazolepropionic acid	152-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
19761793-8	2009	We used this approach as an example for applications to quantify the expression of GluR1 and GluR2 subunit mRNAs of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in the hippocampus of untreated rats, and after intraperitoneal application of the organo-arsenic compound dimethyl arsenic acid.	organo-arsenic	276-290	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
19761793-8	2009	We used this approach as an example for applications to quantify the expression of GluR1 and GluR2 subunit mRNAs of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in the hippocampus of untreated rats, and after intraperitoneal application of the organo-arsenic compound dimethyl arsenic acid.	Cacodylic Acid	300-321	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
19482045-1	2009	1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho) (1 microM) enhanced long-term depression (LTD), a synaptic plasticity relevant to learning and memory, in the CA1 region of rat hippocampal slices, where expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluR1 on the plasma membrane was decreased.	pophtcho	50-58	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	314-319
19812341-5	2009	Biochemical assays of isolated mPFC tissue from postnatal rats further showed that cocaine exposure in utero caused a marked reduction in the surface expression of GABA(A) receptor subunits alpha1, beta2, and beta3, but had no effect on glutamate receptor subunit GluR1.	Cocaine	83-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	264-269
19591855-5	2009	Long-term exposure to 20 nM TBT decreased the mRNA expression of glutamate receptors NR1, NR2A, GluR1 and GluR2, and increased that of NR2B, GluR3 and GluR4.	tributyltin	28-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
19559763-2	2009	In this study, we investigated the regulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor GluR1 subunit phosphorylation by cocaine exposure in the rat dorsal striatum in vivo.	bucide	73-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
19559763-2	2009	In this study, we investigated the regulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor GluR1 subunit phosphorylation by cocaine exposure in the rat dorsal striatum in vivo.	Cocaine	155-162	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
18841347-5	2009	Reward-potentiating effects of the D-1 DA receptor agonist, SKF-82958, AMPAR antagonist, DNXQ, and polyamine GluR1 antagonist, 1-na spermine, were assessed using the curve-shift method of self-stimulation testing.	Polyamines	99-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
19559763-3	2009	We found that acute cocaine challenge followed by 6 days of repeated systemic injections of cocaine (20 mg/kg once daily) enhanced the sensitivity of the GluR1 subunit in its phosphorylation at serine 831 (Ser831) in the dorsal striatum.	Cocaine	20-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
19559763-3	2009	We found that acute cocaine challenge followed by 6 days of repeated systemic injections of cocaine (20 mg/kg once daily) enhanced the sensitivity of the GluR1 subunit in its phosphorylation at serine 831 (Ser831) in the dorsal striatum.	Cocaine	92-99	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
19559763-3	2009	We found that acute cocaine challenge followed by 6 days of repeated systemic injections of cocaine (20 mg/kg once daily) enhanced the sensitivity of the GluR1 subunit in its phosphorylation at serine 831 (Ser831) in the dorsal striatum.	Serine	194-200	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
19559763-6	2009	In addition, inhibition of protein phosphatase 1/2A or calcineurin increased GluR1-Ser831 phosphorylation in the dorsal striatum of normal rats, whereas inhibition of these phosphatases did not further enhance the Ser831 phosphorylation in rats pretreated with 7 daily injections of cocaine.	Cocaine	283-290	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-82
19559763-7	2009	These data suggest that the phosphorylation of AMPA receptor GluR1 subunits at Ser831 is subject to upregulation by acute and repeated cocaine administration.	Cocaine	135-142	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	61-66
19564213-6	2009	Increased phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit GluR1 (p-Ser831) was seen in DOM-potentiated slices.	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic	29-81	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	111-116
19674091-6	2009	GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.	Tetrodotoxin	57-69	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
19674091-9	2009	Repeated dopamine (DA) treatment, which leads to upregulation of surface GluR1 and GluR2, occluded activity blockade-induced synaptic scaling.	Dopamine	9-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
19674091-9	2009	Repeated dopamine (DA) treatment, which leads to upregulation of surface GluR1 and GluR2, occluded activity blockade-induced synaptic scaling.	Dopamine	19-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
19258522-0	2009	Activation of group I metabotropic glutamate receptors increases serine phosphorylation of GluR1 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the rat dorsal striatum.	Serine	65-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
19368820-9	2009	These data suggest that extinguished cocaine seeking is associated with changes in GluR1 and NMDAR1 expression and subcellular distribution that are region-specific and consist of both a reversal of cocaine-induced adaptations and emergent extinction-related alterations that include receptor subunit redistribution and may involve alterations in scaffolding proteins.	Cocaine	37-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
19368820-9	2009	These data suggest that extinguished cocaine seeking is associated with changes in GluR1 and NMDAR1 expression and subcellular distribution that are region-specific and consist of both a reversal of cocaine-induced adaptations and emergent extinction-related alterations that include receptor subunit redistribution and may involve alterations in scaffolding proteins.	Cocaine	199-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
18977602-5	2009	We found that fluoxetine treatment increased expression of phosphosynapsin, PSD-95 and synaptic GluR1 (but not total GluR1) in the hippocampus of ovariectomized but not sham rats.	Fluoxetine	14-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	96-101
18977602-5	2009	We found that fluoxetine treatment increased expression of phosphosynapsin, PSD-95 and synaptic GluR1 (but not total GluR1) in the hippocampus of ovariectomized but not sham rats.	Fluoxetine	14-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	117-122
19627999-0	2009	Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.	3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	25-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	115-120
19383086-6	2009	Changes were also observed in the phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate subunit GluR-1(Ser831) which, however, relied on the acute stress exposure and were independent of gestational stress.	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	57-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-131
19141314-5	2009	The cholinergic agonist carbachol also depressed GluR1-3 mRNA levels, suggesting that AMPAR down-regulation is a global response to extended periods of elevated neuronal activity.	Carbachol	24-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
19084907-5	2009	Region-specific increases in cyclic AMP-dependent GluR(1) (S845) phosphorylation were found in the nucleus accumbens shell, basolateral amygdala, hippocampal CA1 and CA3 subregions, and premotor cortex from 12 to 24 h of spontaneous withdrawal, and there were no changes in prefrontal cortex, nucleus accumbens core or caudate-putamen.	Cyclic AMP	29-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-57
18640148-9	2008	In cocaine sensitized rats GluR1 protein was increased in the mPFC on PND37 but not in other ages.	Cocaine	3-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-32
19077125-0	2009	Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses.	Morphine	14-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
19077125-3	2009	In this study, changes in expression and phosphorylation levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor subunits (GluR1, GluR2) in the hippocampus were investigated in rats showing a conditioned response (CR) to an opiate-paired environment as well as in animals in which this conditioned behavior was extinguished.	3-(1,2-oxazol-3-yl)propanoic acid	100-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	160-165
19077125-6	2009	Results showed that morphine-dependent CRs did not alter expression or redistribution of GluR1 or GluR2; however, the unpaired administration of morphine resulted in an increase in the phosphorylation of the GluR1 subunit at extrasynaptic sites.	Morphine	145-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	208-213
19077125-8	2009	Therefore we propose that, within the synapse, the phosphorylation of the GluR1 subunit at the PSD may be a key mechanism in the extinction of opiate-associated CRs.	Opiate Alkaloids	143-149	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
18657555-8	2009	Tianeptine, but not imipramine, increased the phosphorylation of Ser831-GluA1.	tianeptine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
18657555-12	2009	Tianeptine, but not imipramine, increased the phosphorylation of Ser831-GluA1, indicating a potential effect on AMPA receptor phosphorylation being involved in the reversal of LTP.	tianeptine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
18924138-0	2008	Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.	Benzodiazepines	91-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	24-29
18924138-8	2008	Taken together with recent functional data from our laboratory, the current study suggests that the enhanced glutamatergic strength at CA1 neuron synapses during benzodiazepine withdrawal is mediated by increased incorporation of GluR1-containing AMPARs.	Benzodiazepines	162-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	230-235
18924138-8	2008	Taken together with recent functional data from our laboratory, the current study suggests that the enhanced glutamatergic strength at CA1 neuron synapses during benzodiazepine withdrawal is mediated by increased incorporation of GluR1-containing AMPARs.	Benzodiazepines	162-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	247-253
18368037-2	2008	Here, we investigate the mechanism of DCS effect by measuring internalized GluR1 and GluR2 using cell-surface biotinylation techniques.	Cycloserine	38-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	75-80
18368037-4	2008	Low-frequency stimulation (LFS) when applied in the presence of DCS induced GluR1 and GluR2 internalization in the amygdala slices.	Cycloserine	64-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	76-81
18368037-7	2008	In the in vivo experiments, DCS-induced reduction of fear-potentiated startle and reversal of conditioning-induced increase in surface expression of GluR1 were blocked by proteasome inhibitors.	Cycloserine	28-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	149-154
18640148-11	2008	However, cocaine pretreatment during adolescence induced a transient increase of GluR1 in the mPFC only when animals were challenged in the same age.	Cocaine	9-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
18294632-0	2008	Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens.	Morphine	26-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
18706480-6	2008	We found a significant increase in synaptosomal membrane GluR1 expression in magnesium-free (MGF) medium-treated neurons at each time point detected (p<0.05), while GluR2 expression increased at 7DIV, and declined at 17DIV and 21DIV respectively (p<0.05).	Magnesium	77-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
18706480-6	2008	We found a significant increase in synaptosomal membrane GluR1 expression in magnesium-free (MGF) medium-treated neurons at each time point detected (p<0.05), while GluR2 expression increased at 7DIV, and declined at 17DIV and 21DIV respectively (p<0.05).	MGF	93-96	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
18815253-0	2008	Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration.	Morphine	144-152	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
18815253-3	2008	Indeed, chronic morphine administration is known to increase AMPA receptor glutamate receptor 1 (GluR1) subunit in the VTA.	Morphine	16-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	75-95
18815253-3	2008	Indeed, chronic morphine administration is known to increase AMPA receptor glutamate receptor 1 (GluR1) subunit in the VTA.	Morphine	16-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
18815253-6	2008	Acute morphine administration produced a significant increase in GluR1 immunogold particles at the plasma membrane and postsynaptic densities in both TH- and non-TH-containing dendrites in the parabrachial VTA, a region that contains mainly prefrontal-cortical-projecting dopaminergic neurons involved in motivation and drug-seeking behavior.	Morphine	6-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
18815253-7	2008	Chronic morphine administration maintained the increased synaptic GluR1 labeling in the parabrachial VTA, but also increased the number of GluR1-labeled synapses and TH immunoreactivity in dendrites of the paranigral VTA where substantially more dopaminergic neurons project to limbic structures implicated in locomotor activation and reward.	Morphine	8-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	66-71
18815253-7	2008	Chronic morphine administration maintained the increased synaptic GluR1 labeling in the parabrachial VTA, but also increased the number of GluR1-labeled synapses and TH immunoreactivity in dendrites of the paranigral VTA where substantially more dopaminergic neurons project to limbic structures implicated in locomotor activation and reward.	Morphine	8-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18815253-8	2008	These results demonstrate a region- and dose-dependent redistribution of GluR1-containing AMPA receptors, which is consistent with acute morphine activation of cortical-projecting VTA neurons and chronic morphine activation of limbic-projecting VTA neurons.	Morphine	137-145	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
18815253-8	2008	These results demonstrate a region- and dose-dependent redistribution of GluR1-containing AMPA receptors, which is consistent with acute morphine activation of cortical-projecting VTA neurons and chronic morphine activation of limbic-projecting VTA neurons.	Morphine	204-212	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
17433502-6	2008	The results reveal that the NR1 and GluR1 subunits decline with age in AL, but not CR rats.	Aluminum	71-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	36-41
18639534-7	2008	These results suggest that excitatory afferent signals from the peripheral vestibular receptors, resulting from acute hypotension, release glutamate into postsynaptic neurons in the vestibular nuclei and the excitatory signals are transmitted through the GluR1 subunit of the AMPA receptors and the NR2B subunits of the NMDA receptors in the vestibular system.	Glutamic Acid	139-148	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	255-260
18486119-0	2008	Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior.	Cocaine	95-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-55
18486119-0	2008	Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior.	Cocaine	127-134	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-55
18486119-4	2008	We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior.	Cocaine	241-248	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	35-40
18486119-4	2008	We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior.	Cocaine	241-248	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-55
18486119-6	2008	Administration of antisense oligonucleotides (AS) directed against GluR1 subunit mRNA into the core and shell disrupted AMPA- and cocaine-primed reinstatement--with the most pronounced effects seen in the nucleus accumbens shell.	Oligonucleotides	28-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	67-72
18344555-0	2008	Modulation of AMPA receptor GluR1 subunit phosphorylation in neurons by the intravenous anaesthetic propofol.	Propofol	100-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
18344555-4	2008	anaesthetic agent propofol on the phosphorylation of AMPA receptor GluR1 subunits in cultured neurons.	Propofol	18-26	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	67-72
18344555-5	2008	METHODS: The effect of propofol on phosphorylation of GluR1 subunits at serine 831 and 845 was assayed in cultured rat striatal and cortical neurons by western blot with phospho- and site-specific antibodies.	Propofol	23-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
18344555-5	2008	METHODS: The effect of propofol on phosphorylation of GluR1 subunits at serine 831 and 845 was assayed in cultured rat striatal and cortical neurons by western blot with phospho- and site-specific antibodies.	Serine	72-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
18344555-6	2008	RESULTS: Propofol consistently elevated phosphorylation of GluR1 subunits at the C-terminal serine 845 site in both striatal and cortical neurons.	Propofol	9-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
18344555-6	2008	RESULTS: Propofol consistently elevated phosphorylation of GluR1 subunits at the C-terminal serine 845 site in both striatal and cortical neurons.	Serine	92-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
18344555-9	2008	In contrast to serine 845, phosphorylation of GluR1 at serine 831 was not altered by propofol in striatal and cortical neurons.	Serine	55-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
18344555-10	2008	Total GluR1 abundance remained unchanged in response to propofol incubation.	Propofol	56-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	6-11
18344555-11	2008	CONCLUSIONS: These data indicate that propofol possesses the ability to upregulate AMPA receptor GluR1 subunit phosphorylation at a specific serine 845 site in neurons and provide evidence supporting the AMPA receptor as a molecular target for general anaesthetics.	Propofol	38-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
18344555-11	2008	CONCLUSIONS: These data indicate that propofol possesses the ability to upregulate AMPA receptor GluR1 subunit phosphorylation at a specific serine 845 site in neurons and provide evidence supporting the AMPA receptor as a molecular target for general anaesthetics.	Serine	141-147	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-102
18294632-3	2008	Immunogold electron microscopy was used to quantify the surface expression of the AMPA GluR1 subunit in dendritic profiles of neurons in the Acb in response to intermittent 14-day non-contingent injections of escalating doses of morphine, a model that parallels opioid self-administration.	acb	141-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
18294632-3	2008	Immunogold electron microscopy was used to quantify the surface expression of the AMPA GluR1 subunit in dendritic profiles of neurons in the Acb in response to intermittent 14-day non-contingent injections of escalating doses of morphine, a model that parallels opioid self-administration.	Morphine	229-237	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
18294632-4	2008	To determine if changes in GluR1 trafficking occurred in neurons potentially sensitive to dopamine-induced D1R activation, immunoperoxidase labeling of D1R was combined with immunogold labeling of GluR1.	Dopamine	90-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-32
18294632-6	2008	We provide the first report that chronic morphine administration is associated with a receptor-phenotypic decrease in surface trafficking of GluR1 in Acb subregions.	Morphine	41-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	141-146
18294632-7	2008	When compared to saline injected animals, morphine produced a decrease in plasma membrane GluR1 labeling in medium- and large-sized D1R expressing dendritic profiles in the Acb shell.	Morphine	42-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
18294632-7	2008	When compared to saline injected animals, morphine produced a decrease in plasma membrane GluR1 labeling in medium- and large-sized D1R expressing dendritic profiles in the Acb shell.	acb	173-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
18294632-8	2008	In contrast, in the Acb core, surface GluR1 was decreased in small-sized dendrites that did not express the dopamine receptor.	acb	20-23	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
18294632-9	2008	These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core.	Morphine	82-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18294632-9	2008	These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core.	Glutamic Acid	179-188	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18294632-9	2008	These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core.	Dopamine	193-201	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18294632-9	2008	These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core.	acb	232-235	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18294632-9	2008	These results indicate that chronic intermittent injection of escalating doses of morphine is accompanied by ultrastructural plasticity of GluR1 in neurons that are responsive to glutamate and dopamine-induced D1R activation in the Acb shell, and neurons capable of responding to glutamate but not D1R receptor stimulation in the Acb core.	Glutamic Acid	280-289	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18065236-7	2008	Hippocampal neuronal transfection with truncated GluR1 resulted in a significant reduction in apoptotic neuronal death triggered by toxic concentrations of glutamate.	Glutamic Acid	156-165	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
18289517-3	2008	By method of Western blot, expression of GluR1 (the main subunit of the AMPA receptor) and its phosphorylated forms at serine 845 (pGluR1-Ser845) and at serine 831 (pGluR1-Ser831) in the spinal dorsal horn was observed.	Serine	119-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
18289517-3	2008	By method of Western blot, expression of GluR1 (the main subunit of the AMPA receptor) and its phosphorylated forms at serine 845 (pGluR1-Ser845) and at serine 831 (pGluR1-Ser831) in the spinal dorsal horn was observed.	Serine	153-159	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	41-46
18278040-4	2008	Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	142-162
18278040-4	2008	Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	164-169
18278040-4	2008	Cocaine reinstatement is associated with D1-like dopamine receptor-dependent increases in accumbens shell CaMKII phosphorylated on Thr286 and glutamate receptor 1 (GluR1) phosphorylated on Ser831 (a known CaMKII phosphorylation site), in addition to increases in cell-surface expression of GluR1-containing AMPA receptors in the shell.	Cocaine	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	290-295
18278040-5	2008	Consistent with these findings, cocaine reinstatement is attenuated by intra-shell administration of AAV10-GluR1-C99, a vector that impairs the transport of GluR1-containing AMPA receptors.	Cocaine	32-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
18278040-5	2008	Consistent with these findings, cocaine reinstatement is attenuated by intra-shell administration of AAV10-GluR1-C99, a vector that impairs the transport of GluR1-containing AMPA receptors.	Cocaine	32-39	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	157-162
18160635-6	2007	NMDA or AMPA receptor antagonists blocked this effect, and it was not observed in pure VTA cultures, suggesting that DA agonists acted on D1 receptors on PFC neurons, altering their excitatory transmission onto VTA DA neurons and, thus, influencing AMPARs.	N-Methylaspartate	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	249-255
18031714-7	2008	Following the development of hypertension, GluR1 spine and puncta counts were significantly greater in DOCA-salt rats than controls.	Desoxycorticosterone Acetate	103-107	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
18031714-7	2008	Following the development of hypertension, GluR1 spine and puncta counts were significantly greater in DOCA-salt rats than controls.	Salts	108-112	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
18031714-9	2008	The density of GluR1 puncta in the NTS was significantly reduced by hydralazine treatment in the SHR model.	Hydralazine	68-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
18160635-7	2007	To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001).	Dopamine	47-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18160635-7	2007	To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001).	Cocaine	78-85	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18160635-7	2007	To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001).	Dopamine	118-120	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18160635-7	2007	To mimic the longer elevation in extracellular DA levels produced by systemic cocaine, cocultures were incubated with DA for 1 h. Synaptic GluR1 was increased 24 h later, reminiscent of the increased AMPA/NMDA ratio at excitatory synapses onto VTA DA neurons 24 h after cocaine injection (Ungless et al., 2001).	Cocaine	270-277	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
18042863-8	2007	Lumbar spinal cords were extracted 1 h after incision or sham treatment to measure phosphorylated CaMKIIalpha and alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid GLUR1-831 in Western immunoblots.	alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid	114-171	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	172-177
18239782-0	2007	Combined blockade of alpha3beta4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures.	Kainic Acid	109-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
17651730-13	2007	However, methamphetamine increased levels of GluR1 and its phosphorylation state in the prefrontal cortex (PFC), and these increases were attenuated by deprenyl.	Methamphetamine	9-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	45-50
17680995-4	2007	Moreover, in sensitized rats acute cocaine administration modified phosphorylation levels of Thr75- and Thr34-DARPP-32, GluR1, and NR1 subunits in the nucleus accumbens only at a dose double the efficacious dose in control rats.	Cocaine	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
17680995-6	2007	Furthermore, in sensitized rats the acute administration of 6-methyl-2-(phenylethynyl)-pyridine, a mGluR5 antagonist, reinstated the phosphorylation levels of Thr75- and Thr34-DARPP-32, GluR1, and NR1 to control values, and a subsequent cocaine challenge did not elicit a sensitized response.	6-methyl-2-(phenylethynyl)pyridine	60-95	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	186-191
17901379-10	2007	However, SHRs displayed an increase in phosphorylated form of GluR1 at Ser-831 (P<0.05), as well as in calcium/calmodulin kinase-II alpha (P<0.002).	Serine	71-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	62-67
17884024-4	2007	In the present study we mutated the equivalent lysine in the rat AMPA receptor subunit GluR1 flip to alanine (K445A) and assessed changes in nucleotide affinity from the displacement of [(3)H]fluorowillardiine.	Lysine	47-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
17884024-4	2007	In the present study we mutated the equivalent lysine in the rat AMPA receptor subunit GluR1 flip to alanine (K445A) and assessed changes in nucleotide affinity from the displacement of [(3)H]fluorowillardiine.	Alanine	101-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
17898233-4	2007	Glutamate receptor 1 (GluR1) and GluR2 surface/intracellular (S/I) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion).	Cocaine	178-185	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-20
17898233-4	2007	Glutamate receptor 1 (GluR1) and GluR2 surface/intracellular (S/I) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion).	Cocaine	178-185	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-27
17898233-4	2007	Glutamate receptor 1 (GluR1) and GluR2 surface/intracellular (S/I) ratios were increased after 14 d of withdrawal in sensitized rats but were decreased 24 h after challenge with cocaine (which elicited a sensitized locomotor response) or saline (which elicited conditioned locomotion).	Sodium Chloride	238-244	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-20
17898233-7	2007	JNK phosphorylation also increased after withdrawal, but after cocaine challenge, it was inversely related to GluR1 and GluR2 S/I ratios.	Cocaine	63-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	110-115
17898233-11	2007	Although JNK results were complex, JNK and p38 may be involved in AMPAR internalization after cocaine or saline challenge, respectively.	Cocaine	94-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	66-71
17898233-11	2007	Although JNK results were complex, JNK and p38 may be involved in AMPAR internalization after cocaine or saline challenge, respectively.	Sodium Chloride	105-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	66-71
17510319-0	2007	Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons.	Benzodiazepines	0-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	85-90
17510319-3	2007	Whole-cell recordings of rat hippocampal CA1 neurons, either acutely dissociated or in hippocampal slices, revealed that AMPAR function was enhanced up to 50% during flurazepam (FZP) withdrawal, without changes in whole-cell channel kinetic properties.	Flurazepam	166-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-126
17510319-4	2007	Agonist-elicited AMPA currents showed a negative shift in rectification in the presence of spermine, suggesting augmented membrane incorporation of glutamate receptor (GluR) 2-lacking AMPARs.	Spermine	91-99	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-190
18239782-1	2007	Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5-3.0 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.7-4 times.	IEM 1754	27-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
18239782-1	2007	Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5-3.0 mg/kg decreased the incidence of kainate-induced tonic-clonic seizures and mortality rate by 2.7-4 times.	Kainic Acid	134-141	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
17439498-5	2007	Chronic cocaine produced region- and substrate-specific tolerance to cAMP-dependent protein phosphorylation, including GluR1(S845) phosphorylation in striatal and amygdala subregions and NR1(S897) phosphorylation in the CA1 subregion of the hippocampus.	Cocaine	8-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
17439498-5	2007	Chronic cocaine produced region- and substrate-specific tolerance to cAMP-dependent protein phosphorylation, including GluR1(S845) phosphorylation in striatal and amygdala subregions and NR1(S897) phosphorylation in the CA1 subregion of the hippocampus.	Cyclic AMP	69-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
17439498-6	2007	Tolerance also developed to cAMP-independent GluR1(S831) phosphorylation in the prefrontal cortex.	Cyclic AMP	28-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	45-50
16766131-5	2006	Moreover, phosphorylation of Ca2+/calmodulin-dependent protein kinase II at thr286 and glutamate receptor 1 at ser831 was increased 30 min post-high-frequency stimulation and blocked by N-methyl-D-aspartate receptor antagonists (AP-5 and MK-801).	2-amino-5-phosphopentanoic acid	229-233	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-107
17167071-6	2007	The functional activity of PKC immediately after status epilepticus was assessed by evaluating phosphorylation of the AMPA receptor subunit GluR1 (Ser-831), a substrate for PKC.	Serine	147-150	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
17194442-4	2007	Paroxetine increased the interaction of GluR1 with Rab4A, and desipramine markedly increased the interaction of GluR1 with SAP97.	Paroxetine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	40-45
17194442-4	2007	Paroxetine increased the interaction of GluR1 with Rab4A, and desipramine markedly increased the interaction of GluR1 with SAP97.	Desipramine	62-73	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
17194442-5	2007	Paroxetine, but not desipramine, also increased membrane levels of CaMKII, autophosphorylated CaMKII and GluR1 phosphorylated at the CaMKII site.	Paroxetine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
16794574-0	2007	Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors.	Cocaine	12-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
17113046-15	2007	Moreover, 8-OH-DPAT plus levodopa significantly reduced hyperphosphorylation of GluR1 at serine 845, which was closely associated with levodopa-induced motor complications.	8-Hydroxy-2-(di-n-propylamino)tetralin	10-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
17113046-15	2007	Moreover, 8-OH-DPAT plus levodopa significantly reduced hyperphosphorylation of GluR1 at serine 845, which was closely associated with levodopa-induced motor complications.	Levodopa	25-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
17113046-15	2007	Moreover, 8-OH-DPAT plus levodopa significantly reduced hyperphosphorylation of GluR1 at serine 845, which was closely associated with levodopa-induced motor complications.	Serine	89-95	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
17113046-15	2007	Moreover, 8-OH-DPAT plus levodopa significantly reduced hyperphosphorylation of GluR1 at serine 845, which was closely associated with levodopa-induced motor complications.	Levodopa	135-143	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
16839606-11	2006	The expression of NR2B (NMDA receptor) and GluR1 (AMPA receptor) subunits was significantly reduced in the TCDD-exposed F1 generation animals compared to vehicle controls.	Polychlorinated Dibenzodioxins	107-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
16903873-8	2006	NMDA treatment decreased postsynaptic GluR1, GluR2 and GluR6/7 but increased presynaptic levels of these subunits.	N-Methylaspartate	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
16936133-7	2006	RESULTS: In primary cultures, high glucose significantly decreased the protein content of GluR1 and GluR6/7 subunits and increased the protein content of GluR2 and KA2 subunits.	Glucose	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
17360914-7	2007	Western blot analysis of postsynaptic density fractions after NMDA-induced LTD revealed that the LTD was attributable to dephosphorylation of the AMPA receptor subunit glutamate receptor 1 (GluR1) at serine 845, without a change in total GluR content.	N-Methylaspartate	62-66	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	190-195
17360914-7	2007	Western blot analysis of postsynaptic density fractions after NMDA-induced LTD revealed that the LTD was attributable to dephosphorylation of the AMPA receptor subunit glutamate receptor 1 (GluR1) at serine 845, without a change in total GluR content.	Serine	200-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	190-195
17053970-0	2006	Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats.	Oxidopamine	89-106	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
17053970-0	2006	Changes in subcellular distribution and phosphorylation of GluR1 in lesioned striatum of 6-hydroxydopamine-lesioned and l-dopa-treated rats.	Levodopa	120-126	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
17053970-3	2006	To determine whether serine phosphorylation of GluR1 subunit by activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) contributes to the process, we examined the effects of unilateral nigrostriatal depletion with 6-hydroxydopamine and subsequent L: -dopa treatment on motor responses and phosphorylation states.	Serine	21-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	47-52
17053970-3	2006	To determine whether serine phosphorylation of GluR1 subunit by activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) contributes to the process, we examined the effects of unilateral nigrostriatal depletion with 6-hydroxydopamine and subsequent L: -dopa treatment on motor responses and phosphorylation states.	Oxidopamine	228-245	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	47-52
17053970-3	2006	To determine whether serine phosphorylation of GluR1 subunit by activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) contributes to the process, we examined the effects of unilateral nigrostriatal depletion with 6-hydroxydopamine and subsequent L: -dopa treatment on motor responses and phosphorylation states.	Levodopa	261-269	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	47-52
17053970-5	2006	We found a significant reduction in the abundance of both phosphorylated GluR1 at serine-831 site (pGluR1S831) and GluR1 in the cell plasma membrane of lesioned striatum.	Serine	82-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	73-78
17053970-5	2006	We found a significant reduction in the abundance of both phosphorylated GluR1 at serine-831 site (pGluR1S831) and GluR1 in the cell plasma membrane of lesioned striatum.	Serine	82-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
17053970-6	2006	Chronic treatment of lesioned rats with L: -dopa markedly upregulated the phosphorylation of GluR1 in lesioned striatum with a concomitant normalization of the plasma membrane GluR1 abundance, which lasted at least 1 day after withdrawal of chronic L: -dopa treatment.	Levodopa	40-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	93-98
17053970-6	2006	Chronic treatment of lesioned rats with L: -dopa markedly upregulated the phosphorylation of GluR1 in lesioned striatum with a concomitant normalization of the plasma membrane GluR1 abundance, which lasted at least 1 day after withdrawal of chronic L: -dopa treatment.	Levodopa	40-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	176-181
17053970-6	2006	Chronic treatment of lesioned rats with L: -dopa markedly upregulated the phosphorylation of GluR1 in lesioned striatum with a concomitant normalization of the plasma membrane GluR1 abundance, which lasted at least 1 day after withdrawal of chronic L: -dopa treatment.	Levodopa	249-257	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	93-98
16766131-5	2006	Moreover, phosphorylation of Ca2+/calmodulin-dependent protein kinase II at thr286 and glutamate receptor 1 at ser831 was increased 30 min post-high-frequency stimulation and blocked by N-methyl-D-aspartate receptor antagonists (AP-5 and MK-801).	Dizocilpine Maleate	238-244	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-107
16092949-0	2005	Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures.	Topiramate	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	63-68
16687214-3	2006	We found that repeated administration of morphine significantly elevated aAbs levels to MDOR and to the AMPA GluR1 subunit, but not to the NMDA NR2 subunit.	Morphine	41-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	pyridine	139-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	4-9
16529871-9	2006	GluR1 expression was increased after nucleus basalis lesion, but this increase was prevented with MK-801.	Dizocilpine Maleate	98-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
16775132-3	2006	In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).	Dopamine	170-178	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	143-148
16775132-3	2006	In the NAc, the function of the transcription factor cAMP response element binding protein (CREB) and AMPA glutamate receptor subunit, type 1 (GluR1) can be regulated by dopamine (DA) D1 receptor-mediated phosphorylation (P-CREB, P-GluR1).	Dopamine	170-178	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	232-237
16620883-5	2006	In biochemical studies performed on rat hippocampus after the retention tests, we found that learning increased the membrane levels of AMPA receptor GluR1 and GluR2/3 subunits, as well as the phosphorylated forms of GluR1, effects that were abolished by NBQX administration before the training session.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	254-258	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	216-221
16620883-6	2006	Pretreatment with WAY-100635 counteracted the NBQX effects and restored the initial learning-specific increase in Ca2+/calmodulin-dependent protein kinase II (CaMKII) function and the later increase in GluR2/3 and phosphorylated GluR1 surface expression.	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	18-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	229-234
16620883-6	2006	Pretreatment with WAY-100635 counteracted the NBQX effects and restored the initial learning-specific increase in Ca2+/calmodulin-dependent protein kinase II (CaMKII) function and the later increase in GluR2/3 and phosphorylated GluR1 surface expression.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	46-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	229-234
16256076-12	2006	One potential limitation of [3H]FW is a large preference for subunits GluR1 and GluR2 (KD 4-10 nM) over GluR3 and GluR4 (160-600 nM) which implies that tests with brain membranes preferentially reveal drug effects produced at the former two subunits.	Tritium	29-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	70-75
16420457-7	2006	Finally, BEL also prevented the potentiation of fEPSPs elicited by brief exposure to 50 microM N-methyl-d-aspartate, as well as the associated up-regulation of alpha-amino-3-hydroxy-5-methylisoxazole-propionate (AMPA) receptor GluR1 subunit levels and the increase of (3)H-AMPA binding in crude synaptic fractions.	6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one	9-12	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	227-232
16451215-0	2006	Expression of AMPA receptor subunits (GluR1-GluR4) in gonadotrophin-releasing hormone neurones of young and middle-aged persistently oestrous rats during the steroid-induced luteinising hormone surge.	Steroids	158-165	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
16219906-2	2006	Here, by labeling surface receptors with biotin or using membrane fractionation approaches, we report that fear conditioning resulted in an increase in surface expression of GluR1 subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the amygdala, whereas total GluR1 mRNA and protein levels were unchanged.	Biotin	41-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	174-179
16219906-5	2006	CS-alone trials applied 24 h before training attenuated fear-potentiated startle and prevented conditioning-induced increase in surface expression of GluR1.	Cesium	0-2	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	150-155
16099093-3	2005	Incubation of rat brain sections with 3 microM BEL enhanced phosphorylation on the serine (Ser) 831 residue of the AMPA receptor GluR1 subunit in synaptosomal P2 fractions, whereas AACOCF3 at the same concentration resulted in increased phosphorylation on residues Ser880/891 of GluR2/3 subunits.	Serine	83-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
16099093-3	2005	Incubation of rat brain sections with 3 microM BEL enhanced phosphorylation on the serine (Ser) 831 residue of the AMPA receptor GluR1 subunit in synaptosomal P2 fractions, whereas AACOCF3 at the same concentration resulted in increased phosphorylation on residues Ser880/891 of GluR2/3 subunits.	Serine	91-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
16207873-4	2005	Surface/intracellular (S/I) ratios for glutamate receptor 1 (GluR1) and GluR2/3 subunits were increased 21 d after the last injection in cocaine-sensitized rats but not rats that failed to sensitize, and the magnitude of the S/I ratio for cocaine-sensitized rats was positively correlated with the magnitude of behavioral sensitization.	Cocaine	137-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-59
16207873-4	2005	Surface/intracellular (S/I) ratios for glutamate receptor 1 (GluR1) and GluR2/3 subunits were increased 21 d after the last injection in cocaine-sensitized rats but not rats that failed to sensitize, and the magnitude of the S/I ratio for cocaine-sensitized rats was positively correlated with the magnitude of behavioral sensitization.	Cocaine	137-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	61-66
16037950-0	2005	Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine.	Morphine	138-146	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
16037950-4	2005	High-resolution immunogold electron microscopic immunocytochemistry was used to compare surface and intracellular labeling of the calcium sensitive AMPA GluR1 receptor subunit in the basolateral (BLA) and central (CeA) nuclei of the amygdala in rats self-administering escalating doses of morphine or saline.	Calcium	130-137	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	153-158
16037950-4	2005	High-resolution immunogold electron microscopic immunocytochemistry was used to compare surface and intracellular labeling of the calcium sensitive AMPA GluR1 receptor subunit in the basolateral (BLA) and central (CeA) nuclei of the amygdala in rats self-administering escalating doses of morphine or saline.	cea	214-217	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	153-158
16037950-4	2005	High-resolution immunogold electron microscopic immunocytochemistry was used to compare surface and intracellular labeling of the calcium sensitive AMPA GluR1 receptor subunit in the basolateral (BLA) and central (CeA) nuclei of the amygdala in rats self-administering escalating doses of morphine or saline.	Morphine	289-297	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	153-158
16037950-4	2005	High-resolution immunogold electron microscopic immunocytochemistry was used to compare surface and intracellular labeling of the calcium sensitive AMPA GluR1 receptor subunit in the basolateral (BLA) and central (CeA) nuclei of the amygdala in rats self-administering escalating doses of morphine or saline.	Sodium Chloride	301-307	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	153-158
16037950-5	2005	Morphine self-administration was associated with regionally diverse effects on dendritic GluR1 targeting in the BLA and CeA.	Morphine	0-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	89-94
16037950-6	2005	In the BLA of morphine self-administering animals, there was a significant increase in the proportion of immunogold particles for GluR1 on the plasma membrane of dendrites, particularly in association with extrasynaptic sites, which was most prominent in large (2-4 microm) profiles.	Morphine	14-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	130-135
16037950-9	2005	These results indicate that GluR1 targeting is a dynamic process that can be differentially affected in distinct amygdala regions in response to chronic self-administration of morphine.	Morphine	176-184	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
16092936-8	2005	In addition, administration of WAY-100635 potentiated the learning-specific increase in the hippocampus of phospho-CaMKII, Ca(2+)-independent CaMKII activity, as well as the phosphorylation of either the CaMKII or the PKA site on the AMPA receptor GluR1 subunit.	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	31-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	248-253
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	pyridine	139-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-91
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	Glutamic Acid	151-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	4-9
16631211-3	2006	The GluR1-4 affinities of 3 were similar to 1, however, its 31-fold selectivity for GluR1/2 over GluR3/4 is the highest yet observed among azine-based glutamate analogues.	Glutamic Acid	151-160	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-91
16775132-4	2006	However, the roles of D1 receptors, CREB, and GluR1 in morphine dependence are not well understood.	Morphine	55-63	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	46-51
16775132-5	2006	Here, we show that somatic signs of naloxone-precipitated withdrawal were associated with increased P-CREB, but not P-GluR1, in the NAc of morphine-dependent rats.	Naloxone	36-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	118-123
16775132-7	2006	Surprisingly, SKF 82958 increased P-GluR1, but not P-CREB, in the NAc, and naloxone reduced SKF 82958-mediated P-GluR1 induction specifically in morphine-dependent rats.	Naloxone	75-83	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	113-118
16775132-7	2006	Surprisingly, SKF 82958 increased P-GluR1, but not P-CREB, in the NAc, and naloxone reduced SKF 82958-mediated P-GluR1 induction specifically in morphine-dependent rats.	Morphine	145-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	113-118
16775132-10	2006	These data raise the possibility that the rewarding effects of SKF 82958 in morphine-dependent rats involve increased P-GluR1 in the NAc, although the involvement of other brain regions cannot be ruled out.	Morphine	76-84	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
16267106-5	2006	Application of 1-naphthylacetyl spermine (NAS), a selective antagonist of Ca(2+)-permeable AMPARs (CP-AMPARs), inhibited AMPAR-mediated currents in subsets of interneurons and principal cells in cultures and slices.	1-naphthylacetylspermine	15-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
16267106-5	2006	Application of 1-naphthylacetyl spermine (NAS), a selective antagonist of Ca(2+)-permeable AMPARs (CP-AMPARs), inhibited AMPAR-mediated currents in subsets of interneurons and principal cells in cultures and slices.	1-naphthylacetylspermine	42-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
16267106-5	2006	Application of 1-naphthylacetyl spermine (NAS), a selective antagonist of Ca(2+)-permeable AMPARs (CP-AMPARs), inhibited AMPAR-mediated currents in subsets of interneurons and principal cells in cultures and slices.	cp-ampars	99-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
16326431-0	2005	Increases in [(3)H]-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor binding and mRNA expression of AMPA-sensitive glutamate receptor A (GluR-A) subunits in rats withdrawn from butorphanol.	Butorphanol	201-212	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-159
16326431-0	2005	Increases in [(3)H]-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor binding and mRNA expression of AMPA-sensitive glutamate receptor A (GluR-A) subunits in rats withdrawn from butorphanol.	Butorphanol	201-212	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	161-167
16326431-9	2005	These findings suggest that increases in expression of mRNA for the GluR-A receptor and in the binding of AMPA to its receptor may play an important role during withdrawal from butorphanol dependence.	Butorphanol	177-188	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-74
16219028-4	2005	Protein kinase A (PKA)-specific phosphorylation of Ser845 in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR1 was used to assess endogenous functional activity of PKA.	hydroxide ion	79-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	142-147
16219028-4	2005	Protein kinase A (PKA)-specific phosphorylation of Ser845 in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR1 was used to assess endogenous functional activity of PKA.	bucide	89-104	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	142-147
16219028-4	2005	Protein kinase A (PKA)-specific phosphorylation of Ser845 in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR1 was used to assess endogenous functional activity of PKA.	Propionates	107-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	142-147
15893611-4	2005	The levels of mRNAs coding for AMPA receptor subunits, GluR1, GluR2, and GluR3, were significantly increased in all layers (laminae I-V) of the dorsal horn in diabetic (STZ-injected) rats compared to control (vehicle-injected) rats.	Streptozocin	169-172	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
16029214-10	2005	However, phosphorylation of the CaMKII-PP1 substrate, Ser831 in the glutamate receptor GluR1 subunit, was increased only after sustained (9-20 months) dopamine depletion.	Dopamine	151-159	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
16029214-11	2005	Interaction of ageing-related changes in PP1 with the dopamine depletion-induced changes in CaMKIIalpha may account for enhanced GluR1 phosphorylation only after long-term dopamine depletion.	Dopamine	54-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
16029214-11	2005	Interaction of ageing-related changes in PP1 with the dopamine depletion-induced changes in CaMKIIalpha may account for enhanced GluR1 phosphorylation only after long-term dopamine depletion.	Dopamine	172-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-134
16182449-5	2005	Step-down inhibitory avoidance training increased the quantity of GluR1 and GluR2/3 AMPA receptor subunits and the phosphorylation of GluR1 at Ser-831 but not at Ser-845 in CA1 postsynaptic densities.	Serine	143-146	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	134-139
15548228-0	2004	A single high dose of cocaine induces behavioural sensitization and modifies mRNA encoding GluR1 and GAP-43 in rats.	Cocaine	22-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
15548228-3	2004	The present study investigated whether in Sprague-Dawley rats a single, behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth-associated protein 43 (GAP-43), an important protein in mediating experience-dependent plasticity and synaptic reorganization, and of glutamate receptor 1 (GluR1), a subunit of AMPA glutamate receptors, a protein that is up-regulated with repeated cocaine.	Cocaine	104-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	307-327
15276247-2	2004	Western blots indicated a rapid and prolonged (30 min and 7 days post-inflammation) increase in phosphoserine 831 GluR1 protein levels in the RVM.	Phosphoserine	96-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
15548228-3	2004	The present study investigated whether in Sprague-Dawley rats a single, behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth-associated protein 43 (GAP-43), an important protein in mediating experience-dependent plasticity and synaptic reorganization, and of glutamate receptor 1 (GluR1), a subunit of AMPA glutamate receptors, a protein that is up-regulated with repeated cocaine.	Cocaine	104-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	329-334
15276247-3	2004	The upregulated GluR1 phosphorylation was blocked by pretreatment, but not by post-treatment, with the local anesthetic, lidocaine, at the site of inflammation.	Lidocaine	121-130	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	16-21
15276247-4	2004	The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.	Phosphoserine	20-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
15276247-4	2004	The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.	chelerythrine	80-93	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
15276247-4	2004	The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.	KN 93	122-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
15276247-4	2004	The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.	Dizocilpine Maleate	194-200	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
15276247-4	2004	The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.	apv	205-208	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
15255976-10	2004	The effect of glutamate was also partially blocked by the group 1 metabotropic glutamate receptor antagonist N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC; 50 microM), while the group 1 agonist 3,5-dihydroxyphenylglycine (DHPG; 50 microM) stimulated GluR1 internalization.	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide	109-169	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	272-277
15255976-10	2004	The effect of glutamate was also partially blocked by the group 1 metabotropic glutamate receptor antagonist N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC; 50 microM), while the group 1 agonist 3,5-dihydroxyphenylglycine (DHPG; 50 microM) stimulated GluR1 internalization.	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide	171-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	272-277
15255976-5	2004	The rate of GluR1 internalization was increased by glutamate (50 microM) within 5 min of its addition.	Glutamic Acid	51-60	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	12-17
18634600-6	2004	This reduction in synaptic GluR1 by lithium and VPA is due to attenuated phosphorylation of GluR1 at a specific PKA site (residue 845 of GluR1), which is crucial for AMPA receptor insertion.	Lithium	36-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-32
15255976-6	2004	Glutamate-induced GluR1 internalization was partially blocked by either an AMPA receptor antagonist (CNQX; 20 microM) or an N-methyl-D-aspartate (NMDA) receptor antagonist (APV; 50 microM).	Glutamic Acid	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	18-23
15255976-6	2004	Glutamate-induced GluR1 internalization was partially blocked by either an AMPA receptor antagonist (CNQX; 20 microM) or an N-methyl-D-aspartate (NMDA) receptor antagonist (APV; 50 microM).	6-Cyano-7-nitroquinoxaline-2,3-dione	101-105	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	18-23
15255976-6	2004	Glutamate-induced GluR1 internalization was partially blocked by either an AMPA receptor antagonist (CNQX; 20 microM) or an N-methyl-D-aspartate (NMDA) receptor antagonist (APV; 50 microM).	apv	173-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	18-23
15255976-7	2004	Both NMDA (50 microM) and AMPA (50 microM) increased GluR1 internalization in a Ca(2+)-dependent manner.	N-Methylaspartate	5-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	53-58
15255976-10	2004	The effect of glutamate was also partially blocked by the group 1 metabotropic glutamate receptor antagonist N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC; 50 microM), while the group 1 agonist 3,5-dihydroxyphenylglycine (DHPG; 50 microM) stimulated GluR1 internalization.	Glutamic Acid	14-23	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	272-277
15223297-8	2004	These results suggest that activation of NR2B subunit containing NMDA receptors contributes to both the development and maintenance of levodopa-induced motor response alterations, through a mechanism that involves an increase in GluR1 phosphorylation in striatal spiny neurons.	Levodopa	135-143	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	229-234
15287884-7	2004	In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.	alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate	224-276	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	198-203
15287884-8	2004	The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.	Morphine	145-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-35
18634600-5	2004	Two clinically effective, structurally dissimilar, antimanic agents, lithium and valproate (VPA), down-regulate synaptic expression of AMPA receptor subunit GluR1 in hippocampus in chronically treated rats.	Lithium	69-76	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	157-162
18634600-5	2004	Two clinically effective, structurally dissimilar, antimanic agents, lithium and valproate (VPA), down-regulate synaptic expression of AMPA receptor subunit GluR1 in hippocampus in chronically treated rats.	Valproic Acid	81-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	157-162
18634600-6	2004	This reduction in synaptic GluR1 by lithium and VPA is due to attenuated phosphorylation of GluR1 at a specific PKA site (residue 845 of GluR1), which is crucial for AMPA receptor insertion.	Lithium	36-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
18634600-5	2004	Two clinically effective, structurally dissimilar, antimanic agents, lithium and valproate (VPA), down-regulate synaptic expression of AMPA receptor subunit GluR1 in hippocampus in chronically treated rats.	Valproic Acid	92-95	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	157-162
18634600-6	2004	This reduction in synaptic GluR1 by lithium and VPA is due to attenuated phosphorylation of GluR1 at a specific PKA site (residue 845 of GluR1), which is crucial for AMPA receptor insertion.	Lithium	36-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
18634600-7	2004	By contrast,imipramine, which can provoke mania, increases synaptic expression of GluR1 in the hippocampus in vivo.	Imipramine	12-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
15269270-3	2004	The present studies were undertaken to determine whether two clinically effective, but structurally highly dissimilar, antimanic agents lithium and valproate regulate synaptic expression of AMPA receptor subunit glutamate receptor 1 (GluR1).	Lithium	136-143	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	234-239
15269270-3	2004	The present studies were undertaken to determine whether two clinically effective, but structurally highly dissimilar, antimanic agents lithium and valproate regulate synaptic expression of AMPA receptor subunit glutamate receptor 1 (GluR1).	Valproic Acid	148-157	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	234-239
15269270-4	2004	Chronic (but not acute) treatment of rats with therapeutically relevant concentrations of lithium or valproate reduced hippocampal synaptosomal GluR1 levels.	Lithium	90-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
15269270-4	2004	Chronic (but not acute) treatment of rats with therapeutically relevant concentrations of lithium or valproate reduced hippocampal synaptosomal GluR1 levels.	Valproic Acid	101-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	144-149
15269270-5	2004	The reduction in synaptic GluR1 by lithium and valproate was attributable to a reduction of surface GluR1 distribution onto the neuronal membrane as demonstrated by three independent assays in cultured hippocampal neurons.	Lithium	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	26-31
15269270-5	2004	The reduction in synaptic GluR1 by lithium and valproate was attributable to a reduction of surface GluR1 distribution onto the neuronal membrane as demonstrated by three independent assays in cultured hippocampal neurons.	Lithium	35-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
15269270-5	2004	The reduction in synaptic GluR1 by lithium and valproate was attributable to a reduction of surface GluR1 distribution onto the neuronal membrane as demonstrated by three independent assays in cultured hippocampal neurons.	Valproic Acid	47-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	26-31
15269270-5	2004	The reduction in synaptic GluR1 by lithium and valproate was attributable to a reduction of surface GluR1 distribution onto the neuronal membrane as demonstrated by three independent assays in cultured hippocampal neurons.	Valproic Acid	47-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	adenosine-3',5'-cyclic phosphorothioate	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	104-109
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	adenosine-3',5'-cyclic phosphorothioate	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-172
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	adenosine-3',5'-cyclic phosphorothioate	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	Lithium	65-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-172
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	Lithium	65-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
15269270-7	2004	Sp-cAMP treatment reversed the attenuation of phosphorylation by lithium and valproate and also brought GluR1 back to the surface, suggesting that phosphorylation of GluR1p845 is involved in the mechanism of GluR1 surface attenuation.	Valproic Acid	77-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
15269270-8	2004	In addition, GluR1p845 phosphorylation also was attenuated in hippocampus from lithium- or valproate-treated animals in vivo.	Lithium	79-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-19
15269270-8	2004	In addition, GluR1p845 phosphorylation also was attenuated in hippocampus from lithium- or valproate-treated animals in vivo.	Valproic Acid	91-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-19
15269270-9	2004	In contrast, imipramine, an antidepressant that can trigger manic episodes, increased synaptic expression of GluR1 in hippocampus in vivo.	Imipramine	13-23	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	109-114
14770185-2	2004	Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT(2) and FlAsH-EDT(2) staining.	edt	91-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
15139014-5	2004	Quantitative RT-PCR revealed that GluR1-3 mainly occurred in the flip forms, which agreed with the stronger potentiation of receptor currents by CTZ vs. PEPA.	cyclothiazide	145-148	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	34-39
15009682-8	2004	A maximally effective concentration of SpcAMPS (10 microm) occluded the effect of SKF 81297 (1 microm) on GluR1 externalization.	SK and F 81297	82-91	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
14770185-2	2004	Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT(2) and FlAsH-EDT(2) staining.	edt	108-111	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	54-59
14684466-6	2003	The AMPA receptor subunit GluR1 expression in hippocampal synaptosomes was significantly reduced by both chronic lithium and valproate.	Lithium	113-120	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	26-31
15233572-0	2004	Down-regulation of the AMPA glutamate receptor subunits GluR1 and GluR2/3 in the rat cerebellum following pre- and perinatal delta9-tetrahydrocannabinol exposure.	Dronabinol	125-152	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	224-231	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	224-231	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	224-231	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	224-231	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
15233572-1	2004	This paper reports the effects of pre- and perinatal exposure to delta9-tetrahydrocannabinol (THC) on expression levels of specific AMPA glutamate receptor subunits (GluR1 and GluR2/3) in the cerebellum of male and female rats.	Dronabinol	65-92	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
15233572-1	2004	This paper reports the effects of pre- and perinatal exposure to delta9-tetrahydrocannabinol (THC) on expression levels of specific AMPA glutamate receptor subunits (GluR1 and GluR2/3) in the cerebellum of male and female rats.	Dronabinol	94-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
15233572-3	2004	Expression of the GluR1 and GluR2/3 subunits of AMPA glutamate receptors was analyzed by immunohistochemistry in THC-exposed rats at three postnatal ages: PD20 (still exposed to THC) to study the direct effect of drug exposure, and PD30 and PD70 (10 and 50 days following THC withdrawal) to analyze the long-term effects of prenatal exposure.	Dronabinol	113-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	18-23
15233572-4	2004	Compared to controls, pre- and perinatal THC exposure decreased the immunoreactivity levels of the GluR1 subunit in Bergmann glial cells, as well as levels of the GluR2/3 subunit in Purkinje neurons at PD20.	Dronabinol	41-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	107-114	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	14-34
14675153-6	2004	Expression of glutamate receptor 1 (GluR1) mRNA was decreased in both P10 SE rats and identically handled, lithium-injected littermate controls compared to naive animals, and GluR1 protein levels were significantly lower in lithium-controls than in naive rats, suggesting an effect of either the handling or the lithium on GluR1 expression.	Lithium	107-114	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	36-41
14687884-1	2004	The phosphorylation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors subunit GluR1 at Ser831 has been implicated in the regulation of AMPA receptors channel.	-hydroxy-5-methylisoxazole-4-propionic	36-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
15183518-6	2004	Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.	Morphine	136-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-66
15183518-9	2004	Specifically, GABA-A alpha1 subunit, GRIA1 subunit and PSD-95 mRNAs were decreased in the shell but increased in the core following morphine administration.	Morphine	132-140	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
14663022-5	2003	In hemiparkinsonian rats, KW6002 reversed the intermittent L-dopa treatment-induced, protein kinase A-mediated hyperphosphorylation of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid receptor GluR1 S845 residues and the concomitant shortening in motor response duration.	Levodopa	59-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	212-217
12892651-0	2003	Gene expression of glutamate receptors GluR1 and NR1 is differentially modulated in striatal neurons in rats after 6-hydroxydopamine lesion.	Oxidopamine	115-132	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
12892651-7	2003	The present results indicate that there is an opposite trend in modulation in the gene expressions of GluR1 and NR1 in the neostriatum of 6-OHDA-lesioned rats after dopamine denervation.	Oxidopamine	138-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	102-107
12892651-7	2003	The present results indicate that there is an opposite trend in modulation in the gene expressions of GluR1 and NR1 in the neostriatum of 6-OHDA-lesioned rats after dopamine denervation.	Dopamine	165-173	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	102-107
14684466-6	2003	The AMPA receptor subunit GluR1 expression in hippocampal synaptosomes was significantly reduced by both chronic lithium and valproate.	Valproic Acid	125-134	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	26-31
14684466-7	2003	Overall, these studies show that AMPA receptor subunit GluR1 is a common target for two structurally highly dissimilar, but highly efficacious, mood stabilizers, lithium and valproate.	Lithium	162-169	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
14684466-7	2003	Overall, these studies show that AMPA receptor subunit GluR1 is a common target for two structurally highly dissimilar, but highly efficacious, mood stabilizers, lithium and valproate.	Valproic Acid	174-183	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
12787079-6	2003	In the accumbens of cocaine-trained rats, GluR1 and NMDAR1 levels were increased on days 1 and 90, while GluR2 levels were increased on days 1 and 30, but not day 90; PKA activity levels were increased on days 1 and 30, but not day 90, while AC activity, TH and cdk5 levels were unaltered.	Cocaine	20-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	42-47
14637099-3	2003	In rats, KW-6002 reversed the shortened motor response produced by chronic levodopa treatment while reducing levodopa-induced hyperphosphorylation at S845 residues on AMPA receptor GluR1 subunits.	istradefylline	9-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	181-186
14637099-3	2003	In rats, KW-6002 reversed the shortened motor response produced by chronic levodopa treatment while reducing levodopa-induced hyperphosphorylation at S845 residues on AMPA receptor GluR1 subunits.	Levodopa	109-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	181-186
14559367-1	2003	The present project was designed to investigate the role of protein kinase A (PKA) and protein kinase C (PKC) in the regulation of phosphorylation of the GluR1 subunits of AMPA receptors in the spinal cord of rats after capsaicin injection.	Capsaicin	220-229	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
14559367-2	2003	We found that after capsaicin injection, a significant upregulation of phosphorylated GluR1 both at Ser(831) and Ser(845) was detected on the side ipsilateral to the injection.	Capsaicin	20-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
14559367-2	2003	We found that after capsaicin injection, a significant upregulation of phosphorylated GluR1 both at Ser(831) and Ser(845) was detected on the side ipsilateral to the injection.	Serine	100-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
14559367-2	2003	We found that after capsaicin injection, a significant upregulation of phosphorylated GluR1 both at Ser(831) and Ser(845) was detected on the side ipsilateral to the injection.	Serine	113-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
14511343-5	2003	A panel of immunoblots for other proteins in the excitatory postsynaptic density revealed that AS1, but not AS2 reduced the level of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunit GluR1 protein.	(N(omega)-L-arginino)succinic acid	95-98	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
14511343-5	2003	A panel of immunoblots for other proteins in the excitatory postsynaptic density revealed that AS1, but not AS2 reduced the level of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunit GluR1 protein.	SCHEMBL4437207	149-193	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
14596864-0	2003	Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin.	Capsaicin	168-177	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-38
12676339-1	2003	We used immunoblot analysis to investigate the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-receptor glutamate receptor-1 (GluR1) and related protein kinases in rat hippocampus on postnatal days (PND) 1-28.	-3-hydroxy-5-methyl-4-isoxazole proprionic acid	77-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	141-161
12676339-1	2003	We used immunoblot analysis to investigate the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-receptor glutamate receptor-1 (GluR1) and related protein kinases in rat hippocampus on postnatal days (PND) 1-28.	-3-hydroxy-5-methyl-4-isoxazole proprionic acid	77-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	163-168
12676339-3	2003	The proportions of the forms of GluR1 phosphorylated at serines (S) 845 and S831, which were both high at birth, decreased at different rates: phosphorylated S831 decreased rapidly after PND 7, and was almost zero after PND 21, while phosphorylated S845 decreased slowly, and after PND 14 stayed at one third of its PND 1 level.	Serine	56-63	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
12676339-0	2003	Differential phosphorylation at serine sites in glutamate receptor-1 within neonatal rat hippocampus.	Serine	32-38	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	48-68
12507773-2	2003	The expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor 1 (GluR1) greatly impairs the chemotaxis induced by CXCL2 in CXCR2-expressing HEK cells.	amino-3-hydroxy-5-methyl-4-isoxazolepropionate	24-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-103
12507773-2	2003	The expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor 1 (GluR1) greatly impairs the chemotaxis induced by CXCL2 in CXCR2-expressing HEK cells.	amino-3-hydroxy-5-methyl-4-isoxazolepropionate	24-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
14596864-4	2003	Western blots and immunohistochemistry were performed to examine the expression and localization of GluR1 and the phosphorylated forms of GluR1 (phospho-GluR1) at Ser-831 and Ser-845 with specific antibodies.	Serine	163-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	138-143
14596864-6	2003	A significant upregulation of phospho-GluR1 both at Ser-831 and Ser-845 was found by 5 min after capsaicin treatment, and this increase lasted at least 60 min.	Serine	52-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
14596864-6	2003	A significant upregulation of phospho-GluR1 both at Ser-831 and Ser-845 was found by 5 min after capsaicin treatment, and this increase lasted at least 60 min.	Serine	64-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
14596864-6	2003	A significant upregulation of phospho-GluR1 both at Ser-831 and Ser-845 was found by 5 min after capsaicin treatment, and this increase lasted at least 60 min.	Capsaicin	97-106	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
14596864-4	2003	Western blots and immunohistochemistry were performed to examine the expression and localization of GluR1 and the phosphorylated forms of GluR1 (phospho-GluR1) at Ser-831 and Ser-845 with specific antibodies.	Serine	163-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	138-143
12390532-4	2002	Surface GluR1 labeling on processes of medium spiny neurons and interneurons was increased by brief (5-15 min) incubation with a D1 agonist (1 microm SKF 81297).	SK and F 81297	150-159	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	8-13
12527472-2	2002	Here we studied the acute and chronic effect of the antidepressants desipramine and paroxetine, which differentially affect monoamine reuptake, on the expression of the AMPAR subunits GluR1 and GluR2/3, analyzed by Western blot, both in total and in membrane-enriched extracts from rat hippocampus.	Desipramine	68-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
12527472-2	2002	Here we studied the acute and chronic effect of the antidepressants desipramine and paroxetine, which differentially affect monoamine reuptake, on the expression of the AMPAR subunits GluR1 and GluR2/3, analyzed by Western blot, both in total and in membrane-enriched extracts from rat hippocampus.	Paroxetine	84-94	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
12527472-2	2002	Here we studied the acute and chronic effect of the antidepressants desipramine and paroxetine, which differentially affect monoamine reuptake, on the expression of the AMPAR subunits GluR1 and GluR2/3, analyzed by Western blot, both in total and in membrane-enriched extracts from rat hippocampus.	monoamine	124-133	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	184-189
11929637-7	2002	GluR1, GluR2 and GluR3 subunits were present in many sacral preganglionic neurons retrogradely labelled with Ctbeta applied to the pelvic nerve, and in some dorsolateral and dorsomedian motoneurons retrogradely labelled with Ctbeta injected in ischiocavernosus and bulbospongiosus muscles.	ctbeta	109-115	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
12220704-2	2002	In this study, the protein expression levels of several ionotropic glutamate receptor subunits (N-methyl-D-aspartate (NMDA) subunits NR1, NR2A, NR2B, and alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunits GluR1, GluR2, GluR4) were quantified in particulate preparations from rat spinal cord at various ages after birth.	N-Methylaspartate	96-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	237-242
12220704-2	2002	In this study, the protein expression levels of several ionotropic glutamate receptor subunits (N-methyl-D-aspartate (NMDA) subunits NR1, NR2A, NR2B, and alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunits GluR1, GluR2, GluR4) were quantified in particulate preparations from rat spinal cord at various ages after birth.	N-Methylaspartate	118-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	237-242
12070131-6	2002	NEEP21 down-regulation retards recycling of GluR1 to the cell surface after NMDA stimulation of hippocampal neurons.	N-Methylaspartate	76-80	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	44-49
12379442-1	2002	The mRNAs encoding the flip and flop isoforms of the glutamate receptor subunits GluR1 and 2 were detected and quantified by in situ hybridization in the hippocampal formation of rats following acute (6h) or chronic (6h daily for 21 days) restraint stress.	6H	201-203	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-92
12379442-1	2002	The mRNAs encoding the flip and flop isoforms of the glutamate receptor subunits GluR1 and 2 were detected and quantified by in situ hybridization in the hippocampal formation of rats following acute (6h) or chronic (6h daily for 21 days) restraint stress.	6H	217-219	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-92
12161022-3	2002	The affinity of C-terminal-deleted GluR1 for glutamate (Glu) remained stable instead.	Glutamic Acid	45-54	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	35-40
12019337-8	2002	In addition, spinal CaMK II activity enhances phosphorylation of AMPA receptor GluR1 subunits during central sensitization produced by capsaicin injection.	Capsaicin	135-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	79-84
11929637-7	2002	GluR1, GluR2 and GluR3 subunits were present in many sacral preganglionic neurons retrogradely labelled with Ctbeta applied to the pelvic nerve, and in some dorsolateral and dorsomedian motoneurons retrogradely labelled with Ctbeta injected in ischiocavernosus and bulbospongiosus muscles.	ctbeta	225-231	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
11783759-3	2002	Gene expression of the main N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor subunits NMDAR1 and GLUR1, respectively, were investigated by reverse transcription-polymerase chain reaction (RT-PCR).	N-Methylaspartate	28-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
11754364-1	2002	During a developmental study of the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) -type glutamate receptor subunits in rat spinal cord, we observed the existence of cytoplasmic inclusion bodies with positive immunoreactivity to glutamate receptor subunit 1 (GluR1) but not to other glutamate receptor subunits.	amino-	56-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	256-284
11754364-1	2002	During a developmental study of the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) -type glutamate receptor subunits in rat spinal cord, we observed the existence of cytoplasmic inclusion bodies with positive immunoreactivity to glutamate receptor subunit 1 (GluR1) but not to other glutamate receptor subunits.	amino-	56-62	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	286-291
11754364-1	2002	During a developmental study of the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) -type glutamate receptor subunits in rat spinal cord, we observed the existence of cytoplasmic inclusion bodies with positive immunoreactivity to glutamate receptor subunit 1 (GluR1) but not to other glutamate receptor subunits.	-hydroxy-5-methyl-4-isoxazolepropionate	63-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	256-284
11754364-1	2002	During a developmental study of the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) -type glutamate receptor subunits in rat spinal cord, we observed the existence of cytoplasmic inclusion bodies with positive immunoreactivity to glutamate receptor subunit 1 (GluR1) but not to other glutamate receptor subunits.	-hydroxy-5-methyl-4-isoxazolepropionate	63-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	286-291
11751027-7	2002	GluR1 immunolabeling was further examined in rats killed 16-18 hrs or 24 hrs after a single injection of amphetamine or repeated injections of saline, amphetamine (5 mg/kg x 5 days) or cocaine (20 mg/kg x 7 days).	Amphetamine	105-116	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
11783759-3	2002	Gene expression of the main N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor subunits NMDAR1 and GLUR1, respectively, were investigated by reverse transcription-polymerase chain reaction (RT-PCR).	-hydroxy-5-methyl-isoxazole-4-propionic acid	73-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
11368924-5	2001	Specific inhibitors of Ca(2+)-dependent PLA(2) prevented the decrease of a neuronal marker, GluR1, and increase in cPLA(2) and 4-HNE immunoreactivities in slices treated with kainate.	Kainic Acid	175-182	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	92-97
11801363-7	2002	Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.	Cocaine	46-53	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	104-109
11414791-6	2001	These results suggest that the unedited expression of GluR2 and the reduced ratio of GluR2/GluR1 render NADPH-d(+) neurons highly sensitive to Ca2+-mediated AMPA neurotoxicity.	NADP	104-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
11414791-4	2001	The nested PCR specific for GluR1-GluR4 showed that rat striatal NADPH-d(+) neurons expressed twice as much GluR1 mRNA as NADPH-d(-) neurons did.	NADP	65-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
11414791-4	2001	The nested PCR specific for GluR1-GluR4 showed that rat striatal NADPH-d(+) neurons expressed twice as much GluR1 mRNA as NADPH-d(-) neurons did.	NADP	65-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
11414791-4	2001	The nested PCR specific for GluR1-GluR4 showed that rat striatal NADPH-d(+) neurons expressed twice as much GluR1 mRNA as NADPH-d(-) neurons did.	NADP	122-127	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
11484817-0	2001	Kainate-induced epilepsy alters protein expression of AMPA receptor subunits GluR1, GluR2 and AMPA receptor binding protein in the rat hippocampus.	Kainic Acid	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-82
11329132-4	2001	The results showed that subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate-preferring, kainate-preferring, and NMDA-preferring receptor subunits are distributed widely but heterogeneously and that the GluR1, GluR2, kainate-2, NMDAR1, NMDAR2A, and NMDAR2B subunits are the most abundant in the hypothalamus.	methyl-4-isoxazole	60-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	216-221
11150316-5	2001	NMDA-induced potentiation was associated with increased levels of glutamate receptor 1 (GluR1) and GluR2/3 subunits of AMPA receptors in synaptic membrane preparations, whereas no change was observed in whole homogenates.	N-Methylaspartate	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	66-86
11279267-8	2001	Additionally, cerebellar but not cortical PSDs exhibited significantly lower enrichment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluR1.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	91-147	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
11279267-8	2001	Additionally, cerebellar but not cortical PSDs exhibited significantly lower enrichment of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) GluR1.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	149-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
11150316-5	2001	NMDA-induced potentiation was associated with increased levels of glutamate receptor 1 (GluR1) and GluR2/3 subunits of AMPA receptors in synaptic membrane preparations, whereas no change was observed in whole homogenates.	N-Methylaspartate	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
11150316-6	2001	Both KN-62, an inhibitor of calcium/calmodulin kinase, and calpain inhibitor III, a calpain inhibitor, inhibited NMDA-induced potentiation and changes in GluR1 and GluR2/3 subunits of AMPA receptors.	KN 62	5-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
11150316-6	2001	Both KN-62, an inhibitor of calcium/calmodulin kinase, and calpain inhibitor III, a calpain inhibitor, inhibited NMDA-induced potentiation and changes in GluR1 and GluR2/3 subunits of AMPA receptors.	N-Methylaspartate	113-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
11150316-8	2001	Pretreatment of hippocampal slices with BFA significantly decreased NMDA-induced potentiation and completely prevented an NMDA-induced increase in GluR1 levels in membrane fractions.	Brefeldin A	40-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	147-152
11150316-8	2001	Pretreatment of hippocampal slices with BFA significantly decreased NMDA-induced potentiation and completely prevented an NMDA-induced increase in GluR1 levels in membrane fractions.	N-Methylaspartate	122-126	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	147-152
11682165-3	2001	Therefore, in the present study, we further tested the hypothesis that the calcium-permeable subunit GluR1 of AMPA type GluRs and nNOS are colocalized in neurons of the nucleus tractus solitarii.	Calcium	75-82	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	101-106
10901268-2	2000	To investigate the potency of a novel immunotoxin that is specific for glutamate receptor GluR1, a subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)-type receptor channel, immunolesioning was performed.	-isoxazole-propionate	146-167	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
10936193-2	2000	To receive glutamate signals, pinealocytes express at least three kinds of glutamate receptors: metabotropic receptor types 3 and 5 and an ionotropic receptor, GluR1.	Glutamic Acid	11-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	160-165
11029631-6	2000	As a multifunctional scaffolding protein, SAP97 may organize components of AMPA-related intracellular signalling pathways, including those associated with calcium-permeable homomeric GluR1 channels.	Calcium	155-162	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	183-188
10822164-0	2000	An autoradiographic study of [3H]AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits following morphine withdrawal in the rat brain.	Morphine	148-156	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-119
10869513-6	2000	While aniracetam delayed the decay time of currents through the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, GluR1, -2, -3, expressed in oocytes, nefiracetam or piracetam had no effect on the currents.	aniracetam	6-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
10854273-10	2000	It is possible that GluR1 participates in a signaling cascade that enhances and expands the L-glutamate signal throughout the pineal gland.	Glutamic Acid	92-103	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	20-25
10822164-0	2000	An autoradiographic study of [3H]AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits following morphine withdrawal in the rat brain.	Morphine	148-156	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-127
10629751-1	1999	This is a study of the effect of the unilateral administration of dopamine (DA) in the pars compacta of the substantia nigra (SN) of the rat on striatal glutamate receptor subunit (GluR1, GluR2 and NMDAR1) gene expression determined by in situ hybridization.	Dopamine	66-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	181-186
10684909-1	2000	Repeated administration of morphine increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area (VTA) of the midbrain, an important neural substrate for the rewarding actions of morphine.	Morphine	27-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
10684909-1	2000	Repeated administration of morphine increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area (VTA) of the midbrain, an important neural substrate for the rewarding actions of morphine.	Morphine	215-223	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-65
10684909-2	2000	Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.	Morphine	149-157	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
10684909-2	2000	Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.	Morphine	149-157	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-107
10684909-2	2000	Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.	Morphine	149-157	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	102-107
10684909-2	2000	Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.	Morphine	323-331	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	91-96
10684909-2	2000	Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.	Morphine	323-331	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	98-107
10684909-3	2000	We now report that in rats given HSV-GluR1 directly into the VTA, morphine is most rewarding when maximal transgene expression is in the rostral VTA, whereas morphine is aversive when maximal transgene expression is in the caudal VTA.	Morphine	66-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
10684909-3	2000	We now report that in rats given HSV-GluR1 directly into the VTA, morphine is most rewarding when maximal transgene expression is in the rostral VTA, whereas morphine is aversive when maximal transgene expression is in the caudal VTA.	Morphine	158-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	37-42
10626838-1	1999	Recently, it has been shown that a single leucine-to-tyrosine mutation in the agonist binding domains of the homomerically expressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors GluR3 and GluR1 is sufficient to completely block receptor desensitization.	Leucine	42-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
10626838-1	1999	Recently, it has been shown that a single leucine-to-tyrosine mutation in the agonist binding domains of the homomerically expressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors GluR3 and GluR1 is sufficient to completely block receptor desensitization.	Tyrosine	53-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
10626838-1	1999	Recently, it has been shown that a single leucine-to-tyrosine mutation in the agonist binding domains of the homomerically expressed alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors GluR3 and GluR1 is sufficient to completely block receptor desensitization.	isoxazole propionic	166-185	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	218-223
10629751-1	1999	This is a study of the effect of the unilateral administration of dopamine (DA) in the pars compacta of the substantia nigra (SN) of the rat on striatal glutamate receptor subunit (GluR1, GluR2 and NMDAR1) gene expression determined by in situ hybridization.	Dopamine	76-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	181-186
10629751-3	1999	The DA-induced lesions produce significant bilateral reductions in the expression of GluR1 and NMDAR1 subunit mRNA in the medio-lateral striatum, whereas the expression of striatal GluR2 receptors was not changed.	Dopamine	4-6	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	85-90
10051230-6	1999	Staining for glutamate receptor 1 was heterogeneous; about half of the tyrosine hydroxylase immunopositive cells stained intensely, while the other half were immunonegative.	Tyrosine	71-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	13-33
10622402-1	1999	The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes.	Luteinizing Hormone	87-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	151-171
10622402-1	1999	The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes.	Luteinizing Hormone	87-89	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-178
10622402-1	1999	The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes.	Excitatory Amino Acids	102-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	151-171
10622402-1	1999	The objectives of this study were to determine whether stress attenuates the pituitary LH response to excitatory amino acids by altering expression of glutamate receptor 1 (GluR1) and N-methyl-D-aspartic acid (NMDA) receptor mRNA levels in the hypothalamus or pituitary, and assess whether stress influences testicular levels of mRNA or protein for steroidogenic enzymes.	Excitatory Amino Acids	102-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-178
10191334-6	1999	Treatment of ovariectomized juvenile rats with estradiol induced expression of GluR1 mRNA but did not alter levels of GluR2 or GluR3 mRNA.	Estradiol	47-56	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	79-84
10191334-7	1999	Treatment of estrogen-primed ovariectomized juvenile rats with progesterone caused an initial increase in GluR1 mRNA expression, followed by a small decrease 24 hr after treatment.	Progesterone	63-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	106-111
10513575-7	1999	At cloned AMPA receptors, (S)-ATPA showed agonist effects at GluR3 and GluR4 with EC50 values of approximately 8 microM and at GluR1 (EC50 = 22 microM), producing maximal steady state currents only 5.4-33% of those evoked by kainic acid.	(S)-ATPA	26-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	127-132
10414446-4	1999	[3H]ACPA was shown to bind with single and similar affinities (15-45 nM) to cloned AMPA receptor subunits (GluR1-4), expressed in insect cells, whereas a K(D) value of 330 nM was determined for the binding of [3H]ACPA to cloned kainic acid preferring GluR5 subunits.	3h]acpa	1-8	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
10320779-2	1999	We have used a multiprobe oligonucleotide solution hybridization (MOSH) technique to examine the regulation of gene expression of the GluR1-7, KA1, and KA2 glutamate receptor subunits in the left rat brain following treatment with the optical isomers of flupenthixol at a dose of 0.2 mg kg-1 day-1 over a period of 4, 12, 24 weeks in order to understand how specific glutamate receptor genes are involved in the treatment of schizophrenia.	Oligonucleotides	26-41	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	134-139
10320779-2	1999	We have used a multiprobe oligonucleotide solution hybridization (MOSH) technique to examine the regulation of gene expression of the GluR1-7, KA1, and KA2 glutamate receptor subunits in the left rat brain following treatment with the optical isomers of flupenthixol at a dose of 0.2 mg kg-1 day-1 over a period of 4, 12, 24 weeks in order to understand how specific glutamate receptor genes are involved in the treatment of schizophrenia.	Flupenthixol	254-266	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	134-139
10188946-4	1999	One and two days after formalin injection, the immunostaining of cell bodies and neuropil of the AMPA receptor subunits GluR1 and GluR2/3 was markedly decreased in the ipsilateral superficial laminae of the subnucleus caudalis compared to the contralateral side.	Formaldehyde	23-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	120-125
10188946-6	1999	The down-regulation of AMPA GluR1 and GluR2/3 was no longer detectable in the subnucleus caudalis three days after formalin injection.	Formaldehyde	115-123	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
10069569-5	1999	However, exposure of low glutamine cultures to 100 mM ethanol for 4 days (starting at culture day 9) significantly increased the levels of NMDA receptor subunits (NR1, NR2A, and NR2B) and AMPA receptor subunits (GluR1 and GluR2/3), but had no effect upon kainate receptor subunits (GluR6/7) or the synapse-associated proteins synapsin I and PSD-95.	Ethanol	54-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	212-217
10069569-5	1999	However, exposure of low glutamine cultures to 100 mM ethanol for 4 days (starting at culture day 9) significantly increased the levels of NMDA receptor subunits (NR1, NR2A, and NR2B) and AMPA receptor subunits (GluR1 and GluR2/3), but had no effect upon kainate receptor subunits (GluR6/7) or the synapse-associated proteins synapsin I and PSD-95.	Glutamine	25-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	212-217
9952404-3	1999	Within 5 min after the addition of 100 microM glutamate to the culture medium, a rapid and selective redistribution of GluR1 subunits away from a subset of synaptic sites was observed.	Glutamic Acid	46-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	119-124
10210287-6	1999	Similar L-DOPA-currents were seen in oocytes co-injected with AMPA receptors, GluRs1,2,3 and 4.	Levodopa	8-14	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	78-94
10561704-0	1999	Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.	2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl)propionic acid	98-170	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	69-74
10561704-7	1999	(S)-ATPO also blocked kainic acid agonist effects at GluR1 (K(i) = 2.0 microM), GluR1+2 (K(i) = 3.6 microM), GluR3 (K(i) = 3.6 microM), GluR4 (K(i) = 6.7 microM), and GluR5 (K(i) = 23 microM), but was inactive at GluR6 and GluR6+KA2.	Kainic Acid	22-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	53-58
10561704-7	1999	(S)-ATPO also blocked kainic acid agonist effects at GluR1 (K(i) = 2.0 microM), GluR1+2 (K(i) = 3.6 microM), GluR3 (K(i) = 3.6 microM), GluR4 (K(i) = 6.7 microM), and GluR5 (K(i) = 23 microM), but was inactive at GluR6 and GluR6+KA2.	Kainic Acid	22-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
9798934-0	1998	Monitoring of brain spiking activity and autoantibodies to N-terminus domain of GluR1 subunit of AMPA receptors in blood serum of rats with cobalt-induced epilepsy.	Cobalt	140-146	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	80-85
9843643-5	1998	In the immunocytochemical study, immunoreactivity for glutamate or its ionotropic receptor subtypes, such as NR1, GluR1, GluR2/3, GluR6/7, and KA2, was examined in the median eminence of OVX rats under electron microscopy.	Glutamic Acid	54-63	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
9798934-3	1998	Rats with cobalt-induced epilepsy exhibited strong GluR1 immunoreactivity at the end of the first week after surgery compared with vehicle-treated rats.	Cobalt	10-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
9798934-4	1998	We showed that GluR1 autoantibodies in blood serum of rats with cobalt-induced epilepsy preceded the spiking activity maximum in the EEG.	Cobalt	64-70	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	15-20
9798934-6	1998	The EEG monitoring of spiking activity showed a correlation with accumulation of GluR1 autoantibodies in blood serum of rats with cobalt-induced epilepsy.	Cobalt	130-136	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	81-86
9603208-8	1998	These data indicate that high-affinity [3H]AMPA binding sites represent nonsynaptic, intracellular membrane-bound AMPA receptors that differ from synaptic receptors by at least the glycosylation state of GluR2 (and GluR1) subunits.	Tritium	40-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	215-220
9579786-2	1998	Short oligonucleotide probes specific for the messenger RNAs encoding the flip or flop splice forms of the GluR1 and GluR2 AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptor subunits, or for the messenger RNAs encoding the N-methyl-D-aspartate R1 subunit, were used.	Oligonucleotides	6-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
9502201-5	1998	The results showed that the numbers of GluR1 positive cells were significantly decreased in the substantia nigra pars compacta (SNc), pars reticulata (SNr) and pars lateralis (SNl) from 3 days (13.7%) to 3 months (40.3%) and of GluR2/3 cells, from 1 week (17.6%) to 3 months (19.1%) after 6-OHDA injection, compared to those in the contralateral non-injected side.	Oxidopamine	289-295	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	39-44
9509995-1	1998	Immunostaining for GluR1 and GluR2/3 subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is prominent in laminae I and II of the normal dorsal horn, with much less staining in deeper laminae.	amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	59-109	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	19-24
9597158-17	1998	It is believed that the supersensitivity to kainic acid, convulsions and anxiety, and the increased expression of GLuR1, R2, and R3 may be parts of the mechanism of diazepam dependence.	Diazepam	165-173	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-119
9462876-2	1997	The precise cellular localization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)-type glutamate receptor subunits (GluR1-4), one of the major family that involves in the mechanisms of glutamate excitocytotoxicity, in different populations of striatal neurons is therefore of special interest.	methyl radical	61-67	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-139
9753141-3	1998	Most (78%) of the neurones with GluR1-immunoreactivity were GABA-immunoreactive, and some of these were also glycine-immunoreactive, whereas nearly all (97%) of the GluR2/3-immunoreactive neurones were not GABA- or glycine-immunoreactive.	gamma-Aminobutyric Acid	60-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
9753141-3	1998	Most (78%) of the neurones with GluR1-immunoreactivity were GABA-immunoreactive, and some of these were also glycine-immunoreactive, whereas nearly all (97%) of the GluR2/3-immunoreactive neurones were not GABA- or glycine-immunoreactive.	gamma-Aminobutyric Acid	206-210	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
9753141-3	1998	Most (78%) of the neurones with GluR1-immunoreactivity were GABA-immunoreactive, and some of these were also glycine-immunoreactive, whereas nearly all (97%) of the GluR2/3-immunoreactive neurones were not GABA- or glycine-immunoreactive.	Glycine	215-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	32-37
9462876-2	1997	The precise cellular localization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)-type glutamate receptor subunits (GluR1-4), one of the major family that involves in the mechanisms of glutamate excitocytotoxicity, in different populations of striatal neurons is therefore of special interest.	4-isoxazole	68-79	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-139
9369338-1	1997	Immunocytochemical techniques were employed to examine the changes in immunolabeling of the alpha-amino-3-hydroxy-5-methyl-4-isoaxolepropionate (AMPA) receptor subunits GluR1 and GluR2/3 within the dentate gyrus 1, 3, 7, 14, 30, and 90 days after a unilateral perforant pathway lesion in the rat brain.	isoaxolepropionate	125-143	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
9330373-1	1997	The cellular distribution of calpain activation and glutamate receptor 1 (GluR1) subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their alterations following kainic acid-induced seizure were evaluated during postnatal development using antibodies specific for spectrin breakdown product and the C-terminus of GluR1 subunits.	Kainic Acid	192-203	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	52-72
9330373-1	1997	The cellular distribution of calpain activation and glutamate receptor 1 (GluR1) subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their alterations following kainic acid-induced seizure were evaluated during postnatal development using antibodies specific for spectrin breakdown product and the C-terminus of GluR1 subunits.	Kainic Acid	192-203	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-79
9330373-11	1997	The early increase in GluR1 immunoreactivity in hippocampal pyramidal layer following kainic acid treatment occurred throughout the developmental period, while the later decrease in CA regions, amygdala, and pyriform cortex was observed only in postnatal day 21 animals.	Kainic Acid	86-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	22-27
9406922-8	1997	In AxCAGluR1-infected cells, the current-voltage (I-V) relationship of response to kainate, a non-desensitizing agonist of AMPA receptors, exhibited a strong inward rectification, indicating the formation of functional GluR1-homomeric channels.	Kainic Acid	83-90	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	7-12
9183816-8	1997	Repeated amphetamine administration decreased levels of GluR1 and GluR2 but not GluR3 mRNAs in both core and shell subregions of the NAc at the 14 day withdrawal time; no changes were observed after 3 days of withdrawal.	Amphetamine	9-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
9261815-1	1997	The co-localization of GABA with AMPA receptor subunits GluR1 or GluR2/3 was analysed in the striate cortex of adult rats by post-embedding immunocytochemistry in semithin sections.	gamma-Aminobutyric Acid	23-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	56-61
9272640-3	1997	The AMPA analogue ACPA [(R,S)-2-amino-3(3-carboxy-5-methyl-4-isoxazolyl)propionic acid] was the most potent and selective agonist tested at GluR1(o) and GluR3(o), with a 10-fold selectivity for GluR3(o).	arachidonylcyclopropylamide	18-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
9272640-3	1997	The AMPA analogue ACPA [(R,S)-2-amino-3(3-carboxy-5-methyl-4-isoxazolyl)propionic acid] was the most potent and selective agonist tested at GluR1(o) and GluR3(o), with a 10-fold selectivity for GluR3(o).	(r,s)-2-amino-3(3-carboxy-5-methyl-4-isoxazolyl)propionic acid	24-86	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
9030617-2	1997	We detected the expression of the AMPA receptor subunits (GluR1-GluR4) in neurons in the somatosensory cortex of adult rats by combining nonradioactive in situ hybridization using digoxigenin-labeled RNA probes of GluR1 and GluR2 with immunocytochemistry using specific antibodies against GluR1, GluR2/3, and GluR4.	Digoxigenin	180-191	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
9084418-6	1997	Treatment of frozen-thawed brain sections with concentrations of calcium as low as 0.2 mM resulted in a large decrease in the 105-kDa GluR1 band and in the concurrent appearance of the 98-kDa band.	Calcium	65-72	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	134-139
8744443-12	1996	These data suggest that dopamine positively regulates only GluR1 gene expression in the GPi.	Dopamine	24-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	59-64
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	48-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	6-11
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	48-55	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	199-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	6-11
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	199-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	199-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	6-11
9059915-5	1997	Since GluR1 homomeric channels are permeable to calcium ions and are inwardly rectifying, the high GluR1 content of the layer V pyramidal neurons could render these cells particularly susceptible to calcium influx, and consequently, calcium-mediated neuronal injury.	Calcium	199-206	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	99-104
8836550-10	1996	In general, increased sbdp immunoreactivity in dendritic fields was associated with decreased GluR1 immunoreactivity.	sbdp	22-26	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
9003015-8	1997	The regulatory effect of estradiol on AMPA receptors was found to be site and gender specific: after estradiol treatment, samples taken from the hypothalamus contained increased levels of GluR1 and GluR2/3, whereas in the septum, bed nucleus and amygdala, no changes could be detected.	Estradiol	25-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	188-193
9350508-2	1997	Effects of chronic oral ethanol exposure (20% v/v, 28 weeks) on the expression of the AMPA receptor mRNA subtypes GluR-A, GluR-B and GluR-C (flip variants) were analysed in the rat hippocampus by in situ hybridization and subsequent quantitative autoradiography.	Ethanol	24-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	114-120
8793745-8	1996	The complex patterns of sensitivity to cyclothiazide seen in hippocampal neurons could be reconstituted by assembly of recombinant AMPA receptor subunits generated from cDNAs encoding the flip (i) and flop (o) splice variants of the GluR-A and GluR-B subunits.	cyclothiazide	39-52	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	233-239
8793745-11	1996	Coexpression of the flip and flop splice variants of GluR-A, in the absence of GluR-B, revealed that heteromeric AMPA receptors with intermediate sensitivity to cyclothiazide, similar to responses observed for the combinations GluR-AoBi or GluR-AiBo, could be generated independently of the presence of the GluR-B subunit.	cyclothiazide	161-174	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	53-59
8793745-12	1996	However, recovery from modulation by cyclothiazide was twofold slower for GluR-AiBi than for homomeric GluR-Ai, indicating that the GluR-A and GluR-B subunits are not functionally equivalent in controlling sensitivity to cyclothiazide.	cyclothiazide	37-50	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	74-80
8733298-3	1996	Only non-pyramidal neurons containing the calcium binding proteins parvalbumin (PV) and calbindin D-28k (CB) exhibited robust GluR1-like immunoreactivity (GluR1-ir).	Calcium	42-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	126-131
8725347-1	1996	Recent in vitro studies suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2, leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) channels.	Calcium	156-163	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
8725347-1	1996	Recent in vitro studies suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2, leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) channels.	methylisoxazole-4	198-215	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
8725347-1	1996	Recent in vitro studies suggest that inhibitory interneurons in cortex may express the GluR1 glutamate receptor subunit in the absence of GluR2, leading to calcium-permeable alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) channels.	Propionates	216-226	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	87-92
8725347-6	1996	Double immunostaining revealed that the large majority of intensely GluR1-positive cells contained gamma-aminobutyric acid or its synthetic enzyme, glutamic acid decarboxylase, but little or no GluR2.	gamma-Aminobutyric Acid	99-122	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-73
8738374-5	1996	Intravenous kainate injections resulted in a decrease in GluR1 and GluR2/3 immunoreactivity on the apical dendrites of pyramidal neurons as early as 7 h postinjection.	Kainic Acid	12-19	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
8733298-3	1996	Only non-pyramidal neurons containing the calcium binding proteins parvalbumin (PV) and calbindin D-28k (CB) exhibited robust GluR1-like immunoreactivity (GluR1-ir).	Calcium	42-49	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
8730990-1	1996	We have studied the presence and distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR1, 2, 3, and 4) in the adult cat visual cortical areas 17, 18, 19, and the lateral suprasylvian areas (LSA).	-hydroxy-5-methyl-4-isoxazolepropionate	62-101	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	148-166
9118313-2	1996	We examined the regulation, by haloperidol (2 mg kg-1 day-1) and clozapine (20 mg kg-1 day-1), of the mRNAs encoding the four AMPA receptor subunits (gluR1-gluR4), three low-affinity kainate receptor subunits (gluR5-gluR7), and two high-affinity kainate subunits (KA1 and KA2) in the rat hippocampal formation and associated entorhinal cortex.	Clozapine	65-74	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	150-155
8613793-3	1996	By immunoblotting procedures using subunit-specific antibodies, we found that repeated, but not acute, cocaine treatment increased the levels of immunoreactivity of GluR1 (an AMPA receptor subunit) and NMDAR1 (an NMDA receptor subunit) in the ventral tegmental area (VTA), a nucleus containing mesolimbic DA neurons.	Cocaine	103-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
8613793-7	1996	Although morphine delivered by subcutaneous pellet implantation had no significant effect on subunit levels, morphine delivered intermittently by subcutaneous injections of escalating doses elevated GluR1 levels in the VTA.	Morphine	109-117	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	199-204
8730990-3	1996	In situ hybridization (ISH) using digoxigenin-labeled riboprobes showed that mRNAs coding for GluR1 and GluR3 were located in cells in all layers of the areas examined and also in the underlying white matter.	Digoxigenin	34-45	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
7618490-0	1995	Changes in dopamine D2 and GluR-1 glutamate receptor mRNAs in the rat brain after treatment with phencyclidine.	Phencyclidine	97-110	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	27-33
8848293-4	1995	Another peptide containing Thr-692 of a rat GluRA, clone almost identical to GluR1, was phosphorylated by PKC but not by PKG.	Threonine	27-30	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	77-82
7595547-0	1995	Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	53-57	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	75-80
8595208-2	1995	When compared with the contralateral striatum, levels of NMDAR1, GluR1 and GluR2 mRNAs were significantly higher in the dopamine-deafferented striatum.	Dopamine	120-128	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
8595208-3	1995	Comparison with saline-injected rats showed that the NMDAR1 and the GluR1 mRNA labelling was increased in the striatum ipsilateral to the lesion.	Sodium Chloride	16-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-73
7618490-3	1995	However, chronic administration of phencyclidine (10 mg/kg/day, 14 days) significantly decreased the dopamine D2-receptor mRNA level in the caudate-putamen (by 27%, P < 0.01) and significantly increased the GluR-1 mRNA level in the prefrontal cortex (by 29%, P < 0.001).	Phencyclidine	35-48	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	210-216
7618490-1	1995	In situ hybridization of slide-mounted brain sections from rats subjected to acute and chronic phencyclidine treatment was carried out using synthetic oligonucleotides complementary to dopamine D2-receptor and non-N-methyl-D-aspartate (NMDA) glutamate-receptor-subunit (GluR-1) mRNAs.	Phencyclidine	95-108	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	210-276
7958168-19	1994	In contrast, AMPA receptor (GluR1) immunoreactive levels in the magnocellular preoptic area (mPOA), the arcuate nucleus (ARC), and the suprachiasmatic nucleus (SCN) were found to be markedly elevated during the time of the LH surge in estradiol-progesterone-treated castrate rats compared to those of the vehicle-only-treated castrate rat.	Estradiol	235-244	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
7538168-1	1995	The levels of mRNAs for the subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptors (GluR-1, -2, -3, -4) in the rat hippocampus during aging were measured by Northern blotting.	methyl-4-isoxazole	64-82	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	132-150
7898626-11	1995	Steroids have been reported not to affect NMDA receptor binding in the hypothalamus; however, steroids appear to up-regulate AMPA receptor GluR1 subunit levels and non-NMDA receptor binding in the hypothalamus.	Steroids	94-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	139-144
7958168-19	1994	In contrast, AMPA receptor (GluR1) immunoreactive levels in the magnocellular preoptic area (mPOA), the arcuate nucleus (ARC), and the suprachiasmatic nucleus (SCN) were found to be markedly elevated during the time of the LH surge in estradiol-progesterone-treated castrate rats compared to those of the vehicle-only-treated castrate rat.	Progesterone	245-257	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
7690404-1	1993	Antagonism of rat excitatory amino acid receptors by a synthetic analog [philanthotoxin-343 (PhTX-343)] of a polyamine amide, wasp toxin (philanthotoxin-433) and a structurally related spider toxin, argiotoxin-636 (ArgTX-636), was examined in Xenopus oocytes injected with rat brain RNA or RNA transcribed from the excitatory amino acid receptor clones GluR1, GluR2 and NMDAR1.	Philanthotoxin	73-87	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	353-358
7725830-4	1994	Furthermore, the expression of GluR1 in gonadotrophs (and thus these cells" ability to respond to glutamate) may be regulated by gonadal factors.	Glutamic Acid	98-107	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	31-36
7690404-6	1993	PhTX-343 and ArgTX-636 were more or less equally potent (IC50s were 2.8 microM and 3.4 microM, respectively) antagonists of the response of GluR1 to 100 microM kainate.	phtx	0-4	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
7690404-6	1993	PhTX-343 and ArgTX-636 were more or less equally potent (IC50s were 2.8 microM and 3.4 microM, respectively) antagonists of the response of GluR1 to 100 microM kainate.	argiotoxin-636	13-22	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
7690404-6	1993	PhTX-343 and ArgTX-636 were more or less equally potent (IC50s were 2.8 microM and 3.4 microM, respectively) antagonists of the response of GluR1 to 100 microM kainate.	Kainic Acid	160-167	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	140-145
7684447-6	1993	Oocytes injected with mRNA transcribed from the GluR1 clone encoding a rat non-NMDA receptor subunit did not respond to NMDA, and antagonism of the response to kainate occurred only with millimolar concentrations of NMDA and was competitive.	N-Methylaspartate	79-83	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	48-53
8492909-1	1993	Antibodies were made to synthetic peptides corresponding to residues 253-367, 757-771 and 877-889 of the published amino acid sequence of the rat brain glutamate receptor GluR1 subunit [Hollmann et al.	Peptides	34-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	171-176
8496162-8	1993	Coexpression of a plasmid for GH and a plasmid for the non-N-methyl-D-aspartate glutamate receptor, GluR1, created chromaffin cells in which Ca(2+)-dependent GH secretion could be stimulated by the glutamatergic agonist kainate.	Kainic Acid	220-227	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	100-105
8386757-4	1993	In rat, GluR1 does not colocalize with ChAT, but, within many neurons, GluR1 does colocalize with GABA, glutamic acid decarboxylase (GAD), and parvalbumin immunoreactivities.	gamma-Aminobutyric Acid	98-102	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	71-76
8386757-6	1993	In monkey, however, most GluR1-immunoreactive neurons express ChAT and calbindin-D28 immunoreactivities.	calbindin-d28	71-84	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
8492909-11	1993	GluR1 was immunoaffinity-purified using subunit-specific antibodies against both N-terminal (253-267) and C-terminal (877-889) residues, covalently attached to protein A-agarose.	Sepharose	170-177	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	0-5
8450957-1	1993	The messenger RNA expression of non-N-methyl-D-aspartate glutamate receptor subunits (GluR1-4), considered alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid type, was investigated in rat brain by in situ hybridization histochemistry using oligonucleotide probes specific to each subunit sequence.	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	107-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-93
8450957-1	1993	The messenger RNA expression of non-N-methyl-D-aspartate glutamate receptor subunits (GluR1-4), considered alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid type, was investigated in rat brain by in situ hybridization histochemistry using oligonucleotide probes specific to each subunit sequence.	Oligonucleotides	247-262	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-93
1407659-1	1992	The expression of five genes (GluR A; B; C; D; GluR 5) encoding functional subunits of glutamate receptors was investigated in the rat retina using in situ hybridization with oligonucleotide probes.	Oligonucleotides	175-190	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	30-36
1281252-4	1992	In GluR1-expressed oocytes, 1 mM aniracetam potentiated AMPA-induced currents by 99 +/- 10% (mean +/- S.E.M., n = 5) and glutamate-induced currents by 140 +/- 8% (n = 4), but little affected kainate-induced currents.	aniracetam	33-43	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	3-8
1281252-6	1992	In oocytes injected with GluR1 plus GluR2 RNAs, aniracetam more markedly potentiated current responses to AMPA and glutamate than those in oocytes injected with GluR1 RNA alone.	aniracetam	48-58	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
1281252-6	1992	In oocytes injected with GluR1 plus GluR2 RNAs, aniracetam more markedly potentiated current responses to AMPA and glutamate than those in oocytes injected with GluR1 RNA alone.	Glutamic Acid	115-124	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	25-30
1281252-7	1992	For example, 1 mM aniracetam potentiated AMPA-induced currents by 396 +/- 76% (n = 4) and glutamate-induced currents by 970 +/- 65% (n = 5) in oocytes injected with 10% GluR1 and 90% GluR2 RNAs.	aniracetam	18-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	169-174
1317970-2	1992	These channels are assembled from the GluR-A, -B, -C, and -D subunits; channels containing a GluR-B subunit show an outwardly rectifying current-voltage relation and low calcium permeability, whereas channels lacking the GluR-B subunit are characterized by a doubly rectifying current-voltage relation and high calcium permeability.	Calcium	170-177	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-60
1317970-2	1992	These channels are assembled from the GluR-A, -B, -C, and -D subunits; channels containing a GluR-B subunit show an outwardly rectifying current-voltage relation and low calcium permeability, whereas channels lacking the GluR-B subunit are characterized by a doubly rectifying current-voltage relation and high calcium permeability.	Calcium	311-318	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-60
2176160-5	1990	These studies show that the glu receptor complex, GluR-A, binds AMPA but not KA and suggest that (i) the binding sites for these two ligands reside on different proteins, and (ii) the KA receptor identified physiologically is not equivalent to the KA binding sites identified with 3H-labelled KA.	Tritium	281-283	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	50-56
1851996-11	1991	The finding of differential developmental regulation of the GluR-1, -2, and -3 genes indicates that the receptors they encode may have different influences on synaptic plasticity, neuronal survival, and susceptibility to excitatory amino acid toxicity.	Excitatory Amino Acids	221-242	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	60-78
33591492-5	2022	Inflammation and cognitive-related markers (presynaptic synapsin PSD95, postsynaptic PSD93, postsynaptic GluR1, and GluR2) were improved in HFD rats administered Mg, with more significant effects seen in the MgPic group.	Magnesium	162-164	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	105-110
33779892-8	2021	Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats.	Remifentanil	166-178	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	107-112
33779892-8	2021	Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats.	Remifentanil	166-178	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	124-130
33779892-3	2021	In this study, we investigated whether the impairment of transmembrane protein 16C (TMEM16C)/Slack is required for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor (AMPAR) activation in remifentanil-induced postoperative hyperalgesia.	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic	115-166	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	177-182
34428447-10	2021	Moreover, PCC-0105002 altered signaling downstream of NMDAR and thus functionally and structurally attenuating synaptic plasticity through respective regulation of the NR2B/GluR1/CaMKIIalpha and Rac1/RhoA pathways.	pcc-0105002	10-21	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	173-178
34710402-5	2022	The results showed that L-VP reduced the number of neurons and astrocytes in the mPFC and decreased the number of dendritic spines, dendrite complexity, LTP, LTD, PPR, and expression of glutamate receptors (GluR1, GluR2, GluR3, NMDAR2A, and NMDAR2B) and BDNF in the mPFC.	l-vp	24-28	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	207-212
34673477-15	2022	With the increase of Al dose, the relative expression of NMDAR1, NMDAR2A, NMDAR2B, GluR1 and mGluR5 in cerebral cortex and lymphocytes of rats were decreased (P < 0.05).	Aluminum	21-23	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	83-88
34463942-9	2021	Simultaneously, EGb761 and its monomer component ginkgolides inhibited the post-ischemic LTP (i-LTP) by inhibiting the EPSCs and the AMPA receptor subunit GluA1 expression on postsynaptic membrane.	Ginkgolides	49-60	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	155-160
34390773-2	2021	Topiramate (TPM), an AMPAR antagonist, has been used to treat psychostimulants addiction, despite its harmful effects on memory.	Topiramate	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	21-26
34390773-2	2021	Topiramate (TPM), an AMPAR antagonist, has been used to treat psychostimulants addiction, despite its harmful effects on memory.	Topiramate	12-15	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	21-26
34390773-6	2021	In the NAc, morphine increased D1R, D2R, D3R, DAT, GluA1 and MOR immunoreactivity.	nac	7-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
34390773-6	2021	In the NAc, morphine increased D1R, D2R, D3R, DAT, GluA1 and MOR immunoreactivity.	Morphine	12-20	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
34390773-8	2021	TPM-CS-NP treatment decreased D1R, D3R and GluA1 and increased DAT in the NAc, decreasing GluA1 and increasing D2 and DAT in the dorsal hippocampus.	tpm-cs-np	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	43-48
34390773-8	2021	TPM-CS-NP treatment decreased D1R, D3R and GluA1 and increased DAT in the NAc, decreasing GluA1 and increasing D2 and DAT in the dorsal hippocampus.	tpm-cs-np	0-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
35280167-7	2022	Furthermore, NAC normalized the altered GSH levels displayed by these animals in the hippocampus and nucleus accumbens, and it partially rescued the altered expression of post-synaptic terminal network genes found in VPA-exposed rats, such as NR2a, MGLUR5, GLUR1, and GLUR2 in nucleus accumbens, and CAMK2, NR1, and GLUR2 in cerebellum.	Acetylcysteine	13-16	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	257-262
34565308-0	2021	Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats.	cyclic glycine	18-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-135
34565308-0	2021	Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats.	Proline	33-40	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	129-135
34565308-8	2021	cGP-treated group also showed longer, larger and more astrocytic processes, more capillaries and higher glutamate receptor-1 expression.	cyclic glycine-proline	0-3	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	104-124
34280506-11	2021	Consistent with increased pain-related behavior, chronic alcohol drinking increased GluR1, NR1, ERK, and CREB phosphorylation in the cingulate cortex.	Alcohols	57-64	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	84-89
34184955-4	2021	Furthermore, N-cadherin and AMPAR subunit GluA1 were colocalized in the PFC, and the expression of the N-cadherin and the GluA1 decreased following PS exposure in male offspring rats.	ps	148-150	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	42-47
34184955-4	2021	Furthermore, N-cadherin and AMPAR subunit GluA1 were colocalized in the PFC, and the expression of the N-cadherin and the GluA1 decreased following PS exposure in male offspring rats.	ps	148-150	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
34184955-5	2021	We also found that the AMPAR agonist CX546 did not alleviate anxiety-like behavior in adolescent male offspring rats; however, it increased the expression of GluA1 in the PFC but did not alter the expression of N-cadherin.	1-(1,4-benzodioxan-6-ylcarbonyl)piperidine	37-42	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	158-163
34184955-6	2021	In conclusion, our study suggested that the N-cadherin-GluA1 pathway in the PFC mediates anxiety-like behavior in adolescent male offspring rats and that N-cadherin might be required for sex differences in the effect of PS on adolescent offspring.	ps	220-222	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	55-60
34440273-1	2021	The neural precursor cell expressed by developmentally downregulated gene 4-2 (NEDD4-2) is a ubiquitin E3 ligase that has a high affinity toward binding and ubiquitinating glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type subunit 1 (GRIA1, also referred to GluR1 or GluA1).	Glutamic Acid	172-181	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	282-287
34440273-1	2021	The neural precursor cell expressed by developmentally downregulated gene 4-2 (NEDD4-2) is a ubiquitin E3 ligase that has a high affinity toward binding and ubiquitinating glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type subunit 1 (GRIA1, also referred to GluR1 or GluA1).	Glutamic Acid	172-181	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	306-311
34440273-1	2021	The neural precursor cell expressed by developmentally downregulated gene 4-2 (NEDD4-2) is a ubiquitin E3 ligase that has a high affinity toward binding and ubiquitinating glutamate ionotropic receptor alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type subunit 1 (GRIA1, also referred to GluR1 or GluA1).	Glutamic Acid	172-181	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	315-320
34440273-2	2021	Since dysregulation of GRIA1 surface expression is relevant to the responsiveness to AMPA receptor (AMPAR) antagonists (perampanel and GYKI 52466) in chronic epilepsy rats, it is likely that NEDD4-2 may be involved in the pathogenesis of intractable epilepsy.	perampanel	120-130	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	23-28
34440273-2	2021	Since dysregulation of GRIA1 surface expression is relevant to the responsiveness to AMPA receptor (AMPAR) antagonists (perampanel and GYKI 52466) in chronic epilepsy rats, it is likely that NEDD4-2 may be involved in the pathogenesis of intractable epilepsy.	GYKI 52466	135-145	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	23-28
34440273-4	2021	In the present study, both AMPAR antagonists recovered the impaired GRIA1 ubiquitination by regulating protein phosphatase 2B (PP2B)-extracellular signal-regulated kinase 1/2 (ERK1/2)-serum and glucocorticoid-regulated kinase 1 (SGK1)-NEDD4-2 signaling pathway in responders (whose seizure activities are responsive to AMPAR), but not non-responders (whose seizure activities were uncontrolled by AMPAR antagonists).	ampar	27-32	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-73
34440273-4	2021	In the present study, both AMPAR antagonists recovered the impaired GRIA1 ubiquitination by regulating protein phosphatase 2B (PP2B)-extracellular signal-regulated kinase 1/2 (ERK1/2)-serum and glucocorticoid-regulated kinase 1 (SGK1)-NEDD4-2 signaling pathway in responders (whose seizure activities are responsive to AMPAR), but not non-responders (whose seizure activities were uncontrolled by AMPAR antagonists).	ampar	397-402	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	68-73
35415819-6	2022	The palmitoylation levels of GluR1 and GluR2 were detected by immunoprecipitation-acyl-biotin exchange (IP-ABE) assay.	acyl-biotin	82-93	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	29-34
35415819-9	2022	With increasing Al(mal)3 doses administered to PC12 cells, a gradual decrease in the trafficking of AMPA receptor subunits GluR1 and GluR2 and in the palmitoylation levels of GluR1 and GluR2 was found; the expression of zDHHC3 was decreased; and the expression of PPT1 was increased.	Aluminum	16-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	123-128
35415819-9	2022	With increasing Al(mal)3 doses administered to PC12 cells, a gradual decrease in the trafficking of AMPA receptor subunits GluR1 and GluR2 and in the palmitoylation levels of GluR1 and GluR2 was found; the expression of zDHHC3 was decreased; and the expression of PPT1 was increased.	Aluminum	16-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	175-180
35337135-8	2022	NLX-101 also produced an increase in the activation of pmTOR, pERK1/2 and pAkt, and the expression of PSD95 and GluA1, which may contribute to its rapid antidepressant action.	3-chloro-4-fluorophenyl-(4-fluoro-4-(((5-methylpyrimidin-2-ylmethyl)amino)methyl)piperidin-1-yl)methanone	0-7	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
34481424-10	2021	Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP-seeking after prolonged abstinence in IC-AMP rats.	Amphetamine	94-97	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
34481424-10	2021	Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP-seeking after prolonged abstinence in IC-AMP rats.	Amphetamine	177-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
34481424-10	2021	Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP-seeking after prolonged abstinence in IC-AMP rats.	Amphetamine	177-180	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	133-138
34481424-10	2021	Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP-seeking after prolonged abstinence in IC-AMP rats.	Amphetamine	222-225	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	58-63
34481424-10	2021	Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP-seeking after prolonged abstinence in IC-AMP rats.	Amphetamine	222-225	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	133-138
34417282-8	2021	Other affected components of RA signaling include selective increases in AI animals in hippocampal synthesis (RALDH1) and catabolism of RA (CYP26B1), RA receptor alpha, the RA regulated ionotropic glutamate receptor (GluR1), as well as fragile X mental retardation protein.	Tretinoin	29-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	217-222
35227653-12	2022	Compared with the model group, the expression of GluR1 protein in the EA, DNQX, and DNQX + EA group was decreased, but similar among the three treatment groups, supporting the histopathological observations.	FG 9041	74-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
35227653-12	2022	Compared with the model group, the expression of GluR1 protein in the EA, DNQX, and DNQX + EA group was decreased, but similar among the three treatment groups, supporting the histopathological observations.	FG 9041	84-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
35535260-2	2022	Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 within rat hippocampal CA3 pyramidal cells following oxycodone (Oxy) conditioned place preference (CPP).	Oxycodone	225-234	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
35535260-2	2022	Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 within rat hippocampal CA3 pyramidal cells following oxycodone (Oxy) conditioned place preference (CPP).	Oxycodone	236-239	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	166-171
35535260-12	2022	Together with our prior experiments, these changes in GluN1 and GluA1 following CIS in males may contribute to an increased sensitivity of CA3 neurons to glutamate excitation and a reduced capacity to acquire Oxy CPP.	Glutamic Acid	154-163	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	64-69
33243008-2	2021	The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected.	propionic acid	57-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
35128865-8	2022	Compared with the model group, both EA and SCOP remarkably increased the sucrose preference (P<0.001), shortened the feeding latency (P<0.001), up-regulated the BDNF, mTORC1, p-mTORC1, PSD95, Synapsin I, and GluR1 expression in PFC(P<0.05,P<0.01,P<0.001), and elevated the total and immature spine dendritic densities (P<0.001,P<0.01).	Scopolamine	43-47	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	208-213
33243008-2	2021	The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected.	propionic acid	57-71	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-124
33243008-2	2021	The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected.	melamine	154-162	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	82-87
33243008-2	2021	The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected.	melamine	154-162	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	97-124
34053000-9	2021	Interestingly, STZ + PBM rats had a decrease in 70.7% of GluR1 protein level in the ACC.	Streptozocin	15-18	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
34053000-9	2021	Interestingly, STZ + PBM rats had a decrease in 70.7% of GluR1 protein level in the ACC.	pbm	21-24	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-62
33723767-7	2021	In fact, ketamine in the mPFC decreased the level of GLT-1 and increased the level of GluN2B, GluA1, GluA2, and scaffolding proteins, likely indicating a pattern of enhanced excitability.	Ketamine	9-17	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	94-99
33991493-12	2021	Compared with the model group, the expression of GluR1 protein in the EA, DNQX, and DNQX+EA group was decreased, but similar among the three treatment groups, supporting the histopathological observations.	FG 9041	74-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
33991493-12	2021	Compared with the model group, the expression of GluR1 protein in the EA, DNQX, and DNQX+EA group was decreased, but similar among the three treatment groups, supporting the histopathological observations.	FG 9041	84-88	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	49-54
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	perampanel	179-189	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-106
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	perampanel	179-189	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	GYKI 52466	194-204	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-106
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	GYKI 52466	194-204	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	Lithium Chloride	209-213	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-106
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	Lithium Chloride	209-213	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	Pilocarpine	214-225	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	57-106
33919872-2	2021	Although maladaptive regulation of surface expression of glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) subunit is relevant to the responsiveness to AMPAR antagonists (perampanel and GYKI 52466) in LiCl-pilocarpine-induced chronic epilepsy rats, the underlying mechanisms of refractory seizures to AMPAR antagonists have yet been unclear.	Pilocarpine	214-225	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	108-113
33919872-3	2021	In the present study, we found that both AMPAR antagonists restored the up-regulations of GRIA1 surface expression and Src family-mediated glycogen synthase kinase 3beta (GSK3beta)-Ca2+/cAMP response element-binding protein (CREB) phosphorylations to control levels in responders (whose seizure activities were responsive to AMPAR) but not non-responders (whose seizure activities were uncontrolled by AMPAR antagonists).	ampar	41-46	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
33919872-3	2021	In the present study, we found that both AMPAR antagonists restored the up-regulations of GRIA1 surface expression and Src family-mediated glycogen synthase kinase 3beta (GSK3beta)-Ca2+/cAMP response element-binding protein (CREB) phosphorylations to control levels in responders (whose seizure activities were responsive to AMPAR) but not non-responders (whose seizure activities were uncontrolled by AMPAR antagonists).	Cyclic AMP	186-190	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
33919872-3	2021	In the present study, we found that both AMPAR antagonists restored the up-regulations of GRIA1 surface expression and Src family-mediated glycogen synthase kinase 3beta (GSK3beta)-Ca2+/cAMP response element-binding protein (CREB) phosphorylations to control levels in responders (whose seizure activities were responsive to AMPAR) but not non-responders (whose seizure activities were uncontrolled by AMPAR antagonists).	ampar	325-330	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	90-95
33919872-4	2021	In addition, 3-chloroacetyl indole (3CAI, an AKT inhibitor) co-treatment attenuated spontaneous seizure activities in non-responders, accompanied by reductions in AKT/GSK3beta/CREB phosphorylations and GRIA1 surface expression.	3-chloroacetylindole	13-34	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	202-207
33994921-10	2021	Results: Offspring prenatally exposed to VPA showed autism-like behavior, upregulated the levels of LTP and GluN2A, GluA1, and SYN1 proteins relevant to synaptic plasticity in the PFC.	Valproic Acid	41-44	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	116-121
33994921-15	2021	After RA supplementation in the VPA-treated offspring, the RA and RARalpha protein levels were significantly upregulated, GluA1 protein and LTP were downregulated, and most autism-like behavioral deficits were effectively reversed.	Valproic Acid	32-35	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	122-127
33882624-9	2021	At the molecular level, fisetin treatment selectively increased the phosphorylation and surface expression of AMPA receptor subunit 1 (GluA1) in MK-801-treated rats.	fisetin	24-31	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	135-140
33882624-9	2021	At the molecular level, fisetin treatment selectively increased the phosphorylation and surface expression of AMPA receptor subunit 1 (GluA1) in MK-801-treated rats.	Dizocilpine Maleate	145-151	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	135-140
33643051-5	2021	Furthermore, we found that repeated treatment with YL-0919 significantly reversed the accompanying decreased expression of the brain-derived neurotrophic factor (BDNF) and the synaptic proteins (synapsin1 and GluA1), and ameliorated the neuroplasticity disruption in the prefrontal cortex (PFC), including the dendritic complexity and spine density of pyramidal neurons.	1-(1-benzyl-4-hydroxypiperidin-4-ylmethyl)-2(1H)-pyridinone	51-58	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	209-214
33321179-6	2021	At euthanasia, synaptoneurosomes were isolated from a subset of brains to examine the expression of two proteins associated with alcohol drinking-related behaviors, GluA1 and SK2, in the dorsal (dHC) and ventral hippocampus (vHC).	Alcohols	129-136	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	165-170
33385944-4	2021	The results showed that both the mRNA and protein expression of GluR1 and NR2B were significantly downregulated in the hippocampus of PTZ-kindled rats, while KD could observably improve both the mRNA and protein expression of GluR1 and NR2B in the hippocampus of PTZ-kindled rats.	Pentylenetetrazole	134-137	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	64-69
33385944-4	2021	The results showed that both the mRNA and protein expression of GluR1 and NR2B were significantly downregulated in the hippocampus of PTZ-kindled rats, while KD could observably improve both the mRNA and protein expression of GluR1 and NR2B in the hippocampus of PTZ-kindled rats.	Pentylenetetrazole	134-137	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	226-231
33385944-4	2021	The results showed that both the mRNA and protein expression of GluR1 and NR2B were significantly downregulated in the hippocampus of PTZ-kindled rats, while KD could observably improve both the mRNA and protein expression of GluR1 and NR2B in the hippocampus of PTZ-kindled rats.	Pentylenetetrazole	263-266	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	64-69
33361540-4	2021	Interestingly, compared to saline exposure, cocaine significantly increased the immunofluorescence intensity of GluA1 in two sub-regions, the core and the shell, of the NAcc on withdrawal day 21 following cocaine exposure, which led to locomotor sensitization.	Sodium Chloride	27-33	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
33536871-8	2020	Changes in GluA1-3, Grm6, and Grm8 mRNA levels also correlated with increased lever pressing (incubation) after long periods of withdrawal from oxycodone.	Oxycodone	144-153	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	11-18
33249277-12	2021	In contrast, it increased Norbin expression in PFC and amygdala, and attenuated NR1 and GluR1 upregulation following tramadol at high dose.	Tramadol	117-125	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
33249277-13	2021	These findings indicated that preconditioning by ultra-low dose of tramadol protected the animals against seizures following high dose of tramadol mediated, at least in part, by Norbin up regulation, and NR1 and GluR1 down regulation.	Tramadol	67-75	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	212-217
33211807-7	2021	Furthermore, maternal HFD exposure enhanced the palmitoylation of GluA1 critically involved in long-term potentiation induction, while palmitoylation inhibitor 2-bromopalmitate counteracts GluA1 hyper-palmitoylation and partially abolishes the detrimental effects of maternal diet on learning and memory in F3 offspring.	2-bromopalmitate	160-176	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	189-194
33361540-4	2021	Interestingly, compared to saline exposure, cocaine significantly increased the immunofluorescence intensity of GluA1 in two sub-regions, the core and the shell, of the NAcc on withdrawal day 21 following cocaine exposure, which led to locomotor sensitization.	Cocaine	44-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117
33361540-4	2021	Interestingly, compared to saline exposure, cocaine significantly increased the immunofluorescence intensity of GluA1 in two sub-regions, the core and the shell, of the NAcc on withdrawal day 21 following cocaine exposure, which led to locomotor sensitization.	Cocaine	205-212	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	112-117