PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34744512-8 2021 The levels of IL-27 were positively correlated with Crohn"s disease activity index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin (FC), and Simple Endoscopic Score for Crohn"s Disease (SES-CD) and negatively correlated with hemoglobin (Hb) and serum albumin (ALB). ses-cd 229-235 interleukin 27 Homo sapiens 14-19 34956579-1 2021 Objective: To investigate the correlation between changes in serum RBP4, hs-CRP, and IL-27 levels and rosuvastatin in the treatment of coronary heart disease (CHD). Rosuvastatin Calcium 102-114 interleukin 27 Homo sapiens 85-90 34956579-11 2021 Meanwhile, rosuvastatin can remarkably reduce serum RBP4, hs-CRP, and IL-27 levels, which is of significance for prognosis. Rosuvastatin Calcium 11-23 interleukin 27 Homo sapiens 70-75 34597998-0 2021 IL-30 ameliorates imiquimod and K14-VEGF induced psoriasis-like disease by inhibiting both innate and adaptive immunity disorders. Imiquimod 18-27 interleukin 27 Homo sapiens 0-5 34597998-5 2021 In vivo, IL-30 inhibited the development of skin disease in two animal models: Krt14-Vegfa and imiquimod (IMQ)-induced psoriasis-like skin disease. Imiquimod 95-104 interleukin 27 Homo sapiens 9-14 34597998-5 2021 In vivo, IL-30 inhibited the development of skin disease in two animal models: Krt14-Vegfa and imiquimod (IMQ)-induced psoriasis-like skin disease. Imiquimod 106-109 interleukin 27 Homo sapiens 9-14 34335091-2 2021 In this study, we investigated the associations between serum IL-27, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL-27 level for disease activity. CHEMBL2031461 106-109 interleukin 27 Homo sapiens 62-67 34566972-7 2021 Secretion of IL-27, IL-1Ra, IL-12, IL-33, IL-9, and SDF-1 was increased under diabetes conditions with increased Th9 polarization and increased expression of Cox-2 and IDO. TH9 113-116 interleukin 27 Homo sapiens 13-18 34335091-11 2021 These results suggest that serum IL-27 level is associated with the cross-sectional activity and the presence of renal manifestation and could be used to predict high disease activity in patients with AAV. CHEMBL2031461 201-204 interleukin 27 Homo sapiens 33-38 33601420-9 2021 Colocalization analysis identified a locus on chromosome 16 with polymorphisms in IL27, SULT1A2, and SH2B1, that reached genome-wide statistical significance in GWAS (p < 7.7e-9) for both alcohol consumption and IBD risk. Alcohols 188-195 interleukin 27 Homo sapiens 82-86 34953118-7 2021 Considering the distribution of serum levels for IL-27 by SNP, it was observed that IL-27 serum levels for TT, TC, and CC genotypes elevated in the patient group versus the control group. Technetium 111-113 interleukin 27 Homo sapiens 84-89 34953118-8 2021 In addition, it was observed elevation serum level of IL-27 for the genotypes TT, TC, and CC in recurrent abortion with toxoplasmosis in contrast to healthy women, pregnant women, and recurrent abortion (P<0.05). Technetium 82-84 interleukin 27 Homo sapiens 54-59 34953118-9 2021 Also, in recurrent abortion, the level of IL-27 for TC, and CC genotype showed significant differences comparing to healthy and pregnant women (P<0.05). Technetium 52-54 interleukin 27 Homo sapiens 42-47 35064378-2 2022 Paraffin tissues from patients with OLP, OLK, and OSCC were collected, and the expression of IL-27 in the above tissues was detected by immunohistochemical (IHC) staining. Paraffin 0-8 interleukin 27 Homo sapiens 93-98 35524472-5 2022 IL-27 levels were associated with lower odds of GDM (adjusted logistic regression (adOR)=0.90, p=2.4E-03) and revealed risk association with glutamic acid decarboxylase autoantibody (GADA) positivity (aOR=1.13, p=2.8E-03). gada 183-187 interleukin 27 Homo sapiens 0-5 35132413-8 2022 Combination NP-adjuvants targeting both TLR and RIG-I (MPLA+PUUC, CpG+PUUC, or R848+PUUC) differentially increased proinflammatory cytokine secretion (IL-1beta, IL-12p70, IL-27, IFN-beta) by APCs cultured in vitro, and induced differential T cell proliferation. np-adjuvants 12-24 interleukin 27 Homo sapiens 171-176 33478780-1 2021 OBJECTIVE: This study aims to explore the serum levels of IL-27 and the percentages of IL-27-producing cells in MG patients with positive acetylcholine receptor antibody (AChR-MG). Acetylcholine 138-151 interleukin 27 Homo sapiens 87-92 33635005-3 2021 The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. tnbc 36-40 interleukin 27 Homo sapiens 23-27 33558374-5 2021 Agonistic alphaCD40 decreased intratumoral IL-27-producing myeloid cells, decreased IL-10-producing intratumoral T cells, and promoted intratumoral Klrg1+Gzmb+ short-lived effector T cells. alphacd40 10-19 interleukin 27 Homo sapiens 43-48 32886659-8 2020 The influence of genes associated with immune regulation (CD274/PD-L1 and IL27), immune signalling (TLR2, TLR8) and antigen presentation (RFX5, HLA-5 and HLA-DOB) were highlighted in the early host response to CS. Cesium 210-212 interleukin 27 Homo sapiens 74-78 33240420-6 2021 The data obtained revealed that the expression of IL-27 with cisplatin, significantly suppressed the proliferation and apoptosis of A549 cells compared with that in the cisplatin treatment group alone. Cisplatin 61-70 interleukin 27 Homo sapiens 50-55 33240420-6 2021 The data obtained revealed that the expression of IL-27 with cisplatin, significantly suppressed the proliferation and apoptosis of A549 cells compared with that in the cisplatin treatment group alone. Cisplatin 169-178 interleukin 27 Homo sapiens 50-55 33171361-8 2020 In vitro, dexamethasone could decrease the expression of IL-27 in THP-1 cell line. Dexamethasone 10-23 interleukin 27 Homo sapiens 57-62 33294255-0 2020 Is AAV-delivered IL-27 a potential immunotherapeutic for cancer? CHEMBL2031461 3-6 interleukin 27 Homo sapiens 17-24 32483835-0 2020 Glycosaminoglycans bind human IL-27 and regulate its activity. Glycosaminoglycans 0-18 interleukin 27 Homo sapiens 30-35 32483835-4 2020 Here, we show that different glycosaminoglycans (GAGs) modulate human IL-27 activity in vitro. Glycosaminoglycans 29-47 interleukin 27 Homo sapiens 70-75 32483835-5 2020 We find that soluble heparin and heparan sulfate efficiently inhibit human IL-27 activity as shown by decreased STAT signaling and downstream biological effects. Heparin 21-28 interleukin 27 Homo sapiens 75-80 32483835-5 2020 We find that soluble heparin and heparan sulfate efficiently inhibit human IL-27 activity as shown by decreased STAT signaling and downstream biological effects. Heparitin Sulfate 33-48 interleukin 27 Homo sapiens 75-80 32483835-6 2020 In contrast, membrane-bound heparan sulfate seems to positively regulate IL-27 activity. Heparitin Sulfate 28-43 interleukin 27 Homo sapiens 73-78 32483835-10 2020 Together, our data identify GAGs as new players in the regulation of human IL-27 activity that might act under physiological conditions and may also have a clinical impact in heparin-treated patients. Heparin 175-182 interleukin 27 Homo sapiens 75-80 32307922-13 2020 CONCLUSION: Our data indicate that the physiologic ability of IL-27 to limit the magnitude and function of ELS through control of Th17 cell expansion is severely impaired in SS patients, highlighting a defective immunoregulatory checkpoint in this condition. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 107-110 interleukin 27 Homo sapiens 62-67 32320824-10 2020 CONCLUSIONS: The polymorphisms of IL27, rs17855750, but not rs181206 and rs26528, plays a protective role on the susceptibility to TB. Terbium 131-133 interleukin 27 Homo sapiens 34-38 28741232-6 2018 Besides, IL-27 concentration in aqueous humor was positively correlated with serum glucose, lipid profile and glycated hemoglobin (HbA1c). Glucose 83-90 interleukin 27 Homo sapiens 9-14 32292786-2 2020 We recently reported that systemic delivery of IL-27 using recombinant adeno-associated virus (rAAV) induced depletion of Tregs and significantly enhanced the efficacy of cancer immunotherapy in a variety of mouse tumor models. tregs 122-127 interleukin 27 Homo sapiens 47-52 31786500-8 2020 RESULTS: IL-27 was elevated in sepsis patients with acute hepatic injury, which correlated with the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHEII) scores, Sequential Organ Failure Assessment (SOFA) scores, and procalcitonin, C-reactive protein, IL-6, and TNF-alpha expression. pct 236-249 interleukin 27 Homo sapiens 9-14 31155348-8 2020 CONCLUSION: Our results suggested that decreased IL-27 expression in AR were correlated with Th2 response. th2 93-96 interleukin 27 Homo sapiens 49-54 31216373-5 2019 Moreover, we found that TCSle cDCs express higher levels of IL-27 upon TLR7/TLR9 stimulation, and IFNAR blockade reduced IL-27 levels in TCSle cDCs. Chenodeoxycholate 3-sulphate 30-34 interleukin 27 Homo sapiens 60-65 31034891-7 2019 Here, we show that formation of a single disulfide bond is an evolutionary conserved trait, which determines secretion-competency of IL-27alpha. Disulfides 41-50 interleukin 27 Homo sapiens 133-143 30906479-10 2019 Thus, these findings indicate that IL-27 and IL-6 may be trait markers in patients being administered olanzapine monotherapy at the onset of schizophrenia. Olanzapine 102-112 interleukin 27 Homo sapiens 35-40 30936876-4 2019 PGE2 diminished the capacity of GM-CSF/IL-6 M-MDSC to produce proinflammatory cytokines upon activation and augmented their capacity to produce IL-27, IL-33, and TGF-beta. Dinoprostone 0-4 interleukin 27 Homo sapiens 144-149 30421605-0 2018 IL-27 Production and Regulation in Human Dendritic Cells Treated with the Chemical Sensitizer NiSO4. nickel sulfate 94-99 interleukin 27 Homo sapiens 0-5 30421605-5 2018 In this work, we aimed to extend our knowledge on nickel regulation of the IL-12 cytokine family by focusing on IL-27, a recently identified immunomodulatory cytokine from this family. Nickel 50-56 interleukin 27 Homo sapiens 112-117 30421605-6 2018 We showed that nickel induced the production of IL-27 in human monocyte-derived DC (MoDC), regulating IL-22 production by human CD4+ T cells. Nickel 15-21 interleukin 27 Homo sapiens 48-53 30421605-7 2018 We also showed that nickel was able to induce the expression of the two subunits of IL-27: il-27p28 and ebi3. Nickel 20-26 interleukin 27 Homo sapiens 84-89 30421605-7 2018 We also showed that nickel was able to induce the expression of the two subunits of IL-27: il-27p28 and ebi3. Nickel 20-26 interleukin 27 Homo sapiens 91-99 30421605-11 2018 Our results contribute to a better understanding of nickel-induced ACD by focusing on the IL-12 cytokine family and elucidating the mechanism of IL-27 regulation in human dendritic cells. Nickel 52-58 interleukin 27 Homo sapiens 145-150 30039429-0 2018 Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. honokiol 0-8 interleukin 27 Homo sapiens 62-67 30039429-0 2018 Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. magnolol 13-21 interleukin 27 Homo sapiens 62-67 30815354-11 2019 Moreover, IMQ-induced inflammatory cytokines; Th1 cytokines (TNF-alpha, IFN-alpha, IFN-gamma,and IL-27) and Th17 cytokines (IL-17A and IL-23), in the serum and skin showed marked inhibition by hE-MSCs. Imiquimod 10-13 interleukin 27 Homo sapiens 97-102 30242126-7 2018 In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27. Tetradecanoylphorbol Acetate 65-96 interleukin 27 Homo sapiens 288-293 32251441-7 2020 In addition, the plasma levels of IL-27, TGF-beta1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3. Cholecalciferol 130-140 interleukin 27 Homo sapiens 34-39 31988799-8 2020 Excluding genes in the human leukocyte antigen region, significant enrichment is present for pathways like interleukin-27 pathway and NO2-dependent interleukin-12 pathway in natural killer cells. Aligeron 134-137 interleukin 27 Homo sapiens 107-121 31274540-12 2019 A combination of 2D-DIG-electrophoresis and western blot assays demonstrated that IL-27-treatment induces a change in posttranslational modification of Y box binding protein-1 (YB-1). 2d-dig 17-23 interleukin 27 Homo sapiens 82-87 31681561-0 2019 IL-27, IL-30, and IL-35: A Cytokine Triumvirate in Cancer. triumvirate 36-47 interleukin 27 Homo sapiens 0-5 30820808-0 2019 Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells. salvin 0-13 interleukin 27 Homo sapiens 51-56 30820808-3 2019 The aim of this study was to investigate the effect of carnosic acid on CXC chemokine receptor 3 (CXCR3) ligands, which are involved in Th1 cells migration and accumulation, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). salvin 55-68 interleukin 27 Homo sapiens 188-207 30820808-4 2019 Carnosic acid decreased CXC chemokine ligand (CXCL)9, CXCL10, and CXCL11 production in IL-27-stimulated TR146 cells in a dose-dependent fashion. salvin 0-13 interleukin 27 Homo sapiens 87-92 30820808-5 2019 Moreover, we disclosed that carnosic acid could suppress signal transducer and activator of transcription (STAT)1, STAT3, and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells. salvin 28-41 interleukin 27 Homo sapiens 168-173 31009295-0 2019 Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment. Poly I-C 0-9 interleukin 27 Homo sapiens 75-89 31009295-5 2019 Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. Poly I-C 67-98 interleukin 27 Homo sapiens 34-39 31009295-5 2019 Our results demonstrate that when IL-27 or IFN-gamma is added with polyinosinic-polycytidylic acid [poly(I:C)], type I IFN (IFN-I) expression increases concurrently with cell death. Poly I-C 100-109 interleukin 27 Homo sapiens 34-39 30880234-0 2019 Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants. Vitamin E 87-96 interleukin 27 Homo sapiens 18-23 30880234-0 2019 Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants. Polyethylene 133-145 interleukin 27 Homo sapiens 18-23 30039429-3 2018 The aim of this study was to examine the effect of honokiol and magnolol on CXC chemokine receptor 3 (CXCR3) ligands, which are related with Th1 cell migration, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). honokiol 51-59 interleukin 27 Homo sapiens 175-194 30039429-3 2018 The aim of this study was to examine the effect of honokiol and magnolol on CXC chemokine receptor 3 (CXCR3) ligands, which are related with Th1 cell migration, production in interleukin (IL)-27-stimulated human oral epithelial cells (TR146 cells). magnolol 64-72 interleukin 27 Homo sapiens 175-194 30039429-4 2018 Honokiol and magnolol inhibited CXC chemokine ligand (CXCL)10 and CXCL11 production in IL-27-stimulated TR146 cells in a dose-dependent manner. honokiol 0-8 interleukin 27 Homo sapiens 87-92 30039429-4 2018 Honokiol and magnolol inhibited CXC chemokine ligand (CXCL)10 and CXCL11 production in IL-27-stimulated TR146 cells in a dose-dependent manner. magnolol 13-21 interleukin 27 Homo sapiens 87-92 30039429-5 2018 Moreover, we revealed that honokiol and magnolol could suppress signal transducer and activator of transcription (STAT)3 and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells though STAT1 phosphorylation was not suppressed by honokiol and magnolol treatment. honokiol 27-35 interleukin 27 Homo sapiens 167-172 30039429-5 2018 Moreover, we revealed that honokiol and magnolol could suppress signal transducer and activator of transcription (STAT)3 and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells though STAT1 phosphorylation was not suppressed by honokiol and magnolol treatment. magnolol 40-48 interleukin 27 Homo sapiens 167-172 30039429-5 2018 Moreover, we revealed that honokiol and magnolol could suppress signal transducer and activator of transcription (STAT)3 and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells though STAT1 phosphorylation was not suppressed by honokiol and magnolol treatment. honokiol 247-255 interleukin 27 Homo sapiens 167-172 30039429-5 2018 Moreover, we revealed that honokiol and magnolol could suppress signal transducer and activator of transcription (STAT)3 and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells though STAT1 phosphorylation was not suppressed by honokiol and magnolol treatment. magnolol 260-268 interleukin 27 Homo sapiens 167-172 29508072-10 2018 We found that PIR-A/B+ cDCs produced IL-27, as verified by an ELISA assay, and that the inhibitory effect by PIR-A/B+ cDCs was, at least partially, due to IL-27. Chenodeoxycholate 3-sulphate 23-27 interleukin 27 Homo sapiens 37-42 29508072-10 2018 We found that PIR-A/B+ cDCs produced IL-27, as verified by an ELISA assay, and that the inhibitory effect by PIR-A/B+ cDCs was, at least partially, due to IL-27. Chenodeoxycholate 3-sulphate 118-122 interleukin 27 Homo sapiens 155-160 30143585-10 2018 Treatment of wild-type and IRAK1-deficient murine macrophages with fludarabine similarly reduced TLR3/4-induced IL-27 cytokine levels. fludarabine 67-78 interleukin 27 Homo sapiens 112-117 29221667-12 2018 In vitro IL-8 production by IL-27 and IL-37 pre-treated neutrophils and monocytes was significantly inhibited even after heme addition. Heme 121-125 interleukin 27 Homo sapiens 28-33 29221667-15 2018 Therefore, IL-27 and IL-37 may be potential immuno-targets for ameliorating complications associated with elevated heme levels seen in SCA and other hemolytic anemias. Heme 115-119 interleukin 27 Homo sapiens 11-16 29618655-4 2018 Strikingly, we found that AAV-IL-27 treatment causes rapid depletion of Tregs in peripheral blood, lymphoid organs, and - most pronouncedly - tumor microenvironment. tregs 72-77 interleukin 27 Homo sapiens 30-35 29618655-5 2018 AAV-IL-27-mediated Treg depletion is dependent on IL-27 receptor and Stat1 in Tregs and is a combined result of CD25 downregulation in Tregs and inhibition of IL-2 production by T cells. treg 19-23 interleukin 27 Homo sapiens 4-9 29618655-5 2018 AAV-IL-27-mediated Treg depletion is dependent on IL-27 receptor and Stat1 in Tregs and is a combined result of CD25 downregulation in Tregs and inhibition of IL-2 production by T cells. tregs 78-83 interleukin 27 Homo sapiens 4-9 29618655-5 2018 AAV-IL-27-mediated Treg depletion is dependent on IL-27 receptor and Stat1 in Tregs and is a combined result of CD25 downregulation in Tregs and inhibition of IL-2 production by T cells. tregs 135-140 interleukin 27 Homo sapiens 4-9 29618655-7 2018 AAV-IL-27 also dramatically increased the efficacy of anti-PD-1 therapy, presumably due to induction of PD-L1 in T cells and depletion of Tregs. tregs 138-143 interleukin 27 Homo sapiens 4-9 29618655-8 2018 Importantly, AAV-IL-27 therapy did not induce significant adverse events, partially due to its induction of IL-10. CHEMBL2031461 13-16 interleukin 27 Homo sapiens 17-22 29565744-3 2018 Estradiol increased poly (I:C)-induced IL-27 production by fibroblasts, but not epithelial cells. Estradiol 0-9 interleukin 27 Homo sapiens 39-44 28985996-3 2018 TLR-induced secretion of IL-27 was significantly reduced in the NDD group compared to the control (Normal Glucose Tolerance (NGT)) and KDM groups. Nordazepam 64-67 interleukin 27 Homo sapiens 25-30 28985996-3 2018 TLR-induced secretion of IL-27 was significantly reduced in the NDD group compared to the control (Normal Glucose Tolerance (NGT)) and KDM groups. Glucose 106-113 interleukin 27 Homo sapiens 25-30 29565744-3 2018 Estradiol increased poly (I:C)-induced IL-27 production by fibroblasts, but not epithelial cells. poly (i:c) 20-30 interleukin 27 Homo sapiens 39-44 29565744-4 2018 While both cell types expressed the IL-27 receptor, only fibroblasts responded to recombinant IL-27 with increased expression of the antiviral genes, APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) and MxA, and the tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO). Tryptophan 246-256 interleukin 27 Homo sapiens 94-99 29565744-5 2018 Estradiol inhibited IL-27-mediated induction of IDO in fibroblasts through estrogen receptor alpha, but had no effect on APOBEC3G. Estradiol 0-9 interleukin 27 Homo sapiens 20-25 29565744-8 2018 The effect of estradiol on IL-27 production and sensitivity by fibroblasts demonstrates a selective hormone action on individual cell types in the uterus and suggests that IL-27 may have differential effects during the menstrual cycle. Estradiol 14-23 interleukin 27 Homo sapiens 27-32 29167232-7 2018 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. Steroids 38-45 interleukin 27 Homo sapiens 28-33 29140433-5 2018 Results: IL-27 production was elevated during CDI in humans and mice. 1,1'-Carbonyldiimidazole 46-49 interleukin 27 Homo sapiens 9-14 29140433-8 2018 Mechanistically, IL-27-mediated host defense against CDI was associated with downregulation of IL-17A and IL-23, but upregulation of IL-10 and interferon-gamma during CDI. 1,1'-Carbonyldiimidazole 53-56 interleukin 27 Homo sapiens 17-22 29140433-8 2018 Mechanistically, IL-27-mediated host defense against CDI was associated with downregulation of IL-17A and IL-23, but upregulation of IL-10 and interferon-gamma during CDI. 1,1'-Carbonyldiimidazole 167-170 interleukin 27 Homo sapiens 17-22 29167232-7 2018 Production of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflammation. Steroids 135-142 interleukin 27 Homo sapiens 92-97 28746469-0 2017 Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells. Sorafenib 50-59 interleukin 27 Homo sapiens 0-14 29195127-0 2018 Rapamycin Synergizes with Cisplatin in Antiendometrial Cancer Activation by Improving IL-27-Stimulated Cytotoxicity of NK Cells. Sirolimus 0-9 interleukin 27 Homo sapiens 86-91 29195127-0 2018 Rapamycin Synergizes with Cisplatin in Antiendometrial Cancer Activation by Improving IL-27-Stimulated Cytotoxicity of NK Cells. Cisplatin 26-35 interleukin 27 Homo sapiens 86-91 29195127-5 2018 Exposure with rapamycin enhanced the cytotoxicity of NK cells by upregulating the expression of IL-27 in UECC and IL-27 receptors (IL-27Rs: WSX-1 and gp130) on NK cells and further restricted the growth of UEC in Ishikawa-xenografted nude mice. Sirolimus 14-23 interleukin 27 Homo sapiens 114-119 29195127-6 2018 In addition, treatment with rapamycin resulted in an increased autophagy level of UECC, and IL-27 enhanced this ability of rapamycin. Sirolimus 123-132 interleukin 27 Homo sapiens 92-97 29195127-8 2018 These results suggest that rapamycin and cisplatin synergistically activate the cytotoxicity of NK cells and inhibit the progression of UEC in both an IL-27-dependent and -independent manner. Sirolimus 27-36 interleukin 27 Homo sapiens 151-156 29195127-8 2018 These results suggest that rapamycin and cisplatin synergistically activate the cytotoxicity of NK cells and inhibit the progression of UEC in both an IL-27-dependent and -independent manner. Cisplatin 41-50 interleukin 27 Homo sapiens 151-156 29390341-1 2017 BACKGROUND: The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. tpes 230-234 interleukin 27 Homo sapiens 33-47 29390341-1 2017 BACKGROUND: The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. tpes 230-234 interleukin 27 Homo sapiens 49-54 28820066-4 2017 The vital tyrosine residues in WT_IL27 were identified, mutated and IL27 was re-modeled. Tyrosine 10-18 interleukin 27 Homo sapiens 34-38 28820066-4 2017 The vital tyrosine residues in WT_IL27 were identified, mutated and IL27 was re-modeled. Tyrosine 10-18 interleukin 27 Homo sapiens 68-72 28820066-12 2017 Exceptionally several Arg residues from MT_IL27 appeared to play a major role, thereby stabilizing the simulated MT_IL27-gp130 complexes. Arginine 22-25 interleukin 27 Homo sapiens 43-47 28820066-12 2017 Exceptionally several Arg residues from MT_IL27 appeared to play a major role, thereby stabilizing the simulated MT_IL27-gp130 complexes. Arginine 22-25 interleukin 27 Homo sapiens 116-120 28993775-0 2017 IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production. Oxysterols 48-58 interleukin 27 Homo sapiens 0-5 28993775-7 2017 Here, we assessed oxysterol levels in subset of CD4+ T cells and demonstrated that 25-OHC and transcript levels of its synthesizing enzyme, cholesterol 25-hydroxylase, were specifically increased in IL-27-induced type 1 regulatory T (TR1) cells. Oxysterols 18-27 interleukin 27 Homo sapiens 199-204 28993775-9 2017 Not only do these findings unravel molecular mechanisms accounting for IL-27 signaling but also they highlight oxysterols as pro-inflammatory mediators that dampens regulatory T cell responses and thus unleash a pro-inflammatory response. Oxysterols 111-121 interleukin 27 Homo sapiens 71-76 28928459-5 2017 Data from rodent models indicate that interleukin-27 modifies neutrophil maturation in the bone marrow, suppressing their production of pro-inflammatory/cytotoxic products while increasing their production of beneficial iron-scavenging molecules, including lactoferrin. Iron 220-224 interleukin 27 Homo sapiens 38-52 29754565-3 2017 MATERIALS & METHODS: Two SNPs (rs153109 and rs17855750) of IL-27 gene were genotyped by PCR-restriction fragment length polymorphism in 261 DCM patients and 303 unrelated healthy subjects in Chinese Han population. Adenosine Monophosphate 11-14 interleukin 27 Homo sapiens 63-68 28300844-8 2017 Under external (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and local (estrogen, IL-6 and TGF-beta) environmental regulation, IL-27 from macrophages and endometrial stromal cells (ESCs) induces IL-10 production in Th17 cells in vitro and in vivo. Polychlorinated Dibenzodioxins 16-51 interleukin 27 Homo sapiens 125-130 27677834-5 2017 In addition, IL-27 increased TLR3 expression in osteoclasts and enhanced poly(I:C)-mediated induction of IL-27 in these cells. Poly I-C 73-82 interleukin 27 Homo sapiens 13-18 27677834-5 2017 In addition, IL-27 increased TLR3 expression in osteoclasts and enhanced poly(I:C)-mediated induction of IL-27 in these cells. Poly I-C 73-82 interleukin 27 Homo sapiens 105-110 28377398-8 2017 Furthermore, we determined that IL-27 primes cells for enhanced IL-1beta production by up-regulating surface expression of TLR4 and P2X purinoceptor 7 (P2X7) for enhanced LPS and ATP signaling, respectively. Adenosine Triphosphate 179-182 interleukin 27 Homo sapiens 32-37 28377398-9 2017 These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS-ATP stimulation. Adenosine Triphosphate 194-197 interleukin 27 Homo sapiens 41-46 28099429-7 2017 However, Th17 cytokine suppressor IL-27 was significantly increased by hypothermia, negating the IL-27 correlation with vitamin D observed in normothermic HIE infants. Vitamin D 120-129 interleukin 27 Homo sapiens 97-102 28300844-8 2017 Under external (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and local (estrogen, IL-6 and TGF-beta) environmental regulation, IL-27 from macrophages and endometrial stromal cells (ESCs) induces IL-10 production in Th17 cells in vitro and in vivo. Polychlorinated Dibenzodioxins 53-57 interleukin 27 Homo sapiens 125-130 27449853-0 2017 IL-27: a potential biomarker for responders to glatiramer acetate therapy. Glatiramer Acetate 47-65 interleukin 27 Homo sapiens 0-5 27449853-4 2017 Since an increase in IL-27 has been demonstrated to suppress autoimmune and allergic diseases of inflammatory origin, we examined the effect of GA on the production of IL-27. Glatiramer Acetate 144-146 interleukin 27 Homo sapiens 168-173 27449853-6 2017 Interestingly, GA could induce the expression of the IL-27p28 subunit more efficiently than the IL-27 EBI3 subunit, and the production of IL-27 depended on MHC class II binding by GA. Glatiramer Acetate 15-17 interleukin 27 Homo sapiens 53-61 27449853-6 2017 Interestingly, GA could induce the expression of the IL-27p28 subunit more efficiently than the IL-27 EBI3 subunit, and the production of IL-27 depended on MHC class II binding by GA. Glatiramer Acetate 15-17 interleukin 27 Homo sapiens 53-58 27449853-7 2017 In addition, we found that GA could augment Toll-like receptor (TLR)-mediated IL-27 production. Glatiramer Acetate 27-29 interleukin 27 Homo sapiens 78-83 27449853-9 2017 Altogether, our data suggest that GA-induced IL-27 may represent a therapeutic mechanism of GA-mediated immunomodulation and that GA-mediated IL-27 production in PBMCs is worth exploring as a biomarker to screen for GA responders prior to the initiation of GA treatment. Glatiramer Acetate 34-36 interleukin 27 Homo sapiens 45-50 27449853-9 2017 Altogether, our data suggest that GA-induced IL-27 may represent a therapeutic mechanism of GA-mediated immunomodulation and that GA-mediated IL-27 production in PBMCs is worth exploring as a biomarker to screen for GA responders prior to the initiation of GA treatment. Glatiramer Acetate 92-94 interleukin 27 Homo sapiens 45-50 27449853-9 2017 Altogether, our data suggest that GA-induced IL-27 may represent a therapeutic mechanism of GA-mediated immunomodulation and that GA-mediated IL-27 production in PBMCs is worth exploring as a biomarker to screen for GA responders prior to the initiation of GA treatment. Glatiramer Acetate 92-94 interleukin 27 Homo sapiens 45-50 27449853-9 2017 Altogether, our data suggest that GA-induced IL-27 may represent a therapeutic mechanism of GA-mediated immunomodulation and that GA-mediated IL-27 production in PBMCs is worth exploring as a biomarker to screen for GA responders prior to the initiation of GA treatment. Glatiramer Acetate 92-94 interleukin 27 Homo sapiens 45-50 27869736-7 2016 Moreover, immunosuppressive treatment with leflunomide downregulated the levels of IL-27 in active RA patients. Leflunomide 43-54 interleukin 27 Homo sapiens 83-88 28240310-0 2017 Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. Reactive Oxygen Species 41-64 interleukin 27 Homo sapiens 0-14 28240310-2 2017 We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of reactive oxygen species (ROS) generating activity during differentiation of monocytes to macrophages. Reactive Oxygen Species 180-203 interleukin 27 Homo sapiens 37-42 28240310-2 2017 We have previously demonstrated that IL-27 is an anti-viral cytokine which inhibits HIV-1, HIV-2, Influenza virus and herpes simplex virus infection, and enhances the potential of reactive oxygen species (ROS) generating activity during differentiation of monocytes to macrophages. Reactive Oxygen Species 205-208 interleukin 27 Homo sapiens 37-42 28240310-3 2017 In this study, we further investigated the mechanism of the enhanced potential for ROS generation by IL-27. Reactive Oxygen Species 83-86 interleukin 27 Homo sapiens 101-106 28240310-4 2017 Real time PCR, western blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide production not only during differentiation but also in terminally differentiated-macrophages and immature dendritic cells (iDC) in association with the induction of p47phox, a cytosolic component of the ROS producing enzyme, NADPH oxidase, and the increase in amounts of phosphorylated p47phox upon stimulation. Superoxides 109-119 interleukin 27 Homo sapiens 67-72 28240310-4 2017 Real time PCR, western blot and knock down assays demonstrate that IL-27 is able to enhance the potential of superoxide production not only during differentiation but also in terminally differentiated-macrophages and immature dendritic cells (iDC) in association with the induction of p47phox, a cytosolic component of the ROS producing enzyme, NADPH oxidase, and the increase in amounts of phosphorylated p47phox upon stimulation. Reactive Oxygen Species 323-326 interleukin 27 Homo sapiens 67-72 28240310-6 2017 Since ROS plays an important role in a variety of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be a novel therapeutic target. Reactive Oxygen Species 6-9 interleukin 27 Homo sapiens 90-95 28240310-6 2017 Since ROS plays an important role in a variety of inflammation, our data demonstrate that IL-27 is a potent regulator of ROS induction and may be a novel therapeutic target. Reactive Oxygen Species 121-124 interleukin 27 Homo sapiens 90-95 27514076-6 2017 Conversely, an increase in intracellular GSH content stimulates IL-12 and/or IL-27, which in turn induces differentiation of naive CD4+ T cells to Th1 cells. Glutathione 41-44 interleukin 27 Homo sapiens 77-82 26868086-5 2017 In this study, we demonstrated IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine. gemcitabine 214-225 interleukin 27 Homo sapiens 31-36 27748636-9 2016 In contrary, IL-2 and IL-27 were upregulated by Leflunomide and suppressed by HIX. Leflunomide 48-59 interleukin 27 Homo sapiens 22-27 27748636-9 2016 In contrary, IL-2 and IL-27 were upregulated by Leflunomide and suppressed by HIX. hix 78-81 interleukin 27 Homo sapiens 22-27 27119567-7 2016 IL-27 also decreased the responsiveness of the leukemic cells to chemotherapeutic drugs, cytarabine and daunorubicin. Cytarabine 89-99 interleukin 27 Homo sapiens 0-5 27338697-10 2016 MOG inhibited IA, CD40, CD80, CD86 expression and induced TGF-beta, IL-27, IL-10 production in CD11c+ CD11b+ DCs, these effects were abrogated after injection of clodronate-loaded liposomes. Clodronic Acid 162-172 interleukin 27 Homo sapiens 68-73 26943324-5 2016 This proposed model is supported by findings showing that the production and release of high concentrations of IL-27 by bone-marrow-derived macrophages (BMDM) is limited to BMDM exposed to those forms of death that simultaneously released ATP and the DAMPs heat-shock protein 90 (HSP90) and high-mobility group box-1 protein (HMGB1). Adenosine Triphosphate 239-242 interleukin 27 Homo sapiens 111-116 26895538-8 2016 Taken together, the elevated Pb levels result in the lower percentages of NK cells, but also alter the levels of platelets, IL-1beta and IL-27, which might be unconducive to the activity and function of NK cells. Lead 29-31 interleukin 27 Homo sapiens 137-142 27119567-7 2016 IL-27 also decreased the responsiveness of the leukemic cells to chemotherapeutic drugs, cytarabine and daunorubicin. Daunorubicin 104-116 interleukin 27 Homo sapiens 0-5 27119567-9 2016 Growth stimulation by IL-27 was suppressed by the specific MEK inhibitor, U0126, indicating that IL-27-induced cell proliferation is mainly mediated through the activation of the MAPK/ERK signaling pathway. U 0126 74-79 interleukin 27 Homo sapiens 22-27 27119567-9 2016 Growth stimulation by IL-27 was suppressed by the specific MEK inhibitor, U0126, indicating that IL-27-induced cell proliferation is mainly mediated through the activation of the MAPK/ERK signaling pathway. U 0126 74-79 interleukin 27 Homo sapiens 97-102 26735612-4 2016 Furthermore, melatonin enhances splenic interleukin (IL)-10 expression in regulatory T cells by inducing IL-27 expression in the splenic DC; it also suppresses the expression of IFN-gamma, IL-17, IL-6, and CCL20 in the CNS and inhibits antigen-specific T cell proliferation. Melatonin 13-22 interleukin 27 Homo sapiens 105-110 26662568-4 2016 Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60-0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72-0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65-0.94). Thioguanine 116-118 interleukin 27 Homo sapiens 31-36 26662568-4 2016 Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60-0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72-0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65-0.94). Thioguanine 237-239 interleukin 27 Homo sapiens 31-36 25698903-8 2015 The co-stimulation in vitro of PBMC with mite allergens and Ascaris lumbricoides antigens depressed the allergen-induced pro-inflammatory IL-27, IL-33 and MIP3-alpha/CCL20 responses while regulatory IL-10 remained unaffected. PBMC 31-35 interleukin 27 Homo sapiens 138-143 26432006-2 2016 Documentation documents that tyrosine residues in IL27 play a pivotal role for interacting with HIV, causing apoptosis of the HIV+ cells. Tyrosine 29-37 interleukin 27 Homo sapiens 50-54 26432006-5 2016 Two mutant models for IL27 were prepared following the similar protocol by first substituting the tyrosine residues with glycine (MT_G) and then with alanine (MT_A) in the WT protein. Tyrosine 98-106 interleukin 27 Homo sapiens 22-26 26432006-5 2016 Two mutant models for IL27 were prepared following the similar protocol by first substituting the tyrosine residues with glycine (MT_G) and then with alanine (MT_A) in the WT protein. Glycine 121-128 interleukin 27 Homo sapiens 22-26 26432006-5 2016 Two mutant models for IL27 were prepared following the similar protocol by first substituting the tyrosine residues with glycine (MT_G) and then with alanine (MT_A) in the WT protein. Alanine 150-157 interleukin 27 Homo sapiens 22-26 26657115-6 2015 IDO and PD-L1 were not constitutively expressed by EOC cells in vitro, but IL-27 increased their expression through STAT1 and STAT3 tyrosine phosphorylation. Tyrosine 132-140 interleukin 27 Homo sapiens 75-80 26360023-0 2015 Anti-Inflammatory Effects of IL-27 in Zymosan-Induced Peritonitis: Inhibition of Neutrophil Recruitment Partially Explained by Impaired Mobilization from Bone Marrow and Reduced Chemokine Levels. Zymosan 38-45 interleukin 27 Homo sapiens 29-34 26360023-6 2015 Early administration of recombinant IL-27 strongly reduced the number of neutrophils recruited to the peritoneal cavity after zymosan application as well as the neutrophil frequency in the blood. Zymosan 126-133 interleukin 27 Homo sapiens 36-41 24909905-2 2014 Although plasma levels of IL-27 are shown to be associated with cITP, its association with T cell subsets has not been studied. citp 64-68 interleukin 27 Homo sapiens 26-31 26111958-5 2015 RESULTS: Significantly higher plasma levels of IL-12p70, IL-23, IL-27, IFN-gamma and IL-17A were observed in cITP patients than in controls (p < 0.01), and after HD-DXM treatment, these levels decreased significantly (p < 0.01). citp 109-113 interleukin 27 Homo sapiens 64-69 25194807-2 2014 Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux and increasing ABCA1 expression at both protein and mRNA levels. Cholesterol 114-125 interleukin 27 Homo sapiens 23-28 26523208-8 2014 However, IL-27 mediated STAT3 activation was decreased by the addition of apricoxib. apricoxib 74-83 interleukin 27 Homo sapiens 9-14 24909905-3 2014 The objective of this study was to study the association between IL-27 and different T cell subsets in patients with cITP. citp 117-121 interleukin 27 Homo sapiens 65-70 24909905-8 2014 The percentage of Th1 and Th17 cells and the plasma concentration and mRNA levels of IL-27 were significantly higher in cITP patients compared with healthy controls. citp 120-124 interleukin 27 Homo sapiens 85-90 24909905-9 2014 Plasma levels of IL-27 correlated positively with percentage of Th1 cells in patients with cITP. citp 91-95 interleukin 27 Homo sapiens 17-22 24909905-12 2014 The up-regulation of IL-27 might cause Th1 differentiation and might be involved in the pathophysiology of cITP. citp 107-111 interleukin 27 Homo sapiens 21-26 24730521-9 2014 DCs stimulated with rIL-37 showed a decreased expression of IL-6, IL-1beta and TNF-alpha, and a higher production of IL-27. ril-37 20-26 interleukin 27 Homo sapiens 117-122 24682316-9 2014 Nonetheless, lower levels of IL-12 p40 and IL-27 p28 proteins were found in the supernatants of macrophages treated with either GSH-C4 or ACV, likely as an indirect consequence of inhibited HSV-1 replication. glutathione-C4 128-134 interleukin 27 Homo sapiens 43-48 24682316-9 2014 Nonetheless, lower levels of IL-12 p40 and IL-27 p28 proteins were found in the supernatants of macrophages treated with either GSH-C4 or ACV, likely as an indirect consequence of inhibited HSV-1 replication. Acyclovir 138-141 interleukin 27 Homo sapiens 43-48 25236666-5 2014 METHODS: rs153109, corresponding to position c.-964A>G of the IL-27 locus, was amplified from genomic DNA extracted from 15 patients with chronic hepatitis C stratified by sustained viral response (SVR), relapser and non-responder, after treatment with peginterferon-alpha (PegIFN- alpha) combined with ribavirin (RBV). peginterferon-alpha 256-275 interleukin 27 Homo sapiens 65-70 23962500-2 2014 We studied the efficacy of interleukin-27 (IL-27) in the diagnosis of TBPE. tbpe 70-74 interleukin 27 Homo sapiens 27-41 23962500-2 2014 We studied the efficacy of interleukin-27 (IL-27) in the diagnosis of TBPE. tbpe 70-74 interleukin 27 Homo sapiens 43-48 23962500-9 2014 CONCLUSIONS: IL-27 is less efficient than ADA and ADA-2 in the diagnosis of TBPE. tbpe 76-80 interleukin 27 Homo sapiens 13-18 23890319-9 2014 High levels of IL-27 then positively correlated with Tbil levels (r = 0.401, P = 0.004), but negatively associated with prothrombin time activity levels (r = -0.496, P < 0.001), and a slightly negative correlation trend with HBV-DNA loads (r = -0.228, P = 0.107) existed in these HBV-infected subjects. tbil 53-57 interleukin 27 Homo sapiens 15-20 24021664-6 2014 Overexpression of IL-27p28 in vivo ameliorated EAU as well as EAE pathology and reduced tissue infiltration by Th1 and Th17 cells in a disease prevention, as well as in a disease reversal protocol. Water 47-50 interleukin 27 Homo sapiens 18-26 24337382-6 2014 Moreover, IL-27-activated IFN-lambda1 upregulates IFN-lambda1 receptor (IL-28R1 and IL-10Rbeta) activity, resulting in the activation of the STAT1/2 pathway, which, in turn, induces the expression of IFN-stimulated genes, including IFN-inducible dsRNA-activated protein kinase, oligoadenylate synthetase 1, and IFN-induced GTP-binding protein 1 and, finally, inhibits HBV protein expression and viral capsid-associated DNA replication. Guanosine Triphosphate 323-326 interleukin 27 Homo sapiens 10-15 25236666-5 2014 METHODS: rs153109, corresponding to position c.-964A>G of the IL-27 locus, was amplified from genomic DNA extracted from 15 patients with chronic hepatitis C stratified by sustained viral response (SVR), relapser and non-responder, after treatment with peginterferon-alpha (PegIFN- alpha) combined with ribavirin (RBV). pegifn- alpha 277-290 interleukin 27 Homo sapiens 65-70 25236666-5 2014 METHODS: rs153109, corresponding to position c.-964A>G of the IL-27 locus, was amplified from genomic DNA extracted from 15 patients with chronic hepatitis C stratified by sustained viral response (SVR), relapser and non-responder, after treatment with peginterferon-alpha (PegIFN- alpha) combined with ribavirin (RBV). Ribavirin 306-315 interleukin 27 Homo sapiens 65-70 25236666-5 2014 METHODS: rs153109, corresponding to position c.-964A>G of the IL-27 locus, was amplified from genomic DNA extracted from 15 patients with chronic hepatitis C stratified by sustained viral response (SVR), relapser and non-responder, after treatment with peginterferon-alpha (PegIFN- alpha) combined with ribavirin (RBV). Ribavirin 317-320 interleukin 27 Homo sapiens 65-70 23731464-0 2013 The suppressive effect of IL-27 on encephalitogenic Th17 cells induced by multiwalled carbon nanotubes reduces the severity of experimental autoimmune encephalomyelitis. Carbon 86-92 interleukin 27 Homo sapiens 26-31 24034707-0 2013 Rapamycin augments human DC IL-12p70 and IL-27 secretion to promote allogeneic Type 1 polarization modulated by NK cells. Sirolimus 0-9 interleukin 27 Homo sapiens 41-46 23731464-7 2013 These results suggest that the increased IL-27 level produced by the APCs incubated with the carbon nanotubes inhibits the development of Th17 cells. Carbon 93-99 interleukin 27 Homo sapiens 41-46 23333920-8 2013 Our results demonstrated that IL-27 induced and synergized with TNF-alpha to up-regulate CXCL10 mRNA and protein concentrations in a steroid-insensitive manner. Steroids 133-140 interleukin 27 Homo sapiens 30-35 23727477-4 2013 In the present study, we demonstrate that IL-27 inhibits the production of IL-22 and induces the expression of IFN-gamma in CD4(+) T cells from human umbilical cord blood mononuclear cells (CBMCs) stimulated with anti-CD3 and anti-CD28 in dose-dependent manner. cbmcs 190-195 interleukin 27 Homo sapiens 42-47 23583238-7 2013 IL-30 treatment decreased apoptosis in liver tissue and increased glutathione (GSH) levels. Glutathione 66-77 interleukin 27 Homo sapiens 0-5 23583238-7 2013 IL-30 treatment decreased apoptosis in liver tissue and increased glutathione (GSH) levels. Glutathione 79-82 interleukin 27 Homo sapiens 0-5 22951728-4 2013 IMQ-treated skin showed an increase of IL-27 mRNA levels and the infiltration of IL-27-producing cells in the papillary dermis. Imiquimod 0-3 interleukin 27 Homo sapiens 39-44 22925810-0 2013 IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-kappaB and MAPKs. Nitric Oxide 15-27 interleukin 27 Homo sapiens 0-5 22925810-5 2013 In the present study, we investigated the effects of IL-27 on NO production in thioglycollate-elicited peritoneal macrophages. Thioglycolates 79-93 interleukin 27 Homo sapiens 53-58 23390294-0 2013 A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties. Polyglutamic Acid 2-19 interleukin 27 Homo sapiens 34-39 23390294-0 2013 A polyglutamic acid motif confers IL-27 hydroxyapatite and bone-binding properties. Durapatite 40-54 interleukin 27 Homo sapiens 34-39 23390294-4 2013 The IL-27 polyglutamic acid domain is located in a flexible inter-alpha helix loop, and HA-bound IL-27 retained biological activity. Polyglutamic Acid 10-27 interleukin 27 Homo sapiens 4-9 23390294-5 2013 Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo. Alanine 12-19 interleukin 27 Homo sapiens 122-127 23390294-5 2013 Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo. Polyglutamic Acid 54-71 interleukin 27 Homo sapiens 6-11 23390294-5 2013 Using IL-27 alanine mutants, we observed that the p28 polyglutamic acid domain confers HA- and bone-binding properties to IL-27 in vitro and bone tropism in vivo. Polyglutamic Acid 54-71 interleukin 27 Homo sapiens 122-127 22951728-4 2013 IMQ-treated skin showed an increase of IL-27 mRNA levels and the infiltration of IL-27-producing cells in the papillary dermis. Imiquimod 0-3 interleukin 27 Homo sapiens 81-86 22951728-5 2013 The injection of IL-27 to the IMQ-treated skin exacerbated the disease compared with PBS injection. Imiquimod 30-33 interleukin 27 Homo sapiens 17-22 22951728-7 2013 Finally, IL-27 antagonism attenuated the upregulation of IFN-gamma, CXCL9, CXCL10, CXCL11, and TNF-alpha mRNA levels, and induced clinical and histological improvement in the IMQ-treated skin. Imiquimod 175-178 interleukin 27 Homo sapiens 9-14 22951728-8 2013 These results indicate that IL-27 would act in a proinflammatory manner, and thereby exacerbate the psoriasis-like skin inflammation induced by IMQ. Imiquimod 144-147 interleukin 27 Homo sapiens 28-33 22389321-0 2012 Histamine down-regulates IL-27 production in antigen-presenting cells. Histamine 0-9 interleukin 27 Homo sapiens 25-30 22669715-12 2012 Treatment with corticosteroids and cyclosporine A (CsA) resolved the intraocular inflammation in association with an upregulation of IL-27 and a downregulation of IL-17. Cyclosporine 35-49 interleukin 27 Homo sapiens 133-138 22669715-12 2012 Treatment with corticosteroids and cyclosporine A (CsA) resolved the intraocular inflammation in association with an upregulation of IL-27 and a downregulation of IL-17. Cyclosporine 51-54 interleukin 27 Homo sapiens 133-138 23076801-3 2013 We report that simvastatin inhibits IL-1beta, IL-23, TGF-beta, IL-21, IL-12p70, and induces IL-27 secretion from DCs in RRMS patients, providing an inhibitory cytokine milieu for Th17 and Th1-cell differentiation. Simvastatin 15-26 interleukin 27 Homo sapiens 92-97 22389321-2 2012 Since histamine was described to inhibit IL-12 production in human APCs, we hypothesized that also the expression of IL-27, a newly described member of the IL-12 family, which is present in inflammatory skin lesions, is modulated by histamine. Histamine 6-15 interleukin 27 Homo sapiens 117-122 22389321-2 2012 Since histamine was described to inhibit IL-12 production in human APCs, we hypothesized that also the expression of IL-27, a newly described member of the IL-12 family, which is present in inflammatory skin lesions, is modulated by histamine. Histamine 233-242 interleukin 27 Homo sapiens 117-122 22389321-3 2012 Stimulation of human monocytes with histamine resulted in significant reduction of TLR ligand-induced IL-27 production in human monocytes. Histamine 36-45 interleukin 27 Homo sapiens 102-107 22389321-5 2012 Studies with histamine receptor-specific agonists and antagonists showed that the down-regulation of IL-27 was mediated via H(2)R and H(4)R but not H(1)R and H(3)R. Human KCs treated with supernatants of histamine-prestimulated monocytes induced significantly less CXCL10 than supernatants containing high levels of IL-27. Histamine 13-22 interleukin 27 Homo sapiens 101-106 22389321-7 2012 The down-regulation of IL-27 by histamine might be a new mechanism in the pathogenesis of inflammatory skin diseases, in particular, if increased concentrations of histamine are present at sites of inflammation, such as in chronic eczema and psoriasis. Histamine 32-41 interleukin 27 Homo sapiens 23-28 22389321-7 2012 The down-regulation of IL-27 by histamine might be a new mechanism in the pathogenesis of inflammatory skin diseases, in particular, if increased concentrations of histamine are present at sites of inflammation, such as in chronic eczema and psoriasis. Histamine 164-173 interleukin 27 Homo sapiens 23-28 22343630-5 2012 Clinical analysis showed that IL-27 levels were significantly elevated in a cohort of patients infected with IAV compared with healthy individuals and that circulating IL-27 levels were tightly and positively correlated with prostaglandin E(2) levels. Prostaglandins E 225-240 interleukin 27 Homo sapiens 168-173 22678911-7 2012 Immunosuppression via Treg cells was transferable and required the release of sphingosine-1-phosphate (S1P) from apoptotic cells, acting via S1P receptor 4 on DCs to induce IL-27 secretion. sphingosine 1-phosphate 78-101 interleukin 27 Homo sapiens 173-178 22343630-3 2012 Additionally, IAV triggered IL-27 expression through protein kinase A and cAMP-response element-binding protein signaling, which was mediated by cyclooxygenase-2-derived prostaglandin E(2). Cyclic AMP 74-78 interleukin 27 Homo sapiens 28-33 21778255-0 2012 IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10. Terbium 68-70 interleukin 27 Homo sapiens 0-5 22343630-3 2012 Additionally, IAV triggered IL-27 expression through protein kinase A and cAMP-response element-binding protein signaling, which was mediated by cyclooxygenase-2-derived prostaglandin E(2). Prostaglandins E 170-185 interleukin 27 Homo sapiens 28-33 22287114-7 2012 However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-beta-producing CD4+T cells. ni-ti rs 9-17 interleukin 27 Homo sapiens 123-128 21545428-0 2011 Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization. Glutathione 14-25 interleukin 27 Homo sapiens 74-79 21856273-5 2011 However, mature 5-aza-DC secreted significantly lower levels of IL-10 and IL-27 compared to mature control DC (p = 0.04 and p = 0.005, respectively). Azacitidine 16-21 interleukin 27 Homo sapiens 74-79 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. Glutathione 7-10 interleukin 27 Homo sapiens 168-173 21545428-6 2011 Lipopolysaccharide-induced interleukin (IL)-27 production was enhanced by GSH-OEt and suppressed by BSO, but neither GSH-OEt nor BSO affected the expression of HLA-DR, CD80, CD83, or CD86. Glutathione 74-77 interleukin 27 Homo sapiens 27-46 21420486-5 2011 IFN-beta induced IL-27 expression by DC, and neutralisation of IL-27 abrogated the suppressive effects of IFN-beta on zymosan-induced IL-1 and IL-23 production and the generation of Th17 cells in vitro. Zymosan 118-125 interleukin 27 Homo sapiens 17-22 21545428-7 2011 Mature GSH-OEt-treated MD-DCs enhanced interferon (IFN)-gamma production from CD4(+) T cells compared with nontreated MD-DCs, and small interfering RNA (siRNA) against IL-27 suppressed the effect of GSH-OEt on IFN-gamma production. S-ethyl glutathione 7-14 interleukin 27 Homo sapiens 168-173 21545428-9 2011 Interleukin-27 siRNA attenuated the inhibitory effect of GSH-OEt on Th2 polarization. S-ethyl glutathione 57-64 interleukin 27 Homo sapiens 0-14 21545428-10 2011 CONCLUSION: Our results reveal that Th1 and Th2 responses are controlled by intracellular glutathione redox status in DCs through IL-27 production. Glutathione 90-101 interleukin 27 Homo sapiens 130-135 21420486-5 2011 IFN-beta induced IL-27 expression by DC, and neutralisation of IL-27 abrogated the suppressive effects of IFN-beta on zymosan-induced IL-1 and IL-23 production and the generation of Th17 cells in vitro. Zymosan 118-125 interleukin 27 Homo sapiens 63-68 20817120-5 2010 We showed that loxoribine up-regulated the expression of TLR7, CD40, CD54, CD80, CD83 and CCR7 and stimulated the production of IL-12, IL-23, IL-27 and IL-10 by MoDCs, whereas the level of interferon (IFN)-beta was not modulated. loxoribine 15-25 interleukin 27 Homo sapiens 142-147 21044121-0 2010 Stimulatory effect of LPS and feedback effect of PGE2 on IL-27 production. Dinoprostone 49-53 interleukin 27 Homo sapiens 57-62 21044121-6 2010 We have also shown that IL-27 induced PGE2 production and COX-2 gene expression at the level of mRNA as well as protein. Dinoprostone 38-42 interleukin 27 Homo sapiens 24-29 21044121-7 2010 Moreover, we found feed back effect of PGE2 on the production of IL-27 in THP-1 cells. Dinoprostone 39-43 interleukin 27 Homo sapiens 65-70 21044121-8 2010 The results suggest that PGE2 significantly inhibits LPS-induced IL-27 production, without affecting basal IL-27 expression. Dinoprostone 25-29 interleukin 27 Homo sapiens 65-70 21044121-9 2010 Further experiment suggests that PGE2 and LPS regulate IL-27 through NF-kappaB pathway. Dinoprostone 33-37 interleukin 27 Homo sapiens 55-60 21550664-4 2011 First, inhibition of cPKCs activity in human DCs by a cPKC-specific inhibitor, Go6976 downregulated the expression of IL-12p70 and IL-27p28 but not IL-12/IL-23p40, IL-23, IL-27EBI3 induced by LPS or poly(I:C). Go 6976 79-85 interleukin 27 Homo sapiens 131-139 20705635-6 2011 IL-27 levels also correlated positively with serum levels of hyaluronan, recently identified as an endogenous ligand for Toll-like receptors. Hyaluronic Acid 61-71 interleukin 27 Homo sapiens 0-5 20705635-8 2011 IL-27 production by cultured monocytes was increased by hyaluronan stimulation. Hyaluronic Acid 56-66 interleukin 27 Homo sapiens 0-5 20883313-6 2010 IL-27 also suppressed lipopolysaccharide-induced ROS production and attenuated cytotoxic granule components production in the cytoplasm of human neutrophils. Reactive Oxygen Species 49-52 interleukin 27 Homo sapiens 0-5 20870174-1 2010 The molecular mechanisms underlying retinoic acid (RA) augmentation of T cell receptor (TCR) and transforming growth factor-beta (TGF-beta)-induced Foxp3 transcription and inhibition of the latter by cytokines such as IL-27 were here shown to be related processes involving modifications of baseline (TGF-beta-induced) phosphorylated Smad3 (pSmad3) binding to a conserved enhancer region (enhancer I). Tretinoin 36-49 interleukin 27 Homo sapiens 218-223 20870174-1 2010 The molecular mechanisms underlying retinoic acid (RA) augmentation of T cell receptor (TCR) and transforming growth factor-beta (TGF-beta)-induced Foxp3 transcription and inhibition of the latter by cytokines such as IL-27 were here shown to be related processes involving modifications of baseline (TGF-beta-induced) phosphorylated Smad3 (pSmad3) binding to a conserved enhancer region (enhancer I). Tretinoin 51-53 interleukin 27 Homo sapiens 218-223 19924133-6 2010 Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1alpha and CCL20. Tyrosine 91-99 interleukin 27 Homo sapiens 13-18 20416175-8 2010 After incubation with specific inhibitors, SB203580, not LY294002 and U0126, inhibited the down-regulation of Mac-1 expression by IL-27. SB 203580 43-51 interleukin 27 Homo sapiens 130-135 19915058-6 2009 Surprisingly, DC.Tbets were impaired in their production of IL-12 family member cytokines (IL-12p70, IL-23, and IL-27) when compared with control DC, and the capacity of DC.Tbet to preferentially prime type 1 T cell responses was only minimally inhibited by cytokine (IL-12p70, IL-23, IFN-gamma) neutralization or receptor (IL-12Rbeta2, IL-27R) blockade during T cell priming. tbets 17-22 interleukin 27 Homo sapiens 112-117 20416175-10 2010 Interestingly, LY294002, not SB203580 and U0126, inhibited the up-regulation of fMLP-R and IL-1beta by IL-27. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 interleukin 27 Homo sapiens 103-108 20034529-8 2010 In this setting, poly(I:C) further augments IL-6, IL-12p35, IL-23p19, and IL-27p28 transcription, whereas lipopolysaccharide (LPS) increases IL-23p19 and IL-27p28 transcription. Poly I-C 17-26 interleukin 27 Homo sapiens 74-82 19915058-6 2009 Surprisingly, DC.Tbets were impaired in their production of IL-12 family member cytokines (IL-12p70, IL-23, and IL-27) when compared with control DC, and the capacity of DC.Tbet to preferentially prime type 1 T cell responses was only minimally inhibited by cytokine (IL-12p70, IL-23, IFN-gamma) neutralization or receptor (IL-12Rbeta2, IL-27R) blockade during T cell priming. tbet 17-21 interleukin 27 Homo sapiens 112-117 18453621-4 2008 Simvastatin also induced IFN-gamma, IL-4, and IL-27 production in monocytes, which together inhibited IL-17 transcription and secretion in CD4(+) T cells. Simvastatin 0-11 interleukin 27 Homo sapiens 46-51 17502394-5 2007 CFP-activated PBMC from BBCG- and DBCG-immunized children expressed high levels of cytokines characteristic of an adaptive immune response (gamma interferon, interleukin-2beta [IL-12beta], and IL-27), while those from children immunized with JBCG did not. dbcg 34-38 interleukin 27 Homo sapiens 193-198 17727629-4 2007 The cytokines interferon-gamma and tumor necrosis factor-alpha also stimulated IL-12 p40 and IL-27 p28 expression by microglia, which was suppressed by fenofibrate. Fenofibrate 152-163 interleukin 27 Homo sapiens 93-98 17727629-6 2007 In addition, fenofibrate suppressed the secretion of IL-12p40, IL-23, and IL-27p28 by lipopolysaccharide-stimulated astrocytes. Fenofibrate 13-24 interleukin 27 Homo sapiens 74-82 17922695-4 2007 RESULTS: Female sex steroid hormones enhance the life cycle of mDCs, thus increasing the maturation and apoptosis, they also increase the production of interleukin (IL)-10 and IL-27 but only Pg increases the production of IL-13 and down regulates the secretion of IL-23. Steroids 20-36 interleukin 27 Homo sapiens 176-181 18389480-5 2008 The stimulatory effects of IL-12, IL-23, and IL-27 were suppressed by antisense oligonucleotides against NF-kappaB p50 and p65. Oligonucleotides 80-96 interleukin 27 Homo sapiens 45-50 18389480-9 2008 IL-12 and IL-23 tyrosine phosphorylated STAT3 and STAT1, respectively; IL-12, IL-23, and IL-27 tyrosine phosphorylated JAK2 and tyrosine kinase-2; and IL-27 tyrosine phosphorylated JAK1. Tyrosine 95-103 interleukin 27 Homo sapiens 89-94 18389480-9 2008 IL-12 and IL-23 tyrosine phosphorylated STAT3 and STAT1, respectively; IL-12, IL-23, and IL-27 tyrosine phosphorylated JAK2 and tyrosine kinase-2; and IL-27 tyrosine phosphorylated JAK1. Tyrosine 95-103 interleukin 27 Homo sapiens 89-94 17727629-3 2007 The present studies demonstrated that the PPAR-alpha agonist fenofibrate inhibited the secretion of IL-12p40, IL-12p70 (p35/p40), IL-23 (p19/p40), and IL-27p28 by lipopolysaccharide-stimulated microglia. Fenofibrate 61-72 interleukin 27 Homo sapiens 151-159 16329649-8 2006 Very recently, IL-27 was found to exert not only a pro-inflammatory Thl-enhancing but also a significant anti-inflammatory function. Orlistat 68-71 interleukin 27 Homo sapiens 15-20 17237441-4 2007 The present studies demonstrated that PPAR-gamma agonists, including the naturally occurring 15-deoxy-Delta(12,14)-PGJ(2) and the synthetic thiazoladinedione rosiglitazone, inhibited the induction of IL-12p40, IL-12p70 (p35/p40), IL-23 (p19/p40), and IL-27p28 proteins by LPS-stimulated primary microglia. 15-deoxy-delta(12,14)-pgj 93-118 interleukin 27 Homo sapiens 251-259 17237441-4 2007 The present studies demonstrated that PPAR-gamma agonists, including the naturally occurring 15-deoxy-Delta(12,14)-PGJ(2) and the synthetic thiazoladinedione rosiglitazone, inhibited the induction of IL-12p40, IL-12p70 (p35/p40), IL-23 (p19/p40), and IL-27p28 proteins by LPS-stimulated primary microglia. thiazoladinedione rosiglitazone 140-171 interleukin 27 Homo sapiens 251-259 17237441-7 2007 The 15-deoxy-Delta(12,14)-PGJ(2) potently suppressed IL-12p40, IL-23, and IL-27p28 production by primary astrocytes, whereas rosiglitazone suppressed IL-23 and IL-27p28, but not IL-12p40 in these cells. Rosiglitazone 125-138 interleukin 27 Homo sapiens 160-168 17114427-5 2006 Similarly, the p38 MAPK inhibitor, SB203580, or the inhibitor of ERK1/2 phosphorylation, PD98059, partially suppressed IL-27-induced Th1 differentiation and the combined treatment completely suppressed it. SB 203580 35-43 interleukin 27 Homo sapiens 119-124 17114427-5 2006 Similarly, the p38 MAPK inhibitor, SB203580, or the inhibitor of ERK1/2 phosphorylation, PD98059, partially suppressed IL-27-induced Th1 differentiation and the combined treatment completely suppressed it. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 89-96 interleukin 27 Homo sapiens 119-124 17548652-5 2007 We assessed the effects of PGE(2) on IL-12, IL-27, and IL-23 and found that PGE(2) promotes IL-23, inhibits IL-12 and IL-27 expression and release from stimulated DCs, and subsequently induces IL-17 production in activated T cells. Prostaglandins E 76-79 interleukin 27 Homo sapiens 44-49 17548652-5 2007 We assessed the effects of PGE(2) on IL-12, IL-27, and IL-23 and found that PGE(2) promotes IL-23, inhibits IL-12 and IL-27 expression and release from stimulated DCs, and subsequently induces IL-17 production in activated T cells. Prostaglandins E 76-79 interleukin 27 Homo sapiens 118-123 16641133-5 2006 IL-27, which could mimic the effect of IL-12, was however less potent in inducing IFN-gamma production in the presence of CsA and TCR stimulation. Cyclosporine 122-125 interleukin 27 Homo sapiens 0-5 15585838-5 2004 The majority of mice cured of their original TBJ-IL-27 tumors were resistant to tumor rechallenge. 1-cyclopentyl-3-[[(2~{S})-oxolan-2-yl]methyl]urea 45-48 interleukin 27 Homo sapiens 49-54 15486065-7 2005 We found that ATP also inhibited IL-27 expression but enhanced IL-23 expression. Adenosine Triphosphate 14-17 interleukin 27 Homo sapiens 33-38 15486065-8 2005 Interestingly, the reciprocal regulation of IL-12/IL-27 and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also induced by prostaglandin E(2) by cyclic adenosine monophosphate (cAMP)-elevating EP2/EP4 receptors. Adenosine Triphosphate 69-72 interleukin 27 Homo sapiens 50-55 15486065-8 2005 Interestingly, the reciprocal regulation of IL-12/IL-27 and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also induced by prostaglandin E(2) by cyclic adenosine monophosphate (cAMP)-elevating EP2/EP4 receptors. Prostaglandins E 137-152 interleukin 27 Homo sapiens 50-55 15486065-8 2005 Interestingly, the reciprocal regulation of IL-12/IL-27 and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also induced by prostaglandin E(2) by cyclic adenosine monophosphate (cAMP)-elevating EP2/EP4 receptors. Cyclic AMP 159-189 interleukin 27 Homo sapiens 50-55 15486065-8 2005 Interestingly, the reciprocal regulation of IL-12/IL-27 and IL-23 by ATP was mediated by 2 distinct P2 receptors and was also induced by prostaglandin E(2) by cyclic adenosine monophosphate (cAMP)-elevating EP2/EP4 receptors. Cyclic AMP 191-195 interleukin 27 Homo sapiens 50-55